CN108209942B - A kind of non-invasive continuous blood sugar measuring system - Google Patents
A kind of non-invasive continuous blood sugar measuring system Download PDFInfo
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- CN108209942B CN108209942B CN201711381140.8A CN201711381140A CN108209942B CN 108209942 B CN108209942 B CN 108209942B CN 201711381140 A CN201711381140 A CN 201711381140A CN 108209942 B CN108209942 B CN 108209942B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1477—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means non-invasive
Abstract
The invention discloses a kind of non-invasive continuous blood sugar measuring systems.The present invention is by way of electro-ionic osmosis by importing positively charged regulation and control substance in positive electrode subcutaneously tissue fluid, the osmotic balance of artificial adjustment blood and tissue fluid, so that the glucose in blood actively flows in tissue fluid outside, the glucose in tissue fluid is driven to skin surface driving to skin surface in such a way that reverse ion permeates by negative electrode by the glucose of glucose original in tissue fluid and blood outflow again, realizes noninvasive continuous measurement；The present invention is completely noninvasive, and the adverse reaction of skin will not be caused in measurement, combines with wearable blood glucose measurement device and noninvasive continuous blood sugar monitoring may be implemented；The present invention increases the content for the glucose that can be measured to, and improve the degree of correlation of measurement object Yu blood blood glucose, improves the precision of measurement in such a way that control glucose in blood actively outflows, and is suitble to the blood sugar monitoring with medical grade.
Description
Technical field
The present invention relates to medical measurement fields, and in particular to a kind of non-invasive continuous blood sugar measuring system.
Background technique
Diabetes have become the serious disease for endangering human health, and according to the statistics of the World Health Organization, 2015 complete
Ball diabetic has more than 400,000,000 people, will be more than 600,000,000 people to the year two thousand forty.The number of diabetic patients in China occupies the whole world first, has super
Cross 100,000,000 people's illness.With the increasing living standards of the people with the reasons such as poverty of movement, more and more people's overweight,
Obesity, and then induced Diabetic.The age of onset of diabetes is gradually lowered, and more and more young people have suffered from sugar long since
Urine disease.According to statistics, there is 5 people potential glycosuria with higher in the whole world in every 10 people every about just there is 1 people to suffer from diabetes in 10 people
Sick risk.If the blood glucose level of diabetic cannot be well controlled, can cause eye, oral cavity, angiocarpy,
The complication of the multiple organs such as kidney, foot, serious person will lead to death, therefore control blood glucose level in stable range to sugar
Urine patient extends the service life and quality of supporting the family is most important.Diabetes can not be cured completely, by keeping on a diet, enhancing
Physical training and the lifelong mode with composite medicine and injection of insulin control blood glucose level.In order to control blood sugar concentration, need to lead to
The mode for crossing medical instrument measurement obtains real-time blood glucose level.The current most common blood sugar measuring method is by puncturing finger
A certain amount of fingerstick capillary blood is drawn, and is detected by blood glucose meter.General diabetic needs to measure 3 within one day~
4 times, serious patient needs to measure more times.This measurement method be belong to invasive measurement means, and every time measure when meeting
Cause the pain of patient, long-term measurement will lead to finger raw cocoon, finger wound bacterium infection, and because of its long-term pain and not
It is suitable, patient compliance can be made psychological, cause the compliance of blood glucose measurement poor.
In addition, the blood glucose level variation of people is a continuous change procedure, diet, movement and the change of physical condition are all
It can cause the fluctuation of blood glucose, the mode of finite number of time blood glucose measurement has certain limitation within mesh the previous day, can not be accurate
At the time of with completely knowing that blood glucose is more than normal value and is lower than normal value.In addition under as people, blood glucose is had significantly in sleep
Drop, hypoglycemia can cause fatal as a result, and blood sugar tester measuring method cannot achieve sleep at present for diabetic
In blood glucose measurement.For diabetic, in real time and continuous blood glucose measurement is most effective and safe blood glucose level
Monitoring means, and because continuous measurement needs to measure mass data, therefore it is required that this blood sugar measuring method be it is noninvasive or
Minimally invasive, to lower the pain of patient.
For the product that minimally invasive blood glucose continuously measures using brands such as Medtronic, Abbott Laboratories, moral health as representative, method is soft by one
Needle is inserted into the subcutaneous simultaneously long periods of wear of patient, and the concentration of glucose measured in patient's hypodermis liquid obtains Portugal in continuous tissue fluid
Grape sugar concentration value, because concentration of glucose and blood blood sugar concentration are positively correlated in tissue fluid, the measurement of tissue fluid can be with one
Determine the concentration variation that blood glucose is represented in degree, but this method still falls within invasive measurement method, and patient worn is inconvenient,
Long-time service can cause pain, and in addition the particularly relevant relationship of the concentration of glucose of tissue fluid and the concentration of glucose in blood is not true
It is fixed, and the hysteresis quality with certain time.
The product of Woundless blood sugar measurement is mostly with infrared spectroscopy, Raman spectrum, Skin Resistance, heat metabolism, electromagnetic measurement
Based on, the principle of measurement depends on response of the glucose to different environmental stimuli signals, measurement of the principles above to glucose
Poor specificity, be easy to be disturbed in the presence of the substances such as hydrone, red blood cell, measurement inaccuracy, therefore can be at
For by medical approval non-invasive continuous blood sugar measuring system.The Woundless blood sugar that unique one kind was once authenticated and sold by FDA is surveyed
Amount product glucowatch uses reverse ion permeating method, but this method needs to apply biggish electric current to skin
Skin surface detection is rushed to outside glucose for driving in tissue fluid, but for a long time using red swelling of the skin and allergy etc. can be caused
Reaction, is finally stopped production and selling.There is presently no one kind can really realize that continuous blood sugar that is noninvasive and accurately measuring is surveyed
Amount method.
Summary of the invention
For the above problems of the prior art, the invention proposes a kind of non-invasive continuous blood sugar measuring systems.
Non-invasive continuous blood sugar measuring system of the invention includes: regulation and control substance, positive electrode, negative electrode, power supply and skin
The glucose meters on surface；Wherein, positive electrode and negative electrode are individually positioned in skin surface, and are respectively connected to power supply；?
The regulation and control substance of setting volume and concentration is placed between positive electrode and skin；Regulation and control substance is the osmotic pressure that can change tissue fluid
Substance, the form of regulation and control substance is paste, gel, condensation shape or sticker shape；The modes of emplacement of regulation and control substance is to be applied to
Positive electrode surface is applied to the corresponding skin surface of positive electrode or is pasted onto positive electrode surface；Regulation and control substance has positive electricity；Electricity
Source forms direction perpendicular to the electric field of skin in skin surface by positive electrode, and direction is directed toward in skin, and electro-ionic osmosis is passed through
It is subcutaneous that mode drives the regulation and control substance with positive electricity to enter；After regulation and control substance enters tissue fluid, the osmotic pressure of tissue fluid is improved,
The increase of osmotic pressure causes blood to increase to the filtration pressure of tissue fluid, because filtration pressure is directly proportional to filtrable volume, in blood
Filtration enhancing of the glucose into tissue fluid, eventually lead to glucose filtration blood vessel in the blood actively outer tissue that flows to
The molal weight of liquid increases, and the quality of increased glucose and the incrementss of filtration pressure are directly proportional；Power supply is by negative electrode in skin
Skin surface forms direction perpendicular to the electric field of skin, and direction is directed toward outside skin, by tissue fluid in such a way that reverse ion permeates
In glucose drive to skin surface, form skin surface glucose；Skin is measured by the glucose meters of skin surface
The concentration I of skin surface glucose, and according to the Proportional coefficient K demarcated in advance, so that the glucose obtained in the blood of human body is dense
Spend C=KI.
Before measuring blood sugar concentration, need first to demarcate proportionality coefficient: the regulation and control substance of setting volume and concentration is placed on skin
Between skin surface and positive electrode, the direction electric field inside perpendicular to skin is applied by positive electrode, drives positively charged modulator
Matter enters tissue fluid, so that the glucose increased in blood penetrates into tissue fluid, applies direction perpendicular to skin by negative electrode
The outside electric field of skin drives the glucose in tissue fluid to skin surface, measures skin by the glucose meters of skin surface
The concentration I of skin surface glucose0, the glucose of blood at this time is obtained using measurement fingerstick capillary blood or venous blood blood measurement
Concentration C0, obtain under the regulation and control substance of setting volume and concentration, the concentration I of skin surface glucose0It is dense with the glucose of blood
Spend C0Between Proportional coefficient K: K=C0/I0。
The volumetric concentration of regulation and control substance is set as 0.05%~0.5%；The volume of regulation and control substance is set as 0.33~5000 μ
L；The volume and concentration of regulation and control substance with calibration proportionality coefficient when volume and concentration it is identical.
Glucose penetrates the infiltration of vascular wall in the source of glucose autoblood of tissue fluid, therefore glucose is dense in tissue fluid
The concentration of glucose of degree and blood has determining proportionate relationship, but medical diagnosis is not fully achieved in the degree of correlation of the two
Level can cause the error of measurement, more than the allowable error of clinical diagnosis so the proportionate relationship of its concentration is no longer applicable in sometimes
Range.The quality of the net outflow into tissue fluid of the glucose in blood is enhanced by regulation and control substance, the Portugal in such tissue fluid
The degree of correlation of the concentration of glucose of grape sugar concentration and blood will greatly improve, can be within the scope of clinical diagnosis tolerance
Using the proportionate relationship of interstitial fluid glucose concentration and blood glucose concentration, reach measurement interstitial fluid glucose concentration
Compare the effect for preparing to be back-calculated to obtain blood glucose concentration.The incipient stage of Woundless blood sugar measurement is carried out by this method, is needed
It to be demarcated and be corrected using measurement fingerstick capillary blood or the result that measures Woundless blood sugar of venous blood blood glucose, for making
User determines to meet the interstitial fluid glucose concentration of its people's concrete condition and the proportionate relationship of blood glucose concentration, as
The transformational relation of measurement result and blood glucose level.
Regulation and control substance is greater than 1,000,000 one of hyaluronic acid, glycoprotein, amino acid and fatty acid using molecular weight.
Driving time is between 10~30 minutes；The area of positive electrode and negative electrode is in 1~30cm2Between.Power supply is perseverance
Potential source or constant-current source；The output voltage of constant pressure source is between 2~5V；The output electric current of constant-current source is 0.5~10mA/cm2, positive electricity
Centre distance between pole and negative electrode is 1~5cm.
The shape of positive electrode and negative electrode is round, rectangular or irregular shape；Positive electrode and negative electrode use conductive material
Matter, metal, conducting polymer or conductive oxide semiconductor；Metal example is one of gold, silver, copper, aluminum and zinc；Conduction is poly-
Conjunction object is one of polythiophene, polypyrrole, polyethylene dioxythiophene and polyaniline, and conductive oxide semiconductor is indium oxide
Tin.
The glucose meters of skin surface are using glucose oxidase biosensor, infrared spectrometry instrument, drawing
Graceful spectroscopic glucose measuring instrument, micro-fluid chip, the glucose sensor based on field-effect tube, fluorescence reaction glucose sensing
One of device.
Advantages of the present invention:
The present invention is by way of electro-ionic osmosis by importing positively charged regulation and control substance, people in positive electrode subcutaneously tissue fluid
It for the osmotic balance for regulating and controlling blood and tissue fluid, is flowed in tissue fluid so that glucose in blood is actively outer, then by tissue
The glucose of original glucose and blood outflow will be in tissue fluid by negative electrode in such a way that reverse ion permeates in liquid
Glucose drives to skin surface driving to skin surface, realizes noninvasive continuous measurement；The present invention is completely noninvasive, will not in measurement
The adverse reaction for causing skin combines with wearable blood glucose measurement device and noninvasive continuous blood sugar monitoring may be implemented；This
Invention increases the content for the glucose that can be measured to, and mention in such a way that control glucose in blood actively outflows
The high degree of correlation of measurement object and blood blood glucose, improves the precision of measurement, is suitble to and the blood sugar monitoring of medical grade.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of one embodiment of non-invasive continuous blood sugar measuring system of the invention.
Specific embodiment
With reference to the accompanying drawing, by specific embodiment, the present invention is further explained.
As shown in Figure 1, the non-invasive continuous blood sugar measuring system of the present embodiment includes: regulation and control substance 4, positive electrode 2, negative electrode
3, the glucose meters of constant pressure source 1 and skin surface；Wherein, positive electrode 2 and negative electrode 3 are individually positioned in skin surface 5,
And it is respectively connected to constant pressure source 1；The regulation and control substance 4 of setting volume and concentration is smeared between positive electrode and skin；Regulation and control substance
With positive electricity；Constant pressure source 1 forms the electric field perpendicular to skin in skin surface by positive electrode, and direction is directed toward in skin, is passed through
It is subcutaneous that the mode of electro-ionic osmosis drives the regulation and control substance with positive electricity to enter.
After people takes in sugar, the glucose that food decomposes enters in blood under the digestion and absorption effect of stomach,
Whole body is flowed through under the action of systemic blood circulation everywhere, the artery segment from artery blood flow to capillary, and through blood capillary
The vein end of pipe flows to vein blood vessel.Portugal in capillary region there is the mass exchange of tissue fluid and blood, in blood
Grape sugar penetrates blood vessel in the arterial end of capillary and enters tissue fluid, participates in the metabolic activity of cell, remaining grape
Sugar is returned in capillary by the vein end reabsorption of capillary.The intercoursing of blood and tissue fluid be decided by two kinds of liquid it
Between osmotic pressure and liquid pressure it is poor.In normal state, filtration is slightly stronger than reabsorption, is maintained in tissue fluid with this
Possess certain density glucose.The difference of filtration and reabsorption is effective filtration pressure, determines formula are as follows:
NDF=(Pc+πi)-(Pi+πc)
Wherein NDF is effective filtration pressure size, PcFor capillary pressure, πiFor tissue fluid osmotic pressure, PiIt is quiet for tissue fluid
Hydraulic pressure, πcFor plasma osmolarity.NDF > 0 under normal circumstances.
In the present invention, in the way of electro-ionic osmosis, apply a vertical steady electric field to skin surface to be measured, and
A certain amount of regulation and control substance is smeared between positive electrode anode and application on human skin, hyaluronic acid is the main component of tissue liquid,
And it is positively charged, it can be entered under the driving of electric field in subcutaneous tissue fluid, according to the formula of tissue fluid osmotic pressure:
πi=iMRT
Wherein, πiFor the size of osmotic pressure, i is permeability, and M is the molar concentration of solute, and R is ideal gas constant, T
For kelvin degree.The osmotic pressure that tissue fluid after the concentration of solute hyaluronic acid, can be improved in tissue fluid is improved, is not being changed
Under the premise of becoming other parameters, such operation will cause the raising of effective filtration pressure, and filtration pressure is directly proportional to filtrable volume, therefore
Filtration of the glucose in blood into tissue fluid at this time is enhanced, and reabsorption is weakened, and is eventually led in blood
Glucose filtration blood vessel enter tissue fluid amount increase.Concentration of glucose at this time in tissue fluid is higher, with blood in blood
The degree of correlation of sugared concentration variation is also higher.
By the way of electro-ionic osmosis and reverse ion infiltration mode, to skin apply electro-ionic osmosis electric field after modulator
The volume flow that matter is injected in Skin tissue fluid meets:
Wherein, JvFor volume flow, unit is volume × time-1× area-1, LVEFor electroosmotic flow coefficient,For in skin
Electric-force gradient, the regulation and control substance volume of electro-ionic osmosis tissue fluid is volume flow × electro-ionic osmosis time × electro-ionic osmosis electrode
Area.
Enter in subcutaneous tissue using iontophoresis driving regulation and control substance, the volume and volume flow of regulation and control substance are full
Sufficient above formula, in typical case, the range of volume flow are 1~600 μ L h-1cm-2Or 1~200 μ L h-1cm-2, 200~400
μL h-1cm-2, 400~600 μ L h-1cm-2, 200~400 μ L h-1cm-2, 100~500 μ L h-1cm-2, 200~500 μ L h- 1cm-2.At driving time 20 minutes, positive electrode and negative electrode were square, area 2m2In the case of, the modulator of electro-ionic osmosis
The volume of matter is within the scope of 0.33-5000 μ L, and volume range can also be 0.33~100 μ L, 100~1000 μ L, 1000~
2500 μ L, 2500~5000 μ L, 100~3000 μ L, 500~2500 μ L etc..
The noninvasive continuous blood sugar measurement method of the present embodiment, comprising the following steps:
1) proportionality coefficient is demarcated before measurement:
Driving volumetric concentration is 0.3%, molecular weight 2,000,000, and volume is that the hyaluronic acid regulation and control substance of 1000 μ L enters group
Liquid is knitted, so that the glucose increased in blood penetrates into tissue fluid, then drives glucose in tissue fluid to skin surface,
Using the glucose measuring method of skin surface, the concentration I of skin surface glucose is measured0, utilize measurement fingerstick capillary
Blood or venous blood blood measurement obtain the concentration of glucose C of blood at this time0, it obtains under the regulation and control substance of setting volume and concentration,
The concentration I of skin surface glucose0With the concentration of glucose C of blood0Between Proportional coefficient K: C0=KI0。
2) regulation and control substance 4 is smeared in the skin surface of human body, regulation and control substance uses hyaluronic acid.
3) subcutaneous tissue fluid is entered using iontophoresis driving hyaluronic acid:
A) positive electrode 2 is connected with the anode of constant pressure source 1, negative electrode 3 is connected with the cathode of constant pressure source 1；
B) positive electrode 2 and negative electrode 3 are directly attached to the skin surface of human body, and in the centre distance of skin surface
For 2cm；
C) start the voltage output of constant pressure source 1, voltage 3V.
4) by the molar concentration of control regulation and control substance, change the osmotic pressure of tissue fluid, increase blood by increasing osmotic pressure
For liquid to the filtration pressure of tissue fluid, filtration pressure is directly proportional to filtrable volume, to enhance mistake of the glucose into tissue fluid in blood 7
Filter effect, the osmotic balance of blood and tissue fluid eventually lead to and flow to tissue outside the glucose filtration blood vessel active in blood
Liquid is kept for 20 minutes.
5) under the driving of electric field, in such a way that reverse ion permeates, the glucose in tissue fluid 6 is flowed to by skin 5
The surface of negative electrode 3 and skin contact forms skin surface glucose 8.
6) glucose sensor is used, the concentration I of skin surface glucose 8 is measured, by Proportional coefficient K, to obtain
Concentration of glucose C=KI in the blood of human body.
It is finally noted that the purpose for publicizing and implementing example is to help to further understand the present invention, but this field
Technical staff be understood that without departing from the spirit and scope of the invention and the appended claims, it is various replacement and repair
It is all possible for changing.Therefore, the present invention should not be limited to embodiment disclosure of that, and the scope of protection of present invention is to weigh
Subject to the range that sharp claim defines.
Claims (9)
1. a kind of non-invasive continuous blood sugar measuring system, which is characterized in that the blood sugar measuring system includes: regulation and control substance, positive electricity
Pole, negative electrode, power supply and skin surface glucose meters；Wherein, the positive electrode and negative electrode are individually positioned in skin
Skin surface, and it is respectively connected to power supply；The regulation and control substance of setting volume and concentration is placed between positive electrode and skin；The tune
Control substance is the substance that can change the osmotic pressure of tissue fluid, and the form of regulation and control substance is paste, gel, condensation shape or sticker
Shape；The modes of emplacement of regulation and control substance is to be applied to positive electrode surface, be applied to the corresponding skin surface of positive electrode or be pasted onto
Positive electrode surface；Regulation and control substance has positive electricity；The power supply forms direction perpendicular to skin in skin surface by positive electrode
Electric field, direction are directed toward in skin, drive the regulation and control substance with positive electricity to enter by way of electro-ionic osmosis subcutaneous；Regulation and control substance
Into after tissue fluid, the osmotic pressure of tissue fluid is improved, the increase of osmotic pressure causes blood to increase to the filtration pressure of tissue fluid, because
It is directly proportional to filtrable volume for filtration pressure, so filtration enhancing of the glucose in blood into tissue fluid, eventually leads to blood
Actively the outer molal weight for flowing to tissue fluid increases glucose filtration blood vessel in liquid, the quality and filtration pressure of increased glucose
Incrementss it is directly proportional；Power supply forms direction perpendicular to the electric field of skin in skin surface by negative electrode, and skin is directed toward in direction
Outside, the glucose in tissue fluid is driven to skin surface in such a way that reverse ion permeates, forms skin surface glucose；
The concentration I of skin surface glucose is measured by the glucose meters of skin surface, and according to the proportionality coefficient demarcated in advance
K, to obtain the concentration of glucose C=KI in the blood of human body.
2. blood sugar measuring system as described in claim 1, which is characterized in that before measuring blood sugar concentration, demarcate proportionality coefficient
K: setting volume and the regulation and control substance of concentration are placed between skin surface and positive electrode, by positive electrode apply direction perpendicular to
The inside electric field of skin, drives positively charged regulation and control substance to enter tissue fluid, so that the glucose increased in blood penetrates into group
It knits in liquid, the direction electric field outside perpendicular to skin is applied by negative electrode, the glucose in driving tissue fluid to skin surface,
The concentration I of skin surface glucose is measured by the glucose meters of skin surface0, using measurement fingerstick capillary blood or
Venous blood measurement obtains the concentration of glucose C of blood at this time0, obtain under the regulation and control substance of setting volume and concentration, skin table
The concentration I of face glucose0With the concentration of glucose C of blood0Between Proportional coefficient K: K=C0/I0。
3. blood sugar measuring system as described in claim 1, which is characterized in that the regulation and control substance of the setting volume and concentration
Volumetric concentration is 0.05%~0.5%；The volume of the regulation and control substance of volume and concentration is set as 0.33~5000 μ L.
4. blood sugar measuring system as described in claim 1, which is characterized in that the regulation and control substance is greater than 100 using molecular weight
One of ten thousand hyaluronic acid, glycoprotein, amino acid and fatty acid.
5. blood sugar measuring system as described in claim 1, which is characterized in that driving time is between 10~30 minutes；It is described
The area of positive electrode and negative electrode is in 1~30cm2Between.
6. blood sugar measuring system as described in claim 1, which is characterized in that the power supply is constant pressure source or constant-current source；Constant pressure
The output voltage in source is between 2~5V；The output electric current of constant-current source is 0.5~10mA/cm2, between positive electrode and negative electrode
Centre distance is 1~5cm.
7. blood sugar measuring system as described in claim 1, which is characterized in that the shape of the positive electrode and negative electrode is circle
Shape, rectangular or irregular shape.
8. blood sugar measuring system as described in claim 1, which is characterized in that the positive electrode and negative electrode use metal, lead
The conductive materials of electric polymer or conductive oxide semiconductor.
9. blood sugar measuring system as described in claim 1, which is characterized in that the glucose meters of the skin surface use
Glucose oxidase biosensor, infrared spectrometry instrument, Raman spectrum glucose measuring instrument, micro-fluid chip, base
In one of the glucose sensor of field-effect tube and fluorescence reaction glucose sensor.
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| CN201711381140.8A CN108209942B (en) | 2017-12-20 | 2017-12-20 | A kind of non-invasive continuous blood sugar measuring system |
| PCT/CN2018/102441 WO2019119851A1 (en) | 2017-12-20 | 2018-08-27 | Non-invasive continuous blood glucose measurement system |
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| CN201711381140.8A CN108209942B (en) | 2017-12-20 | 2017-12-20 | A kind of non-invasive continuous blood sugar measuring system |
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| CN108209942B (en) * | 2017-12-20 | 2019-05-24 | 清华大学 | A kind of non-invasive continuous blood sugar measuring system |
| CN112438704B (en) * | 2019-08-31 | 2024-02-23 | 深圳硅基传感科技有限公司 | Calibration system of physiological parameter monitor |
| CN114557694B (en) * | 2022-04-28 | 2022-09-23 | 中国科学院大学 | Noninvasive subcutaneous tissue fluid extraction-detection device and extraction-detection method |
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|---|---|---|---|---|
| CN101485573A (en) * | 2009-02-12 | 2009-07-22 | 薛萍 | Non-invasive blood sugar detection and monitoring instrument |
| CN101998840A (en) * | 2008-03-31 | 2011-03-30 | 奥纳波莱波公司 | Method and device for non-invasive determination of the concentration of a substance in a body fluid |
| CN102119860A (en) * | 2010-01-12 | 2011-07-13 | 长庚医疗器材股份有限公司 | Electrode patch and noninvasive glucose measurement system and method |
| CN107296614A (en) * | 2017-05-22 | 2017-10-27 | 中山大学 | Blood sugar monitor based on biocompatibility electrode |
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| CN201767968U (en) * | 2010-08-12 | 2011-03-23 | 长庚医学科技股份有限公司 | Noninvasive blood glucose meter electrode structure |
| US9949675B2 (en) * | 2012-10-19 | 2018-04-24 | Convergence Biometrics, LLC | Noninvasive blood measurement platform |
| CN108209942B (en) * | 2017-12-20 | 2019-05-24 | 清华大学 | A kind of non-invasive continuous blood sugar measuring system |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101998840A (en) * | 2008-03-31 | 2011-03-30 | 奥纳波莱波公司 | Method and device for non-invasive determination of the concentration of a substance in a body fluid |
| CN101485573A (en) * | 2009-02-12 | 2009-07-22 | 薛萍 | Non-invasive blood sugar detection and monitoring instrument |
| CN102119860A (en) * | 2010-01-12 | 2011-07-13 | 长庚医疗器材股份有限公司 | Electrode patch and noninvasive glucose measurement system and method |
| CN107296614A (en) * | 2017-05-22 | 2017-10-27 | 中山大学 | Blood sugar monitor based on biocompatibility electrode |
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