CN106823079A - A kind of quantitative atomized medicine introducing device of delivery type - Google Patents
A kind of quantitative atomized medicine introducing device of delivery type Download PDFInfo
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- CN106823079A CN106823079A CN201710193382.8A CN201710193382A CN106823079A CN 106823079 A CN106823079 A CN 106823079A CN 201710193382 A CN201710193382 A CN 201710193382A CN 106823079 A CN106823079 A CN 106823079A
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- delivery type
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- upper lid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
- A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
- A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
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- Anesthesiology (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
A kind of quantitative atomized medicine introducing device of delivery type, including crust of the device, doser (1), atomising device (2) and upper lid (3), it is characterized in that, doser (1) and atomising device (2) are arranged in crust of the device, and upper lid (3) is arranged on crust of the device.The present apparatus is easy to operate, small and exquisite to be easy to carry, and employing electromagnetic viscosimeter principle makes medical liquid atomizing, and droplet is small, and easily into respiratory tract, distinctive metering pump device can realize the dosed administration of medicine.The present apparatus can actively be administered, and can passively be administered again, and different administering modes is applicable to different patients.
Description
Technical field
The present invention relates to medical instruments field, more particularly to a kind of quantitative atomized medicine introducing device of delivery type.
Background technology
In the prior art, asthma and the existing therapeutic modality of chronic obstructive pulmonary disease mainly have orally/injection and suction etc., but it is oral and
Medicine all first can be sent to blood again to lung by injection, so often less efficient.Fog inhalation therapy, is treatment breathing at present
One of conventional method of systemic disease.Its method makes medicine directly act on lesions position without each organ of human body, reduces
Medicine alleviates toxic and side effect in the decomposition of the organ such as stomach and intestine and liver, kidney.Fog inhalation therapy belongs to non-invasive treatment hand
Section, short treating period, survival dose are few, instant effect, alleviate patient and have an injection the painful and inconvenience taken medicine, especially in influenza, respiratory tract
Disease prone period, the prevention effect of the therapy is that traditional remedies can not compare.
Nebulizer administration device major way has ultrasonic atomizatio and jetting type to be atomized two kinds, and ultrasonic atomizatio is mainly using super
Sound principle converts electrical energy into the sound wave of superelevation audio by converter, and (general conventional converter material is piezoceramics crystal
Piece), ultrasonic wave causes drug solution to vibrate and produce aerosol particles;And jetting type atomization it is main using jet current principle by medicine or
Water disperses to be suspended in gas through suction apparatus by mutually clashing into droplet or particulate, and breathing is deposited on by way of suction
Road and (or) lung, so as to reach the effect of respiratory tract local treatment.But ultrasonic atomizatio needs transducer directly to be shaken to liquid
Atomization is swung, structure is relative complex, while the surface tension in order to destroy liquid, its supersonic frequency inactivates some drugses can not be complete
Portion's medicine is all suitable for.And jet atomization particle is big, the drug particles major part of suction is deposited on the upper respiratory tracts such as oral cavity and throat;
Air compression type atomizing particle is big, proportion of the atomizing particle below 5 microns only 60% or so, and effective rate of utilization is low.Compare into
The jet atomization of work(is the soft mist agent that Boehringer Ingelheim company releases, but the doser is complicated, causes drug price to hold high
It is expensive, although to use and more facilitate, but also increase the drug cost of patient.Though simultaneously ultrasonic atomizatio or jet atomization,
Temperature is less than oral cavity, the temperature of trachea and bronchus after the atomization of its liquid, often cause patient take place frequently cough, breathe, or cough original
Cough, breathe and aggravate and refuse Neulized inhalation.
Also there is the new nebulization equipment of multiple Patent designs at present.
China Patent Publication No. CN103432660A, publication date:On December 11st, 2013, entitled portable medical
Atomizer, this application case discloses a kind of medicine absorber, there is provided one kind has sealing function, excessive low water level protection function and can be atomized out
The Portable medical atomizer of the droplet of more small-bore.But this application is by high-frequency resonant, atomizing piece and liquid is directly allowed to contact,
Liquid touches atomizing piece, just can produce atomization.Its principle is also the use of the principle of ultrasonic atomizatio, and the drug particles of suction are big
The upper respiratory tracts such as oral cavity and throat are partially depositing in, the drawbacks of have certain.
China Patent Publication No. CN103582505A, publication date:On 02 12nd, 2014, entitled sprayer should
Application case discloses a kind of medicine absorber, and it includes can be inserted into storage tank of the rigid container as to be atomized or spraying fluid, passes through
Driving spring pressure generator causes that storage tank Chinese medicine liquid is spouting.The invention is filled as the soft mist agent that Boehringer Ingelheim is invented
The patent put, the droplet temperature that it is formed, less than oral cavity, the temperature of trachea and bronchus, easily causes patient close to room temperature
Sense of discomfort.
China Patent Publication No. CN102247640B, publication date:On 09 18th, 2013, entitled atomising device,
This application case discloses a kind of inhalator, heater is utilized to produce water vapour, device it include that angular transducer and speed are passed
Sensor come control atomization amount and fogging degree.Heating of this application by liquid repeatedly, hot poor liquid is received for those
Easily inactivate it, so that the selection face of liquid is narrower, and this device volume is not larger portable, for patients compared with
It is inconvenience.
China Patent Publication No. CN102160906A, publication date:On November 01st, 2010, entitled mouth suction is portable
Atomizer, this application case discloses a kind of inhalator, and this device produces the liquid that negative pressure will be stored equal by guide wire by air-breathing
It is directed to be heated on heater evenly and produces droplet.The guide wire long-time heating of this device is atomized easy blocking pipeline to be caused
Atomization quantity deficiency is so as to be unable to reach therapeutic effect.
The content of the invention
To overcome the drawbacks described above of prior art, the present invention to provide a kind of delivery type quantitative atomized medicine introducing device, Yi Zhongdi
Send formula quantitative atomized medicine introducing device, including crust of the device, doser, atomising device and upper lid, it is characterised in that doser
It is arranged in crust of the device with atomising device, upper lid is arranged on crust of the device.
Further, medicine bottle is set in the doser, and medicine bottle lower end sets magnetic valve, wherein, medicine bottle top sets meter
Amount pump, measuring pump one end sets woven hose;Medicine bottle bottom sets administration push pedal.
Further, the atomising device includes electronic atomizer, air pump and battery pack, wherein, air pump is connected to electronic fog
Change device lower end, battery pack is located at air pump lower end.
Further, the electronic atomizer upper end sets storage liquid medicine box, and liquid medicine box is stored up in the woven hose connection of measuring pump one end,
Passive administration triggering device is set in electronic atomizer.
Further, upper lid suction nozzle is set in the upper lid, hollow spray chamber is set in upper lid suction nozzle, spray chamber side sets
Put guiding gutter, upper lid suction nozzle external connection oronasal mask.
Further, the electronic atomizer is located at spray chamber bottom.
Further, actively administration switch, metering display screen are set on the doser;Administration valve is set on atomising device
Switch, electronics concussion chip and display lamp and external power supply socket.
Further, the atomization uses electronic mode of heating, i.e., closed using LC (inductor-capacitor) oscillating circuit
And the atomizing type for heating.
Alternatively, battery pack is solar energy charging battery, and solar panel is arranged at crust of the device surface, and with electricity
Pond group is connected.
Device of the present invention can be used the aqueous solution of beta-receptor activator or M3 receptor blocking pharmacons;Preferred beta-receptor swashs
Dynamic agent is salbutamol, levosalbutamol, Terbutaline, salmeterol, clenbuterol, fenoterol, Formoterol, Ao Date
One or more in sieve, QAB-149, dimension Lactel sieve;Preferred M3 receptor blocking pharmacons are glycopyrronium bromide, Tiotropium Bromide, isopropyl
Support bromine ammonium, aclidinium bromide, one or more in Wumei bromine ammonium.
Device of the present invention can be used the mixing of one or more of beta-receptor activator and M3 receptor blocking pharmacons water-soluble
Liquid;Preferred beta-receptor activator is salbutamol, levosalbutamol, Terbutaline, salmeterol, clenbuterol, Fei Nuote
One or more in sieve, Formoterol, Ao Dateluo, QAB-149, dimension Lactel sieve;Preferred M3 receptor blocking pharmacons are that lattice are grand
Bromine ammonium, Tiotropium Bromide, Ipratropium Bromide, aclidinium bromide, one or more in Wumei bromine ammonium.
Present invention combination quantitative chemical adding device, employing electromagnetic viscosimeter principle makes quantitative medical liquid atomizing, and droplet is small, easily suction
Respiratory tract.The present apparatus does not use propellant, directly use medical liquid atomizing, it is to avoid the common freon of inhalation aerosol is substituted
Problem.Electromagnetic pump and metering pump device can realize the dosed administration of medicine, need to enter at any time, for a long time particularly with asthma patient etc.
Row respiratory administration situation provides facility.
Compared to the prior art, the present apparatus is easy to operate, small and exquisite to be easy to carry, and employs electromagnetic viscosimeter principle for the present invention
Make medical liquid atomizing, droplet is small, easily into respiratory tract, distinctive metering pump device can realize the dosed administration of medicine.The present apparatus was both
Can actively be administered, can passively be administered again, different administering modes is applicable to different patients.
Brief description of the drawings
Fig. 1 is the quantitative atomized medicine introducing device structure chart of delivery type.
Fig. 2 is Salbutamol respirator solution delivery performance evaluation figure.
Specific embodiment
As shown in figure 1, a kind of quantitative atomized medicine introducing device of delivery type, including crust of the device, doser 1, atomising device 2
With upper lid 3, doser 1 and atomising device 2 are arranged in crust of the device, and upper lid 3 is arranged on crust of the device.
Medicine bottle 11 is set in the doser 1, and the lower end of medicine bottle 11 sets magnetic valve 15, wherein, the top of medicine bottle 11 is set
Measuring pump 12, one end of measuring pump 12 sets woven hose 13;The bottom of medicine bottle 11 sets administration push pedal 14.
The atomising device 2 includes electronic atomizer 21, air pump 22 and battery pack 23, wherein, air pump 22 is connected to electronics
The lower end of atomizer 21, battery pack 23 is located at the lower end of air pump 22.
The upper end of the electronic atomizer 21 sets storage liquid medicine box 211, the connection drug storage liquid of woven hose 13 of the one end of measuring pump 12
Box 211, sets passive administration triggering device 212 in electronic atomizer 21.
Upper lid suction nozzle 31 is set in the upper lid 3, hollow spray chamber 32, the side of spray chamber 32 are set in upper lid suction nozzle 31
Guiding gutter 33, the external connection oronasal mask 34 of upper lid suction nozzle 31 are set.
The electronic atomizer 21 is located at the bottom of spray chamber 32.
Actively administration switch 16, metering display screen 17 are set on the doser 1;Administration valve is set on atomising device 2
Switch 24, electronics concussion chip and display lamp 25 and external power supply socket 26.Metering display screen 17 can show that insecticide left is used
Amount.
Battery pack 23 is solar energy charging battery, and solar panel is arranged at crust of the device surface, and and battery pack
23 are connected.
The present apparatus can be used the aqueous solution of beta-receptor activator or M3 receptor blocking pharmacons;Preferred beta-receptor activator is sand
Butylamine alcohol, levosalbutamol, Terbutaline, salmeterol, clenbuterol, fenoterol, Formoterol, Ao Dateluo, indenes reach
One or more in special sieve, dimension Lactel sieve;Preferred M3 receptor blocking pharmacons are glycopyrronium bromide, Tiotropium Bromide, Ipratropium Bromide,
Aclidinium bromide, one or more in Wumei bromine ammonium.
The present apparatus can be used the mixed aqueous solution of one or more of beta-receptor activator and M3 receptor blocking pharmacons;Preferably
Beta-receptor activator is salbutamol, levosalbutamol, Terbutaline, salmeterol, clenbuterol, fenoterol, Fu Mote
One or more in sieve, Ao Dateluo, QAB-149, dimension Lactel sieve;Preferred M3 receptor blocking pharmacons are glycopyrronium bromide, thiophene support
Bromine ammonium, Ipratropium Bromide, aclidinium bromide, one or more in Wumei bromine ammonium.
Embodiment 1
During use, user's dosage as requested presses administration threshold switch button 24 for fixed time, magnetic valve 15 and pushes away
Plate 14 promotes medicine bottle 11, medicine that the liquid medicine storage device 211 of the upper end of spray chamber 21 is sent into by measuring pump 12 and conduit 13, and dosage is then
Can be shown on metering display screen 17.After liquid input is finished, user contains suction nozzle 31 and aspirates with mouth, and the passive administration of triggering is touched
Transmitting apparatus 212, make circuit turn-on, and display lamp is bright, and electronic atomizer 21 and air pump 22 are started working, medical liquid atomizing, and patient is by medicine
Thing sucks respiratory tract.The generation medicine mist only when patient aspirates passively is administered, the waste of medicine is reduced.
Embodiment 2
During use, user's dosage as requested presses administration threshold switch button 24 for fixed time, magnetic valve 15 and pushes away
Plate 14 promotes medicine bottle 11, medicine that the liquid medicine storage device 211 of the upper end of spray chamber 21 is sent into by measuring pump 12 and conduit 13, and dosage is then
Can be shown on metering display screen 17.User contains suction nozzle 31 with mouth, pins actively administration switch 16, the He of electronic atomizer 21
Air pump 22 will continuous firing, medicine sucks respiratory tract by medical liquid atomizing, patient.Under active administering mode, medicine can be continuous
Sprayed from suction nozzle, until the liquid in liquid storage box, all atomization is finished, and patient may be inhaled quantitative medicine.
Active administering mode and passive administering mode are applicable to different patients.
Embodiment 3
During use, user can take out medicine bottle 11 to change medicine bottle by opening upper lid suction nozzle 31.
Embodiment 4
By taking salbutamol sulfate inhalation solution as an example, during its liquid poured into atomising device of the invention, traditional Chinese medicines in use
2015 editions evaluating apparatus included of allusion quotation, test evaluation pharmaceutical properties analysis, it can be seen that the drug delivery capabilities of the present apparatus.
Concrete operation step is as follows:
The ram that will be assembled and L-type connecting tube precooling at least 90 minutes in refrigerator (5 DEG C), after being taken out from refrigerator
Start to determine in 5 minutes.
Ram is taken out from refrigerator, L-type connecting tube is connected, and the outlet of ram is connected with vavuum pump.Open true
Empty pump, flowmeter is connected with L-type connecting tube, regulation flow control valve make the gas flow rate of L-type connecting tube import for (15 ±
0.75) L/min, removes flowmeter.
Test sample 1 is taken, content is fully transferred in atomising device.Suction nozzle is connected into L-type by adapter to connect
Adapter.Compressor is opened, nebulisation time is set as 10min.Close compressor, atomising device is removed from L-type connecting tube, is closed
Close vavuum pump.Remove ram, with leacheate be respectively washed sprayer, L-type connecting tube, each level (S1, S2, S3, S4, S5,
S6, S7) and additional filter paper (MOC), cleaning volume be respectively 100ml, 5ml, 10ml, 10ml, 20ml, 20ml, 20ml, 10ml,
10ml、10ml。
Taking liquid, content detection is carried out with high performance liquid chromatography.
Sample 1, the experimental result of sample 2 are shown in accompanying drawing 2.
Embodiment 5
By taking budesonide inhalation solution as an example, according to 2015 editions related requests of Chinese Pharmacopoeia, the delivery rate of determination sample
With delivering total amount.
Concrete operation step is as follows.
1, sample is taken, the respiration simulator of selection adult mode is connected, the working time of respiration simulator is set as
1min, starts atomizer while breath cycle starts, and atomizer is closed while breath cycle terminates.By filter paper from filter paper
Taken out in device, cleaned with leacheate, merged washing lotion and be settled to 25ml, obtain final product need testing solution 1.Test sample in unit interval
Medication amount in solution 1 is delivery rate.
1, sample is taken, connection determines device, and the working time for setting respiration simulator is set as 9min, in breath cycle
Start atomizer while beginning, atomizer is closed while breath cycle terminates.Filter paper is taken out from filter paper device, with pouring
Washing lotion is cleaned, and is merged washing lotion and is settled to 50ml, obtains final product need testing solution 2.Medicine total amount in need testing solution 2 is delivering
Total amount.
Determination data sees the above table, and self-control is basically identical with delivery rate and delivering total amount that original grinds product.
Present invention combination quantitative chemical adding device, employing electromagnetic viscosimeter principle makes quantitative medical liquid atomizing, and droplet is small, easily suction
Respiratory tract.The present apparatus does not use propellant, directly using medical liquid atomizing, the step of eliminate replacement medicament, and electromagnetic pump and quantitative
Pump installation can realize the dosed administration of medicine, and carrying out respiratory administration situation at any time, for a long time particularly with the needs such as asthma patient carries
For facility.And present apparatus device is compact, it is easy to operate and carries, is applicable to different medicines.
Finally it should be noted that above example is only used to describe technical scheme rather than to this technology method
Limited, the present invention application can above extend to other modifications, change, using and embodiment, and it is taken as that institute
Have such modification, change, using, embodiment all in the range of spirit or teaching of the invention.
Claims (10)
1. a kind of delivery type quantifies atomized medicine introducing device, including crust of the device, doser (1), atomising device (2) and upper lid
(3), it is characterised in that doser (1) and atomising device (2) are arranged in crust of the device, upper lid (3) is arranged at crust of the device
On.
2. delivery type according to claim 1 quantifies atomized medicine introducing device, it is characterised in that in the doser (1)
Medicine bottle (11) is set, and medicine bottle (11) lower end sets magnetic valve (15), wherein, medicine bottle (11) top sets measuring pump (12), metering
Pump (12) one end sets woven hose (13);Medicine bottle (11) bottom sets administration push pedal (14).
3. delivery type according to claim 1 quantifies atomized medicine introducing device, it is characterised in that atomising device (2) bag
Electronic atomizer (21), air pump (22) and battery pack (23) are included, wherein, air pump (22) is connected to electronic atomizer (21) lower end,
Battery pack (23) is positioned at air pump (22) lower end.
4. the quantitative atomized medicine introducing device of delivery type according to Claims 2 or 3, it is characterised in that the electronic atomizer
(21) upper end sets storage liquid medicine box (211), the woven hose (13) connection storage liquid medicine box (211) of measuring pump (12) one end, electronic fog
Change the passive administration triggering device (212) of setting in device (21).
5. delivery type according to claim 1 quantifies atomized medicine introducing device, it is characterised in that set in the upper lid (3)
Hollow spray chamber (32) is set in upper lid suction nozzle (31), upper lid suction nozzle (31), and spray chamber (32) side sets guiding gutter (33),
Upper lid suction nozzle (31) external connection oronasal mask (34).
6. the quantitative atomized medicine introducing device of delivery type according to claim 3 or 5, it is characterised in that the electronic atomizer
(21) positioned at spray chamber (32) bottom.
7. delivery type according to claim 1 quantifies atomized medicine introducing device, it is characterised in that on the doser (1)
Actively administration switch (16), metering display screen (17) are set;Administration threshold switch (24), electronics concussion are set on atomising device (2)
Chip and display lamp (25) and external power supply socket (26).
8. the quantitative atomized medicine introducing device of delivery type according to claim 1 or 3, it is characterised in that the battery pack (23)
It is solar energy charging battery, solar panel is arranged at crust of the device surface, and is connected with battery pack (23).
9. the quantitative atomized medicine introducing device of delivery type according to any one of claim 1 to 8, it is characterised in that the present apparatus can
Use beta-receptor activator or the aqueous solution of M3 receptor blocking pharmacons;Preferred beta-receptor activator is salbutamol, left husky butylamine
In alcohol, Terbutaline, salmeterol, clenbuterol, fenoterol, Formoterol, Ao Dateluo, QAB-149, dimension Lactel sieve
One or more;Preferred M3 receptor blocking pharmacons are glycopyrronium bromide, Tiotropium Bromide, Ipratropium Bromide, aclidinium bromide, Wumei bromine
One or more in ammonium.
10. the quantitative atomized medicine introducing device of delivery type according to claim 9, it is characterised in that the present apparatus can be used β-receive
The mixed aqueous solution of one or more of body activator and M3 receptor blocking pharmacons;Preferred beta-receptor activator be salbutamol,
Levosalbutamol, Terbutaline, salmeterol, clenbuterol, fenoterol, Formoterol, Ao Dateluo, QAB-149, dimension
One or more in Lactel sieve;Preferred M3 receptor blocking pharmacons are glycopyrronium bromide, Tiotropium Bromide, Ipratropium Bromide, Ah 's bromine
Ammonium, one or more in Wumei bromine ammonium.
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Cited By (5)
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CN107233657A (en) * | 2017-08-09 | 2017-10-10 | 陈红 | A kind of division of respiratory disease chemical sprayer |
CN107376070A (en) * | 2017-07-17 | 2017-11-24 | 太仓秦风广告传媒有限公司 | A kind of portable atomization therapeutic device quantitatively discharged |
CN107569748A (en) * | 2017-08-23 | 2018-01-12 | 苏州浩哥文化传播有限公司 | It is a kind of can instantaneously changing holding bottle atomization therapeutic device |
CN112472979A (en) * | 2020-12-02 | 2021-03-12 | 中国人民解放军陆军军医大学第一附属医院 | Micro-administration equipment for infants |
CN114992080A (en) * | 2022-06-01 | 2022-09-02 | 南京市水利规划设计院股份有限公司 | Water resource metering control device and control method thereof |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN107376070A (en) * | 2017-07-17 | 2017-11-24 | 太仓秦风广告传媒有限公司 | A kind of portable atomization therapeutic device quantitatively discharged |
CN107233657A (en) * | 2017-08-09 | 2017-10-10 | 陈红 | A kind of division of respiratory disease chemical sprayer |
CN107569748A (en) * | 2017-08-23 | 2018-01-12 | 苏州浩哥文化传播有限公司 | It is a kind of can instantaneously changing holding bottle atomization therapeutic device |
CN112472979A (en) * | 2020-12-02 | 2021-03-12 | 中国人民解放军陆军军医大学第一附属医院 | Micro-administration equipment for infants |
CN114992080A (en) * | 2022-06-01 | 2022-09-02 | 南京市水利规划设计院股份有限公司 | Water resource metering control device and control method thereof |
CN114992080B (en) * | 2022-06-01 | 2024-04-26 | 南京市水利规划设计院股份有限公司 | Water resource metering control device and control method thereof |
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