CN106692191A - Wound surface protection composition and preparation method thereof - Google Patents
Wound surface protection composition and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a wound surface protection composition and a preparation method thereof. The wound surface protection composition is prepared from the following raw materials in percentage by mass: 1 to 5 percent of thickening agent, 1 to 40 percent of moisturizing agent, 0.1 to 2 percent of antibacterial agent and the balance of seawater filter liquor. An experiment verifies that the wound surface protection composition can be specifically used for a wound surface in a scar dissolving period, secretion of neutrophil protease can be effectively promoted, the falling of necrotic tissues is further quickened, scar dissolving is quickened, a wound can be effectively cleaned and disinfected, infection can be inhibited, and the wound healing is promoted; a preparation technology is simple, and the cost is low.
Description
Technical field
The invention belongs to biomedicine technical field, more particularly to a kind of protecting wound surface composition and preparation method thereof.
Background technology
Wound repair is that body response damages a showed biological process for complexity, mainly includes that local inflammation is anti-
Answer stage, cell proliferation and differentiation stage and tissue reconstruction stage.The change of local microenvironment, including wound locally various cells,
The interaction of extracellular matrix and growth factor etc., has significant effect to wound healing.
Ocean is the cradle of life, and seawater is not only the water resource of preciousness, and the chemical resource that is richly stored with.China
It is a marine resources big country, possesses exploitation ocean, the advantage of extensive development blueness industry.The technology bar of seawater utilization
Part is also mature on the whole, and also external advanced experience can be used for reference, and seawater is a kind of extremely complex multicomponent aqueous solution.
Composition in seawater is very complicated, can be largely classified into five classes：1. main component (a large amount of, macroelement) is 2. dissolved in sea
The nutrient of gas componant 3. (nutritive salt, bioactive elemements) of water：Key element mainly relevant with sea-plant growth, typically
Refer to N, P and Si etc..4. micro-：Content is very low in the seawater, but the person that is not belonging to nutrient.5. the organic matter in seawater
Matter：Such as amino acid, humus, chlorophyll.
Compared with abundant marine resources, the seawater resources utilization rate of China is then relatively low, although marine resources are in sea
Water desalination, marine mining, seawater energy etc. are utilized above significant progress, but, seawater resources should biomedicine field
With relatively fewer.
The content of the invention
The purpose of the present invention is to overcome the deficiencies in the prior art, there is provided after a kind of wound enters inflammatory phase, can be effectively molten
Scab, the protecting wound surface composition of anti-infective wound healing.
Second object of the present invention is to provide a kind of preparation method of protecting wound surface composition.
Technical scheme is summarized as follows：
Protecting wound surface composition, by mass percentage by thickener 1%-5%, NMF 1%-40%, antiseptic 0.01-
2%th, balance of seawater filtrate composition.
Preferably, the thickener is that 2%-3%, NMF are that 10%-30%, antiseptic are by mass percentage
0.01%-1%, balance of seawater filtrate.
Thickener is xanthans, Sodium Hyaluronate, guar gum, Sodium Polyacrylate, Carbomer, gelatin, pectin, carboxymethyl
Cellulose or sodium carboxymethylcellulose；The NMF is 1.3- propane diols or 1,3 butylene glycol.
Antiseptic is sodium tetraborate, polyhexamethylene guanide, polylysine, benzalkonium bromide, the salt of silver ion.
Seawater filtrate is obtained with following steps：Take and meet《GB3097-1997》The seawater of the middle first kind, uses 120 mesh successively
Be sieved through filter, through obtaining seawater filtrate after 0.45 μm of PES filtering with microporous membrane, 0.2 μm of PES filtering with microporous membrane.
The preparation method of protecting wound surface composition, comprises the following steps：
(1) thickener 1%-5%, NMF 1%-40%, antiseptic 0.01-2%, balance of is weighed by mass percentage
Seawater filtrate；
(2) NMF is added in water phase tank, is heated with stirring to 70-80 DEG C, add antiseptic, stir 20-30min；
(3) emulsion tank is first heated to 70-80 DEG C, the mixture that step (2) is obtained is pumped into emulsion tank, will thickened
Agent is added in emulsion tank, homogeneous stirring 300-400s；Seawater filtrate is added, homogeneous stirring 300-400s is 15- in rotating speed
20-30min is stirred under the conditions of 25r/min；
(4) normal temperature is cooled to, is obtained final product.
Step (1) is preferably：Thickener 2%-3%, NMF 10%-30%, antiseptic are weighed by mass percentage
0.01%-1%, balance of seawater filtrate.
The thickener is xanthans, Sodium Hyaluronate, guar gum, Sodium Polyacrylate, Carbomer, pectin, gelatin, carboxylic
Methylcellulose or sodium carboxymethylcellulose；The NMF is 1.3- propane diols or 1,3 butylene glycol.
The antiseptic is sodium tetraborate, polyhexamethylene guanide, polylysine, benzalkonium bromide, the salt of silver ion.
The seawater filtrate is obtained with following steps：Take and meet《GB3097-1997》The seawater of the middle first kind, uses successively
120 mesh screens, through obtaining seawater filtrate after 0.45 μm of PES filtering with microporous membrane, 0.2 μm of PES filtering with microporous membrane.
Advantages of the present invention：
Experiment proves that composition of the invention non-specific can be used for the molten scab phase surface of a wound, can effectively facilitate neutral grain
The secretion of leukoprotease, and then accelerate coming off for slough, accelerate molten scab, cleaning sterilizing effectively can be carried out to affected part and disappeared
Poison, suppresses infection, wound healing.Preparation process is simple, low cost.
Specific embodiment
With reference to specific embodiment, the present invention is further illustrated, in the examples below the salt of silver ion with
As a example by flamazine.
Table 1：The raw material proportioning (quality %) of the composition of the protecting wound surface of embodiment 1--- embodiments 6
Embodiment 10
The seawater filtrate of each embodiment is obtained with following steps：
Take and meet《GB3097-1997》The seawater of the middle first kind, successively with 120 mesh screens, through 0.45 μm of PES micropore
Seawater filtrate is obtained after membrane filtration, 0.2 μm of PES filtering with microporous membrane.
Embodiment 11
A kind of preparation method of protecting wound surface composition, comprises the following steps：
(1) each component in embodiment 1 is weighed by mass percentage；
(2) NMF is added in water phase tank, is heated with stirring to 70 DEG C, add antiseptic, stir 30min；
(3) emulsion tank is first heated to 70 DEG C, the mixture that step (2) is obtained is pumped into emulsion tank, by thickener
It is added in emulsion tank, homogeneous stirring 400s；Seawater filtrate is added, homogeneous stirring 300 is stirred under the conditions of rotating speed is 25r/min
Mix 20min；
(4) normal temperature is cooled to, is obtained final product.
Embodiment 12
A kind of preparation method of protecting wound surface composition, comprises the following steps：
(1) each component in embodiment 2 is weighed by mass percentage；
(2) NMF is added in water phase tank, is heated with stirring to 80 DEG C, add antiseptic, stir 20min；
(3) emulsion tank is first heated to 80 DEG C, the mixture that step (2) is obtained is pumped into emulsion tank, by thickener
It is added in emulsion tank, homogeneous stirring 300s；Seawater filtrate is added, homogeneous stirring 400s is stirred under the conditions of rotating speed is 15r/min
Mix 30min；
(4) normal temperature is cooled to, is obtained final product.
Embodiment 13
A kind of preparation method of protecting wound surface composition, comprises the following steps：
(1) each component in embodiment 3 is weighed by mass percentage；
(2) NMF is added in water phase tank, is heated with stirring to 75 DEG C, add antiseptic, stir 25min；
(3) emulsion tank is first heated to 75 DEG C, the mixture that step (2) is obtained is pumped into emulsion tank, by thickener
It is added in emulsion tank, homogeneous stirring 350s；Seawater filtrate is added, homogeneous stirring 350s is stirred under the conditions of rotating speed is 20r/min
Mix 25min；
(4) normal temperature is cooled to, is obtained final product.
Embodiment 14
A kind of preparation method of protecting wound surface composition, comprises the following steps：
(1) each component in embodiment 4 is weighed by mass percentage；
(2) NMF is added in water phase tank, is heated with stirring to 70 DEG C, add antiseptic, stir 23min；
(3) emulsion tank is first heated to 70 DEG C, the mixture that step (2) is obtained is pumped into emulsion tank, by thickener
It is added in emulsion tank, homogeneous stirring 370s；Seawater filtrate is added, homogeneous stirring 320s is stirred under the conditions of rotating speed is 20r/min
Mix 25min；
(4) normal temperature is cooled to, is obtained final product.
Embodiment 15
A kind of preparation method of protecting wound surface composition, comprises the following steps：
(1) each component in embodiment 5 is weighed by mass percentage；
(2) NMF is added in water phase tank, is heated with stirring to 80 DEG C, add antiseptic, stir 30min；
(3) emulsion tank is first heated to 80 DEG C, the mixture that step (2) is obtained is pumped into emulsion tank, by thickener
It is added in emulsion tank, homogeneous stirring 300s；Seawater filtrate is added, homogeneous stirring 400s is stirred under the conditions of rotating speed is 25r/min
Mix 30min；
(4) normal temperature is cooled to, is obtained final product.
Embodiment 16
A kind of preparation method of protecting wound surface composition, comprises the following steps：
(1) each component in embodiment 6 is weighed by mass percentage；
(2) NMF is added in water phase tank, is heated with stirring to 80 DEG C, add antiseptic, stir 25min；
(3) emulsion tank is first heated to 80 DEG C, the mixture that step (2) is obtained is pumped into emulsion tank, by thickener
It is added in emulsion tank, homogeneous stirring 350s；Seawater filtrate is added, homogeneous stirring 350s is stirred under the conditions of rotating speed is 20r/min
Mix 25min；
(4) normal temperature is cooled to, is obtained final product.
Embodiment 17
A kind of preparation method of protecting wound surface composition, comprises the following steps：
(1) each component in embodiment 7 is weighed by mass percentage；
(2) NMF is added in water phase tank, is heated with stirring to 75 DEG C, add antiseptic, stir 20min；
(3) emulsion tank is first heated to 75 DEG C, the mixture that step (2) is obtained is pumped into emulsion tank, by thickener
It is added in emulsion tank, homogeneous stirring 300s；Seawater filtrate is added, homogeneous stirring 400s is stirred under the conditions of rotating speed is 20r/min
Mix 25min；
(4) normal temperature is cooled to, is obtained final product.
Embodiment 18
A kind of preparation method of protecting wound surface composition, comprises the following steps：
(1) each component in embodiment 8 is weighed by mass percentage；
(2) NMF is added in water phase tank, is heated with stirring to 70 DEG C, add antiseptic, stir 25min；
(3) emulsion tank is first heated to 80 DEG C, the mixture that step (2) is obtained is pumped into emulsion tank, by thickener
It is added in emulsion tank, homogeneous stirring 300s；Seawater filtrate is added, homogeneous stirring 350s is stirred under the conditions of rotating speed is 20r/min
Mix 25min；
(4) normal temperature is cooled to, is obtained final product.
Embodiment 19
A kind of preparation method of protecting wound surface composition, comprises the following steps：
(1) each component in embodiment 9 is weighed by mass percentage；
(2) NMF is added in water phase tank, is heated with stirring to 80 DEG C, add antiseptic, stir 20min；
(3) emulsion tank is first heated to 70 DEG C, the mixture that step (2) is obtained is pumped into emulsion tank, by thickener
It is added in emulsion tank, homogeneous stirring 400s；Seawater filtrate is added, homogeneous stirring 300s is stirred under the conditions of rotating speed is 25r/min
Mix 25min；
(4) normal temperature is cooled to, is obtained final product.
Embodiment 20
According to document, four kinds of surface of a wound common bacterias of selection are used as experimental bacteria for Experiment on Microbiology：MRSE, large intestine angstrom are wished
Bacterium, staphylococcus aureus, Pseudomonas aeruginosa (four kinds of bacterium are purchased from Tianjin medicine inspecting institute).
Protecting wound surface composition, sodium tetraborate of the experimental technique to embodiment 11-19 described in foundation GB2738-2012
(mass concentration is that 1.4% polyhexamethylene guanide is water-soluble for (mass concentration is the 1.05% sodium tetraborate aqueous solution), polyhexamethylene guanide
Liquid), benzalkonium bromide (mass concentration be the 0.01% benzalkonium bromide aqueous solution), (mass concentration is that 0.8% sulfanilamide (SN) is phonetic to flamazine
The pyridine silver aqueous solution), polylysine (mass concentration be the 2% polylysine aqueous solution) do antibacterial, bacteriostatic experiment.
Antibacterial：Bacterium is killed using chemically or physically method or the process of bacterial growth breeding and its activity is hindered.It is antibacterial：
Suppress or hinder the process of bacterial growth breeding and activity using chemically or physically method.
Table 2, antibacterial effect (time：1.5h)
| MRSE | EHEC | Staphylococcus aureus | Pseudomonas aeruginosa | |
| Embodiment 11 | 86.35%△ | 78.26%△ | 97.98%△ | 71.68%△ |
| Embodiment 12 | 87.21%△ | 79.36%△ | 98.67%△ | 70.29%△ |
| Embodiment 13 | 86.29%△ | 80.35%△ | 97.46%△ | 71.37%△ |
| Embodiment 14 | 86.95%△ | 81.27%△ | 98.35%△ | 71.06%△ |
| Embodiment 15 | 87.39%△ | 80.39%△ | 99.14%△ | 70.68%△ |
| Embodiment 16 | 88.15%△ | 82.51%△ | 100%△ | 73.51%△ |
| Embodiment 17 | 87.39% | 79.62% | 99.34% | 69.35% |
| Embodiment 18 | 85.91% | 80.29% | 98.91% | 71.58% |
| Embodiment 19 | 86.43% | 79.80% | 98.75% | 72.08% |
| Polyhexamethylene guanide | 42.19% | 41.39% | 59.81% | 32.68% |
| Sodium tetraborate | 35.93% | 29.68% | 38.69% | 40.49% |
| Benzalkonium bromide | 58.61% | 42.69% | 69.28% | 41.36% |
| Flamazine | 61.39% | 49.68% | 72.64% | 50.15% |
| Polylysine | 59.68% | 43.28% | 63.38% | 47.24% |
△ is with flamazine group than P ＜ 0.05
Experimental result, in antiseptic, different antiseptics show different antibiotic properties to different strains, and implement
The composition of example 11-19 has antibiotic property to different strain and has significant difference.
Table 3, fungistatic effect (time：1.5h)
| MRSE | EHEC | Staphylococcus aureus | Pseudomonas aeruginosa | |
| Embodiment 11 | 84.85%△ | 79.16%△ | 96.29%△ | 69.35%△ |
| Embodiment 12 | 84.29%△ | 79.52%△ | 97.05%△ | 69.66%△ |
| Embodiment 13 | 85.17%△ | 78.74%△ | 96.34%△ | 68.59%△ |
| Embodiment 14 | 85.02%△ | 78.65%△ | 96.58%△ | 68.94%△ |
| Embodiment 15 | 85.09%△ | 78.62%△ | 97.64%△ | 67.29%△ |
| Embodiment 16 | 86.39%△ | 80.36%△ | 98.26%△ | 70.26%△ |
| Embodiment 17 | 84.39% | 76.35% | 95.02% | 69.34% |
| Embodiment 18 | 85.27% | 78.95% | 96.31% | 68.04% |
| Embodiment 19 | 85.59% | 79.05% | 95.80% | 68.17% |
| Polyhexamethylene guanide | 28.95% | 39.62% | 70.26% | 29.43% |
| Sodium tetraborate | 39.46% | 30.05% | 52.61% | 35.61% |
| Benzalkonium bromide | 39.12% | 40.28% | 56.39% | 40.39% |
| Flamazine | 48.66% | 48.38% | 62.39% | 45.39% |
| Polylysine | 45.28% | 43.65% | 55.85% | 38.41% |
△ is with flamazine than P ＜ 0.05
Experimental result, in antiseptic, different antiseptics show different biocidal properties to different strains, and implement
The composition of example 11-19 has biocidal property to different strain and has significant difference.
Embodiment 21
Cleaning grade SD rats 90,8-10 week old, body weight 230-260g, male, purchased from Beijing China Fukang biotechnology stock
Part Co., Ltd, adaptability is raised one week, ad lib, drinking-water.
Rat 3% yellow Jackets (50mg/kg) intraperitoneal injection of anesthesia.After anesthesia onset, back hair cutter shaving,
Preserved skin area is cleaned after barium sulphide depilation, with twice of iodine tincture disinfection, is made in rat back with Constant Temp. Oven (75 DEG C, 8s)
The circular deep ii degree burn surface of a wound of 3*3cm.
SD rats 90 are only randomly divided into control group (polyurethane hydrogel burn dressing, Soviet Union food medicine prison tool (standard) word 2,013 the
No. 2641260), 11 groups of embodiment, 12 groups of embodiment, 13 groups of embodiment, 14 groups of embodiment, 15 groups of embodiment, 16 groups of embodiment,
17 groups of embodiment, 18 groups of embodiment, 19 groups of embodiment.
Visually observe：The molten scab situation of each group before and after the 1st, 3,5,7,10,14 days observation burns after making wound, it is completely molten
The scab time.It is shown in Table 4
The measure of neutrophil elastase：Take each group at random within the 1st, 3,5,7,10,14 days after the surface of a wound is formed
Animal, using neutrophil elastase in EUSA (ELISA method) measure wound tissue.
Neutrophil elastase is the important protease of neutrophil leucocyte secretion, belongs to the gruel of serine protease
Superfamily protein member, it can decompose nearly all extracellular matrix and many important plasma proteins, it is considered to be most
One of enzyme albumen of destructive power.Neutrophil elastase has defence tissue damage, promotees secretion, amplifies inflammation simultaneously
Deng effect, increasing for neutrophil elastase has been pointed out the activity of neutrophil leucocyte and has been promoted to the molten of slough
Solution.Accelerate coming off and to the phylactic power defensive power of invasion bacterium for local necrosis tissue, promote the autolyzed debridement of body, raising is local to exempt from
Epidemic disease power is with anti-infective.It is shown in Table 5.
Wound healing rate：Using transparent graph paper, surface of a wound size shape is traced at eye sore face crust edge, with crust before medication
Area is dehumidification area, records each group surface of a wound crust area respectively daily later, after being scanned through computer, using Photoshop
Carry out calculating the molten scab rate of the surface of a wound with Osiris softwares.Computing formula：Wound healing rate=(the initial crust area-surface of a wound shape of the surface of a wound
Surface of a wound crust area into latter n-th day) the initial crust area * 100% of/surface of a wound.It is shown in Table 6.
Visually observe：The equal surface of a wound of each group rat molten scab since burnt degree 3 days, crust gradually softens after topical agent,
Edge is tilted, and crust is progressively reduced until with the ribbon that base links and is kept completely separate, and in monoblock and block separation more than crust, is gone
Base barrier after scab and with blutpunkte.From burnt degree 5 days, each group started to show molten scab speed difference.
The molten scab time (unit of table 4：My god)：
| Group | Time | Group | Time |
| 11 groups of embodiment | 10.29±2.68△ | 16 groups of embodiment | 10.06±2.17△ |
| 12 groups of embodiment | 10.28±2.71△ | 17 groups of embodiment | 10.98±2.48△ |
| 13 groups of embodiment | 10.31±2.83△ | 18 groups of embodiment | 11.00±2.39△ |
| 14 groups of embodiment | 10.68±2.57△ | 19 groups of embodiment | 10.85±2.17△ |
| 15 groups of embodiment | 10.20±2.53△ | Control group | 13.29±2.81△ |
△ P compared with control group<0.01
The measure of the wound tissue neutrophil elastase of table 5：
△ P compared with control group<0.01
Table 6, Wound healing rate：
△ P compared with control group<0.01
Specific embodiment of the invention is only expressed with above-described embodiment, its description is more specific and detailed, but not
Therefore the limitation to the scope of the claims of the present invention can be interpreted as.It should be pointed out that coming for one of ordinary skill in the art
Say, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Scope.
Claims (10)
1. protecting wound surface composition, it is characterized in that by mass percentage by thickener 1%-5%, NMF 1%-40%, antibacterial
Agent 0.01-2%, balance of seawater filtrate composition.
2. protecting wound surface composition according to claim 1, it is characterized in that the thickener is 2%- by mass percentage
3%th, NMF be 10%-30%, antiseptic be 0.01%-1%, balance of seawater filtrate.
3. protecting wound surface composition according to claim 1 and 2, it is characterized in that the thickener is xanthans, hyalomitome
Sour sodium, guar gum, Sodium Polyacrylate, Carbomer, gelatin, pectin, carboxymethylcellulose calcium or sodium carboxymethylcellulose；The guarantor
Humectant is 1.3- propane diols or 1,3 butylene glycol.
4. protecting wound surface composition according to claim 1 and 2, it is characterized in that the antiseptic is sodium tetraborate, poly- six
The salt of methylene guanidine, polylysine, benzalkonium bromide or silver ion.
5. protecting wound surface composition according to claim 1 and 2, it is characterized in that the seawater filtrate uses following steps system
：Take and meet《GB3097-1997》The seawater of the middle first kind, successively with 120 mesh screens, through 0.45 μm of PES miillpore filter
Seawater filtrate is obtained after filtering, 0.2 μm of PES filtering with microporous membrane.
6. the preparation method of protecting wound surface composition, its feature comprises the following steps：
(1) thickener 1%-5%, NMF 1%-40%, antiseptic 0.01-2%, balance of seawater are weighed by mass percentage
Filtrate；
(2) NMF is added in water phase tank, is heated with stirring to 70-80 DEG C, add antiseptic, stir 20-30min；
(3) emulsion tank is first heated to 70-80 DEG C, the mixture that step (2) is obtained is pumped into emulsion tank, by thickener plus
Enter in emulsion tank, homogeneous stirring 300-400s；Seawater filtrate is added, homogeneous stirring 300-400s is 15-25r/ in rotating speed
20-30min is stirred under the conditions of min；
(4) normal temperature is cooled to, is obtained final product.
7. method according to claim 6, it is characterized in that the step (1) is：Thickener is weighed by mass percentage
2%-3%, NMF 10%-30%, antiseptic 0.01%-1%, balance of seawater filtrate.
8. the method according to claim 6 or 7, it is characterized in that the thickener is xanthans, Sodium Hyaluronate, cluster bean
Glue, Sodium Polyacrylate, Carbomer, pectin, gelatin, carboxymethylcellulose calcium or sodium carboxymethylcellulose；The NMF is 1.3-
Propane diols or 1,3 butylene glycol.
9. the method according to claim 6 or 7, it is characterized in that the antiseptic is sodium tetraborate, polyhexamethylene guanide, poly-
The salt of lysine, benzalkonium bromide or silver ion.
10. the method according to claim 6 or 7, it is characterized in that the seawater filtrate is obtained with following steps：Take and meet
《GB3097-1997》The seawater of the middle first kind, successively with 120 mesh screens, through 0.45 μm of PES filtering with microporous membrane, 0.2 μm
PES filtering with microporous membrane after obtain seawater filtrate.
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| CN110507603A (en) * | 2019-09-12 | 2019-11-29 | 沈阳大得医疗器械产品有限公司 | A kind of solidification seawater gel and preparation method thereof |
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