CN106983951A - A kind of analyte monitoring and automatic chemical feeding system - Google Patents

A kind of analyte monitoring and automatic chemical feeding system Download PDF

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Publication number
CN106983951A
CN106983951A CN201710308313.7A CN201710308313A CN106983951A CN 106983951 A CN106983951 A CN 106983951A CN 201710308313 A CN201710308313 A CN 201710308313A CN 106983951 A CN106983951 A CN 106983951A
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China
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injection
blood glucose
unit
days
overall
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CN201710308313.7A
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Chinese (zh)
Inventor
张艳
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Gansu Aipu Kangrui Biotechnology Co.,Ltd.
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Individual
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Priority to CN201710308313.7A priority Critical patent/CN106983951A/en
Publication of CN106983951A publication Critical patent/CN106983951A/en
Priority to PCT/CN2018/084236 priority patent/WO2018201931A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring

Abstract

The present invention provides a kind of analyte monitoring and automatic chemical feeding system, including：Detection unit, detection unit includes at least two detection parts, and each detection part is used to test and analyze the analysis object in thing；Processing unit；Computing unit；And injecting unit, total injection volume that injecting unit calculates obtained medicine according to computing unit injects medicine, and injecting unit includes at least two injection members, wherein each injection member is used to inject medicine；Control unit, control unit control detection unit, processing unit, computing unit and injecting unit.According to analyte monitoring provided by the present invention and automatic chemical feeding system, (such as glucose, oxygen, triglycerides or ketoboidies) concentration of analyte can be accurately monitored using simple device, and drug injection can be carried out simultaneously by least two injection members, drug injection area can effectively be increased, it is obviously improved callosity, and effectively strengthen drug absorption effect, lift therapeutic effect.

Description

A kind of analyte monitoring and automatic chemical feeding system
Technical field
It is used to monitor analyte (such as glucose or blood ketone) and corresponding automatic chemical feeding system the present invention relates to one kind. More particularly, the present invention relate to given automatically using electrochemical sensor monitoring body analytes and according to monitoring result The system of medicine.
Background technology
Diabetes are our relatively common diseases in life.It is well known that diabetes be one group using hyperglycaemia as spy The metabolic disease levied, its cause is that pancreas can not produce the insulin of sufficient amount, so as to cause body metabolism glucose Ability is reduced, and thus causes hyperglycaemia (there is excessive glucose in blood plasma).By the discovery that studies for a long period of time, persistence is high Blood glucose and/or hypoinsulinemia are associated with the complication of a variety of serious symptoms and threat to life, such as dehydration, ketoacidosis Disease, angiocardiopathy, chronic renal failure, retinal damage and various neuronal damages.With the improvement of living standards, diabetes Occurrence probability is also more and more higher.Especially in recent years, the diabetes popularity of China shows rapid increase and rejuvenation Trend.
But, current medical level is flourishing not enough, the method for also not yet finding radical cure diabetes, can only be by detection side The blood glucose of method detection diabetic carrys out the symptom of reduction of patient in this way so as to adjust the dosage of hypoglycemic drug.
In the last few years, the main flow monitoring method of blood glucose was finger tip blood sugar test, i.e., by syringe needle thorn finger, collect blood Reflect with test paper the blood sugar level in human body after liquid.Also it is numerous diabetics although Fingertip blood glucose test is simple and convenient Receive and apply.But, in most cases, diabetic can only be in discrete time one by one by Fingertip blood glucose measurement Completed on point, this metering system can not show the variation tendency of the blood sugar level of patient in one period.Therefore, even if most Positive frequent blood glucose measurement person, the hyperglycaemia or hypoglycemia occurred when can not also find those, it is difficult to observe blood glucose fluctuation Concrete condition.Especially when night.In addition, this method is also inconvenient to carry out blood glucose level data record to patient.This Outside, because the uniformity change between individuals of blood glucose level monitor is very big.Many diabetics have found routine test very Inconvenience, and often forget to test its blood sugar level, or without the appropriate test of time progress.Further, since existing Blood sugar monitoring methods need to utilize punctures finger, be certain to cause patient to produce pain, so as to cause patient's heart In to monitoring contradict, to wish to avoid to test caused pain.
Further, in these years, although have been developed that many devices, for it is continuous or automatically monitor blood flow or Analyte in matter liquid, such as glucose.Many such devices use electrochemical sensor.However, these devices are needed mostly It is implanted directly into the blood vessel of patient or in hypodermis, is not only difficult to reproduce or inexpensively produce on a large scale, and These devices are generally large, heaviness, and/or dumb, and much can not be in controlled medical facilities (such as hospital or doctor Office) outside effectively utilize, this greatly limits the freedom of movement of patient.
Further, in existing diabetes remedy, injection of insulin is most directly to control diabetic condition Medical means.In recent years, patient is great for the demand of automatic, portable insulin injection device.However, existing pancreas Island element injection device still has many deficiencies：
Existing insulin injection device typically carries out the injection of insulin using conventional needle, and syringe needle is puncturing skin There is obvious pain during skin.Meanwhile, if the existing insulin injection device of patient's long periods of wear is, it is necessary to which syringe needle prolonged stay is in skin In skin, then need to take disinfectant measure often, otherwise wound infection can be caused due to sweat etc..Further, since syringe needle carries out pancreas Island element injection needs to be pierced into skin corium, and syringe needle is typically longer, and long periods of wear is also easily caused skin scar.
Further, since existing wait insulin injection device to carry out injection of insulin using conventional needle, injection position is concentrated, Generation subcutaneous induration at injection position is easily caused, discomfort is brought to patient.Further, because injection position is concentrated, hold Absorption of insulin is easily caused slower, so as to cause therapeutic effect not good.
The content of the invention
The task of the present invention is that there is provided a kind of analyte monitoring and automatic chemical feeding system, it is possible to resolve divide in the prior art Analyse it is that thing monitoring and automatic chemical feeding system are present in-convenience in use, pain is produced to patient and production cost is higher, volume Larger the problems such as, and further solve it is that medicament injection apparatus in the prior art is present in-convenience in use, pain is produced to patient The problems such as sense and drug absorption are slow, therapeutic effect is not good.
In order to solve the above problems, the present invention provides a kind of analyte monitoring and automatic chemical feeding system, including：Detection is single Member, detection unit includes at least two detection parts, and each detection part is used to test and analyze the analysis object in thing；Processing Unit, processing unit is analyzed and processed to the testing result of each detection part, to obtain the detection with each detection part As a result corresponding processing numerical value；Computing unit, the computing unit pair processing numerical value corresponding with each detection part compares Relatively calculate, to obtain at-once monitor result, also, computing unit is additionally operable to calculate total injection volume of medicine；And injecting unit, note Total injection volume injection medicine that unit calculates obtained medicine according to computing unit is penetrated, and injecting unit includes at least two notes Part is penetrated, wherein each injection member is used to inject medicine；And, control unit, control unit control detection unit, processing Unit, computing unit and injecting unit.
According to analyte monitoring provided by the present invention and automatic chemical feeding system, can accurately it be supervised using simple device Survey (such as glucose, oxygen, triglycerides or ketoboidies) concentration of analyte.Further, at least two injection members can be passed through Drug injection is carried out simultaneously, can effectively increase drug injection area, hence it is evident that is improved callosity, and is effectively strengthened medicine Thing assimilation effect, lifts therapeutic effect.
Further, the analyte monitoring provided according to another aspect of the present invention and automatic chemical feeding system, wherein：Calculate Unit is according to content of triglyceride, blood sugar monitoring value and recent change of blood sugar trend meter in the body weight of patient, waist-to-hipratio, blood Calculate total injection volume of medicine.
Further, the analyte monitoring provided according to another aspect of the present invention and automatic chemical feeding system, wherein, each Detection part is electrochemical sensor, including working electrode and reference electrode；Processing unit is by the work in each detection part Electric signal between electrode and reference electrode is analyzed and processed, so as to obtain corresponding analysis knot corresponding to each detection part Really；Also, injecting unit also includes drug storage part, medicine distribution circuit and syringe pump；Wherein, control unit is single according to calculating The total injection volume for the medicine that member is calculated, is controlled to syringe pump, the medicine in drug storage part is passed through according to required amount Medicine distribution circuit is sent to injection member.
It is preferred that the analyte monitoring provided according to another aspect of the present invention and automatic chemical feeding system, are further wrapped Include：Substrate, substrate is formed by flexible material；Also, each working electrode and each reference electrode in detection unit are respectively formed The acicular member of a side surface of substrate is attached to for one end, and the other end of each working electrode and each reference electrode is formed For tip；Each injection member in injecting unit be formed as one end attach to substrate it is a side surface, be internally formed stream The acicular member of body passage, and the other end of each injection member is formed as tip.
Further, the analyte monitoring provided according to another aspect of the present invention and automatic chemical feeding system, wherein：Calculate Unit is according to content of triglyceride, preprandial glucose monitor value and change of blood sugar in three days in the body weight of patient, waist-to-hipratio, blood Trend calculates total injection volume of medicine；And
Computing unit calculates total injection volume of medicine according to below equation：
Wherein：
L1：The total injection volume (u) for the medicine that computing unit is calculated；
K：Inject the body weight (Kg) of object；
Y：Inject the waist-to-hipratio of object；
X：Triglycerides (mmol/L) content in the blood of object is injected, wherein：
When content of triglyceride is below 1.7：X=1；
Content of triglyceride is more than 1.7 and when below 2.5：X=1.1；
Content of triglyceride is more than 2.5 and when below 5：X=1.2；
Content of triglyceride is more than 5 and when below 10：X=1.3；
When content of triglyceride is more than 2.5 and is less than 5：X=1.4；
A：Inject odd-numbered day preprandial glucose (mmol/L) average of object；
a：Preprandial glucose variation tendency in three days of object is injected, wherein：
When preprandial glucose change is overall when within ± the 5% of initial measurement in three days of injection object：A=1；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is compared to ascending amount when within 10%：A=1.1；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is more than 10% and when within 20% compared to ascending amount：A=1.2；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is more than 20% and when within 30% compared to ascending amount：A=1.3；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is more than 30% and when within 40% compared to ascending amount：A=1.4；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum When value is more than 40% compared to ascending amount：A=1.5；And
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is compared to slippage when within 10%：A=0.9；
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is more than 10% and when within 20% compared to slippage：A=0.8；
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is more than 20% and when within 30% compared to slippage：A=0.7；
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is compared to slippage when within 40%：A=0.6.
Further, the analyte monitoring provided according to another aspect of the present invention and automatic chemical feeding system, wherein：Calculate Unit according to content of triglyceride in the body weight of patient, waist-to-hipratio, blood, preprandial glucose monitor value, postprandial blood sugar monitor value, with And change of blood sugar trend calculates total injection volume of medicine in three days；And
Computing unit calculates total injection volume of medicine according to below equation：
Wherein：
L2：The total injection volume (u) for the medicine that computing unit is calculated；
K：Inject the body weight (Kg) of object；
Y：Inject the waist-to-hipratio of object；
X：Triglycerides (mmol/L) content in the blood of object is injected, wherein：
When content of triglyceride is below 1.7：X=1；
Content of triglyceride is more than 1.7 and when below 2.5：X=1.1；
Content of triglyceride is more than 2.5 and when below 5：X=1.2；
Content of triglyceride is more than 5 and when below 10：X=1.3；
When content of triglyceride is more than 2.5 and is less than 5：X=1.4；
A：Inject odd-numbered day preprandial glucose (mmol/L) average of object；
a：Preprandial glucose variation tendency in three days of object is injected, wherein：
When preprandial glucose change is overall when within ± the 5% of initial measurement in three days of injection object：A=1；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is compared to ascending amount when within 10%：A=1.1；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is more than 10% and when within 20% compared to ascending amount：A=1.2；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is more than 20% and when within 30% compared to ascending amount：A=1.3；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is more than 30% and when within 40% compared to ascending amount：A=1.4；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum When value is more than 40% compared to ascending amount：A=1.5；And
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is compared to slippage when within 10%：A=0.9；
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is more than 10% and when within 20% compared to slippage：A=0.8；
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is more than 20% and when within 30% compared to slippage：A=0.7；
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is compared to slippage when within 40%：A=0.6；And
B：Inject odd-numbered day postprandial blood sugar (mmol/L) average of object；
b：Postprandial blood sugar variation tendency in three days of object is injected, wherein：
When postprandial blood sugar change is overall when within ± the 5% of initial measurement in three days of injection object：A=1；
When postprandial blood sugar change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is compared to ascending amount when within 10%：A=1.1；
When postprandial blood sugar change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is more than 10% and when within 20% compared to ascending amount：A=1.2；
When postprandial blood sugar change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is more than 20% and when within 30% compared to ascending amount：A=1.3；
When postprandial blood sugar change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is more than 30% and when within 40% compared to ascending amount：A=1.4；
When postprandial blood sugar change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum When value is more than 40% compared to ascending amount：A=1.5；And
When postprandial blood sugar change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is compared to slippage when within 10%：A=0.9；
When postprandial blood sugar change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is more than 10% and when within 20% compared to slippage：A=0.8；
When postprandial blood sugar change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is more than 20% and when within 30% compared to slippage：A=0.7；
When postprandial blood sugar change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is compared to slippage when within 40%：A=0.6；And
Early drug injection amount L before the meal21=L2×0.6；
Drug injection amount L before dinner22=L2×0.4。
It is preferred that the analyte monitoring provided according to another aspect of the present invention and automatic chemical feeding system, wherein：Each The outer surface of working electrode is additionally provided with electro transfer layer.
It is preferred that the analyte monitoring provided according to another aspect of the present invention and automatic chemical feeding system, wherein：Each Working electrode in detection part is formed from reference electrode by different materials.
It is preferred that the analyte monitoring provided according to another aspect of the present invention and automatic chemical feeding system, are further wrapped Include：Personal information can be inputted analyte monitoring and automatic chemical feeding system by input block, user by input block, and Computing unit is calculated according to the personal information inputted in use；Setup unit, user can be by setup unit to dividing Analysis thing monitoring is set with automatic chemical feeding system；Also, input block, setup unit are electrically connected with control unit.
It is preferred that the analyte monitoring provided according to another aspect of the present invention and automatic chemical feeding system, are further wrapped Include：Comparing unit, the processing numerical value corresponding with the testing result of each detection part that comparing unit is obtained to processing unit Compared one by one respectively, and the monitoring fiducial value obtained more afterwards one by one is compared respectively with monitoring threshold set in advance Compared with；Also, the total injection volume for the medicine that comparing unit calculates computing unit is compared with medication threshold value；And Tip element, If total injection volume that the monitoring fiducial value that comparing unit is obtained is more than the medicine that monitoring threshold and/or computing unit are calculated is less than Medication threshold value, Tip element sends cue；Also, comparing unit and Tip element are electrically connected with control unit respectively.
Further, the analyte monitoring provided according to another aspect of the present invention and automatic chemical feeding system, are further wrapped Include：Display unit, display unit is used for the result of calculation for showing computing unit；And storage element, storage element is to computing unit Result of calculation stored；Also, display unit is electrically connected with control unit respectively with storage element.
Further, the analyte monitoring provided according to another aspect of the present invention and automatic chemical feeding system, are further wrapped Include：Transmitter unit, the result of calculation that transmitter unit is stored in the result of calculation and/or storage element for sending computing unit.
Further, the analyte monitoring provided according to another aspect of the present invention and automatic chemical feeding system, wherein：Processing Unit, computing unit, display unit, storage element, comparing unit, input block, setup unit, Tip element, transmitter unit And control unit is packaged in same housing.
For the above of the present invention can be become apparent, preferred embodiment cited below particularly, and with reference to accompanying drawing, make detailed It is described as follows.
Brief description of the drawings
The present invention is introduced below in conjunction with accompanying drawing.
Fig. 1 is to show the analyte monitoring according to the present invention and the block schematic illustration of automatic chemical feeding system；
Fig. 2 a be show the detection unit 1 of analyte monitoring and automatic chemical feeding system according to the present invention, injecting unit 4 with The side structure schematic view of substrate 14；
Fig. 2 b be show the detection unit 1 of analyte monitoring and automatic chemical feeding system according to the present invention, injecting unit 4 with The stereopsis structural representation of substrate 14.
Embodiment
Embodiments of the present invention are illustrated by particular specific embodiment below, skilled person can be by this Content disclosed in specification understands other advantages and effect of the present invention easily.
Such as a kind of rear attached Figure of description 1 to the analyte monitoring and automatic chemical feeding system provided shown in 2b according to the present invention System, including：Detection unit 1, the detection unit 1 includes at least two detection parts 11, and each detection part 11 is used to detection Analysis object in analyte.More specifically, the analyte monitoring provided according to the present invention can be used with automatic chemical feeding system In the concentration for determining people's bodily analytes (for example, glucose or blood ketone in body fluid).For example, between continuous or periodic monitoring patient Analyte in matter liquid, and then the glucose level that can be used to refer in patient's blood flow.Further, provided according to the present invention Analyte monitoring and automatic chemical feeding system, detection part 11 can be implantable sensor, can also use other internal points Thing sensor is analysed, for inserting vein or other internal positions comprising body fluid.Typically, according to analysis provided by the present invention Thing monitoring is configured for monitoring patient analyte level interior for a period of time with automatic chemical feeding system, and (this period can With from a few days to a few weeks or longer time).Further, detection unit 1 can also including ampere meter etc. circuit reading part Part, to obtain the signal of each detection part 11, obtains testing result.
Further, the analyte monitoring also includes processing unit 2 with automatic chemical feeding system, and processing unit 2 is to detection unit 1 In the testing result of each detection part 11 analyzed and processed, it is relative with the testing result of each detection part 11 to obtain The processing numerical value answered.Further, to those skilled in the art, the testing result (signal) from each detection part 11 Typically there is at least one feature, for example, the change of the electric current, voltage or frequency with the change in concentration of analyte.For example, such as Fruit detection part 11 is operated using ampere meter, then signal code changes with analyte concentration.In the present invention, processing unit 2 can carry out rectification to the testing result of each detection part 11 and read, and change what is be adapted with analyte concentration to obtain Handle numerical value.In addition, the message part that treatment in accordance with the present invention unit 2 can also include carrying testing result is special from one kind Levy the circuit for being converted into another feature.For example, if detection part 11 is operated using ampere meter, signal code is with analysis Thing concentration and change, in this case, processing unit 2 can be current-voltage or current-frequency converter.This conversion Purpose can be to provide for example be more easy to transmission, be more easy to the signal that is read by digital circuit, it is and/or less affected by noise.
Further, the analyte monitoring and automatic chemical feeding system also include computing unit 3,3 pairs of computing unit with it is each The corresponding processing numerical value of detection part 11 is compared calculating, to obtain result of calculation.More specifically, due to detection unit 1 includes at least two detection parts 11, and processing unit 2 can be analyzed and processed to the testing result of each detection part 11, So as to obtain at least two corresponding processing numerical value.Further, according to 2 pair of at least two processing number of computing unit of the present invention Value is compared calculating, for example, averaging calculating is carried out at least two processing numerical value, so as to obtain accurate result of calculation. Further, the computing unit 3 in analyte monitoring provided by the present invention and automatic chemical feeding system can also be used to calculate Total injection volume of medicine, for example, obtained result of calculation is calculated according to the computing unit 3, the personal letter that combined use person provides Breath, is calculated total injection volume of the medicine of required injection.
Further, the analyte monitoring also includes injecting unit 4 with automatic chemical feeding system, and the injecting unit 4 is according to meter Total injection volume injection medicine that unit 3 calculates obtained medicine is calculated, and injecting unit 4 includes at least two injection members 41, Wherein each injection member 41 is used to inject medicine.More specifically, according to the analyte monitoring of the invention provided and automatically In delivery system, injection member 11 can be implantable syringe, can also use other internal injection devices, quiet for inserting Arteries and veins or other internal positions comprising body fluid.
Further, the analyte monitoring also includes control unit 5,5 pairs of detections of the control unit with automatic chemical feeding system Unit 1, processing unit 2, computing unit 3, injecting unit 4 are controlled.More specifically, the control unit 5 can be according to making The setting of user is controlled to detection unit 1, and/or injecting unit 4 is controlled according to the result of calculation of computing unit 3 System.
As described above, can be used in monitoring patient for a period of time according to the analyte monitoring of the present invention and automatic chemical feeding system Interior analyte (such as glucose, oxygen, triglycerides or ketoboidies) level, further, can be by control unit 5 to injection part At least two injection members 41 of part 4 are controlled, to cause injection member 41 while drug injection is carried out, so as to effective Ground increases drug injection area, hence it is evident that improve callosity, and effectively strengthens drug absorption effect, lifts therapeutic effect. Therefore, such as on-off circuit, clock can be included according to the analyte monitoring of the present invention and the control unit 5 of automatic chemical feeding system Circuit etc. controls circuit, so that detection unit 1, processing unit 2, computing unit 3 and injecting unit 4 are respectively controlled, from And detection unit 1 can be utilized in predetermined instant (for example, every two hours or longer time) to the analyte level of patient It is monitored, and testing result is divided using processing unit 2 and computing unit 3 after each detection unit 1 completes detection Analysis processing and calculating, acquisition can accurately react the result of calculation of patient analyte level, and according to the calculating knot of computing unit 3 Really, control injecting unit 4 carries out accurate injection.
Further, according to analyte monitoring provided by the present invention and automatic chemical feeding system, detection unit 1 includes at least two Individual detection part 11, each detection part 11 is electrochemical sensor, and including working electrode 12 and reference electrode 13.More For specifically, in the present invention, " electrochemical sensor " is arranged to by electrochemical oxidation on a sensor and reduction React to detect the presence of the analyte in sample and/or measure the device of its level.Further, the electrochemical sensor includes The working electrode 12 of " paired electrode " form of presentation and reference electrode 13, wherein, by the electric current of working electrode 12 with passing through ginseng The current amplitude for examining the electric current of electrode 13 is equal but symbol is opposite.Further, by working electrode 12 and reference electrode 13 so Configuration, analyte can directly on working electrode 12 or through one or more electron transfer agents occur analyte electric oxygen Change or electro-reduction reaction, and be the electric signal related to the amount, concentration or level of the analyte in sample by these reaction conversions.
More specifically, according to analyte monitoring provided by the present invention and automatic chemical feeding system, processing unit 2 will be each The electric signal between working electrode 12 and reference electrode 13 in detection part 11 is analyzed and processed, so that corresponding to each inspection Survey part 11 and obtain corresponding analysis result.For example, after current potential is applied between working electrode 12 and reference electrode 13, it will There is electric current flowing.Electric current is electroxidation or the result of electro-reduction reaction, and processing unit 2 can directly read the size of electric current, from And using the size of the electric current is as the processing numerical value corresponding with the testing result of each detection part 11 and then reflects analyte Amount, concentration or level height.Or, the processing unit 2 can also be current-voltage or current-frequency converter, so that will The electric current that detection part 11 is obtained is converted to voltage or frequency modulation be more easy to transmission, be more easy to the signal that is read by digital circuit, And/or it is less affected by noise.
Further, according in analyte monitoring provided by the present invention and automatic chemical feeding system：Injecting unit 4 also includes storage Further, control unit 5 is according to computing unit by medicine part (not shown), medicine distribution circuit 43 and syringe pump (not shown) 2 result of calculation, is controlled to syringe pump, and the medicine in drug storage part is passed through into medicine distribution circuit according to required amount It is sent to each injection member 41.What is needed herein is, although drug storage part, medicine are not distributed in accompanying drawing of the present invention The structure of path 43 and syringe pump makes diagram, to those skilled in the art, according to actual design and can use need Will, the concrete structure of the drug storage part, medicine distribution circuit 43 and syringe pump is arbitrarily set, and this does not simultaneously need any additional wound The property made is worked.
It is preferred that the analyte monitoring provided according to another aspect of the present invention and automatic chemical feeding system, are further wrapped Include：Substrate, substrate is formed by flexible material；Also, each working electrode and each reference electrode in detection unit are respectively formed The acicular member of a side surface of substrate is attached to for one end, and the other end of each working electrode and each reference electrode is formed For tip；Each injection member in injecting unit be formed as one end attach to substrate it is a side surface, be internally formed stream The acicular member of body passage, and the other end of each injection member is formed as tip.
Further, the analyte monitoring and automatic chemical feeding system provided according to presently preferred embodiments of the present invention, enters one Step includes：Substrate 14, the substrate 14 can be formed by flexible material.More specifically, each detection part 11 in detection unit 1 It may be contained within a side surface of substrate 14.More specifically, each working electrode 12 and each reference electrode in detection unit 1 13 are all formed as the acicular member that one end attaches to a side surface of substrate 14；Also, each working electrode 12 and each reference The other end of electrode 13 is formed as tip.In addition, in the present invention, each injection member 41 in injecting unit 4 is again formed as One end attaches to an acicular member side surface, being internally formed fluid passage of substrate 14.Also, each injection member 41 other end is formed as tip, and when injection member 41 inserts patient skin, medicine is by medicine distribution circuit 43 by drug storage The fluid passage that part is flowed into inside each injection member 41, and flowed into patient body by the tip of each injection member 41. That is, in the analyte monitoring and automatic chemical feeding system provided according to presently preferred embodiments of the present invention, detection part 11 are respectively formed the same side surface for being arranged at substrate 14 (that is, in a state of use towards the one of human body surface with injection member 41 Side surface), for example, for the ease of manufacturing and controlling, as shown in rear attached Figure of description, detection part 11 is both formed in substrate 14 A side surface a side, and injection member 41 is formed at the opposing party of a side surface of substrate 14.For example, rear attached explanation Shown in book accompanying drawing 2b, detection part 11 is both formed in the right of a side surface of substrate 14, and injection member 41 is both formed in base The left of one side surface of piece 14.
More specifically, in the preferred embodiment, substrate 14 is flexible, to reduce implantation and/or wear The pain brought when the detection part 11 is with injection member 41 to patient and the damage to tissue.Flexible substrate 14 generally increases The comfort level of patient simultaneously allows patient to have bigger scope of activities.Suitable material for flexible substrate 14 includes for example non-lead The material of electric plastics or polymer and other non-conductive, flexible, deformable materials.Useful plastics or the reality of polymeric material Example include thermoplastic, such as makrolon, poly terephthalic acid diethyl alcohol ester (PET)), polyvinyl chloride (PVC), poly- ammonia Ester, polyethers, polyamide, polyimides, or these thermoplastics copolymer, such as PETG (ethylene glycol modification it is poly- to benzene Dicarboxylic alcohol ester).
Further, according to actual use and design needs, according to the analyte monitoring of the present invention and automatic chemical feeding system In substrate 14 can also be rigid.It can be that detection part 11 and injection member 41 provide structure to use rigid substrate 14 Support, with counter-bending or rupture.More specifically, may be used as the example of the rigid material of substrate 14 includes the pottery of poorly conductive Porcelain, such as aluminum oxide and silica.It is to contribute to detection part 11 and injection using another advantage of rigid substrate 14 Part 41 is inserted into the case where that need not be additionally inserted into device.
Further, as shown in rear attached Figure of description 2a and Fig. 2 b, according to analyte monitoring provided by the present invention with The substrate 14 of automatic chemical feeding system is additionally provided with electric connection 15, and the electric connection 15 is connected with external power source, so as to be detection part Working electrode 12 and reference electrode 13 in 11 are powered, to carry out electric oxygen to analyte using working electrode 12 and reference electrode 13 Change or electro-reduction reaction.
When using the analyte monitoring according to presently preferred embodiments of the present invention with automatic chemical feeding system, user will be set The predetermined position of human body surface is inserted in the detection part 11 on substrate 14 and injection member 41, not only causes each detection part 11 working electrode 12 and reference electrode 13 is located at the analyte of the liquid (such as body fluid, sample liquid or carrier fluid) of analyte-containing In (such as glucose, oxygen, triglycerides or ketoboidies), to be monitored to analyte, and cause each injection member 41 In vein or position comprising body fluid, in order to by infusion of medicine human body.Further, for example, detection part 11 and injection The implantation of part 41 can be carried out in venous system, for the analyte level in directly test blood, and directly by medicine Thing is expelled in blood.Or, detection part 11 can be implanted in interstitial tissue, for determining the analyte in interstitial fluid Analyte level in level, interstitial fluid can associate and/or be converted into the analyte level in blood or other liquid.Together When, injection member 41 is implanted in interstitial tissue, is used for injecting medication into interstitial fluid.In this case, test section Part 11 can influence the concrete shape of detection part 11 and injection member 41, part with the position of the implantation of injection member 41 and depth And structure.
Further, according to presently preferred embodiments of the present invention, detection part 11 and injection member on substrate 14 are arranged at In the interstitial tissue of 41 insertion patients (between 0.3mm to 5mm).Preferably, it is inserted into interstitial tissue, 0.5mm to 3mm, More preferably 0.5mm to 1.5mm.The other embodiment of the present invention may include the other parts for being inserted into patient, for example vein or The detection part 11 and injection member 41 of organ.The depth of implantation becomes according to the target to be implanted into.Further, it is possible in substrate 14 be provided with the surface of detection part 11 coats stickum, so that in detection part 11 and the insertion patient of injection member 41 Epidermis after, by the stickum on the surface of substrate 14, detection part 11 and injection member 41 are fixed in patient body, Consequently facilitating patient monitoring analyte level interior for a period of time and to patient carry out drug injection, without every time measurement all Reinsert detection part 11 and injection member 41.
Further, measure insertion angle from skin surface and (that is, insert the insertion that sensor should be 90 ° perpendicular to skin Angle).Insert angle generally 10 ° to 90 °, typically at 15 ° to 60 °, more often in 30 ° to 45 ° in the range of.
Have a structure in which, patient is when using analyte monitoring provided by the present invention with automatic chemical feeding system, energy The pain of patient is enough reduced to a great extent.Further, alternatively, will according to analyte monitoring provided by the present invention with Substrate 14, detection part 11 and injection member 41 in automatic chemical feeding system, which are made, makes the shape of patient comfort, and it can allow Below the clothes for being hidden in such as patient.For patient, thigh, leg, upper arm, shoulder or belly are on patient body For placing detection part 11, the eaily position to remain hidden.However, detection part 11 and injection member 41 also may be used To be placed on other positions of patient body.
In addition, to those skilled in the art, can be according to specifically used and design needs, for many test sections For part 11 and injection member 41, rigid and flexible substrate can be suitably used, can also be for example, by changing base The composition and/or thickness of piece 14 are flexible continuously to change it.These can be by those skilled in the art according to specifically used With design it needs to be determined that.
More specifically, the analyte monitoring and automatic chemical feeding system provided according to presently preferred embodiments of the present invention, often The size of individual detection part 11 and injection member 41 is significantly smaller than common syringe needle, so as to be carried using the present invention When the detection part 11 of confession carries out the monitoring of analyte and carries out drug injection using injection member 41, the pain of patient can be big It is big to reduce, and because the skin of detection part 11 and injection member 41 is pierced into depth very little, wound infection will not be caused, also not Meeting scar due to long periods of wear.
Further, the analyte monitoring provided according to another aspect of the present invention and automatic chemical feeding system, wherein：Calculate Unit 3 is according to content of triglyceride, blood sugar monitoring value and recent change of blood sugar trend in the body weight of patient, waist-to-hipratio, blood Calculate total injection volume of medicine.
More specifically, the analyte monitoring provided according to the preferred embodiment of the present invention and automatic chemical feeding system System, wherein：Computing unit 3 monitors equal according to content of triglyceride, odd-numbered day preprandial glucose in the body weight of patient, waist-to-hipratio, blood Value and three days in change of blood sugar trend calculate medicine total injection volume.And：
Computing unit 3 calculates total injection volume of medicine according to below equation：
Wherein：
L1：Patient's odd-numbered day total injection volume (u) of medicine before the meal that computing unit 3 is calculated；
K：Inject the body weight (Kg) of object；
Y：Inject the waist-to-hipratio of object；
X：Triglycerides (mmol/L) content in the blood of object is injected, wherein：
When content of triglyceride is below 1.7：X=1；
Content of triglyceride is more than 1.7 and when below 2.5：X=1.1；
Content of triglyceride is more than 2.5 and when below 5：X=1.2；
Content of triglyceride is more than 5 and when below 10：X=1.3；
When content of triglyceride is more than 2.5 and is less than 5：X=1.4；
A：Inject odd-numbered day preprandial glucose (mmol/L) average of object；
a：Preprandial glucose variation tendency in three days of object is injected, wherein：
When preprandial glucose change is overall when within ± the 5% of initial measurement in three days of injection object：A=1；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is compared to ascending amount when within 10%：A=1.1；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is more than 10% and when within 20% compared to ascending amount：A=1.2；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is more than 20% and when within 30% compared to ascending amount：A=1.3；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is more than 30% and when within 40% compared to ascending amount：A=1.4；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum When value is more than 40% compared to ascending amount：A=1.5；And
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is compared to slippage when within 10%：A=0.9；
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is more than 10% and when within 20% compared to slippage：A=0.8；
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is more than 20% and when within 30% compared to slippage：A=0.7；
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is compared to slippage when within 40%：A=0.6.
More specifically, the present inventor is by a large amount of multiple repairing welds, to the injection of insulin of 20 typical patients Amount has carried out checking and calculated, and specific data form is as shown in table 1 below：
Table 1
According to above table as can be seen that according to computational methods provided by the present invention, each patient can be directed to each Different physical conditions, accurately calculates the insulin injection amount of patient before the meal, so as to make the treatment of personalization.More have Body, according to analyte monitoring provided by the present invention and automatic chemical feeding system, according in the body weight of patient, waist-to-hipratio, blood Content of triglyceride, odd-numbered day preprandial glucose monitoring average and preprandial glucose variation tendency in three days, are calculated by computing unit 3 The odd-numbered day of insulin injects total amount L before the meal1, and injected by injecting unit 4 before the meal, so as to made to each patient Specific aim, personalized treatment.
Further, the analyte monitoring and automatic chemical feeding system provided according to the another embodiment of the present invention In：Computing unit 3 monitors average, list according to content of triglyceride, odd-numbered day preprandial glucose in the body weight of patient, waist-to-hipratio, blood Day postprandial blood sugar monitoring average and change of blood sugar trend calculates total injection volume of medicine in three days；And
Computing unit calculates total injection volume of medicine according to below equation：
Wherein：
L2：The total injection volume (u) of patient's odd-numbered day medicine that computing unit 3 is calculated；
K：Inject the body weight (Kg) of object；
Y：Inject the waist-to-hipratio of object；
X：Triglycerides (mmol/L) content in the blood of object is injected, wherein：
When content of triglyceride is below 1.7：X=1；
Content of triglyceride is more than 1.7 and when below 2.5：X=1.1；
Content of triglyceride is more than 2.5 and when below 5：X=1.2；
Content of triglyceride is more than 5 and when below 10：X=1.3；
When content of triglyceride is more than 2.5 and is less than 5：X=1.4；
A：Inject odd-numbered day preprandial glucose (mmol/L) average of object；
a：Preprandial glucose variation tendency in three days of object is injected, wherein：
When preprandial glucose change is overall when within ± the 5% of initial measurement in three days of injection object：A=1；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is compared to ascending amount when within 10%：A=1.1；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is more than 10% and when within 20% compared to ascending amount：A=1.2；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is more than 20% and when within 30% compared to ascending amount：A=1.3；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is more than 30% and when within 40% compared to ascending amount：A=1.4；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum When value is more than 40% compared to ascending amount：A=1.5；And
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is compared to slippage when within 10%：A=0.9；
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is more than 10% and when within 20% compared to slippage：A=0.8；
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is more than 20% and when within 30% compared to slippage：A=0.7；
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is compared to slippage when within 40%：A=0.6；And
B：Inject odd-numbered day postprandial blood sugar (mmol/L) average of object；
b：Postprandial blood sugar variation tendency in three days of object is injected, wherein：
When postprandial blood sugar change is overall when within ± the 5% of initial measurement in three days of injection object：A=1；
When postprandial blood sugar change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is compared to ascending amount when within 10%：A=1.1；
When postprandial blood sugar change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is more than 10% and when within 20% compared to ascending amount：A=1.2；
When postprandial blood sugar change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is more than 20% and when within 30% compared to ascending amount：A=1.3；
When postprandial blood sugar change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum Value is more than 30% and when within 40% compared to ascending amount：A=1.4；
When postprandial blood sugar change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose are minimum When value is more than 40% compared to ascending amount：A=1.5；And
When postprandial blood sugar change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is compared to slippage when within 10%：A=0.9；
When postprandial blood sugar change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is more than 10% and when within 20% compared to slippage：A=0.8；
When postprandial blood sugar change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is more than 20% and when within 30% compared to slippage：A=0.7；
When postprandial blood sugar change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose are maximum Value is compared to slippage when within 40%：A=0.6；And
The drug injection amount L of odd-numbered day before the meal21=L2×0.6；The drug injection amount L of odd-numbered day after the meal22=L2×0.4。
More specifically, insulin injection amount of the present inventor to 20 typical patients listed in upper table 1 Carry out checking to calculate, specific data form is as shown in table 2 below：
Table 2
According to above table as can be seen that according to injection of insulin total amount computational methods provided by the present invention, Neng Gouzhen To the respective different physical condition of each patient, odd-numbered day medicine (insulin) the injection total amount of patient is accurately calculated.More enter one Step, the patient's odd-numbered day injection of insulin total amount obtained according to the calculating further obtains odd-numbered day of patient pancreas before the meal by calculating Island element injection volume L21, and the insulin injection amount L of odd-numbered day after the meal22.More specifically, according to pancreas islet provided by the present invention Element injection total amount computational methods, the patient that insulin twice is injected for daily requirement, early drug injection amount L before the meal21=L2 ×0.6；Early drug injection amount L before the meal22=L2×0.4。
More specifically, according to analyte monitoring provided by the present invention and automatic chemical feeding system, the body weight of foundation patient, Content of triglyceride, odd-numbered day preprandial glucose monitoring average, odd-numbered day postprandial blood sugar monitoring average and three days in waist-to-hipratio, blood Interior change of blood sugar trend, the odd-numbered day injection total amount L of the insulin of each patient is precisely calculated by computing unit 32, and Thus breakfast prodrug injection volume L of patient is obtained21With breakfast prodrug injection volume L22, and further by injecting unit 4 in morning Before the meal with accurately injected respectively before dinner, so as to make targeted, personalized treatment to each patient.
That is, according to analyte monitoring provided by the present invention and automatic chemical feeding system, injecting unit 4 can basis The result of calculation of computing unit 3, for each patient particular case of itself, is early carrying out accurately determining before the meal and/or before dinner The drug injection of amount, so that treatment targetedly, personalized is made to each patient, compared to existing injection of insulin Device, can carry out injection of insulin, so as to avoid because dosage is not enough according to patient's own characteristic with accurately numerical value Or dosage excessively and to patient produces uncomfortable influence.Further, because injecting unit 4 includes at least two injection parts Part 41, carries out drug injection by least two injection member 41, can effectively increase drug injection area simultaneously, hence it is evident that Improve callosity, and effectively strengthen drug absorption effect, lift therapeutic effect.Further, according to the excellent of the present invention Select embodiment, injecting unit 4 includes the multiple injection members 41 arranged in the form of an array, medicine is increased so as to maximally efficient Thing injects area, improves callosity, strengthens drug absorption effect.Further, can be by according to the injection member 41 of the present invention Dimethyl siloxane (PDMS) or other similar materials are made, and various corrosion-resistant coatings can be coated by playing surface, to play sealedly Effect.
More specifically, the analyte monitoring and automatic chemical feeding system provided according to present pre-ferred embodiments, passes through Detection unit 1, processing unit 2 and computing unit 3 can be according to actual needs to the health of user (for example, glucose Content, ketoboidies content, oxygen content etc.) it is monitored, and obtain corresponding expression health by calculating by computing unit 3 Result of calculation (for example, odd-numbered day blood glucose mean, change of blood sugar trend etc. in three days)；Further, computing unit 3 is according to the expression body The result of calculation of body situation, with reference to some other personal information of patient (for example, triglycerides in body weight, waist-to-hipratio and blood Content etc.), patient's odd-numbered day pre-meal insulin injection total amount and/or patient's odd-numbered day injection of insulin total amount are obtained by calculating, and Further injecting unit 4 is controlled by control unit 5, to carry out accurate, quantitative injection of insulin, so as to avoid Because dosage is not enough or dosage is excessive and uncomfortable influence is produced to patient.In addition, according to provided by the present invention point Thing monitoring and automatic chemical feeding system are analysed, accurate relevant patient body shape can be obtained by the simple structure of detection unit 1 The monitoring numerical value of condition, and drug injection area can effectively be increased, hence it is evident that change by the simple structure of injecting unit 4 Kind callosity, and effectively strengthen drug absorption effect, lift therapeutic effect.
It is preferred that in the analyte monitoring and automatic chemical feeding system that are provided according to presently preferred embodiments of the present invention：Each work The outer surface for making electrode 12 is additionally provided with electro transfer layer.More specifically, in the present invention, each working electrode 12 is outer Working surface is provided with perimeter surface, the working surface is a part for the outer surface of working electrode, its above be coated with or There can be electron transfer agent, and the working surface is configured to be exposed to a kind of liquid of analyte-containing.Further, in this hair In bright, " electron transfer agent " is can be directly or with other electron transfer agents ordinatedly between analyte and working electrode 12 The compound of electronics is carried, wherein, an example of electron transfer agent is redox medium.
Specifically, some analytes (such as oxygen) can be on working electrode 12 by Electrocatalytic Oxidation or electroreduction.Its He needs the presence of at least one electron transfer agent and/or at least one catalyst at analyte (such as glucose and lactose), with Beneficial to the electroxidation or electroreduction of analyte.For can directly on working electrode 12 electroxidation or the analyte of electroreduction (such as oxygen), can also use catalyst.These analytes for needing electron transfer agent and/or catalyst, each work Electrode 12 has the electron transfer agent and/or catalyst formed on the working surface of working electrode 12 or near it.Typically, Working surface is only in the sub-fraction of working electrode 12 or near it, the tip formation often close to working electrode 12, And working surface is placed in the optimum position of the liquid (such as body fluid, sample liquid or carrier fluid) of contact analyte-containing.More have Body, electron transfer agent and/or catalyst can be formed as the solid composite positioned at working surface.These compositions are preferably It will not leach, be more preferably fixed on working electrode 12 from working electrode 12.For example, these compositions can be fixed on into work Make on surface.Alternatively, electron transfer agent and/or catalyst can be fixed in working surface, or are fixed on and are deposited to Between one or more films or film on working surface, or these compositions can be fixed on polymer or sol-gel base In matter.More specifically, the working surface of working electrode 12, which can be included, is used for the reaction of catalytic analysis thing and in working electrode The catalyst (such as glucose oxidase, lactose oxidase or laccase) of reactant is produced at 12 and/or in analyte and Between working electrode 12 directly or indirectly (or both) transfer electronics electron transfer agent (for example, respectively be beneficial to glucose, lactose Or the electron transfer agent of the electroxidation of oxygen).
Further, the analyte monitoring provided according to another aspect of the present invention and automatic chemical feeding system, Mei Gejian The working electrode 12 surveyed in part 11 is formed from reference electrode 13 by different materials.More specifically, in the preferable of the present invention In embodiment, working electrode 12 and reference electrode 13 in each detection part use two distinct types of conductive material (for example, carbon and silver/silver chlorate) formation electrode, has a structure in which, more accurately can carry out electroxidation to analyte Or electro-reduction reaction, so as to obtain accurate result.Further, in the preferred embodiment, a type of conduction Materials application is to the side of substrate 14, so as to reduce the step in manufacturing process and/or the limit being aligned easily against during System.If for example, form the working electrode 12 of each detection part 11 using carbon-based conductive material, and all working electrode 12 Positioned at the side of substrate 14；Further, the reference electrode 13 of each detection part 11 is formed using silver/silver chlorate conductive material, All reference electrodes 13 are located at the opposite side of substrate 14.Therefore, can be in the opposite sides of substrate 14 in order to easily manufactured The working electrode 12 and reference electrode 13 of array arrangement are formed respectively.
Further, the analyte monitoring provided according to another aspect of the present invention and automatic chemical feeding system, further Including：Personal information can be inputted analyte monitoring and automatic chemical feeding system by input block 6, user by input block 6. More specifically, user can be by input block 6 by content of triglyceride, blood glucose in the waist-to-hipratio of oneself, body weight, blood The personal information such as monitoring numerical value input analyte monitoring and automatic chemical feeding system, and then computing unit 3 is inputted according to user Personal information, calculated according to injection of insulin total amount computational methods provided by the present invention, so as to obtain and personal information Corresponding injection of insulin total amount, and and then injected by injecting unit 4.Or, user will by input block 6 Personal information (for example, content of triglyceride in waist-to-hipratio, the body weight, blood) input of oneself, and pass through with reference to computing unit 3 Calculate and obtain the corresponding result of calculation (for example, odd-numbered day blood glucose mean, change of blood sugar trend etc. in three days) for representing health, Calculated by computing unit 3 according to injection of insulin total amount computational methods provided by the present invention, so as to obtain and personal letter The corresponding injection of insulin total amount of manner of breathing, and and then injected by injecting unit 4.
Further, according to analyte monitoring provided by the present invention and automatic chemical feeding system, setup unit is further comprised 7, user can be set by the setup unit 7 to analyte monitoring provided by the present invention with automatic chemical feeding system. More specifically, user can be entered by setup unit 7 to analyte monitoring provided by the present invention with automatic chemical feeding system Row setting, for example, by the use condition of 7 pairs of analyte monitorings of the setup unit and automatic chemical feeding system (for example, to analysis Time cycle, time interval that thing is monitored etc.) set, or, user can also should by 7 pairs of the setup unit Analyte monitoring and the use state (for example, the meal time of patient, switching on and shutting down time etc.) of automatic chemical feeding system are set, And user can also be set by 7 pairs of analyte monitorings of the setup unit and display mode of automatic chemical feeding system etc. It is fixed, in order to user's being actually needed using the analyte monitoring and automatic chemical feeding system according to oneself.Further, according to this The analyte monitoring provided and automatic chemical feeding system are invented, setup unit 7 is electrically connected with control unit 5, so that user passes through The various settings to analyte monitoring and automatic chemical feeding system that setup unit 7 is made can be by control unit 5 to other Unit is controlled.
Further, the analyte monitoring and automatic chemical feeding system, input block 6 and setup unit provided according to the present invention 7 electrically connect with control unit 5 respectively, so as to be controlled by control unit 5 to input block 6 with setup unit 7, while defeated Other units can also be fed back to by control unit 5 by entering the various feedbacks of unit 6 and setup unit 7.
Further, the analyte monitoring provided according to a preferred embodiment of the invention and automatic chemical feeding system, are further wrapped Include：Comparing unit 8, the place corresponding with the testing result of each detection part 11 that the comparing unit 8 is obtained to processing unit 2 Reason numerical value is compared one by one respectively, and the fiducial value obtained more afterwards one by one is carried out respectively with monitoring threshold set in advance Compare, to obtain monitoring fiducial value.More specifically, as described above, in point provided according to a preferred embodiment of the invention Analyse thing monitoring and in automatic chemical feeding system, the testing result of each detection part 11 of 2 pairs of processing unit is analyzed and processed, so that Obtain the processing numerical value corresponding with the testing result of each detection part 11.That is, at least two detection parts 11, processing unit 2, which will be obtained, accordingly obtains at least two processing numerical value.Further, analyte provided by the present invention is passed through Monitoring and the comparing unit 8 of automatic chemical feeding system, at least two processing numerical value obtained to processing unit 2 are compared one by one, So as to obtain at least one monitoring fiducial value, the monitoring fiducial value can be two processing numerical value be compared after difference or Ratio.Further, comparing unit 8 is compared again at least one monitoring fiducial value with monitoring threshold set in advance, The monitoring threshold set in advance can be the specific threshold that producer is set in advance in comparing unit 8 or control unit 5, Can also be user according to specific using the threshold value for needing to set by setup unit 7, this can according to actual design and Using it needs to be determined that.Further, prompting is also included according to analyte monitoring provided by the present invention and automatic chemical feeding system single Member 9, if be compared by comparing unit 8 at least one monitoring fiducial value with monitoring threshold set in advance, wherein having At least one monitoring fiducial value is more than monitoring threshold set in advance, and the Tip element 9 sends cue.More specifically, The Tip element 9 can be pointed out using sound and/or light, and the Tip element 9 can be sound-generating element or luminous component, or Both combinations.By such structure, analyte monitoring and automatic chemical feeding system can be easily obtained, is especially detected The work running situation of unit 1.More specifically, should if exception occurs in some detection part 11 in detection unit 1 There is exception, and then the abnormality detection compared with the testing result of other detection parts 11 of surrounding in the testing result of detection part 11 Also necessarily there is abnormality processing numerical value after being handled through processing unit 2 in the abnormality detection result of part 11, and further by comparing The monitoring fiducial value that the processing numerical value corresponding with other detection parts 11 of unit 8 is compared acquisition will be greater than prison set in advance Survey threshold value.In this case, Tip element 9 sends prompting, notifies some detection part in user's detection unit 1 11 there is operation irregularity, so as to stop monitoring in time and change detection part 11 or detection unit 1.
Further, the analyte monitoring provided according to presently preferred embodiments of the present invention is with automatic chemical feeding system, comparing Unit 8 can also calculate computing unit 3 obtained insulin injection amount (that is, L as described above1Or L2) with it is set in advance Medication threshold value is compared, and when computing unit 3 calculates obtained insulin injection amount (that is, insulin injection amount) less than pre- During the medication threshold value first set, prompting is sent to user by Tip element 9.More specifically, for example, according to the present invention's Preferred embodiment, medication threshold value set in advance can also be stored in control unit 5 or comparing unit 8, and the medication Threshold value (can correspond to computing unit 2 and calculate obtained L for 5u1) or the 10u (L obtained corresponding to the calculating of computing unit 32), If the insulin injection amount that the calculating of computing unit 3 is obtained is less than medication threshold value set in advance, (that is, computing unit 2 is calculated The L arrived1Less than 5u；Or, computing unit 2 calculates obtained L2Less than 10u), then Tip element 9 sends prompting to user, Prompting user can select not insulin injection in this case, and be waited just by oral drugs such as keep on a diet Formula carries out the control of internal blood glucose.More specifically, the Tip element 9 can include making user by lamp or sound The part of prompting, for example, sound-generating element or luminous component.
Further, the analyte monitoring and automatic chemical feeding system, comparing unit 8 and Tip element provided according to the present invention 9 electrically connect with control unit 5 respectively, so that comparing unit 8 and Tip element 9 are controlled by control unit 5, while than Various feedbacks compared with unit 8 and Tip element 9 can also feed back to other units by control unit 5.
Further, to those skilled in the art, Tip element 9 can send different carry in varied situations Show signal.For example, when monitoring fiducial value more than monitoring threshold, Tip element 9 is made to user by way of luminous and carried Show；And when medication fiducial value is less than medication threshold value, Tip element 9 makes prompting by way of sounding to user.And or Person, Tip element 9 can send the prompting light of different colours (for example, when monitoring fiducial value is more than monitoring threshold in varied situations During value, Tip element 9 makes prompting by way of glowing to user；And when medication fiducial value is less than medication threshold value, Tip element 9 makes prompting by way of the light (for example, gold-tinted or green glow) for sending out other colors to user) or it is different The voice prompt of effect, consequently facilitating user distinguishes different situations.
Further, the analyte monitoring provided according to a preferred embodiment of the invention and automatic chemical feeding system, are further wrapped Include：Display unit 10, the display unit 10 is used for the result of calculation for showing computing unit 3.More specifically, as described above, root In the analyte monitoring and automatic chemical feeding system that are provided according to the preferred embodiments of the present invention, 3 pairs of computing unit is detected with each The corresponding processing numerical value of part 11 is compared calculating, so that accurate result of calculation is obtained, and the result of calculation exactly can Enough reflect the numerical value of patient analyte level.Further, the result of calculation of the computing unit 3 is shown by display unit 10 Come, thus patient can it is directly perceived by display unit 8, its analyte level is seen immediately, so as to understand condition.Enter one Step, computing unit 3 is calculated always according to the personal information of patient, to obtain the insulin injection amount for individual patient.Enter One step, is shown the result of calculation of the computing unit 3 by display unit 10, so that patient can pass through display unit 10 Intuitively, the result of calculation of computing unit 3 is seen immediately, so that knowing will inject into internal medicine total amount, understands disease Therapeutic state.In addition, the display unit 10 can also show sweet in such as body weight, blood that patient is inputted by input block 6 The personal information such as oily three ester contents, blood sugar monitoring numerical value, so as to understand the health of itself.
Further, analyte monitoring provided by the present invention also includes storage element 11, the storage with automatic chemical feeding system Unit 11 is stored to the result of calculation of computing unit 3.More specifically, the storage element 11 could be arranged to storage one Multiple result of calculations of computing unit 3 in time cycle (for example, 72 hours or longer time), consequently facilitating user from The result of calculation in the time cycle is extracted and analyzed in the storage element 11, and and then obtains medicine in the time cycle The service condition of thing, and own bodies state change, and further make various adjustment.
Further, the analyte monitoring and automatic chemical feeding system provided according to the present invention, display unit 10 is single with storage Member 11 is electrically connected with control unit 5 respectively, so that display unit 10 is controlled with storage element 11 by control unit 5, The various feedbacks of display unit 10 and storage element 11 can also feed back to other units by control unit 5 simultaneously.
Further, the analyte monitoring provided according to another aspect of the present invention and automatic chemical feeding system, further Including：Transmitter unit 12, the transmitter unit 12 is stored in the result of calculation and/or storage element 11 for sending computing unit 3 Result of calculation.More specifically, according to presently preferred embodiments of the present invention, transmitter unit 12 can be by wired (for example, data Transmission line) or wireless (for example, wireless network, Bluetooth transmission etc.) mode be sent out computing unit 3 result of calculation and/or The result of calculation stored in storage element 11.So that user can obtain for example, by wire/wireless handheld device calculates single The result of calculation stored in the result of calculation and/or storage element 11 of member 3.Further, if installed in the mobile phone of user With the application software (mobile phone A pp) of analyte monitoring provided by the present invention and automatic chemical feeding system adaptation, can by with The transmitter unit 12 matches (for example, Bluetooth pairing, wireless network are with equity), calculates single so as to easily be obtained on mobile phone The result of calculation stored in the result of calculation and/or storage element 11 of member 3, grasps the condition of patient at any time.In addition, for For medical institutions, can also by the way that multiple analyte monitorings and automatic chemical feeding system are included into same wireless network so that The condition and treatment situation of multiple patients can in real time be monitored, and can be occurred in the condition of patient abnormal When give a warning immediately.
It is preferred that according to analyte monitoring provided by the present invention and automatic chemical feeding system：Processing unit 2, computing unit 3rd, input block 6, setup unit 7, comparing unit 8, Tip element 9, display unit 10, storage element 11, transmitter unit 12 with And control unit 5 is packaged in same housing.It is highly preferred that in the preferred embodiment, included by injecting unit 4 Drug storage part (not shown) and syringe pump (not shown) can also be included in the same housing, and pass through medicine distribution circuit It is in fluid communication with injection member 41.Further, in the preferred embodiment, the housing is at least waterproof, to avoid Liquid is flowed into and contacted with the element in housing.In some embodiments, housing be formed as sealedly, waterproof or resistance to watertight Envelope, so that liquid cannot flow into the enclosure interior, this is when user such as take a shower, have a bath or swim such activity It is highly useful.In addition, the shape of housing can be according to actual design and using needing to carry out any selection, for example, the housing can To be formed as section as circular, ellipse or other are variously-shaped, as long as adapting to the body use of user.
Further, need herein, a kind for the treatment of disease (sugar is merely illustrated in presently preferred embodiments of the present invention Urine disease) monitoring and medicine (insulin) injecting systems.But, to those skilled in the art, it is easy to it is contemplated that Analyte monitoring provided by the present invention can be used in the drug injection of various diseases with automatic chemical feeding system, for example, can use In the injection of the medicines such as control patient's high fat of blood, hypertension, this can arbitrarily be selected according to actual needs, and this simultaneously need not Any additional creative work.
The above-described embodiments merely illustrate the principles and effects of the present invention, not for the limitation present invention.It is any ripe Know the personage of this technology all can carry out modifications and changes under the spirit and scope without prejudice to the present invention to above-described embodiment.Cause This, those of ordinary skill in the art is complete without departing from disclosed spirit and institute under technological thought such as Into all equivalent modifications or change, should by the present invention claim be covered.

Claims (13)

1. a kind of analyte monitoring and automatic chemical feeding system, it is characterised in that including：
Detection unit, the detection unit includes at least two detection parts, and each detection part is used to detection and analysis Analysis object in thing；
Processing unit, the processing unit is analyzed and processed to the testing result of each detection part, with acquisition and often The corresponding processing numerical value of the testing result of individual detection part；
Computing unit, the computing unit pair processing numerical value corresponding with each detection part is compared calculating, with At-once monitor result is obtained, also, the computing unit is additionally operable to calculate total injection volume of the medicine；With
Injecting unit, total injection volume that the injecting unit calculates the obtained medicine according to the computing unit injects medicine Thing, and the injecting unit includes at least two injection members, wherein each injection member is used to inject medicine；
Control unit, described control unit controls the detection unit, the processing unit, the computing unit and the injection Unit.
2. analyte monitoring as claimed in claim 1 and automatic chemical feeding system, it is characterised in that wherein：
The computing unit is according to content of triglyceride, blood sugar monitoring value and recent blood in the body weight of patient, waist-to-hipratio, blood Sugared variation tendency calculates total injection volume of the medicine.
3. analyte monitoring as claimed in claim 2 and automatic chemical feeding system, it is characterised in that：
Each detection part is electrochemical sensor, including working electrode and reference electrode；
The processing unit is by the electric signal between the working electrode and the reference electrode in each detection part Analyzed and processed, so as to obtain corresponding analysis result corresponding to each detection part；And
The injecting unit also includes drug storage part, medicine distribution circuit and syringe pump；Wherein
The total injection volume for the medicine that described control unit is calculated according to the computing unit, is controlled to the syringe pump System, the injection part is sent to by the medicine in the drug storage part according to required amount by the medicine distribution circuit Part.
4. analyte monitoring as claimed in claim 3 and automatic chemical feeding system, it is characterised in that further comprise：
Substrate, the substrate is formed by flexible material；And
Each working electrode and each reference electrode in the detection unit are all formed as one end attaches to the substrate one The acicular member of side surface, and the other end of each working electrode and each reference electrode is formed as tip；
Each injection member in the injecting unit be formed as one end attach to the substrate it is a side surface, The acicular member of fluid passage is internally formed, and the other end of each injection member is formed as tip.
5. analyte monitoring as claimed in claim 4 and automatic chemical feeding system, it is characterised in that wherein：
The computing unit is according to content of triglyceride, preprandial glucose monitor value and three in the body weight of patient, waist-to-hipratio, blood In a few days change of blood sugar trend calculates total injection volume of the medicine；And
The computing unit calculates total injection volume of the medicine according to below equation：
L 1 = 1 12 K · Y × X × A a
Wherein：
L1：The total injection volume (u) for the medicine that the computing unit is calculated；
K：Inject the body weight (Kg) of object；
Y：Inject the waist-to-hipratio of object；
X：Triglycerides (mmol/L) content in the blood of object is injected, wherein：
When content of triglyceride is below 1.7：X=1；
Content of triglyceride is more than 1.7 and when below 2.5：X=1.1；
Content of triglyceride is more than 2.5 and when below 5：X=1.2；
Content of triglyceride is more than 5 and when below 10：X=1.3；
When content of triglyceride is more than 2.5 and is less than 5：X=1.4；
A：Inject odd-numbered day preprandial glucose (mmol/L) average of object；
a：Preprandial glucose variation tendency in three days of object is injected, wherein：
When preprandial glucose change is overall when within ± the 5% of initial measurement in three days of injection object：A=1；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose minimum value phase Than ascending amount when within 10%：A=1.1；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose minimum value phase It is more than 10% and when within 20% than ascending amount：A=1.2；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose minimum value phase It is more than 20% and when within 30% than ascending amount：A=1.3；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose minimum value phase It is more than 30% and when within 40% than ascending amount：A=1.4；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose minimum value phase When being more than 40% than ascending amount：A=1.5；And
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose maximum phase Than slippage when within 10%：A=0.9；
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose maximum phase It is more than 10% and when within 20% than slippage：A=0.8；
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose maximum phase It is more than 20% and when within 30% than slippage：A=0.7；
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose maximum phase Than slippage when within 40%：A=0.6.
6. analyte monitoring as claimed in claim 4 and automatic chemical feeding system, it is characterised in that wherein：
The computing unit is according to content of triglyceride in the body weight of patient, waist-to-hipratio, blood, preprandial glucose monitor value, after the meal Blood sugar monitoring value and change of blood sugar trend calculates total injection volume of the medicine in three days；And
The computing unit calculates total injection volume of the medicine according to below equation：
L 2 = 1 5 K · Y × X × ( A a + B b 2 )
Wherein：
L2：The total injection volume (u) for the medicine that the computing unit is calculated；
K：Inject the body weight (Kg) of object；
Y：Inject the waist-to-hipratio of object；
X：Triglycerides (mmol/L) content in the blood of object is injected, wherein：
When content of triglyceride is below 1.7：X=1；
Content of triglyceride is more than 1.7 and when below 2.5：X=1.1；
Content of triglyceride is more than 2.5 and when below 5：X=1.2；
Content of triglyceride is more than 5 and when below 10：X=1.3；
When content of triglyceride is more than 2.5 and is less than 5：X=1.4；
A：Inject odd-numbered day preprandial glucose (mmol/L) average of object；
a：Preprandial glucose variation tendency in three days of object is injected, wherein：
When preprandial glucose change is overall when within ± the 5% of initial measurement in three days of injection object：A=1；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose minimum value phase Than ascending amount when within 10%：A=1.1；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose minimum value phase It is more than 10% and when within 20% than ascending amount：A=1.2；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose minimum value phase It is more than 20% and when within 30% than ascending amount：A=1.3；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose minimum value phase It is more than 30% and when within 40% than ascending amount：A=1.4；
When preprandial glucose change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose minimum value phase When being more than 40% than ascending amount：A=1.5；And
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose maximum phase Than slippage when within 10%：A=0.9；
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose maximum phase It is more than 10% and when within 20% than slippage：A=0.8；
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose maximum phase It is more than 20% and when within 30% than slippage：A=0.7；
When preprandial glucose change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose maximum phase Than slippage when within 40%：A=0.6；And
B：Inject odd-numbered day postprandial blood sugar (mmol/L) average of object；
b：Postprandial blood sugar variation tendency in three days of object is injected, wherein：
When postprandial blood sugar change is overall when within ± the 5% of initial measurement in three days of injection object：A=1；
When postprandial blood sugar change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose minimum value phase Than ascending amount when within 10%：A=1.1；
When postprandial blood sugar change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose minimum value phase It is more than 10% and when within 20% than ascending amount：A=1.2；
When postprandial blood sugar change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose minimum value phase It is more than 20% and when within 30% than ascending amount：A=1.3；
When postprandial blood sugar change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose minimum value phase It is more than 30% and when within 40% than ascending amount：A=1.4；
When postprandial blood sugar change is overall in rising trend in injection three days of object, and blood glucose maximum and blood glucose minimum value phase When being more than 40% than ascending amount：A=1.5；And
When postprandial blood sugar change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose maximum phase Than slippage when within 10%：A=0.9；
When postprandial blood sugar change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose maximum phase It is more than 10% and when within 20% than slippage：A=0.8；
When postprandial blood sugar change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose maximum phase It is more than 20% and when within 30% than slippage：A=0.7；
When postprandial blood sugar change is overall on a declining curve in injection three days of object, and blood glucose minimum value and blood glucose maximum phase Than slippage when within 40%：A=0.6；And
Early drug injection amount L before the meal21=L2×0.6；
Drug injection amount L before dinner22=L2×0.4。
7. analyte monitoring and automatic chemical feeding system as described in claim 5 or 6, it is characterised in that wherein：
The outer surface of each working electrode is additionally provided with electro transfer layer.
8. analyte monitoring as claimed in claim 7 and automatic chemical feeding system, it is characterised in that wherein：
The working electrode in each detection part is formed from the reference electrode by different materials.
9. analyte monitoring as claimed in claim 8 and automatic chemical feeding system, it is characterised in that further comprise：
Personal information can be inputted analyte monitoring and automatic chemical feeding system by input block, user by input block, and And the computing unit is calculated according to the personal information inputted in the use；
Setup unit, user can be set by setup unit to analyte monitoring with automatic chemical feeding system；And
The input block, the setup unit are electrically connected with described control unit.
10. analyte monitoring as claimed in claim 9 and automatic chemical feeding system, it is characterised in that further comprise：
Comparing unit, it is corresponding with the testing result of each detection part that the comparing unit is obtained to the processing unit Processing numerical value is compared one by one respectively, and the monitoring fiducial value obtained more afterwards one by one and monitoring threshold set in advance are divided It is not compared；Also, the total injection volume for the medicine that the comparing unit calculates the computing unit and the medication Threshold value is compared；With
Tip element, if the monitoring fiducial value that the comparing unit is obtained is more than the monitoring threshold and/or the meter The total injection volume for calculating the medicine that unit is calculated is less than the medication threshold value, and the Tip element sends cue；And
The comparing unit and the Tip element are electrically connected with described control unit respectively.
11. analyte monitoring as claimed in claim 10 and automatic chemical feeding system, it is characterised in that further comprise：
Display unit, the display unit is used for the result of calculation for showing the computing unit；With
Storage element, the storage element is stored to the result of calculation of the computing unit；And
The display unit is electrically connected with described control unit respectively with the storage element.
12. analyte monitoring and automatic chemical feeding system described in claim 11, it is characterised in that further comprise：
Transmitter unit, the transmitter unit is stored up in the result of calculation and/or the storage element for sending the computing unit The result of calculation deposited.
13. analyte monitoring as claimed in claim 12 and automatic chemical feeding system, it is characterised in that wherein：
The processing unit, the computing unit, the display unit, the storage element, the comparing unit, the input Unit, the setup unit, the Tip element, the transmitter unit and described control unit are packaged in same housing.
CN201710308313.7A 2017-05-04 2017-05-04 A kind of analyte monitoring and automatic chemical feeding system Pending CN106983951A (en)

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