CN106693295A - Swallowing training pen capable of achieving segmented dosing and application of training pen in treating radiation-induced oral mucositis - Google Patents
Swallowing training pen capable of achieving segmented dosing and application of training pen in treating radiation-induced oral mucositis Download PDFInfo
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- A—HUMAN NECESSITIES
- A63—SPORTS; GAMES; AMUSEMENTS
- A63B—APPARATUS FOR PHYSICAL TRAINING, GYMNASTICS, SWIMMING, CLIMBING, OR FENCING; BALL GAMES; TRAINING EQUIPMENT
- A63B23/00—Exercising apparatus specially adapted for particular parts of the body
- A63B23/025—Exercising apparatus specially adapted for particular parts of the body for the head or the neck
- A63B23/03—Exercising apparatus specially adapted for particular parts of the body for the head or the neck for face muscles
- A63B23/032—Exercising apparatus specially adapted for particular parts of the body for the head or the neck for face muscles for insertion in the mouth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
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- A61M2210/0625—Mouth
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Abstract
The invention provides a swallowing training pen capable of achieving segmented dosing and application of the training pen in treating radiation-induced oral mucositis. The training pen comprises a pen holder with the inner part provided with drug cores, a core containing cavity in the pen holder can contain at least two drug cores which are sequentially arranged in the core containing cavity. The rear end of the pen holder is provided with a pushing part which is used for sequentially pushing drugs on the drug cores to a drug outlet of the training pen. The front end of the pen holder is provided with a clamping part so as to ensure that the drugs are not separated from the pen holder in the taking process of a patient. The drugs on the training pen can be pulled out from an oral cavity in real time, and the requirement for dosing the patient suffering from the radiation-induced oral mucositis in a segmented mode can be met. The swallowing training pen integrating various swallowing training tools, so that swallowing training is more convenient.
Description
Technical field
The present invention relates to a kind of administration apparatus, specifically a kind of swallowing training pen for being segmented administration and in therapeutic radiation mouthful
Application in the mucositis of chamber.
Background technology
Nasopharyngeal carcinoma is one of clinically relatively common malignant tumour, accounts for more than the 70% of head and neck neoplasm.Radiotherapy
It is the main method for treating nasopharyngeal carcinoma, definite effect.Most common during nasopharyngeal carcinoma radiotherapy is also the secondary anti-of main appearance
Should --- ulcer caused by radioactivity portacaval mucositis and pain directly affects the degree and intensity of Open mouth training, and radioactive ray are held
Nutritional deficiency caused by continuous effect and eating difficulties, have impact on Mucous rehabilitation, and slowness healing belt comes proliferation of fibrous tissue, scar
Trace is formed, so as to finally cause difficulty in opening mouth to occur.
Easily cause aphetite disorder after generation radiotherapy-induced oral mucositis, the maximum danger of aphetite disorder is to miss
Inhale.There is a document report, the food of various trait mixes, it is necessary to masticatory ability higher, and be difficult to form cohesive force strong
Food group, when swallowing part food easily fall into too early it is pharyngeal, into air flue.Therefore, the still undesirable patient of function of deglutition should
It is when avoiding that the different food of proterties is mixed in together.Such as the food that liquid and solid mix.Swallowed after nasopharyngeal carcinoma radiotherapy
The proterties that disorder patients suitably adjust food can efficiently reduce the generation inhaled by mistake, be a kind of economic, practical, safe method.
What most of patients with deglutition disorders was easiest to suction by mistake is dilute liquid, will add thickener to increase viscosity in thin liquid, can reduce mistake
Inhale.Prior art is that the medicine for the treatment of of acute radiation oral mucositis is made into ice cube, but the aqueous pharmaceutical after ice is melted is easy
Into it is pharyngeal cause by mistake inhale generation can choke patient, there is unsafe factor.
In addition to nasopharyngeal carcinoma radiotherapy, brain stem lesions, brain trauma, tongue cancer is postoperative etc., and disease also often results in tongue muscle strength not
Foot, tonguing is uncoordinated when swallowing waits dysphagia.Clinically serious oro-tracheal sensation is normal dyskinesia
There is lip closure obstacle, obstacle of dehiscing, tongue swallows start delay towards the dyskinesia of all directions, and liquid is in swallowing act
It is preceding flow into it is pharyngeal wait Novel presentation, be easily caused before swallowing and inhale by mistake, cause pulmonary infection repeatedly and it is malnutritive, be dehydrated, support
The problems such as drag is reduced, severe patient can also cause death.
It is to improve one of clinical method of dysphagia at present using oral sensation training technology, the method can
Sensation and muscle function treatment suitable for mouth face, help improve the sensation i.e. motor function of oral cavity organs.Therefore oral cavity sense
Feel that training is extremely important, this technology includes that tongue presses resistance feedback training, K points stimulation, vibrating head to enter the oral cavity of patient
Row vibratory stimulation, method simple practical can help patient to recover oral sensation.
Often the training of tongue pressure is carried out using tongue depressor and lip is trained.Spatula is for example put in the tongue middle part of patient, trouble is advised
Person's lift tongue is exerted oneself upper to hard palate.When lip is trained, advise patient to clamp spatula with lip, adhere to 5 seconds, loosen, be repeated several times
K points are located at the height of retromolar triangle, and dehiscing and swallowing startup for patient can be induced by stimulating this position.Gulp down
When swallowing the treatment of obstacle, stimulate K points that patient can be helped to be open, be that mouthful face training and MC create good conditions.Stimulate K
Point has various methods, and one is that finger stimulates K points.Two is that, for the patient of serious difficulty in opening mouth, can use island spoon (K spoonfuls) directly
Stimulate K points.
There is mouth face sensorimotor obstacle in patient, and the sensation vibratory stimulation in oral cavity can be made of vibrating head, promotes oral cavity
The recovery of sensation.When using, the head of vibrating head is placed on oral cavity needs stimulation location, power-on to vibrate, slidably vibrating head
Head vibration needs the position for stimulating, until the organ generation action being stimulated or sensation.
Either tongue depressor, K spoonful or vibrating head are all each independent assistive devices, and patient is doing oral sensation campaign
Need to prepare many set instruments during training.Ulcer and pain caused by this kind of patient simultaneously adjoint this portacaval mucositis, therefore often
First allow patient oral with anesthesiophore medicine, pain when being trained with reduction of patient before training.It is this at present to carry
The medicine of anesthetic effect is often administered in the form of ice cube, but the aqueous pharmaceutical after ice is melted is easily accessible and pharyngeal causes to inhale hair by mistake
Give birth to and choke patient.Therefore, no matter the apparatus preparation before mouth motion training, or instrumentation and trouble in training process
Person misses the observation of the adverse reactions such as suction, is all cumbersome.Therefore the efficiency for how improving existing oral sensation training is to gulp down
Pharynx rehabilitation training subject has always a demand for the problem for solving.
The content of the invention
It is an object of the invention to provide it is a kind of be segmented administration swallowing training pen, including internal charge core penholder, penholder
It is interior deposit core cavity and can at least accommodate two medicine cores be arranged in order in it, the rear end of penholder is provided with push part, by the medicine in medicine core
Product push to medicine exit successively, and penholder front end is provided with clamping part, to keep medicine that pen is not departed from during being used by clothes for patients
Bar.
Further, the push part is piston type push structure or spring structure.
Further, the clamping part is selected from block piece, on the projection and penholder on the fastener with card base, or medicine support
Projection bayonet socket.
Further, the medicine support is hollow-core construction.
Further, the front portion of the medicine support is equipped with functional bar, and functional bar is for platypelloid type and front end is provided with projection.
Further, a vibrator is mounted with the outer wall of the penholder.
Further, described also to include the cap for brush, the leading portion connection of the cap for brush may be folded in the stock on the cap for brush, the cap for brush and stock
Between by rotating shaft connect.
Further, the front end of the stock is provided with projection.
Further, the medicine is Compound Glycyrrhiza, is formed using multi-medicament mixing match, and contained drug includes
Liquorice liquid 175-350ml, than sub- sweet smell 2.5-7.5g, gentamicin 40-120 ten thousand unit, lidocaine 0.05-0.15g is appropriate to grow
The moon moisturizes the auxiliary material and solid agent for promoting the production of body fluid.
Present invention also offers swallowing training pen the facing on treatment of acute radiation oral mucositis of segmented administration
Bed application.
Training pen of the present invention can meet the requirement of patients with radioactive mucositis of oral cavity patient's divided doses, and can be by
Various swallowing training Tool integrations are integrated, and make swallowing training more convenient.
Brief description of the drawings
The swallowing training internal structure schematic diagram of Fig. 1 the first segmented administrations.
The structural representation that pen point casing in the swallowing training pen of Fig. 2 first item segmented administration with penholder separate.
The external structure schematic diagram of the swallowing training pen of Fig. 3 second item segmented administration.
The generalized section in Fig. 4 Fig. 3 A-A directions.
The explosive view of Fig. 5 second item swallowing training pen.
The external structure schematic diagram of the swallowing training pen of Fig. 6 third item segmented administration.
The generalized section in Fig. 7 Fig. 6 B-B directions.
Fig. 8 fastener gripping orientation schematic diagrames.
Fig. 9 fastener releasing orientation schematic diagrames.
Figure 10 medicine cores go out to depart from schematic diagram from the fastener for unclamping.
The internal structure schematic diagram of the swallowing training pen of Figure 11 fourth item segmented administration.
Figure 12 hollow medicine holder structure schematic diagram.
Figure 13 hollow medicine support side schematic view.
Figure 14 is mounted with the hollow medicine support schematic diagram of medicine.
It is mounted with that the swallowing training of vibrator compares schematic diagram on Figure 15 penholders.
Cap for brush schematic diagrames of the Figure 16 with stock.
Specific embodiment
As shown in Fig. 1 to 11 segmented administration swallowing training pen, including internal charge core penholder 1, in penholder
Deposit core cavity 11 and can at least accommodate two medicine cores 2 and be arranged in order in it, the medicine in medicine core stretches out from medicine exit 12.Penholder
Rear end be provided with push part, the medicine in medicine core is pushed into medicine exit successively.Penholder front end is provided with clamping part, to keep medicine
Product do not depart from penholder during being used by clothes for patients.
Swallowing training pen as shown in Fig. 1 to 2, including with the penholder 1 of core cavity 11 is deposited, medicine core 2 includes medicine support 21 and connects
It is connected on the medicine 22 in medicine support.Push part is piston type push structure, including push rod 31 and piston 32, piston 32 are interior with penholder
Wall is fitted close, and is resisted against in medicine support.The front end of penholder is provided with pen point casing 4, and pen point casing is socketed with modes such as screw thread or buckles
On penholder.The opening of pen point casing is medicine exit 12, and the block piece 41 at opening is clamping part.When medicine stretches out outlet 12
Afterwards, the convex portion 211 in medicine support stops that, so as to avoid patient when medicine is taken, whole medicine core is left by the block piece of pen point casing
Penholder.After medicine has been taken, written cap of outwarding winding takes out used medicine core, then recovers on penholder pen point casing.When will
During using medicine in second medicine core, push rod is promoted, then piston promotes untapped medicine core to move forward, until medicine is stretched
Go out medicine exit.
Swallowing training pen as shown in Fig. 3 to 5, including with the penholder 1 of core cavity 11 is deposited, medicine core 2 includes medicine support 21 and connects
It is connected on the medicine 22 in medicine support.The front end of penholder is provided with pen point casing 4, and pen point casing is socketed in penholder with modes such as screw thread or buckles
On.The opening of pen point casing is medicine exit, and the block piece 41 at opening is clamping part, and block piece plays the convex portion stopped in medicine support
211 effect.The rear end of penholder is provided with cap 13.After medicine has been taken, written cap of outwarding winding takes out used medicine core, so
Pen point casing is recovered on penholder afterwards.When to use new medicine core, rise and write for the first time lid 13, new medicine core is loaded from the rear end of penholder,
Then cap is covered, cap coordinates with the new medicine core for loading, and promotes original medicine core to move forward, until medicine stretches out medicine and goes out
Mouthful.Push part in this embodiment includes cap and the rear medicine core for loading.
Swallowing training pen as shown in Fig. 6 to 10, including with the penholder 1 of core cavity is deposited, medicine core includes medicine support 21 and connection
Medicine 22 in medicine support.Push part is spring assembly, including spring 33, and the two ends of spring respectively connected push jack 34 and spring
Fixture 35, push jack 34 is contacted with medicine support.Spring is in compressive state, after the medicine core taken is taken out, using the bullet of spring
Push remaining medicine core in bar of starting writing previously to move, until medicine stretches out medicine exit.Clamping part is fastener 5, and fastener includes card
Pin 51.As shown in figure 8, card base tightly opens medicine core；As shown in figure 9, card base is broken to both sides, so as to unclamp medicine core；Such as
Shown in Figure 10, the used medicine core of food is taken out, and latter medicine core is therewith with going out to medicine exit；Discard old medicine core, new medicine
Core is by rechuck at medicine exit.
Swallowing training pen as shown in figure 11, including with the penholder 1 of core cavity 11 is deposited, medicine core 2 includes medicine support 21 and connection
Medicine 22 in medicine support.Push part is spring assembly, including spring 33, and the two ends of spring respectively connected push jack 34 and spring
Fixture 35, push jack 34 is contacted with medicine support.Spring is in compressive state, after the medicine core taken is taken out, using the bullet of spring
Push remaining medicine core in bar of starting writing previously to move, until medicine stretches out medicine exit.Clamping part includes the bullet on medicine support outer wall
Projection bayonet socket 7 on property projection 6 and penholder.The stopper slot 14 for elastic projection movement, stopper slot are additionally provided with penholder inwall
Extend at projection bayonet socket.The elastic projection of medicine core is inserted into stopper slot 14, medicine core is sequentially loaded into medicine-storing cavity along stopper slot
It is interior.When the projection 6 of medicine core is moved at bayonet socket 7, the projection that is compressed is inserted into bayonet socket after resetting, so as to by medicine foremost
Core clamping.After medicine use, in bayonet socket projection apply a power, allow it to be compressed again so as to depart from bayonet socket, not by
The medicine core of clamping can be taken out from penholder, and latter medicine core, by the pressure of spring, projection is moved at bayonet socket, new medicine
Core is clamped.
Medicine support in medicine core can be solid construction, or the hollow knot as shown in Fig. 6 or 12 as shown in Figure 1
Structure.When medicine core is sequentially placed into penholder, the medicine in latter medicine core can enter the medicine support cavity 212 of previous medicine core
Interior, such combination can save emission quotas of the medicine core in penholder, reduce the length of penholder.
Medicine support as shown in Figure 12 to 14, functional bar 213 is equipped with the front portion of medicine support.Functional bar is that platypelloid type and front end set
Have raised 214, after sticking to the medicine on functional bar and having taken, the projection will be exposed, the projection can be used to pierce
Swash the K points of tooth.Or the functional bar of platypelloid type is used as spatula.
In scheme as shown in figure 15, a vibrator 16 is mounted with the outer wall of penholder 1.Open vibrator, pen
Bar also vibrates therewith.
Swallowing training pen also includes the cap for brush 15.Such as Figure 16, the leading portion connection of the cap for brush may be folded in the stock 151 on the cap for brush,
Connected by rotating shaft 152 between the cap for brush and stock, the front end of stock is provided with raised 214.The projection can be used to stimulate the K of tooth
Point.Or stock can also be used as spatula.
Medicine on the swallowing training pen is Compound Glycyrrhiza, is formed using multi-medicament mixing match, institute's pastille
Thing includes liquorice liquid 175-350ml, than sub- sweet smell 2.5-7.5g, gentamicin 40-120 ten thousand unit, lidocaine 0.05-0.15g,
Auxiliary material and solid agent that appropriate nourshing Yin and drynsessmoistening prescription is promoted the production of body fluid.
In a specific embodiment, contained drug includes liquorice liquid 250ml, and than sub- sweet smell 5g, gentamicin 800,000 is single
Position, lidocaine 0.1g, auxiliary material and solid agent that appropriate nourshing Yin and drynsessmoistening prescription is promoted the production of body fluid.
The following is the effect of effect and auxiliary material of each main component in the Compound Glycyrrhiza：
Radix Glycyrrhizae：The root and rhizome of glycyrrhizic legume, modern medicine study proves that Radix Glycyrrhizae contains various active composition, has
Antiviral, antiulcer, analgesic, regulation be immune and the multiple efficacies such as endocrine, and licorice can effectively suppress golden yellow grape
The such as coccus, hay bacillus, clostridium, Pseudomonas aerogenic bacteria have strength antibacterial action.
It is more fragrant than sub-：With deep aquation, moisturizing moisturizing；VPV can be increased, improve microcirculation, help is discharged and oozed
Go out thing, reduce inflammation；Improve histanoxia, mitigate pain；1L-6 generations can be also reduced, to suppressing the meat fiber that radiotherapy causes
Change has positive effect, than it is sub- fragrant have moisturizing, prevent fibrosis, analgesic, promote exclusion exudate, the work(such as reduce inflammation
Effect.
Lidocaine：Local anaesthetics is imitated in a kind of amide-type, with rapid-action, disperse is wide, the features such as penetrability is strong, during containing changing
Mucous membrane tip is felt paralysis, and cause analgesic activity, cold therapy can reduce the reduction of oral cavity partial CBF, limit inflammation
Diffusion, mucous membrane of mouth activity is suppressed, reduces nerve ending sensitivity.
The auxiliary material that nourshing Yin and drynsessmoistening prescription is promoted the production of body fluid：Suitably increase the food that some nourshing Yin and drynsessmoistening prescription are promoted the production of body fluid, such as sugar-cane juice, pear juice, water chestnut
Juice, watermelon juice, lotus root juice, strawberry juice, orange juice etc., there is the nourshing Yin and drynsessmoistening prescription effect of promoting the production of body fluid, and reduce dry, the amount of ptyalizing, promote
Taste dysfunction recovers.
Solid agent：The solid agent is pectin, also including carrying toner caramel, also including sweetener, and such as corn syrup, honeybee
Honey, white sugar or xylitol etc..
Can be prepared one of by the following method as the Compound Glycyrrhiza of medicine.
Preparation method 1, it is specific as follows：
(1) small fire decocts 10min after selection licorice 10-30g, plus 250-750ml bubbles 30min, and filtered juice removes slag, natural
It is standby into about 125-375ml after cooling.125-375ml liquorice liquids are taken, is added than sub- sweet smell 2.5-7.5g, gentamicin 40-120 ten thousand
Unit, lidocaine 0.05-0.15g, sugar-cane juice 10-30g, pectin 20-60g, caramel 5-15g and corn syrup 10-30g are formed
Mixture；
(2) mixture that will be obtained in step (1), pours into lollipop mould and is pressed into that 0.5cm is thick, ellipse 2cm wide
Shape sugar structure, and plunger carries out condensation drying；
(3) a kind of glycyrrhiza compound lollipop for the treatment of of acute radiation oral mucositis is made after drying to be condensed terminates.
Preparation method 2, it is specific as follows：
(1) small fire decocts 10min after selection licorice 10-30g, plus 250-750ml bubbles 30min, and filtered juice removes slag, natural
It is standby into about 125-375ml after cooling.125-375ml liquorice liquids are taken, is added than sub- sweet smell 2.5-7.5g, gentamicin 40-120 ten thousand
Unit, lidocaine 0.05-0.15g, water chestnut juice 10-30g, pectin 20-60g, caramel 5-15g and xylitol 10-30g form mixed
Compound；
(2) mixture that will be obtained in step (1), pours into lollipop mould and is pressed into that 0.5cm is thick, ellipse 2cm wide
Shape sugar structure, and plunger carries out condensation drying；
(3) a kind of glycyrrhiza compound lollipop for the treatment of of acute radiation oral mucositis is made after drying to be condensed terminates.
The preparation method is used from few sugar formula, suitable diabetic.
Preparation method 3, it is specific as follows：
(1) small fire decocts 10min after selection licorice 10g, plus 250ml bubbles 30min, and filtered juice removes slag, after natural cooling
It is standby into about 125ml.125ml liquorice liquids are taken, is added sweeter than sub- sweet smell 2.5g, the unit of gentamicin 400,000, lidocaine 0.05g
Sugarcane juice 10g, pectin 20g, caramel 5g and corn syrup 10g form mixture；
(2) mixture that will be obtained in step (1), pours into lollipop mould and is pressed into that 0.5cm is thick, ellipse 2cm wide
Shape sugar structure, and plunger carries out condensation drying；
(3) a kind of glycyrrhiza compound lollipop for the treatment of of acute radiation oral mucositis is made after drying to be condensed terminates.
Preparation method 4, it is specific as follows：
(1) small fire decocts 10min after selection licorice 30g, plus 750ml bubbles 30min, and filtered juice removes slag, after natural cooling
It is standby into about 375ml.375ml liquorice liquids are taken, is added sweeter than sub- sweet smell 7.5g, the unit of gentamicin 1,200,000, lidocaine 0.15g
Sugarcane juice 30g, pectin 60g, caramel 15g and corn syrup 30g form mixture；
(2) mixture that will be obtained in step (1), pours into lollipop mould and is pressed into that 0.5cm is thick, ellipse 2cm wide
Shape sugar structure, and plunger carries out condensation drying；
(3) a kind of glycyrrhiza compound lollipop for the treatment of of acute radiation oral mucositis is made after drying to be condensed terminates.
Preparation method 5, it is specific as follows：
(1) small fire decocts 10min after selection licorice 20g, plus 500ml bubbles 30min, and filtered juice removes slag, after natural cooling
It is standby into about 250ml.250ml liquorice liquids are taken, is added than sub- sweet smell 5g, the unit of gentamicin 800,000, lidocaine 0.1g, sugar-cane juice
20g, pectin 40g, caramel 10g and corn syrup 20g form mixture；
(2) mixture that will be obtained in step (1), pours into lollipop mould and is pressed into that 0.5cm is thick, ellipse 2cm wide
Shape sugar structure, and plunger carries out condensation drying；
(3) a kind of glycyrrhiza compound lollipop for the treatment of of acute radiation oral mucositis is made after drying to be condensed terminates.
Clinical practice of the swallowing training pen of segmented administration of the present invention on treatment of acute radiation oral mucositis.Root
According to the state of an illness of patient, suitable Compound Glycyrrhiza is made, and the Compound Glycyrrhiza is sticked into the multi-functional of medicine support
On bar, medicine core is made.Medicine core is sequentially loaded into depositing in core cavity for swallowing training pen one by one, the medicine of medicine core foremost stretches out medicine
Product are exported, and then cover the cap for brush stand-by.The medicine core being put into penholder can use the medicine of different formulations or dosage, such as basis
Be arranged in order corresponding medicine core patient in penholder by the species of medication and medicine time every time.Put medicine well in advance, can avoid
Forget that the thing of medication occurs.
When patient will do swallowing training or diet, the cap for brush is removed, allow the hand-held penholder of patient to suck the medicine of penholder front end.
Preparation in medicine slowly melts in patient mouth, it is not easy to which choking the composition in patient, and medicine can play anesthesia oral cavity, subtract
The effect of few pain.If when only need on a small quantity take medicine and playing the effect of oral anesthestia, taking out swallowing training pen, and cover
The cap for brush, the medicine that remaining non-bedding and clothing are finished is hedged off from the outer world out.If now need to do oral rehabilitation training, as long as opening
Stock 151 on the cap for brush, and stock is extend into oral cavity, stimulate K points by raised 214 on stock, induce opening for patient
Mouthful and swallow startup.Or stock is used directly as spatula.
After medicine foremost has been taken, the Multifunctional rod in medicine support is exposed, using the Multifunctional rod
K points can be completed to stimulate or implements tongue pressure training as spatula.And now penholder can be used as Handheld Division, medical personnel's hand
The bar that holds a pen helps patient to complete swallowing training.
Therefore the medicine on the swallowing training pen of the segmented administration can be withdrawn from from oral cavity in time, can meet radiation
The requirement of property oral mucositis patient's divided doses.Be integrated for various swallowing training Tool integrations again by the swallowing training pen,
Make swallowing training more convenient.
Claims (10)
1. a kind of penholder of swallowing training pen for being segmented administration, including internal charge core, it is characterised in that：Core cavity is deposited in penholder
Two medicine cores can at least be accommodated to be arranged in order in it, the rear end of penholder is provided with push part, and the medicine in medicine core is pushed successively
To medicine exit, penholder front end is provided with clamping part, to keep medicine that penholder is not departed from during being used by clothes for patients.
2. swallowing training according to claim 1 pen, it is characterised in that the push part is piston type push structure or bullet
Spring structure.
3. swallowing training according to claim 1 pen, it is characterised in that the clamping part is selected from block piece, with card base
Fastener, or the projection bayonet socket on projection in medicine support and penholder.
4. swallowing training according to claim 1 pen, it is characterised in that the medicine support is hollow-core construction.
5. swallowing training according to claim 1 pen, it is characterised in that the front portion of the medicine support is equipped with functional bar, function
Bar is for platypelloid type and front end is provided with projection.
6. swallowing training according to claim 1 pen a, it is characterised in that vibration is mounted with the outer wall of the penholder
Device.
7. swallowing training according to claim 1 pen, it is characterised in that described also to include the cap for brush, the leading portion of the cap for brush is connected
The stock on the cap for brush is may be folded in, is connected by rotating shaft between the cap for brush and stock.
8. swallowing training according to claim 7 pen, it is characterised in that the front end of the stock is provided with projection.
9. swallowing training according to claim 1 pen, it is characterised in that the medicine is Compound Glycyrrhiza, institute's pastille
Thing includes liquorice liquid 175-350ml, than sub- sweet smell 2.5-7.5g, gentamicin 40-120 ten thousand unit, lidocaine 0.05-0.15g,
Auxiliary material and solid agent that appropriate nourshing Yin and drynsessmoistening prescription is promoted the production of body fluid.
10. swallowing training pen the facing on treatment of acute radiation oral mucositis that one of claim 1 to 9 segmented is administered
Bed application.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710195913.7A CN106693295B (en) | 2017-03-29 | 2017-03-29 | Swallowing training pen with segmented administration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710195913.7A CN106693295B (en) | 2017-03-29 | 2017-03-29 | Swallowing training pen with segmented administration |
Publications (2)
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| CN106693295A true CN106693295A (en) | 2017-05-24 |
| CN106693295B CN106693295B (en) | 2023-07-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710195913.7A Active CN106693295B (en) | 2017-03-29 | 2017-03-29 | Swallowing training pen with segmented administration |
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| Country | Link |
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|---|---|
| CN106693295B (en) | 2023-07-28 |
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