CN106808162A - A kind of microneedle array electrode and preparation method thereof - Google Patents
A kind of microneedle array electrode and preparation method thereof Download PDFInfo
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- CN106808162A CN106808162A CN201710091902.4A CN201710091902A CN106808162A CN 106808162 A CN106808162 A CN 106808162A CN 201710091902 A CN201710091902 A CN 201710091902A CN 106808162 A CN106808162 A CN 106808162A
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- microneedle array
- metallic substrates
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- micropin
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23P—METAL-WORKING NOT OTHERWISE PROVIDED FOR; COMBINED OPERATIONS; UNIVERSAL MACHINE TOOLS
- B23P15/00—Making specific metal objects by operations not covered by a single other subclass or a group in this subclass
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
- A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
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- Biomedical Technology (AREA)
- Mechanical Engineering (AREA)
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Abstract
The invention provides a kind of preparation method of microneedle array electrode, including the microneedle array of barb structure is cut out on the metallic substrate, the root of the microneedle array is connected with the metallic substrates；Upper surface direction bending of the microneedle array from root towards the metallic substrates；Electrode button is connected to the lower surface of the metallic substrates；Medical application is fitted in the periphery of the metallic substrates upper surface.The preparation method low cost, easily making, and the microneedle array electrode produced be pierced into human body after due to the presence of barb structure, and the hardness of micropin is higher, micropin is difficult bending or fractures during skin is pierced into, and micropin is difficult to drop in measurement process, so can both meet the detection of people's electro-physiological signals in static state, signal of the people in motion can also be detected, realize long-term, dynamic monitoring.Present invention also offers a kind of microneedle array electrode made using above-mentioned preparation method.
Description
Technical field
The present invention relates to a kind of microneedle array electrode and preparation method thereof, especially a kind of micropin with double-deck barb structure
Array electrode and preparation method thereof.
Background technology
Common physiologic electric signal, occupies critical role, energy including electrocardio, myoelectricity, brain electricity, electrical impedance etc. in clinical diagnosis
The health status and body levels of direct reaction human body.Electro-physiological signals in clinical assay devices, implanted equipment, portable set
Have in standby and widely apply.
The emerging electro-physiological signals metering system of the current comparing for using is using microneedle array electrode measurement.
Microneedle array electrode has the advantage of the following aspects：（ 1）Microneedle array electrode is close to skin table in use
Face, microneedle array electrode surface microneedle epiderm skin cuticula is simultaneously contacted with living Epidermis' layer, thus microneedle array electrode
Use avoid the biologic resistance antinoise signal that increases because cuticula exists；（ 2）Although the use of microneedle array electrode is logical
Cross and be pierced into what skin was realized, but microneedle array size is small, will not cause the pain sensation；（ 3）Be pierced into skin micropin cause electrode-
Skin interface is more stable, therefore can reduce the motion artifact that motion is caused；（ 4）Led without skin treatment and administration using preceding
Electric glue, it is to avoid the allergic or possibility damaged etc..
At present, chemical wet etching comparative maturity in microneedle array manufacturing technology, has widely in microneedle array manufacture field
Using, made microneedle array has length small controllable, and needle point is sharp, the advantages of array pattern is homogeneous, but chemical wet etching master
Will be with crystalline silicon as rapidoprint, the fragility of silicon materials can cause microneedle array easy brittle failure in puncture process, be made in Remained mass
Into harm；And lithographic technique complex process, processing environment is high, high cost.
The content of the invention
It is an object of the invention to provide a kind of low cost, the microneedle electrodes array making method for easily making, and micro- electricity
Pole array is difficult to drop, and micropin intensity is high, is easy to the monitoring of electro-physiological signals, especially in motion process electro-physiological signals prison
Survey.
To achieve the above object, the technical scheme taken of the present invention is：A kind of preparation method of microneedle array electrode, bag
Include：The microneedle array of barb structure is cut out on the metallic substrate, and the root of the microneedle array is connected with the metallic substrates；
Upper surface direction bending of the microneedle array from root towards the metallic substrates；Electrode button is connected to the metallic substrates
Lower surface；Medical application is fitted in the periphery of the metallic substrates upper surface.
The barb structure of microneedle array ensure that micropin after skin is pierced into, is difficult to drop in measurement process, excellent
Choosing, in order that obtaining microneedle array and skin more secure fit, microneedle array can be double-deck barb structure.
Microneedle array directly cuts and obtains on the metallic substrate, and the root of microneedle array is connected with metallic substrates, this
Processing method low cost, easily making.Preferably, laser processing can be selected to cut the micropin with double-deck barb structure
Array, Laser Processing can accurately control the spacing between the height and adjacent micropin of single micropin, and laser machine
Efficiency it is also high, specifically, the height of the micropin of the microneedle array is 300-700 μm, the spacing between each micropin is
0.5-1 mm。
The rapidoprint of micropin is metal, it is ensured that the hardness of micropin so that micropin is not easily broken after skin is pierced into
Split, it is preferred that during the selection of micropin, the characteristics of take into full account electro-physiological signals, can select with biocompatibility
Medical stainless steel as microneedle array rapidoprint.
Preferably, in order to microneedle array electrode is connected with external data record and monitoring device, using welding method
Electrode button is connected to the lower surface of the metallic substrates.
The present invention also provides the microneedle array electrode that a kind of preparation method using above-mentioned microneedle array electrode makes, bag
Include：Microneedle array with barb structure, the microneedle array is formed by metallic substrates cutting, the microneedle array and institute
Intersect in the root of the microneedle array upper surface for stating metallic substrates；Electrode button connects with the lower surface of the metallic substrates
Connect, medical application is fitted in the periphery of the metallic substrates upper surface.
In this microneedle array electrode, microneedle array intersects with the upper surface of metallic substrates in the root of microneedle array,
So that there is certain angle between microneedle array and the upper surface of metallic substrates, so as to form antarafacial microneedle array.
Preferably, the micropin of the microneedle array is double-deck barb structure.
Preferably, the material of the metallic substrates is the medical stainless steel with biocompatibility.Preferably, it is described micro-
The height of the micropin of pin array is 300-700 μm, and the spacing between each micropin needle point is 0.5-1 mm.
Preparation method low cost, the easily making, and the microneedle array electrode produced that the present invention is provided are after human body is pierced into
Because the presence of barb structure, and the hardness of micropin are higher, micropin is difficult bending or fractures during skin is pierced into, and
Micropin is difficult to drop in measurement process, so can both meet the detection of people's electro-physiological signals in static state, can also detect people
Signal in motion, realizes long-term, dynamic monitoring.
Brief description of the drawings
Fig. 1 is the structural representation of the microneedle array electrode of making in the embodiment of the present invention；
Fig. 2 is the micropin schematic diagram of double-deck barb structure in the microneedle array electrode made in the embodiment of the present invention；
Fig. 3 is the forming process schematic diagram of antarafacial microneedle array in the embodiment of the present invention.
Specific embodiment
The following is a kind of embodiment of microneedle array electrode of the present invention, referring to Fig. 1, microneedle array electrode in the present embodiment
Including：Microneedle array 1 with double-deck barb structure, the microneedle array 1 is by the metallic substrates 2 of 50 stainless steel materials
Cutting is formed, and microneedle array 1 intersects with the upper surface of metallic substrates 2 in the root of microneedle array 1, and microneedle array 1
It is mutually perpendicular to metallic substrates 2, forms antarafacial microneedle array；Electrode button 3 is by welding and the following table of metallic substrates 2
Face connects, and medical application 4 is fitted in the periphery of the upper surface of metallic substrates 2.
Referring to Fig. 3, Fig. 3 is the forming process of the antarafacial microneedle array with double-deck barb structure in the embodiment of the present invention
Schematic diagram.Specifically preparation method is：Step a：First pass through laser and the double-deck barb structure of band is processed in metallic substrates 2
Microneedle array 1, the needle point of microneedle array 1 that obtains of processing and the distance of metallic substrates 2 are 700 μm, each micropin pin
Spacing between point is 1 mm；Step b：The microneedle array 1 for obtaining will be processed again from 90 degree of its root bending, makes micropin
Array 1 is mutually perpendicular to metallic substrates 2, forms antarafacial microneedle array.It will be clear that micropin battle array in Fig. 2
The double-deck barb structure of row 1, then electrode button 3 is welded to the lower surface of metallic substrates 2, finally again by medical application
3 peripheries for being fitted in the upper surface of metallic substrates 2.Form the microneedle array electricity of the band bilayer barb structure as shown in Fig. 1
Pole.
The microneedle array electrode obtained by the method because the presence of double-deck barb structure cause microneedle array electrode with
Skin is brought into close contact, and is difficult to drop, and is easy to the monitoring of electro-physiological signals in motion process.The material selection of medical stainless steel plate is filled
Divide the hardness and biocompatibility for considering microneedle array.It is controllable and cost is relatively low, it is easy to push away using Laser Processing cutting technique
Extensively.
Claims (10)
1. a kind of preparation method of microneedle array electrode, it is characterised in that including
The microneedle array of barb structure, the root of the microneedle array and the metallic substrates phase are cut out on the metallic substrate
Even；
Upper surface direction bending of the microneedle array from root towards the metallic substrates；
Electrode button is connected to the lower surface of the metallic substrates；
Medical application is fitted in the periphery of the metallic substrates upper surface.
2. the preparation method according to claim 1, it is characterised in that cut out double-deck hangnail knot on the metallic substrate
The microneedle array of structure.
3. the preparation method according to claim 1 or 2, it is characterised in that the material of the metallic substrates be with
The medical stainless steel of biocompatibility.
4. the preparation method according to claim 3, it is characterised in that using laser processing it is described it is medical not
The microneedle configuration with double-deck barb structure is cut out on rust steel.
5. the preparation method according to claim 4, it is characterised in that the height of the micropin of the microneedle array is
300-700 μm, the spacing between each micropin needle point is 0.5-1 mm.
6. the preparation method according to claim 5, it is characterised in that be connected to electrode button using welding method
The lower surface of the metallic substrates.
7. the microneedle array that the preparation method of any microneedle array electrode makes in a kind of use the claims 1 to 6
Electrode, it is characterised in that including：Microneedle array with barb structure, the microneedle array is by metallic substrates cutting
Into the microneedle array intersects with the upper surface of the metallic substrates in the root of the microneedle array；Electrode button with it is described
The lower surface connection of metallic substrates, medical application is fitted in the periphery of the metallic substrates upper surface.
8. the microneedle array electrode according to claim 7, it is characterised in that the microneedle array is double-deck hangnail knot
Structure.
9. the microneedle array electrode according to claim 7 or 8, it is characterised in that the material of the metallic substrates is
Medical stainless steel with biocompatibility.
10. the microneedle array electrode according to claim 9, it is characterised in that the height of the micropin of the microneedle array
It it is 300-700 μm, the spacing between each micropin is 0.5-1 mm.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710091902.4A CN106808162A (en) | 2017-02-21 | 2017-02-21 | A kind of microneedle array electrode and preparation method thereof |
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| CN201710091902.4A CN106808162A (en) | 2017-02-21 | 2017-02-21 | A kind of microneedle array electrode and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111317911A (en) * | 2020-02-28 | 2020-06-23 | 广东工业大学 | Novel microneedle and manufacturing method thereof |
| CN112316292A (en) * | 2020-07-26 | 2021-02-05 | 浙江工业大学 | Bionic microneedle patch for transdermal drug delivery |
| CN112618945A (en) * | 2020-12-14 | 2021-04-09 | 北京航空航天大学 | Hollow closed type microneedle, preparation method thereof and operating device comprising microneedle |
| CN114432587A (en) * | 2021-12-14 | 2022-05-06 | 优微（珠海）生物科技有限公司 | Microneedle patch |
| WO2023109633A1 (en) * | 2021-12-14 | 2023-06-22 | 优微（珠海）生物科技有限公司 | Microneedle patch, microneedle mold and manufacturing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112316292A (en) * | 2020-07-26 | 2021-02-05 | 浙江工业大学 | Bionic microneedle patch for transdermal drug delivery |
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| CN114432587A (en) * | 2021-12-14 | 2022-05-06 | 优微（珠海）生物科技有限公司 | Microneedle patch |
| WO2023109633A1 (en) * | 2021-12-14 | 2023-06-22 | 优微（珠海）生物科技有限公司 | Microneedle patch, microneedle mold and manufacturing method |
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Application publication date: 20170609 |