CN106692755A - Traditional Chinese medicine composition with functions of stopping bleeding, eliminating inflammation and preventing bacteria and preparation method and application of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition with functions of stopping bleeding, eliminating inflammation and preventing bacteria and preparation method and application of traditional Chinese medicine composition Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition with functions of stopping bleeding, eliminating inflammation and preventing bacteria and a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition consists of the following raw materials: 40-60 parts of ligusticum wallichii and 35-70 parts of lalang grass rhizome. The preparation method comprises the following steps: mixing and crushing the components, performing heating extraction with distilled water, performing vacuum filtration so as to obtain an extract of the medicinal materials, concentrating the extract, and performing vacuum freezing or spray drying, thereby obtaining the traditional Chinese medicine composition with the functions of stopping bleeding, eliminating inflammation and preventing bacteria. With the combination of the two medicines of the formula, the traditional Chinese medicine composition is capable of activating blood and circulating qi, clearing heat and stopping bleeding, eliminating inflammation and relieving pain as well as comprehensively regulating and coordinating internal organs of bodies, has functions of stopping bleeding, eliminating inflammation, preventing bacteria, refreshing oral smell and the like, and can be applied to prevention and treatment on bleeding gums, periodontitis, gingivitis and the like.
Description
Technical field
The present invention relates to field of medicine preparing technology, specially a kind of Chinese medicine composition with hemostasis and anti-inflammation antibacterial and its
Preparation method and application.
Background technology
Oral cavity is one of approach that pathogenic microorganism invades human body, the temperature in oral cavity, humidity and the suitable micro- life of swill
The growth and breeding of thing.Effective MC can keep the generation of oral cleaning and prevention mouth infection.Oral health into
For the World Health Organization evaluates one of important indicator of level of human health, the psychological need that oral hygiene is people, oral cavity are kept
Nursing is even more body care inalienable part.The articles for use for being used for oral hygiene in daily life are also increasingly various, such as tooth
Cream, tooth powder, mouthwash, tooth patch, oral spray, chewing gum etc..Oral problem common at present includes：Periodontitis, gingivitis,
Bleeding gums, canker sore, swelling and aching of gum etc..In recent years, as popular living standard is growing, people want to health
The raising asked, the culture rarity of this Chinese nation of Chinese herbal medicine is applied in MC, with safely, effectively and side effect
Smaller effect, is favored by more and more consumers.
Chinese herbal medicine oral care product form have still based on Chinese herbal toothpaste, mainly Radix zanthoxyli Chinese herbal toothpaste, six must
Control toothpaste, mica filled polypropylene, Darlie, Chinese toothpaste, Chloranthus glaber toothpaste, tianqi toothpaste, the clear toothpaste of health tooth etc..At present,
Mainly there are mica filled polypropylene, tianqi toothpaste, Lamiophlomis rotata toothpaste etc. in terms of for hemostasis and anti-inflammation, but produced from market entirety angle
Product are still relatively simple.With everybody concern to oral hygiene and oral peculiar smell, the consumer group of mouthwash is also being continuously increased, and gargles
The market scale of saliva also constantly expands.Most common brand has the graceful Hess of the Li Shidelin of Johson ＆ Johnson, Lay in China market
The shellfish tooth of the Wei Lushi of company, the Shu Ke brands of South Korea and Colgate-Palmolive company, and the black younger sister's product of domestic brand such as Mei Chen companies
The fast clean and mouth Thailand board mouthwash of board, but Chinese herbal medicine application is also fewer.At present, Chinese-medicine oral cavity nursing materials is produced on chewing gum
Product are more rare, only partial monopoly product but and do not go public, such as anti-dental caries chewing gum (ZL 2,014 1 0363586.8), prevention
Chinese medicine health-care chewing gum (0158458.X of ZL 2,014 1) of canker sore etc..
Ligusticum wallichii from samphire Ligusticum wallichii Ligusticum chuanxiong Hort. dry rhizome, main product in
The ground such as Sichuan Province Pengzhou, Dujiang weir.
Rhizoma imperatae is grass perennial herb cogongrass (scientific name:Imperata cylindrica) rhizome, nature and flavor
Gan Han.The main component of rhizoma imperatae is:Cylindrin, arundoin, serotonin, potassium, calcium etc..
The content of the invention
The present invention is just being directed to above technical problem, there is provided a kind of Chinese medicine composition and its system with hemostasis and anti-inflammation antibacterial
Preparation Method.The Chinese medicine composition has hemostasis and anti-inflammation antibacterial action, can enrich product category in MC market.
Another goal of the invention of the invention is to provide a kind of application of the Chinese medicine composition with hemostasis and anti-inflammation antibacterial.
Concrete technical scheme of the invention is as follows：
A kind of Chinese medicine composition with hemostasis and anti-inflammation antibacterial, said composition is prepared from by the raw material of following weight portion：
40~60 parts of Ligusticum wallichii, 35~70 parts of rhizoma imperatae.
Preferably, the Chinese medicine composition with hemostasis, antiphlogistic antibacterial is prepared from by the raw material of following weight portion：
40~50 parts of Ligusticum wallichii, 50~60 parts of rhizoma imperatae.
Preferably, it is described with obvious haemostatic effect, take into account the Chinese medicine composition of antiphlogistic antibacterial by following weight portion
Raw material is prepared from：40~43 parts of Ligusticum wallichii, 60~70 parts of rhizoma imperatae.
Preferably, it is described with obvious antiphlogistic antibacterial effect, the Chinese medicine composition of hemostasis is taken into account by following weight portion
Raw material is prepared from：55~60 parts of Ligusticum wallichii, 40~45 parts of rhizoma imperatae.
The preparation method of the Chinese medicine composition with hemostasis and anti-inflammation antibacterial, comprises the following steps：
1) weigh each raw material in proportion, then by above-mentioned each component co-grinding after, with distillation water heating extracting, depressurized
Filter obtains the extract solution of medicinal material；
2) by extract solution concentration, vacuum refrigeration or spray drying, the Chinese traditional medicine composition with hemostasis and anti-inflammation antibacterial is obtained final product
Thing.
It is preferred that a kind of preparation method of the Chinese medicine composition with hemostasis and anti-inflammation antibacterial, it is concretely comprised the following steps：
1), proportionally weight weighs each component respectively；
2) Ligusticum wallichii, is ground into meal, 30-50 mesh sieves are crossed；Rhizoma imperatae cuts into segment, every section of 2-3cm；
3) after, above-mentioned each component is mixed, add 8~10 times of distilled water of volume to heat (80-100 DEG C) and extract 2~3
Secondary, each extraction time is 2~3h, and filter cloth filtration, remerges filtrate after extracting every time, obtains mixture extract solution；
4), by step 3) prepare mixed extract 60~80 DEG C concentration, to relative density at 60 DEG C be 1.2~
1.4, obtain concentrate；
5) by step 4) concentrate that obtains with maltodextrin or soluble starch by 25~40：1 mass ratio is mixed
Close, stir；
6) by step 5) mixture is spray-dried or vacuum freeze drying is to powdered, and obtain final product and described disappear with hemostasis
The Chinese medicine composition of scorching antibacterial.Spray drying condition：190~220 DEG C of intake air temperature, 60~80 DEG C of air outlet temperature；Vacuum
Freeze-drying condition：- 0.10 DEG C of pre-freeze speed/min~-0.05 DEG C/min, 35~45 DEG C of temperature of heating plate, drying chamber pressure 60
~75Pa.
The Chinese medicine composition with hemostasis and anti-inflammation antibacterial is applied to prepare in oral care implement.Including toothpaste, clearly
Effervescent for cleaning, mouthwash, cleaning agent for mouth cavity, permanent tooth cream, chewing gum, permanent tooth powder or oral spray.
The positive effect of the present invention is embodied in：
(1), Traditional Chinese medicine composition formula of the invention, the experience gained in doctor's Clinical practice, in related oral disease
Good therapeutic effect is achieved in shape patient.
(2), double medicines are shared, can blood-activating and qi-promoting, clearing away heat to stop bleeding, anti-inflammatory analgetic, comprehensively conditioning, reach hemostasis, anti-inflammatory,
Antibacterial, fresh breath etc. are acted on, and can be used for the preventing and treating of bleeding gums, periodontitis, gingivitis etc..
(3), preparation method of the invention is easy to operate, and the instrument for being used can guarantee that the active ingredient effect of medicine, product
Quality guarantee hinders, and is easily esthetically acceptable to the consumers, and is adapted to industrialized production.
Brief description of the drawings：
Fig. 1 is flow process schematic diagram of the invention.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to specific embodiment pair
The present invention is described in further detail, but this scope for being interpreted as above-mentioned theme of the invention should not be only limitted into following implementations
Example.
Embodiment 1：
(1) 40 parts of Ligusticum wallichii meal, is weighed respectively according to part by weight, 60 parts of the rhizoma imperatae after segment；
(2) after, above-mentioned each component is mixed, 10 times of the addition distillation water heating extracting of volume 2~3 times, when extracting every time
Between be 3h, every time extract after filter cloth filtration, remerge filtrate, obtain mixture extract solution；
(3), the mixed extract for preparing step (2), in 70 DEG C of concentrations, is 1.0 (fluid temperatures 60 to relative density
DEG C), obtain concentrate；
(4) concentrate for obtaining step (3) and soluble starch are by 35：1 mass ratio is mixed, and is stirred；
(5) step (4) mixture is carried out into vacuum freeze drying to powdered, is obtained final product described with hemostasis, antiphlogistic antibacterial
The Chinese medicine composition I that both take into account.
Embodiment 2:
(1) 60 parts of Ligusticum wallichii meal, is weighed respectively according to part by weight, 40 parts of the rhizoma imperatae after segment；
(2) after, above-mentioned each component is mixed, 8~10 times of the addition distillation water heating extracting of volume 2~3 times is extracted every time
Time is 2~3h, and filter cloth filtration, remerges filtrate after extracting every time, obtains mixture extract solution；
(3), the mixed extract for preparing step (2), in 60~80 DEG C of appropriate concentrations, is 0.9~1.1 to relative density
(60 DEG C of fluid temperature), obtains concentrate；
(4) concentrate for obtaining step (3) and maltodextrin are by 30~35：1 ratio is mixed, and is stirred；
(5) step (4) mixture is spray-dried to powdered, obtain final product it is described have antiphlogistic antibacterial effect substantially,
Take into account the Chinese medicine composition II of hemostasis.
Embodiment 3：
(1) 40 parts of Ligusticum wallichii meal, is weighed respectively according to part by weight, 69 parts of the rhizoma imperatae after segment；
(2) after, above-mentioned each component is mixed, 8~10 times of the addition distillation water heating extracting of volume 2~3 times is extracted every time
Time is 2~3h, and filter cloth filtration, remerges filtrate after extracting every time, obtains mixture extract solution；
(3), the mixed extract for preparing step (2), in 60~80 DEG C of appropriate concentrations, is 0.9~1.1 to relative density
(60 DEG C of fluid temperature), obtains concentrate；
(4) concentrate for obtaining step (3) and maltodextrin are by 30~35：1 ratio is mixed, and is stirred；
(5) step (4) mixture is spray-dried to powdered, obtain final product it is described have haemostatic effect substantially, take into account
The Chinese medicine composition III of antiphlogistic antibacterial.
Embodiment 4：More than one state the toothpaste with hemostasis and anti-inflammation antibacterial of Chinese medicine composition preparation.
Formulation of tooth-paste, based on each parts by weight：400 parts of D-sorbite, 200 parts of hydrated SiO 2, PEG400
50 parts, 150 parts of glycerine, 200 parts of pure water, 10 parts of sldium lauryl sulfate, 10 parts of carragheen, 10 parts of xanthans, hydroxy ethyl fiber
5 parts of element, 35 parts of Chinese medicine composition I, 5 parts of flavoring essence, 1 part of saccharin, 1 part of Sodium Benzoate, 0.5 part of pigment CI42053.
Above-mentioned formulation of tooth-paste is prepared by toothpaste making process, obtains lotion of toothpaste, and aluminium-plastic pipe is entered using sterile filling
Or flexible pipe, obtain final product the finished toothpaste that antiphlogistic antibacterial is taken into account with hemostasis.
Toothpaste obtained above is carried out into clinical observation experiment, the cycle is one month, daily sooner or later daily brush during experiment
Tooth is used, the improvement situation of each subject oral cavity disease before and after observation experiment, as a result such as table 1 below.Test result indicate that, obtain
Toothpaste is to bleeding gums, gingivitis, periodontitis etc. with certain treatment and prevention effect.
The hemostasis of table 1 takes into account the observation of antiphlogistic antibacterial toothpaste clinical trial results
The antibacterial experiment in vitro of embodiment 5
1st, the preparation of culture medium：Pancreas junket soya peptone meat soup (TSB) 30g is taken, heating stirring is dissolved in 1000ml distilled water, from
Middle taking-up 300ml adds 8g agar powders, and heating dissolves it, used as solid medium；Remaining 700ml as fluid nutrient medium,
Packing sterilizing.
2nd, inoculum：In the test tube that fluid nutrient medium after above-mentioned sterilizing is poured into after sterilizing (at about 1/3), respectively
4 kinds of bacteriums (staphylococcus aureus, pseudomonas aeruginosa, Candida albicans, MRSE) of inoculation, every kind of microbionation
2h is cultivated in 2 test tubes, with 37 DEG C of constant incubators.
3rd, the preparation of hemostasis and anti-inflammation antibacterial Chinese medicine composition II powder sample solution：Take hemostasis and anti-inflammation antibacterial Chinese medicine composition
I powder 1g, plus distilled water diluting is to 10ml；Ligusticum wallichii control group, takes Szechwan Lovage Rhizome (according to technological process system of the invention
It is standby) 1g, plus distilled water diluting is to 10ml；Rhizoma imperatae control group, takes lalang grass rhizome (according to technological process system of the invention
It is standby) 1g, plus distilled water diluting is to 10ml；Chinese medicine composition control group, takes Chinese medicine composition control group powder (20 parts of Ligusticum wallichii, white
80 parts of lalang grass rhizome, prepares according to technological process of the invention) 1g, plus distilled water diluting is to 10ml.
4th, experimental technique：In the culture dish that solid medium after sterilizing is poured into after sterilizing, by 4 kinds of inoculums point
It is not spread evenly across on culture medium, takes the 2 drum rims central area adhered on culture medium symmetrically, each strain is parallel
Do 2.The sample solution 100ul for taking step 3 preparation is injected in corresponding steel ring, and culture dish is placed in 37 DEG C of constant incubators
Culture 24h.The diameter of the similar round antibacterial region of test sample and average respectively, the size according to antibacterial region diameter come
The antibacterial ability of evaluate sample.
5th, experimental result：In Vitro Bacteriostasis rate the results are shown in Table 2.Knowable to following table result, pharmaceutical composition of the invention has
Antibacterial action, the fungistatic effect of one-component Ligusticum wallichii, rhizoma imperatae and Chinese medicine composition control group is much worse than Chinese medicine composition
II。
The In Vitro Bacteriostasis rate result of table 2
The bleeding time of embodiment 6 tests
SD mouse are randomly divided into 8 groups, every group 10, male and female half and half.Blank group；Yunnan Baiyao group, is Yunnan Baiyao
0.308g/kg；Chinese medicine composition III powder 2.872,1.436,0.718g/kg, high, medium and low 3 dosage groups；Ligusticum wallichii is compareed
Group, takes Szechwan Lovage Rhizome (being prepared according to technological process of the invention) 1.501g/kg；Rhizoma imperatae control group, takes rhizoma imperatae powder
End (being prepared according to technological process of the invention) 1.512g/kg；Chinese medicine composition control group, takes Chinese medicine composition control group
Powder (20 parts of Ligusticum wallichii, 80 parts of rhizoma imperatae are prepared according to technological process of the invention) 1.520g/kg；8 groups altogether.
Weighed Mouse Weight after packet, by body weight gavage medicine, the isometric distilled water of blank group gavage, gavage volume is equal
It is 25ml/kg.Once a day, continuous 2 days, 1h after last dose was being cut with scissors at Mouse Tail-tip 0.5cm respectively, treats blood
Liquid starts timing after flowing out naturally, and drop of blood is sucked 1 time every 15s filter paper, until blood stops (without blood when filter paper is inhaled naturally
Mark) untill, stopwatch record, as bleeding time.(Lu Rumei, Zhang Hongjian, Zhao Hongyan wait Soda-apple Night-shade Herbs the different extracted parts to stop blooding
Effect study [J] contemporary Chinese medical magazines, 2011,13 (11)；26-28. shellfishes space flies, and Chen Jun, Dai Jianping wait Uroctea compatilis Koch. charcoals etc.
Six kinds of charcoal drug anti-inflammatories, analgesia, the comparative studies of styptic activity [J] .. Chinese patent drugs, 2009,31 (11)；Zhao's 1722-1724. strong wind,
Chen Wei, Shu Kunxian, wait scorching gram of particle hemostatic mechanism research [J] contemporary Chinese medical journal of woman, 2002,12 (6):67-68.)
Influence to the mouse bleeding time, the results are shown in Table 3.It can be seen from result, Chinese medicine composition III powder is high, medium and low
The dosage group bleeding time is significantly lower than blank group (P<0.01), and it is much better than rhizoma imperatae control group, Ligusticum wallichii control group, Chinese traditional medicine composition
Thing control group, illustrates the compatibility of this component better than one-component, better than the compatibility beyond invention component.
Influence of the hemostasis and anti-inflammation antibacterial Chinese medicine composition of table 3 to the mouse bleeding time
Note：Administration group compares * * P with blank group<0.01, * P<0.05.
Embodiment 7：More than one state the artificial tooth effervescent table for cleaning of Chinese medicine composition II preparations.Artificial tooth table can effectively be eliminated
Face bacterium, reduces the appearance of gingivitis.
Effervescent tablet formula：19 parts of citric acid, 2.5 parts of nonanoyl oxygen benzene sulfonate, 2.5 parts of sodium carboxymethylcellulose, PEG-
4000 0.5 parts, 35 parts of saleratus, 29 parts of SODIUM PERCARBONATE, 10 parts of sodium perborate, 0.5 part of hydrolysising protease, Chinese medicine composition
1 part of II.
Preparation method：
Step (1)：Citric acid, nonanoyl oxygen benzene sulfonate, sodium carboxymethylcellulose, PEG-4000 etc. are weighed in proportion
Afterwards, it is well mixed and crushes；
Step (2)：Saleratus, Chinese medicine composition II, hydrolysising protease etc. are mixed and crushed again, step (1) is added
Mixed in powder；
Step (3)：Remaining formula spice is added, is sufficiently stirred for, be well mixed；
Step (4)：After by step (3) mixture tabletting machine, effervescent table for cleaning is obtained final product.
The artificial tooth effervescent table for cleaning extracorporeal bacteria inhibitor test of Chinese medicine composition II
1), the preparation of culture medium：Pancreas junket soya peptone meat soup (TSB) 30g is taken, heating stirring is dissolved in 1000ml distilled water,
It is taken out 300ml and adds 8g agar powders, heating dissolves it, used as solid medium；Remaining 700ml is used as Liquid Culture
Base, packing sterilizing.
2), inoculum：In the test tube that fluid nutrient medium after above-mentioned sterilizing is poured into after sterilizing (at about 1/3), point
Not Jie Zhong 4 kinds of bacteriums (staphylococcus aureus, pseudomonas aeruginosa, Candida albicans, MRSE), every kind of bacterium connects
2h is cultivated in kind 2 test tubes, with 37 DEG C of constant incubators.
3), the preparation of effervescent table for cleaning powder sample solution：Effervescent table for cleaning powder 1g is taken, plus distilled water diluting is extremely
10ml。
4), experimental technique：In the culture dish that solid medium after sterilizing is poured into after sterilizing, by 4 kinds of inoculums
It is spread evenly across on culture medium respectively, takes the 2 drum rims central area adhered on culture medium symmetrically, each strain is put down
Row does 2.The sample solution 100ul for taking step 3 preparation is injected in corresponding steel ring, and culture dish is placed in into 37 DEG C of constant incubators
Middle culture 24h.The diameter of the similar round antibacterial region of test sample and average respectively, according to the size of antibacterial region diameter
Carry out the antibacterial ability of evaluate sample.
5), experimental result：In Vitro Bacteriostasis rate the results are shown in Table 4.Knowable to following table result, effervescent table for cleaning medicine of the invention
Composition has preferable antibacterial action.
The effervescent table for cleaning In Vitro Bacteriostasis rate result of table 4
Embodiment 8：More than one state the lozenge with hemostatic function of Chinese medicine composition III preparations.The lozenge have compared with
Good is in good taste, and can promote to absorb, and can be used for the symptoms such as daily maintenence bleeding gums.
Containing slice prescription：60 parts of xylitol, 5 parts of glucose, maltodextrin 11,1 part of citric acid, 1 part of Chinese medicine composition III,
0.5 part of magnesium stearate, talcum powder 0.5,75% 21 parts of ethanol.
Preparation method：(except magnesium stearate lubricant, talcum powder) is weighed in proportion containing slice prescription by above-mentioned, is well mixed；
Constantly it is added dropwise in mixture with 75% ethanol binder, reaches and hold the i.e. scattered state of agglomerating light pressure, after uniformly spreading out, is put into
50 DEG C of oven for drying.The particle of drying is crossed into 30 mesh pharmacopeia sieve, lubricant (magnesium stearate, talcum are added in dry particle
Powder), after stirring and evenly mixing, compressing tablet obtains final product the lozenge with hemostatic function.
The lozenge hemostasis of Chinese medicine composition III, anti-inflammatory clinical test
The lozenge of above-mentioned Chinese medicine composition III is carried out into clinical observation experiment, the cycle is one month, is made daily during experiment
With 2~3 lozenges, the improvement situation of each subject oral cavity disease before and after observation experiment, as a result such as table 5 below.Test result indicate that,
The lozenge of Chinese medicine composition III is to bleeding gums, gingivitis etc. with certain treatment and prevention effect.
The lozenge clinical trial results observation of the Chinese medicine composition III of table 5
From examples detailed above, Chinese medicine composition of the invention has anti-inflammatory, antibacterial, hemostasis effect, and can apply
In oral care implement, described oral care implement includes toothpaste, effervescent table for cleaning, lozenge, mouthwash, oral cleaning
The formulations such as agent, permanent tooth cream, chewing gum, permanent tooth powder, oral spray.
The foregoing description of the disclosed embodiments, enables professional and technical personnel in the field to realize or uses the present invention.
Various modifications to these embodiments will be apparent for those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, the present invention
The embodiments shown herein is not intended to be limited to, and is to fit to and principles disclosed herein and features of novelty phase one
The scope most wide for causing.
Claims (8)
1. a kind of Chinese medicine composition with hemostasis and anti-inflammation antibacterial, it is characterised in that said composition by following weight portion raw material system
It is standby to form：40 ~ 60 parts of Ligusticum wallichii, 35 ~ 70 parts of rhizoma imperatae.
2. there is hemostasis, the Chinese medicine composition of antiphlogistic antibacterial according to claim 1, it is characterised in that said composition is by following
The raw material of weight portion is prepared from：40 ~ 50 parts of Ligusticum wallichii, 50 ~ 60 parts of rhizoma imperatae.
3. there is obvious haemostatic effect according to claim 1, the Chinese medicine composition of antiphlogistic antibacterial is taken into account, it is characterised in that should
Composition is prepared from by the raw material of following weight portion：40 ~ 43 parts of Ligusticum wallichii, 60 ~ 70 parts of rhizoma imperatae.
4. there is obvious antiphlogistic antibacterial effect according to claim 1, the Chinese medicine composition of hemostasis is taken into account, it is characterised in that should
Composition is prepared from by the raw material of following weight portion：55 ~ 60 parts of Ligusticum wallichii, 40 ~ 45 parts of rhizoma imperatae.
5. there is the preparation of the Chinese medicine composition of hemostasis and anti-inflammation antibacterial according to any one claim in claim 1 ~ 4
Method, it is characterised in that comprise the following steps：
1）Weigh each raw material in proportion, then by above-mentioned each component co-grinding after, with distillation water heating extracting, filtration under diminished pressure obtains
To the extract solution of medicinal material；
2）By extract solution concentration, vacuum refrigeration or spray drying, the Chinese medicine composition with hemostasis and anti-inflammation antibacterial is obtained final product.
6. there is the preparation method of the Chinese medicine composition of hemostasis and anti-inflammation antibacterial according to claim 5, it is characterised in that its tool
Body step is：
1）, proportionally weight weigh each component respectively；
2）, Ligusticum wallichii is ground into meal, rhizoma imperatae cuts into segment；
3）, above-mentioned each component is mixed after, add 8 ~ 10 times of distillation water heating extractings of volume 2 ~ 3 times, each extraction time is 2
~ 3h, filter cloth filtration, remerges filtrate after extracting every time, obtains mixture extract solution；
4）, by step 3）The mixed extract of preparation, in 60 ~ 80 DEG C of concentrations, is 1.2 ~ 1.4 to relative density at 60 DEG C, is obtained
Concentrate；
5）By step 4）The concentrate for obtaining is with maltodextrin or soluble starch by 25 ~ 40：1 mass ratio is mixed, and is stirred
Mix uniform；
6）By step 5）Mixture is spray-dried or vacuum freeze drying, obtains final product the Chinese medicine with hemostasis and anti-inflammation antibacterial
Composition.
7. a kind of Chinese medicine composition with hemostasis and anti-inflammation antibacterial as described in any one claim in claim 1 ~ 4 is in system
Application in standby oral care implement.
8. there is the Chinese medicine composition of hemostasis and anti-inflammation antibacterial answering in oral care implement is prepared according to claim 7
With, it is characterised in that it is used to preparing oral care implement, including toothpaste, effervescent table for cleaning, mouthwash, cleaning agent for mouth cavity, solid
Tooth cream, chewing gum, permanent tooth powder or oral spray.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110412199A (en) * | 2019-07-18 | 2019-11-05 | 四川绿色本草科技发展有限公司 | A kind of quality determining method of Rhizoma Chuanxiong toothpaste |
| CN111388610A (en) * | 2020-04-09 | 2020-07-10 | 四川绿色本草科技发展有限公司 | Traditional Chinese medicine composition for preventing gingival atrophy and/or treating gingivitis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311131A (en) * | 2015-06-16 | 2016-02-10 | 厦门医学高等专科学校 | Traditional Chinese medicine composition with antibacterial and anti-inflammation functions and preparation method and application of traditional Chinese medicine composition with antibacterial and anti-inflammation functions |
| CN105997774A (en) * | 2016-05-10 | 2016-10-12 | 芜湖亮晶晶生物科技有限公司 | Hemostatic and anti-inflammatory toothpaste and preparation method thereof |
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2017
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105311131A (en) * | 2015-06-16 | 2016-02-10 | 厦门医学高等专科学校 | Traditional Chinese medicine composition with antibacterial and anti-inflammation functions and preparation method and application of traditional Chinese medicine composition with antibacterial and anti-inflammation functions |
| CN105997774A (en) * | 2016-05-10 | 2016-10-12 | 芜湖亮晶晶生物科技有限公司 | Hemostatic and anti-inflammatory toothpaste and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110412199A (en) * | 2019-07-18 | 2019-11-05 | 四川绿色本草科技发展有限公司 | A kind of quality determining method of Rhizoma Chuanxiong toothpaste |
| CN111388610A (en) * | 2020-04-09 | 2020-07-10 | 四川绿色本草科技发展有限公司 | Traditional Chinese medicine composition for preventing gingival atrophy and/or treating gingivitis |
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| CN106692755B (en) | 2019-12-20 |
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