CN106728580A - Hypoglycemic capsule of compound konjaku and preparation method thereof - Google Patents
Hypoglycemic capsule of compound konjaku and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to hypoglycemic arts, and in particular to the hypoglycemic capsule of compound konjaku, the preparation method of the capsule is further related to.The hypoglycemic capsule of compound konjaku of the invention, described capsule includes the component of following portions by weight：Konjaku powder：300 400 parts, bee glue powder：100 200 parts, chromium picolinate：0.5 1 parts.Be combined for konjaku powder, bee glue powder, chromium picolinate this three by the present invention, and collective effect has reached the effect for effectively reducing blood sugar.The present invention is under instruction of Chinese Medicine theory, on the basis of scientific appraisal and experiment, hard shell capsules to be made with the constituent optimization formula such as konjaku powder, propolis.Then carry out correlation function experiment and toxicological evaluation research, it was confirmed that it is the hypoglycemic capsule of compound konjaku that a kind of safety non-toxic has notable function of blood sugar reduction.
Description
Technical field
The invention belongs to hypoglycemic arts, and in particular to the hypoglycemic capsule of compound konjaku, the system of the capsule is further related to
Preparation Method.
Background technology
Diabetes (Diabetes Mellitus, DM) are a kind of common by glucose metabolism disorders and dysendocrinism
The disease of the generalized metabolic disorder for causing, is also a kind of chronic, lifelong participation, refractory disease, and its complication can involve whole body
Each internal organs organ, the quality of life of serious infringement patient, can finally disable, or even jeopardize the life of patient.Current China suffers from
The total number of persons of diabetes up to 92,400,000, as the global big country of diabetic's number first.According to WHO statistics, whole world sugar
Urine patient is existing, and oneself exceedes 1.94 hundred million, as the mankind dead killer of the 3rd.
The hypoglycemic medicine used by clinic, can also cure without a kind of effective medicine or means at present, can only control blood sugar
Certain scope is reached, so as to reduce and delay the generation of complication.Existing market oral hypoglycemic drug has three major types：Sulfonylurea
Class, biguanides and alpha-glucosidase restrainer.But these medicines are most all with toxic and side effect, patient is big after taking
Some adverse reactions, such as allergy, hypoglycemia, gastrointestinal reaction, infringement liver, arrhythmia cordis, PVR can be produced
The side effect such as rise with body weight, psychological burden is caused after long-term use these medicines.
Research in recent years confirms that traditional Chinese medicine shows one in terms of improving symptom, improving life quality, treat complication
Fixed advantage, meanwhile, traditional Chinese medicine also shows the many-sided, adjustment effect of too many levels to diabetic.In controlling for diabetes
In treatment, can be promoting blood circulation and removing blood stasis with the ingenious combination of supplementing qi and nourishing yin medicine, so that diabetes are fundamentally effectively treated, can
Prevention diabetes and its complication develop, and can improve the quality of life of diabetic, are good auxiliary of diabetes
Help medicine.
The A of CN 102949587 disclose a kind of compound propolis preparation of auxiliary hyperglycemic, it is characterized in that, its raw material by
Bee glue powder, sealwort powder, kudzu-vine root powder, medlar powder, royal jelly freeze-dried powder are constituted, the raw material weight percentage in described preparation
It is bee glue powder accounting 40%-55%；Sealwort powder, kudzu-vine root powder, medlar powder mixed powder accounting 35%-45%, royal jelly are freezed
Powder accounting 5%-10%.Its preparation method, it comprises the following steps：
(1) bee glue powder of the weight proportion is weighed, and by 120 mesh screens, it is standby；
(2) sealwort powder, kudzu-vine root powder, the medlar powder of the weight proportion are weighed, it is standby by 100 mesh screens；
(3) royal jelly freeze-dried powder of the weight proportion is weighed, it is standby by 100 mesh screens；
(4) it is 20-25 DEG C in room temperature, under humidity is less than 40% environmental condition, first by Huang standby after above-mentioned sieving
Fine powder, kudzu-vine root powder, medlar powder are put into mixing tank, after being sufficiently stirred for, standby bee glue powder after the above-mentioned sieving of input, then
After being sufficiently stirred for, standby royal jelly freeze-dried powder after above-mentioned sieving is added, after being sufficiently stirred for, mixing, be made content；
(5) it is 20-25 DEG C in room temperature, under humidity is less than 40% environmental condition, is conventionally filled into capsule
Preparation.
Above-mentioned document discloses obtained auxiliary hyperglycemic system after propolis is combined with sealwort powder, kudzu-vine root powder, medlar powder
Agent, said preparation does not disclose its hypoglycemic specific effect, such as clinical trial etc..
CN1507865A discloses a kind of diabetes medicament containing chromium picolinate, it is characterised in that described medicine
It is made up of three chromium picolinates and medical carrier, wherein, in described medicine, three described chromium picolinates account for described medicine
Thing percentage by weight between 0.1-99%, balance of described medical carrier.Above-mentioned medicine is compareed with prior art, and pair is made
With small, the level of blood sugar can be substantially reduced.But how do not disclose its specific effect yet.
The A of CN 102302520 disclose the group of composition of chromium malate and propolis and application thereof, chromium malate and propolis
Compound, it is characterised in that be made up of chromium malate and propolis, by weight component chromium malate are 17~102 parts, propolis extract
It is 500~3000 parts.The composition that above-mentioned method has the chromium malate and propolis being related to has obvious hypoglycemic activity,
And it is more preferable compared with the chromium malate or the blood sugar decreasing effect of propolis extract being used alone.Chromium malate of the present invention and
There is not obvious acute toxic reaction in the composition of propolis, and actual nontoxic level is reached to chmice acute Oral toxicity.Can be used for
Treat and prevent the medicine or functional food of diabetes.
Whether konjaku powder can be combined with above-mentioned raw material, and combine after whether can also reach it is same or
More excellent effect, above-mentioned file is not disclosed.
The content of the invention
In order to solve above-mentioned technical problem, the invention provides a kind of compound konjaku that can effectively reduce blood glucose value
Hypoglycemic capsule.
The hypoglycemic capsule of compound konjaku of the invention includes the component of following portions by weight：
Konjaku powder：300-400 parts
Bee glue powder：100-200 parts
Chromium picolinate：0.5-1 parts.
Preferably, the component of the hypoglycemic capsule of compound konjaku of the invention, including following portions by weight：
Konjaku powder：350 parts
Bee glue powder：180 parts
Chromium picolinate：0.7 part.
The preparation method of the hypoglycemic capsule of compound konjaku of the invention, including following steps：
(1) pretreatment of raw material：
Take konjaku powder, bee glue powder, chromium picolinate；
(2) mix：
The bee glue powder and chromium picolinate in step (1) are pre-mixed by equal increments method, are then mixed with konjaku powder；
(3) capsule is prepared
The raw material mixed in step (2) is taken, feeding capsule filled chamber carries out capsule filling, and capsule charge room is protected with mistress
Negative relative is held, dust is excluded by dust exhaust apparatus, 18-26 DEG C of indoor control, relative humidity 45-65%, obtain compound konjaku drop blood
Carbohydrate gum capsule.
As a modification of the present invention, by polishing in the capsule addition capsule polisher hopper in step (3), will
Tack, flat head, crackle, the defective work of empty pocket are picked out.
Preferably, above-mentioned raw material konjaku powder, bee glue powder, chromium picolinate were the raw material taken after 80 mesh sieves.
The bee glue powder being pre-mixed by equal increments method in above-mentioned step (2) is mixed with chromium picolinate and konjaku powder
Time be 20-40 minutes.
The disintegration time limited of filling capsule in above-mentioned step (3)：≤30min.
The preparation method of konjaku powder is as follows：
A takes fresh clean fresh Amorphophallus rivieri, peeling, stripping and slicing, after then mixing with ethanol solution together with put into pulverizer
Middle crushing, while adding effective SO2Concentration is the sulfite solution of 25mg/L~100mg/L；Ethanol solution is fresh Amorphophallus rivieri
1-3 times of weight, the concentration of ethanol is more than or equal to 30% in material；By further powder in the material feeding emery wheel mill after crushing
It is broken；
B by material centrifuge of the input with filter screen in step a through emery wheel milling after broken, solable matter and little particle
Impurity is isolated through filter screen with solvent under the influence of centrifugal force, and konjaku powder is stayed on filter screen, then is taken volumetric concentration and be
Be vacuum dried for the konjaku powder of gained by the konjaku powder in 30% ethanol solution washing filter screen, centrifugation；
C will be put into pot for solvent extraction by the dried konjaku powders of step b, add volumetric concentration to be more than or equal to 30%
Ethanol solution extraction, then through kibbling mill grind, be delivered to cyclone hydraulic separators, isolate starch, pigment, inorganic salts；Again plus
Enter ethanol solution cleaning, centrifugation that volumetric concentration is 30%, grinder grinding, centrifugal dehydration, microwave drying.
Konjaku powder indices above are as follows：
Product purity >=90.5%；Viscosity >=28000mPaS；Moisture≤10.0%；Ash content≤3%；Silt content≤
0.04%.
Research shows that konjak glucomannan (Konjac Glucomannan, KGM) has 80-100 times of expansion system
Number, viscosity is high, reduces glucose resultant index, delays and reduce the absorption of sugar, improves the sensitiveness of insulin, reduces human body
Sugar tolerance, so as to adjust the insulin balance of the person of eating, mitigates the burden of pancreas islet, diabetic benign is followed into one
Ring.
Propolis contains the materials such as the flavonoids with hypoglycemic activity, terpenes, can reduce blood sugar and prevent diabetes
Complication, and Chinese Pharmacopoeia also specifies that it can be used for the auxiliary treatment of diabetes for 2015 in version.Its mechanism is to promote
Exogenous glucose synthesizes the effect of hepatic glycogen and bidirectional modulation blood sugar, removes interior free yl, repairs impaired beta Cell of islet work(
, can stimulate insulin secretion, improve insulin resistance and glucose -lipid metabolism disorder so as to reduce the function of blood sugar.
Chromium picolinate is mammal liver, nephrogenous amino acid metabolites, there is hypoglycemic function.Cr3+It is
The important composition composition of GTF, GTF is Cr3+, niacin and glutathione complex compound, be
The cofactor of insulin, can strengthen activity of islet cells, improve insulin receptor activity, stimulate peripheral tissues to glucose
Intake, accelerate the transhipment of glucose in serum, improve the normal level that sugar tolerance and glycometabolism maintain blood sugar.
The beneficial effects of the present invention are, be combined for konjaku powder, bee glue powder, chromium picolinate this three by the present invention,
Collective effect, has reached the effect for effectively reducing blood sugar.The present invention be under instruction of Chinese Medicine theory, and with《The Chinese people are total to
With state's pharmacopeia》And modern pharmacological research scientific research document is foundation, on the basis of scientific appraisal and experiment, with konjaku essence
The constituent optimization formula such as powder, bee glue powder, chromium picolinate is made hard shell capsules.Then carry out correlation function experiment and toxicology is commented
Valency is studied, it was confirmed that it is the hypoglycemic capsule of compound konjaku that a kind of safety non-toxic has notable function of blood sugar reduction.
Specific embodiment
The present invention is further described with reference to specific embodiment, so that those skilled in the art knows more about
The present invention, but and it is not so limited the present invention.
Embodiment 1
The preparation method of the hypoglycemic capsule of compound konjaku, including following steps：
(1) pretreatment of raw material：
Take 350 parts of konjaku powders, 180 parts of bee glue powders, 0.7 part of chromium picolinate and (parts by weight are, in following examples
But specified otherwise, is parts by weight)；Raw material konjaku powder, bee glue powder, chromium picolinate were after 80 mesh sieves what is taken
Raw material；
The preparation method of konjaku powder is as follows：
A takes fresh clean fresh Amorphophallus rivieri, peeling, stripping and slicing, after then mixing with ethanol solution together with put into pulverizer
Middle crushing, while adding effective SO2Concentration is the sulfite solution of 25mg/L~100mg/L；Ethanol solution is fresh Amorphophallus rivieri
1-3 times of weight, the concentration of ethanol is more than or equal to 30% in material；By further powder in the material feeding emery wheel mill after crushing
It is broken；
B by material centrifuge of the input with filter screen in step a through emery wheel milling after broken, solable matter and little particle
Impurity is isolated through filter screen with solvent under the influence of centrifugal force, and konjaku powder is stayed on filter screen, then is taken volumetric concentration and be
Be vacuum dried for the konjaku powder of gained by the konjaku powder in 30% ethanol solution washing filter screen, centrifugation；
C will be put into pot for solvent extraction by the dried konjaku powders of step b, add volumetric concentration to be more than or equal to 30%
Ethanol solution extraction, then through kibbling mill grind, be delivered to cyclone hydraulic separators, isolate starch, pigment, inorganic salts；Again plus
Enter ethanol solution cleaning, centrifugation that volumetric concentration is 30%, grinder grinding, centrifugal dehydration, microwave drying.
Konjaku powder indices above are as follows：
Product purity 90.7%；Viscosity 28300mPaS；Moisture 9.6%；Ash content 2.4%；Silt content 0.03%.
(2) mix：
The bee glue powder and chromium picolinate in step (1) are pre-mixed by equal increments method, are then mixed with konjaku powder；
The time that the bee glue powder being pre-mixed by equal increments method in step (2) is mixed with chromium picolinate and konjaku powder is 30 points
Clock；
(3) capsule is prepared
The raw material mixed in step (2) is taken, feeding capsule filled chamber carries out capsule filling, and capsule charge room is protected with mistress
Negative relative is held, dust is excluded by dust exhaust apparatus, and 22 DEG C of indoor control, relative humidity 50% or so obtains compound konjaku hypoglycemic
Capsule；
By polishing in capsule addition capsule polisher hopper, the defective work of tack, flat head, crackle, empty pocket is picked
Go out；
Fill the disintegration time limited of capsule：≤30min.
Experiment one, stability experiment is investigated
According to《Health food Evaluation technology code》, three batches of samples are taken respectively, put 37-40 DEG C, 75% relative humidity bar
Deposited three months under part, in before storage, full one month of storage, storage be full two months, storage is full three months, and three batches of examinations are detected respectively
The important indicator of the product inherent quality is represented in sample, is detected four times altogether, investigate data as follows：
The effective component stable content of table 1 investigates data
Experimental result shows that the present invention meets in stability《Health food Evaluation technology code》, better than prior art.
Experiment two, Safety and toxicology experimental study
2.1 acute toxicity testings
Select 20 SPF grades of ICR mouse (male and female half and half, 18~22g of body weight), according to maximal tolerance dose (MTD) method test into
OK.The solution that given the test agent distilled water is configured to final concentration of 0.50g/mL is weighed, gavage gives in three times, be spaced 4h, often
Secondary gavage amount is 0.2mL/10gbw, and it is 20.0g/kgbw to add up poisoning dosage.Empty stomach 16h is standby before experiment (does not limit drink
Water), weigh, after gavage gives tested material, record the poisoning manifestations and death condition of mouse, Continuous Observation 14d.Calculate body weight equal
Value and standard deviation, the death rate etc..
The Mouse Acute Toxicity experimental result of table 2
The acute toxicity tests show that after gavage gives compound Pueraria lobota capsule, each group mouse diet, activity are in just
Normal state, it is grown does not influence, and has no in obvious poisoning symptom, 14d death condition do not occur, shows compound Pueraria lobota capsule
MTD to two kinds of sex mouse is all higher than 20g/kgbw.According to acute toxicity grading criteria, compound Pueraria lobota capsule belongs to nontoxic
Level.
2.2 30d feeding trials
80 SPF grades of SD rats (male and female half and half, 63~84g of body weight) are selected, 4 groups, every group 20 are randomly divided into.Experiment is by receiving
25,50 and 100 times of examination thing human body recommended amounts, if 3 dosage groups are respectively 0.67,1.33 and 2.67g/kgbw, if distillation
Water negative control group, each group rat is given by 1mL/100gbw dosage gavages, and one time a day, continues 30d.Claim 1 body weight weekly
With 2 food intake doses, total foodstuff utilization rate is calculated.In the 31st day fasting 16h is tested, rat is put to death, taking blood carries out blood
Learn and blood biochemical analysis index determining, calculate organ coefficient, carry out gross examination and histopathological examination.Its test data point
3,4,5,6 are not shown in Table.
The rat 30d feeding trials of table 3 to rat total foodstuff utilization rate influence (N=20)
The rat 30d feeding trial latter stage hematological examinations result of table 4 (N=20)
The rat 30d feeding trial latter stage blood biochemical analysis index determinings result of table 5 (N=20)
Note：*P<0.05 (comparing with control group)
The rat 30d feeding trial latter stage blood biochemical analysis index determinings result of continued 5 (N=20)
The dirty body of rat 30d feeding trials of table 6 than measurement result (N=20)
In order, there is not poisoning sign and death in each test group SD rats overall growth in the 30d feeding trial cycles
Situation.Each test group SD rat growthing developments are good in the rat 30d feeding trial phases, weight gain, food utilization, internal organs system
In range of normal value, each test group SD rat bloods and blood biochemical analysis index are in normal value model for the indices such as number
In enclosing, the tested internal organs of each test group SD rats of gross anatomy and histopathologic examination are showed no significant pathological change.Greatly
Mouse 30d feeding trial results show that compound Pueraria lobota capsule does not make significant difference to the growth of rat, development and health status, without latent
Toxicity.
Comparative example 1：The combination of konjaku powder+bee glue powder；
Its preparation method is：
(1) pretreatment of raw material：
Take 350 parts of konjaku powders, 180.7 parts of bee glue powders；Raw material konjaku powder, bee glue powder were after 80 mesh sieves what is taken
Raw material；
(2) mix：
Bee glue powder in blend step (1) is mixed with konjaku powder；Bee glue powder is with the time that konjaku powder is mixed
30 minutes；
(3) capsule is prepared
The raw material mixed in step (2) is taken, feeding capsule filled chamber carries out capsule filling, and capsule charge room is protected with mistress
Negative relative is held, dust is excluded by dust exhaust apparatus, and 22 DEG C of indoor control, relative humidity 50% or so obtains compound konjaku hypoglycemic
Capsule；
By polishing in capsule addition capsule polisher hopper, the defective work of tack, flat head, crackle, empty pocket is picked
Go out；
Fill the disintegration time limited of capsule：≤30min.
Comparative example 2：Bee glue powder+chromium picolinate；
Its preparation method is：
(1) pretreatment of raw material：
Take 530 parts of bee glue powders, 0.7 part of chromium picolinate；Raw material bee glue powder, chromium picolinate were taken after being 80 mesh sieves
Raw material；
(2) mix：
Bee glue powder and chromium picolinate in blend step (1), bee glue powder are 30 with the time that chromium picolinate is mixed
Minute；
(3) capsule is prepared
The raw material mixed in step (2) is taken, feeding capsule filled chamber carries out capsule filling, and capsule charge room is protected with mistress
Negative relative is held, dust is excluded by dust exhaust apparatus, and 22 DEG C of indoor control, relative humidity 50% or so obtains the hypoglycemic capsule of compound；
By polishing in capsule addition capsule polisher hopper, the defective work of tack, flat head, crackle, empty pocket is picked
Go out；
Fill the disintegration time limited of capsule：≤30min.
Comparative example 3：Konjaku powder+chromium picolinate；
Its preparation method is：
(1) pretreatment of raw material：
Take 530 parts of konjaku powders, 0.7 part of chromium picolinate；Raw material konjaku powder, bee glue powder, chromium picolinate were
The raw material taken after 80 mesh sieves；
(2) mix：
Konjaku powder and chromium picolinate in blend step (1), the time that konjaku powder is mixed with chromium picolinate
It is 30 minutes；
(3) capsule is prepared
The raw material mixed in step (2) is taken, feeding capsule filled chamber carries out capsule filling, and capsule charge room is protected with mistress
Negative relative is held, dust is excluded by dust exhaust apparatus, and 22 DEG C of indoor control, relative humidity 50% or so obtains compound konjaku hypoglycemic
Capsule；
By polishing in capsule addition capsule polisher hopper, the defective work of tack, flat head, crackle, empty pocket is picked
Go out；
Fill the disintegration time limited of capsule：≤30min.
Comparative example 4：Konjaku powder+bee glue powder+chromium malate；
Its preparation method is：
(1) pretreatment of raw material：
Take 350 parts of konjaku powders, 180 parts of bee glue powders, 0.7 part of chromium malate；Raw material konjaku powder, bee glue powder, malic acid
Chromium was the raw material taken after 80 mesh sieves；
(2) mix：
The bee glue powder and chromium malate in step (1) are pre-mixed by equal increments method, are then mixed with konjaku powder；Step
Suddenly the time that the bee glue powder being pre-mixed by equal increments method in (2) is mixed with chromium malate and konjaku powder is 30 minutes；
(3) capsule is prepared
The raw material mixed in step (2) is taken, feeding capsule filled chamber carries out capsule filling, and capsule charge room is protected with mistress
Negative relative is held, dust is excluded by dust exhaust apparatus, and 22 DEG C of indoor control, relative humidity 50% or so obtains compound konjaku hypoglycemic
Capsule；
By polishing in capsule addition capsule polisher hopper, the defective work of tack, flat head, crackle, empty pocket is picked
Go out；
Fill the disintegration time limited of capsule：≤30min.
Comparative example 5：Konjaku powder+bee glue powder+glossy ganoderma powder；
Its preparation method is：
(1) pretreatment of raw material：
Take 350 parts of konjaku powders, 180 parts of bee glue powders, 0.7 part of glossy ganoderma powder；Raw material konjaku powder, bee glue powder, glossy ganoderma powder are equal
To cross the raw material taken after 80 mesh sieves；
(2) mix：
Bee glue powder and glossy ganoderma powder in step (1) are pre-mixed by equal increments method, are then mixed with konjaku powder；Step
(2) time that the bee glue powder being pre-mixed by equal increments method in is mixed with glossy ganoderma powder and konjaku powder is 30 minutes；
(3) capsule is prepared
The raw material mixed in step (2) is taken, feeding capsule filled chamber carries out capsule filling, and capsule charge room is protected with mistress
Negative relative is held, dust is excluded by dust exhaust apparatus, and 22 DEG C of indoor control, relative humidity 50% or so obtains compound konjaku hypoglycemic
Capsule；
By polishing in capsule addition capsule polisher hopper, the defective work of tack, flat head, crackle, empty pocket is picked
Go out；
Fill the disintegration time limited of capsule：≤30min.
Comparative example 6：Common commercially available konjaku powder+bee glue powder+pyridine acid chrome；Commercially available konjaku powder is only substituted into this hair
Bright konjaku powder, remaining is identical.
Influence of the product of the present invention and comparative example 1-6 to glucose tolerance in mice
SPF grades of health ICR mouse (female, 24~28g of body weight) 70 is taken, is induced using tail vein injection alloxan and made
Standby hyperglycaemia mouse model, 7 groups, respectively control group, the product group of embodiment 1, comparative example 1-5 products are randomly divided into by mouse
Group.Respective sample is configured to the solution that concentration is 13.5mg/mL respectively, sample each group presses 20mL/kgbw gavages, compares
Group gives the distilled water of same dose, once a day, continues 30d.Each group mouse fasting 5h, determines to glucose during off-test
Before (i.e. 0h) blood glucose value, control group gives same volume distilled water, and each group presses 2.0g/kgbw oral administration of glucose after 20min,
Take blood glucose value of the tail hematometry to each group after glucose 0.5,2h, observation control group and each sample solution group to it is each after glucose when
Between point (0,0.5,2h) blood glucose value and Area under the curve of blood glucose change, result of the test is as shown in the table：
As can be seen that the konjaku powder, bee glue powder, the pyridine first that match specified weight in the present invention in data more than
Sour chromium is combined, and its blood sugar decreasing effect will significantly be better than the combination in documents 1-6, for example：Only by konjaku powder, honeybee
Rubber powder is combined, the effect that konjaku powder+bee glue powder+glossy ganoderma powder is combined, and above-mentioned effect is not what is be expected, is
The present inventor has been paid obtained by performing creative labour.
Embodiment 2
(1) pretreatment of raw material：
Take 300 parts of konjaku powders, 100 parts of bee glue powders, 0.5 part of chromium picolinate and (parts by weight are, in following examples
But specified otherwise, is parts by weight)；Raw material konjaku powder, bee glue powder, chromium picolinate were after 80 mesh sieves what is taken
Raw material；
The preparation method of konjaku powder is with embodiment 1；
(2) mix：
The bee glue powder and chromium picolinate in step (1) are pre-mixed by equal increments method, are then mixed with konjaku powder；
The time that the bee glue powder being pre-mixed by equal increments method in step (2) is mixed with chromium picolinate and konjaku powder is 20 points
Clock；
(3) capsule is prepared
The raw material mixed in step (2) is taken, feeding capsule filled chamber carries out capsule filling, and capsule charge room is protected with mistress
Negative relative is held, dust is excluded by dust exhaust apparatus, and 18 DEG C of indoor control, relative humidity 45% or so obtains compound konjaku hypoglycemic
Capsule；
By polishing in capsule addition capsule polisher hopper, the defective work of tack, flat head, crackle, empty pocket is picked
Go out；
Fill the disintegration time limited of capsule：≤30min.
Embodiment 3
(1) pretreatment of raw material：
Take 400 parts of konjaku powders, 200 parts of bee glue powders, 1 part of chromium picolinate and (be parts by weight, nothing in following examples
Such as specified otherwise, parts by weight are)；Raw material konjaku powder, bee glue powder, chromium picolinate were the original taken after 80 mesh sieves
Material；
The preparation method of konjaku powder is with embodiment 1；
(2) mix：
The bee glue powder and chromium picolinate in step (1) are pre-mixed by equal increments method, are then mixed with konjaku powder；
The time that the bee glue powder being pre-mixed by equal increments method in step (2) is mixed with chromium picolinate and konjaku powder is 40 points
Clock；
(3) capsule is prepared
The raw material mixed in step (2) is taken, feeding capsule filled chamber carries out capsule filling, and capsule charge room is protected with mistress
Negative relative is held, dust is excluded by dust exhaust apparatus, and 26 DEG C of indoor control, relative humidity 65% or so obtains compound konjaku hypoglycemic
Capsule；
By polishing in capsule addition capsule polisher hopper, the defective work of tack, flat head, crackle, empty pocket is picked
Go out；
Fill the disintegration time limited of capsule：≤30min.
Claims (9)
1. the hypoglycemic capsule of compound konjaku, it is characterised in that described capsule includes the component of following portions by weight：
Konjaku powder：300-400 parts
Bee glue powder：100-200 parts
Chromium picolinate：0.5-1 parts.
2. the hypoglycemic capsule of compound konjaku as claimed in claim 1, it is characterised in that described capsule includes following weight parts
Several components：
Konjaku powder：350 parts
Bee glue powder：180 parts
Chromium picolinate：0.7 part.
3. the preparation method of the hypoglycemic capsule of compound konjaku as claimed in claim 1, including following steps：
(1) pretreatment of raw material：
Take konjaku powder, bee glue powder, chromium picolinate；
(2) mix：
The bee glue powder and chromium picolinate in step (1) are pre-mixed by equal increments method, are then mixed with konjaku powder；
(3) capsule is prepared
The raw material mixed in step (2) is taken, feeding capsule filled chamber carries out capsule filling, and capsule charge room keeps phase with mistress
To negative pressure, dust is excluded by dust exhaust apparatus, and 18-26 DEG C of indoor control, relative humidity 45-65% obtains the hypoglycemic glue of compound konjaku
Capsule.
4. the preparation method of the hypoglycemic capsule of compound konjaku as claimed in claim 3, it is characterised in that by step (3)
Capsule adds polishing in capsule polisher hopper, and the defective work of tack, flat head, crackle, empty pocket is picked out.
5. the preparation method of the hypoglycemic capsule of compound konjaku as claimed in claim 3, it is characterised in that described raw material konjaku
Fine powder, bee glue powder, chromium picolinate were the raw material taken after 80 mesh sieves.
6. the preparation method of the hypoglycemic capsule of compound konjaku as claimed in claim 3, it is characterised in that described step (2)
In time for mixing of the bee glue powder and chromium picolinate and the konjaku powder that are pre-mixed by equal increments method be 20-40 minutes.
7. the preparation method of the hypoglycemic capsule of compound konjaku as claimed in claim 3, it is characterised in that described step (3)
The disintegration time limited of middle filling capsule：≤30min.
8. the preparation method of the hypoglycemic capsule of compound konjaku as claimed in claim 3, it is characterised in that described konjaku powder
Purity >=90.5%；(2) viscosity >=28000mPaS.
9. the preparation method of the hypoglycemic capsule of compound konjaku as claimed in claim 3, it is characterised in that described konjaku powder
Preparation method it is as follows：
A takes fresh clean fresh Amorphophallus rivieri, peeling, stripping and slicing, after then mixing with ethanol solution together with put into pulverizer powder
It is broken, while adding effective SO2Concentration is the sulfite solution of 25mg/L~100mg/L；Ethanol solution is the weight of fresh Amorphophallus rivieri
1-3 times, in material the concentration of ethanol be more than or equal to 30%；To further be crushed in material feeding emery wheel mill after crushing；
B by material centrifuge of the input with filter screen in step a through emery wheel milling after broken, solable matter and little particle impurity
Isolated with solvent through filter screen under the influence of centrifugal force, konjaku powder is stayed on filter screen, then it is 30% to take volumetric concentration
Be vacuum dried for the konjaku powder of gained by the konjaku powder in ethanol solution washing filter screen, centrifugation；
C will be put into pot for solvent extraction by the dried konjaku powders of step b, add second of the volumetric concentration more than or equal to 30%
Alcoholic solution is extracted, and is then ground through kibbling mill, is delivered to cyclone hydraulic separators, isolates starch, pigment, inorganic salts；Add body
Product concentration is 30% ethanol solution cleaning, centrifugation, grinder grinding, centrifugal dehydration, microwave drying.
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| CN201710015799.5A CN106728580A (en) | 2017-01-10 | 2017-01-10 | Hypoglycemic capsule of compound konjaku and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107136512A (en) * | 2017-07-10 | 2017-09-08 | 湖南七纬科技有限公司 | A kind of vinegar capsule of auxiliary hyperglycemic reducing blood lipid and preparation method thereof |
| CN107412334A (en) * | 2017-09-06 | 2017-12-01 | 湖北厚品生物科技有限公司 | Compound control sugar mixture and its manufacture method |
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| CN101450095A (en) * | 2007-11-30 | 2009-06-10 | 北京因科瑞斯医药科技有限公司 | Medicine composition with blood-sugar reduction function and preparation method thereof |
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| CN107136512A (en) * | 2017-07-10 | 2017-09-08 | 湖南七纬科技有限公司 | A kind of vinegar capsule of auxiliary hyperglycemic reducing blood lipid and preparation method thereof |
| CN107412334A (en) * | 2017-09-06 | 2017-12-01 | 湖北厚品生物科技有限公司 | Compound control sugar mixture and its manufacture method |
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