CN103520236A - Preparation method of panax quinquefolius ultrafine blunt powder oral decoction tablets - Google Patents
Preparation method of panax quinquefolius ultrafine blunt powder oral decoction tablets Download PDFInfo
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- CN103520236A CN103520236A CN201310387183.2A CN201310387183A CN103520236A CN 103520236 A CN103520236 A CN 103520236A CN 201310387183 A CN201310387183 A CN 201310387183A CN 103520236 A CN103520236 A CN 103520236A
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- panacis quinquefolii
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Abstract
The invention discloses a preparation method of panax quinquefolius ultrafine blunt powder oral decoction tablets. The preparation method comprises the following steps: 1, dedusting and cleaning a panax quinquefolius raw material; 2, drying the panax quinquefolius raw material; 3, putting the panax quinquefolius raw material well treated in the step 2 into liquid nitrogen, and crushing at minus 196 DEG C; 4, putting drying the crushed panax quinquefolius raw material in a low pressure place for drying, and controlling the water content to be less than 20%; 5, performing cobalt-60 irradiation on the ultrafine powder formed in the step 4, and tabletting to obtain the oral decoction tablets. By adopting the preparation method with novel steps, the oral decoction tablets which are convenient to use are finally prepared, the biological availability of the product is improved, the biological availability of active ingredients of the panax quinquefolius can be effectively improved, the pure powder tablets can ensure the product quality, the appearance properties and hardness of the product meet quality standard requirements of tablets, and the dissolution rate is increased.
Description
Technical field
The invention belongs to pharmaceutical grade field of health care products, relate in particular to the preparation method of the oral decoction pieces of the blunt powder of a kind of Radix Panacis Quinquefolii ultra micro.
Background technology
Radix Panacis Quinquefolii (Panax quinquefolius) is a kind of of Radix Ginseng, is Araliaceae Radix Panacis Quinquefolii
panax quinquefoliuml. dry root.Be to originate in the Canadian a kind of high-end tonic herb of the U.S., have the effect of resisting fatigue, antioxidation, anti-stress, anticoagulant, reduction blood coagulation, diabetics is regulated in addition to the effect of blood glucose.Its market using value is high.
At present, Radix Panacis Quinquefolii has been developed a large amount of health product, as by Radix Panacis Quinquefolii buccal tablets, is all need to mix with other medical materials use or add a large amount of adjuvants.Radix Panacis Quinquefolii is often thinly sliced use, but the method used and to exist Radix Panacis Quinquefolii ingredient to be difficult for leaching, and bioavailability is low, with after have residue.
Summary of the invention
The object of the present invention is to provide a kind of bioavailability that does not add any adjuvant, improving product, product is used the preparation method of the longer oral decoction pieces of the blunt powder of Radix Panacis Quinquefolii ultra micro of more convenient shelf-life.
For solving the problems of the technologies described above, the invention provides the preparation method of the oral decoction pieces of the blunt powder of a kind of Radix Panacis Quinquefolii ultra micro, comprise the following steps:
Step 1, the dedusting of Radix Panacis Quinquefolii raw material is cleaned;
Step 2, Radix Panacis Quinquefolii raw material is dried;
Step 3, the Radix Panacis Quinquefolii raw material that step 2 is handled well are put into liquid nitrogen, at-196 ℃, pulverize;
Step 4, the Radix Panacis Quinquefolii raw material after pulverizing is put in low pressure dry, moisture Control is less than to 20%;
Step 5, the ultra-micro powder that step 4 is formed carry out Co 60 irradiation, and tabletting makes.
The present invention improves to be had, and adopts monotubular eccentric sphere grinding machine to pulverize in described step 2.
The present invention improves to be had, and the low pressure in described step 3 is 20-30KN.
The invention has the beneficial effects as follows: by the manufacture method of novel steps, finally made oral decoction pieces easy to use, improved the bioavailability of product, can effectively improve the bioavailability of Radix Panacis Quinquefolii active component, pure powder sheet can guarantee product quality, product appearance character and hardness meet tablet quality standard-required, and dissolution increases.
The specific embodiment
By describing technology contents of the present invention, structural feature in detail, being realized object and effect, below in conjunction with embodiment, be explained in detail.
The preparation method that the invention provides the oral decoction pieces of the blunt powder of a kind of Radix Panacis Quinquefolii ultra micro, comprises the following steps:
Step 1, the dedusting of Radix Panacis Quinquefolii raw material is cleaned, can directly adopt clear water effectively to clean raw material.
Step 2, Radix Panacis Quinquefolii raw material is dried, dryly can directly adopts drying equipment in the present embodiment, such as adopting drying machine or dehydrator etc.
Step 3, the Radix Panacis Quinquefolii raw material that step 2 is handled well are put into liquid nitrogen, at-196 ℃, pulverize;
Concrete; during pulverizing, can adopt monotubular eccentric sphere grinder; adopt liquid nitrogen as medium; ambient temperature is controlled at-196 ℃ and pulverizes; the powder of pulverizing out gained is thin; good fluidity, be convenient to the direct compression in later stage, and pulverize at low temperature process is conducive to protect the heat-sensitive ingredients in Cordyceps.
Step 4, the Radix Panacis Quinquefolii raw material after pulverizing is put in low pressure dry, moisture Control is less than to 20%, concrete, above-mentioned low voltage control, between 20-30KN, when the water content of Radix Panacis Quinquefolii being controlled to 20% when following, can directly realize the object of powder tabletting.
Step 4, the ultra-micro powder that step 4 is formed carry out Co 60 irradiation, and tabletting makes.
Radix Panacis Quinquefolii is ground into ultra-micro powder direct compression by high-tech technology and makes oral decoction pieces easy to use, improved the bioavailability of product, product is used more convenient, and the shelf-life is longer.
The foregoing is only embodiments of the invention; not thereby limit the scope of the claims of the present invention; every equivalent structure or conversion of equivalent flow process that utilizes description of the present invention to do; or be directly or indirectly used in other relevant technical fields, be all in like manner included in scope of patent protection of the present invention.
Claims (3)
1. a preparation method for the oral decoction pieces of the blunt powder of Radix Panacis Quinquefolii ultra micro, is characterized in that, comprises the following steps:
Step 1, the dedusting of Radix Panacis Quinquefolii raw material is cleaned;
Step 2, Radix Panacis Quinquefolii raw material is dried;
Step 3, the Radix Panacis Quinquefolii raw material that step 2 is handled well are put into liquid nitrogen, at-196 ℃, pulverize;
Step 4, the Radix Panacis Quinquefolii raw material after pulverizing is put in low pressure dry, moisture Control is less than to 20%;
Step 5, the ultra-micro powder that step 4 is formed carry out Co 60 irradiation, and tabletting makes.
2. the preparation method of the oral decoction pieces of the blunt powder of Radix Panacis Quinquefolii ultra micro according to claim 2, is characterized in that, adopts monotubular eccentric sphere grinding machine to pulverize in described step 2.
3. the preparation method of the oral decoction pieces of the blunt powder of Radix Panacis Quinquefolii ultra micro according to claim 2, is characterized in that, the low pressure in described step 3 is 20-30KN.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310387183.2A CN103520236A (en) | 2013-08-30 | 2013-08-30 | Preparation method of panax quinquefolius ultrafine blunt powder oral decoction tablets |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310387183.2A CN103520236A (en) | 2013-08-30 | 2013-08-30 | Preparation method of panax quinquefolius ultrafine blunt powder oral decoction tablets |
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| CN103520236A true CN103520236A (en) | 2014-01-22 |
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| CN201310387183.2A Pending CN103520236A (en) | 2013-08-30 | 2013-08-30 | Preparation method of panax quinquefolius ultrafine blunt powder oral decoction tablets |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105902587A (en) * | 2016-04-29 | 2016-08-31 | 河北林益堂药业有限公司 | Preparation method of panax quinquefolius raw powder tablets |
| CN107402276A (en) * | 2016-05-21 | 2017-11-28 | 广州今典精方药业有限公司 | The quality standard and manufacturing process of the American Ginseng qualitative, quantitative prepared slices of Chinese crude drugs |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101332212A (en) * | 2007-09-30 | 2008-12-31 | 张雪峰 | Aweto micropowder tablet and preparation method thereof |
| CN102406679A (en) * | 2011-11-30 | 2012-04-11 | 中山市中智药业集团有限公司 | Traditional Chinese medicine American ginseng buccal tablet |
-
2013
- 2013-08-30 CN CN201310387183.2A patent/CN103520236A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101332212A (en) * | 2007-09-30 | 2008-12-31 | 张雪峰 | Aweto micropowder tablet and preparation method thereof |
| CN102406679A (en) * | 2011-11-30 | 2012-04-11 | 中山市中智药业集团有限公司 | Traditional Chinese medicine American ginseng buccal tablet |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105902587A (en) * | 2016-04-29 | 2016-08-31 | 河北林益堂药业有限公司 | Preparation method of panax quinquefolius raw powder tablets |
| CN107402276A (en) * | 2016-05-21 | 2017-11-28 | 广州今典精方药业有限公司 | The quality standard and manufacturing process of the American Ginseng qualitative, quantitative prepared slices of Chinese crude drugs |
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Application publication date: 20140122 |