CN107007874A - A kind of silicon substrate wound repair aqueous gel and preparation method thereof - Google Patents
A kind of silicon substrate wound repair aqueous gel and preparation method thereof Download PDFInfo
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- CN107007874A CN107007874A CN201710166183.8A CN201710166183A CN107007874A CN 107007874 A CN107007874 A CN 107007874A CN 201710166183 A CN201710166183 A CN 201710166183A CN 107007874 A CN107007874 A CN 107007874A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0038—Gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/21—Acids
- A61L2300/214—Amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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Abstract
A kind of silicon substrate wound repair aqueous gel, is formulated as follows：Carbomer：0.8g~1.5g；Glycerine 40ml~60mL；Propane diols：45ml~70mL；Gelatin：0.3g~1.2g；Bioactivity glass：6g~16g；Pearl powder：0.6g~1.4g.The present invention adds calcium carbonate and various amino acid, the pearl meal component of nutrition can be supplied for surface of a wound local organization on the basis of with silicon substrate wound repair material, i.e. bioactivity glass for main repair materials；Aqueous gel formulation is made in the case where being added without water simultaneously, so as to avoid silicon substrate wound repair material from meeting water denaturation, shield wound is smeared with its formulation characteristic, wound moist can be kept, hypoxemia, slightly sour environment, accelerating wound healing is created, and sepage, autolyzed debridement can be absorbed.
Description
Technical field
The invention belongs to soft tissue repair technical field, more particularly to a kind of silicon substrate wound repair aqueous gel and its preparation
Method.
Background technology
With developing rapidly for modern medicine, particularly molecular biology, novel trauma is repaired dressing and continued to bring out, these
Repair dressing can not only flap coverage, and with promotion organization repair function, provides growing environment for cambium, acceleration
Wound healing, reduce scar, prevent germ contamination, and with biodegradable.
Silicon substrate wound repair material (also referred to as bioactivity glass) main component is silica, calcium oxide, five oxidations
Two phosphorus, sodium oxide molybdena etc., with unique surface-active, can be repaired to body tissue, substituted and be regenerated.Silicon substrate wound repair
Material is dissolved in after body fluid, forms the negatively charged Si-OH in surface, hydrogen bond and ion amine key are passed through with different types of protein
(-Si-O-H3N+- highdensity protein adsorption, silica sol layer and the carbonic acid hydroxyl that high surface area is formed on its surface) are combined to form
Base apatite (Ca10(PO4,CO3)6(OH)2, hydroxyl-carbonate-apatite, HCA) layer, HCA layers of fixed cell and
Responded outside albumen, active cell, promote cell to secrete and breed, accelerate the healing of the surface of a wound.In addition, silicon substrate wound repair material energy
Calcium, sodium, phosphonium ion are produced with tissue fluid to exchange, causes local pH value to improve, and reduce bacterium infection.
Publication number CN 1569246A patents disclose with silicon substrate wound repair material powder directly act on soft tissue burst it is straight
Connect and be coated at wound, or powder spray is overlying on by common medical compressed gas atomization jetting device by the surface of wound, promote
Wound healing.The inconvenience of this method Clinical practice, covers uneven and big to surface of a wound excitant in the surface of a wound.Also have been reported that, by silicon substrate
Wound repair material and medicinal vaseline, light mineral oil etc. are mixed and made into ointment as carrier and used, but debridement is difficult, easily to wound
Cause secondary injury in face.
The content of the invention
The purpose of the present invention is：A kind of silicon substrate wound repair material excitant, increase repair materials of mitigating is provided to support into
The formula divided, while silicon substrate wound repair aqueous gel is made in the case where being added without water to avoid silicon substrate wound repair material
Water denaturation is met, with excitant is small, allergy rate is low, stretchability is good, be easy to debridement and dressing, the convenient advantage of Clinical practice.
The technical scheme is that：A kind of silicon substrate wound repair aqueous gel, it includes：Carbomer, glycerine, the third two
Alcohol, gelatin and bioactivity glass.The program is by excipients of carbomer and viscous using bioactivity glass as main active
Attached dose, using glycerine, propane diols as solvent, using gelatin as setting agent, constitute the medical gel with tissue wound repair function.
Further, silicon substrate wound repair aqueous gel of the invention also includes pearl powder：Pearl powder calcium carbonate and each
Amino acid is planted, the collagenocyte in human body can be promoted to grow, so as to promote wound healing, while pearl powder may also participate in blood coagulation
Process, accelerates blood stove albumen to separate out, and shortens the clotting time, and with relatively more significant antiinflammation, prevents wound from further disliking
Change.In the silicon substrate wound repair aqueous gel of the present invention, silicon substrate wound repair material is dissolved in body fluid, and HCA is formed on surface of a wound surface
Responded outside layer, HCA layers of active cell, promote cell to secrete and breed；Pearl powder calcium carbonate and various amino acid, external application can be
Surface of a wound local organization supplies nutrition, and the two compatibility plays synergy, accelerates wound healing.Pearl powder is also silicon substrate of the present invention
The main component of wound repair aqueous gel.
Further, above-mentioned carbomer is one kind in carbomer 934, Acritamer 940 and Carbopol 941, in system
It is excipients and adhesive in agent, makes to form transparent gel-form, to make gel stick to the tissue surface of a wound when in use.
Further, above-mentioned bioactivity glass is 45S5 glass powders or 45S glass powders, and particle size range is in 150nm
Between~800nm, bioactivity glass is one of the silicon substrate induction wound repair material in gel, wound repair active component.
Further, the propane diols that the present invention is used is 1,2-PD.
Further, above-mentioned pearl powder is fresh water pearl powder or sea water pearls powder.
Further, above-mentioned fresh water pearl powder or sea water pearls powder are ultra-fine pearl of the particle diameter below 15 microns
The Nano pearl powder of powder or particle diameter below 100 nanometers.
Also further, the formula composition that each composition is constituted in silicon substrate wound repair aqueous gel of the present invention is as follows：Card ripple
Nurse：0.8g~1.5g；Glycerine 40ml~60mL；Propane diols：45ml~70mL；Gelatin：0.3g~1.2g；Bioactivity glass：
6g~16g；Pearl powder：0.6g~1.4g.
Present invention additionally comprises the preparation method of above-mentioned silicon substrate wound repair aqueous gel, comprise the following steps：
A) glycerine 40ml~60mL and 1,2-PD 45ml~70mL are measured in sterile chamber, it is fully miscible；Weigh
Carbomer 0.8g~1.5g, is uniformly sprinkling upon the solvent surface of the miscible formation of glycerine, propane diols, and low-speed electronic stirring 10min~
30min, 70 DEG C~95 DEG C water-baths stand 12h~24h, are fully swelled that to form jelly standby；
B) it is standby that bioactivity glass 6g~16g, gelatin 0.3g~1.2g, pearl powder 0.6g~1.4g are weighed respectively；
C) by the jelly prepared by step a) under 70 DEG C~95 DEG C homogenizer high speed shears of water-bath, add thereto successively
Enter gelatin, bioactivity glass, fully stir evenly, reduction bath temperature keeps adding under homogenizer high speed shear to 55 DEG C~65 DEG C
Enter pearl powder, fully stir evenly, naturally cool to room temperature, stand degassing, silicon substrate wound repair aqueous gel is made.
Compared with prior art, advantage is as follows by the present invention：
1) aqueous gel formulation (silicon substrate is made silicon substrate wound repair aqueous gel of the invention in the case where being added without water
Wound repair material is met water and is denatured at once, and the formula and technique for being added without water are in order to avoid silicon substrate wound repair material modification),
Because gel preparations have the characteristics of excitant is small, allergy rate is low, and stretchability is good, it is easy to debridement and dressing, Clinical practice side
Just.
2) silicon substrate wound repair aqueous gel of the invention is easily and the tissue surface of a wound is miscible, the bioactivity glass in gel
Glass, the release of pearl powder isoreactivity composition are fast, play wound repair effect rapider.
3) in silicon substrate wound repair aqueous gel of the invention, silicon substrate wound repair material is dissolved in body fluid, on surface of a wound surface
Formed outside HCA layers, HCA layers of active cell and responded, promote cell to secrete and breed；Pearl powder calcium carbonate and various amino acid,
External application can supply nutrition for surface of a wound local organization, and the two compatibility plays synergy, accelerates wound healing.
4) silicon substrate wound repair aqueous gel of the invention adds gelatin, has good compatibility with biological tissue, has
There is the performance for promoting cell adhesion and growth, so that strengthen wound repair effect, and with activated macrophage and hemostatic function.
Aqueous gel formulation is made in the case where not adding water by the present invention, and shield wound is smeared with its formulation characteristic, in silicon substrate wound
On the basis of face repair materials are main repair materials, add calcium carbonate and various amino acid, can be the surface of a wound and persistently provide
The pearl meal component of nutrient, can keep wound moist, create hypoxemia, slightly sour environment, accelerating wound healing, and can absorb and ooze
Liquid, autolyzed debridement.
Embodiment
Embodiment 1：Formula and preparation method
1.1 formula
A kind of silicon substrate wound repair aqueous gel, its composition of raw materials is as follows:
Wherein, carbomer is one kind in carbomer 934, Acritamer 940 and Carbopol 941；Bioactivity glass
For 45S5 glass powders or 45S glass powders, particle size range is between 150nm~800nm；Propane diols is 1,2-PD；It is precious
Pearl powder is fresh water pearl powder or sea water pearls powder, and superfine pearl powder or particle diameter of its particle diameter below 15 microns exist
Less than 100 nanometers of Nano pearl powder.
1.2 preparation method
The preparation method of silicon substrate wound repair aqueous gel of the present invention is：
A) glycerine 40ml~60mL and 1,2-PD 45ml~70mL are measured in sterile chamber, it is fully miscible；Weigh
Carbomer 0.8g~1.5g, is uniformly sprinkling upon the solvent surface of the miscible formation of glycerine, propane diols, and low-speed electronic stirring 10min~
30min, 70 DEG C~95 DEG C water-baths stand 12h~24h, are fully swelled that to form jelly standby；
B) it is standby that bioactivity glass 6g~16g, gelatin 0.3g~1.2g, pearl powder 0.6g~1.4g are weighed respectively；
C) by the jelly prepared by step a) under 70 DEG C~95 DEG C homogenizer high speed shears of water-bath, add thereto successively
Enter gelatin, bioactivity glass, fully stir evenly, reduction bath temperature keeps adding under homogenizer high speed shear to 55 DEG C~65 DEG C
Enter pearl powder, fully stir evenly, naturally cool to room temperature, stand degassing, silicon substrate wound repair aqueous gel is made.
Embodiment 2：Wound healing is tested
2.1 material
SD rats 20,200~220g of body weight is provided by Changsha Tian Qin Bioisystech Co., Ltd；The silicon substrate surface of a wound is repaiied
Rehydration gel (self-control)；Zinc sulfadiazine paste (pharmaceutical Co. Ltd of township in the gold space biotechnology of Shanghai)；Light microscope
(Shanghai optical instrument factory).
2.2 method
SD rats are randomly divided into 2 groups：Zinc sulfadiazine paste group 16, silicon substrate wound repair aqueous gel group 16.With
15% chloraldurate (2ml/kg) intraperitoneal injection of anesthesia rat, rat is fixed on operating desk in prone position after success.Reject rat
Back chaeta, clear water is rinsed, and 75% alcohol disinfecting overleaf makees diameter 3cm full thickness dermal wounds, locally uses dioxygen
Water, chlorohexidene, normal saline flushing, 75% alcohol disinfecting of surface of a wound surrounding skin, sterile gauze are dried.1st week, change daily
Medicine, dressing every other day later to 20d or so.
2.3 observation index
1) ordinary circumstance
The observation rat surface of a wound whether there is situations such as infection, suppuration and granulation tissue grow daily.
2) Wound healing rate
The surface of a wound is attached at grid transparent plastic film, the surface of a wound is scanned after the surface of a wound respectively at preparing, after causing injury
The surface of a wound area that 1d is measured is initial area, calculates Wound healing rate percentage.Formula：Wound healing rate=[(primary face
Product-revolution mark)/initial area] × 100%.
3) HE dyeing observation
Every group takes 4 rats as pathologic group.Respectively at preparing after the surface of a wound 3d, 6d, 12d, 20d in pathologic group rat
Surface of a wound edge cutting tissue block (0.5 × 0.5 × 0.5cm3) send pathological section, Microscopic observation section.
2.4 result
1) ordinary circumstance compares
The surface of a wound prepares 3d, and two groups of surface of a wound have oozing of blood, without substantially fresh granulation tissue generation, has no that epithelial tissue is long
Enter.The silicon substrate few partial exfoliation of the visible slough of wound repair aqueous gel group and a small amount of secretion, zinc sulfadiazine paste
The visible more secretion of group.
The surface of a wound prepares 6d, and the silicon substrate wound repair aqueous gel group surface of a wound has a small amount of oozing of blood, sepage, and the surface of a wound is cleaner, applies
Material is dispersed in distribution with the surface of a wound without adhesion, surface of a wound edge and the newborn epithelial tissue of internal and visible a small amount of white；Sulfadiazine zinc is soft
The cream group surface of a wound has oozing of blood, and there being the surface of a wound with dressing during dressing has no newborn epithelial tissue inside adhesion phenomenon, the surface of a wound, edge is visible to be had
A small amount of epithelium is grown into.
The surface of a wound prepares 12d, reduces in silicon substrate wound repair aqueous gel group wound week, the surface of a wound is relatively dried, bad without obvious oozing of blood
Dead tissue has come off, and has more newborn epidermal tissue to be grown into from edge, and newborn epithelial tissue is distributed in island inside the surface of a wound, edge
It can be seen that epithelium tissue member is formed a scab, part is healed；The zinc sulfadiazine paste group surface of a wound still has a small amount of sepage without obvious oozing of blood, bad
Dead tissue is come off substantially, and surface of a wound edge is visible to be dispersed in newborn epithelial tissue and grow into, visible a small amount of newborn epithelial tissue inside planing surface.
And thering is incrustation to be formed, granulation tissue is fresh.
The surface of a wound prepares 20d, and the silicon substrate wound repair aqueous gel group surface of a wound is dried, and all covers in newborn white substantially
Skin tissue, but it is relatively thin, and surface is formed without incrustation, close to healing completely；The zinc sulfadiazine paste group surface of a wound is shoaled, and nothing is substantially oozed
Blood, sepage, have more newborn epithelial tissue to be grown into from surface of a wound edge, but the surface of a wound is not completely covered, and surface of a wound incrustation phenomenon is obvious.
2) Wound healing rate compares
Present invention group and zinc sulfadiazine paste group are more as shown in table 1 in the Wound healing rate of different time：Surface of a wound system
Standby 3d, 6d, two groups of healing rates compare, P ＞ 0.05, no significant difference.When 12d, 20d, silicon substrate wound repair aqueous gel group
Healing rate is obviously higher than zinc sulfadiazine paste group, P ＜ 0.05.
The comparison (%) of the two groups of Wound healing rates of different times of table 1
3) pathology section examination
The surface of a wound prepares 3d, and the visible downright bad layer in two groups of surface of a wound surfaces is made up of cell fragment, exudate and bacterium etc..
Cell infiltration below downright bad layer, blood vessel dilatation is congested, bleeding, is oozed out with substantial amounts of liquid.
The surface of a wound prepares 6d, the visible abundant granulation tissue of silicon substrate wound repair aqueous gel group and more inflammatory cell, wound
Face edge has thicker newborn epidermis to be divided a word with a hyphen at the end of a line growth to the surface of a wound；The visible bleeding of zinc sulfadiazine paste group, inflammatory cell and granulation tissue
It is less, there is newborn epidermis.
The surface of a wound prepares 12d, and silicon substrate wound repair aqueous gel group inflammatory cell quantity is reduced, fibroblast quantity and new
Raw epidermis increases, the most of surface of a wound of covering；Zinc sulfadiazine paste group granulation tissue and inflammatory cell start to decorporate, collagen tissue shape
Into, newborn epidermis increases, but not as good as silicon substrate wound repair aqueous gel group.
The surface of a wound prepares 20d, and silicon substrate wound repair aqueous gel group inflammatory cell is further reduced, and collagen tissue arrangement is whole
Together, newborn epidermis flap coverage；The visible a small amount of newborn capillary of zinc sulfadiazine paste group, collagen tissue increases, newborn
The most of surface of a wound of epidermis covering.
In summary, there is the silicon substrate wound repair aqueous gel in the present invention program good quickening wound healing to make
With, be it is a kind of effectively, safety, degradable biological wound repair medical gel.
It is described above, it is only the optimal embodiment of the present invention, but protection scope of the present invention is not limited thereto,
Any one skilled in the art the invention discloses technical scope in, the change or replacement that can be readily occurred in,
It should all be included within the scope of the present invention.
Claims (10)
1. a kind of silicon substrate wound repair aqueous gel, it is characterised in that it includes：Carbomer, glycerine, propane diols, gelatin and life
Thing activity glass.
2. a kind of silicon substrate wound repair aqueous gel as claimed in claim 1, it is characterised in that it also includes pearl powder.
3. a kind of silicon substrate wound repair aqueous gel as claimed in claim 2, it is characterised in that the carbomer is selected from card
One kind in ripple nurse 934, Acritamer 940 and Carbopol 941.
4. a kind of silicon substrate wound repair aqueous gel as claimed in claim 2, it is characterised in that the bioactivity glass is
45S5 glass powders or 45S glass powders.
5. a kind of silicon substrate wound repair aqueous gel as claimed in claim 4, it is characterised in that the bioactivity glass
Particle size range is between 150nm~800nm.
6. a kind of silicon substrate wound repair aqueous gel as claimed in claim 2, it is characterised in that the propane diols is 1,2- third
Glycol.
7. a kind of silicon substrate wound repair aqueous gel as claimed in claim 2, it is characterised in that the pearl powder is that fresh water is precious
Pearl powder or sea water pearls powder.
8. a kind of silicon substrate wound repair aqueous gel as claimed in claim 7, the pearl powder is particle diameter at 15 microns
Nano pearl powder of the following superfine pearl powder or particle diameter below 100 nanometers.
9. a kind of silicon substrate wound repair aqueous gel as claimed in claim 2, it is characterised in that what wherein each composition was constituted matches somebody with somebody
Fang Zucheng is as follows：
Carbomer：0.8g~1.5g；Glycerine 40ml~60mL；Propane diols：45ml~70mL；Gelatin：0.3g~1.2g；Biology is living
Property glass：6g~16g；Pearl powder：0.6g~1.4g.
10. a kind of preparation method of the silicon substrate wound repair aqueous gel in 2-9 such as claim as described in any claim, bag
Include following steps：
A) glycerine 40ml~60mL and 1,2-PD 45ml~70mL are measured in sterile chamber, it is fully miscible；Weigh card ripple
Nurse 0.8g~1.5g, is uniformly sprinkling upon the solvent surface of the miscible formation of glycerine, propane diols, and low-speed electronic stirs 10min~30min,
70 DEG C~95 DEG C water-baths stand 12h~24h, are fully swelled that to form jelly standby；
B) it is standby that bioactivity glass 6g~16g, gelatin 0.3g~1.2g, pearl powder 0.6g~1.4g are weighed respectively；
C) jelly prepared by step a) is added bright thereto successively under 70 DEG C~95 DEG C homogenizer high speed shears of water-bath
Glue, bioactivity glass, are fully stirred evenly, and reduction bath temperature keeps adding treasure under homogenizer high speed shear to 55 DEG C~65 DEG C
Pearl powder, is fully stirred evenly, and naturally cools to room temperature, stands degassing, silicon substrate wound repair aqueous gel is made.
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| CN107715168A (en) * | 2017-10-18 | 2018-02-23 | 张家港蓝智生物科技有限公司 | A kind of functions of stanching and promoting healing uterine neck wound repair anhydrous gel of the microballoon containing bio-vitric |
| CN108210991A (en) * | 2018-01-16 | 2018-06-29 | 宜春学院 | A kind of silicon substrate induced activity liquid dressing and preparation method thereof |
| CN110038154A (en) * | 2018-01-15 | 2019-07-23 | 张家港蓝智生物科技有限公司 | Promote the dressing of wound healing and its preparation method applied to functional sponge |
| CN110638836A (en) * | 2019-08-30 | 2020-01-03 | 广东海洋大学 | Application of water-soluble pearl powder in promoting wound healing |
| CN112843322A (en) * | 2021-01-11 | 2021-05-28 | 苏州汇涵医用科技发展有限公司 | Preparation method of black bioactive ceramic dressing |
| CN114129765A (en) * | 2021-11-29 | 2022-03-04 | 张君华 | Hemostatic material and preparation method and application thereof |
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| CN110638836A (en) * | 2019-08-30 | 2020-01-03 | 广东海洋大学 | Application of water-soluble pearl powder in promoting wound healing |
| CN112843322A (en) * | 2021-01-11 | 2021-05-28 | 苏州汇涵医用科技发展有限公司 | Preparation method of black bioactive ceramic dressing |
| CN114129765A (en) * | 2021-11-29 | 2022-03-04 | 张君华 | Hemostatic material and preparation method and application thereof |
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Application publication date: 20170804 |