CN106924483B - 用于治疗脾肾阳虚所致白血病的中药复方制剂及制备方法 - Google Patents

用于治疗脾肾阳虚所致白血病的中药复方制剂及制备方法 Download PDF

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CN106924483B
CN106924483B CN201710206804.0A CN201710206804A CN106924483B CN 106924483 B CN106924483 B CN 106924483B CN 201710206804 A CN201710206804 A CN 201710206804A CN 106924483 B CN106924483 B CN 106924483B
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马力
王维蔚
齐燕松
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Tianjin Shanji Hongxing Technology Development Co ltd
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Abstract

一种用于治疗脾肾阳虚所致白血病的复方制剂及制备方法。制剂由用量为重量比的下列药物原料制成：炙黄芪18—48、炒白术9—24、茯苓9—24、熟地黄18—48、炒白芍9—24、山药9—24、山茱萸6—15、菟丝子18—48、炒杜仲9—24、巴戟天9—24、淫羊藿9—24、制附子4—10、肉桂2—5、怀牛膝9—24。本发明制剂是采用水煮提取的方法来提取原料药物中的有效成分，并保持其活性，这样不仅可使药物中有效成分的溶出度大大提高，且有助于药物的吸收，从而能提高其生物利用度。另外，药物为纯中药复方制剂，因而患者长期服用后不会产生毒副作用，所以安全性好。此外，本发明的制备方法工艺简单，操作方便。

Description

用于治疗脾肾阳虚所致白血病的中药复方制剂及制备方法
技术领域
本发明涉及一种中药制剂及其制备方法，特别是涉及一种以中药为原料制成的用于治疗脾肾阳虚所致白血病的复方制剂及制备方法。
背景技术
白血病又称血癌，是由于正气内虚、温热毒邪乘虚而入引起的，以热毒、血瘀、痰浊互结，人体伤血为基本病机，以发热、出血、贫血及肝、脾、***肿大等为主要临床表现的一种造血***的恶性肿瘤。虽然目前临床上用于治疗白血病的药物品种很多，但针对性不强，而且部分药物的毒副作用大，所以服用后对于治疗属于脾肾阳虚所致的白血病这种疾病来说效果不明显。
发明内容
为了解决上述问题，本发明的目的在于提供一种用于治疗脾肾阳虚所致白血病的复方制剂及制备方法。
为了达到上述目的，本发明提供的用于治疗脾肾阳虚所致白血病的复方制剂由用量为重量比的下列药物原料制成：
炙黄芪18—48 炒白术9—24 茯苓9—24 熟地黄18—48 炒白芍9—24
山药9—24 山茱萸6—15 菟丝子18—48 炒杜仲9—24 巴戟天9—24
淫羊藿9—24 制附子4—10 肉桂2—5 怀牛膝9—24
所述的用于治疗脾肾阳虚所致白血病的中药复方制剂的制备方法是将上述药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣即可制成所述的用于治疗脾肾阳虚所致白血病的复方制剂。
所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
本发明提供的用于治疗脾肾阳虚所致白血病的中药复方制剂是采用水煮提取的方法来提取原料药物中的有效成分，并保持其活性，这样不仅可使药物中有效成分的溶出度大大提高，而且有助于药物的吸收，从而能够提高其生物利用度。另外，本发明的药物为纯中药复方制剂，因而患者长期服用后不会产生毒副作用，所以安全性好。此外，本发明的制备方法工艺简单，操作方便。
具体实施方式
白血病症状复杂，病程迁延，并发症较多。临床常见虚证、实证和虚实夹杂证等。此方立法于滋补肝肾，清热解毒。方中炙黄芪甘微温，健脾补中，升阳举陷，益卫固表，托毒生肌，为补中益气之要药，故为君药。炒白术甘苦温，益气健脾，燥湿利尿，为补气健脾第一要药；熟地黄甘微温，补血养阴，填精益髓；山药甘平，补脾养胃，为慢性久病调补脾胃之佳品；菟丝子辛甘平，补肾益精，养肝明目，止泻；巴戟天辛甘微温，补肾助阳，祛风除湿；制附子辛甘大热，回阳救逆，补火助阳，散寒止痛，为回阳救逆第一药，以上诸药，益气健脾，补肾填精，补血养阴，共为臣药。茯苓甘淡平，利水渗湿，健脾化痰，宁心安神；炒白芍苦酸微寒，养血敛阴，柔肝止痛，平抑肝阳；山茱萸酸涩微温，补益肝肾，收敛固涩，为平补阴阳之要药；炒杜仲甘温，补肝肾，强筋骨；淫羊藿辛甘温，补肾壮阳，祛风除湿；肉桂辛甘大热，补火助阳，散寒止痛，温经通脉，为治命门火衰之要药，以上诸药，健脾柔肝，收敛固涩，补益阴阳，共为佐药。怀牛膝苦甘酸平，活血通经，补肝肾，强筋骨，利水通淋，引火(血)下行，以为使药。本方滋补肝肾，同时具有清虚热，平阴阳之效，故适用于脾肾阳虚所致的白血病。
下面结合实施例对本发明提供的用于治疗白血病的中药复方制剂及其制备方法进行详细说明。
实施例1：
本实施例提供的用于治疗白血病的中药复方制剂由用量为重量比的下列药物原料制成：
Figure BDA0001260028180000021
Figure BDA0001260028180000031
所述的用于治疗脾肾阳虚所致白血病的中药复方制剂的制备方法是将上述药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣即可制成所述的用于治疗脾肾阳虚所致白血病的复方制剂。
另外，所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
实施例2：
本实施例提供的用于治疗白血病的中药复方制剂由用量为重量比的下列药物原料制成：
Figure BDA0001260028180000032
制备方法同实施例1。
实施例3：
本实施例提供的用于治疗白血病的中药复方制剂由用量为重量比的下列药物原料制成：
Figure BDA0001260028180000033
制备方法同实施例1。
本发明提供的用于治疗脾肾阳虚所致白血病的中药复方制剂呈棕色至棕褐色；气淡，味微苦。为了验证该中药复方制剂的治疗效果，本发明人利用上述中药复方制剂对291例患有脾肾阳虚型白血病的患者进行了***临床观察，其中21-30岁患者62例，31-40岁105例，41-50岁124例,每次用药150ml，每日3次，120天为1个疗程。经1个疗程治疗后共治愈(血常规检查正常，骨髓象检查正常，染色体检查正常，主要症状明显改善)7例，占2.4％；有效(各项化验检查明显改善，主要症状有改善)141例，占48.5％；无效(各项化验检查无变化，主要症状无改善)143例，占49.1％；总有效率为50.9％。经2个疗程治疗后共治愈10例，占3.4％；有效193例，占66.3％；无效88例，占30.2％；总有效率为69.8％。
同时，本发明人对治疗效果与年龄、治疗效果与疗程之间的关系进行了分析，分析结果分别见表1、表2。
表1：本发明提供的中药复方制剂治疗效果与年龄关系表
Figure BDA0001260028180000041
将上述表1中的数据用x2检验法进行计算，结果为0.050＞P＞0.025，由此可以证明服用本发明提供的中药复方制剂来治疗脾肾阳虚型白血病，对各年龄组的治疗效果不随年龄而变化。
表2：本发明提供的中药复方制剂治疗效果与疗程关系表
Figure BDA0001260028180000042
将上述表2中的数据用x2检验法进行计算，结果为P＜0.005，由此可以证明服用本发明提供的中药复方制剂来治疗脾肾阳虚型白血病，随着治疗的深入，治愈率、有效率均明显提高。

Claims (3)

1.一种用于治疗脾肾阳虚所致白血病的复方制剂，其特征在于：所述的复方制剂由用量为重量比的下列药物原料制成：
炙黄芪18—48 炒白术9—24 茯苓9—24 熟地黄18—48 炒白芍9—24
山药9—24 山茱萸6—15 菟丝子18—48 炒杜仲9—24 巴戟天9—24
淫羊藿9—24 制附子4—10 肉桂2—5 怀牛膝9—24。
2.一种用于治疗脾肾阳虚所致白血病的复方制剂的制备方法，其特征在于：所述的制备方法是将权利要求1所述的药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣即可制成所述的用于治疗脾肾阳虚所致白血病的复方制剂。
3.根据权利要求2所述的制备方法，其特征在于：所述的中药复方制剂与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂或膏剂。
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