CN106975050B - 用于治疗虚劳癥积所致白血病的中药复方制剂及制备方法 - Google Patents
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Abstract
一种用于治疗虚劳癥积所致白血病的中药复方制剂及制备方法。制剂由用量为重量比的下列药物原料制成:生黄芪18—48、青蒿6—15、秦艽6—15、炙鳖甲18—48、生牡蛎18—48、三棱9—24、莪术9—24、半枝莲9—24、白花蛇舌草9—24、山慈菇6—15、铁树叶6—15、夏枯草18—48、猫爪草9—24、银柴胡4—10。本发明制剂是采用水煮提取的方法来提取原料药物中的有效成分,并保持其活性,这样不仅可使药物中有效成分的溶出度大大提高,而且有助于药物的吸收,从而能够提高其生物利用度。另外,药物为纯中药复方制剂,因而患者长期服用后不会产生毒副作用,所以安全性好。此外,制备方法工艺简单,操作方便。
Description
技术领域
本发明涉及一种中药制剂及其制备方法,特别是涉及一种以中药为原料制成的用于治疗虚劳癥积所致白血病的中药复方制剂及制备方法。
背景技术
白血病又称血癌,是由于正气内虚、温热毒邪乘虚而入引起的,以热毒、血瘀、痰浊互结,人体伤血为基本病机,以发热、出血、贫血及肝、脾、***肿大等为主要临床表现的一种造血***的恶性肿瘤。虽然目前临床上用于治疗白血病的药物品种很多,但针对性不强,而且部分药物的毒副作用大,所以服用后对于治疗属于虚劳癥积所致的白血病这种疾病来说效果不明显。
发明内容
为了解决上述问题,本发明的目的在于提供一种用于治疗虚劳癥积所致白血病的中药复方制剂及制备方法。
为了达到上述目的,本发明提供的用于治疗虚劳癥积所致白血病的中药复方制剂由用量为重量比的下列药物原料制成:
生黄芪18—48 青蒿6—15 秦艽6—15 炙鳖甲18—48 生牡蛎18—48 三棱9—24莪术9—24 半枝莲9—24 白花蛇舌草9—24 山慈菇6—15 铁树叶6—15 夏枯草18—48 猫爪草9—24 银柴胡4—10
所述的用于治疗虚劳癥积所致白血病的中药复方制剂的制备方法是按照下列步骤顺序进行∶
(a)将炙鳖甲和生牡蛎按照配比进行称量并混合,然后加水煎煮一次30分钟而制成炙鳖甲和生牡蛎煎煮液;
(b)将上述药物原料中除炙鳖甲和生牡蛎之外的其它药物原料按照配比进行称量并混合,然后加水浸泡25分钟,再将步骤(a)中的炙鳖甲和生牡蛎及其煎煮液加入混合,煎煮30分钟,过滤去渣即可制成成所述的用于治疗虚劳癥积所致白血病的中药复方制剂。
所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
本发明提供的用于治疗虚劳癥积所致白血病的中药复方制剂是采用水煮提取的方法来提取原料药物中的有效成分,并保持其活性,这样不仅可使药物中有效成分的溶出度大大提高,而且有助于药物的吸收,从而能够提高其生物利用度。另外,本发明的药物为纯中药复方制剂,因而患者长期服用后不会产生毒副作用,所以安全性好。此外,本发明的制备方法工艺简单,操作方便。
具体实施方式
白血病症状复杂,病程迁延,并发症较多。临床常见虚证、实证和虚实夹杂证等。此方立法于滋养***,化瘀解毒。方中生黄芪甘微温,健脾补中,升阳举陷,益卫固表,利尿,托毒生肌,为补中益气之要药,为君药。青蒿辛苦寒,清透虚热,凉血除蒸;炙鳖甲甘咸寒,滋阴潜阳,退热除蒸,软坚散结;三棱辛苦平,破血行气,消积止痛;半枝莲辛凉,清热解毒,利尿,消肿止痛,抗癌;山慈菇甘微辛凉,清热解毒,消痈散结;夏枯草辛苦寒,清热泻火,明目,散结消肿,以上诸药,清虚热,凉血解毒,利水消肿,共为臣药。秦艽辛苦平,祛风湿,通络止痛,退虚热,清湿热;生牡蛎咸微寒,潜阳补阴,软坚散结;莪术辛苦温,破血行气,消积止痛;白花蛇舌草微苦甘寒,清热解毒,利湿通淋;铁树叶甘酸微温,化瘀消肿,和胃散结;猫爪草甘辛微温,化痰散结,解毒消肿,以上诸药,祛风通络,利水渗湿,清虚热,解毒化痰消肿,为佐药。银柴胡甘微寒,清虚热,除疳热,引药入经,以为使药。本方养阴清热,解毒消肿,具有止痛、抗癌之功,故适用于虚劳癥积所致的白血病。
下面结合实施例对本发明提供的用于治疗白血病的中药复方制剂及其制备方法进行详细说明。
实施例1:
本实施例提供的用于治疗虚劳癥积所致白血病的中药复方制剂由用量为重量比的下列药物原料制成:
所述的用于治疗虚劳癥积所致白血病的中药复方制剂的制备方法是按照下列步骤顺序进行∶
(a)将炙鳖甲和生牡蛎按照配比进行称量并混合,然后加水煎煮一次30分钟而制成炙鳖甲和生牡蛎煎煮液;
(b)将上述药物原料中除炙鳖甲和生牡蛎之外的其它药物原料按照配比进行称量并混合,然后加水浸泡25分钟,再将步骤(a)中的炙鳖甲和生牡蛎及其煎煮液加入混合,煎煮30分钟,过滤去渣即可制成成所述的用于治疗虚劳癥积所致白血病的中药复方制剂。
所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
实施例2:
本实施例提供的用于治疗虚劳癥积所致白血病的中药复方制剂由用量为重量比的下列药物原料制成:
制备方法同实施例1。
实施例3:
本实施例提供的用于治疗虚劳癥积所致白血病的中药复方制剂由用量为重量比的下列药物原料制成:
制备方法同实施例1。
本发明提供的用于治疗虚劳癥积所致白血病的中药复方制剂呈棕色至棕褐色;气淡,味微苦。为了验证该中药复方制剂的治疗效果,本发明人利用上述中药复方制剂对301例患有虚劳癥积型白血病的患者进行了***临床观察,其中21-30岁患者80例,31-40岁115例,41-50岁106例,每次用药150ml,每日3次,120天为1个疗程。经1个疗程治疗后共治愈(血常规检查正常,骨髓象检查正常,染色体检查正常,主要症状明显改善)7例,占2.3%;有效(各项化验检查明显改善,主要症状有改善)133例,占44.2%;无效(各项化验检查无变化,主要症状无改善)161例,占53.5%;总有效率为46.5%。经2个疗程治疗后共治愈13例,占4.3%;有效211例,占70.1%;无效77例,占25.6%;总有效率为74.4%。
同时,本发明人对治疗效果与年龄、治疗效果与疗程之间的关系进行了分析,分析结果分别见表1、表2。
表1:本发明提供的中药复方制剂治疗效果与年龄关系表
将上述表1中的数据用x2检验法进行计算,结果为0.050>P>0.025,由此可以证明服用本发明提供的中药复方制剂来治疗虚劳癥积型白血病,对各年龄组的治疗效果不随年龄而变化。
表2:本发明提供的中药复方制剂治疗效果与疗程关系表
将上述表2中的数据用x2检验法进行计算,结果为P<0.005,由此可以证明服用本发明提供的中药复方制剂来治疗虚劳癥积型白血病,随着治疗的深入,治愈率、有效率均明显提高。
Claims (3)
1.一种用于治疗虚劳癥积所致白血病的中药复方制剂,其特征在于:所述的用于治疗虚劳癥积所致白血病的中药复方制剂由用量为重量比的下列药物原料制成:
生黄芪18—48 青蒿6—15 秦艽6—15 炙鳖甲18—48 生牡蛎18—48
三棱9—24 莪术9—24 半枝莲9—24 白花蛇舌草9—24 山慈菇6—15
铁树叶6—15 夏枯草18—48 猫爪草9—24 银柴胡4—10。
2.一种如权利要求1所述的用于治疗虚劳癥积所致白血病的中药复方制剂的制备方法,其特征在于:所述的制备方法是按照下列步骤顺序进行∶
(a)将炙鳖甲和生牡蛎按照配比进行称量并混合,然后加水煎煮一次30分钟而制成炙鳖甲和生牡蛎煎煮液;
(b)将上述药物原料中除炙鳖甲和生牡蛎之外的其它药物原料按照配比进行称量并混合,然后加水浸泡25分钟,再将步骤(a)中的炙鳖甲和生牡蛎及其煎煮液加入混合,煎煮30分钟,过滤去渣即可制成所述的用于治疗虚劳癥积所致白血病的中药复方制剂。
3.根据权利要求2所述的制备方法,其特征在于:所述的中药复方制剂与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂或膏剂。
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