CN106726987A - A kind of inhibiting bacteria and diminishing inflammation composition and its application - Google Patents
A kind of inhibiting bacteria and diminishing inflammation composition and its application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses a kind of inhibiting bacteria and diminishing inflammation composition, the duplication of retrovirus is effectively suppressed by hypericum perforatum flower extract in composition；The significant anti-oxidant, anti-aging effects of black extract of mulberry twig；Spearmint essential oil promotes the healing of inflammation skin, and three kinds of composition compoundings, synergy can reach excellent inhibiting bacteria and diminishing inflammation, anti-aging effects.And apply in face cream composition, safety does not stimulate gently, assigns face cream excellent inhibiting bacteria and diminishing inflammation, anti-aging, effect of moisturizing.
Description
Technical field
The present invention relates to cosmetic field, and in particular to a kind of inhibiting bacteria and diminishing inflammation composition and its application.
Background technology
Inflammation refers to the defense reaction that body occurs to damage factor, and it can come from body outside such as bacterium, virus
Or wound, foreign matter etc., it is also possible to from internal body such as slough, allergy etc..Can be caused when inflammatory reaction is excessive
Body damage, causes the skin problems such as appearance is red and swollen, peels, fester.According to incompletely statistics, west 80% teenager and
50% adult has different degrees of acne, and almost 95% Chinese face is long has " whelk ", and 55% people
Long-term acne long, and the mechanism of acne long be exactly the aliphatic acid that excessive sebum metabolism is produced stimulation and enclosed environment in excessively increase
The effect of the propionibacterium acnes grown, rubescent and suppuration small pox causes skin to generate inflammation with the presence of bacterium infection
Reaction.
Chinese patent storehouse discloses a kind of medicine (CN1626139A) for inhibiting bacteria and diminishing inflammation, by Tinidazole, auxiliary material, tween
80 grades are into being grouped into.The inhibiting bacteria and diminishing inflammation medicine has certain side effect, disables in pregnant woman.Chinese patent storehouse discloses a kind of moisturizing and disappears
Scorching toner (CN104688609A), including anti-inflammation liquid 5-7 parts, collagen liquid 6-8 parts, olive oil 2-4 parts, essence 0.1-
The composition such as 0.3 part, panthenol 0.2-0.4 parts and coenzyme 0.3-0.5 parts, the invention primary efficacy is moisturizing, and anti-inflammatory effects are failed to understand
It is aobvious, the being irritating to the skin property such as essence, panthenol.
Current oral inhibiting bacteria and diminishing inflammation product on the market, mostly antibacterials, such as antibiotic, long-term taking, can cause
Drug resistance, it is unhealthful；It is big to there is excitant in the inhibiting bacteria and diminishing inflammation product of skin, the problems such as DeGrain, causes inflammation repeatedly
Breaking-out, destroys the microecological balance of skin.
The content of the invention
Stimulate big for existing inhibiting bacteria and diminishing inflammation product, the problem of DeGrain.It is an object of the invention to provide one kind
Inhibiting bacteria and diminishing inflammation composition and its application, it is gentle, and excitant is small, and is added in face cream so that face cream has significant suppression
Bacterium anti-inflammatory, anti-aging effects.
To solve the above problems, there is provided following solution：
A kind of inhibiting bacteria and diminishing inflammation composition, consists of the following composition：Hypericum perforatum flower extract, black extract of mulberry twig, stays orchid
Essential oil.
Preferably, the weight part ratio of each composition of inhibiting bacteria and diminishing inflammation composition is (1-10)：(2-10)：(0.1-1).
Preferably, the weight portion of each composition of inhibiting bacteria and diminishing inflammation composition is：It is 0.1-1 parts of hypericum perforatum flower extract, black
Extract of mulberry twig 0.2-0.8 parts, spearmint essential oil 0.01-0.08 parts.
The preparation method of the hypericum perforatum flower extract is as follows：Hypericum perforatum flower petal is taken, 75-90% ethanol solutions are used
Refluxing extraction 2-3 times, merges extract solution, is concentrated under reduced pressure, 8000-9000r/min centrifugations, takes supernatant；Supernatant injection is big
Macroporous adsorbent resin post, with 20-50% ethanol elution impurity, then uses 60-85% ethanol elutions, reclaims eluent, spray drying, system
Obtain dry extract, i.e., described hypericum perforatum flower extract.
The preparation method of the black extract of mulberry twig is as follows：By black ramulus mori with the ethanol solution of 75-90% at 70-100 DEG C
At a temperature of extract 2-3 time, merging extract solution；Said extracted liquid is adjusted into pH to 7-9,1-2h, 7000-9000r/min is stood
Centrifugation, takes supernatant, adjusts pH to 4-6, goes sediment, washing and drying to obtain the black extract of mulberry twig after standing.
Bacteria inhibiting composition is applied in preparing with inhibiting bacteria and diminishing inflammation, the cosmetics of anti-ageing repair function, the cosmetics
It is face cream.
Further, the face cream includes the composition of following weight portion：Emulsifying agent：3.5-6.3 parts, emollient：5-10 parts,
Antioxidant：0.2-0.8 parts, NMF：5-15 parts, thickener：0.05-0.15 parts, preservative：0.3-0.7 parts, inhibiting bacteria and diminishing inflammation
Composition：0.31-1.88 parts, deionized water is to 100 parts.
The emulsifying agent is cetostearyl alcohol/cetearyl glucoside, cetostearyl alcohol, stearine/PEG-
100 stearates.
The emollient is dimethyl silicone polymer, caprylic/capric triglyceride, hydrogenated jojoba oil.
The antioxidant is tocopherol, is confused the extract that changes.
The NMF is propane diols, glycerine, Sodium Hyaluronate, sorbierite.
The thickener is sodium carboxymethylcellulose.
The preservative is Phenoxyethanol, Sodium Benzoate.
The preparation method of face cream of the present invention is comprised the following steps：Add during emollient, emulsifying agent are added into oil phase pot
To 75-85 DEG C, stirring is incubated stand-by as A phases heat completely；NMF, thickener, deionized water are added in water phase pot, heating
To 75-85 DEG C stirring be incubated completely it is stand-by as B phases；Emulsification pot is preheated to 60-65 degree, 45 revs/min of mixing speed first will
B phases are pumped into, then A phases are pumped into, and are stirred 30 minutes, and temperature is maintained at 85 degree；Homogeneous 3 minutes；Suppression is added after being cooled to 35-45 DEG C
Bacterium anti-inflammatory composition, antioxidant, preservative, insulated and stirred to well mixed, 35 revs/min of mixing speed；Vacuumize discharging.
Fractions of the invention are done with following introduction：
Hypericum perforatum belongs to Garcinia maingayii, containing dry measure used in former times skin quercitrin, vitamin, carrotene, play oil, tannin and resin,
The materials such as hypericin.From hypericum perforatum flower petal in extract hypericum perforatum flower extract, containing benzanthrone compound,
The materials such as phloroglucin compound, flavonoids.Hypericin in benzanthrone compound can suppress the duplication of retrovirus,
Realize its significant antibiotic effect, and Hyperoside in flavone compound has inhibiting bacteria and diminishing inflammation, promotes wound healing
Effect.
Black extract of mulberry twig contains the materials such as black mulberrin, rutin, anthocyanidin, Coumarins.Wherein rutin is to ultraviolet and x
Ray has extremely strong absorption.Modern study shows, the rutin of addition 10%, and the absorptivity of ultraviolet is up to 98%；Anthocyanidin
Oxidation resistance make ascorbic 20 times.Anti-oxidant, anti-ageing in the black extract of mulberry twig of equivalent weight waiting for a long time is found through experiments that
Active material is higher than black mulberry leaf, so doing raw material using black ramulus mori to extract active component.
Spearmint essential oil is extracted from mint plants, and chemical composition has linalool, limonene, laurene, eucalyptus
Tree brain, carvol, menthol etc., but because the content of its menthol is few, so making spearmint essential oil to the excitant of skin
It is small, can apply in juvenile product.Added in cosmetics, there is alleviation pruitus, the effect of muscle of releiving, to Cuo
Sore, dermatitis also has certain curative effect.
The device have the advantages that as follows：(1) hypericum perforatum flower extract effectively suppresses in composition of the invention
The duplication of retrovirus；The significant anti-oxidant, anti-aging effects of black extract of mulberry twig；Spearmint essential oil promotes inflammation skin
Healing, through repetition test, three kinds of active ingredient compoundings, synergy can reach excellent inhibiting bacteria and diminishing inflammation, anti-aging effects；(2)
Emulsifying agent in face cream of the invention, excitant is small, emulsifiability is good；The skin sense of emollient energy improved products so that product parent
Skin sense is good, easily sprawls；Oxidant anti-lipid peroxidation, removes free radical, enhancing by improving the activity of internal antioxidase
The approach of skin collagen layer realizes its antioxidation, further enhances the senile-resistant efficacy of composition；Small molecule glycerine
Deep skin can be penetrated into, the strong Sodium Hyaluronate of compounding water lock moisturizing power, sorbierite, compounding has the propane diols of Penetration enhancing effect,
So that product has splendid moisture-keeping function；(3) raw material of the invention does not stimulate gently, has no side effect；(4) face cream system of the invention
Standby low cost, preparation process is simple has good market value.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
The following component title occurred in text is INCI (Internation Nomenclaure Cosmetic
Ingredent, i.e. international cosmetic raw material name) institute to regulation title：It is cetostearyl alcohol/cetearyl glucoside, sweet
Oleostearin acid esters/PEG-100 stearates, caprylic/capric triglyceride.
The inhibiting bacteria and diminishing inflammation face cream formula of the embodiment of the present invention 1~5 is shown in Table one
Table one
The method method for preparing the inhibiting bacteria and diminishing inflammation face cream of embodiment 1~5 is comprised the following steps：Cetostearyl alcohol/spermaceti is hard
Aliphatic radical glucoside, cetostearyl alcohol, stearine/PEG-100 stearates, dimethyl silicone polymer, caprylic/capric is sweet
Oily three esters, hydrogenated jojoba oil is heated to 75-85 DEG C in adding oil phase pot, and stirring is complete, is incubated stand-by as A phases；By the third two
Alcohol, glycerine, Sodium Hyaluronate, sorbierite, sodium carboxymethylcellulose, deionized water are added in water phase pot, are heated to 75-85 DEG C and are stirred
Mix and be incubated completely stand-by as B phases；Emulsification pot is preheated to 60-65 degree, first be pumped into for B phases by 45 revs/min of mixing speed, then
A phases are pumped into, are stirred 30 minutes, temperature is maintained at 85 degree；Homogeneous 3 minutes；Inhibiting bacteria and diminishing inflammation combination is added after being cooled to 35-45 DEG C
Thing, tocopherol, fan change extract, Phenoxyethanol, Sodium Benzoate, insulated and stirred to well mixed, 35 revs/min of mixing speed；
Vacuumize discharging.
Comparative example 1
It is not add hypericum perforatum flower extract with the difference of embodiment 1, other preparation conditions and method and the phase of embodiment 1
Together.
Comparative example 2
It is not add black extract of mulberry twig with the difference of embodiment 1, other preparation conditions and method are same as Example 1.
Comparative example 3
It is not add spearmint essential oil with the difference of embodiment 1, other preparation conditions and method are same as Example 1.
Comparative example 4
With the difference of embodiment 1 be the parts by weight of inhibiting bacteria and diminishing inflammation composition for 0.3, other preparation conditions and method and reality
Apply example 1 identical.
Comparative example 5
With the difference of embodiment 1 be the parts by weight of inhibiting bacteria and diminishing inflammation composition for 1.89, other preparation conditions and method with
Embodiment 1 is identical.
Suppression experiment to propionibacterium acnes
The generation of acne is mainly blocked with hypersteatosis, pilosebaceous duct, bacterium infection and inflammatory reaction etc.
Factor is closely related.The level of androgen particularly testosterone in descendant's body that adolesces is raised rapidly, promotes sebaceous glands development
And produce a large amount of sebums.The dyskeratosis of pilosebaceous duct causes catheter blockage simultaneously, and dyssebacia forms cutin
Bolt is micro mist thorn.Multiple-microorganism especially propionibacterium acnes amount reproduction in hair follicle, the lipase that propionibacterium acnes is produced
Sebum generation free fatty is decomposed, while chemotactic inflammatory cell and medium, finally induce and aggravate inflammatory reaction.Thus may be used
See, propionibacterium acnes amount reproduction is a key factor for inducing whelk and causing whelk deterioration, therefore, it is right to study
The inhibitory action of propionibacterium acnes is one of important method of evaluation sample anti-acne action effect.
(1) test specimen：Inhibiting bacteria and diminishing inflammation composition, black extract of mulberry twig, hypericum perforatum flower extract in embodiment 1,
The composition of spearmint essential oil, hypericum perforatum flower extract and spearmint essential oil, 3 groups of (patients with acne of propionibacterium acnes bacterial strain
It is isolated at skin damaged)；
(2) test method：
1. culture, separation, the identification of anaerobic bacteria：THl0 cultures will be inoculated at patients with acne skin damaged by isolated sample
In base, airbag method is used, be placed in 37 DEG C of culture 72h in anaerobic jar, indicator is made with methylene blue, palladium grain is pierced for catalysis.
2. the separation of anaerobic bacteria
Picking single bacterium colony, turns 2 pieces of flat boards, and one piece is placed in anaerobic jar, the lower 37 DEG C of pure cultures of anaerobic condition；Another piece with
37 DEG C of aerobic cultures；Result is observed after 48h.
3. the identification of anaerobic bacteria
Without bacterial growth under aerobic culture；
Occur homogeneous form, canescence, tiny, diameter about 1.Omm raised circle, edge on the flat board of Anaerobic culturel slightly
Neat bacterium colony, microscopy is made by bacterium colony, visible chromabacterium biolaceum under mirror.It is micro-bend in bar-shaped or shaft-like, can one end blunt circle, one end attenuates,
Coloring is not deep, and cell is single, and it is the shapes such as " people ", " v " that can in pairs arrange or arrange.Again through oxytolerant experiment, catalase test, indoles
Experiment, biochemical series test for identification are propionibacterium acnes.
4. anaerobism drug sensitive test
Inoculation：1 colony inoculation in the bacterium colony more than picking cultivated on LB plating mediums, 37 DEG C of aerobic trainings
24h is supported, aerobic culture 24h propionibacterium acneses are rinsed with SPSS, flushing liquor is put into sterile test tube；Using wheat
Family name's turbidimetry need to shake 12 times than turbid before opacity tube, first than turbid to 3 × 108/mL, then with normal saline dilution to 106/mL
It is standby.
LB plating mediums are inoculated with：The swab stick of sterilizing is dipped into bacterium solution, unnecessary bacterium solution is gone in being squeezed on tube wall, in the training of LB flat boards
Even spread on base is supported, and a circle is swept along plate edge ring, cover plate, dry 2min.Aseptic steel bowl (a diameter of 6mm) is light
It is put on plating medium, fills it up with the inhibiting bacteria and diminishing inflammation composition of the gained of embodiment 1, be put into 37 DEG C of aerobic culture 24h, finds plate
It is interior without bacterial growth, see there is inhibition zone to be formed after continuing 37 DEG C of aerobic culture 24h.Antibacterial circle diameter is surveyed, by 3 groups of antibacterial circle diameters
Value is averaged.
Result of the test：It is experimental group with the inhibiting bacteria and diminishing inflammation composition group for adding the gained of embodiment 1, is taken with black extract of mulberry twig
It is control group 1 for the composition extract of embodiment 1, is right with the hypericum perforatum flower extract substitution composition extract of embodiment 1
It is control group 3 with the spearmint essential oil substitution composition extract of embodiment 1, with hypericum perforatum flower extract and spearmint according to group 2
Essential oil substitution embodiment 1 composition extract is control group 4.Chinese medicine antibacterial susceptibility grade classification, with reference to corresponding antibiotic mark
It is accurate ".Inhibition zone diameter>20mm is Gao Min, and 10~20mm is quick in being,<10mm is resistance, and specific observation result is as shown in Table 2.
Table two
Efficacy assessments：
Inhibiting bacteria and diminishing inflammation composition of the invention and black extract of mulberry twig, hypericum perforatum flower are can be seen that from above result of the test
The composition of extract, spearmint essential oil, hypericum perforatum flower extract and spearmint essential oil all has suppression propionibacterium acnes
Effect, and inhibiting bacteria and diminishing inflammation composition has quick effect (antibacterial circle diameter high to propionibacterium acnes>20mm)；Black ramulus mori is extracted
The composition of thing, hypericum perforatum flower extract, spearmint essential oil, hypericum perforatum flower extract and spearmint essential oil is to acne propionic acid
Bacillus quick effect (antibacterial circle diameter is between 10~20mm) in having, it can thus be seen that black mulberry in inhibiting bacteria and diminishing inflammation composition of the present invention
Branch extract, hypericum perforatum flower extract, spearmint essential oil have the effect of Synergistic.
Subjects：
300 26-35 Sui long the volunteer of whelk, and volunteer's facial area has papule, redness, skin greasing, pore
Thick, inflammatory reaction substantially, the warts symptom such as continuous repeatedly.
Selection standard:Glucocorticoid, dimension A classes medicine, antibiotic etc. are taken in clinical observation the last fortnight, and in the observation period
Between do not use said medicine；No drinking during observation, excessively pungent stimulation group food is not eaten.
550 people are randomly divided into 11 groups, every group of 50 people correspond to embodiment 1~5 respectively, and the comparative example 6 of comparative example 1~6 is certain
Commercially available anti-acne emulsion.Be evenly coated on the face the clean rear appropriate face cleaning dew that will be provided of Irrigation then sooner or later daily by patient
Clean up, continuing more than 30d must not be interrupted.
Criterion of therapeutical effect：
Criterion of therapeutical effect is worked out with reference to the guideline of clinical investigations of new Chinese medicine treatment acne vulgaris.1) it is almost recovered:It is scorching
Property fash all disappear, pigmentation is only stayed, without new fash；2) it is effective:Inflammatory deflorescence more than 70%, new fash is less than 5
It is individual；3) effectively:More than inflammatory deflorescence 30%-60%, new fash is less than 10；4) it is invalid:Inflammatory deflorescence is not enough
29% or without significant change, or even add severe one.
Clinical efficacy result is as shown in table 3 after 30d：
Table 3
By the average cure rate and effective efficiency of the visible embodiment 1~5 of table three for 37.2% and 98.8% far above contrast
The cure rate and effective percentage of example 1~5, it was demonstrated that the black extract of mulberry twig of anti-acne make-up composition of the present invention, hypericum perforatum flower extract,
Spearmint essential oil Synergistic on anti-acne effect.The cure rate of comparative example 6 and effective percentage are 30% and 84%, hence it is evident that less than implementation
Example 1~5, the present invention has remarkable result in terms of anti-acne.
Volunteer has no that obvious stimulation is reacted in process of the test, and 98% without pockmark residual, follow-up in the volunteer of recovery from illness
6 middle of the month, there are not relapse indications.
As can be seen from the above data, Chinese medicinal anti-acne composition of the invention is non-stimulated to skin safe, and it is used as work(
Can not only play a part of anti-acne in property additive addition cosmetics series, pockmark be repaired, while curative effect stabilization, can prevent
Whelk recurrent exerbation.
Above example only illustrates embodiment of the present invention, does not there is any formal limitation to the present invention；Appoint
What is engaged in professional and technical personnel, all has the ability to make some changes using the technology contents for disclosing or modifies, as equivalent
The Equivalent embodiments of change, according to the technology of the present invention essence, simply modification, equivalent variations and modification are carried out to the present invention, are belonged to
In the range of technical solution of the present invention.
Claims (10)
1. a kind of inhibiting bacteria and diminishing inflammation composition, it is characterised in that the inhibiting bacteria and diminishing inflammation composition is consisted of the following composition：Hypericum perforatum
Flower extract, black extract of mulberry twig, spearmint essential oil.
2. a kind of inhibiting bacteria and diminishing inflammation composition according to claim 1, it is characterised in that the inhibiting bacteria and diminishing inflammation composition it is each into
The weight part ratio for dividing is (1-10)：(2-10)：(0.1-1).
3. a kind of inhibiting bacteria and diminishing inflammation composition according to claim 1, it is characterised in that the inhibiting bacteria and diminishing inflammation composition it is each into
Point weight portion be：
0.1-1 parts of hypericum perforatum flower extract
Black extract of mulberry twig 0.2-0.8 parts
Spearmint essential oil 0.01-0.08 parts.
4. a kind of inhibiting bacteria and diminishing inflammation composition according to claim 1, it is characterised in that the hypericum perforatum flower extract
Preparation method is as follows：Hypericum perforatum flower petal is taken, with 75-90% ethanol solutions refluxing extraction 2-3 time, merges extract solution, depressurized
Concentration, 8000-9000r/min centrifugations, takes supernatant；Supernatant is injected into large pore resin absorption column, 20-50% ethanol elutions are used
Impurity, then 60-85% ethanol elutions are used, eluent is reclaimed, spray drying is obtained dry extract, i.e., described hypericum perforatum flower is carried
Take thing.
5. a kind of inhibiting bacteria and diminishing inflammation composition according to claim 1, it is characterised in that the preparation of the black extract of mulberry twig
Method is：Black ramulus mori is extracted 2-3 times with the ethanol solution of 75-90% at a temperature of 70-100 DEG C, merges extract solution；Will be upper
Extract solution regulation pH to 7-9 is stated, 1-2h is stood, 7000-9000r/min centrifugations take supernatant, adjust pH to 4-6, gone after standing
Sediment, washing and drying obtains the black extract of mulberry twig.
6. bacteria inhibiting composition as claimed in claim 1 is in preparing with inhibiting bacteria and diminishing inflammation, the cosmetics of anti-ageing repair function
Using.
7. application according to claim 6, it is characterised in that the cosmetics are face cream.
8. a kind of inhibiting bacteria and diminishing inflammation face cream, it is characterised in that the face cream includes the composition of following weight portion：
Emulsifying agent：3.5-6.3 parts
Emollient：5-10 parts
Antioxidant：0.2-0.8 parts
NMF：5-15 parts
Thickener：0.05-0.15 parts
Preservative：0.3-0.7 parts
Inhibiting bacteria and diminishing inflammation composition as described in claim any one of 1-5：0.31-1.88 parts
Deionized water is to 100 parts.
9. a kind of inhibiting bacteria and diminishing inflammation face cream according to claim 8, it is characterised in that the emulsifying agent be cetostearyl alcohol/
Cetearyl glucoside, cetostearyl alcohol, stearine/PEG-100 stearates；
The emollient is dimethyl silicone polymer, caprylic/capric triglyceride, hydrogenated jojoba oil；
The antioxidant is tocopherol, is confused the extract that changes；
The NMF is propane diols, glycerine, Sodium Hyaluronate, sorbierite；
The thickener is sodium carboxymethylcellulose；
The preservative is Phenoxyethanol, Sodium Benzoate.
10. a kind of method for preparing the face cream as described in claim 8 or 9, it is characterised in that the described method comprises the following steps：
75-85 DEG C is heated to during emollient, emulsifying agent are added into oil phase pot, stirring is complete, is incubated stand-by as A phases；By NMF, increase
Thick dose, deionized water is added in water phase pot, be heated to 75-85 DEG C of stirring be incubated completely it is stand-by as B phases；Emulsification pot is preheated to
, first be pumped into for B phases by 60-65 degree, 45 revs/min of mixing speed, then A phases are pumped into, and is stirred 30 minutes, and temperature is maintained at 85 degree；
Homogeneous 3 minutes；Inhibiting bacteria and diminishing inflammation composition, antioxidant, preservative are added after being cooled to 35-45 DEG C, insulated and stirred is equal to mixing
It is even, 35 revs/min of mixing speed；Vacuumize discharging.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112741777A (en) * | 2020-12-29 | 2021-05-04 | 山东爱维德生物科技有限公司 | A method for preparing Aloe arborescens extract-spearmint essential oil-chitosan-sodium alginate gel for infants |
| CN115006329A (en) * | 2022-06-30 | 2022-09-06 | 山东博科医用材料有限公司 | Oil-control moisture-retention pure water |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1452979A (en) * | 2003-05-17 | 2003-11-05 | 广西化工生物技术研究所 | Medicine composition with anti-inflammatory effect and its production process |
| CN102283259A (en) * | 2010-10-28 | 2011-12-21 | 李俊卿 | Lymphocyte T (LYT) antibacterial and antiviral plant active new material |
| CN103202796A (en) * | 2013-04-15 | 2013-07-17 | 北京华夏众芳生物科技有限公司 | Skin care composition and face cream with acne treatment efficacy and preparation method of face cream |
| CN103976916A (en) * | 2014-05-30 | 2014-08-13 | 广州丹奇日用化工厂有限公司 | Berberis julianae schneid extracting solution and preparation method and application thereof |
| CN104055708A (en) * | 2014-07-07 | 2014-09-24 | 广州丹奇日用化工厂有限公司 | Anti-inflammatory cosmetic composition and preparation method thereof |
-
2016
- 2016-12-28 CN CN201611240871.6A patent/CN106726987A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1452979A (en) * | 2003-05-17 | 2003-11-05 | 广西化工生物技术研究所 | Medicine composition with anti-inflammatory effect and its production process |
| CN102283259A (en) * | 2010-10-28 | 2011-12-21 | 李俊卿 | Lymphocyte T (LYT) antibacterial and antiviral plant active new material |
| CN103202796A (en) * | 2013-04-15 | 2013-07-17 | 北京华夏众芳生物科技有限公司 | Skin care composition and face cream with acne treatment efficacy and preparation method of face cream |
| CN103976916A (en) * | 2014-05-30 | 2014-08-13 | 广州丹奇日用化工厂有限公司 | Berberis julianae schneid extracting solution and preparation method and application thereof |
| CN104055708A (en) * | 2014-07-07 | 2014-09-24 | 广州丹奇日用化工厂有限公司 | Anti-inflammatory cosmetic composition and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王建新: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112741777A (en) * | 2020-12-29 | 2021-05-04 | 山东爱维德生物科技有限公司 | A method for preparing Aloe arborescens extract-spearmint essential oil-chitosan-sodium alginate gel for infants |
| CN112741777B (en) * | 2020-12-29 | 2023-06-02 | 山东爱维德生物科技有限公司 | Preparation method of aloe arborescens extract-spearmint essential oil-chitosan-sodium alginate gel suitable for infants |
| CN115006329A (en) * | 2022-06-30 | 2022-09-06 | 山东博科医用材料有限公司 | Oil-control moisture-retention pure water |
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