CN106699810A - 一种含氮杂环化合物及其制备方法与在抑制激酶活性中的应用 - Google Patents
一种含氮杂环化合物及其制备方法与在抑制激酶活性中的应用 Download PDFInfo
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- CN106699810A CN106699810A CN201611021938.7A CN201611021938A CN106699810A CN 106699810 A CN106699810 A CN 106699810A CN 201611021938 A CN201611021938 A CN 201611021938A CN 106699810 A CN106699810 A CN 106699810A
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- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims description 5
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 5
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- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical class ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 claims description 4
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims description 4
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- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 4
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- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 4
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- RQBJDYBQTYEVEG-UHFFFAOYSA-N benzylphosphane Chemical group PCC1=CC=CC=C1 RQBJDYBQTYEVEG-UHFFFAOYSA-N 0.000 claims description 4
- XJHCXCQVJFPJIK-UHFFFAOYSA-M caesium fluoride Chemical compound [F-].[Cs+] XJHCXCQVJFPJIK-UHFFFAOYSA-M 0.000 claims description 4
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- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 4
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims description 4
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 claims description 4
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- MFRIHAYPQRLWNB-UHFFFAOYSA-N sodium tert-butoxide Chemical compound [Na+].CC(C)(C)[O-] MFRIHAYPQRLWNB-UHFFFAOYSA-N 0.000 claims description 4
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- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 2
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- GCUVBACNBHGZRS-UHFFFAOYSA-N cyclopenta-1,3-diene cyclopenta-2,4-dien-1-yl(diphenyl)phosphane iron(2+) Chemical compound [Fe++].c1cc[cH-]c1.c1cc[c-](c1)P(c1ccccc1)c1ccccc1 GCUVBACNBHGZRS-UHFFFAOYSA-N 0.000 claims description 2
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- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- 229950004288 tosilate Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- IAQRGUVFOMOMEM-ONEGZZNKSA-N trans-but-2-ene Chemical compound C\C=C\C IAQRGUVFOMOMEM-ONEGZZNKSA-N 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 150000004684 trihydrates Chemical class 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- IHIXIJGXTJIKRB-UHFFFAOYSA-N trisodium vanadate Chemical compound [Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O IHIXIJGXTJIKRB-UHFFFAOYSA-N 0.000 description 1
- XPFJYKARVSSRHE-UHFFFAOYSA-K trisodium;2-hydroxypropane-1,2,3-tricarboxylate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical class [Na+].[Na+].[Na+].OC(=O)CC(O)(C(O)=O)CC(O)=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O XPFJYKARVSSRHE-UHFFFAOYSA-K 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 229960004418 trolamine Drugs 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 229940075466 undecylenate Drugs 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2015107888386 | 2015-11-17 | ||
| CN201510788838 | 2015-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106699810A true CN106699810A (zh) | 2017-05-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611021938.7A Pending CN106699810A (zh) | 2015-11-17 | 2016-11-16 | 一种含氮杂环化合物及其制备方法与在抑制激酶活性中的应用 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN106699810A (fr) |
| WO (1) | WO2017084640A1 (fr) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019015655A1 (fr) * | 2017-07-19 | 2019-01-24 | 正大天晴药业集团股份有限公司 | Composé aryl-phosphore-oxygène utilisé en tant qu'inhibiteur de kinase egfr |
| CN109369721A (zh) * | 2017-12-21 | 2019-02-22 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制激酶活性的芳基磷氧化物 |
| WO2020147838A1 (fr) * | 2019-01-18 | 2020-07-23 | 正大天晴药业集团股份有限公司 | Sel d'un inhibiteur d'egfr, forme cristalline et procédé de préparation associé |
| WO2020216371A1 (fr) * | 2019-04-26 | 2020-10-29 | 江苏先声药业有限公司 | Inhibiteur d'egfr et son utilisation |
| CN112824420A (zh) * | 2019-11-21 | 2021-05-21 | 浙江同源康医药股份有限公司 | 用作egfr激酶抑制剂的化合物及其应用 |
| CN113527281A (zh) * | 2020-04-20 | 2021-10-22 | 昆山彭济凯丰生物科技有限公司 | 杂环化合物及其制备方法和应用 |
| WO2022199589A1 (fr) * | 2021-03-23 | 2022-09-29 | 南京明德新药研发有限公司 | Dérivés de pyrimidine |
| WO2022253081A1 (fr) * | 2021-06-03 | 2022-12-08 | 希格生科（深圳）有限公司 | Dérivé d'oxyde de phosphine, son procédé de préparation et son application |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220259235A1 (en) * | 2019-07-26 | 2022-08-18 | Betta Pharmaceuticals Co., Ltd | EGFR Inhibitor, Composition, and Preparation Method Therefor |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009143389A1 (fr) * | 2008-05-21 | 2009-11-26 | Ariad Pharmaceuticals, Inc. | Dérivés phosphorés servant d'inhibiteurs de kinase |
| CN103153064A (zh) * | 2010-10-14 | 2013-06-12 | 阿里亚德医药股份有限公司 | 抑制egfr导致的癌症中细胞增殖的方法 |
| WO2014071832A1 (fr) * | 2012-11-06 | 2014-05-15 | Shanghai Fochon Pharmaceutical Co Ltd | Inhibiteurs de kinase alk |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030004174A9 (en) * | 2000-02-17 | 2003-01-02 | Armistead David M. | Kinase inhibitors |
| WO2009126515A1 (fr) * | 2008-04-07 | 2009-10-15 | Irm Llc | Composés et compositions comme inhibiteurs de la protéine kinase |
-
2016
- 2016-11-16 CN CN201611021938.7A patent/CN106699810A/zh active Pending
-
2017
- 2017-01-06 WO PCT/CN2017/070372 patent/WO2017084640A1/fr active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009143389A1 (fr) * | 2008-05-21 | 2009-11-26 | Ariad Pharmaceuticals, Inc. | Dérivés phosphorés servant d'inhibiteurs de kinase |
| CN102105150A (zh) * | 2008-05-21 | 2011-06-22 | 阿里亚德医药股份有限公司 | 用作激酶抑制剂的磷衍生物 |
| CN103153064A (zh) * | 2010-10-14 | 2013-06-12 | 阿里亚德医药股份有限公司 | 抑制egfr导致的癌症中细胞增殖的方法 |
| WO2014071832A1 (fr) * | 2012-11-06 | 2014-05-15 | Shanghai Fochon Pharmaceutical Co Ltd | Inhibiteurs de kinase alk |
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113354685A (zh) * | 2017-07-19 | 2021-09-07 | 正大天晴药业集团股份有限公司 | 作为egfr激酶抑制剂的芳基磷氧化合物 |
| KR20200032146A (ko) * | 2017-07-19 | 2020-03-25 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | Egfr 키나제 억제제로써의 아릴-인-산소 화합물 |
| CN110944989A (zh) * | 2017-07-19 | 2020-03-31 | 正大天晴药业集团股份有限公司 | 作为egfr激酶抑制剂的芳基磷氧化合物 |
| WO2019015655A1 (fr) * | 2017-07-19 | 2019-01-24 | 正大天晴药业集团股份有限公司 | Composé aryl-phosphore-oxygène utilisé en tant qu'inhibiteur de kinase egfr |
| KR102647277B1 (ko) | 2017-07-19 | 2024-03-12 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | Egfr 키나제 억제제로써의 아릴-인-산소 화합물 |
| CN113354685B (zh) * | 2017-07-19 | 2022-12-20 | 正大天晴药业集团股份有限公司 | 作为egfr激酶抑制剂的芳基磷氧化合物 |
| CN110944989B (zh) * | 2017-07-19 | 2021-06-25 | 正大天晴药业集团股份有限公司 | 作为egfr激酶抑制剂的芳基磷氧化合物 |
| US11390625B2 (en) | 2017-07-19 | 2022-07-19 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Aryl-phosphorus-oxygen compound as EGFR kinase inhibitor |
| CN109369721A (zh) * | 2017-12-21 | 2019-02-22 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制激酶活性的芳基磷氧化物 |
| WO2019120094A1 (fr) * | 2017-12-21 | 2019-06-27 | 深圳市塔吉瑞生物医药有限公司 | Oxydes d'arylphosphine agissant en tant qu'inhibiteurs de l'activité kinase |
| CN109369721B (zh) * | 2017-12-21 | 2024-05-14 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制激酶活性的芳基磷氧化物 |
| WO2020147838A1 (fr) * | 2019-01-18 | 2020-07-23 | 正大天晴药业集团股份有限公司 | Sel d'un inhibiteur d'egfr, forme cristalline et procédé de préparation associé |
| CN113260613A (zh) * | 2019-01-18 | 2021-08-13 | 正大天晴药业集团股份有限公司 | 一种egfr抑制剂的盐、晶型及其制备方法 |
| CN113260613B (zh) * | 2019-01-18 | 2022-12-30 | 正大天晴药业集团股份有限公司 | 一种egfr抑制剂的盐、晶型及其制备方法 |
| CN113166103A (zh) * | 2019-04-26 | 2021-07-23 | 江苏先声药业有限公司 | Egfr抑制剂及其应用 |
| WO2020216371A1 (fr) * | 2019-04-26 | 2020-10-29 | 江苏先声药业有限公司 | Inhibiteur d'egfr et son utilisation |
| CN112824420B (zh) * | 2019-11-21 | 2022-04-26 | 浙江同源康医药股份有限公司 | 用作egfr激酶抑制剂的化合物及其应用 |
| WO2021098883A1 (fr) * | 2019-11-21 | 2021-05-27 | 浙江同源康医药股份有限公司 | Composé utilisé en tant qu'inhibiteur de kinase egfr et son utilisation |
| CN112824420A (zh) * | 2019-11-21 | 2021-05-21 | 浙江同源康医药股份有限公司 | 用作egfr激酶抑制剂的化合物及其应用 |
| CN113527281A (zh) * | 2020-04-20 | 2021-10-22 | 昆山彭济凯丰生物科技有限公司 | 杂环化合物及其制备方法和应用 |
| CN113527281B (zh) * | 2020-04-20 | 2023-12-22 | 昆山彭济凯丰生物科技有限公司 | 杂环化合物及其制备方法和应用 |
| WO2022199589A1 (fr) * | 2021-03-23 | 2022-09-29 | 南京明德新药研发有限公司 | Dérivés de pyrimidine |
| WO2022253081A1 (fr) * | 2021-06-03 | 2022-12-08 | 希格生科（深圳）有限公司 | Dérivé d'oxyde de phosphine, son procédé de préparation et son application |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017084640A1 (fr) | 2017-05-26 |
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