CN107137653A - The Guiding herbs guide liquid and preparation method of a kind of adjuvant treatment of bronchial asthma - Google Patents

The Guiding herbs guide liquid and preparation method of a kind of adjuvant treatment of bronchial asthma Download PDF

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CN107137653A
CN107137653A CN201710346636.5A CN201710346636A CN107137653A CN 107137653 A CN107137653 A CN 107137653A CN 201710346636 A CN201710346636 A CN 201710346636A CN 107137653 A CN107137653 A CN 107137653A
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parts
chinese medicine
guide liquid
bronchial asthma
adjuvant treatment
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王霞
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Abstract

The invention belongs to traditional Chinese medical science field, it is related to the Guiding herbs guide liquid and preparation method of a kind of adjuvant treatment of bronchial asthma, is prepared from by wilsonii, Calamus, the bighead atractylodes rhizome, Shi Shi, small diuranthera root, dried orange peel, evodia rutaecarpa, inular flower, Chinese ephedra, agalloch eaglewood, Fa Luohai, cornel coptis, melanoidin malt, fructus amomi.Present invention is particularly suitable in paracmasis insufficiency of the spleen Bronchial Asthmas, using the transdermal administration of iontophoresis combination Guiding herbs guide liquid, directly act on part, medicine can be made to keep higher concentration and retain the long period, and play drug therapy effect to tissue release medicine ion in an uninterrupted manner, to consolidate the therapeutic effect of acupuncture and moxibustion therapy bronchial astehma, reach not only take stopgap measures but also effect a permanent cure, the purpose that prognosis is stable.

Description

The Guiding herbs guide liquid and preparation method of a kind of adjuvant treatment of bronchial asthma
Technical field
The invention belongs to traditional Chinese medical science field, it is related to the Guiding herbs guide liquid and preparation method of a kind of adjuvant treatment of bronchial asthma, Specifically related to a kind of auxiliary treatment is in the Guiding herbs guide liquid and preparation method of the paracmasis insufficiency of the spleen bronchial astehma.
Background technology
Bronchial astehma abbreviation asthma, is common ictal, pulmonary hypersensitivity disease.Breaking-out typically has seasonality.Greatly Cause different degrees of bronchial spasm, mucous membrane water by allergen or other factors on the basis of bronchial reactivity increases more Swollen, mucous secretion increases and the change such as mucomembranous cilium dysfunction.
This sick cause of disease mainly has following factor：(1) intolerance factors (extrinsic asthma)：There is the trouble of allergic constitution Person can cause morbidity when sucking anaphylaxis antigens particulate or infecting.Sensibiligen be mainly suction pollen, room dirt, mite, Animal dander, industrial dust, fungal spore；Enter ichthyophagy, crab, shrimp, or contact industrial dye etc., can also cause allergy.Immunology Research show suction allergy antigen, the specificity antibody IgE (immunoglobulin E) of volume can be produced, bronchus is attached to On the mast cell and blood basophil of mucous membrane.If patient contacts same antigen again, antigen is i.e. with being attached to hypertrophy carefully The IgE of cellular surface is combined, and is occurred allergic reaction, is discharged various bioactivators (such as histamine, serotonin, long response time Element, bradykinin etc.), make tunica mucosa bronchiorum hyperemia, oedema, smooth muscle spasm increases with glandular secretion, bronchiole luminal stenosis, Pulmonary ventilation is smooth and difficulty of feeling sleepy, and causes asthma attack.(2) infective agent (intrinsic asthma)：It is especially sick by virus or bacterium Toxicity respiratory tract infection, gradually forms and excites asthma extremely common.Sensibiligen is the metabolism production of bacterium or virus ex vivo Thing, therefore not removed in time with nose, pharynx, tonsillotome, lung or other infection focus has substantial connection.But at present excited by infecting or The mechanism for forming asthma is not still fully aware of.This disease is former except contact allergy, outside the risk factor such as respiratory tract infection, per often and weather Cataclysm is cold and mental element is relevant.Property and action pathway through refreshing factor are complicated, it may be possible to which cerebral cortex is acted on In thalamus, make thalamus function change and cause it is vagal be overexcited, secrete acetylcholine so that add bronchus put down The tension force of sliding flesh.(3) inherent cause：Asthmatic patient often has familial and heredity.
At present, although the conventional steroid medicine of western medical treatment asthma and bronchodilator can improve SOA. But the generation of presence and the adverse reaction due to drug resistance, often declines this sick confidence of patient for treatment.In China, acupuncture is controlled Treatment asthma is with a long history, and method uniqueness is various, because its curative effect is affirmed and is had no adverse reaction and clinically extensive use.Study table Bright, acupuncture can improve the ventilatory function of lung, increase pulmonary ventilation volume, improve microcirculation, reduce the airway hyperreactivity of asthmatic patient. In addition, acupuncture can also reduce the quantity of eosinophil in peripheral blood, its aggregation in air flue is reduced, body is improved and exempts from Epidemic disease function, so as to reach therapeutic purposes.But, simple use acupuncture and moxibustion therapy exists and cured the symptoms, not the disease, rear unstable, after The problems such as phase curative effect is not lasting, accordingly, it would be desirable to which adding auxiliary treatment means over the course for the treatment of carrys out after treatment effect, reaches both Take stopgap measures and effect a permanent cure, the purpose that prognosis is stable.
The content of the invention
For defect present in prior art, it is an object of the invention to provide a kind of adjuvant treatment of bronchial asthma Guiding herbs guide liquid and preparation method, are particularly suitable for use in paracmasis insufficiency of the spleen Bronchial Asthmas, using iontophoresis With reference to the transdermal administration of Guiding herbs guide liquid, part is directly acted on, medicine can be made to keep higher concentration and retain the long period, And drug therapy effect is played to tissue release medicine ion in an uninterrupted manner, to consolidate acupuncture and moxibustion therapy bronchial astehma Therapeutic effect, reach not only take stopgap measures but also effect a permanent cure, the purpose that prognosis is stable.
Cutaneous penetration has turned into mankind's third generation administering mode after oral medicine, injection, is beginning of this century administration system One of three general orientation of system development.Because the rate limiting barrier of keratoderma is acted on, the percutaneous abilities of most drug are very poor, thoroughly After skin administration, infiltration rate and infiltration capacity do not reach treatment and required, so finding suitable side when studying transdermal drug delivery system Method improves the permeability of skin, improves the amount of drugs through skin.Improving the method for drug transdermal rate at present has a variety of, mainly It is classified as two kinds of chemical enhancement method and physical aproach to enhancing penetration.Iontophoresis is used as a kind of effective physics side in physical aproach to enhancing penetration Method, is to make medicine ion under 0.1mA or so current density, mainly enters skin by the hole of sweat gland and hair follicle.People Skin be made up of lipoid, protein and water.In the case of Ion electrical import, voltage can change these skin components Molecules align so that certain change occurs for the permeability of skin.Keratin in keratoderma is αhelix Polypeptide, polypeptide generation upset forms arranged in parallel under the electric field, and result mutually exclusive between adjacent dipole is allowed to form people For duct, in order to neutralize dipole moment, hydrone and ion will flow in duct, and this phenomenon will cause peptides and protein Molecular permeability increase.Because keratoderma is under continuous current effect, polarization confrontation electric field is also easy to produce, therefore electro-ionic osmosis is more Using pulse direct current, so when being powered, charged ion enters skin, and electric charge is removed from skin during power-off, that is, is depolarized.
Summarized through applicant, when bronchial astehma is in the paracmasis, have three kinds of different partings, the respectively deficiency syndrome of the lung, kidney It is empty and insufficiency of the spleen.Wherein, the disease of Patients of Spleen Deficiency is：Dyspnea and cough with excessive sputum and it is sticky, cough up and tell not well, gurgling weith sputum, chest distress, nausea is received It is slow-witted, loose stool, white and slippery fur or greasy, slippery.Syndrome analysis：Insufficiency of the spleen strong fortune is had no right, and the turbid interior life of phlegm is stayed and lied prostrate in lung, air flue quilt Resistance, lung qi is lost in a surname's drop, therefore dyspnea and cough with excessive sputum and uncomfortable in chest, gurgling weith sputum；Phlegm coming from spleen, phlegm it is turbid in be stopped at taste, lose in and drop, stomach Gas superinverse event nausea is indigestion and loss of appetite.Tongue is greasy in vain, slippery be phlegm it is turbid in accumulate levy.Therefore, applicant proposes for the treatment of Patients of Spleen Deficiency Following technical scheme：
The Guiding herbs guide liquid of a kind of adjuvant treatment of bronchial asthma, it is characterised in that in parts by weight, in following Medicine raw material is prepared from：15~20 parts of wilsonii, 15~20 parts of Calamus, 15~20 parts of the bighead atractylodes rhizome, teacher real 10~15 parts, small diuranthera root 10 ~15 parts, 15~20 parts of dried orange peel, 10~15 parts of evodia rutaecarpa, 5~10 parts of inular flower, 5~10 parts of Chinese ephedra, 15~20 parts of agalloch eaglewood, method 10~15 parts of sieve sea, 5~10 parts of cornel coptis, 10~15 parts of melanoidin malt, 10~15 parts of fructus amomi.
Wherein, preferred scheme is as follows：
In parts by weight, it can be prepared from by following Chinese medicine material：15 parts of wilsonii, 15 parts of Calamus, the bighead atractylodes rhizome 15 Part, real 10 parts teacher, 10 parts of small diuranthera root, 15 parts of dried orange peel, 10 parts of evodia rutaecarpa, 5 parts of inular flower, 5 parts of Chinese ephedra, 15 parts of agalloch eaglewood, Fa Luohai 10 parts, 5 parts of cornel coptis, 10 parts of melanoidin malt, 10 parts of fructus amomi.
In parts by weight, it can also be prepared from by following Chinese medicine material：20 parts of wilsonii, 20 parts of Calamus, the bighead atractylodes rhizome 20 parts, real 15 parts of teacher, 15 parts of small diuranthera root, 20 parts of dried orange peel, 15 parts of evodia rutaecarpa, 10 parts of inular flower, 10 parts of Chinese ephedra, 20 parts of agalloch eaglewood, method 15 parts of sieve sea, 10 parts of cornel coptis, 15 parts of melanoidin malt, 15 parts of fructus amomi.
In parts by weight, it can also be prepared from by following Chinese medicine material：18 parts of wilsonii, 18 parts of Calamus, the bighead atractylodes rhizome 18 parts, real 12 parts of teacher, 12 parts of small diuranthera root, 18 parts of dried orange peel, 12 parts of evodia rutaecarpa, 8 parts of inular flower, 8 parts of Chinese ephedra, 18 parts of agalloch eaglewood, method sieve 12 parts of sea, 8 parts of cornel coptis, 12 parts of melanoidin malt, 12 parts of fructus amomi.
The preparation method of the Guiding herbs guide liquid of adjuvant treatment of bronchial asthma of the present invention, it is characterised in that according to Lower step is carried out：
(1) weigh Chinese medicine material by above-mentioned parts by weight, prior to 4~10 DEG C under the conditions of refrigerate 12~24h, then at -10~- 10~20h is freezed at 18 DEG C standby；
(2) temperature in microwave storehouse is set as 110~130 DEG C, microwave storehouse is preheated, and then puts into step (1) freezing Chinese medicine material after processing, regulation microwave power is 450~600w, and 120~180s of operation carries out microwave bulking；Then by temperature 40~80 DEG C are adjusted to, microwave power is 90~120w, dries 6~9min；
(3) Chinese medicine material after step (2) processing is put into ball mill and crushed；
(4) Chinese medicine material after crushing is weighed in proportion adds the protease of Chinese medicine material quality 1~2%, 5~8 times of amounts Water is digested, and pH is 4~5 during enzymolysis, and temperature is 45~55 DEG C, 2~4h of time, and alcohol reflux extracts 1~3h after enzymolysis；
(5) extract solution of step (4) is subjected to ultrafiltration, the molecular weight of milipore filter retention is 15000~20000；
(6) liquid after ultrafiltration is sealed after microwave disinfection.
Wherein, preferred scheme is as follows：
Stage drying is used after step (2) microwave bulking, i.e., regulation temperature is 70~80 DEG C first, power 110~ 120w, dries 2~3min；Then regulation temperature is 50~70 DEG C, and 100~110w of power dries 2~3min；Finally adjust temperature Spend for 40~50 DEG C, 90~100w of power dries 2~3min.
The pulverization conditions of the step (3) are just to grind to shut down 3min after 15Min using ball mill, then are stopped after anti-mill 15min Machine 3min, repeatedly so 2 times.
During protease in the step (4) is alkali protease, neutral proteinase, papain or trypsase It is one or more of.
Step (6) the microwave disinfection condition is 70 DEG C~105 DEG C, 90~180 seconds time.
In use, after acupuncture and moxibustion therapy terminates, from ion electro-therapeutic apparatus, by medicine pad (8*12cm 8 layers of sterile gauze system Into) be immersed in after Guiding herbs guide liquid, it is connected on stereotype, and medicine pad is placed at acupuncture point, connect output lead anode.Phase selection is same After the immersion of gauze warm water, it is wrapped on another stereotype, is placed in offside, connects output lead negative electrode.It is solid with bandage outside two stereotypes It is fixed firm.Switch on power, regulation current strength to 10~15mA, sensory threshold is suitable, be degree to patient's tolerance.Start after 10 minutes Pulse current 10 minutes, treatment time is 20 minutes.
Pharmacology analysis：
Wilsonii：Pungent, slight bitter, temperature.Returns spleen, kidney, the heart channel of Hang-Shaoyin.Replenish qi to invigorate the spleen, tonify the kidney to relieve mental strain.It is physically weak weary for the insufficiency of both the spleen and the kindey Power, poor appetite, soreness of waist and knee joint, insomnia and dreamful sleep.
Calamus：Toil, temperature.Resolving sputum, has one's ideas straightened out, invigorating the spleen, dampness removing.Epilepsy is controlled, is palpitated with fear forgetful, mind is not asked, and humidity hysteresis swollen ruffian is let out Rush down dysentery disease, rheumatalgia pain, carbuncle swells scabies.
The bighead atractylodes rhizome：It is bitter, sweet, temperature.Returns spleen, stomach.Strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis is antiabortive.For spleen eating less, abdominal distension Diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, fetal irritability.
Shi Shi：It is sweet；It is mild-natured.Spleen；Stomach.Strengthening the spleen and replenishing qi, stopping nausea and vomiting by lowering the adverse flow of QI.Master is weakness of the spleen and the stomach, vomits hiccup.
Small diuranthera root：It is light, put down.It is clearing heat and detoxicating, it is good for swollen dampness removing.Control rheumatism, infantile malnutrition, mastitis, venomous snake bite.
Dried orange peel：It is bitter, pungent, temperature.Return lung, the spleen channel.Regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm.For chest gastral cavity turgor, deficiency of food is vomited and diarrhoea, cough Abundant expectoration.
Evodia rutaecarpa：It is pungent, temperature.Enter liver, spleen, stomach, large intestine, kidney channel.Middle benefit gas, analgesic, qi-regulating, eliminating dampness is controlled inverse acid regurgitation of vomitting, fainted The moon headache, the cold syndrome in infant is vomited and diarrhoea, abdominal distention, dysmenorrhea, Diarrhoea, vascular hypertension, tinea pedis, hernia, aphthous ulcer, dentalgia, Eczema, impetigo.
Inular flower：It is salty, temperature.Enter lung, liver, stomach.Dissolving phlegm, lower gas, softening hard masses, water-filling.Phlegm knot in the heart is controlled, the lower turgor of the side of body is coughed Breathe heavily, hiccup, saliva such as shellac varnish, epigastric fullness Ying, eructation unrelieved, extensive abdominal edema.
Chinese ephedra：Pungent, slight bitter, temperature.Return lung, bladder warp.Sweating cold dispelling, freeings lung and relieving asthma, inducing diuresis for removing edema.For anemofrigid cold, It is uncomfortable in chest to breath with cough, geomantic omen edema；Bronchial astehma.Herba ephedrae moistens the lung and relieve the cough.It is used for table disease to have solved, asthma and cough.
Agalloch eaglewood：Pungent, hardship, tepor.Returns spleen, stomach, kidney channel.Promoting qi circulation and relieving pain, warming middle energizer to arrest vomiting, gas of receiving is relievingd asthma.It is swollen vexed for chest and abdomen Pain, gastrofrigid vomiting hiccup, the kidney deficiency circulation of vital energy in the wrong direction breathes heavily urgency.
Fa Luohai：It is pungent, bitter, warm-natured.Returns spleen, liver, lung channel.Regulating qi-flowing for relieving pain, it is relieving cough and asthma.Main chest side of body epigastric pain, head Bitterly, cough and asthma.
Cornel coptis：Hardship, trembles with fear.The thoughts of returning home, spleen, stomach, liver, courage, large intestine channel.Easypro liver anti-vomiting.For liver-stomach disharmony, vomiting is gulped down Acid.
Melanoidin malt：It is sweet, put down.Returns spleen, stomach.Promoting the circulation of qi helps digestion, spleen benefiting and stimulating the appetite, moves back newborn dissipate-swelling.For dyspepsia, gastral cavity abdomen is swollen Bitterly, spleen eating less, milk smoulders, swollen breasts, women weans.
Fructus amomi：It is pungent, temperature.Returns spleen, stomach, kidney channel.Dampness elimination appetizing, warming spleen and stopping diarrha, regulating the flow of vital energy antiabortive.For turbi damp obstructing in middle-JIAO, gastral cavity ruffian It is not hungry, deficiency-cold in spleen and stomach, vomiting and diarrhea, pernicious vomiting, fetal irritability.
Wilsonii, Calamus, the bighead atractylodes rhizome, Shi Shi, small diuranthera root invigorating the spleen in Chinese medicine preparation of the present invention, reasonable recipe, prescription QI invigorating；Dried orange peel, evodia rutaecarpa, inular flower regulating qi-flowing for eliminating phlegm；Chinese ephedra, agalloch eaglewood, the inverse Dingchuan of Fa Luohai drops；Cornel coptis, melanoidin malt, fructus amomi and Stomach helps digestion.14 taste Chinese medicines are shared, effective bronchial astehma insufficiency of the spleen for the treatment paracmasis.
Repelled each other according to same sex electric charge in direct-current electrical field, the attracting principle of the charges of different polarity is electrically charged under electric field action Drug microparticles are moved with regard to the electrical direction of anisotropyization, and percutaneous electro-ionic osmosis is exactly to utilize DC electric field effect and electric charge same sex phase Reprimand, the characteristic that there is a natural attraction between the sexes, make medicine ion particulate enter human body, when direct current acts on body, negative ions in tissue Displacement is produced in the presence of electric field, tissue excitability, membrane structure and permeability change, and pass through acupuncture point Chinese medicine Chinese medicine, meridian point and electro-ionic osmosis can be merged by electro-ionic osmosis, the effect of existing acupoint stimulation, further through specific way Footpath makes Chinese medicine in the stimulation influx and translocation of privileged site, plays more obvious pharmacological action.
Outcome measure：
Selection 60 is in the paracmasis insufficiency of the spleen Bronchial Asthmas, is randomly divided into treatment group and each 30 of control group. Wherein, in treatment group, male 16, women 14, average age 41 years old；In control group, male 17, women 13 is average 39 years old age.
Diagnostic criteria：
1st, recurrent exerbation pant, it is out of breath, uncomfortable in chest or cough, more with contact allergen, cold air, physics, chemical irritation, Viral infection of upper respiratory tract, motion etc. are relevant.
In double lung audibles and it is dispersed in or diffusivity, the wheezing sound based on expiratory phase when the 2, breaking out, expiratory phase extension.
3rd, above-mentioned symptom can be alleviated or spontaneous remission through treatment.
4th, atypical symptom person (as nothing is substantially panted or sign) should at least possess and test positive with the next item down.(1) branch gas Pipe provocative test or exercise test are positive；(2) positive [forced expiratory volume (FEV1) increase in one second of Bronchodilation Test More than 15%, and FEV1 increase absolute values>200m1]；(3) maximum expiratory flow volume (PEF) aberration rate or day and night fluctuation rate in day >= 20%.
5th, panting caused by Other diseases, out of breath, uncomfortable in chest and cough except.
Wherein, the patient in catabasis of bronchitis asthma.The division of severity extent：
1st, it is slight：(1) forgo after allergen or other excitation conditions, panting to alleviate；(2) it can be relaxed by general bronchus Agent is opened to be controlled；(3) daily activity can be carried out.
2nd, moderate：(1) exclude after allergen or other excitation conditions, asthma part is alleviated；(2) general bronchodilators It is only capable of retrieval section alleviation；Sometimes need with corticosteroid medication to improve symptom；(3) ADL is restricted.
Treatment method：
Treatment group and control group use Yin Yang balancing pin combination electrical acupuncture method, specific as follows：
(1) acupoint selection：Two groups of acupuncture points are taken, are respectively：(1) Dingchuan, hole most, shen shu；(2) fei shu, big vertebra, Zusanli.Daily 1 group of acupoint selection, is used alternatingly.10~15 days as one therapeutic course.
Treatment group combines the transdermal administration of Guiding herbs guide liquid of the present invention after each acupuncture terminates, then using iontophoresis Treatment, be specially：
After acupuncture terminates, from DZI2g type multi-channel DC electric pulse electro-therapeutic apparatus, by medicine pad (8*12cm 8 layers of sterile yarn Cloth is made) it is immersed in after Guiding herbs guide liquid, it is connected on stereotype, and medicine pad is placed at acupuncture point, connect output lead anode.Choosing After identical gauze warm water immersion, it is wrapped on another stereotype, is placed in offside, connect output lead negative electrode.With taut outside two stereotypes With fixed.Switch on power, regulation current strength to 10~15mA, sensory threshold is suitable, be degree to patient's tolerance.After 10 minutes Starting impulse electric current 10 minutes, treatment time is 20 minutes.
Criterion of therapeutical effect：
Clinical cure：Any medicine is not required to, the asymptomatic person more than 1 year is kept.
It is effective：Idol bronchodilatation medicine and alleviate the person of panting.
Effectively：Wheezing symptoms have mitigated, but need drug therapy person often.
It is invalid：Symptom remains unchanged.
As a result：
Group n Recovery from illness It is effective Effectively It is invalid Total effective rate
Treatment group 30 16 10 3 1 96.7%
Control group 30 10 8 7 5 83.3%
It is statistically analyzed, difference has significant (p>0.05), treatment group's curative effect is better than control group.
Embodiment
The present invention will be further described by the following examples.
Embodiment 1：
A kind of Guiding herbs guide liquid of adjuvant treatment of bronchial asthma, is prepared from accordance with the following methods：
(1) in parts by weight, 15 parts of wilsonii, 15 parts of Calamus, 15 parts of the bighead atractylodes rhizome, teacher real 10 parts, small diuranthera root 10 are weighed Part, 15 parts of dried orange peel, 10 parts of evodia rutaecarpa, 5 parts of inular flower, 5 parts of Chinese ephedra, 15 parts of agalloch eaglewood, 10 parts of method sieve sea, 5 parts of cornel coptis, melanoidin malt 10 parts, 10 parts of fructus amomi, prior to 4 DEG C under the conditions of refrigerate 12h, at -10 DEG C freeze 20h it is standby；
(2) temperature in microwave storehouse is set as 110 DEG C, microwave storehouse is preheated, and is then put into after step (1) freezing processing Chinese medicine material, regulation microwave power be 450w, operation 120s carry out microwave bulking；Stage drying is used after microwave bulking, i.e., Regulation temperature is 70 DEG C first, and power 110w dries 2min；Then regulation temperature is 50 DEG C, and power 100w dries 2min；Most Regulation temperature is 40 DEG C afterwards, and power 90w dries 3min；
(3) Chinese medicine material after step (2) processing is just being ground using ball mill and 3min is shut down after 15Min, then anti-mill 15min After shut down 3min, so repeatedly 2 times；
(4) Chinese medicine material after crushing is weighed in proportion adds the alkali protease of Chinese medicine material quality 1%, 5~8 times of amounts Water is digested, and pH is 4 during enzymolysis, and temperature is 45 DEG C, time 2h, and alcohol reflux extracts 1h after enzymolysis；
(5) extract solution of step (4) is subjected to ultrafiltration, the molecular weight of milipore filter retention is 15000；
(6) liquid after ultrafiltration is sealed after microwave disinfection, microwave disinfection condition is 70 DEG C, 180 seconds time.
Embodiment 2：
A kind of Guiding herbs guide liquid of adjuvant treatment of bronchial asthma, is prepared from accordance with the following methods：
(1) in parts by weight, 20 parts of wilsonii, 20 parts of Calamus, 20 parts of the bighead atractylodes rhizome, teacher real 15 parts, small diuranthera root 15 are weighed Part, 20 parts of dried orange peel, 15 parts of evodia rutaecarpa, 10 parts of inular flower, 10 parts of Chinese ephedra, 20 parts of agalloch eaglewood, 15 parts of method sieve sea, 10 parts of cornel coptis, Jiao 15 parts of malt, 15 parts of fructus amomi, prior to 10 DEG C under the conditions of refrigerate 24h, at -18 DEG C freeze 10h it is standby；
(2) temperature in microwave storehouse is set as 130 DEG C, microwave storehouse is preheated, and is then put into after step (1) freezing processing Chinese medicine material, regulation microwave power be 600w, operation 180s carry out microwave bulking；Stage drying is used after microwave bulking, i.e., Regulation temperature is 80 DEG C first, and power 120w dries 2min；Then regulation temperature is 70 DEG C, and power 110w dries 2min；Most Regulation temperature is 50 DEG C afterwards, and power 100w dries 2min；
(3) Chinese medicine material after step (2) processing is just being ground using ball mill and 3min is shut down after 15Min, then anti-mill 15min After shut down 3min, so repeatedly 2 times；
(4) Chinese medicine material after crushing is weighed in proportion adds the papain of Chinese medicine material quality 2%, the water of 8 times of amounts Digested, pH is 5 during enzymolysis, temperature is 55 DEG C, time 4h, alcohol reflux extracts 3h after enzymolysis；
(5) extract solution of step (4) is subjected to ultrafiltration, the molecular weight of milipore filter retention is 20000；
(6) liquid after ultrafiltration is sealed after microwave disinfection, microwave disinfection condition is 105 DEG C, 90 seconds time.
Embodiment 3：
A kind of Guiding herbs guide liquid of adjuvant treatment of bronchial asthma, is prepared from accordance with the following methods：
(1) in parts by weight, 18 parts of wilsonii, 18 parts of Calamus, 18 parts of the bighead atractylodes rhizome, teacher real 12 parts, small diuranthera root 12 are weighed Part, 18 parts of dried orange peel, 12 parts of evodia rutaecarpa, 8 parts of inular flower, 8 parts of Chinese ephedra, 18 parts of agalloch eaglewood, 12 parts of method sieve sea, 8 parts of cornel coptis, melanoidin malt 12 parts, 12 parts of fructus amomi, prior to 7 DEG C under the conditions of refrigerate 18h, at -15 DEG C freeze 15h it is standby；
(2) temperature in microwave storehouse is set as 120 DEG C, microwave storehouse is preheated, and is then put into after step (1) freezing processing Chinese medicine material, regulation microwave power be 500w, operation 150s carry out microwave bulking；Stage drying is used after microwave bulking, i.e., Regulation temperature is 75 DEG C first, and power 115w dries 2min；Then regulation temperature is 60 DEG C, and power 105w dries 2min；Most Regulation temperature is 45 DEG C afterwards, and power 95w dries 3min；
(3) Chinese medicine material after step (2) processing is just being ground using ball mill and 3min is shut down after 15Min, then anti-mill 15min After shut down 3min, so repeatedly 2 times；
(4) trypsase of Chinese medicine material addition Chinese medicine material quality 2%, the water of 6 times of amounts after crushing are weighed in proportion to enter Row enzymolysis, pH is 4.5 during enzymolysis, and temperature is 50 DEG C, time 3h, and alcohol reflux extracts 2h after enzymolysis；
(5) extract solution of step (4) is subjected to ultrafiltration, the molecular weight of milipore filter retention is 17500；
(6) liquid after ultrafiltration is sealed after microwave disinfection, microwave disinfection condition is 90 DEG C, 150 seconds time.

Claims (9)

1. the Guiding herbs guide liquid of a kind of adjuvant treatment of bronchial asthma, it is characterised in that in parts by weight, by following Chinese medicine Raw material is prepared from：15~20 parts of wilsonii, 15~20 parts of Calamus, 15~20 parts of the bighead atractylodes rhizome, 10~15 parts of teacher's reality, small diuranthera root 10~ 15 parts, 15~20 parts of dried orange peel, 10~15 parts of evodia rutaecarpa, 5~10 parts of inular flower, 5~10 parts of Chinese ephedra, 15~20 parts of agalloch eaglewood, method sieve 10~15 parts of sea, 5~10 parts of cornel coptis, 10~15 parts of melanoidin malt, 10~15 parts of fructus amomi.
2. the Guiding herbs guide liquid of a kind of adjuvant treatment of bronchial asthma according to claim 1, it is characterised in that according to weight Number meter is measured, is prepared from by following Chinese medicine material：15 parts of wilsonii, 15 parts of Calamus, 15 parts of the bighead atractylodes rhizome, teacher real 10 parts, small diuranthera root 10 parts, 15 parts of dried orange peel, 10 parts of evodia rutaecarpa, 5 parts of inular flower, 5 parts of Chinese ephedra, 15 parts of agalloch eaglewood, method sieve sea 10 parts, 5 parts of cornel coptis, Jiao Mai 10 parts of bud, 10 parts of fructus amomi.
3. the Guiding herbs guide liquid of a kind of adjuvant treatment of bronchial asthma according to claim 1, it is characterised in that according to weight Number meter is measured, is prepared from by following Chinese medicine material：20 parts of wilsonii, 20 parts of Calamus, 20 parts of the bighead atractylodes rhizome, teacher real 15 parts, small diuranthera root 15 parts, 20 parts of dried orange peel, 15 parts of evodia rutaecarpa, 10 parts of inular flower, 10 parts of Chinese ephedra, 20 parts of agalloch eaglewood, method sieve sea 15 parts, 10 parts of cornel coptis, 15 parts of melanoidin malt, 15 parts of fructus amomi.
4. the Guiding herbs guide liquid of a kind of adjuvant treatment of bronchial asthma according to claim 1, it is characterised in that according to weight Number meter is measured, is prepared from by following Chinese medicine material：18 parts of wilsonii, 18 parts of Calamus, 18 parts of the bighead atractylodes rhizome, teacher real 12 parts, small diuranthera root 12 parts, 18 parts of dried orange peel, 12 parts of evodia rutaecarpa, 8 parts of inular flower, 8 parts of Chinese ephedra, 18 parts of agalloch eaglewood, method sieve sea 12 parts, 8 parts of cornel coptis, Jiao Mai 12 parts of bud, 12 parts of fructus amomi.
5. a kind of preparation method of the Guiding herbs guide liquid of the adjuvant treatment of bronchial asthma described in claim 1, it is characterised in that Follow the steps below：
(1) weigh Chinese medicine material by above-mentioned parts by weight, prior to 4~10 DEG C under the conditions of refrigerate 12~24h, then at -10~-18 DEG C 10~20h of lower freezing is standby；
(2) temperature in microwave storehouse is set as 110~130 DEG C, microwave storehouse is preheated, and then puts into step (1) freezing processing Chinese medicine material afterwards, regulation microwave power is 450~600w, and 120~180s of operation carries out microwave bulking；Then by temperature adjustment For 40~80 DEG C, microwave power is 90~120w, dries 6~9min；
(3) Chinese medicine material after step (2) processing is put into ball mill and crushed；
(4) protease of Chinese medicine material addition Chinese medicine material quality 1~2%, the water of 5~8 times of amounts after crushing are weighed in proportion to enter Row enzymolysis, pH is 4~5 during enzymolysis, and temperature is 45~55 DEG C, 2~4h of time, and alcohol reflux extracts 1~3h after enzymolysis；
(5) extract solution of step (4) is subjected to ultrafiltration, the molecular weight of milipore filter retention is 15000~20000；
(6) liquid after ultrafiltration is sealed after microwave disinfection.
6. a kind of preparation method of the Guiding herbs guide liquid of adjuvant treatment of bronchial asthma according to claim 5, its feature It is：Stage drying is used after step (2) microwave bulking, i.e., regulation temperature is 70~80 DEG C first, power 110~ 120w, dries 2~3min；Then regulation temperature is 50~70 DEG C, and 100~110w of power dries 2~3min；Finally adjust temperature Spend for 40~50 DEG C, 90~100w of power dries 2~3min.
7. a kind of preparation method of the Guiding herbs guide liquid of adjuvant treatment of bronchial asthma according to claim 5, its feature It is：The pulverization conditions of the step (3) are just to grind to shut down 3min after 15Min using ball mill, then are shut down after anti-mill 15min 3min, repeatedly so 2 times.
8. a kind of preparation method of the Guiding herbs guide liquid of adjuvant treatment of bronchial asthma according to claim 5, its feature It is：Protease in the step (4) is one in alkali protease, neutral proteinase, papain or trypsase Plant or several.
9. a kind of preparation method of the Guiding herbs guide liquid of adjuvant treatment of bronchial asthma according to claim 5, its feature It is：Step (6) the microwave disinfection condition is 70 DEG C~105 DEG C, 90~180 seconds time.
CN201710346636.5A 2017-05-17 2017-05-17 The Guiding herbs guide liquid and preparation method of a kind of adjuvant treatment of bronchial asthma Pending CN107137653A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101129667A (en) * 2007-08-25 2008-02-27 尹克华 Traditional Chinese medicine for treating bronchial asthma
CN104173641A (en) * 2014-07-16 2014-12-03 周剑峰 Traditional Chinese medicine preparation for treating bronchial asthma

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101129667A (en) * 2007-08-25 2008-02-27 尹克华 Traditional Chinese medicine for treating bronchial asthma
CN104173641A (en) * 2014-07-16 2014-12-03 周剑峰 Traditional Chinese medicine preparation for treating bronchial asthma

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* Cited by examiner, † Cited by third party
Title
何韦霆 等: "支气管哮喘的中医药研究进展", 《黑龙江中医药》 *

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