CN106955384A - A kind of circulating tumor cell capturing device - Google Patents
A kind of circulating tumor cell capturing device Download PDFInfo
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- CN106955384A CN106955384A CN201710308520.2A CN201710308520A CN106955384A CN 106955384 A CN106955384 A CN 106955384A CN 201710308520 A CN201710308520 A CN 201710308520A CN 106955384 A CN106955384 A CN 106955384A
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- tumor cell
- circulating tumor
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- blood
- capturing device
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- 239000008280 blood Substances 0.000 claims description 42
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- 229960002897 heparin Drugs 0.000 claims description 15
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- 239000012621 metal-organic framework Substances 0.000 claims description 4
- -1 ErbB1 Proteins 0.000 claims description 3
- 206010034972 Photosensitivity reaction Diseases 0.000 claims description 3
- 102000052575 Proto-Oncogene Human genes 0.000 claims description 3
- 108700020978 Proto-Oncogene Proteins 0.000 claims description 3
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 3
- 239000010931 gold Substances 0.000 claims description 3
- 229910052737 gold Inorganic materials 0.000 claims description 3
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- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/362—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits changing physical properties of target cells by binding them to added particles to facilitate their subsequent separation from other cells, e.g. immunoaffinity
Abstract
The invention discloses a kind of circulating tumor cell capturing device, the container of circulating tumor cell is collected including one or more processing, container inner wall has been fitted together to the antibody that can be specifically bound with circulating tumor cell, or has been fitted together to surface modification and has the nano particle of antibody；Container is screw type container or the straight barrel type containing helicitic texture, can make the liquid inside inflow container that spiral advance is presented, and then produce centrifugal force；Circulating tumor cell can produce bigger centrifugal force relative to red blood cell, blood platelet, and then be specifically bound with the antibody on chamber wall.Two kinds of principles are combined, and can not only realize the capture to whole body CTC, reduce the probability of metastases；The CTC being enriched on container inner wall can be collected simultaneously, so as to its further sign and research.
Description
Technical field
The present invention relates to a kind of circulating tumor cell capturing device, belong to medicine instrument technical field.
Background technology
After tumour is the disease for being difficult in present illness capture, and tumour is shifted, the survival rate of patient is even more big
Big reduction.The process of metastases is extremely complex, to the circulating tumor cell in blood（CTC）, miRNA, the detection of excretion body
With certain reference value.CTC occurs transfer to tumour and plays vital effect as the pioneer official of transfer.
Have at present based on cell size and surface antibody principle, the CTC numbers in a small amount of blood of vitro detection, to patient's
Certain reference value is played in treatment and prognosis.But because vitro detection volume is less, it is impossible to which the tumour cell of whole body is carried out
, easily there is error, it is necessary to repeatedly determine, and can not play therapeutic action in detection.
In order to remove the circulating tumor cell in blood samples of patients comprehensively, prevent that tumour from occurring far-end transfer, it is necessary to research and develop one
Plant circulating tumor cell capturing device.
The content of the invention
Purpose：In order to overcome the deficiencies in the prior art, the present invention provides a kind of circulating tumor cell capturing device,
The blood of patient can be drawn after extracorporeal circulation apparatus, capture circulating tumor cell, the blood of purification is transmitted back to human body blood
Liquid is circulated, can replace/existing chemotherapy or radiotherapy clinically is aided in, tumour far-end transfer probability is effectively reduced,
The injury to patient is reduced, patient's cure rate is improved.Meanwhile, it is capable to circulating tumor cell CTC is collected into from chamber wall, to suffering from
The diagnosis and treatment of person is respectively provided with guiding significance.
Technical scheme：In order to solve the above technical problems, the technical solution adopted by the present invention is：
A kind of circulating tumor cell capturing device, it is characterised in that：Circulating tumor cell is collected including one or more processing
Container,
The container inner wall has been fitted together to the antibody that can be specifically bound with circulating tumor cell, or has been fitted together to surface and repaiies
It is decorated with the nano particle of the antibody；The antibody is circulating tumor cell CTC specific antibody, and preferably anti-epithelial cell glues
Attached albumen（EpCAM）, cytokeratin (cytokeratin, CK), VEGF（vascular
endothelial growth factor, VEGF）, ErbB1（epidermal growth factor
receptor, EGFR）, proto-oncogene ErbB-2（human epidermal growth factor
receptor-2, HER2）One or more in antibody；
The container is screw type container or the straight barrel type containing helicitic texture, can make the liquid inside inflow container that spiral shell is presented
It is rotating to advance, and then produce centrifugal force；Circulating tumor cell can produce bigger centrifugal force relative to red blood cell, blood platelet,
And then specifically bound with the antibody on chamber wall.
Preferably, described circulating tumor cell capturing device, it is characterised in that：The container inner wall is carved with recessed
The screw thread of swaged or male-type.
It is used as another preferred scheme, described circulating tumor cell capturing device, it is characterised in that：The container is straight tube
Type container, helicitic texture be carved with the screw thread of umbilicate type or male-type for inwall or be placed with the container of straight barrel type one or
More than one screw rod or flight.
Preferably, described circulating tumor cell capturing device, it is characterised in that：The nano particle is received for magnetic
Rice grain, gold nano grain, nano SiO 2 particle, metal organic framework nano particle, polymer nano granules, albumen are received
One or more in rice grain, liposome.
Preferably, described circulating tumor cell capturing device, it is characterised in that：Contain on the nano particle
The connecting key of response fracture.
Further, described circulating tumor cell capturing device, it is characterised in that：The company of the response response fracture
It is redox response, pH responses or photosensitivity response to connect the response of key generation.
The present invention also provides a kind of circulating tumor cell dialysis treatment instrument, including arterial pressure table, blood pump, heparin pump,
Feed pressure table, off gas system, vein pressure table, also including the above-mentioned circulating tumor cell capturing device of claim 1 to 6,
Arterial pressure table, blood pump, heparin pump, feed pressure table, circulating tumor cell capturing device, off gas system, vein pressure table
It is sequentially connected by extracorporeal blood pipeline；Blood pump provides the power of extracorporeal circulation of blood；Heparin pump provides heparin to blood, prevents
Only occurs blood coagulation；Circulating tumor cell capturing device is used to capture circulating tumor cell；The blood of purification is arranged by off gas system
After bubble removing, it is transported to after vein pressure table detection blood is qualified in patient's body.
More specifically, described circulating tumor cell dialysis treatment instrument, it is characterised in that：The off gas system includes deflating
Valve and air monitor.
Beneficial effect：The circulating tumor cell capturing device that the present invention is provided, the straight tube of helicitic texture is contained using inwall
Type or screw type container, or the container containing screw rod or flight, make the out-of-date generation centrifugal force that can be vortexed of blood stream, resist
Original antibody is specifically bound；Two kinds of principles are combined, and can not only realize the capture to whole body CTC, reduce metastases
Probability；The CTC being enriched on container inner wall can be collected simultaneously, so as to its further sign and research.Energy
It is enough to suppress the diffusion of tumour cell in vivo well, can replace/existing chemotherapy or radiotherapy clinically is aided in,
Tumour far-end transfer probability is effectively reduced, the injury to patient is reduced, patient's cure rate is improved.Meanwhile, it is capable to from chamber wall
CTC is collected into, the diagnosis and treatment to patient are respectively provided with guiding significance.
Brief description of the drawings
Fig. 1 is the structural representation of circulating tumor cell dialysis treatment instrument（Arrow represents blood flow direction）；
Fig. 2 is the schematic diagram of screw type container circulating tumor cell capturing device;
Fig. 3 is the schematic diagram that inwall carves threaded straight barrel type container circulating tumor cell capturing device；
Fig. 4 is the schematic diagram for the circulating tumor cell capturing device that straight barrel type container is embedded in screw rod;
Fig. 5 is the schematic diagram for the circulating tumor cell capturing device that straight barrel type container is embedded in flight;
Fig. 6 is that blood flow advances in the container inner wall inside spin containing helicitic texture, specific antibody knot chimeric with its surface CTC
The schematic diagram of conjunction；
Label in figure：1 arterial pressure table, 2 blood pumps, 3 heparin pumps, 4 feed pressure tables, 5 circulating tumor cell capturing devices, 6
Off gas system, 7 vein pressure tables.
Embodiment
The present invention is further described with reference to specific embodiment.
As shown in Figures 2 to 5, a kind of circulating tumor cell capturing device, including one or more processing are collected circulation and swollen
The container of oncocyte, the container inner wall has been fitted together to the antibody that can be specifically bound with circulating tumor cell, Huo Zheqian
Having closed surface modification has the nano particle of the antibody.The antibody is anti-Epithelial Cell Adhesion albumen（EpCAM）, cytokeratin
(cytokeratin, CK), VEGF（vascular endothelial growth factor, VEGF）、
ErbB1（epidermal growth factor receptor, EGFR）, proto-oncogene human epidermal life
Growth factor receptor body 2（human epidermal growth factor receptor-2, HER2）One kind or several in antibody
Kind.
The nano particle is magnetic nano particle, gold nano grain, nano SiO 2 particle, metal organic framework
（MOF）One or more in nano particle, polymer nano granules, protein nano particle, liposome.Further, it is described
Containing on nano particle can be broken with response（Redox response, pH responses, photosensitivity response etc.）Connecting key.
Container can be screw type container or the container of straight barrel type；When for screw type container, container inner wall is carved with depression
The screw thread of type or male-type, as shown in Figure 2；Screw thread that can also be without umbilicate type or male-type, by screw type container in itself
Helical structure can also realize and make liquid inside inflow container that spiral advance is presented.
Another scheme, as shown in figure 3, when the container for straight barrel type, container inner wall is carved with umbilicate type or male-type
Screw thread.
Another preferred scheme, as shown in Figure 4 and Figure 5, when the container for straight barrel type, is placed in the container of straight barrel type
Appropriately sized screw rod or flight.
The circulating tumor cell capturing device of the present invention can make the liquid inside inflow container that spiral advance is presented, and enter
And produce centrifugal force；The larger circulating tumor cell of individual can produce bigger centrifugal force relative to red blood cell, blood platelet, enter
And specifically bound with the antibody on chamber wall.
As shown in figure 1, a kind of circulating tumor cell dialysis treatment instrument, including arterial pressure table 1, blood pump 2, heparin pump 3,
Feed pressure table 4, circulating tumor cell capturing device 5, off gas system（Vent valve and air monitor）6th, vein pressure table 7,
Arterial pressure table 1, blood pump 2, heparin pump 3, feed pressure table 4, circulating tumor cell capturing device 5, off gas system（Vent valve
And air monitor）6th, vein pressure table 7 is sequentially connected by extracorporeal blood pipeline, and outside is provided with casing.Wherein blood pump 2 is carried
Sanguimotor power outside donor；Heparin pump 3 provides heparin to blood, prevents blood coagulation；Circulating tumor cell capturing device 5
Circulating tumor cell can be captured；The blood of purification detects blood after off gas system 6 excludes bubble in vein pressure table 7
It is transported to after liquid is qualified in patient's body.Used unit and connecting pipe are medical grade.
Connecting pipe used, pressure gauge, blood pump in circulating tumor cell dialysis treatment instrument, it is conventional that heparin pump is medical treatment
Equipment.Circulating tumor cell capturing device 5 is made up of multiple screw types or straight barrel type container, and each container is respectively equipped with blood
Inflow entrance and flow export, and the inwall of each container contains helicitic texture.When blood flows through circulating tumor cell capturing device
When, the helicitic texture of container inner wall and（Or）The helical structure of container makes blood advance in container inside spin, and then can be with
The chimeric chamber wall for having CTC specific antibodies is fully contacted；Simultaneously because CTC volumes are larger, produced relatively under vortex conditions
Big centrifugal force, it is easier to which the CTC specific antibody chimeric with container inner wall is combined, as shown in fig. 6, and then by CTC from blood
Middle separation.The blood of patient carries out receiving after specially treated by after " dialysis ", CTC is remained on container inner wall to this container
Collect CTC cells, in order to the further research to CTC cells.
The present invention draws blood to be clean to capture circulating tumor cell device from human body artery blood vessel, sets angiosthenia
Power table monitors blood pressure；Heparin pump is flowed to by blood pump, occurs blood coagulation to prevent Hemostatic Oral Liquid；It is thin subsequently into capture circulating tumor
After the core apparatus of born of the same parents, using container inner wall helicitic texture and（Or）The helical structure of container, the blood spiral flowed through
Advance, and then can fully be contacted with the chimeric container inner wall for there are CTC specific antibodies；Simultaneously because CTC volumes are larger, it is being vortexed
Under the conditions of produce relatively large centrifugal force, it is easier to the CTC specific antibody chimeric with container inner wall is combined, and then by CTC
Separated from blood；The deaerated system of blood after final purification excludes bubble；Patient's body is returned to after the detection of vein pressure table
It is interior.The blood of patient collects CTC by after " dialysis ", CTC is remained on container inner wall after carrying out specially treated to this container
Cell, in order to the further research to CTC cells.The invention can replace/existing the chemotherapy or radiation clinically of auxiliary
Therapy, effectively reduces tumour far-end transfer probability, improves patient's cure rate.Meanwhile, it is capable to CTC is collected into from chamber wall, it is right
The diagnosis and treatment of patient is respectively provided with guiding significance.
The above is only the preferred embodiment of the present invention, it should be pointed out that：For the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (9)
1. a kind of circulating tumor cell capturing device, it is characterised in that：Circulating tumor cell is collected including one or more processing
Container,
The container inner wall has been fitted together to the antibody that can be specifically bound with circulating tumor cell, or has been fitted together to surface and repaiies
It is decorated with the nano particle of antibody；The antibody is the specific antibody of circulating tumor cell；
The container is screw type container or the straight barrel type containing helicitic texture, can make the liquid inside inflow container that spiral shell is presented
It is rotating to advance, and then produce centrifugal force；Circulating tumor cell can produce bigger centrifugal force relative to red blood cell, blood platelet,
And then specifically bound with the antibody on chamber wall.
2. circulating tumor cell capturing device according to claim 1, it is characterised in that：The antibody is anti-epithelial cell
Attachment proteins, cytokeratin, VEGF, ErbB1, proto-oncogene human epidermal growth because
One or more in the sub- antibody of acceptor 2.
3. circulating tumor cell capturing device according to claim 1, it is characterised in that：The container inner wall is carved with depression
The screw thread of type or male-type.
4. circulating tumor cell capturing device according to claim 1, it is characterised in that：The container holds for straight barrel type
Device, is placed with one or more screw rod or flight in the container of straight barrel type.
5. circulating tumor cell capturing device according to claim 1, it is characterised in that：The nano particle is magnetic nanometer
Particle, gold nano grain, nano SiO 2 particle, metal organic framework nano particle, polymer nano granules, protein nano
One or more in particle, liposome.
6. circulating tumor cell capturing device according to claim 1, it is characterised in that：Contain sound on the nano particle
The connecting key of answering property fracture.
7. circulating tumor cell capturing device according to claim 6, it is characterised in that：The response response fracture
The response that connecting key is produced is redox response, pH responses or photosensitivity are responded.
8. a kind of circulating tumor cell dialysis treatment instrument, including arterial pressure table, blood pump, heparin pump, feed pressure table, degasification
System, vein pressure table, it is characterised in that：Also include the circulating tumor cell capturing device described in claim any one of 1-7,
Arterial pressure table, blood pump, heparin pump, feed pressure table, circulating tumor cell capturing device, off gas system, vein pressure table
It is sequentially connected by extracorporeal blood pipeline；Blood pump provides the power of extracorporeal circulation of blood；Heparin pump provides heparin to blood, prevents
Only occurs blood coagulation；Circulating tumor cell capturing device is used to capture circulating tumor cell；The blood of purification is arranged by off gas system
After bubble removing, it is transported to after vein pressure table detection blood is qualified in patient's body.
9. circulating tumor cell dialysis treatment instrument according to claim 8, it is characterised in that：The off gas system includes putting
Air valve and air monitor.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710308520.2A CN106955384A (en) | 2017-05-04 | 2017-05-04 | A kind of circulating tumor cell capturing device |
| PCT/CN2018/082484 WO2018201862A1 (en) | 2017-05-04 | 2018-04-10 | Circulating tumor cell capture device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710308520.2A CN106955384A (en) | 2017-05-04 | 2017-05-04 | A kind of circulating tumor cell capturing device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106955384A true CN106955384A (en) | 2017-07-18 |
Family
ID=59482139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710308520.2A Pending CN106955384A (en) | 2017-05-04 | 2017-05-04 | A kind of circulating tumor cell capturing device |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN106955384A (en) |
| WO (1) | WO2018201862A1 (en) |
Cited By (7)
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| CN107488582A (en) * | 2017-08-08 | 2017-12-19 | 上海交通大学 | Micro fluidic device |
| CN108761080A (en) * | 2018-08-16 | 2018-11-06 | 中国科学院合肥物质科学研究院 | One specific cells in body captures box |
| WO2018201862A1 (en) * | 2017-05-04 | 2018-11-08 | 中国药科大学 | Circulating tumor cell capture device |
| CN108795692A (en) * | 2018-06-26 | 2018-11-13 | 成都普瑞康生物科技有限公司 | Rare cell capture systems and its application |
| CN111840658A (en) * | 2020-07-03 | 2020-10-30 | 深圳市人民医院 | Intravenous indwelling needle catheter and preparation method and application thereof |
| CN113101900A (en) * | 2021-03-15 | 2021-07-13 | 中国药科大学 | Hemoperfusion adsorbent for removing circulating tumor cells and preparation method thereof |
| CN114533995A (en) * | 2020-11-25 | 2022-05-27 | 北京大学 | In-vivo circulating tumor cell dialysis system |
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| CN108795692A (en) * | 2018-06-26 | 2018-11-13 | 成都普瑞康生物科技有限公司 | Rare cell capture systems and its application |
| CN108795692B (en) * | 2018-06-26 | 2021-01-01 | 成都普瑞康生物科技有限公司 | Rare cell capture system and application thereof |
| CN108761080A (en) * | 2018-08-16 | 2018-11-06 | 中国科学院合肥物质科学研究院 | One specific cells in body captures box |
| CN111840658A (en) * | 2020-07-03 | 2020-10-30 | 深圳市人民医院 | Intravenous indwelling needle catheter and preparation method and application thereof |
| CN114533995A (en) * | 2020-11-25 | 2022-05-27 | 北京大学 | In-vivo circulating tumor cell dialysis system |
| CN113101900A (en) * | 2021-03-15 | 2021-07-13 | 中国药科大学 | Hemoperfusion adsorbent for removing circulating tumor cells and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018201862A1 (en) | 2018-11-08 |
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Application publication date: 20170718 |