CN106943560A - Traditional Chinese medicine composition for clearing lung and nourishing lung as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for clearing lung and nourishing lung as well as preparation method and application thereof Download PDFInfo
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- CN106943560A CN106943560A CN201710128039.5A CN201710128039A CN106943560A CN 106943560 A CN106943560 A CN 106943560A CN 201710128039 A CN201710128039 A CN 201710128039A CN 106943560 A CN106943560 A CN 106943560A
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Abstract
The invention relates to the field of traditional Chinese medicine pharmacy, in particular to a traditional Chinese medicine composition for clearing lung and nourishing lung and a preparation method and application thereof. The composition comprises the following components: radix glehniae, loquat fruits, Chinese yam, reed rhizome, sea pine nuts, poria cocos, perilla leaves, dark plums, phyllanthus emblica, plantain seeds, sarcandra glabra, burdock, trichosanthes roots, blackberry lily, radix stemonae and aster. The composition is prepared according to the processes of acceptance, pretreatment, leaching, packaging, inspection and warehousing, and can be applied to disease prevention and treatment and health care of a respiratory system. The traditional Chinese medicine composition disclosed by the invention is scientific in compatibility, has a synergistic effect with various raw materials, is not added with any additive, has the effects of moistening lung, nourishing, refreshing, reducing pathogenic fire, promoting the production of body fluid, relieving restlessness, lowering blood pressure, resisting bacteria, diminishing inflammation and clearing away heat and toxic materials, can be used as a drink for long-term drinking, and can enhance immunity, regulate endocrine and prevent cardiovascular and cerebrovascular diseases; the lung can be cleaned by atomization and cleaning through an atomizer; convenient to use, the simple operation.
Description
Technical field
The present invention relates to field of traditional Chinese medicine pharmacy, and in particular to a kind of clearing lung-heat support lung Chinese medicine composition and preparation method thereof and
Using.
Background technology
With developing rapidly for industry, air pollution is increasingly serious, there is thousands of virus and disease in contaminated air
Bacterium, damages our life and health, such as:Industrial waste gas, vehicle exhaust, carbon dioxide, formaldehyde, second-hand-cigarette etc. all exist daily
Our lung is attacked, the healthy main source of life is simultaneously maintained at cardio-pulmonary function.Daily breathing let us suction is substantial amounts of
Rubbish toxin, it is to breathe to produce reaction at the cilium and mucous membrane on respiratory tract top layer when these rubbish toxin enter in respiratory tract
Road formation nasal mucus, in lower respiratory tract formation phlegm, when the mucous membrane of people and the function of cilium come to harm, be immunized and cleaning capacity under
Drop causes these toxin to excrete, so as to cause the various problems of respiratory tract, such as:Nasopharyngitis, flu, bronchus
Inflammation, pneumonia, abscess of throat, asthma even lung cancer.In life, majority are ill ability hospital treatments, often miss disease
The golden hour of disease, thus it is long-term live under haze or long-term smoking people, in early stage, essence does not occur also for lung
Venereal disease takes maintenance hygienic measures to be even more important when becoming.In the market there is also a small number of health beverages, but because component prescription
It is unreasonable, and processing technology imperfection, cause the medical value and nutritive value of product not high, or even medicine after compatibility occur
Effect does not increase anti-situation about subtracting.
It can be seen that also there is larger deficiency in prior art.
The content of the invention
In view of this, it is necessary to for it is above-mentioned the problem of there is provided a kind of clearing lung-heat support lung Chinese medicine composition and its preparation side
There is method and application, Chinese medicine composition of the invention clearing lung-heat to support lung, the removing for lifting respiratory system and the effect of defence capability, and
One-object-many-purposes, simple operation.
To reach above-mentioned purpose, the present invention uses following technical scheme:
The Chinese medicine composition of lung, including component are supported in a kind of clearing lung-heat:5-12 parts of radix glehniae, Loquat-Shaped Cake 5-12 parts, Chinese yam 15-30
Part, 15-30 parts of reed rhizome, 5-10 parts of korean pine seed, 10-15 parts of Poria cocos, 5-9 parts of perilla leaf, 6-12 parts of dark plum, 3-9 parts of emblic, Chinese herbaceous peony
It is sub- 5-10 parts, 9-15 parts of Chloranthus glaber, 5-10 parts of great burdock achene, 10-15 parts of root of Chinese trichosanthes, 3-10 parts of blackberry lily, 3-9 parts of the tuber of stemona, aster
2.5-15 parts.
Further, the composition includes:7-10 parts of radix glehniae, Loquat-Shaped Cake 7-10 parts, 19-26 parts of Chinese yam, reed rhizome 19-
26 parts, 6-9 parts of korean pine seed, 11-14 parts of Poria cocos, 6-8 parts of perilla leaf, 8-11 parts of dark plum, 5-8 parts of emblic, 6-9 parts of plantain seed, grass
11-14 parts of coral, 6-9 parts of great burdock achene, 11-14 parts of root of Chinese trichosanthes, 5-8 parts of blackberry lily, 5-8 parts of the tuber of stemona, 6-12 parts of aster.
Further, the composition includes:8.5 parts of radix glehniae, 8.5 parts of Loquat-Shaped Cake, 22.5 parts of Chinese yam, reed rhizome 22.5
Part, 7.5 parts of korean pine seed, 12.5 parts of Poria cocos, 7 parts of perilla leaf, 9 parts of dark plum, 6 parts of emblic, 7.5 parts of plantain seed, 12 parts of Chloranthus glaber, ox
7.5 parts of burdock, 12.5 parts of root of Chinese trichosanthes, 6.5 parts of blackberry lily, 6 parts of the tuber of stemona, 8.7 parts of aster.
The present invention also provides a kind of preparation method of the atomized liquid for the Chinese medicine composition that lung is supported in clearing lung-heat, and step includes:
(1) check and accept:Under the conditions of 100,000 grades of clean areas, raw material is carried out by beverage processing raw material acceptance criteria;
(2) pre-process:By radix glehniae, Loquat-Shaped Cake, Chinese yam, reed rhizome, korean pine seed, Poria cocos, perilla leaf, dark plum, emblic, Chinese herbaceous peony
Son, Chloranthus glaber, great burdock achene, root of Chinese trichosanthes, blackberry lily, the tuber of stemona, aster carry out ultramicro grinding and cross 2000 mesh sieves, standby;
(3) extract:According to each component mass fraction by pretreated radix glehniae, Loquat-Shaped Cake, Chinese yam, reed rhizome, korean pine seed,
Poria cocos, perilla leaf, dark plum, emblic, plantain seed, great burdock achene, root of Chinese trichosanthes, blackberry lily, the tuber of stemona, aster, which add water, carries out decoction extraction, decocts
Extraction 1.8-2.2h is boiled, is decocted after extraction, Chloranthus glaber is added and carries out boiling extraction 10-20min, repeats to decoct leaching process 2
It is secondary, after terminating, cryogenic vacuum concentration is carried out after centrifugal filtration, drink concentrate is produced, stored standby into medicine storing pot;
(4) pack:Drink concentrate is diluted and aseptic packaging;
(5) examine:According to GB7101-2015《National food safety standard:Beverage》And GB/T4789.24-2003《Food
Sanitary microorganism is examined》It is sampled inspection;
(6) be put in storage:Qualified product will be examined to be housed in relative humidity≤30%, oxygen concentration≤5%, 4 DEG C of temperature
Under the conditions of.
Further, extraction 2.0h is decocted in the step (3).
Further, Chloranthus glaber is added in the step (3) and carries out boiling extraction 15min.
Further, composition made from the Chinese medicine composition or the preparation method is applied to the disease of respiratory system
Preventing and treating and health care.
Beneficial effect of the present invention:
Radix glehniae:Cold nature, sweet, slight bitter.Nourishiing yin to clear away the lung-heat, reinforcing stomach reg fluid, expelling phlegm and arresting coughing.Lung-heat type cough is controlled, consumptive disease is long
Cough, deficiency of stomach-Yin, it is impairment of yin dry throat, thirsty.
Loquat-Shaped Cake:It is sweet sour, mild-natured;Enter lung, stomach.It can moisten the lung and relieve the cough, promote the production of body fluid to quench thirst, harmonizing stomach and lowering adverse Qi.It is mainly used in controlling
Treat lung heat and cough, chronic cough be not cured, the illness such as dry throat and mouth and stomach unsaturated vapor.《This is through meeting original》:Must be extremely ripe, it is to have the lower gas that quenches the thirst
The work(of moisturizing viscera.If sour with life, power can help liver to cut down spleen, and food makes swelling of REN ZHONG diarrhea.Meng's numerous:Relieving the five internal organs.Cui Yuxi《Cuisine canon》:
Lower gas, only the sound of vomiting vomit it is inverse.《Solar corona》:Lung qi is controlled, moisturizing viscera, lower gas, preventing or arresting vomiting is inverse, and thirsty disease.《The southern regions of the Yunnan Province book on Chinese herbal medicine》:Control consumptive lung disease consumptive disease wound
Spit blood, cough is spat, croup.Child convulsion heating is controlled again.
Chinese yam:Gan Ping, it is nontoxic, enter spleen and lung kidney channel.Nourishing kidney and replenishing pneuma, benefit lung and restrain cough.《Compendium of Materia Medica》:Chinese yam controls all empty hundred
Damage, treat general debility, decaptitate seborrheic dematitis, only pain in the back, relieving restlessness heat, kidney-nourishing gas, strengthening the spleen and stomach.《Japan hanako materia medica》:Help the five internal organs, control muscle
Bone, long will to calm the nerves cure mainly and let out smart forgetful.《Sheng Nong's herbal classic》:Main strong middle qi-restoratives, tonifying middle-Jiao and Qi power.
Reed rhizome, nature and flavor are sweet, tremble with fear, with clearing heat and promoting fluid, relieving restlessness, preventing or arresting vomiting, effect of diuresis, and for pyreticosis polydipsia, stomach energy is vomitted
The sound of vomiting, cough with lung heat, lung carbuncle pyemesis, puckery pain of heat gonorrhea.
Korean pine seed:It is warm-natured, sweet, enter liver, lung, large intestine channel.Korean pine seed contains fat oil and (74% is accounted for, wherein with oleic acid
Based on ester, linoleic acid fat), protein, volatile oil, sugar, phosphorus, iron, calcium etc..Main toxin expelling effect of korean pine seed is to remove lung
Toxin, can enriching yin, moistening lung, cough-relieving, dispelling wind and removing obstruction in the meridians, dispelling cold and removing dampness, replenishing blood and nourishing liver, nourishing and suppressing Yang, blood-enrich.
Poria cocos:Clearing damp and promoting diuresis, invigorating the spleen, calming heart.For oedema oliguria, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, the mind
Uneasiness, insomnia of palpitating with fear.
Perilla leaf:Pungent, tepor is nontoxic, returns spleen, lung channel.Push away old temperature agent, light diaphoretic prescription.Therefore person under main gas, it can be allowed to declare
Person on hair, gas, can be allowed to a surname and take the photograph, be the god's medicine for controlling gas, can dissipate the heresy of blood vessels.Expelling cold and relieving exterior syndrome, regulating the flow of QI to ease the stomach.For chill sense
Emit, have a headache, cough, fullness and oppression of chest and abdomen.
Dark plum:It is sour, puckery, it is mild-natured.Return liver, spleen, lung, large intestine channel.Astringe the lung, puckery intestines promote the production of body fluid, claming ascaris.For chronic cough of deficiency lung,
Protracted dysentery and diarrhea, abnormal heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache.
Emblic:It is sweet, sour, puckery, it is cool.Attach to the lung and stomach meridians.Clearing heat and cooling blood, food digesting stomach fortifying, cough-relieving of promoting the production of body fluid.Blood-head blood stasis is cured mainly,
Indigestion, abdominal distension is coughed, laryngalgia, dry.
Plantain seed:It is sweet in flavor and cold in property, enter kidney, bladder, liver, lung channel, function promoting diuresis for stranguria, excreting dampness antidiarrheal, clear liver and improve vision, heat-clearing
Resolving sputum.
Chloranthus glaber:It is bitter in taste, pungent, flat.Thoughts of returning home warp, Liver Channel.Can anti-inflammation, dispelling wind and eliminating dampness, promoting blood circulation and stopping pain.
Great burdock achene:It is pungent, bitter, cold in nature.Attach to the lung and stomach meridians.Dispelling wind and heat from the body, clearing heat and detoxicating promoting eruption, facilitaing lung relieving sore-throat dissipates swollen.For
Anemopyretic cold, warm disease are from the beginning of wind-heat or cough with lung heat, coughing up phlegm not smooth, abscess of throat, macula is impermeable, measles initial stage, rash goes out not smooth
And rubella itch, sore swollen toxin and mumps etc..Raw use can relax bowel, and heat toxin red swelling and pain of throat has constipation with heat retention concurrently especially suitable.
Root of Chinese trichosanthes:Sweet, slight bitter, is slightly cold.Attach to the lung and stomach meridians.Can heat-clearing life Jian, dry moistening lung, fall fire controls cough, and wash phlegm knot is sharp
Throat, only quenches one's thirst, with controlling abscess of throat caused by heat toxin.
Blackberry lily:Bitter, cold in nature, micro- poison.Return lung is passed through.Can clearing heat and detoxicating, dissipating bind anti-inflammatory, swelling and pain relieving, relieving cough and reducing sputum, be used for
Accumulation and obstruction of sputum, the disease such as cough and asthma.Abscess of throat, larynx numbness is obstructed, constipation and anuresis, and all medicines are not imitated, belly ponding, and skin blacks,
Acute mastitis from the beginning of.
The tuber of stemona:Sweet, hardship, tepor.Return lung is passed through.Can moistening lung to lower qi cough-relieving, desinsection.Coughed for new chronic cough, pulmonary tuberculosis cough, hundred
Day is coughed;Outside for head louse, body louse, enterobiasis, private parts, which is disturbed, itches.The sweet tuber of stemona moistens the lung and relieve the cough.For deficiency of Yin overstrain cough.
Aster:Bitter, temperature.Warm lung, lower gas, dissolving phlegm, cough-relieving.Cough due to wind-cold evil's asthma is controlled, consumptive disease coughs vomiting of pus and blood, and larynx numbness is small
Just it is unfavorable.
The present composition is by above-mentioned drug matching, and comprehensive clearing lung-heat moistening lung, clearing damp row carbuncle, the effect such as help of detoxifying are lifted
Itself the removing repair function and resistance of respiratory system or even whole body, it is with strong points, it is safe, except being used as treatment
Outside medication, health care or prophylactic are alternatively arranged as, it is ensured that family circle's is healthy.
Atomized liquid can be made in the present composition, using equipment such as humidifier, atomization instrument, air filters, be in
Can to use, and can many people use simultaneously.The present composition also can directly be drunk as drink, and adhering to drinking for a long time can
Strengthen immunity, regulation endocrine, prevention cardiovascular and cerebrovascular disease, carry out being atomized clear suction, for present haze by atomizer
Serious can clearing lung-heat cleaning lung.
The advantage of product of the present invention is the synergy each other of scientific compatibility and plurality of raw materials, is added without any
Plus agent, with moistening lung nourishing, pure and fresh fall fire, relieving restlessness of promoting the production of body fluid, hypotensive, anti-inflammation, it is clearing heat and detoxicating the effect of, for present
The function that the influence of haze seriously can reach and remove lung's endotoxin rubbish, repairs damaged tissues and cell, long-term use can increase
Strong immunity, regulation endocrine, prevention cardiovascular and cerebrovascular disease, removing and repairing effect to slight Pneumoconiosis Patients lung also show
Write.
Embodiment
In order to which problem solved by the invention, the technical scheme used and the effect reached is better described, now tie
Close specific embodiment and related data is expanded on further.It should be noted that present invention is implemented including but not limited to following
Example and combinations thereof embodiment.
The Chinese medicine composition of lung is supported in a kind of clearing lung-heat of embodiment 1
Including component:5 parts of radix glehniae, 12 parts of Loquat-Shaped Cake, 19 parts of Chinese yam, 26 parts of reed rhizome, 5 parts of korean pine seed, 15 parts of Poria cocos, Soviet Union
9 parts of leaf, 11 parts of dark plum, 3 parts of emblic, 5 parts of plantain seed, 11 parts of Chloranthus glaber, 10 parts of great burdock achene, 10 parts of root of Chinese trichosanthes, 8 parts of blackberry lily,
9 parts of the tuber of stemona, 6 parts of aster.
Preparation method:
(1) check and accept:Under the conditions of 100,000 grades of clean areas, raw material is carried out by beverage processing raw material acceptance criteria;
(2) pre-process:By radix glehniae, Loquat-Shaped Cake, Chinese yam, reed rhizome, korean pine seed, Poria cocos, perilla leaf, dark plum, emblic, Chinese herbaceous peony
Son, Chloranthus glaber, great burdock achene, root of Chinese trichosanthes, blackberry lily, the tuber of stemona, aster carry out ultramicro grinding and cross 2000 mesh sieves, standby;
(3) extract:By pretreated radix glehniae, Loquat-Shaped Cake, Chinese yam, reed rhizome, korean pine seed, Poria cocos, perilla leaf, dark plum, remaining
Gan Zi, plantain seed, great burdock achene, root of Chinese trichosanthes, blackberry lily, the tuber of stemona, aster, which add water, carries out decoction extraction, decocts extraction 1.8h, decocts leaching
After carrying, Chloranthus glaber is added and carries out boiling extraction 10min, repeats to decoct leaching process 2 times, after terminating, is carried out after centrifugal filtration
Cryogenic vacuum is concentrated, and produces drink concentrate, is stored standby into medicine storing pot;
(4) pack:Drink concentrate is diluted and aseptic packaging;
(5) examine:According to GB7101-2015《National food safety standard:Beverage》And GB/T4789.24-2003《Food
Sanitary microorganism is examined》It is sampled inspection;
(6) be put in storage:Qualified product will be examined to be housed in relative humidity≤30%, oxygen concentration≤5%, 4 DEG C of temperature
Under the conditions of.
The Chinese medicine composition of lung is supported in a kind of clearing lung-heat of embodiment 2
Including component:12 parts of radix glehniae, 5 parts of Loquat-Shaped Cake, 26 parts of Chinese yam, 19 parts of reed rhizome, 10 parts of korean pine seed, 10 parts of Poria cocos,
5 parts of perilla leaf, 8 parts of dark plum, 9 parts of emblic, 10 parts of plantain seed, 15 parts of Chloranthus glaber, 5 parts of great burdock achene, 15 parts of root of Chinese trichosanthes, 3 parts of blackberry lily,
3 parts of the tuber of stemona, 15 parts of aster.
Preparation method is same as Example 1.
The Chinese medicine composition of lung is supported in a kind of clearing lung-heat of embodiment 3
Including component:10 parts of radix glehniae, 7 parts of Loquat-Shaped Cake, 15 parts of Chinese yam, 30 parts of reed rhizome, 6 parts of korean pine seed, 11 parts of Poria cocos, Soviet Union
6 parts of leaf, 6 parts of dark plum, 5 parts of emblic, 9 parts of plantain seed, 14 parts of Chloranthus glaber, 9 parts of great burdock achene, 14 parts of root of Chinese trichosanthes, 5 parts of blackberry lily, hundred
8 parts of portion, 12 parts of aster.
Preparation method:
(1) check and accept:Under the conditions of 100,000 grades of clean areas, raw material is carried out by beverage processing raw material acceptance criteria;
(2) pre-process:By radix glehniae, Loquat-Shaped Cake, Chinese yam, reed rhizome, korean pine seed, Poria cocos, perilla leaf, dark plum, emblic, Chinese herbaceous peony
Son, Chloranthus glaber, great burdock achene, root of Chinese trichosanthes, blackberry lily, the tuber of stemona, aster carry out ultramicro grinding and cross 2000 mesh sieves, standby;
(3) extract:By pretreated radix glehniae, Loquat-Shaped Cake, Chinese yam, reed rhizome, korean pine seed, Poria cocos, perilla leaf, dark plum, remaining
Gan Zi, plantain seed, great burdock achene, root of Chinese trichosanthes, blackberry lily, the tuber of stemona, aster, which add water, carries out decoction extraction, decocts extraction 2.0h, decocts leaching
After carrying, Chloranthus glaber is added and carries out boiling extraction 15min, repeats to decoct leaching process 2 times, after terminating, is carried out after centrifugal filtration
Cryogenic vacuum is concentrated, and produces drink concentrate, is stored standby into medicine storing pot;
(4) pack:Drink concentrate is diluted and aseptic packaging;
(5) examine:According to GB7101-2015《National food safety standard:Beverage》And GB/T4789.24-2003《Food
Sanitary microorganism is examined》It is sampled inspection;
(6) be put in storage:Qualified product will be examined to be housed in relative humidity≤30%, oxygen concentration≤5%, 4 DEG C of temperature
Under the conditions of.
The Chinese medicine composition of lung is supported in a kind of clearing lung-heat of embodiment 4
Including component:7 parts of radix glehniae, 10 parts of Loquat-Shaped Cake, 30 parts of Chinese yam, 15 parts of reed rhizome, 9 parts of korean pine seed, 14 parts of Poria cocos, Soviet Union
8 parts of leaf, 12 parts of dark plum, 8 parts of emblic, 6 parts of plantain seed, 9 parts of Chloranthus glaber, 6 parts of great burdock achene, 11 parts of root of Chinese trichosanthes, 10 parts of blackberry lily, hundred
5 parts of portion, 2.5 parts of aster.
Preparation method:
(1) check and accept:Under the conditions of 100,000 grades of clean areas, raw material is carried out by beverage processing raw material acceptance criteria;
(2) pre-process:By radix glehniae, Loquat-Shaped Cake, Chinese yam, reed rhizome, korean pine seed, Poria cocos, perilla leaf, dark plum, emblic, Chinese herbaceous peony
Son, Chloranthus glaber, great burdock achene, root of Chinese trichosanthes, blackberry lily, the tuber of stemona, aster carry out ultramicro grinding and cross 2000 mesh sieves, standby;
(3) extract:By pretreated radix glehniae, Loquat-Shaped Cake, Chinese yam, reed rhizome, korean pine seed, Poria cocos, perilla leaf, dark plum, remaining
Gan Zi, plantain seed, great burdock achene, root of Chinese trichosanthes, blackberry lily, the tuber of stemona, aster, which add water, carries out decoction extraction, decocts extraction 2.2h, decocts leaching
After carrying, Chloranthus glaber is added and carries out boiling extraction 20min, repeats to decoct leaching process 2 times, after terminating, is carried out after centrifugal filtration
Cryogenic vacuum is concentrated, and produces drink concentrate, is stored standby into medicine storing pot;
(4) pack:Drink concentrate is diluted and aseptic packaging;
(5) examine:According to GB7101-2015《National food safety standard:Beverage》And GB/T4789.24-2003《Food
Sanitary microorganism is examined》It is sampled inspection;
(6) be put in storage:Qualified product will be examined to be housed in relative humidity≤30%, oxygen concentration≤5%, 4 DEG C of temperature
Under the conditions of.
The Chinese medicine composition of lung is supported in a kind of clearing lung-heat of embodiment 5
Include according to the raw material of parts by weight:8.5 parts of radix glehniae, 8.5 parts of Loquat-Shaped Cake, 22.5 parts of Chinese yam, 22.5 parts of reed rhizome, sea
7.5 parts of pine nut, 12.5 parts of Poria cocos, 7 parts of perilla leaf, 9 parts of dark plum, 6 parts of emblic, 7.5 parts of plantain seed, 12 parts of Chloranthus glaber, great burdock achene
7.5 parts, 12.5 parts of root of Chinese trichosanthes, 6.5 parts of blackberry lily, 6 parts of the tuber of stemona, 8.7 parts of aster.
Preparation is concretely comprised the following steps:
(1) check and accept:Under the conditions of 100,000 grades of clean areas, raw material is carried out by beverage processing raw material acceptance criteria;
(2) pre-process:By radix glehniae, Loquat-Shaped Cake, Chinese yam, reed rhizome, korean pine seed, Poria cocos, perilla leaf, dark plum, emblic, Chinese herbaceous peony
Son, Chloranthus glaber, great burdock achene, root of Chinese trichosanthes, blackberry lily, the tuber of stemona, aster carry out ultramicro grinding and cross 2000 mesh sieves, standby;
(3) extract:By pretreated radix glehniae, Loquat-Shaped Cake, Chinese yam, reed rhizome, korean pine seed, Poria cocos, perilla leaf, dark plum, remaining
Gan Zi, plantain seed, great burdock achene, root of Chinese trichosanthes, blackberry lily, the tuber of stemona, aster, which add water, carries out decoction extraction, decocts extraction 2.2h, decocts leaching
After carrying, Chloranthus glaber is added and carries out boiling extraction 20min, repeats to decoct leaching process 2 times, after terminating, is carried out after centrifugal filtration
Cryogenic vacuum is concentrated, and produces drink concentrate, is stored standby into medicine storing pot;
(4) pack:Drink concentrate is diluted and aseptic packaging;
(5) examine:According to GB7101-2015《National food safety standard:Beverage》And GB/T4789.24-2003《Food
Sanitary microorganism is examined》It is sampled inspection;
(6) be put in storage:Qualified product will be examined to be housed in relative humidity≤30%, oxygen concentration≤5%, 4 DEG C of temperature
Under the conditions of.
Zoopery
Research to atomized liquid resolve phlegm effect of the present invention
1st, it is grouped and is administered:
18-22g Kunming mouses, male and female half and half are randomly divided into blank control group, positive control by body weight, sex equilibrium
Group, administration group (point high dose group, middle dose group and low dose group), every group 10.Wherein blank control group gives distilled water
10ml/kg, positive controls give hydrochloric acid helium bromine rope 100mg/kg, and medicine used by administration group is atomized liquid of the present invention, simply dense
Degree is different, and high dose group gives 16ml/kg, and middle dose group gives 8ml/kg, and low dose group gives 4ml/kg.
2nd, method:
(1) preparation of phenol red solution:
(1) NaOH preparation, precision is weighed after NaOH crystalline solid 2g, a small amount of distilled water diluting, is settled to 50ml, is made into
1mol/L NaOH solution is standby.
(2) preparation of 7.05mmol/L (0.25g/dl) phenol red solution, precision weighs phenol red powder 0.5g, with what is prepared
NaOH solution 5ml dissolves, plus normal saline dilution is to 200ml, shakes up standby.
(2)2.24mmol/L(5g/dl)NaHCO3The preparation of solution:
Precision weighs NaHCO3Crystalline solid 5g, distills water dissolves with 50ml, is diluted to 100ml, shakes up standby.
(3) preparation of visual inspection standard pipe:
Assay balance precision weighs phenol red 0.1mg, with 100mlNaHCO3Solution (5g/dl) dilutes, and is configured to 1000 μ
G/ml phenol red solution, is used as a pipe solution;Solution 0.1ml in a pipe is taken, 100ml is diluted to, is used as 1ng/ml standards
Pipe;Solution 0.1ml in a pipe is taken, 50ml is diluted to, is used as 2ng/ml standard pipes;Solution 0.3ml in a pipe is taken, is diluted to
100ml, is used as 3ng/ml standard pipes;Solution 0.2ml in a pipe is taken, 50ml is diluted to, is used as 4ng/ml standard pipes;Take No. one
Solution 0.25ml, is diluted to 50ml, is used as 5ng/ml standard pipes in pipe;Solution 0.3ml in a pipe is taken, 50ml is diluted to, made
For 6ng/ml standard pipes;Solution 0.35ml in a pipe is taken, 50ml, as 7ng/ml standard pipes is diluted to;Take molten in a pipe
Liquid 0.4ml, is diluted to 50ml, as 8ng/ml standard pipes;Solution 0.45ml in a pipe is taken, 50ml, as 9ng/ is diluted to
Ml standard pipes;Solution 0.5ml in a pipe is taken, 50ml, as 10ng/ml standard pipes is diluted to;Take solution in a pipe
0.75ml, is diluted to 50ml, as 15ng/ml standard pipes;Solution 1ml in a pipe is taken, 50ml, as 20ng/ml is diluted to
Standard pipe.The standard pipe numbering sealing preserve prepared is standby (3ml/ pipes).
(4) experimentation:
Each group presses the continuous spray delivery 4d of above-mentioned dosage, and each group spray velocity is fixed, and is remained a constant speed, and administration time is
30min.Injected through abdominal cavity and neck execution mouse is taken off after 7.05mmol/L (0.25g/dl) phenol red solution 0.5ml, injection 30min, faced upward
Position is fixed on surgical plate, cuts off positive skin in neck, separates hypodermis, exposure tracheae, in No. 7 that polish head under larynx
Syringe needle inserts tracheal strips about 0.3cm, is ligatured and fixed with silk thread, and 2.24mmol/L (5g/dl) NaHCO is drawn with 1ml syringes3It is molten
Liquid 0.5ml, respiratory tract is rinsed by syringe needle 4 times back and forth.Cleaning solution is collected into test tube, NaHCO is drawn again3Solution
0.5ml, is washed one's hands and face 4 times again as described above, is collected cleaning solution, is so repeated 4 times altogether, is collected 4 cleaning solutions and is mixed, 3000r/min from
Heart 10min, takes supernatant with carrying out colorimetric under the made visual inspection standard pipe natural light of step (3), as a result such as following table.
To mouse expectorant test influence (N=10)
Note:Compared with control group:“*”P<0.05.
3rd, conclusion:
It can be seen that from above-mentioned experimental result phenol red during three dosage groups of atomized liquid of the present invention increase flushing liquor in various degree
Content, and dose-effect dependence is presented, act on the most obvious with high dose group, being compared with blank control group has significant difference (P
< 0.05), point out atomized liquid of the present invention to reduce the generation of sputum under higher dosage.
Clinical test
To the Experiment on therapy of division of respiratory disease clinical symptoms
- 2016 years on the 16th November in 2016 on December 15, (period includes heavy air pollution process several times) division of respiratory disease is selected to see a doctor
The people of patient 60.It is wherein male 30, female 30;The pharyngeal discomfort of clinical symptoms, mycteroxerosis, coughing with a lot of sputum, respiratory inflammation etc..Will
Man, female patient are equally divided into three groups of administration group, blank control group and positive controls, every group of 10 people, administration group mist of the present invention
Change liquid, the positive controls solution of acetylcystein (NAC) atomized liquid 10%, blank control group is with physiological saline (NS).Above-mentioned 3 kinds of systems
Agent is respectively placed in ultrasonic atomizer, is atomized 1~3ml every time, and record before and after nebulae inhalation 15, the clinical disease of 30 minutes
End of love.Judge content as short term effect by the curative effect in after nebulae inhalation 60 minutes.Primary disease is treated by protopathy,
But it ought daily refuse to apply cough-relieving and Apophlegmatisant in atomization.
Evaluation criterion:Recovery from illness:Clinical symptom disappearance.Effectively:Clinical symptoms take a turn for the better.It is invalid:Clinical symptoms are unchanged.
Treatment results:It see the table below.Blank control group is fully recovered 0, effective 0, invalid 20;Positive controls are fully recovered 7,
Effective 8, invalid 5, total effective rate is 75%.Administration group is fully recovered 9, and effective 10, invalid 1, total effective rate is 95%.
Group | It is invalid | Effectively | Recovery from illness |
Male administration group | 1 | 5 | 4 |
Male positive controls | 3 | 4 | 3 |
Male blank control group | 10 | 0 | 0 |
Female's administration group | 0 | 5 | 5 |
Female's positive controls | 2 | 4 | 4 |
Female's blank control group | 10 | 0 | 0 |
Embodiment described above only expresses the several embodiments of the present invention, and it describes more specific and detailed, but simultaneously
Therefore the limitation to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that for one of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect scope.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (8)
1. the Chinese medicine composition of lung is supported in a kind of clearing lung-heat, it is characterised in that including component:5-12 parts of radix glehniae, Loquat-Shaped Cake 5-12 parts,
15-30 parts of Chinese yam, 15-30 parts of reed rhizome, 5-10 parts of korean pine seed, 10-15 parts of Poria cocos, 5-9 parts of perilla leaf, 6-12 parts of dark plum, emblic
3-9 parts, 5-10 parts of plantain seed, 9-15 parts of Chloranthus glaber, 5-10 parts of great burdock achene, 10-15 parts of root of Chinese trichosanthes, 3-10 parts of blackberry lily, tuber of stemona 3-9
Part, 2.5-15 parts of aster.
2. composition according to claim 1, it is characterised in that the composition includes:7-10 parts of radix glehniae, Loquat-Shaped Cake
7-10 parts, 19-26 parts of Chinese yam, 19-26 parts of reed rhizome, 6-9 parts of korean pine seed, 11-14 parts of Poria cocos, 6-8 parts of perilla leaf, 8-11 parts of dark plum,
5-8 parts of emblic, 6-9 parts of plantain seed, 11-14 parts of Chloranthus glaber, 6-9 parts of great burdock achene, 11-14 parts of root of Chinese trichosanthes, 5-8 parts of blackberry lily, hundred
Portion 5-8 parts, 6-12 parts of aster.
3. composition according to claim 2, it is characterised in that the composition includes:8.5 parts of radix glehniae, Loquat-Shaped Cake
8.5 parts, 22.5 parts of Chinese yam, 22.5 parts of reed rhizome, 7.5 parts of korean pine seed, 12.5 parts of Poria cocos, 7 parts of perilla leaf, 9 parts of dark plum, 6 parts of emblic,
7.5 parts of plantain seed, 12 parts of Chloranthus glaber, 7.5 parts of great burdock achene, 12.5 parts of root of Chinese trichosanthes, 6.5 parts of blackberry lily, 6 parts of the tuber of stemona, 8.7 parts of aster.
4. the preparation method of the Chinese medicine composition of lung is supported in a kind of clearing lung-heat as claimed in claim 1, it is characterised in that including:Tool
Body step is:
(1) check and accept:Under the conditions of 100,000 grades of clean areas, raw material is carried out by beverage processing raw material acceptance criteria;
(2) pre-process:By radix glehniae, Loquat-Shaped Cake, Chinese yam, reed rhizome, korean pine seed, Poria cocos, perilla leaf, dark plum, emblic, plantain seed,
Chloranthus glaber, great burdock achene, root of Chinese trichosanthes, blackberry lily, the tuber of stemona, aster carry out ultramicro grinding and cross 2000 mesh sieves, standby;
(3) extract:According to each component mass fraction in each claim 1 by pretreated radix glehniae, Loquat-Shaped Cake, Chinese yam, reed
Root, korean pine seed, Poria cocos, perilla leaf, dark plum, emblic, plantain seed, great burdock achene, root of Chinese trichosanthes, blackberry lily, the tuber of stemona, aster, which add water, is decocted
Extraction is boiled, extraction 1.8-2.2h is decocted, decocts after extraction, Chloranthus glaber is added and carries out boiling extraction 10-20min, repeats to decoct
Leaching process 2 times, after terminating, carries out cryogenic vacuum concentration, produces drink concentrate, store standby into medicine storing pot after centrifugal filtration
With;
(4) pack:Drink concentrate is diluted and aseptic packaging;
(5) examine:According to GB7101-2015《National food safety standard:Beverage》And GB/T4789.24-2003《Food hygiene
Micro biological Tests》It is sampled inspection;
(6) be put in storage:Qualified product will be examined to be housed in relative humidity≤30%, oxygen concentration≤5%, the condition that 4 DEG C of temperature
Under.
5. preparation method according to claim 4, it is characterised in that extraction 2.0h is decocted in the step (3).
6. preparation method according to claim 4, it is characterised in that Chloranthus glaber is added in step (3) and carries out boiling leaching
Carry 15min.
7. the Chinese medicine composition described in a kind of any one of claim 1-3, answering in the preventing and treating and health care of respiratory disease
With.
8. the Chinese medicine composition obtained by a kind of any one of the claim 4-6 preparation method, in the anti-of respiratory disease
Control and the application in health care.
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1850249A (en) * | 2005-07-18 | 2006-10-25 | 鲁南制药集团股份有限公司 | Composition with function of relieving cough and calming asthma and preparing method |
CN101491634A (en) * | 2008-01-23 | 2009-07-29 | 北京亚东生物制药有限公司 | Traditional Chinese medicine composition for treating chronic pharyngitis and preparation method and quality control method thereof |
-
2017
- 2017-03-06 CN CN201710128039.5A patent/CN106943560B/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1850249A (en) * | 2005-07-18 | 2006-10-25 | 鲁南制药集团股份有限公司 | Composition with function of relieving cough and calming asthma and preparing method |
CN101491634A (en) * | 2008-01-23 | 2009-07-29 | 北京亚东生物制药有限公司 | Traditional Chinese medicine composition for treating chronic pharyngitis and preparation method and quality control method thereof |
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Title |
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小张仙: "家传秘方治顽固咳嗽", 《小张仙的博客》 * |
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