CN107053521A - A kind of one-touchization colloid system - Google Patents
A kind of one-touchization colloid system Download PDFInfo
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- CN107053521A CN107053521A CN201710414468.9A CN201710414468A CN107053521A CN 107053521 A CN107053521 A CN 107053521A CN 201710414468 A CN201710414468 A CN 201710414468A CN 107053521 A CN107053521 A CN 107053521A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B13/00—Conditioning or physical treatment of the material to be shaped
- B29B13/02—Conditioning or physical treatment of the material to be shaped by heating
- B29B13/022—Melting the material to be shaped
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/077—Manufacturing capsule shells
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B13/00—Conditioning or physical treatment of the material to be shaped
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B13/00—Conditioning or physical treatment of the material to be shaped
- B29B2013/005—Degassing undesirable residual components, e.g. gases, unreacted monomers, from material to be moulded
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Abstract
The invention discloses a kind of one-touchization colloid system, the system includes PLC, vacuum system, pressure transmitter, compression system, breather valve, foam probe, temperature transmitter, hot-water heating system, pressure switch, frequency converter, stirring system, weight transmitter, CIP valves, outlet valve, inlet valve, change glue tank, pneumatic operated valve and control software, wherein online weight is sent to PLC by weight transmitter, and inlet valve and outlet valve are controlled by PLC；Temperature of charge is sent to PLC by temperature transmitter, is supplied water and is cut off the water by PLC control hot-water heating systems；The pressure inside the tank for changing glue tank is sent to PLC by pressure transmitter, and vacuum system, compression system and breather valve are controlled by PLC；BOOL types bubble position signal is sent to PLC by foam probe, and breather valve and vacuum system are controlled by PLC；BOOL type signals are transmitted to PLC by pressure switch, and PLC judges whether to run or interrupts execution pneumatic operated valve action command；Frequency converter transmits a signal to PLC, and PLC is controlled by frequency converter to stirring system.
Description
Technical field
The present invention relates to soft capsule production technical field, and in particular to a kind of one-touchization colloid system.
Background technology
Soft capsule belongs to a kind of manner of packing of capsule, which because adverse drug odor can be covered, and improves medicine
Stability, bioavailability is high, and content homogeneity is good, and content deviation is very low, is obtained in medicine and field of health care food
It is widely applied, especially because the change of form of medication, has greatly promoted the development of China's traditional Chinese medicine.
Soft capsule is made up of capsule skin and content two parts, and capsule skin is mainly made up of capsule material, plasticizer, water.The system of capsule skin
Standby commonly referred to as to change glue, resulting product is referred to as glue.It is the crucial process and Quality Control Links of soft capsule one to change glue, is related to
It is the combination of a series of complex physical process to heating for dissolving, mixing, deaeration, strand reconstruct.
Current flexible glue encapsulated gluing equipment both domestic and external, it is substantially manually operated, wholeization glue is completed by one-touch
The automated system of process does not occur also, and standardization and the operation of unmannedization glue are being currently block blank.This situation is unfavorable for
Strengthen consumer confidence, be unfavorable for enterprise and realize intelligence manufacture, be unfavorable for regulator and build remote monitoring grid, traditional mode of production
Mode wastes the substantial amounts of manpower and materials of entire society.
The content of the invention
In order to overcome problems of the prior art, the present invention provides a kind of one-touchization colloid system, one-touchization
Colloid system is by control software, each operating procedure of automatic control glue, monitoring and control temperature, pressure, speed of agitator and
The technological parameters such as time, weight, realize standardization, automation, manless production.
To achieve the above object, one-touchization colloid system of the present invention include PLC, vacuum system, pressure transmitter,
Compression system, breather valve, foam probe, temperature transmitter, hot-water heating system, pressure switch, frequency converter, stirring system, weight
Transmitter, CIP valves, outlet valve, inlet valve, change glue tank, pneumatic operated valve and control software, the agitator wherein in stirring system are set
In glue tank is changed, pressure transmitter, breather valve, pneumatic operated valve, foam probe, temperature transmitter, pressure switch, frequency converter, again
Transmitter, CIP valves, outlet valve, inlet valve, on being arranged at glue tank；Online weight is sent to PLC by weight transmitter,
Inlet valve and outlet valve are controlled by PLC；Temperature of charge is sent to PLC by temperature transmitter, by PLC control hot-water heating system supply water and
Cut off the water；The pressure inside the tank for changing glue tank is sent to PLC by pressure transmitter, and vacuum system, compression system and breathing are controlled by PLC
Valve；BOOL types bubble position signal is sent to PLC by foam probe, and breather valve and vacuum system are controlled by PLC；Pressure switch will
BOOL type signals are transmitted to PLC, and PLC judges whether to run or interrupts execution pneumatic operated valve action command；Frequency converter is transmitted a signal to
PLC, PLC are controlled by frequency converter to stirring system；
Described control software includes password management system, formulation management system, weight control system, temperature control system, true
Empty control system, mixing control system, deaeration control system, control pressurer system, CIP on-line cleaning systems, controlling alarm system
System, measurement calibration system, time calibration system, data record and output system；
Wherein password management system distributes personnel's passwords at different levels by system manager, different with execution by password login system
The operation of authority；
Formulation management system follows the principle that equipment and production process are separated, using the control model of formula driving equipment, production
All technological parameters and functional module of product and the completion product are designed by user；
Weight control system passes through online weighing, control feedstock amount, load, monitoring vacuum leak amount, it is ensured that material weight
The accuracy of amount；Control CIP on-line cleaning hot water weight；
The accuracy of temperature when temperature control system ensures the supply of technique hot water and changes glue, while preventing excessive temperature to glue
Cause irreversible breaking；
Vacuum-control(led) system is used for the vacuum defoamation and the vacuum leak hunting of equipment of the vacuum feeding, glue of raw material；
Mixing control system accelerates dissolution of raw material mixing and the rising of glue bubble by controlling rotating speed and the time of agitator；
Deaeration control system is used to detect and control the lifting height of foam during vacuum defoamation, it is to avoid material is by vacuum intake line
In, cause vacuum tube and equipment to block and material loss；
Control pressurer system is used for airtight test and pressurization discharges, while preventing air pressure is too high from being damaged to equipment；
CIP on-line cleaning systems are used for the cleaning for changing glue tank；
Alarm control system is used for overload alarm, the rapid wear of urgent-stop alarm, the overload-alarm of equipment, public medium and procedure parameter
Part and cleaning elements maintenance maintenance early warning；
Measuring calibration system is used for the input of various transmitter calibration values, reduces measurement error；
Time calibration system is used for the calibration of system time；
Data record and output system can be recorded to the action that is related to, procedure parameter, and can be stored and be exported and remembered
The data of record.
Described password management system uses three-level Password Management, and different brackets possesses different rights, when user's input is stepped on
When recording password, password management system is verified to login password, if correctly, into the operation of corresponding authority, if wrong
By mistake, password need to be re-entered；When continuous three input errors of same user cipher, system program is returned to original state, needs
Administrator right is wanted to unlock.
Described formulation management system follows the principle that equipment and production process are separated, using the control of formula driving equipment
Molding formula, the parameter and process that completionization glue is related to is divided into data block and movable block, is carried out certainly using two-dimentional sheet format
By combining, the operating procedure and achievement data generated by two-dimentional list number is performed one by one in order by PLC.
Described weight control system has peeling zero setting function, error-disable function, quantitative discharging function and fault tolerance, its
Before middle peeling zero setting function is fingering raw material, the weight of original equipment system is removed the peel into zero setting；Error-disable function refers to that detection adds in real time
Data are sent to PLC by the raw material or the gravimetric value of medium entered in real time, to control related automatic feed valve, prevent certain material
Addition is very few or excess；Quantitative discharging function refers to by default load, precisely discharges；Fault tolerance refers to enter by material
The tolerance value gone out, license performs next step operation.
Described temperature control system is used to control temperature in temperature in technique heating medium temperature and tank, tank to divide by process
To throw gelatin temperature, glue temperature and drop temperature.
Described vacuum-control(led) system is used for the vacuum defoamation and the vacuum leak hunting of equipment of the vacuum feeding, glue of raw material；
The vacuum feeding of wherein raw material is that vacuum suction material enters tank, reduces artificial operation and airborne dust；The vacuum defoamation of glue is to pass through
The external pressure of bubble is reduced, when bubble inner pressure is more than external pressure and surface tension, bubbles burst takes off the bubble in glue；Equipment
Vacuum leak hunting be to check device systems airtight integrity under vacuum conditions, judge whether leakage point.
Described mixing control system accelerates dissolution of raw material mixing and glue gas by controlling rotating speed and the time of agitator
The rising of bubble；Described agitator is used to accelerate heat transfer and material mixing, and glue molecule is made while preventing local temperature too high
Into destruction；Speed setting value is converted into frequency by described mixing control system by PLC, frequency converter is sent to, by frequency converter
Corresponding electric voltage frequency is sent out to motor, the setting and control of rotating speed is completed；When timer inside PLC is to the operating of agitator
Between carry out timing.
Whether the signal that described deaeration control system is sensed by deaeration total time and calymma detector judges deaeration
Complete, when bubbles volume is not enough to trigger detectable signal, judged by the deaeration total time set；When calymma detector is detected
During signal, PLC judges whether deaeration completes with the sigtnal interval duration set.
Described control pressurer system is used for broken empty, the pressurization discharging of pressurization leakage detection, equipment and device interior cleaning purging, its
Middle pressurization leakage detection is the airtight integrity for checking device systems in the case where maintaining certain pressure, judges whether leakage point；Equipment
Broken sky is that equipment internal pressure is maintained into consistent with ambient exterior atmospheric pressure, is easy to provisional sampling and processing event.
The flow that described CIP on-line cleaning systems are purged using hot water, purified water cleaning and air, including hot water leaching
The step of bubble, hot water injection, purified water flushing and compressed air purging, wherein hot-water soak, are added after quantitative hot water, leaching
The bubble predetermined time, allow residual material to be completely dissolved in hot water, discharge clean afterwards, play destruction material structure and pasteurization
Effect；Hot water injection is that, in order to which the hydrotrope of non-emptying is rinsed well, it is to be rushed device interior with purified water that purified water, which is rinsed,
Wash clean, it is ensured that heavy metal free is remained, and compressed air purging is to be dried up device interior with compressed air, it is ensured that noresidue water,
Prevent bacteria breed.
Described alarm control system is designed with process alarm and predictive alarm, is divided into numeric type and Boolean type, is used for
Monitoringization gluing equipment and operating process, and defence program can be performed automatically, try to avert accidents.
One-touchization colloid system of the present invention determines operation by being formulated, by weighing, very during change glue
Sky, heating, stirring, deaeration, pressurization are accurately controlled, and realize standardization and Unmanned operation, and obtained glue is matched somebody with somebody
It is better than accurate, uniformity, it is ensured that the stability and controllability of following process.
Brief description of the drawings
Fig. 1 is the physical structure of the one-touchization colloid system.
Fig. 2 is the system framework figure of the one-touchization colloid system.
Fig. 3 is the system general flow chart of the one-touchization colloid system.
Fig. 4 is the Password Management flow chart of the one-touchization colloid system.
Fig. 5 is the formulation management flow chart of the one-touchization colloid system.
Fig. 6 is the PLC program flow chart of one embodiment of the one-touchization colloid system.
Fig. 7 is the Weight control flow chart of the one-touchization colloid system.
Fig. 8 is the temperature control flow figure of the one-touchization colloid system.
Fig. 9 is the vacuum control flow chart of the one-touchization colloid system.
Figure 10 is the mixing control flow chart of the one-touchization colloid system.
Figure 11 is the deaeration control flow chart of the one-touchization colloid system.
Figure 12 is the Stress control flow chart of the one-touchization colloid system.
Figure 13 is the CIP cleaning process figures of the one-touchization colloid system.
Figure 14 is the controlling alarm flow chart of the one-touchization colloid system.
Figure 15 is the measurement calibration flow chart of the one-touchization colloid system.
Figure 16 is the time calibration flow chart of the one-touchization colloid system.
Figure 17 is the data record and output flow chart of the one-touchization colloid system.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
As shown in Fig. 1 to Figure 17, one-touchization colloid system of the present invention includes PLC, vacuum system, pressure inverting
Device, compression system, breather valve, foam probe, temperature transmitter, hot-water heating system, pressure switch, frequency converter, stirring system, again
Transmitter, CIP valves, outlet valve, inlet valve, change glue tank, pneumatic operated valve and control software, the wherein agitator in stirring system are set
Put change glue tank in, pressure transmitter, breather valve, pneumatic operated valve, foam probe, temperature transmitter, pressure switch, frequency converter,
Weight transmitter, CIP valves, outlet valve, inlet valve（The inlet valve shown exemplary Fig. 2 includes water intaking valve, inlet valve and enters powder
Valve）On being arranged at glue tank；Online weight is sent to PLC by weight transmitter, and inlet valve and outlet valve are controlled by PLC；Temperature
Temperature of charge is sent to PLC by degree transmitter, is supplied water and is cut off the water by PLC control hot-water heating systems；Pressure transmitter will change glue tank
Pressure inside the tank is sent to PLC, and vacuum system, compression system and breather valve are controlled by PLC；Foam probe by bubble position signal
（BOOL types）PLC is sent to, breather valve and vacuum system are controlled by PLC；Pressure switch is by signal（BOOL types）It is transmitted to PLC, PLC
Judge whether to run or interrupt execution pneumatic operated valve action command；Frequency converter transmits a signal to PLC, and PLC is by frequency converter to stirring
The system of mixing is controlled；
Described control software includes password management system, formulation management system, weight control system, temperature control system, true
Empty control system, mixing control system, deaeration control system, control pressurer system, CIP（On-line cleaning）System, controlling alarm
System, measurement calibration system, time calibration system, data record and output system；
Wherein password management system distributes personnel's passwords at different levels by system manager, different with execution by password login system
The operation of authority；
Formulation management system follows the principle of " equipment and production process are separated ", using the control mould of " formula driving equipment "
Formula, all technological parameters and functional module of product and the completion product are designed by user, enhance device systems flexible；
Weight control system passes through online weighing, control feedstock amount, load, monitoring vacuum leak amount, it is ensured that material weight
The accuracy of amount；Control CIP on-line cleaning hot water weight；
The accuracy of temperature when temperature control system ensures the supply of technique hot water and changes glue, while preventing excessive temperature to glue
Cause irreversible breaking；
Vacuum-control(led) system one is the vacuum feeding for raw material, and two be the vacuum defoamation for glue, and three be for equipment
Vacuum leak hunting；
Mixing control system accelerates dissolution of raw material mixing and the rising of glue bubble by controlling rotating speed and the time of agitator；
Deaeration control system is used to detect and control the lifting height of foam during vacuum defoamation, it is to avoid material is by vacuum intake line
In, cause vacuum tube and equipment to block and material loss；
Control pressurer system is used for airtight test and pressurization discharges, while preventing air pressure is too high from being damaged to equipment；
CIP（On-line cleaning）System is used for the cleaning for changing glue tank；
Alarm control system is used for overload alarm, the rapid wear of urgent-stop alarm, the overload-alarm of equipment, public medium and procedure parameter
Part and cleaning elements maintenance maintenance early warning；
Measuring calibration system is used for the input of various transmitter calibration values, reduces measurement error；
Time calibration system is used for the calibration of system time；
Data record and output system can be recorded to the action that is related to, procedure parameter, and can be stored and be exported and remembered
The data of record.
Fig. 3 shows the system main-process stream of the one-touchization colloid system.After system initialization, user's input password leads to
Cross after system checking, into formulation management, after being formulated each key element selection and setting, system automatically generates process data, control ginseng
Number and execution sequence, completionization glue and cleaning.Afterwards, system can keeping records, and generate default list, may be output to simultaneously
External data exchange system.
Fig. 4 shows the Password Management flow of the one-touchization colloid system.Described password management system uses three-level
Password Management, different brackets possesses different rights, such as following table：
System is verified to login password, if correctly, into the operation of corresponding authority, if mistake, need to re-enter
Password.For ensure safety, when continuous three input errors of same user cipher, system program be returned to original state, it is necessary to
Administrator right could be unlocked.
Fig. 5 shows the formulation management flow of the one-touchization colloid system.Described formulation management system follows " equipment
With production process be separated " S88 standards, using the control model of " formula driving equipment ", the parameter that completionization glue is related to
It is divided into process：Data block and movable block, carry out independent assortment using two-dimentional sheet format, add the flexibility of production process
Change, strengthen the confidentiality of enterprise's technique.Such as following table：
Two-dimentional sheet format is as follows：
The operating procedure and achievement data generated by upper table, number is performed one by one in order by PLC.The maximum of formulation management system is special
Putting is：Allow user by different actions and the combination of data, find out the change adhesive process for meeting this enterprise optimization, later stage
Standardized；Further, since being participated in without external staff, the confidentiality of this commercial running adhesive process is enhanced.
The formulation data of user's input includes " serial number+movable block+data block ", and PLC presses default logical relation, equipment
Protection parameters etc. are checked, and such as produce conflict, then not perform, such as check errorless, next-step operation is performed automatically.
Fig. 6 shows the PLC program flow chart of one embodiment.In the embodiment, it is soft that so-and-so company need to prepare a batch
Capsule, glue formula ratio is 470 Kg, and component formula see the table below：
| Material name | Weight Kg | Accounting % |
| Purified water | 200 | 42.55 |
| Glycerine | 70 | 14.90 |
| Gelatin | 200 | 42.55 |
The two-dimentional list of the formula of the example：
Fig. 7 shows the Weight control flow of the one-touchization colloid system.Weight control system has following function：
1. zero setting function is removed the peel：Enter before raw material, the weight of original equipment system is removed the peel into zero setting；
2. error-disable function：Data are sent to PLC by detection is added in real time raw material or the gravimetric value of medium in real time, to control
The related automatic feed valve of system, prevents certain material addition very few or excess；
3. quantitative discharging function：By default load, precisely discharging；
4. fault tolerance：The tolerance value passed in and out by material, license performs next step operation.
In Fig. 7, left side is charging flow, and right side is discharging flow.
First charging（Raw material and rinse water）When, system peeling zero setting, PLC reads the preset weight set in formula, held
Traveling material is acted, when weight is not up to, and continues to feed.When reaching, next-step operation is performed.If continuing to feed, PLC reads lower step thing
The preset weight of material, is not required to remove the peel zero setting, directly performs charging action.
During discharging, PLC reads the discharging preset weight set in formula, and preset weight is compared with actual inventory
Compared with.If preset weight is less than actual inventory, system is determined as intermittent take-off, if preset weight is equal to actual inventory,
It is determined as connection discharging.Discharge total amount（Or accumulation amount）Meet after condition, be judged as that discharging is completed.
Fig. 8 shows the temperature control flow of the one-touchization colloid system.Change during glue, such as gelatin is more than 72 DEG C
When, it may occur that hydrolysis, its molecular structure is destroyed, and causes major quality accident, therefore temperature control is an important link.
Temperature is divided into temperature in temperature in technique heating medium temperature and tank, tank by detecting position and is divided into by process：Throw gelatin（Or other capsules
Material）Temperature, glue temperature, drop temperature.
Left side is temperature control flow in tank in Fig. 8, and right side is processing medium temperature control flow.
When enabling heating, heating system（Heater and water pump etc.）Open, when heating medium temperature reaches setting value, plus
Thermal is closed, and is a closed loop control process.
When changing glue, by the temperature index of each stage control, relevant action is performed.After glue temperature reaches setting value, plus
Thermal medium induction system is closed.
Fig. 9 shows the vacuum control flow of the one-touchization colloid system.Vacuum is mainly used in the airtight of device systems
Property check and process operations, division see the table below：
| Type | Using description |
| Vacuum leak hunting | The airtight integrity of device systems under vacuum conditions is checked, leakage point is judged whether. |
| Vacuum intake | Vacuum suction material enters tank, reduces artificial operation and airborne dust. |
| Vacuum defoamation | The external pressure of bubble is reduced, when bubble inner pressure is more than external pressure and surface tension, bubbles burst takes off the bubble in glue |
Left side is vacuum leak hunting flow in Fig. 9, and centre is vacuum intake flow, and right side is vacuum defoamation flow.
During vacuum leak hunting, open after the leak detection vacuum that setting is reached in vacuum system, tank, vacuum system is closed, PLC is pressed
The time internal drop measured value of setting, compared with defined pressure criteria pair, provides conclusion.
When vacuum inhales material, vacuum system is opened, and when vacuum reaches established standardses in tank, material is by vacuum suction tank
It is interior.
During vacuum defoamation, vacuum system works together with breather valve, calymma detector, by between the calymma signal that detects
Every with total inclined heated plate, PLC be made whether complete deaeration judgement.
Figure 10 shows the mixing control flow of the one-touchization colloid system.Agitator in the stirring system be for
Accelerate heat transfer and material mixing, while preventing local temperature too high glue molecule is damaged.Because of material during change glue
The torsional forces that state is produced is different, therefore agitator often uses transducer drive, it is to avoid overload and reduction vibrations.
Stir two parameters of general control rotating speed and time.Time defined here, there are a two types, one when being direct
Between, it is an integer, such as 60 minutes；Two be indirect dynamic time, that is, starts from certain somewhere T1, ends at certain somewhere T2, stirs
Mix time T=T2-T1.
As shown in Figure 10, PLC is speed setting value（Rev/min）It is converted into frequency（HZ）, frequency converter is sent to, by frequency conversion
Device sends out corresponding electric voltage frequency to motor, completes the setting and control of rotating speed.
PLC internal timers carry out timing, after the defined direct time reaches, agitator to the duration of runs of agitator
It is out of service.If stirring definition is the indirect dynamic time, PLC is run to behind the beginning somewhere of setting, by a M position
For " 1 ", stirring is opened, to after the end somewhere of setting, M are reset to " 0 ", stirring stops.
Figure 11 shows the deaeration control flow of the one-touchization colloid system.During glue is changed, due to jelly powder（Or
Other capsule materials）For graininess（Powdery）, have some air pockets, and because containing air in purified water, brought sky during vacuum intake into again
Gas, therefore there is large quantity of air in material system.When capsule material raw molecule is heated with water molecules reconstruct, air can be squeezed
Go out, there is the bubble of a large amount of needle-like before non-deaeration, in glue, this bubble is commonly called as calymma.Calymma can seriously reduce the jelly of rubber
Power, and the harmony of film forming is destroyed, rupture and leakage and oxidative rancidity can occur for the soft capsule produced, cause content to pollute and property
It can fail, it is impossible to list.
Current way is vacuum defoamation at present, and the pressure on calymma surface is reduced using vacuum, when calymma inside and outside differential pressure is super
When crossing its surface tension, calymma Natural Ruptures are eliminated, and improve glue quality.
As shown in figure 11, judge whether deaeration completes, rely primarily on the letter that deaeration total time and calymma detector are sensed
Number, when bubbles volume is not enough to trigger detectable signal, judged by the deaeration total time set；When a signal has been detected, PLC with
The sigtnal interval duration of setting judges whether deaeration completes.
Figure 12 shows the Stress control flow of the one-touchization colloid system.Stress control is used for pressurization leakage detection, equipment
Broken empty, pressurization discharging and device interior cleaning purging, function see the table below：
| Type | Using description |
| Pressurization leakage detection | Airtight integrity of the device systems in the case where maintaining certain pressure is checked, leakage point is judged whether. |
| The broken sky of equipment | Equipment internal pressure is remained consistent with ambient exterior atmospheric pressure, is easy to provisional sampling and processing event etc.. |
| Pressurization discharging | It is gravity discharging when desired value is 0, when being non-zero value, for pressurization discharging. |
| Pressure limit | When performing leak detection, discharging and air purging, all pressure indexs must not be higher than the pressure License Value of apparatus body. |
In Figure 12, left side is pressurization flow, and right side is broken empty flow.
During pressurization, the real-time pressure value of PLC detection pressure transmitter transmission, when reaching setup pressure value, pressurizing valve is closed.For
Prevent pressurizing valve is damaged from causing device systems overvoltage, PLC continues to detect real-time pressure, when real-time pressure exceeds the apparatus body limit
During pressure, breather valve is opened.
Because pressure transmitter has measurement error, so broken sky typically uses time control, it is ensured that safety.
Figure 13 shows the CIP cleaning processes of the one-touchization colloid system.After the completion of plastic emitting, equipment and material contact site
Needs are divided to clean up, in case lower batch of production.Because raw material and product possess high-temperature water-soluble, thus it is clear using hot water, purified water
The flow purged with air is washed, whole flow process is to be referred to as CIP in online completion, industry（Cleanning in Place）.Tool
Body flow such as following table：
| Cleaning sequence | Step title | Process description |
| 1 | Hot-water soak | Add after quantitative hot water, soak certain time, allow residual material to be completely dissolved in hot water, discharge clean afterwards.Play destruction material structure and pasteurization effect. |
| 2 | Hot water injection | The hydrotrope of non-emptying is rinsed well. |
| 3 | Purified water is rinsed | Device interior is rinsed well with purified water, it is ensured that heavy metal free is remained. |
| 4 | Compressed air purging | Device interior is dried up with compressed air, it is ensured that noresidue water, prevent bacteria breed. |
As shown in figure 13, when performing CIP cleanings, PLC reads parameter preset, by the Con trolling index and cleaning route of design, a step
Step is performed.After the completion of, PLC sends end signal, and is used as the necessary condition for performing the operation of next timeization glue.
Figure 14 shows the controlling alarm flow of the one-touchization colloid system.The present invention is designed with process alarm and indication
Property alarm, be divided into numeric type and Boolean type, for monitoringization gluing equipment and operating process, and necessary protection journey can be performed automatically
Sequence, tries to avert accidents.It see the table below：
Left side is numeric type alarm flow in Figure 14, and right side is Boolean type fault alarm flow.
Numeric type includes temperature, pressure, weight, time etc., and Boolean type is the electric signals, PLC roots such as phase shortage, overload, jerk
According to the alarm rule set, necessary protection is alarmed and performed in output.
Figure 15 shows the measurement calibration flow of the one-touchization colloid system.
Be present certain error in measuring instrument, need to be verified by master meter, and the deviation after verification is, it is necessary to be input to
In PLC, the right value of the transmitter is obtained.
The calibration of instrument is, it is necessary to which specific authority, is typically performed by keeper and director.
As shown in figure 15, after user inputs login password by checking, the deviation of each measuring instrument is inputted, PLC is automatic
It is compensated by.
Figure 16 shows the time calibration flow of the one-touchization colloid system.
Due to the precision problem of PLC internal system times, as systems stay is run, error can be produced, need to by calibration,
With extraneous time synchronized.
Time calibration can also pass through time calibration in network by being manually entered.
The calibration of time is, it is necessary to which specific authority, is typically performed by keeper and director.
As shown in figure 16, after user inputs login password by checking, current time is inputted, PLC gives adjust automatically.
In the case of connection server, select synchronous with server time, then when the current time of server is covered inside PLC automatically
Between.
Figure 17 shows the data record and output flow of the one-touchization colloid system.During data including glue
Operator's identity, parameter, action and alarm, be made up of body of data and time.According to the requirement of Chinese GMP dates backs,
These data are both needed to be recorded and preserved.After PLC operation output programs, data output to external system（Such as mobile storage
Medium, printer, host computer etc.）.
In Figure 17, left side is data record flow, and right side is record output flow.
When PLC is run, all data are automatically recorded, when recording number more than internal memory, system alarm, and temporally
Sequentially, new record covers old record automatically.
, can be by the record in certain Rule Extraction PLC during user's selection output.Output record needs certain authority, typically
Specify keeper and director.
Control software of the present invention uses Siemens's STL language designs, can facilitate between S7 200 and above PLC
Transplanting.Interface design using RS-485 and（Or）RJ45 accesses PLC, is downloaded or uploads.The main authority that passes through of the invention is divided
Match somebody with somebody, predetermined operation authority, by formulation management system, by user's self assemble movable block and data block, generation operation order and
Con trolling index, completes wholeization glue process.All data can be recorded, and can be exported.
Control software requirement of the present invention can be by computer off-line test, and testing content includes：Formulation data is complete
Property test, interface testing, integration testing, functional test, performance evaluating and load testing in terms of, until meet demand.
Described controlling software design has remedial measure during software faults.When formulation data is space-time, it is impossible to which progressization glue is grasped
Make, user must be defined and select to formula items, can execution glue.Software does a backup, when PLC program is lost,
PLC recoveries are downloaded to backup.
Described control software is simple to operate in itself, and occupancy resource is few, only back-up processing need to be carried out to software, to ensure journey
Sequence is not lost.
Although above with general explanation and specific embodiment, the present invention is described in detail, at this
On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore,
These modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
1. a kind of one-touchization colloid system, it is characterised in that the one-touchization colloid system includes PLC, vacuum system, pressure and become
Send device, compression system, breather valve, foam probe, temperature transmitter, hot-water heating system, pressure switch, frequency converter, stirring system,
Weight transmitter, CIP valves, outlet valve, inlet valve, change glue tank, pneumatic operated valve and control software, the wherein agitator in stirring system
In being arranged on glue tank, pressure transmitter, breather valve, pneumatic operated valve, foam probe, temperature transmitter, pressure switch, frequency conversion
Device, weight transmitter, CIP valves, outlet valve, inlet valve, on being arranged at glue tank；Online weight is sent to by weight transmitter
PLC, inlet valve and outlet valve are controlled by PLC；Temperature of charge is sent to PLC by temperature transmitter, is supplied by PLC control hot-water heating systems
Water and cut off the water；The pressure inside the tank for changing glue tank is sent to PLC by pressure transmitter, is controlled vacuum system, compression system by PLC and is exhaled
Inhale valve；BOOL types bubble position signal is sent to PLC by foam probe, and breather valve and vacuum system are controlled by PLC；Pressure switch
BOOL type signals are transmitted to PLC, PLC judges whether to run or interrupts execution pneumatic operated valve action command；Frequency converter transmits signal
Stirring system is controlled by frequency converter to PLC, PLC；
Described control software includes password management system, formulation management system, weight control system, temperature control system, true
Empty control system, mixing control system, deaeration control system, control pressurer system, CIP on-line cleaning systems, controlling alarm system
System, measurement calibration system, time calibration system, data record and output system；
Wherein password management system distributes personnel's passwords at different levels by system manager, different with execution by password login system
The operation of authority；
Formulation management system follows the principle that equipment and production process are separated, using the control model of formula driving equipment, production
All technological parameters and functional module of product and the completion product are designed by user；
Weight control system passes through online weighing, control feedstock amount, load, monitoring vacuum leak amount, it is ensured that material weight
The accuracy of amount；Control CIP on-line cleaning hot water weight；
The accuracy of temperature when temperature control system ensures the supply of technique hot water and changes glue, while preventing excessive temperature to glue
Cause irreversible breaking；
Vacuum-control(led) system is used for the vacuum defoamation and the vacuum leak hunting of equipment of the vacuum feeding, glue of raw material；
Mixing control system accelerates dissolution of raw material mixing and the rising of glue bubble by controlling rotating speed and the time of agitator；
Deaeration control system is used to detect and control the lifting height of foam during vacuum defoamation, it is to avoid material is by vacuum intake line
In, cause vacuum tube and equipment to block and material loss；
Control pressurer system is used for airtight test and pressurization discharges, while preventing air pressure is too high from being damaged to equipment；
CIP on-line cleaning systems are used for the cleaning for changing glue tank；
Alarm control system is used for overload alarm, the rapid wear of urgent-stop alarm, the overload-alarm of equipment, public medium and procedure parameter
Part and cleaning elements maintenance maintenance early warning；
Measuring calibration system is used for the input of various transmitter calibration values, reduces measurement error；
Time calibration system is used for the calibration of system time；
Data record and output system can be recorded to the action related to and procedure parameter, and can be stored and be exported and remembered
The data of record.
2. one-touchization colloid system as claimed in claim 1, it is characterised in that described password management system is close using three-level
Code management, different brackets possesses different rights, and when user inputs login password, password management system is tested login password
Card, if correctly, into the operation of corresponding authority, if mistake, password need to be re-entered；When same user cipher continuous three
During secondary input error, system program is returned to original state, it is necessary to which administrator right could be unlocked.
3. one-touchization colloid system as claimed in claim 1, it is characterised in that described formulation management system follow equipment and
The principle that production process is separated, using the control model of formula driving equipment, the parameter and process that completionization glue is related to are drawn
It is divided into data block and movable block, independent assortment is carried out using two-dimentional sheet format, the operating procedure generated by two-dimentional list and referred to
Data are marked, number are performed one by one in order by PLC.
4. one-touchization colloid system as claimed in claim 1, it is characterised in that described weight control system is put with peeling
Zero power energy, error-disable function, quantitative discharging function and fault tolerance, wherein before peeling zero setting function is fingering raw material, by original equipment
The weight peeling zero setting of system；Error-disable function refers to the gravimetric value of the raw material that detection is added in real time or medium, and data are passed in real time
PLC is sent to, to control related automatic feed valve, prevents certain material addition very few or excess；Quantitative discharging function refer to by
Default load, precisely discharging；Fault tolerance refers to the tolerance value passed in and out by material, and license performs next step operation.
5. one-touchization colloid system as claimed in claim 1, it is characterised in that described temperature control system is used to control work
Temperature is divided into throwing gelatin temperature, glue temperature and drop temperature by process in temperature in skill heating medium temperature and tank, tank；
Described vacuum-control(led) system is used for the vacuum defoamation and the vacuum leak hunting of equipment of the vacuum feeding, glue of raw material；Wherein
The vacuum feeding of raw material is that vacuum suction material enters tank, reduces artificial operation and airborne dust；The vacuum defoamation of glue is by reduction
The external pressure of bubble, when bubble inner pressure is more than external pressure and surface tension, bubbles burst takes off the bubble in glue；Equipment it is true
Sky leak detection is to check the airtight integrity of device systems under vacuum conditions, judges whether leakage point.
6. the one-touchization colloid system as described in any one of claim 1 to 5, it is characterised in that described mixing control system
By controlling rotating speed and the time of agitator, accelerate dissolution of raw material mixing and the rising of glue bubble；Described agitator is used for
Accelerate heat transfer and material mixing, glue molecule is damaged while preventing local temperature too high；Described mixing control system
Speed setting value is converted into by PLC by frequency, frequency converter is sent to, corresponding electric voltage frequency is sent out to motor by frequency converter,
Complete the setting and control of rotating speed；Timer inside PLC carries out timing to the duration of runs of agitator.
7. one-touchization colloid system as claimed in claim 1, it is characterised in that described deaeration control system is total by deaeration
The signal that time and calymma detector are sensed judges whether deaeration completes, when bubbles volume is not enough to trigger detectable signal, by
The deaeration total time of setting judges；When calymma detector detects signal, PLC is judged with the sigtnal interval duration set
Whether deaeration completes.
8. one-touchization colloid system as claimed in claim 1, it is characterised in that described control pressurer system, which is used to pressurize, to be examined
Leakage, broken empty, the pressurization discharging of equipment and device interior cleaning purging, wherein pressurization leakage detection is to check that device systems are maintaining a level pressure
Airtight integrity under power, judges whether leakage point；It is to maintain equipment internal pressure and ambient exterior atmospheric pressure one that equipment, which breaks sky,
Cause, be easy to provisional sampling and processing event.
9. one-touchization colloid system as claimed in claim 1, it is characterised in that described CIP on-line cleaning systems are using heat
The flow of water, purified water cleaning and air purging, including hot-water soak, hot water injection, purified water flushing and compressed air purging
The step of, wherein hot-water soak is added after quantitative hot water, is soaked the predetermined time, is allowed residual material to be completely dissolved in heat
Water, discharges clean, plays destruction material structure and pasteurization effect afterwards；Hot water injection is in order to by the hydrotrope of non-emptying
Rinse well, it is to be rinsed well device interior with purified water that purified water, which is rinsed, it is ensured that heavy metal free is remained, compressed air purging
It is to be dried up device interior with compressed air, it is ensured that noresidue water, prevents bacteria breed.
10. one-touchization colloid system as claimed in claim 1, it is characterised in that described alarm control system was designed with
Journey is alarmed and predictive alarm, is divided into numeric type and Boolean type, for monitoringization gluing equipment and operating process, and can be held automatically
Row defence program, tries to avert accidents.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710414468.9A CN107053521A (en) | 2017-06-05 | 2017-06-05 | A kind of one-touchization colloid system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710414468.9A CN107053521A (en) | 2017-06-05 | 2017-06-05 | A kind of one-touchization colloid system |
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