CN107158045A - Clever water dust ball and preparation method thereof - Google Patents
Clever water dust ball and preparation method thereof Download PDFInfo
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- CN107158045A CN107158045A CN201710428787.5A CN201710428787A CN107158045A CN 107158045 A CN107158045 A CN 107158045A CN 201710428787 A CN201710428787 A CN 201710428787A CN 107158045 A CN107158045 A CN 107158045A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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Abstract
The invention discloses a kind of clever water dust ball and preparation method thereof, it is characterized in that ganoderma lucidum, rainbow conk are extracted using carbon dioxide supercritical extraction method, jet is spray dried to nano powder, addition polymerization ethylene glycol, instill in atoleine, spirit water dust ball is made, for treating hepatitis, it is evident in efficacy to be better than classical liver treating medicine, achieve good result.
Description
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of clever water dust ball and preparation method thereof.
Background technology
Ganoderma lucidum is the drying fructification of On Polyporaceae red sesame or purple sesame, with invigorating qi for tranquilization, the effect of relieving cough and asthma,
For having no peace of mind, palpitaition of having a sleepless night, deficiency syndrome of the lung cough and asthma, consumptive disease is losed heart, do not feel like eating.Rainbow conk is On Polyporaceae multi-color cord stilbene lid bacterium
Drying fructification.With invigorating spleen to remove dampness, the effect of clearing heat and detoxicating, for jaundice with damp-heat pathogen, hypochondriac pain, lassitude hypodynamia.Ganoderma lucidum and cloud
Sesame possesses very high medical value as Chinese tradition valuable ingredient of traditional Chinese medicine, can strengthen body immunity, adjusts blood glucose, controls blood pressure,
Liver protecting.There are a large amount of activated proteins and biological polypeptide in ganoderma lucidum and rainbow conk, effective ingredient is inactivated in tradition is extracted, it is impossible to filled
Its effect is waved in distribution, and conventional dosage forms, which are made, to be fully dissolved out active ingredient, and prolonged disintegration, bioavilability is low, shadow
Ring curative effect.With ganoderma lucidum and rainbow conk prescription, using modern dripping pill technology, clever water dust ball is made in I, for the treatment of hepatitis, obtains
Good result.
The content of the invention
The present invention provides a kind of effective ingredient and is not destroyed, and extracts the high clever water dust ball of complete, bioavilability and its system
Preparation Method.
Invention embodiment is as follows：
90~110 parts of ganoderma lucidum is taken, 40~60 parts of rainbow conk is ground into 40 mesh coarse powder, extracted using carbon dioxide supercritical extraction method,
20~30Mpa of extracting pressure, 25~35 DEG C of extraction temperature, 12~18Mpa of separator pressure, 35~45 DEG C of separator temperature, two
Carbon flow 20~30L, disengaging time 1 hour per hour are aoxidized, extract solution is obtained；Take extract solution to put in jet spray dryer, control
25~35 DEG C of EAT processed, the Mpa of pressure 0.02~0.04,400~600 meters per second of flow velocity obtains a nanometer extract powder；Take extraction
Powder adds 1~2 times of amount Macrogol 6000s mixings, and 60~70 DEG C of control material temperature, 2~6 DEG C of condensation temperature is dripped away from 2.0~4.0
㎝, drop speed 20~30 drop per minute, instills in atoleine, is taken out after dripping pill shaping, sucks surface coolant, and 60 DEG C of decompressions are dry
It is dry to produce clever water dust ball.
The raw material standards that the embodiment above is previously mentioned is as follows：
Ganoderma lucidum：The Chinese Pharmacopoeia ministerial standard of version one in 2015；
Rainbow conk：The Chinese Pharmacopoeia ministerial standard of version one in 2015；
Macrogol 6000：The Chinese Pharmacopoeia ministerial standard of version two in 2015；
Atoleine：The Chinese Pharmacopoeia ministerial standard of version two in 2015；
Raw material used in above spirit water dust ball can be commercially available from pharmaceuticals, can be used to as long as meeting national standard
Implement the present invention program.
Unspecified Parameter Conditions and term are all with Chinese Pharmacopoeia and state food drug surveilance pipe in embodiments above
The guideline that reason office promulgates is defined.
" part " in embodiments above refers to parts by weight.
Embodiment
The specific embodiment 1 of the present invention
Ganoderma lucidum 90g, rainbow conk 40g are taken, 40 mesh coarse powder is ground into, is extracted using carbon dioxide supercritical extraction method, extracting pressure
20Mpa, 25 DEG C of extraction temperature, separator pressure 12Mpa, 35 DEG C of separator temperature, carbon dioxide flow 20L per hour, separation
1 hour time, obtain extract solution；Take extract solution to put in jet spray dryer, control 25 DEG C of EAT, pressure 0.02Mpa, stream
400 meters per second of speed, obtains a nanometer extract powder；Extract powder plus 1 times of amount Macrogol 6000 is taken to mix, control material temperature 60 C is cold
Solidifying 2 DEG C of temperature, drop is away from 2.0 ㎝, and drop speed 20 drop per minute instills in atoleine, taken out after dripping pill shaping, sucks surface cooling
Liquid, 60 DEG C are dried under reduced pressure and produce clever water dust ball.
The specific embodiment 2 of the present invention
Ganoderma lucidum 110g, rainbow conk 60g are taken, 40 mesh coarse powder is ground into, is extracted using carbon dioxide supercritical extraction method, extracting pressure
30Mpa, 35 DEG C of extraction temperature, separator pressure 18Mpa, 45 DEG C of separator temperature, carbon dioxide flow 30L per hour, separation
1 hour time, obtain extract solution；Take extract solution to put in jet spray dryer, control 35 DEG C of EAT, pressure 0.04Mpa, stream
600 meters per second of speed, obtains a nanometer extract powder；Extract powder plus 2 times of amount Macrogol 6000s are taken to mix, control material temperature 70 C is cold
Solidifying 6 DEG C of temperature, drop is away from 4.0 ㎝, and drop speed 30 drop per minute instills in atoleine, taken out after dripping pill shaping, sucks surface cooling
Liquid, 60 DEG C are dried under reduced pressure and produce clever water dust ball.
The specific embodiment 3 of the present invention
Ganoderma lucidum 100g, rainbow conk 50g are taken, 40 mesh coarse powder is ground into, is extracted using carbon dioxide supercritical extraction method, extracting pressure
25Mpa, 30 DEG C of extraction temperature, separator pressure 15Mpa, 40 DEG C of separator temperature, carbon dioxide flow 25L per hour, separation
1 hour time, obtain extract solution；Take extract solution to put in jet spray dryer, control 30 DEG C of EAT, pressure 0.03Mpa, stream
500 meters per second of speed, obtains a nanometer extract powder；Extract powder plus 2 times of amount Macrogol 6000s are taken to mix, 65 DEG C of control material temperature is cold
Solidifying 3 DEG C of temperature, drop is away from 3.0 ㎝, and drop speed 25 drop per minute instills in atoleine, taken out after dripping pill shaping, sucks surface cooling
Liquid, 60 DEG C are dried under reduced pressure and produce clever water dust ball.
Above example illustrates, clever water dust can be made using the extreme condition and optimal conditions of embodiment of the present invention
Ball.The actual effect of the present invention is investigated with clever water dust ball made from embodiment 3 below：
The clever water dust ball of test example one is contrasted with commercially available dripping pills of ganoderma lucidum effective component content
1 assay method
Clever water dust ball and/or dripping pills of ganoderma lucidum 2g, finely ground, mixing are taken, 0.2g is taken, it is accurately weighed, plus ethanol 20ml, it is heated to reflux 1 small
When, filtration, recycling design is to doing, and residue adds methanol to make dissolving and be transferred in 100ml measuring bottles, plus methanol is to scale, shakes up, filter
Cross, take subsequent filtrate as need testing solution.It is another to take DEXTROSE ANHYDROUS reference substance appropriate, it is accurately weighed, plus methanol is made every 1ml and contains
0.1mg solution, as reference substance solution.Using octadecylsilane chemically bonded silica as filler, with methanol-water（45：55）For
Mobile phase, Detection wavelength is 325nm, and number of theoretical plate is calculated by DEXTROSE ANHYDROUS peak should be not less than 3000.Accurate absorption pair respectively
According to product solution and each 10ul of need testing solution, liquid chromatograph is injected, is determined, calculating DEXTROSE ANHYDROUS with peak area external standard method contains
Amount.
2 DEXTROSE ANHYDROUS content balances
The clever water dust ball of table 1 and dripping pills of ganoderma lucidum DEXTROSE ANHYDROUS content balance table
The above results show that clever water dust ball prepared by the present invention is relative to the active constituents extraction of dripping pills of ganoderma lucidum completely, effectively
The remarkable advantages such as component content height.
Test example two leaches time limit contrast
The clever water dust ball of table 2 and dripping pills of ganoderma lucidum leach time limit contrast table
The above results show, clever water dust ball prepared by the present invention leaches the time limit relative to dripping pills of ganoderma lucidum significantly to be shortened, biological utilisation
Degree significantly increases.
The clever water dust ball treatment hepatitis clinical observation on the therapeutic effect of test example three
1 case scenario
Outpatient service and inpatient are counted, hepatitis 174, average age 54 years old are observed altogether.Patient has different degrees of liver
Area's pain, jaundice, nausea, transaminase such as increase at the symptom, and hepatitis is diagnosed as by TCM syndrome diagnostic criteria.
2 treatment methods
Patient is randomly divided into two groups, test group takes clever water dust ball, and control group takes liver-benefiting dropping pill.
3 efficacy assessment standards
According to new Chinese medicine treatment of insomnia patients guideline of clinical investigations tcm syndrome curative effect determinate standard：
Cure：Tcm clinical practice symptom, sign disappear or basic disappearance, and syndrome integral reduces >=95%；
It is effective：Tcm clinical practice symptom, sign are obviously improved, and syndrome integral reduces >=70%；
Effectively：Tcm clinical practice symptom, sign take a favorable turn, and syndrome integral reduces >=30%；
It is invalid：Tcm clinical practice symptom, sign are not improved or aggravated, and syndrome integral reduces ＜ 30%.
Calculation formula：[（Integrated before treatment after integration-treatment）Integrated before ÷ treatments] × 100%.
4 clinical observation results
The clever water dust ball of table 3 and liver-benefiting dropping pill clinical efficacy contrast table
Above-mentioned clinical observation on the therapeutic effect result shows, evident in efficacy higher than classics during clever water dust ball treatment hepatitis prepared by the present invention
Medicine liver-benefiting dropping pill, p ＜ 0.01.
Claims (3)
1. the Chinese medicine dripping pills of hepatopathy are treated a kind of, it is characterized in that taking 90~110 parts of ganoderma lucidum, 40~60 parts of rainbow conk is ground into 40 mesh
Coarse powder, is extracted using carbon dioxide supercritical extraction method, 20~30Mpa of extracting pressure, 25~35 DEG C of extraction temperature, separator pressure
12~18Mpa of power, 35~45 DEG C of separator temperature, carbon dioxide flow 20~30L, disengaging time 1 hour per hour must be extracted
Liquid；Take extract solution to put in jet spray dryer, control 25~35 DEG C of EAT, the Mpa of pressure 0.02~0.04, flow velocity is every
400~600 meters of second, obtain a nanometer extract powder；Extract powder is taken plus 1~2 times of amount Macrogol 6000s mixings, control material temperature 60~
70 DEG C, 2~6 DEG C of condensation temperature, drop is away from 2.0~4.0 ㎝, and drop speed 20~30 drop per minute is instilled in atoleine, dripping pill shaping
After take out, suck surface coolant, 60 DEG C are dried under reduced pressure and produce clever water dust ball.
2. the preparation method of Chinese medicine dripping pills according to claim 1, it is characterized in that taking 90~110 parts of ganoderma lucidum, rainbow conk 40~60
Part, 40 mesh coarse powder are ground into, are extracted using carbon dioxide supercritical extraction method, 20~30Mpa of extracting pressure, extraction temperature 25~
35 DEG C, 12~18Mpa of separator pressure, 35~45 DEG C of separator temperature, carbon dioxide flow 20~30L per hour, during separation
Between 1 hour, obtain extract solution；Extract solution is taken to put in jet spray dryer, 25~35 DEG C of EAT of control, pressure 0.02~
0.04 Mpa, 400~600 meters per second of flow velocity, obtains a nanometer extract powder；Extract powder is taken plus 1~2 times of amount Macrogol 6000s mixings,
60~70 DEG C of control material temperature, 2~6 DEG C of condensation temperature, drop is away from 2.0~4.0 ㎝, and drop speed 20~30 drop per minute instills liquid
In body paraffin, taken out after dripping pill shaping, suck surface coolant, 60 DEG C are dried under reduced pressure and produce clever water dust ball.
3. the preparation method of Chinese medicine dripping pills according to claim 1, it is characterized in that taking 100 parts of ganoderma lucidum, 50 parts of rainbow conk is ground into
40 mesh coarse powder, are extracted using carbon dioxide supercritical extraction method, extracting pressure 25Mpa, 30 DEG C of extraction temperature, separator pressure
15Mpa, 40 DEG C of separator temperature, carbon dioxide flow 25L, disengaging time 1 hour per hour obtain extract solution；Extract solution is taken to put
In jet spray dryer, 30 DEG C of EAT is controlled, pressure 0.03Mpa, 500 meters per second of flow velocity obtains a nanometer extract powder；Take and carry
Powder plus 2 times of amount Macrogol 6000s are taken to mix, 65 DEG C of control material temperature, 3 DEG C of condensation temperature, drop is away from 3.0 ㎝, and drop speed is per minute
25 drops, are instilled in atoleine, are taken out after dripping pill shaping, are sucked surface coolant, and 60 DEG C are dried under reduced pressure and produce clever water dust ball.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710428787.5A CN107158045A (en) | 2017-06-08 | 2017-06-08 | Clever water dust ball and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710428787.5A CN107158045A (en) | 2017-06-08 | 2017-06-08 | Clever water dust ball and preparation method thereof |
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| CN107158045A true CN107158045A (en) | 2017-09-15 |
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| CN201710428787.5A Pending CN107158045A (en) | 2017-06-08 | 2017-06-08 | Clever water dust ball and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109200085A (en) * | 2018-11-30 | 2019-01-15 | 徐世华 | A kind of Chinese medicine and preparation method thereof for treating hepatopathy |
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| CN1583087A (en) * | 2004-05-22 | 2005-02-23 | 刘贤英 | Chinese health-care medicine for reducing blood sugar and preventing from diabete complication and its preparation |
| CN1634121A (en) * | 2004-10-15 | 2005-07-06 | 北京正大绿洲医药科技有限公司 | Dripping pills of ganoderma lucidum polysaccharide and polystictus versicolor polysaccharide |
| CN1730005A (en) * | 2005-08-03 | 2006-02-08 | 包头中药有限责任公司 | Method for preparing dripping pills of ganoderma lucidum |
| CN102614242A (en) * | 2012-04-13 | 2012-08-01 | 孙长海 | Dropping pill of isatis root and folium isatidis and preparing method thereof |
| CN104855778A (en) * | 2015-05-29 | 2015-08-26 | 傅春华 | Kidney reinforcing and yin replenishing polysaccharide and preparation technology thereof |
-
2017
- 2017-06-08 CN CN201710428787.5A patent/CN107158045A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1583087A (en) * | 2004-05-22 | 2005-02-23 | 刘贤英 | Chinese health-care medicine for reducing blood sugar and preventing from diabete complication and its preparation |
| CN1634121A (en) * | 2004-10-15 | 2005-07-06 | 北京正大绿洲医药科技有限公司 | Dripping pills of ganoderma lucidum polysaccharide and polystictus versicolor polysaccharide |
| CN1730005A (en) * | 2005-08-03 | 2006-02-08 | 包头中药有限责任公司 | Method for preparing dripping pills of ganoderma lucidum |
| CN102614242A (en) * | 2012-04-13 | 2012-08-01 | 孙长海 | Dropping pill of isatis root and folium isatidis and preparing method thereof |
| CN104855778A (en) * | 2015-05-29 | 2015-08-26 | 傅春华 | Kidney reinforcing and yin replenishing polysaccharide and preparation technology thereof |
Non-Patent Citations (1)
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| 张晓萍等: "真菌多糖对小白鼠实验性肝炎的某些药理作用", 《东北师大学报(自然科学版)》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109200085A (en) * | 2018-11-30 | 2019-01-15 | 徐世华 | A kind of Chinese medicine and preparation method thereof for treating hepatopathy |
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Application publication date: 20170915 |