CN107007665A - A kind of outer bath anaesthetic of relieving mental strain and helping sleep and preparation method thereof - Google Patents

A kind of outer bath anaesthetic of relieving mental strain and helping sleep and preparation method thereof Download PDF

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CN107007665A
CN107007665A CN201710250741.9A CN201710250741A CN107007665A CN 107007665 A CN107007665 A CN 107007665A CN 201710250741 A CN201710250741 A CN 201710250741A CN 107007665 A CN107007665 A CN 107007665A
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anaesthetic
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奥乌力吉
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Abstract

The present invention relates to a kind of medicine and its preparation method, i.e., the outer bath anaesthetic of a kind of relieving mental strain and helping sleep and preparation method thereof is characterized in：The outer bath anaesthetic of the relieving mental strain and helping sleep includes following bulk drug by weight：10-25 parts of fructus choerospondiatis, 10-25 parts of spina date seed, 10-25 parts of wilsonii, 0.5-1 part of Jasmine.Preparation method：Take bulk drug to be soaked in water by above-mentioned parts by weight, amount of water is 15-25 times of bulk drug gross weight, is first fried open liquid medicine with big fire, then decocted 30 minutes with small fire, filtered, dried, it is standby.Beneficial effect is：Medicine of the present invention has muscle of releiving, the effect of adjusting mood, relieving mental strain and helping sleep, and the property of medicine relaxes, compatibility science has no toxic side effect, prepare simple, it is with low cost, it is easy to use, bring Gospel to insomniac, dizzy, eyesight temporary fuzzy, failure of memory, lassitude that people are produced due to insomnia can effectively be eliminated, think deeply the symptoms such as difficulty, moreover it is possible to be effectively improved sleep, alleviate life, operating pressure.

Description

A kind of outer bath anaesthetic of relieving mental strain and helping sleep and preparation method thereof
Technical field
The present invention relates to a kind of medicine and its preparation method, i.e., the outer bath anaesthetic of a kind of relieving mental strain and helping sleep and preparation method thereof.
Background technology
Insomnia, with regard to its form of expression, can have difficulty falling asleep, sleep unreal (awakening excessive, how long), table is shallow (lacks for sleep Sound sleep), early awakening and sleep insufficiency etc., wherein with difficulty falling asleep, easily waking up and early awakening is the most common.Therefore someone is also referred to as " sleep insomnia ", " sleep continuity insomnia " and " dysphylaxia ".
At present, with scientific and technological progress and the development of society, people's rhythm of life is accelerated, operating pressure is larger, and spirit is often In high-pressure state, thus, have a sleepless night into the common disease of modern, though being not belonging to disease of being critically ill, often sleep is not Foot, sleep quality is not good, has had a strong impact on work, the living and studying of people, and the human body often having a sleepless night is in long-term pain In hardship, and medicine formation is relied on, and long-term taking tranquilizing and allaying excitement class Western medicine can produce drowsiness, the lassitude even pair such as habituation Effect, it is in recent years, preferred as Most patients according to theory of traditional Chinese medical science diagnosis and treatment treatment insomnia card, but Chinese medicine is generally soup Agent, pill, powder, even if being formed into capsule, its flavour of a drug is dense, it is difficult to swallow, and prevents numerous patients from adhering to medication, causes Insomnia is repeatedly, it is difficult to cure.
Treatment of the Mongolian medicine to insomnia has the medicinal bath therapy that rich experience, particularly Mongolian medicine commonly use, and can pass through skin Human body is acted on, mitigates the pain of patient.Because outer bath is not by interior internal organs, toxic side effect is greatly reduced, thus can make for a long time With.But, due to lacking in-depth study, many medicated bath prescriptions are only spread in the form of secret recipe among the people, it is impossible to widely should With, or even it is a large amount of lost.Minority charges to the prescription of ancient books and records, and its is of the remote past, and technique is single, and therapeutic action is by certain office Limit, urgent need is improved with modern means of science and technology.
The content of the invention
The purpose of the present invention is on the basis of arrangement anaesthetic traditional herbal medicine is collected, with Mongolian medicine's theory to instruct, to use for reference now Generation technique means, develop and obtain one kind and releive muscle, adjust mood, outer bath anaesthetic of relieving mental strain and helping sleep and preparation method thereof.
Above-mentioned technology is realized by following technical scheme：Outer bath anaesthetic and its preparation side of a kind of relieving mental strain and helping sleep are provided Method, is characterized in：The outer bath anaesthetic of the relieving mental strain and helping sleep includes following bulk drug by weight：10-25 parts of fructus choerospondiatis, spina date seed 10-25 parts, 10-25 parts of wilsonii, 0.5-1 part of Jasmine.
Described raw material medicaments in part by weight includes：18 parts of fructus choerospondiatis, 18 parts of spina date seed, 18 parts of wilsonii, 0.3 part of Jasmine.
5-8 parts of Fructus Dipsaci, 3-5 parts of fushen, 3-5 parts of the tuber of dwarf lilyturf, lily 2-3 are added in described bulk drug by weight Part.
Keel 1-2,1-2 parts of gypsum, 0.5-1 part of red Bo are added in described bulk drug by weight.
The preparation method of described bulk drug, it is characterised in that：Take bulk drug to be soaked in water by above-mentioned parts by weight, add water Measure as 15-25 times of bulk drug gross weight, be first fried open liquid medicine with big fire, then decocted 30 minutes with small fire, filtered, dried, it is standby With.
The preparation method of described bulk drug, it is characterised in that：Above-mentioned other originals in addition to Jasmine are taken by weight Expect medicine, add 80% ethanol solution of 10-20 times of amounts of bulk drug gross weight, be heated to reflux 15 minutes, filter, filtrate is evaporated, taken Above-mentioned parts by weight Jasmine crushed 60 mesh sieves, and being evaporated thing with filtrate is well mixed, plus ethyl acetate makes dissolving, adds acetic acid second Ester amount was to submerge crude drug, and beyond medicinal material surface, 3-5cm is limited, ultrasonication 30min, filtered, and dried, standby.
The preparation method of the bulk drug, it is characterised in that：Above-mentioned raw materials medicine is taken by weight, is put into cryogenic vacuum expanded In machine, 0.5-0.6MPa is pressurized to, temperature control is below 65 DEG C, and decompression is produced, and is placed in decocting medicine pot, plus bulk drug gross weight 15-25 times of the milk or goat milk of amount, will first be fried open with high heat, then with being cooked by slow fire 30 minutes, filter, obtain filtrate, dry, It is standby.
The beneficial effects of the invention are as follows：Medicine of the present invention has muscle of releiving, the effect of adjusting mood, relieving mental strain and helping sleep, and The property of medicine is relaxed, and compatibility science has no toxic side effect, and prepares simply, with low cost, easy to use, and Gospel is brought to insomniac, Dizzy, eyesight temporary fuzzy, failure of memory, lassitude that people are produced due to insomnia can be effectively eliminated, instead Should be blunt, the symptom such as thinking difficulty, moreover it is possible to be effectively improved sleep, alleviate life, operating pressure.
Embodiment
The first embodiment, takes following bulk drug by weight：10-25 parts of fructus choerospondiatis, 10-25 parts of spina date seed, wilsonii 10-25 parts, 0.5-1 part of Jasmine.It is preferred that 18 parts of fructus choerospondiatis, 18 parts of spina date seed, 18 parts of wilsonii, 0.3 part of Jasmine.
The method of preparation and use of described bulk drug：25-35g of bulk drug is taken by above-mentioned parts by weight, first with gauze by medicine Thing is wrapped, and is soaked 20-30 minutes in pot, water typically can be controlled in 2000 milliliters or so, is first fried open liquid medicine with big fire, then Decocted 30 minutes with small fire.Liquid medicine is poured into bathtub or bathtub after cooked, adding can start to steep dipping after appropriate hot water. According to state of an illness weight, it can take the circumstances into consideration to be added and subtracted.
Bulk drug brief introduction：
Fructus choerospondiatis is Anacardiaceae plant Spondias axillaris Choerospondiasaxillaris (Roxb.) BurttetHill drying and ripening Fruit.Mongolian name pearl is as husky such as very-Chinese herbaceous peony, alias：Five fruits, mountain jujube, dracontomelon duperreanum, mountain jujubes, sweet, acid are mild-natured, imitate it is greasy, again, Soft, function is with curing mainly：Clear away heart-fire heat, cardiac stimulant.Heart heat is cured mainly, palpitaition, heart shouting pain is demented, faints, and the heart is conspicuous according to the disease such as heart failure.Fructus choerospondiatis In contain sugar, amino acid, tannin, sterol, flavonoids and phenols component.
Spina date seed, alias jujube kernel, mountain jujube, spina date seed, the dry mature seed of rhamnaceae plant wild jujube.Spina date seed is containing biology Alkali：Spina date seed alkali（sanjoinine）A, B, D, E, F, G1, G2, Ia, Ib, K, wherein alkali A are exactly frangufoline（frangu- foline）, alkali E is exactly Nuciferine, and alkali Ia is exactly miltanthin（nornu-ciferine）, alkali Ib is exactly norisocorydine （norisocorydine）, alkali K is exactly the coclaurine of dextrorotation（coclaurine）, N- methyl asimilobines（N- methylasimilo-bine）, sour Lee's alkali（zizyphusine）, 5- hydroxyl -6- methoxyl groups remove first aporphine（Caaver-ine, 5-hydroxy-6-methoxynoraporphine）, amphibin D（amphibine）D.Also cyclic peptide containing spina date seed （sanjoinenine）.Also contain triterpenes：Betulic acid（betulinic acid）, betulin（betulin）, ceanothic acid （ceanothic acid）, alphitolic acid（alphitolic acid）, jujuboside（jujuboside）A, B, and carrot Glucoside（daucosterol）, flavonoids is contained again.Nature and flavor：Sweet, acid, puts down.Enter liver, courage, the heart channel of Hang-Shaoyin.Major function：Tonifying liver, calming heart is held back Sweat, promotes the production of body fluid.Spina date seed is calming the nerves, there is its original opinion in insomnia field, and evident in efficacy, " is slept in east by doctor patient's laudatory title Really ".
Wilsonii, is drying, root and rhizome or the stem of Araliaceae wilsonii.Alias sting bent stick, bank bent stick, 100 Pin, tiger are hasty and careless, slender acanthopanax ginseng, Russia's ginseng, siberian ginseng.Nature and flavor：Mildly bitter flavor；It is pungent；It is warm-natured, channel tropism：Returns spleen, kidney, the heart channel of Hang-Shaoyin. Function：Wind-damp dispelling, filling liver kidney, strengthening the bones and muscles,《Mingyi Bielu》Five are thought added with work(such as " bowl spares, strengthening the essence, hard muscles and bones, strong will " Effect.Contain by researching and analysing wilsonii Main Ingredients and Appearance：A variety of carbohydrates, amino acid, aliphatic acid, vitamin A, B1, B2 and volume Carrotene；Separately containing sesamin, sterol, coumarin, flavones, suberone, nonaro-maticity unsaturated organic acid and a variety of micro- Measure mineral matter etc..If discomfort, including melancholy, anxiety, allergy, insomnia etc. can then be caused by taking substantial amounts of wilsonii.With wind Moist cardiopathic patient take it is improper after then occur headache, palpitaition, pericardium pain, blood pressure rise etc. phenomenon.Very few User also have slight symptom of diarrhea.
Jasmine, alias：Jasmine, Latin literary fame：Jasminum sambac (L.) Ait, acrid, sweet, warm.Qi-regulating, is opened It is strongly fragrant, ward off dirty, and in.Every 100 grams of Jasmines 2~3 grams of oily matter containing volatilization, main component is phenmethylol or its lipid, jasmine Florigen, linalool, benzoic acid linalool ester etc., also containing shouting diindyl, the material such as jasmine lactone.
Experiment Introduction
1. screening experiment：According to a variety of anaesthetic proved recipes and relevant documentation ＆ info, in 20 plurality of raw materials medicines, fructus choerospondiatis, acid are selected Jujube kernel, wilsonii, Jasmine, four traditional Chinese medicine thing compatibility are used, and the outer bath anaesthetic of relieving mental strain and helping sleep is made.Fructus choerospondiatis, sweet, acid is mild-natured, Clear away heart-fire heat, cardiac stimulant, satisfying heat, treatment palpitaition, the disease such as heart failure, is equipped with that nature and flavor are sweet, acid, flat spina date seed, tonifying liver, calming heart, enhancing The effect of its heat that clears away heart-fire, antitoxic heart-soothing and sedative, be aided with filling liver kidney, the wilsonii of strengthening the bones and muscles makes antitoxic heart-soothing and sedative effect more strengthen, assistant with Qi-regulating, opens strongly fragrant, wards off dirty, and in Jasmine, gas is smooth along then blood, reaches the purpose mended without silt, above-mentioned four medicine complements each other, The effect of antitoxic heart-soothing and sedative, sleeping is played altogether.
In addition, there is numerous studies data to show：Spina date seed has good effect of calming the nerves, but due to being kind of a subclass medicinal material, it is inner Substantial amounts of grease is contained in face, and long-term taking can produce the side effect of diarrhea, if wilsonii is largely taken, can also produce discomfort, Said medicine is used it in outer bath anaesthetic, not only its active ingredient calmed the nerves can be entered by skin by rational compatibility Enter human body, into channels and collaterals, also escaped through the side effect, its medicine such as first pass effect of diarrhoea and medicine caused by gastrointestinal absorption In grease can also Glycerin.
In order to preferably play the curative effect of said medicine, the adverse reaction to human body, sufficiently effective utilization medicine are eliminated Resource, in addition scientific and reasonable compatibility forms the outer bath anaesthetic of the present invention, using water effect by internal heat evil and pathogenic QI in the body in In yellow water, then yellow water is discharged from pore, so as to improve the conspicuous operation according to, blood, reach effect of relieving mental strain and helping sleep, escaped liver Dirty first pass effect, it is to avoid medicine is by oral into digestive system and the adverse reaction that produces.
2. clinical comparison is tested
Any toxic side effect is not being found by toxicological test, and animal pharmacology effect experiment is achieved according on the basis of, is carried out Following clinical experiment.
（1）Diagnosis and treatment standard.
Medically judge that insomnia has strict definition, according to the World Health Organization (WHO) standard：1. continuous one month is weekly Occur within least 3 days going to bed 30 minutes and can not falling asleep;2. the daily length of one's sleep was less than 6.5 hours;3. the night in sleep procedure Number of times wake up more than 3 times, is difficult to fall asleep after waking up;4. dreaminess, the plot of bad dream is as TV series;After 5. next day gets up With not good, decrease of cognitive function of drowsiness, the tired, state of mind etc..In the presence of there are above-mentioned one of which or several simultaneously, i.e., It can determine that as insomnia.With reference to the features of the present invention, the standard of its treatment insomnia is formulated：1. recovery from illness：Above-mentioned insomnia disappears, and sleeps Sleep deep, it is hale and hearty after waking up.2. take a turn for the better：Insomnia is effectively improved, and the length of one's sleep, Depth of sleep increased more than 7.5 hours. 3. it is effective：Insomnia has been alleviated, more than 5.5 hours length of one's sleep but less than 7.5 hours.4：It is invalid：Insomnia without appoint What improves.
（2）Case selection：On the premise of patient is voluntary, 40 insomnias are selected to supply examination person, male 19 people, the people of female 21, age 30-60 years old, medical history 6 months-2 years.It is randomly divided into 2 groups, every group of 20 people.Experimental group：Treated with this dipping, 7 days as one therapeutic course, It is limited with two courses for the treatment of, application method：External application, full bath.15-25g of said medicine is taken, is put in the bathtub of suitable quantity of water, is stirred Make its diffusion uniform, keep 40 DEG C or so of water temperature, dipping about 20-40 minutes.Once a day, it is within seven days a course for the treatment of.According to the state of an illness Weight, can take the circumstances into consideration to be added and subtracted.Control group：Treated with oral zhusha anshen pills.It the results are shown in Table 1.
Calculation formula：Cure rate=（Healing number/sum）× 100%, total effective rate=（Sum-invalid number）/ sum × 100%。
It can be seen that, the effect of this drug therapy insomnia is substantially better than the curative effect of zhusha anshen pills, and therapeutic effect is notable.
Second of embodiment, the selection of bulk drug is with the first embodiment, and preparation method has changed compared with the first embodiment Enter.The preparation method of described bulk drug, it is characterised in that：Bulk drug is taken to be soaked in water by above-mentioned parts by weight, amount of water is Liquid medicine, is first fried open by 15-25 times of bulk drug gross weight with big fire, then is decocted 30 minutes with small fire, is filtered, and is dried, standby.
Application method：External application, full bath.10-15g of said medicine is taken, is put in the bathtub of suitable quantity of water, agitation expands it Dissipate uniform, keep 40 DEG C or so of water temperature, dipping about 20-40 minutes.Once a day, it is within seven days a course for the treatment of., can according to state of an illness weight Added and subtracted as one sees fit.
The experiment proved that, the drug effect of the present embodiment compared with the first embodiment without significant difference, but its medicine dosage significantly Reduction, is easy to packaging to carry, and is easy to use.
The third embodiment, the selection of bulk drug is with second of embodiment, and preparation method has changed compared with second of embodiment Enter.Analyze the chemical composition of each taste anaesthetic, with reference to the compatible experiments of prescription, improve preparation method, serious hope reach increase effectively into The stripping quantity divided, medicament-saving resource, the purpose heightened the effect of a treatment.
The preparation method of described bulk drug, takes above-mentioned other bulk drugs in addition to Jasmine by weight, adds former Expect 80% ethanol solution of 10-20 times of amounts of medicine gross weight, be heated to reflux 15 minutes, filter, filtrate is evaporated, and takes above-mentioned parts by weight jasmine The broken mesh sieve of mistake 60 of jasmine pollen, is evaporated thing with filtrate and is well mixed, plus ethyl acetate makes dissolving, adds ethyl acetate amount to submerge Crude drug, beyond medicinal material surface, 3-5cm is limited, ultrasonication 30min, filters, and dries, standby.
Application method：External application, full bath.5-10g of said medicine is taken, is put in the bathtub of suitable quantity of water, agitation spreads it Uniformly, 40 DEG C or so of water temperature, dipping about 20-40 minutes are kept.Once a day, it is within seven days a course for the treatment of.According to state of an illness weight, it can drink Feelings are added and subtracted.
It the experiment proved that, the drug effect of the present embodiment is substantially better than the first embodiment, and the dosage of its medicine is greatly reduced, It is easy to packaging to carry, is easy to use.
4th kind of embodiment, the selection of bulk drug is with the first embodiment, and preparation method has changed compared with the first embodiment Enter.Analyze the chemical composition of each taste anaesthetic, with reference to the compatible experiments of prescription, improve preparation method, serious hope reach increase effectively into The stripping quantity divided, medicament-saving resource, the purpose heightened the effect of a treatment.
The preparation method of the bulk drug, it is characterised in that：Above-mentioned raw materials medicine is taken by weight, is put into cryogenic vacuum expanded In machine, 0.5-0.6MPa is pressurized to, temperature control is below 65 DEG C, and decompression is produced, and is placed in decocting medicine pot, plus bulk drug gross weight 15-25 times of the milk or goat milk of amount, will first be fried open with high heat, then with being cooked by slow fire 30 minutes, filter, obtain filtrate, dry, It is standby.
Application method：External application, full bath.5-8g of said medicine is taken, is put in the bathtub of suitable quantity of water, agitation spreads it Uniformly, 40 DEG C or so of water temperature, dipping about 20-40 minutes are kept.Once a day, it is within seven days a course for the treatment of.According to state of an illness weight, it can drink Feelings are added and subtracted.
It the experiment proved that, medicine low temperature is produced into enhancing degree of grinding in preparation process remains the property of medicine again, is placed on milk Or decocted in goat milk, beneficial to the fried of active ingredient, and milk or goat milk have sedative action in itself, further enhance State the curative effect of medicine.Result of the test is shown：The drug effect of the present embodiment is set to be better than previous embodiment, and the dose ratio first of its medicine Plant embodiment to be greatly reduced, be easy to packaging to carry, also allow for using.
5th kind of embodiment, preparation method improves to some extent with second of embodiment, bulk drug compared with the first embodiment.It is described Bulk drug in add 5-8 parts of Fructus Dipsaci, 3-5 parts of fushen, 3-5 parts of the tuber of dwarf lilyturf, 2-3 parts of lily by weight.It is preferred that lettuce wins 6.5 parts of son, 4 parts of fushen, 4 parts of the tuber of dwarf lilyturf, 2.5 parts of lily.
Application method：External application, full bath.15-20g of said medicine is taken, is put in the bathtub of suitable quantity of water, agitation expands it Dissipate uniform, keep 40 DEG C or so of water temperature, dipping about 20-40 minutes.Once a day, it is within seven days a course for the treatment of., can according to state of an illness weight Added and subtracted as one sees fit.
Newly-increased bulk drug analysis：
Fructus Dipsaci, Mongolian name Shu Luhei-mire high pitch-crow heat, is feverfew lettuce Lactuca sativa L. seed. The property of medicine：Taste micro-sweet, it is mild-natured, imitate light, dry, blunt, rough.Major function：Clearing lung-heat heat, helps digestion, and whets the appetite, suppression it is conspicuous according to, cure mainly cough with lung heat, Chronic cough is not cured, lung abscess, is had a sleepless night, asthma, indigestion, nausea.
Fushen, fushen is the sleeping hole platymiscium Poria cocos of Polyporaceae（Poria cocos Schw.）Wolf sclerotium, the original It is rudimentary plant to plant, and is the fungi colonized on pine tree.Medicinal effects are the white portion that pine stump is entertained in the middle of dry sclerotia body. Nature and flavor are sweet, light flat.There are the functions such as excreting dampness, invigorating the spleen, calming heart.For phlegm and retained fluid, oedema, difficult urination, diarrhea, palpitaition, dizziness.
The tuber of dwarf lilyturf, the Mongolian power lattice of name A one hundred-Wen Dousu, is liliaceous plant tuber of dwarf lilyturf Ophiopogon japonicus (L.f.) Ker-Gawl. root tuber.Sweet, slight bitter is cool in nature.Major function：Calm down association's day, heat-clearing, removing toxic substances.Cure mainly headache, mouth Yearningly, mesh is yellow, and body is yellow, liver heat, gallbladder-heat, and intestines heat is scorchingly hot.Chemical composition：Root tuber examines sapogenin, potato containing ophiopogonin B, D and Ross Chinese yam sapogenin, tuber of dwarf lilyturf aglycon, borneol etc. are the glucosides of aglycon, the also A of ophiopogon flavonoid containing methyl, B, the flavonoids such as ophiopogonone Compound.
Lily, Mongolian name Sa Na, different name A Biha are liliaceous plant tiger lily, lily, the bulb of morningstar lily.It is sweet, it is micro- Hardship, it is cool in nature.Effect is light, blunt, dry, rough.Major function：Heat-clearing, removing toxic substances, synthetism, callus, hemostasis, dry Xieri Wusu Symptom, cough-relieving.Chemistry Composition：Lily bulb lily containing Ming River glucoside（regaloside）A, D, the asafoetide acyl sucrose of 3,6'-O- bis-（3,6'-O- diferuloylsucrose）, 1-O- asafoetide acyl glycerine（1-O-feruloylglycerol）, the p- coumaric acyl glycerine of 1-O-（1- O-p-coumaroylglycerol）, 26-O- β-D- glucopyranosyls-slave Ah sapogenin -3-O- α-L- rhamnopyranosyls - （1→2）- β-D- glucopyanosides (26-O- β-D-glucopyranosylnuatigenin-3-O- α-L- rhamnopyranosyl（1→2）- β-D-glucopyranoside), 26-O- β-D- glucopyranosyls-slave Ah sapogenin- 3-O- α-L- rhamnopyranosyls-（1→2）- O- [β-D- glucopyranosyls（1→4）]-β-D- glucopyanosides.
Increase medicine property of medicine analysis：Add taste micro-sweet, mild-natured Fructus Dipsaci, with fructus choerospondiatis, spina date seed, wilsonii, Jasmine Compatibility, while enhancing insomnia effect, clearing lung-heat heat helps digestion, whetted the appetite, and suppression is conspicuous according to treatment patient is due to apocleisis, face caused by insomnia The thin symptom of yellow flesh, is equipped with the functions such as nature and flavor sweet, the light flat invigorating the spleen of fushen's enhancing Fructus Dipsaci, calming heart, cool in nature with sweet, slight bitter The tuber of dwarf lilyturf, lily help fructus choerospondiatis clear away heart-fire heat, calm the nerves, all medicine compatibilities, the effect of playing relieving mental strain and helping sleep altogether so as to strengthen sedative action, is expanded The therapeutic domain of big treatment insomniac, improves the effective percentage for the treatment of.
Experiment Introduction：
On the premise of patient is voluntary, 20 insomnias are selected to supply examination persons, male 9 people, the people of female 11,30-60 years old ages, medical history 6 months- 2 years.Experimental group：Treated with this dipping, 7 days as one therapeutic course is limited with two courses for the treatment of.Application method：External application, full bath.Take 15-20g of medicine is stated, is put in the bathtub of suitable quantity of water, agitation makes its diffusion uniform, keeps 40 DEG C or so of water temperature, dipping about 20- 40 minutes.Once a day, it is within seven days a course for the treatment of.According to state of an illness weight, it can take the circumstances into consideration to be added and subtracted.Control group：Implemented with the first The experimental group data of example are reference.Diagnosis and treatment standard are with reference to the first embodiment.It the results are shown in Table 2.
Calculation formula：Cure rate=（Healing number/sum）× 100%, total effective rate=（Sum-invalid number）/ sum × 100%。
It can be seen that, the effect of this drug therapy insomnia is substantially better than the curative effect of the first embodiment, have received unexpected Therapeutic effect.
6th kind of embodiment, is improved on the basis of the 5th kind of embodiment to preparation method.Preparation method is with the third Embodiment, the selection of bulk drug is with the 5th kind of embodiment.
Application method：External application, full bath.5-10g of said medicine is taken, is put in the bathtub of suitable quantity of water, agitation spreads it Uniformly, 40 DEG C or so of water temperature, dipping about 20-40 minutes are kept.Once a day, it is within seven days a course for the treatment of.According to state of an illness weight, it can drink Feelings are added and subtracted.
It the experiment proved that, the drug effect of the present embodiment is better than previous embodiment, and the 5th kind of embodiment of dose ratio of its medicine It is greatly reduced, is easy to packaging to carry, is easy to use.
7th kind of embodiment, is improved on the basis of the 5th kind of embodiment to preparation method.Preparation method is with the 4th kind Embodiment, the selection of bulk drug is with the 5th kind of embodiment.
Application method：External application, full bath.5-10g of said medicine is taken, is put in the bathtub of suitable quantity of water, agitation spreads it Uniformly, 40 DEG C or so of water temperature, dipping about 20-40 minutes are kept.Once a day, it is within seven days a course for the treatment of.According to state of an illness weight, it can drink Feelings are added and subtracted.
It the experiment proved that, the drug effect of the present embodiment is better than previous embodiment, and the 5th kind of embodiment of dose ratio of its medicine It is greatly reduced, is easy to packaging to carry, is easy to use.
8th kind of embodiment, preparation method improves to some extent with second of embodiment, bulk drug compared with the 5th kind of embodiment.It is described Bulk drug in add keel 1-2,1-2 parts of gypsum, 0.5-1 part of red Bo by weight, preferably keel 1.5,1.5 parts of gypsum, Red 0.8 part of Bo.
Application method：External application, full bath.15-25g of said medicine is taken, is put in the bathtub of suitable quantity of water, agitation expands it Dissipate uniform, keep 40 DEG C or so of water temperature, dipping about 20-40 minutes.Once a day, it is within seven days a course for the treatment of., can according to state of an illness weight Added and subtracted as one sees fit.
Newly-increased bulk drug analysis：
Keel, Mongolian name Lu-Ya Si, different name cloth such as lattice are auspicious, be ancient times mammal as class, rhinoceros class, Hippocampal cortex class Skeleton Stone.It is sweet, puckery, it is mild-natured.Major function：Kill viscous, only shouting pain, only corruption, myogenic is held back wound, calmed the nerves.Cure mainly brain shouting pain, injured bones and muscles, Fracture, sword wound, night sweat, seminal emission, gonorrhoea, insomnia and dreamful sleep, bar cloth disease.Main chemical compositions：Predominantly calcium carbonate, calcium phosphate, still Iron content, potassium, receive, chlorine, sulfate etc..
Gypsum, Mongolian name Chao Lun-bamboo ridge, different name road Zhu Gang exhales Le Tege.For Sulfates mineral gypsum.Taste micro-sweet, It is cool in nature.Effect it is soft, again, it is blunt.Heat-clearing, cough-relieving, callus, removing jaundice.Cough with lung heat is cured mainly, lung chronic illness is got mildewed in warm conditions, fractured, jaundice.Chemistry into Point：It is main to contain the calcium sulfate with the crystallization water.In addition, often there is the impurity such as clay, sand grains, organic matter, sulfide to be mixed into.
Red Bo, Mongolian name Ao Le hair colors, different name A Ledun wood, promise glycolylurea-great Kazakhstan, conspicuous hot sound-He Muhe.Planted for Curcurbitaceae The fruit of the red Bo of thing.It is sweet, bitter, sour, mild-natured.Major function：Promoting blood circulation, stagnation resolvation, menstruation regulating.Cure mainly in vaginal disease, blood stasis palace, blood Ruffian, Amenorrhea, angiopathy, skin disease.
Add medicine property of medicine analysis：Sweet, puckery, mild-natured keel are added, taste micro-sweet, gypsum cool in nature strengthens work of calming the nerves With while, heat-clearing, callus, analgesic, treatment the accessory symptoms such as are ached due to muscles and bones caused by insomnia, sweet, bitter, sour, mild-natured Red Bo, promoting blood circulation, stagnation resolvation promote skin blood circulation, and channels and collaterals of releiving by above-mentioned compatibility, for enhancing relieving mental strain and helping sleep effect, are received Unexpected therapeutic effect is arrived.
Experiment Introduction：
On the premise of patient is voluntary, 20 insomnias are selected to supply examination person, male 10 people, the people of female 10,30-60 years old ages, medical history 6 - 2 years moon.Experimental group：Treated with this dipping, 7 days as one therapeutic course is limited with two courses for the treatment of.Application method：External application, full bath. 15-25g of said medicine is taken, is put in the bathtub of suitable quantity of water, agitation makes its diffusion uniform, keeps 40 DEG C or so of water temperature, dipping is about 20-40 minutes.Once a day, it is within seven days a course for the treatment of.According to state of an illness weight, it can take the circumstances into consideration to be added and subtracted.Control group：With the first reality The experimental group data for applying example are reference.Diagnosis and treatment standard are with reference to the first embodiment.It the results are shown in Table 3.
Calculation formula：Cure rate=（Healing number/sum）× 100%, total effective rate=（Sum-invalid number）/ sum × 100%。
It can be seen that, the effect of this drug therapy insomnia is substantially better than the curative effect of the first embodiment, and therapeutic effect is notable.
9th kind of embodiment, is improved on the basis of the 8th kind of embodiment to preparation method.Preparation method is with the third Embodiment, the selection of bulk drug is with the 8th kind of embodiment.
Application method：External application, full bath.5-12g of said medicine is taken, is put in the bathtub of suitable quantity of water, agitation spreads it Uniformly, 40 DEG C or so of water temperature, dipping about 20-40 minutes are kept.Once a day, it is within seven days a course for the treatment of.According to state of an illness weight, it can drink Feelings are added and subtracted.
It the experiment proved that, the drug effect of the present embodiment is better than previous embodiment, and the 8th kind of embodiment of dose ratio of its medicine It is greatly reduced, is easy to packaging to carry, is easy to use.
Tenth kind of embodiment, is improved on the basis of the 8th kind of embodiment to preparation method.Preparation method is with the 4th kind Embodiment, the selection of bulk drug is with the 8th kind of embodiment.
Application method：External application, full bath.4-8g of said medicine is taken, is put in the bathtub of suitable quantity of water, agitation spreads it Uniformly, 40 DEG C or so of water temperature, dipping about 20-40 minutes are kept.Once a day, it is within seven days a course for the treatment of.According to state of an illness weight, it can drink Feelings are added and subtracted.
It the experiment proved that, the drug effect of the present embodiment is better than previous embodiment, and the 8th kind of embodiment of dose ratio of its medicine It is greatly reduced, is easy to packaging to carry, is easy to use.
Embodiment described above simply to the present invention preferably scheme, not does any formal limitation to the present invention, There are other variants and remodeling on the premise of without departing from the technical scheme described in claim.

Claims (7)

1. a kind of outer bath anaesthetic of relieving mental strain and helping sleep, it is characterized in that：The outer bath anaesthetic of the relieving mental strain and helping sleep includes following by weight Bulk drug：10-25 parts of fructus choerospondiatis, 10-25 parts of spina date seed, 10-25 parts of wilsonii, 0.5-1 part of Jasmine.
2. a kind of outer bath anaesthetic of relieving mental strain and helping sleep according to claim 1, it is characterised in that：Described bulk drug is by weight Part includes：18 parts of fructus choerospondiatis, 18 parts of spina date seed, 18 parts of wilsonii, 0.3 part of Jasmine.
3. a kind of outer bath anaesthetic of relieving mental strain and helping sleep according to claim 1, it is characterised in that：By weight in described bulk drug Measure part and add 5-8 parts of Fructus Dipsaci, 3-5 parts of fushen, 3-5 parts of the tuber of dwarf lilyturf, 2-3 parts of lily.
4. a kind of outer bath anaesthetic of relieving mental strain and helping sleep according to claim 3, it is characterised in that：By weight in described bulk drug Measure part and add keel 1-2,1-2 parts of gypsum, 0.5-1 part of red Bo.
5. a kind of preparation method of the outer bath anaesthetic of relieving mental strain and helping sleep according to claim 1 or 2 or 3 or 4, its feature exists In：Bulk drug is taken to be soaked in water by above-mentioned parts by weight, amount of water is 15-25 times of bulk drug gross weight, first with big fire by medicine Decocting is opened, then is decocted 30 minutes with small fire, is filtered, and is dried, standby.
6. a kind of preparation method of the outer bath anaesthetic of relieving mental strain and helping sleep according to claim 1 or 2 or 3 or 4, its feature exists In：Above-mentioned other bulk drugs in addition to Jasmine are taken by weight, add 80% ethanol of 10-20 times of amounts of bulk drug gross weight Solution, is heated to reflux 15 minutes, and filtration, filtrate is evaporated, takes above-mentioned parts by weight Jasmine to crush 60 mesh sieves, thing is evaporated with filtrate It is well mixed, plus ethyl acetate makes dissolving, adds ethyl acetate amount to submerge crude drug, 3-5cm is beyond medicinal material surface Limit, ultrasonication 30min is filtered, and is dried, standby.
7. a kind of preparation method of the outer bath anaesthetic of relieving mental strain and helping sleep according to claim 1 or 2 or 3 or 4, its feature exists In：Above-mentioned raw materials medicine is taken by weight, is put into cryogenic vacuum bulking machine, is pressurized to 0.5-0.6MPa, temperature control is at 65 DEG C Hereinafter, decompression is produced, and is placed in decocting medicine pot, plus bulk drug gross weight 15-25 times of milk or goat milk, first with high heat will decoct Open, then with being cooked by slow fire 30 minutes, filter, obtain filtrate, dry, it is standby.
CN201710250741.9A 2017-04-18 2017-04-18 A kind of outer bath anaesthetic of relieving mental strain and helping sleep and preparation method thereof Pending CN107007665A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112316066A (en) * 2020-10-30 2021-02-05 广西中医药大学赛恩斯新医药学院 Jasmine flower-containing traditional Chinese medicine formula brown sugar capable of soothing nerves and helping sleep and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
吕炳奎: "《家庭营养师》", 31 January 2002, 九州出版社 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112316066A (en) * 2020-10-30 2021-02-05 广西中医药大学赛恩斯新医药学院 Jasmine flower-containing traditional Chinese medicine formula brown sugar capable of soothing nerves and helping sleep and preparation method thereof

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