CN106692313A - 三藤醒脑组合物、药物制剂及其应用 - Google Patents
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Abstract
本发明属于中药领域,具体涉及一种醒脑药物/组合物,以及三藤醒脑药物制剂,以及上述的药物或制剂的应用。本发明的三藤醒脑组合物的特征是,主要包括海风藤、大血藤、青风藤。本发明的有益效果在于,将功效主要是祛风活血通络的海风藤、大血藤、青风藤结合起来,辅以其它的药物,共同起到了预防和治疗脑血管供血不足、神经***疾病、抗衰老、糖尿病、疲劳综合症、老年痴呆症等疾病的作用。
Description
技术领域
本发明属于中药领域,具体涉及一种三藤醒脑组合物,还涉及三藤醒脑药物制剂,以上上述的组合物和药物的应用。
背景技术
随着人类社会经济的发展,人民生活水平的提高和人口老龄化进程的加快,慢性非传染性疾病(简称慢性病)已经成为21世纪全球最紧迫的公共卫生问题之一,给世界范围内人民的健康和生活带来了巨大的影响。伴随着生活方式、膳食结构、消费娱乐方式、工作内容与工作方式以及经济关系和人际关系的交往方式的改变,我国的疾病谱和死因构成比也在发生变化,以心脑血管疾病、肿瘤、糖尿病等为代表的慢性非传染性疾病(简称慢性病)正日益威胁着人民的健康,已经成为严重的社会公共问题和医疗经济增长的阻碍。
上个世纪90年代末,我国就完成了疾病谱的转变,死亡的主要原因已由急性传染性疾病转变为慢性病,完成了由生物医学模式向现代医学模式的转变。传染病的死因顺位下降,慢性病所致的死亡已占死亡原因的前三位。
目前中国人健康大数据概况
中国高血压人口有1.6----1.7亿人
高血脂的有将1亿多人
糖尿病患者达到9240万人
超重或者肥胖症7000万-----2亿人
血脂异常的1.6亿人
脂肪肝患者约1.2亿人
平均每30秒就有一个人罹患癌症
平均每30秒就有一个人罹患糖尿病
平均每30秒,至少有一个人死于心脑血管疾病,目前年轻人因为突发心梗而死亡的比例越来越高
肿瘤发生率21.2%,平均每6秒钟一个肿瘤患者,10年后,肿瘤发生率在此基础上将要翻一倍····
随着科技的发展,医疗水平越来越高,人们越来越关注资深的健康,然而疾病的种类却并没有因此而减少,疾病的发病率也越来越高!
当今社会,亚健康的人群越来越多,已经成为普遍现象,每个人身上的毒垢就像定时炸弹一样积累到一定程度就会爆发疾病。例如,当毒垢堆积在心脏里,心脏负担加重,每跳一下就相当于跳了好几下,很多刚过40的中年人就是因为这个过早的罹患心脏病。
毒垢对人体有以下的危害:毒垢在躯干四肢,就会腰疼、腿疼、全身疼。毒垢在脏腑,就会使五脏发生病变、身体平衡打乱;毒垢在血液,就会污染血液,引发心脑血管病变。脂肪肝、酒精肝、肝硬化、痛风、动脉硬化、高血脂、高血压、中风、偏瘫、冠心病、心率不齐、胸闷气短。
目前关于上述的各种慢性病的治疗方法,通常是以下的手段:对于心梗患者,采用手术治疗放支架的方式;对于肿瘤患者,采用手术、化疗的方式。虽然以上的治疗方式暂时缓解了病人的痛苦,但是并不能彻底的起到治疗的作用。通过手术治疗的方式是在为治病而治病,并没有从本质上解决了根本病因,导致的结果就是反复用药、手术,再用药,再手术,却无法彻底治愈病患,甚至产生毒副作用,加速死亡。现在的许多医学专业性太强,各科室分工细化,又大大限制了医疗水平的发挥。从根本上来说,人体是一个整体,人体并不是一个个器官的组合,但现在的许多治疗方法却是将人分割成一块块器官或是组织了,因此,才导致了某些疾病尤其是某些慢性疾病久治不愈,不能断根。
事实上,人的生命取决于血管通畅、淋巴通畅、气脉通畅,这3条生命通道出了问题,如果早期解决,就不会得病;相反,长时间不通畅,就会出现各种毛病,感觉容易疲劳、失眠,打呼噜,甚至心梗、中风及肿瘤。现在肿瘤已经成为一种慢性病,但却鲜见心脏癌症患者,就是因为心脏不停的循环,癌细胞没有停留的机会,所以心脏没有癌症。因此,一切健康管理的核心是要维持上述生命通道的通畅,做到“上医治未病” 。
因此,需要将人体作为一个有机的整体,来研究各种疾病或是慢性疾病的治疗方法或治疗药物,而并不是拆解开来,针对某种疾病本身舍本逐末的治疗。
发明内容
为了解决上述的技术问题,本发明提供了一种疗效显著的治疗各种慢性疾病尤其是预防和治疗健忘、记忆力下降、头疼、头晕、耳鸣、脑鸣症状的三藤醒脑中药组合物。
本发明通过整合医学的方法,也可以说中西医结合的方法,根据发明人30年医学研究,独创性的发明了三藤醒脑组合物,通过该药物来疏通血管通畅、淋巴通畅、气脉通畅,排出细胞的毒素,恢复自身细胞的修复力与免疫力,进而恢复器官组织的功能活力,已经为诸多慢性病患者彻底的治愈了许多慢性病,例如高血压、糖尿病、痛风、严重失眠等都取得了良好效果。采用本发明的药物抗衰老治疗的同时,由于恢复自身细胞的修复力与免疫力,很意外的同时也治疗了诸多慢性疾病。
本发明的三藤醒脑组合物,主要包括海风藤、大血藤、青风藤。
上述的三藤醒脑组合物是包括海风藤、大血藤、青风藤的提取物。
上述的三藤醒脑组合物是包括海风藤、大血藤、青风藤、丹参、丹皮、三七、柴胡、郁金、红花、桃仁、当归、金蝎子、蜈蚣、陈皮、砂仁、生薏仁、泽泻、天麻的提取物。
该提取物可以是水提取物,或者是以其它原料作为溶剂所得到的提取物,比如醇提取;或者是以其它方法提取,比如微波提取法、超声波提取法、超临界二氧化碳提取法、逆流提取法等,像采用上述的提取方法所得的提取物,也是在本发明的保护范围之内。
上述的三藤醒脑组合物,其中的提取是用水煎煮提取,水煎煮提取的次数是3次。
优选的,本发明的三藤醒脑组合物在以上三种主要原料的基础上,佐以其它原料药,得到疗效更好、治疗范围更广的药物,具体包括下述重量份数的原料:
海风藤10-20 大血藤 20-40 青风藤10-20
丹参 10-20 丹皮8-12 三七1-5
柴胡8-12 郁金8-12 红花4-8
桃仁8-12 当归8-12 金蝎子 8-12
蜈蚣8-12 陈皮8-12 砂仁15-25
生薏仁25-35 泽泻 5-15 天麻8-12 。
更优选的,三藤醒脑组合物包括下述重量份数的原料:
海风藤15 大血藤 30 青风藤15
丹参 15 丹皮10 三七3
柴胡10 郁金10 红花 6
桃仁10 当归10 金蝎子 10
蜈蚣10 陈皮12 砂仁20
生薏仁30 泽泻 10 天麻10 。
上述的三藤醒脑组合物和药学上可接受的辅料。
上述的三藤醒脑药物制剂,该制剂为片剂、胶囊剂、丸剂、汤剂中的任一种,也可以是其它的医学上可行的药物制剂。
三藤醒脑药物制剂为丸剂,其制备方法如下:
(1)按权利要求2中的重量份数取以下的原料:海风藤、大血藤、青风藤、丹参、丹皮、三七、柴胡、郁金、红花、桃仁、当归、金蝎子、蜈蚣、陈皮、砂仁、生薏仁、泽泻、天麻,粉碎,混匀,得原料药粉;
(2)在上述的粉碎的原料药粉中加入水或/和蜂蜜,调成糊状;
(3)采用压丸机制成丸剂,即得。
优选的,步骤(2)为:在上述的粉碎的原料药粉中加入水、蜂蜜,调成糊状;
原料药粉:水:蜂蜜的重量比为1:0.2:0.8;
以上的三藤醒脑组合物或药物制剂,在治疗脑血管供血不足、神经***疾病、抗衰老、糖尿病、疲劳综合症、老年痴呆症中的应用,也是本发明所要保护的范围。
本发明在三藤这三种主要原料的基础上辅以其它的中药原料配伍,达到了共同治疗脑血管供血不足、神经***疾病、抗衰老、糖尿病、疲劳综合症、老年痴呆症等脑部及神经疾病的作用。
三藤的作用本来是活血化淤的,但是它们组合或它们与其它的原料结合之后,发现并不是药物本身的功效,而是能达到治疗或者是预防健忘、记忆力下降、头疼、头晕、耳鸣、脑鸣的功效。具体分析如下:
海风藤的作用,祛风湿,通经络,止痹痛。用于风寒湿痹,肢节疼痛,筋脉拘挛,屈伸不利。与羌活、独活、桂心、当归等同用,可用于风寒湿痹,肢节疼痛,筋脉拘挛,屈伸不利者。与三七、地鳖虫、红花等同用,可用于跌打损伤,瘀肿疼痛者。
大血藤:其主要的功效是,败毒消痈,活血通络,祛风杀虫的作用。治急、慢性阑尾炎,风湿痹痛,赤痢,血淋,***,疳积,虫痛,跌扑损伤。
相关配方如下:
(1)治肠痈,生于小肚角,微肿而小腹隐痛不止者是,若毒气不散,渐大,内攻而溃,则成大患:红藤一两许,以好酒二碗,煎一碗,午前一服,醉,卧之。午后用紫花地丁一两许,亦如前煎服,服后痛必渐止为效。然后以当归五钱,蝉退、僵蚕各二钱,天龙、大黄各一钱,石礍蚆五钱(此草药),老蜘蛛二个(捉放新瓦上,以酒钟盖定,外用火煅干存性),共为末,每空心用酒调送一钱许,日逐渐服自消。(《景岳全书》)
(2)治急、慢性阑尾炎,阑尾脓肿:红藤二两,紫花地丁一两。水煎服。(《浙江民间常用草药》)
(3)治风湿筋骨疼痛,经闭腰痛:大血藤六钱至一两。水煎服。(《湖南农村常用中草药手册》)
(4)治风湿腰腿痛:虹藤、牛膝各三钱,青皮、长春七、朱砂七各二钱,水煎服。(《陕西中草药》)
(5)治肠胃炎腹痛:大血藤三至五钱,水煎服。(《浙江民间常用草药》)
(6)治钩虫病:大血藤、钩藤、喇叭花、凤叉蕨各三钱,水煎服。(《湖南农村常用中草药手册》)
(7)治小儿疳积,蛔虫或蛲虫症:红藤五钱,或配红石耳五钱,共研细末,拌白糖食。(《陕西中草药》)
(8)治小儿蛔虫腹痛:红藤根研粉,每次吞服一钱半。(《浙江中医杂志》6:1959)
(9)治跌打损伤:大血藤,骨碎补各适量共捣烂,敷伤处。(《湖南农村常用中草药手册》)
(10)治血虚经闭:大血藤五钱,益母草三钱,叶下红四钱,香附二钱。水煎,配红砂糖适量调服。(《闽东本草》)
(11)治血崩:红藤、仙鹤草、茅根各五钱。水煎服。(《湖南药物志》)
青风藤:祛风湿,通经络,利小便。用于风湿痹痛,关节肿胀,麻痹瘙痒。祛风湿,利小便。治风湿痹痛,鹤膝风,水肿,脚气。
(1)《本草图经》:治风。
(2)《纲目》:治风湿流注,历节鹤膝,麻痹瘙痒,损伤疮肿,入酒药中用。
(3)《浙江天目山药植志》:行水利尿,泻下焦血分湿热。治风水肿,脚气,风湿关节疼痛,口眼歪斜,痈肿恶疮。
(4)《中国药植志》:除湿,祛风,行气,利水。治膀胱水肿,风肿,脚气湿肿。
(5)《温岭县药物资源名录》:驱风湿,通经络。治风寒湿痹,鹤膝风,肢节肿痛。
【用法用量】内服,煎汤,3~5钱;浸酒或熬膏。外用:煎水洗。
以上的三藤(海风藤、大血藤、青风藤)其主要功效是,祛风湿,活血通络,止痹痛、败毒消痈,祛风杀虫、利小便;用于风湿痹痛,关节肿胀,麻痹瘙痒;但是三藤组合之后,却能起到脑血管供血不足、神经***疾病、抗衰老、糖尿病、疲劳综合症、老年痴呆症的作用。
尤其是三藤与其它的原料药物结合之后,对各种慢性疾病例如心脑血管疾病、神经***疾病、抗衰老、糖尿病、疲劳综合症、老年痴呆症等的治疗有显著的治疗作用。
本发明的有益效果在于,将功效主要是祛风活血通络的海风藤、大血藤、青风藤结合起来,辅以其它的药物,共同起到了预防和治疗脑血管供血不足、神经***疾病、抗衰老、糖尿病、疲劳综合症、老年痴呆症等疾病的作用。
具体实施方式
下面结合具体实施例对本发明作更进一步的说明,以便本领域的技术人员更了解本发明,但并不因此限制本发明。
实施例1
(1)按以下的重量份数取各原料药物:
海风藤15 大血藤 30 青风藤15
丹参 15 丹皮10 三七3
柴胡10 郁金10 红花 6
桃仁10 当归10 金蝎子 10
蜈蚣10 陈皮12 砂仁20
生薏仁30 泽泻 10 天麻10 ;
粉碎至100目,得原料药粉;
(2)将上述的原料药粉与水、蜂蜜相混合,搅拌均匀;原料药粉:水:蜂蜜的重量比为1:0.2:0.8;
(3)采用压丸机制成丸剂,即得三藤醒脑丸。
临床案例:
1 治疗脑血管供血不足案例:
姓名:梁某 性别:女;年龄:62岁 职业:退休干部;
症状:高血压、高血脂,脑供血不足,常头痛头晕,心慌胸闷,睡眠质量差,夜间经常需要开窗户睡觉,易疲劳没精神。心电图显示:心肌劳损。
用法用量:
每次服用水丸10克,每日2次,早晚各一次,服用的时间20天一个疗程;每10克药物中有效原料生药为 11 克。
效果跟踪:
经三藤醒脑丸治疗2个疗程后,血压血脂指标均正常,头痛减轻,皮肤有光泽,紧致细腻,睡眠好,精力充沛,头疼、头晕、脑鸣症状消失,记忆力明显增强。 再次检查心电图,为正常心电图。
2治疗神经***疾病病例:
姓名:黄某 性别:男 年龄:85岁 职业:新四军老干部;
症状:因脑出血,左侧肢体活动不灵,大脑供血不足,表情淡漠,睡眠质量差,常年吃***,打呼噜,没精神,常年卧床。
治疗前:意识清晰,言语自如,左眼视力减弱,左侧鼻唇沟变浅,左侧鼓气露齿,吹口哨欠佳,伸舌偏左,左侧肢体肌力三级,肌张力增高,右侧肢体肌力五级,肌张力正常。左手精细运动及协调性差。左侧指鼻运动,指指运动,轮替实验,跟膝胫反射均不能完成。左侧生理反射亢进,病理反射巴氏征阳性。
用法用量:
每次服用水丸10克,每日2次,早晚各一次,服用的时间20天一个疗程;每10克药物中有效原料生药为 11 克。
效果跟踪:
经三藤醒脑丸治疗后,表情丰富,睡眠质量好,打呼噜减轻,皮肤有光泽,紧致细腻,精神十足,言语明显增多,吹口哨运动明显好转。左侧上肢体肌力4级,左侧下肢体肌力4+级,肌张力明显减低,左手协调性好,精细运动欠佳,左侧指鼻运动,指指运动,轮替实验,跟膝胫反射完成较理想。左侧生理反射正常,病理反射巴氏征阳性。
3 抗衰老病例:
姓名:孙某 性别:女,年龄:50岁。症状:更年期综合征,面部皮肤暗黄,黄褐斑明显,睡眠质量差,偏头疼,颈椎痛,全身乏力,小腹赘肉越堆积越多,平时感觉走路没有力气,口气重,一年前,患上患上便秘,大便很干,次数少,时间长。
用法用量:
每次服用水丸10克,每日2次,早晚各一次,服用的时间20天一个疗程;每10克药物中有效原料生药为 11 克。
效果跟踪:
经三藤醒脑丸治疗2个疗程后,顾客身体状况良好,面部紧致细腻有光泽,皮肤白嫩,睡眠好,精神好,颈椎痛消失,出虚汗、五心烦热等更年期症状消失。
4治疗糖尿病病例:
姓名:孙某 性别:男, 年龄:80岁。1989年患糖尿病,经饮食控制及服用优降糖和二甲双胍等,血糖维持在10.1-15.2mmol/l之间,尿糖(+++)-(++++),酮体(++),96年病情加重,开始用胰岛素20-26u/日控制,血糖在4.9-7.3mmol/l之间, 足背出现溃疡数年未愈合,下地走路足部疼痛明显,脑血栓后遗症,记忆力减退,语言沟通困难。
用法用量:
每次服用水丸10克,每日2次,早晚各一次,服用的时间20天一个疗程;每10克药物中有效原料生药为 11 克。
效果跟踪:
经三藤醒脑丸治疗2个疗程后,顾客身体状况逐渐好转,话语明显增多,足部皮肤由硬***,颜色由黑逐渐变浅,足部皮温正常,疼痛减轻,足背溃疡面愈合,药量减半血糖仍控制良好。
5治疗疲劳综合在案例:
姓名:曹博士 性别:男,年龄:50岁 职业:军队***干部。症状:身体易疲劳,年轻时因为心肌炎住院半年,经常胸闷心慌,易疲劳,近来逐渐发胖,睡眠打呼噜、磨牙厉害
用法用量:
每次服用水丸10克,每日2次,早晚各一次,服用的时间20天一个疗程;每10克药物中有效原料生药为 11 克。
效果跟踪:
经三藤醒脑丸治疗1个疗程后,身体状况明显好转,皮肤白细,精力旺盛,睡眠质量好,打呼噜、磨牙消失,肌肉紧实,心慌胸闷症状消失。不论是照片还是个人的精神状态改变很大,治疗后感觉浑身有劲,眼睛清楚明亮,睡眠变好,不磨牙,连呼噜也不打了。
7.治疗老年痴呆案例
李某,女,65岁。家族遗传性老年痴呆,60岁以后记忆力明显下降,经常忘事,下雨阴天外出活动经常回不了家,表情木讷,语言减少,耳鸣脑鸣严重影响生活质量。
用法用量:
每次服用水丸10克,每日2次,早晚各一次,服用的时间20天一个疗程;每10克药物中有效原料生药为 11 克。
效果跟踪:经过三藤醒脑丸治疗后,记忆力明显进步,语言增多,思维清晰,耳鸣脑鸣症状消失。
实施例2
(1)按以下的重量取各原料药物:
海风藤10g 大血藤 20 g 青风藤10 g
丹参 10 g 丹皮8 g 三七1 g
柴胡8 g 郁金8 g 红花4 g
桃仁8 g 当归8 g 金蝎子 8 g
蜈蚣8 g 陈皮8 g 砂仁15 g
生薏仁25 泽泻 5 g 天麻8 g;
(2)将以上的药物浸泡半小时,水的加入量为原料药物重量的5倍;
(3)武火烧开,文火煎煮15-20分钟,过滤,得滤液;再加入原料药重量3倍的水,武火烧开,文火煎煮15-20分钟,过滤,得滤液;将两次的滤液合并,得汤剂。
用法与用量:
每日早晚各服用一次,7天为一疗程,总共服用2个疗程。
临床案例:
1 治疗脑鸣、耳鸣案例:
姓名:王某 性别:男;年龄:62岁 职业:退休干部;
症状:高血压、高血脂,脑供血不足,常头痛头晕,心慌胸闷,睡眠质量差,经常脑鸣、耳鸣,易疲劳没精神。
用法用量:
每次服用汤剂一袋,每日2次,早晚各一次,服用的时间20天一个疗程。
效果跟踪:
经三藤醒脑汤剂治疗2个疗程后,血压血脂指标均正常,头痛减轻,皮肤有光泽,紧致细腻,睡眠好,精力充沛,头疼、头晕、脑鸣症状消失,记忆力明显增强。
实施例3
(1)按以下重量份数取各原料药:
海风藤20 大血藤 40 青风藤20
丹参 20 丹皮12 三七5
柴胡12 郁金12 红花8
桃仁12 当归12 金蝎子 12
蜈蚣12 陈皮12 砂仁25
生薏仁35 泽泻 15 天麻12 ;
将以上的原料药粉碎至100目,得原料药粉;
(2)将以上的原料药粉制成胶囊,得胶囊制剂的三藤醒脑药物制剂。
治疗老年痴呆案例
宋某,女,68岁。家族遗传性老年痴呆,60岁以后记忆力明显下降,经常忘事,近一年逐渐出现麻木,不认识人等加重症状,表情木讷,语言减少,影响生活质量。
用法用量:
每次服用胶囊10克,每日2次,早晚各一次,服用的时间20天一个疗程;每10克药物中有效原料生药为 11 克。
效果跟踪:经过三藤醒脑丸治疗后,记忆力明显进步,语言增多,思维清晰,忘事现象减轻,不认识人的症状消失,思维明显活跃。
Claims (10)
1.三藤醒脑组合物,其特征在于,所述的醒脑组合物主要包括海风藤、大血藤、青风藤。
2.如权利要求1所述的三藤醒脑组合物,其特征在于,三藤醒脑组合物是包括海风藤、大血藤、青风藤的提取物。
3.如权利要求1所述的三藤醒脑组合物,其特征在于,三藤醒脑组合物是包括海风藤、大血藤、青风藤、丹参、丹皮、三七、柴胡、郁金、红花、桃仁、当归、金蝎子、蜈蚣、陈皮、砂仁、生薏仁、泽泻、天麻的提取物。
4.如权利要求3所述的三藤醒脑组合物,其特征在于,其中的提取是用水煎煮提取,水煎煮提取的次数是3次。
5.如权利要求1所述的三藤醒脑组合物,其特征在于,所述的三藤醒脑组合物包括下述重量份数的原料:
海风藤10-20 大血藤 20-40 青风藤10-20
丹参 10-20 丹皮8-12 三七1-5
柴胡8-12 郁金8-12 红花4-8
桃仁8-12 当归8-12 金蝎子 8-12
蜈蚣8-12 陈皮8-12 砂仁15-25
生薏仁25-35 泽泻 5-15 天麻8-12 。
6.如权利要求1所述的三藤醒脑组合物,其特征在于,所述的三藤醒脑组合物包括下述重量份数的原料:
海风藤15 大血藤 30 青风藤15
丹参 15 丹皮10 三七3
柴胡10 郁金10 红花 6
桃仁10 当归10 金蝎子 10
蜈蚣10 陈皮12 砂仁20
生薏仁30 泽泻 10 天麻10 。
7.三藤醒脑药物制剂,其特征在于,包括权利要求1-6中任意一项所述的三藤醒脑组合物和药学上可接受的辅料。
8.如权利要求7中所述的三藤醒脑药物制剂,该制剂为片剂、胶囊剂、丸剂、汤剂中的任一种。
9.如权利要求8所述的三藤醒脑药物制剂,其特征在于,三藤醒脑药物制剂为丸剂,该丸剂的制备方法如下:
(1)取以下的原料:10-20份海风藤、20-40份大血藤、10-20份青风藤、10-20份丹参、8-12份丹皮、1-5份三七、8-12份柴胡、8-12份郁金、4-8份红花、8-12份桃仁、8-12份当归、8-12份金蝎子、8-12份蜈蚣、8-12份陈皮、15-25份砂仁、25-35份生薏仁、5-15份泽泻、8-12份天麻,粉碎,混匀,得原料药粉;
(2)在上述的粉碎的原料药粉中加入水或/和蜂蜜,调成糊状;
(3)采用压丸机制成丸剂,即得。
10.如权利要求1-6中任一项的中药组合物和/或权利要求8-9中任一项的药物制剂,在治疗脑血管供血不足、神经***疾病、抗衰老、糖尿病、疲劳综合症、老年痴呆症中的应用。
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