CN106975536A - A kind of Purification of Taxol ultrasonic wave raw material reducing mechanism - Google Patents
A kind of Purification of Taxol ultrasonic wave raw material reducing mechanism Download PDFInfo
- Publication number
- CN106975536A CN106975536A CN201710231565.4A CN201710231565A CN106975536A CN 106975536 A CN106975536 A CN 106975536A CN 201710231565 A CN201710231565 A CN 201710231565A CN 106975536 A CN106975536 A CN 106975536A
- Authority
- CN
- China
- Prior art keywords
- pressure roller
- eccentric
- taxol
- ultrasonic wave
- purification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229930012538 Paclitaxel Natural products 0.000 title claims abstract description 29
- 229960001592 paclitaxel Drugs 0.000 title claims abstract description 29
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title claims abstract description 28
- 238000000746 purification Methods 0.000 title claims abstract description 18
- 239000002994 raw material Substances 0.000 title claims abstract description 15
- 238000007667 floating Methods 0.000 claims abstract description 31
- 241001149649 Taxus wallichiana var. chinensis Species 0.000 claims abstract description 23
- 230000006835 compression Effects 0.000 claims abstract description 22
- 238000007906 compression Methods 0.000 claims abstract description 22
- 238000005096 rolling process Methods 0.000 claims abstract description 9
- 238000013016 damping Methods 0.000 claims description 7
- 241001116500 Taxus Species 0.000 abstract description 10
- 239000003960 organic solvent Substances 0.000 abstract description 4
- 238000010276 construction Methods 0.000 abstract description 2
- 241000196324 Embryophyta Species 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- DSRNKUZOWRFQFO-UHFFFAOYSA-N cephalotaxine Natural products COC1=CC23CCCN2CCc4cc5OCOc5cc4C3=C1O DSRNKUZOWRFQFO-UHFFFAOYSA-N 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000002035 prolonged effect Effects 0.000 description 3
- 244000050510 Cunninghamia lanceolata Species 0.000 description 2
- 244000046052 Phaseolus vulgaris Species 0.000 description 2
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 2
- WZFZRXGNVSHCOI-UHFFFAOYSA-N acetylcephalotaxine Chemical compound C1=C2C3C(OC(C)=O)C(OC)=CC43CCCN4CCC2=CC2=C1OCO2 WZFZRXGNVSHCOI-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 244000144730 Amygdalus persica Species 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 241000222712 Kinetoplastida Species 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 235000008575 Pinus pinea Nutrition 0.000 description 1
- 240000007789 Pinus pinea Species 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 240000000147 Torreya grandis Species 0.000 description 1
- 235000016410 Torreya grandis Nutrition 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- YMNCVRSYJBNGLD-KURKYZTESA-N cephalotaxine Chemical compound C([C@@]12C=C([C@H]([C@H]2C2=C3)O)OC)CCN1CCC2=CC1=C3OCO1 YMNCVRSYJBNGLD-KURKYZTESA-N 0.000 description 1
- 239000000039 congener Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- -1 demethyl cephalotaxine Chemical compound 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 125000002456 taxol group Chemical group 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C4/00—Crushing or disintegrating by roller mills
- B02C4/02—Crushing or disintegrating by roller mills with two or more rollers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C19/00—Other disintegrating devices or methods
- B02C19/18—Use of auxiliary physical effects, e.g. ultrasonics, irradiation, for disintegrating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C21/00—Disintegrating plant with or without drying of the material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C4/00—Crushing or disintegrating by roller mills
- B02C4/28—Details
- B02C4/30—Shape or construction of rollers
Landscapes
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Extraction Or Liquid Replacement (AREA)
Abstract
The present invention provides a kind of Purification of Taxol ultrasonic wave raw material reducing mechanism, it is connected including eccentric wheel with rotating shaft key, if the eccentric wheel warp bolt stem and alignment pin are connected with an eccentric frame, described eccentric frame one end key connects an eccentric shaft, an active compression roller is connected with the eccentric shaft, the eccentric shaft right-hand end is provided with side floating shelf, the side floating shelf that can be moved left and right is arranged on body, the side floating shelf is respectively equipped with some deep-slotted chip breakers with side pressure roller respective horizontal, a spherical rolling element is provided with inside the deep-slotted chip breaker, the present invention is simple in construction, Chinese yew limb is crushed using the pressurization between the active compression roller and other two rods of eccentric structure, side pressure roller impacts the Chinese yew of side pressure roller both sides while Chinese yew is extruded with hyperfrequency, broken active principle in yew plant cells is set fully to be dissolved into organic solvent, without fermenting for a long time, taxol utilization rate in Chinese yew is high, it is safe and convenient to use.
Description
Technical field
Crushed and filled with ultrasonic wave raw material the invention belongs to Purification of Taxol technical field, more particularly to a kind of Purification of Taxol
Put.
Background technology
Chinese yew also known as cepehalotaxus fortunei, peach pine, mountain Chinese torreya, be distributed widely in all over the world, plant complete stool rich in cephalotaxine,
Epicephalotaxine, demethyl cephalotaxine, acetylcephalotaxine, cepehalotaxus fortunei ketone alkali, Scphalotaxine and taxol, with red
Contain Multiple components in the yew cream of the short leaf yew extract of beans China fir extremely congener：Yew alkali, taxol, yew element, purple
Shirt is peaceful, snakeskin sterone, parasol pine two-man act ketone, some noxious materials, glucosides pigment etc..Wherein the anti-Ca of taxol, anti-TB are active most
It is good, it is main anti-Ca in yew medicinal extract, anti-TB compositions and mainly uses composition.
Taxol is derived from a kind of natural cancer therapy drug of Chinese yew, with unique anticancer mechanism and definitely
Clinical efficacy, has been used to the clinical treatment of the cancers such as breast cancer, oophoroma, lung cancer, although expensive, but demand is not
It is disconnected to rise.In early days, taxol is extracted from natural bark of Ramulus et folium taxi cuspidatae and obtained, and the content in bark be only 0.01~
0.02%, produce a small amount of taxol, it is necessary to substantial amounts of bark of Ramulus et folium taxi cuspidatae.Due to production taxol, natural Chinese yew woods meets with
Serious destruction is arrived.Prolonged fermentation is needed during Chinese yew purification of paclitaxel, is made inside yew plant cells
The composition of taxol be dissolved into organic solvent, but the fermentation time of Chinese yew is long, inside yew plant cells
Active ingredient dissolution rate is low.
Therefore, it is very necessary with ultrasonic wave raw material reducing mechanism set forth herein a kind of Purification of Taxol.
The content of the invention
Active ingredient dissolution rate present in purification of paclitaxel process is crushed for existing Chinese yew lowly, is taken
Long technical problem, the present invention provides a kind of Purification of Taxol ultrasonic wave raw material reducing mechanism.
A kind of Purification of Taxol ultrasonic wave raw material reducing mechanism, including it is eccentric wheel, eccentric frame, active compression roller, flexible
Bar, damping spring, upper floating shelf, upper pressure roller, side pressure roller, hydraulic cylinder, side floating shelf, rotating shaft, eccentric shaft, transducer, body, rolling
Kinetoplast, deep-slotted chip breaker and feed end；Eccentric wheel is connected with rotating shaft key, if to be connected with one inclined for eccentric wheel warp bolt stem and alignment pin
Heart frame, described eccentric frame one end key connects and an active compression roller is connected with an eccentric shaft, the eccentric shaft, and the eccentric shaft is right
Side is provided with side floating shelf, and the side floating shelf that can be moved left and right is arranged on body, the side floating shelf and side pressure roller
Respective horizontal is respectively equipped with inside some deep-slotted chip breakers, the deep-slotted chip breaker and is provided with a spherical rolling element, the eccentric shaft
End is provided with directly over pressure roller on one, the upper pressure roller and is provided with a vertical expansion link, if being connected with inside the side floating shelf
Dry transducer, described side floating shelf one end is fixed on the piston rod of hydraulic cylinder, and the hydraulic cylinder is fixed on the body, institute
State between active compression roller, upper pressure roller provided with one can accommodate Chinese yew limb entrance feed end.
Preferably, the transducer electrical connection supersonic generator.
Preferably, the supersonic generator frequency is 0-40KHz.
Preferably, the upper pressure roller, side pressure roller, active compression roller three are mutually circumscribed.
Preferably, the active compression roller, upper pressure roller, some cross one another crush is evenly equipped with side pressure roller excircle
Pawl.
Preferably, the damping spring upper and lower ends for being sleeved on the expansion link press up against the upper floating shelf, body
On.
Compared with prior art, the present invention has the advantages that：The present invention is simple in construction, utilizes the master of eccentric structure
Chinese yew limb is crushed in dynamic pressurization between compression roller and other two rods, and side pressure roller is while Chinese yew is extruded
The Chinese yew of side pressure roller both sides is impacted with hyperfrequency, broken active principle in yew plant cells is fully dissolved
Into organic solvent, fermented without prolonged, the taxol utilization rate in Chinese yew is high, safe and convenient to use.
Brief description of the drawings
Fig. 1 is the overall structure figure of the present invention.
Fig. 2 is the structure chart of side pressure roller in Fig. 1 of the present invention.
Fig. 3 is rolling element partial enlarged drawing in Fig. 2 of the present invention.
In figure：
1- eccentric wheels, 2- eccentric frames, 3- actives compression roller, 4- expansion links, 5- damping springs, the upper floating shelf of 6-, press on 7-
Roller, 8- side pressures roller, 9- hydraulic cylinders, 10- sides floating shelf, 11- rotating shafts, 12- eccentric shafts, 13- transducers, 14- bodies, 15- are rolled
Body, 16- deep-slotted chip breakers, 17- feed ends.
Embodiment
The present invention is described further below in conjunction with accompanying drawing：
Embodiment：
As shown in accompanying drawing 1 to 3
The present invention provides a kind of Purification of Taxol ultrasonic wave raw material reducing mechanism, including eccentric wheel 1, eccentric frame 2, active
Compression roller 3, expansion link 4, damping spring 5, upper floating shelf 6, upper pressure roller 7, side pressure roller 8, hydraulic cylinder 9, side floating shelf 10, rotating shaft
11st, eccentric shaft 12, transducer 13, body 14, rolling element 15, deep-slotted chip breaker 16 and feed end 17；Eccentric wheel 1 connects with the key of rotating shaft 11
Connect, if eccentric wheel 1 passes through bolt stem and alignment pin is connected with an eccentric frame 2, one end key of eccentric frame 2 connects an eccentric shaft 12, eccentric
An active compression roller 3 is connected with axle 12, the right-hand end of eccentric shaft 12 is provided with side floating shelf 10, the side floating shelf that can be moved left and right
10 are arranged on body 14, and side floating shelf 10 is respectively equipped with some deep-slotted chip breakers 16, deep-slotted chip breaker 16 with the respective horizontal of side pressure roller 8
Inside is provided with a spherical rolling element 15, and the upper end of eccentric shaft 12 is provided with pressure roller 7 on one, and it is vertical that the upper surface of pressure roller 7 is provided with one
Expansion link 4, be connected with some transducers 13 inside side floating shelf 10, the one end of side floating shelf 10 is fixed in the piston of hydraulic cylinder 9
On bar, hydraulic cylinder 9 is fixed on body 14, and Chinese yew limb can be accommodated provided with one between active compression roller 3, upper pressure roller 7
The feed end 17 of entrance, transducer 13 electrical connection supersonic generator, supersonic generator frequency be 0-40KHz, upper pressure roller 7,
Side pressure roller 8, the three of active compression roller 3 are mutually circumscribed, active compression roller 3, upper pressure roller 7, be evenly equipped with the excircle of side pressure roller 8 it is some
Cross one another crushing pawl, the upper and lower ends of damping spring 5 for being sleeved on expansion link 4 press up against floating shelf 6, body 14
On.
Operation principle
It is general in order that Chinese yew limb, which is ground into before wood chip or particle, use, needs adjustment liquid during present invention work
The position of cylinder pressure 9, make pressure roller 7, side pressure roller 8 respectively with active compression roller 3 it is circumscribed or also can successively it is progressive elongation hydraulic cylinder 9 live
The length of stopper rod is crushed, and the feed end 17 between active compression roller 3, upper pressure roller 7 delivers the limb of Chinese yew, is turned
The axle band high-speed rotation of movable eccentric wheel 1, makes eccentric wheel 1 and eccentric frame 2 drive active compression roller 3 to rotate, when active compression roller 3 is close
During upper pressure roller 7 between the two feed end 17 deliver diseases on plant stalk extrude, then by side pressure roller 8 respectively with other
Two roller formation extruding forces, again pass by extruding of the side pressure roller 8 respectively with other two rollers, can make Chinese yew limb
Crush and some transducers 13 are connected with inside at the same time side floating shelf 10, transducer 13 is electrically connected frequency range for 0-
40KHz supersonic generator frequencies, the ultrasonic activation that transducer 13 is produced can occur the side pressure roller 8 in the outside of side floating shelf 10
Ultrasonic activation, plants the Chinese yew that side pressure roller 8 impacts the both sides of side pressure roller 8 while Chinese yew is extruded with hyperfrequency
Thing, enables broken active principle in yew plant cells to be fully dissolved into organic solvent, red without prolonged fermentation
Taxol utilization rate in beans China fir is high, safe and convenient to use, and side floating shelf 10 is respectively equipped with the respective horizontal of side pressure roller 8
A spherical rolling element 15 is provided with inside some deep-slotted chip breakers 16 and deep-slotted chip breaker 16, can be abundant while ultrasonic activation is effectively transmitted
Ensure crushing effect of the side pressure roller 8 to Chinese yew.
Using technical solutions according to the invention, or those skilled in the art is under the inspiration of technical solution of the present invention,
Similar technical scheme is designed, and reaches above-mentioned technique effect, is to fall into protection scope of the present invention.
Claims (6)
1. a kind of Purification of Taxol ultrasonic wave raw material reducing mechanism, it is characterised in that Purification of Taxol ultrasonic wave raw material
Reducing mechanism includes eccentric wheel (1), eccentric frame (2), active compression roller (3), expansion link (4), damping spring (5), upper floating shelf
(6), upper pressure roller (7), side pressure roller (8), hydraulic cylinder (9), side floating shelf (10), rotating shaft (11), eccentric shaft (12), transducer
(13), body (14), rolling element (15), deep-slotted chip breaker (16) and feed end (17)；Eccentric wheel (1) is connected with rotating shaft (11) key, institute
Eccentric wheel (1) is stated if warp bolt stem and alignment pin are connected with an eccentric frame (2), described eccentric frame (2) one end key connection one is eccentric
An active compression roller (3) is connected with axle (12), the eccentric shaft (12), eccentric shaft (12) right-hand end floats provided with side
Frame (10), the side floating shelf (10) that can be moved left and right is arranged on body (14), the side floating shelf (10) and side pressure roller
(8) respective horizontal is respectively equipped with inside some deep-slotted chip breakers (16), the deep-slotted chip breaker (16) and is provided with a spherical rolling element
(15), eccentric shaft (12) upper end is provided with pressure roller (7) on one, one is provided with directly over the upper pressure roller (7) vertical flexible
Some transducers (13) are connected with inside bar (4), the side floating shelf (10), described side floating shelf (10) one end is fixed in hydraulic pressure
On the piston rod of cylinder (9), the hydraulic cylinder (9) is fixed on the body (14), the active compression roller (3), upper pressure roller (7)
Between provided with one can accommodate Chinese yew limb entrance feed end (17).
2. Purification of Taxol as claimed in claim 1 ultrasonic wave raw material reducing mechanism, it is characterised in that the transducer
(13) supersonic generator is electrically connected.
3. Purification of Taxol as claimed in claim 2 ultrasonic wave raw material reducing mechanism, it is characterised in that the ultrasonic wave hair
Raw device frequency is 0-40KHz.
4. Purification of Taxol as claimed in claim 1 ultrasonic wave raw material reducing mechanism, it is characterised in that the upper pressure roller
(7), side pressure roller (8), active compression roller (3) three are mutually circumscribed respectively.
5. Purification of Taxol as claimed in claim 1 ultrasonic wave raw material reducing mechanism, it is characterised in that the active extruding
Roller (3), upper pressure roller (7), it is evenly equipped with some cross one another crushing pawls on side pressure roller (8) excircle.
6. Purification of Taxol as claimed in claim 1 ultrasonic wave raw material reducing mechanism, it is characterised in that be sleeved on described stretch
Damping spring (5) upper and lower ends of contracting bar (4) press up against the upper floating shelf (6), on body (14).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710231565.4A CN106975536B (en) | 2017-04-11 | 2017-04-11 | A kind of Purification of Taxol ultrasonic wave raw material grinding device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710231565.4A CN106975536B (en) | 2017-04-11 | 2017-04-11 | A kind of Purification of Taxol ultrasonic wave raw material grinding device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106975536A true CN106975536A (en) | 2017-07-25 |
| CN106975536B CN106975536B (en) | 2018-10-19 |
Family
ID=59344524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710231565.4A Expired - Fee Related CN106975536B (en) | 2017-04-11 | 2017-04-11 | A kind of Purification of Taxol ultrasonic wave raw material grinding device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106975536B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108553935A (en) * | 2018-03-22 | 2018-09-21 | 孙学中 | A kind of multi-stage crushing device for the extraction of effective ingredients in plant medicine |
| CN110227598A (en) * | 2019-05-23 | 2019-09-13 | 北京科技大学 | A kind of accurate crushing device of hot mine of rare earth |
| CN112058387A (en) * | 2020-08-31 | 2020-12-11 | 张茂排 | Building is useless to synthesize again and is recycled shredding system admittedly |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108553935A (en) * | 2018-03-22 | 2018-09-21 | 孙学中 | A kind of multi-stage crushing device for the extraction of effective ingredients in plant medicine |
| CN110227598A (en) * | 2019-05-23 | 2019-09-13 | 北京科技大学 | A kind of accurate crushing device of hot mine of rare earth |
| CN110227598B (en) * | 2019-05-23 | 2020-07-31 | 北京科技大学 | Accurate breaker of tombarthite hot mine |
| CN112058387A (en) * | 2020-08-31 | 2020-12-11 | 张茂排 | Building is useless to synthesize again and is recycled shredding system admittedly |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106975536B (en) | 2018-10-19 |
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