CN107028816A - Ozone vegetable oil emulsifier composition for toothpaste and preparation method thereof - Google Patents
Ozone vegetable oil emulsifier composition for toothpaste and preparation method thereof Download PDFInfo
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- CN107028816A CN107028816A CN201710429782.4A CN201710429782A CN107028816A CN 107028816 A CN107028816 A CN 107028816A CN 201710429782 A CN201710429782 A CN 201710429782A CN 107028816 A CN107028816 A CN 107028816A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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Abstract
The present invention discloses a kind of for ozone vegetable oil emulsifier composition of toothpaste and preparation method thereof, it is related to daily chemical products additive technology field, it can not be embodied as the effect of oral cavity oxygen supply to improve existing emulsifying agent, and to oral cavity bactericidal antiphlogistic and remove the poor technical problem of calculus dentalis effect.According to percent by weight, the present invention is mainly prepared for the ozone vegetable oil emulsifier composition of toothpaste by following components：Ozone vegetable oil 20 40%, emulsifying agent 8 20%, water 20 40%, rubbing agent 30 50%.The present invention also provides the preparation method of the ozone vegetable oil emulsifier composition for toothpaste, and this method dissolves each component the ozone vegetable oil emulsifier composition being made after mixing for toothpaste, simple with method, the advantages of product quality is good.In being prepared present invention is mainly applied to the production of the ozone vegetable oil emulsifier composition for toothpaste.
Description
Technical field
The present invention relates to daily chemical products additive technology field, in particular to a kind of ozone plant for toothpaste
Emulsifier composition and preparation method thereof.
Background technology
With the offer of living standard, domestic and international cosmetics and washing product consumption market comes into a new development
Climax, Related product constantly upgrading is with updating, and emulsifying agent is then essential composition in these products.
Emulsifying agent is that one kind can make the oily matters such as fat, vegetable oil, wax and hydroaropic substance be mixed to form stabilization
The material of mixture, belongs to a class of surfactant.In washing product, emulsifying agent is usually used in manufacture cream, emulsion and soft
Cream, can effectively ensure that the stability of product property.Emulsifying agent is generally added in toothpaste, for ensureing that tooth paste product property is steady
It is fixed, help to remove the food remained in oral cavity.However, the effect of oral cavity oxygen supply can not be embodied as in existing toothpaste, and it is right
Effect of sterilizing oral anti-inflammatory and removing calculus dentalis is poor.
In view of this, it is special to propose the present invention.
The content of the invention
First purpose of the present invention is to provide a kind of ozone vegetable oil emulsifier composition for toothpaste, to improve
Existing emulsifying agent can not be embodied as the effect of oral cavity oxygen supply, and to oral cavity bactericidal antiphlogistic and remove the poor skill of calculus dentalis effect
Art problem.
Second object of the present invention is to provide a kind of preparation method of mentioned emulsifier composition, the letter of this method process
It is single and easily operated, it is ensured that each component can fully participate in reaction, obtain steady quality, the ozone for toothpaste of uniform properties
Vegetable oil emulsifier composition.
In order to realize the above-mentioned purpose of the present invention, spy uses following technical scheme：
The present invention provides a kind of ozone vegetable oil emulsifier composition for toothpaste, according to percent by weight, mainly
Prepared by following components：Ozone vegetable oil 20-40%, emulsifying agent 8-20%, water 20-40%, rubbing agent 30-50%.
Alternatively, according to percent by weight, the ozone vegetable oil emulsifier of the present invention for toothpaste combines owner
To be prepared by following components：Ozone vegetable oil 21-39%, emulsifying agent 9-19%, water 21-38%, rubbing agent 31-49%.
Alternatively, according to percent by weight, the ozone vegetable oil emulsifier of the present invention for toothpaste combines owner
To be prepared by following components：Ozone vegetable oil 25-35%, emulsifying agent 10-18%, water 25-35%, rubbing agent 35-45%.
Alternatively, according to percent by weight, the ozone vegetable oil emulsifier composition of the present invention for toothpaste
Component also includes adhesive 1-2%, foaming agent 2-8%, essence 0.5-2%.
Alternatively, the ozone vegetable oil include ozone soybean oil, ozone olive oil, ozone rapeseed oil, ozone corn oil,
One or more in ozone tea-seed oil or ozone sunflower oil.
Alternatively, the emulsifying agent include tween, oleic acid, sorbitan trioleate, sorbitan monooleate,
In methyl glycol fatty acid ester, glycerin monostearate, glycerin mono-fatty acid ester, two monooleins or isostearic acid monoglyceride
One or more；The rubbing agent includes Calcium Phosphate, Dibasic Dihydrate, calcium pyrophosphate, precipitated silica, silicate hydrate, three hydrations
One or more in Alpha-alumina or aluminium hydroxide.
Alternatively, the adhesive revolves sour sodium, polyvinyl alcohol including sodium carboxymethylcellulose, hydroxyethyl cellulose, algae, gathered
One or more in propylene phthalein amine or silica.
Alternatively, the foaming agent include sldium lauryl sulfate, N- laurate sodium sarcosinate, bay phthalein sulfoacetic acid sodium or
One or more in dioctyl sodium sulphosuccinate.
The present invention also provides a kind of preparation method of the ozone vegetable oil emulsifier composition for toothpaste, including such as
Lower step：After ozone vegetable oil, emulsifying agent and water are heated respectively, water and emulsifying agent are added in ozone vegetable oil while stirring
And be incubated；Rubbing agent, adhesive, foaming agent and essence are added after cooling, stirs and is obtained after cooling for toothpaste
Ozone vegetable oil emulsifier composition.
Alternatively, in the preparation method of the present invention for the ozone vegetable oil emulsifier composition of toothpaste, heating temperature
Spend for 65-80 DEG C, soaking time is 1-2h, the temperature after cooling is less than 40 DEG C.
Compared with prior art, beneficial effects of the present invention are：
(1) present invention is in the ozone vegetable oil emulsifier composition of toothpaste, regarding ozone vegetable oil as primary efficacy
Composition is used cooperatively with emulsifying agent and water, then is aided with rubbing agent, adhesive, foaming agent and essence, and each component is according to scientific matching
Combine, generate positive synergy, suitable oxygen can be provided when brushing teeth for oral cavity, while also having good
Good effect to oral cavity bactericidal antiphlogistic and removing calculus dentalis.
(2) present invention uses the side of batch charging for the preparation method of the ozone vegetable oil emulsifier composition of toothpaste
Method, first heats ozone vegetable oil, emulsifying agent and water respectively, then while stirring adds water and emulsifying agent in ozone vegetable oil
And be incubated, rubbing agent, adhesive, foaming agent and essence are added after cooling and is stirred, is obtained after cooling for toothpaste
Ozone vegetable oil emulsifier composition, this method process is simple and easily operated, it is considered to which the dissolubility and thermal sensitivity of each component are each
Differ there is provided preferably dissolution system and reaction temperature, ensure that each component fully participates in reaction, obtain quality steady
Fixed, the ozone vegetable oil emulsifier composition for toothpaste of uniform properties.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment or embodiment, but this area skill
Art personnel will be understood that following embodiments or embodiment are merely to illustrate the present invention, and are not construed as the model of the limitation present invention
Enclose.Unreceipted actual conditions person in embodiment or embodiment, the condition advised according to normal condition or manufacturer is carried out.It is used
Reagent or the unreceipted production firm person of instrument, are the conventional products that can be obtained by commercially available purchase.
" mainly by ... " described in embodiment of the present invention, it is intended that it can also include other in addition to the component
Component, these other components assign the ozone vegetable oil emulsifier composition for toothpaste different characteristics.In addition,
" mainly by ... " described in embodiment of the present invention, may be replaced by enclosed " being " or " by ... ".
According to an aspect of the present invention, embodiment of the present invention provides a kind of ozone vegetable oil emulsifier for toothpaste
Composition, according to percent by weight, is mainly prepared by following components：Ozone vegetable oil 20-40%, emulsifying agent 8-
20%, water 20-40%, rubbing agent 30-50%.
In the ozone vegetable oil emulsifier composition for toothpaste that embodiment of the present invention is provided, ozone vegetable oil is made
Used cooperatively for main composition with emulsifying agent and water, then be aided with rubbing agent, adhesive, foaming agent and essence, each component is pressed
Combined according to scientific matching, generate positive synergy, suitable oxygen can be provided for oral cavity when brushing teeth, together
When also have effects that good to oral cavity bactericidal antiphlogistic and to remove calculus dentalis.
Specifically, ozone vegetable oil is also referred to as ozonisation vegetable oil or ozone solidified plant oil, is to solidify skill using ozone
A kind of pure natural mixture that pure ozone is cured to first squeezing plant oil and generated by art.
Preferably, in ozone vegetable oil the content of ozonide in 60-80g/L.
Alternatively, ozone vegetable oil is the commercially available prod of purchase.
Alternatively, in embodiments of the present invention, it is purified water that water used is typical but non-limiting.
Alternatively, it is 20% that the percetage by weight of ozone vegetable oil is typical but non-limiting, 21%, 22%, 23%,
24%th, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%,
39% or 40%.
Alternatively, it is 8% that the percetage by weight of emulsifying agent is typical but non-limiting, 9%, 10%, 11%, 12%, 13%,
14%th, 15%, 16%, 17%, 18%, 19% or 20%.
Alternatively, it is 20% that the percetage by weight of water is typical but non-limiting, 21%, 22%, 23%, 24%, 25%,
26%th, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39% or 40%.
Alternatively, it is 30% that the percetage by weight of rubbing agent is typical but non-limiting, 31%, 32%, 33%, 34%,
35%th, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49% or
50%.
Alternatively, the ozone vegetable oil emulsifier composition for toothpaste that embodiment of the present invention is provided, according to weight
Percentage meter, is mainly prepared by following components：Ozone vegetable oil 21-39%, emulsifying agent 9-19%, water 21-38%, friction
Agent 31-49%.
, being capable of ozone trials of emulsion of plant oil of the reasonable adjusting for toothpaste by further adjustment and the optimization of the content to each component
Thick dilute degree of agent composition, and the ozone vegetable oil emulsifier composition for toothpaste is further enhanced to sterilizing oral
Anti-inflammatory and the effect of oxygen supply, more effectively remove calculus dentalis, protect the health of one's mouth.
Alternatively, the ozone vegetable oil emulsifier composition for toothpaste that embodiment of the present invention is provided, according to weight
Percentage meter, is mainly prepared by following components：Ozone vegetable oil 25-35%, emulsifying agent 10-18%, water 25-35%, rub
Liniment 35-45%.
Alternatively, according to percent by weight, the ozone vegetable oil for toothpaste that embodiment of the present invention is provided is emulsified
The component of agent composition also includes adhesive 1-2%, foaming agent 2-8%, essence 0.5-2%.
Gluing is also provided in the ozone vegetable oil emulsifier composition for toothpaste provided due to embodiment of the present invention
Agent, foaming agent and essence, therefore, it is possible to effectively improve the stability of the ozone vegetable oil emulsifier composition for toothpaste, outward appearance
It is finer and smoother, while can also have more pleasant fragrance, it is easier to liked by user.
Alternatively, it is daily chemical essence, such as material with the fragrance of a flower or fruity that essence is typical but non-limiting；Preferably,
Essence is caryophyllus oil, orange oil, cinnamon oil or Rosa Damascana.
Alternatively, it is 1%, 1.2%, 1.5%, 1.7% or 2% that the percetage by weight of adhesive is typical but non-limiting.
By adding the adhesive of Optimum Contents, the ozone vegetable oil emulsifier composition for toothpaste can effectively ensure that
With suitable viscosity and higher stability, prevent from isolating moisture.
Alternatively, it is 2% that the percetage by weight of foaming agent is typical but non-limiting, 2.2%, 2.5%, 2.7%, 3%,
3.5%th, 4%, 4.5%, 5%, 5.5%, 6%, 6.5%, 7%, 7.5% or 8%.
By the foaming agent for adding Optimum Contents, it is possible to increase for toothpaste ozone vegetable oil emulsifier composition it is clear
Clean and foaming capacity, while rapid diffusion, is conducive to sending the fragrance of essence.
Alternatively, it is 0.5% that the percetage by weight of essence is typical but non-limiting, 0.7%, 1%, 1.2%, 1.5%,
1.7% or 2%.
Alternatively, in the ozone vegetable oil emulsifier composition for toothpaste that embodiment of the present invention is provided, ozone is planted
Thing oil includes ozone soybean oil, ozone olive oil, ozone rapeseed oil, ozone corn oil, ozone tea-seed oil or ozone sunflower oil
In one or more.
In the present invention, ozone soybean oil is referred to as ozonisation soybean oil or ozone solidification soybean oil, ozone olive
Oil is referred to as ozonisation olive oil or ozone solidification olive oil, and ozone rapeseed oil is referred to as ozonizing rapeseed oil or smelly
Oxygen solidifies rapeseed oil, and ozone corn oil is referred to as ozonisation corn oil or ozone solidification corn oil, and ozone tea-seed oil also may be used
To be referred to as ozonizing tea-seed oil or ozone solidification tea-seed oil, ozone sunflower oil is referred to as ozonisation sunflower oil or ozone
Solidify sunflower oil.
Preferably, in the ozone vegetable oil emulsifier composition for toothpaste that embodiment of the present invention is provided, ozone is planted
Thing oil it is typical but it is non-limiting for ozone soybean oil, it is ozone olive oil, ozone rapeseed oil, ozone corn oil, ozone tea-seed oil, smelly
Combination, the combination of ozone rapeseed oil and ozone corn oil, ozone corn oil and the ozone tea seed of oxygen soybean oil and ozone olive oil
The combination of oil or the combination of ozone sunflower oil and ozone soybean oil.
Alternatively, in the ozone vegetable oil emulsifier composition for toothpaste that embodiment of the present invention is provided, emulsifying agent
It is sweet including tween, oleic acid, sorbitan trioleate, sorbitan monooleate, methyl glycol fatty acid ester, monostearate
One or more in grease, glycerin mono-fatty acid ester, two monooleins or isostearic acid monoglyceride.
Preferably, in the ozone vegetable oil emulsifier composition for toothpaste that embodiment of the present invention is provided, emulsifying agent
It is typical but it is non-limiting for tween, it is oleic acid, sorbitan monooleate, methyl glycol fatty acid ester, glycerin monostearate, sweet
Oily monoleate, the combination of oleic acid and sorbitan trioleate, sorbitan monooleate and methyl glycol fatty acid ester
Combination, glycerin monostearate and glycerin mono-fatty acid ester and two monooleins combination or isostearic acid monoglyceride.
Alternatively, in the ozone vegetable oil emulsifier composition for toothpaste that embodiment of the present invention is provided, rubbing agent
Including in Calcium Phosphate, Dibasic Dihydrate, calcium pyrophosphate, precipitated silica, silicate hydrate, three hydration Alpha-aluminas or aluminium hydroxide
It is one or more of.
Preferably, in the ozone vegetable oil emulsifier composition for toothpaste that embodiment of the present invention is provided, rubbing agent
It is typical but non-limiting for Calcium Phosphate, Dibasic Dihydrate, calcium pyrophosphate, precipitated silica, silicate hydrate, three hydration Alpha-aluminas, hydrogen
Aluminum oxide, the combination of Calcium Phosphate, Dibasic Dihydrate and calcium pyrophosphate or the combination of three hydration Alpha-aluminas and aluminium hydroxide.
Alternatively, in the ozone vegetable oil emulsifier composition for toothpaste that embodiment of the present invention is provided, adhesive
Including one in sodium carboxymethylcellulose, hydroxyethyl cellulose, the sour sodium of algae rotation, polyvinyl alcohol, polypropylene phthalein amine or silica
Plant or several.
Preferably, in the ozone vegetable oil emulsifier composition for toothpaste that embodiment of the present invention is provided, adhesive
It is typical but non-limiting for sodium carboxymethylcellulose, hydroxyethyl cellulose, the sour sodium of algae rotation, polyvinyl alcohol, polypropylene phthalein amine, dioxy
The group of SiClx, the combination of sodium carboxymethylcellulose and hydroxyethyl cellulose or the sour sodium of algae rotation and polyvinyl alcohol and polypropylene phthalein amine
Close.
Alternatively, in the ozone vegetable oil emulsifier composition for toothpaste that embodiment of the present invention is provided, foaming agent
Including one in sldium lauryl sulfate, N- laurate sodium sarcosinate, bay phthalein sulfoacetic acid sodium or dioctyl sodium sulphosuccinate
Plant or several.
Preferably, in the ozone vegetable oil emulsifier composition for toothpaste that embodiment of the present invention is provided, foaming agent
It is typical but non-limiting for sldium lauryl sulfate, N- laurate sodium sarcosinate, bay phthalein sulfoacetic acid sodium, dioctyl sodium sulfosuccinates
Sour sodium, the combination of sldium lauryl sulfate and N- laurate sodium sarcosinates or N- laurate sodium sarcosinate and bay phthalein sulfoacetic acid
The combination of sodium.
According to another aspect of the present invention, embodiment of the present invention also provides a kind of ozone trials of emulsion of plant oil for toothpaste
The preparation method of agent composition, comprises the following steps：After ozone vegetable oil, emulsifying agent and water are heated respectively, while stirring
Water and emulsifying agent are added in ozone vegetable oil and is incubated；Rubbing agent, adhesive, foaming agent and essence are added after cooling, is stirred
Mix the ozone vegetable oil emulsifier composition obtained after uniform and cooling for toothpaste.
The preparation method for the ozone vegetable oil emulsifier composition for toothpaste that embodiment of the present invention is provided, which is used, divides
The method for criticizing charging, first heats ozone vegetable oil, emulsifying agent and water respectively, then while stirring that water and emulsifying agent addition is smelly
In oxygen vegetable oil and it is incubated, rubbing agent, adhesive, foaming agent and essence is added after cooling and is stirred, is obtained after cooling
For the ozone vegetable oil emulsifier composition of toothpaste, this method process is simple and easily operated, it is considered to the dissolubility of each component
And thermal sensitivity is different there is provided preferably dissolution system and reaction temperature, it ensure that each component fully participates in reaction, obtain
Obtain steady quality, the ozone vegetable oil emulsifier composition for toothpaste of uniform properties.
Alternatively, the preparation method for the ozone vegetable oil emulsifier composition for toothpaste that embodiment of the present invention is provided
In, heating-up temperature is 65-80 DEG C, and soaking time is 1-2h, and the temperature after cooling is less than 40 DEG C.
Due to considering that the dissolubility and thermal sensitivity of each component are different, therefore the ozone plant added at 65-80 DEG C
Oil, emulsifying agent and water fully can be dissolved and disperse, and form homogeneous system, and other components are added below 40 DEG C and are more beneficial for instead
The progress answered, embodiment of the present invention provides preferably dissolution system and reaction temperature, ensure that each component is fully participated in
Reaction, obtains steady quality, the ozone vegetable oil emulsifier composition for toothpaste of uniform properties.
Alternatively, it is 65 DEG C that heating-up temperature is typical but non-limiting, 66 DEG C, 67 DEG C, 68 DEG C, 69 DEG C, 70 DEG C, 71 DEG C, 72
DEG C, 73 DEG C, 74 DEG C, 75 DEG C, 76 DEG C, 77 DEG C, 78 DEG C, 79 DEG C or 80 DEG C；Soaking time it is typical but it is non-limiting for 1h, 1.5h or
2h；Typical but non-limiting temperature after cooling is 38 DEG C, 37 DEG C, 36 DEG C, 35 DEG C, 32 DEG C or 30 DEG C.
Preferably, the preparation method for the ozone vegetable oil emulsifier composition for toothpaste that embodiment of the present invention is provided
In, after ozone vegetable oil, emulsifying agent and water are heated respectively, water and emulsifying agent are added in ozone vegetable oil and protected while stirring
The step of temperature is specifically included：Ozone vegetable oil, emulsifying agent and water are separately heated to after 70 DEG C, stirring side adds water and emulsifying agent
Enter and mixed in ozone vegetable oil, ozone vegetable oil, emulsifying agent and water is fully dissolved, be incubated 1-2h.
In order to avoid rubbing agent, adhesive, foaming agent and essence are oxidized during the course of the reaction, embodiment of the present invention
There is provided the preparation method for the ozone vegetable oil emulsifier composition of toothpaste in, added after cooling rubbing agent, adhesive,
Foaming agent and essence, stir and are specifically included the step of cooling：It is cooled to after less than 40 DEG C, friction is added while stirring
Agent, adhesive, foaming agent and essence, and continue to be evenly stirred until normal temperature (20-25 DEG C).
Preferably, the preparation side for the ozone vegetable oil emulsifier composition for toothpaste that embodiment of the present invention is provided
Method, comprises the following steps：Ozone vegetable oil, emulsifying agent and water are separately heated to after 70 DEG C, stirring side adds water and emulsifying agent
Enter and mixed in ozone vegetable oil, ozone vegetable oil, emulsifying agent and water is fully dissolved, be incubated 1-2h；Be cooled to 40 DEG C with
After lower, rubbing agent, adhesive, foaming agent and essence are added while stirring, and continues to be evenly stirred until normal temperature (20-25 DEG C), just
Obtain the ozone vegetable oil emulsifier composition for toothpaste.
With reference to specific embodiment and comparative example, the invention will be further described.
Embodiment 1
According to percetage by weight, following components is weighed：Ozone soybean oil 20%, oleic acid 8%, purified water 22%, three hydrations
Alpha-alumina 50%.
Then the ozone vegetable oil emulsifier composition for toothpaste is prepared in accordance with the following steps：By ozone soybean oil, oil
Acid and purified water are separately heated to after 65 DEG C, add oleic acid and purified water mixed in ozone soybean oil while stirring, make
Ozone soybean oil, oleic acid and purified water fully dissolve, and are incubated 1h；It is cooled to after 38 DEG C, three is added while stirring and is hydrated alpha-oxidation
Aluminium, and continue to be evenly stirred until normal temperature, just obtain the ozone vegetable oil emulsifier composition for toothpaste.
Embodiment 2
According to percetage by weight, following components is weighed：Ozone olive oil 40%, sorbitan monooleate 10% is pure
Change water 20%, calcium pyrophosphate 30%.
Then the ozone vegetable oil emulsifier composition for toothpaste is prepared in accordance with the following steps：By ozone olive oil, lose
Water sorbitol monooleate and purified water are separately heated to after 80 DEG C, while stirring by sorbitan monooleate and purified water
Add and mixed in ozone olive oil, ozone olive oil, sorbitan monooleate and purified water is fully dissolved, be incubated
1.5h；It is cooled to after 30 DEG C, calcium pyrophosphate is added while stirring, and continue to be evenly stirred until normal temperature, just obtains for toothpaste
Ozone vegetable oil emulsifier composition.
Embodiment 3
According to percetage by weight, following components is weighed：Ozone corn oil 28%, methyl glycol fatty acid ester 12%, purified water
24%, Calcium Phosphate, Dibasic Dihydrate 32%, sodium carboxymethylcellulose 1%, sldium lauryl sulfate 2%, caryophyllus oil 1%.
Then the ozone vegetable oil emulsifier composition for toothpaste is prepared in accordance with the following steps：By ozone corn oil, third
Diol fatty acid ester and purified water are separately heated to after 70 DEG C, and methyl glycol fatty acid ester and purified water are added into ozone while stirring
Mixed in corn oil, ozone corn oil, methyl glycol fatty acid ester and purified water is fully dissolved, be incubated 1h；It is cooled to 35
After DEG C, Calcium Phosphate, Dibasic Dihydrate, sodium carboxymethylcellulose, sldium lauryl sulfate and caryophyllus oil are added while stirring, and continue stirring
Uniformly to normal temperature, the ozone vegetable oil emulsifier composition for toothpaste is just obtained.
Embodiment 4
According to percetage by weight, following components is weighed：Ozone rapeseed oil 32%, methyl glycol fatty acid ester 9%, purified water
20%, silicate hydrate 35%, hydroxyethyl cellulose 1%, N- laurate sodium sarcosinate 2.5%, orange oil 0.5%.
Preparation method be the same as Example 3, and respective sets are allocated as adaptability addition.
Embodiment 5
According to percetage by weight, following components is weighed：Ozone rapeseed oil 22%, isostearic acid monoglyceride 11%, purifying
Water 23%, precipitated silica 40%, the sour sodium 2% of algae rotation, bay phthalein sulfoacetic acid sodium 2.3%, Rosa Damascana 0.7%.
Preparation method be the same as Example 3, and respective sets are allocated as adaptability addition.
Embodiment 6
According to percetage by weight, following components is weighed：Ozone tea-seed oil 25%, glycerin mono-fatty acid ester 20%, purified water
21%, aluminium hydroxide 30%, polyvinyl alcohol 1.5%, dioctyl sodium sulphosuccinate 2%, cinnamon oil 0.5%.
Preparation method be the same as Example 3, and respective sets are allocated as adaptability addition.
Comparative example 1
According to percetage by weight, following components is weighed：Ozone rapeseed oil 10%, purified water 42%, other components and content
Be the same as Example 3.
Preparation method be the same as Example 3.
Comparative example 2
According to percetage by weight, following components is weighed：Ozone rapeseed oil 45%, purified water 7%, other components and content are same
Embodiment 3.
Preparation method be the same as Example 3.
Comparative example 3
According to percetage by weight, following components is weighed：Methyl glycol fatty acid ester 5%, purified water 31% and contains other components
Measure be the same as Example 3.
Preparation method be the same as Example 3.
Comparative example 4
According to percetage by weight, following components is weighed：Methyl glycol fatty acid ester 25%, purified water 11%, other components and
Content be the same as Example 3.
Preparation method be the same as Example 3.
Comparative example 5
According to percetage by weight, following components is weighed：Purified water 36%, Calcium Phosphate, Dibasic Dihydrate 20% and contains other components
Measure be the same as Example 3.
Preparation method be the same as Example 3.
Comparative example 6
According to percetage by weight, following components is weighed：Purified water 1%, Calcium Phosphate, Dibasic Dihydrate 55%, other components and content
Be the same as Example 3.
Preparation method be the same as Example 3.
Experimental example
In order to further examine provided by the present invention for toothpaste ozone vegetable oil emulsifier composition both effectiveness and
Toxicologic properties, have carried out following experimental study：
1st, both effectiveness experiment
By the ozone vegetable oil emulsifier composition for toothpaste obtained by embodiment 1-6 and comparative example 1-6 by identical
Processing toothpaste is made.
130 volunteers are randomly selected, the age is 16-40 Sui, and average age 23 years old, M-F is 1：1, it is divided into
13 groups.Each group volunteer brushes teeth sooner or later daily, and corresponding use respectively is above-mentioned to be used for toothpaste containing embodiment 1-6 and comparative example 1-6
Ozone vegetable oil emulsifier composition toothpaste, while also setting up reference examples, this group of volunteer brushes teeth sooner or later daily uses one
Plant existing toothpaste.Test period is 14 days.
After use by the way of volunteer's marking evaluation effect, scoring criterion as shown in table 1, counts the average mark of each group
Afterwards, specific scores are as shown in table 2.
The scoring criterion of table 1
| For oral cavity oxygen supply | Sterilizing oral anti-inflammatory | Remove calculus dentalis | |
| Effect is notable | 7-10 | 7-10 | 7-10 |
| Effect is general | 2-6.9 | 2-6.9 | 2-6.9 |
| It is invalid | 0-1.9 | 0-1.9 | 0-1.9 |
The using effect score of table 2
| Group | Source | For oral cavity oxygen supply | Sterilizing oral anti-inflammatory | Remove calculus dentalis |
| 1 | Embodiment 1 | 7.8 | 8.5 | 8.5 |
| 2 | Embodiment 2 | 8.0 | 9.0 | 8.8 |
| 3 | Embodiment 3 | 8.1 | 9.1 | 9.0 |
| 4 | Embodiment 4 | 7.9 | 8.9 | 8.7 |
| 5 | Embodiment 5 | 7.6 | 8.4 | 8.3 |
| 6 | Embodiment 6 | 7.3 | 8.7 | 8.4 |
| 7 | Comparative example 1 | 5.0 | 4.5 | 8.1 |
| 8 | Comparative example 2 | 7.9 | 9.0 | 8.5 |
| 9 | Comparative example 3 | 6.9 | 6.5 | 6.0 |
| 10 | Comparative example 4 | 7.4 | 8.4 | 8.1 |
| 11 | Comparative example 5 | 7.1 | 6.6 | 4.7 |
| 12 | Comparative example 6 | 7.4 | 6.9 | 7.1 |
| 13 | Reference examples | 0 | 6.4 | 4.3 |
The toothpaste that 1-6 groups are used it can be seen from the result of table 2 is oral cavity oxygen supply, sterilizing oral anti-inflammatory and removes tooth
The effect of calculus is substantially better than 7-13 groups, shows ozone vegetable oil, emulsifying agent, rubbing agent and water in inventive formulation and its
Rationally, each component coordinates can produce preferably effect to the scientific formulation of its component.By 1-6 groups and the 7th group and the 8th group of knot
Fruit contrast understands that the proportioning of ozone vegetable oil and water within the specific limits, can provide oxygen for oral cavity, while to sterilizing oral
The effect of anti-inflammatory and removing calculus dentalis is preferable；For the 7th group, i.e., for ozone in the ozone vegetable oil emulsifier composition of toothpaste
The ratio of vegetable oil and water is too low, and oxygen is provided for oral cavity, while poor to oral cavity bactericidal antiphlogistic and the effect for removing calculus dentalis；
For the 8th group, i.e., the ratio for ozone vegetable oil and water in the ozone vegetable oil emulsifier composition of toothpaste is too high, is oral cavity
There is provided oxygen, while more optimize to oral cavity bactericidal antiphlogistic and effect of the effect also not than the 3rd group for removing calculus dentalis, but
The cost of material of ozone vegetable oil is added, and corrosivity easily is produced to tooth, the requirement of actual production is not met.This
Outside, from 1-6 groups and the 9th group and the 10th group of Comparative result, the amount of emulsifying agent is used for the smelly of toothpaste for prepared
The property of oxygen vegetable oil emulsifier composition also has a certain impact, so that the property of the toothpaste containing the emulsifier combination
It is affected.Compared with the 3rd group, emulsifier content is too low in the 9th group, then is easily caused the ozone vegetable oil emulsification for toothpaste
The uniformity and less stable of agent composition, so that the both effectiveness reduction of corresponding toothpaste；It is newborn in the 10th group compared with the 3rd group
The too high levels of agent, the both effectiveness of corresponding toothpaste does not also optimize more, but adds the cost of material of emulsifying agent, no
Meet the requirement of actual production.In addition, from 1-6 groups and the 11st group and the 12nd group of Comparative result, the consumption of rubbing agent
Also effect of the prepared ozone vegetable oil emulsifier composition for toothpaste is influenceed, so that containing the emulsifier combination
The property of toothpaste is also affected.Compared with the 3rd group, the content of rubbing agent is too low in the 11st group, easily causes for toothpaste
The clean-up performance of ozone vegetable oil emulsifier composition is poor, so that the toothpaste containing the emulsifier combination is for calculus dentalis etc.
The elimination effect of foreign matter is poor.Toothpaste can be also influenceed simultaneously to the restraining and sterilizing bacteria effect in oral cavity；Compared with the 3rd group, in the 11st group
The too high levels of rubbing agent, the both effectiveness of corresponding toothpaste does not optimize, but adds the cost of material of rubbing agent, does not meet
The requirement of actual production.
By further detection, the present invention is used in the ozone vegetable oil emulsifier composition of toothpaste, ozonide content
Average value be 13g/L, be conducive to providing suitable oxygen for oral cavity, promote sterilizing oral anti-inflammatory and removing calculus dentalis effect.
In summary, the present invention for toothpaste ozone vegetable oil emulsifier composition scientific formulation rationally, with for
Sterilizing oral anti-inflammatory and the effect of oxygen supply, can effectively remove calculus dentalis, protect the health of one's mouth.
2nd, toxicological experiment
Using the ozone vegetable oil emulsifier composition made from embodiment 1-6 for toothpaste as sample, carry out toxicity and grind
Study carefully, it is specific as follows：
(1) acute oral toxicity test
Tested using a limits, sample given low is 5000mg/kg；Carry out mouse fasting before gavage contamination
Night.Poisoning symptom or Behavioral change are observed after contamination daily, is weighed weekly once.To after be poisoned to death mouse and gavage contamination 14
Its survival mice makees gross anatomy observation.Detection foundation is the Ministry of Public Health《Disinfection technology standard》(version in 2002).
Test mice has no in 14 days in contamination and any poisoning symptom and is poisoned to death；The average weight of male and female mouse has no
It is abnormal.After Germicidal efficacy terminates, gross anatomy inspection is carried out to test mice and also had no abnormal changes.Therefore, the present invention is used for
The ozone vegetable oil emulsifier composition of toothpaste is actual nontoxic to chmice acute Oral toxicity result of the test, has no other toxicity.
(2) multiple Skin Irritation Test
Family's rabbit back backbone both sides dorsal body setae is cut before experiment, unhairing scope is 3cm × 3cm, and surface covered is 2.5cm
×2.5cm.Take 0.5mL sample applications on the side skin of rabbit backbone, opposite side is used as control.Cleaned after smearing 4h with water
Totally.Carry out once daily, continuously coating 14d, other experimental condition all sames.24h observes result and commented after each coating
Point, judge skin irritatin intensity.Detection foundation is the Ministry of Public Health《Disinfection technology standard》(version in 2002).
The present invention is to the multiple skin irritation assay of rabbit for the ozone vegetable oil emulsifier composition of toothpaste
Without obvious stimulation effect, other toxicity are had no.
3 bactericidal properties are tested
Sample is placed in 37 DEG C of insulating boxs 3 months, relative humidity 76% is kept, bactericidal property test, control group is carried out
Do not deal with, the bactericidal action time is 5min.Detection method refers to GB15979-2002.Experimental result is as shown in table 3.
The result of the test of table 3
Result of the test shows that the present invention has the effect of bactericidal antiphlogistic for the ozone vegetable oil emulsifier composition of toothpaste
Really, and meet《Disposable Sanitary Accessory sanitary standard GB15979-2002》Requirement.The present invention is used for toothpaste after testing
Ozone vegetable oil emulsifier composition can to preserve bactericidal effect after 2 years at normal temperatures still constant, with higher stabilization
Property.
Specific embodiment described in this specification is only to spirit explanation for example of the invention.Skill belonging to of the invention
The technical staff in art field can make various modifications or supplement to described specific embodiment or use similar side
Formula is substituted, but without departing from the spiritual of the present invention or surmounts scope defined in appended claims.
Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that without departing substantially from the present invention's
Many other changes and modification can be made in the case of spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (10)
1. a kind of ozone vegetable oil emulsifier composition for toothpaste, it is characterised in that mainly prepared by following components：
Ozone vegetable oil 20-40%, emulsifying agent 8-20%, water 20-40%, rubbing agent 30-50%.
2. the ozone vegetable oil emulsifier composition according to claim 1 for toothpaste, it is characterised in that according to weight
Percentage meter, is mainly prepared by following components：Ozone vegetable oil 21-39%, emulsifying agent 9-19%, water 21-38%, friction
Agent 31-49%.
3. the ozone vegetable oil emulsifier composition according to claim 2 for toothpaste, it is characterised in that according to weight
Percentage meter, is mainly prepared by following components：Ozone vegetable oil 25-35%, emulsifying agent 10-18%, water 25-35%, rub
Liniment 35-45%.
4. the ozone vegetable oil emulsifier composition for toothpaste according to claim any one of 1-3, it is characterised in that
According to percent by weight, the component of the ozone vegetable oil emulsifier composition for toothpaste also includes adhesive 1-2%,
Foaming agent 2-8%, essence 0.5-2%.
5. the ozone vegetable oil emulsifier composition for toothpaste according to claim any one of 1-3, it is characterised in that
The ozone vegetable oil includes ozone soybean oil, ozone olive oil, ozone rapeseed oil, ozone corn oil, ozone tea-seed oil or smelly
One or more in oxygen sunflower oil.
6. the ozone vegetable oil emulsifier composition for toothpaste according to claim any one of 1-3, it is characterised in that
The emulsifying agent include tween, oleic acid, sorbitan trioleate, sorbitan monooleate, methyl glycol fatty acid ester,
One or more in glycerin monostearate, glycerin mono-fatty acid ester, two monooleins or isostearic acid monoglyceride；
The rubbing agent includes Calcium Phosphate, Dibasic Dihydrate, calcium pyrophosphate, precipitated silica, silicate hydrate, three hydration Alpha-aluminas
Or the one or more in aluminium hydroxide.
7. the ozone vegetable oil emulsifier composition according to claim 4 for toothpaste, it is characterised in that the gluing
Agent is included in sodium carboxymethylcellulose, hydroxyethyl cellulose, the sour sodium of algae rotation, polyvinyl alcohol, polypropylene phthalein amine or silica
It is one or more of.
8. the ozone vegetable oil emulsifier composition according to claim 4 for toothpaste, it is characterised in that the foaming
Agent is included in sldium lauryl sulfate, N- laurate sodium sarcosinate, bay phthalein sulfoacetic acid sodium or dioctyl sodium sulphosuccinate
It is one or more of.
9. it is used for the preparation method of the ozone vegetable oil emulsifier composition of toothpaste described in a kind of claim 4, it is characterised in that
Comprise the following steps：After ozone vegetable oil, emulsifying agent and water are heated respectively, water and emulsifying agent are added into ozone while stirring and planted
Thing oil in and be incubated；Rubbing agent, adhesive, foaming agent and essence are added after cooling, stirs and is used for after cooling
The ozone vegetable oil emulsifier composition of toothpaste.
10. preparation method according to claim 9, it is characterised in that heating-up temperature is 65-80 DEG C, and soaking time is 1-
2h, the temperature after cooling is less than 40 DEG C.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107714580A (en) * | 2017-10-27 | 2018-02-23 | 陈政秀 | A kind of Chinese medicine super oxygen toothpaste |
| CN107802579A (en) * | 2017-12-06 | 2018-03-16 | 湖南省雅迭香科技有限公司 | Rosemary toothpaste and preparation method thereof |
| CN113633583A (en) * | 2021-09-08 | 2021-11-12 | 广州星际悦动股份有限公司 | Oral care compositions |
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|---|---|---|---|---|
| DE19932570A1 (en) * | 1999-07-13 | 2001-01-18 | Gerhard Steidl | Dental antimicrobial preparation comprises olive and/or castor oil enriched with ozone, releases oxygen to control anerobic bacteria e.g. those causing paradontosis |
| IT1369128B1 (en) * | 2006-03-15 | 2010-01-11 | Multiossigen S R L | |
| CN102178632A (en) * | 2011-05-06 | 2011-09-14 | 石平安 | Application of ozonized oil to preparation of raw materials of medical health-care products |
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2017
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|---|---|---|---|---|
| DE19932570A1 (en) * | 1999-07-13 | 2001-01-18 | Gerhard Steidl | Dental antimicrobial preparation comprises olive and/or castor oil enriched with ozone, releases oxygen to control anerobic bacteria e.g. those causing paradontosis |
| IT1369128B1 (en) * | 2006-03-15 | 2010-01-11 | Multiossigen S R L | |
| CN102178632A (en) * | 2011-05-06 | 2011-09-14 | 石平安 | Application of ozonized oil to preparation of raw materials of medical health-care products |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107714580A (en) * | 2017-10-27 | 2018-02-23 | 陈政秀 | A kind of Chinese medicine super oxygen toothpaste |
| CN107802579A (en) * | 2017-12-06 | 2018-03-16 | 湖南省雅迭香科技有限公司 | Rosemary toothpaste and preparation method thereof |
| CN113633583A (en) * | 2021-09-08 | 2021-11-12 | 广州星际悦动股份有限公司 | Oral care compositions |
| CN113633583B (en) * | 2021-09-08 | 2024-03-08 | 广州星际悦动股份有限公司 | Oral care compositions |
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