CN106667430A - Nano-reinforced functional blood oxygen imaging diagnosing and treating system for breast tumor and application thereof - Google Patents
Nano-reinforced functional blood oxygen imaging diagnosing and treating system for breast tumor and application thereof Download PDFInfo
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- CN106667430A CN106667430A CN201510764927.7A CN201510764927A CN106667430A CN 106667430 A CN106667430 A CN 106667430A CN 201510764927 A CN201510764927 A CN 201510764927A CN 106667430 A CN106667430 A CN 106667430A
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Abstract
The invention discloses to a nano-reinforced functional blood oxygen imaging diagnosing and treating system for the breast tumor and application thereof. The nano-reinforced functional blood oxygen imaging diagnosing and treating system comprises a main control computer, an equipment controller, an infrared imaging module, an infrared ray generating module and a photodynamic treating module. The main control computer is connected with the equipment controller through a serial bus. The equipment controller is connected with the photodynamic treating module and the infrared ray generating module respectively. The infrared imaging module is connected with the main control computer. As an instrument for the breast tumor, the nano-reinforced functional blood oxygen imaging diagnosing and treating system for the breast tumor combines a diagnosing technology and a treating technology, and by applying the instrument, nano-targeted noninvasive photodynamic therapy and visible nano-targeted photosensitizer detection and diagnosis can be achieved respectively, a breast tumor diagnosing and treating instrument with double functions including diagnosing and treating is developed, and functions of functional breast blood oxygen imaging, nano-reinforced breast blood oxygen imaging, non-invasive breast blood oxygen detecting and nano-reinforced noninvasive photodynamic therapizing for the breast tumor are achieved.
Description
Technical field
The present invention relates to medical field, more particularly to a kind of breast tumor blood oxygen nanometer strengthens functional image Clinics and Practices system and its application.
Background technology
According to investigation statisticses, China suffers from breast cancer more than up to 210,000 people every year, 20 years old in advance ill age, ill rejuvenation.Because early symptom is not obvious and ignored, more than 85% patient causes the mortality rate of breast carcinoma to rise year by year to middle and advanced stage has been arrived during examination in hospital, has become the number one killer for threatening women life.In the face of such a situation, how comprehensive breast screening activity is carried out to women using the medical instruments and equipment of high end advanced, it is the task of top priority that early discovery, early treatment are tried hard to be to breast carcinoma, and this is the important measures resisted breast carcinoma, protect breast, reduce relapse rate and mortality rate.Existing breast examination with means be with molybdenum target, ultrasound based on.Although in breast screening, both inspection methods have the local superiority of oneself, also receive certain limitation, such as：Molybdenum target is sensitive to calcification, but the body of gland type mammary gland level to Nails differentiates inadequate, has ray, belongs to invasive inspection, is unfit to do health check-up examination use.Occupy-place reflection of the ultrasound to capsule and reality is sensitive but higher to Doctors' skill level requirement, checks that speed is slower, and unsuitable extensive health check-up examination is used.The special magnetic resonance of mammary gland, it is possible to find the tiny pathological changes of 0. 3cm or so, can check that physical palpation gathers around the impalpable tumor nodule of handss, measurement in space can be carried out simultaneously, functional diagnosis, greatly improves accuracy rate of diagnosis, makes mammary cancer radical operation protect the advanced level that newborn rate reaches 60%-70%.But its expensive price is unfavorable for the generaI investigation application of clinical basic unit.
Domestic patent database disclosed some related patented technologies in recent years：
Such as patent CN2005100979817, a kind of mammary gland blood-oxygen functional imaging method and mammary gland blood-oxygen functional imaging system, the invention using double-wavelength light source irradiate mammary gland tissue, after with detector receive light intensity；Again the light intensity is switched to switch to Digital Signal Processing after analogue signal again, by post processing of image, calculate oxygen conjunction, deoxyhemoglobin variable quantity；Finally oxygen is closed, deoxyhemoglobin variable quantity is mapped to as generating figure；The system features are：Include dual wavelength generator and computer assisted image processing system；Wherein dual wavelength generator is connected with described light source control module, and computer assisted image processing system is connected with described computer central processing system.It is abundant, true, accurate and effective using the view data acquired in the method and system, good precondition is provided to carry out post processing to scan-image using computer.After the system increases image digitization technology, post-processing technology and blood oxygen analysis technology, diagnostic accordance rate is improve.
And for example patent CN 2010201208023, double light source dual probe mammary gland blood-oxygen functional imaging systems, the utility model are related to a kind of pair of light source dual probe mammary gland blood-oxygen functional imaging system, including：Double-wavelength light source, double detector, blood oxygen and three ways of calculating subsignal collecting unit, computer and mammary gland information analysiss processing system, it is characterised in that：In double detector, two outfan Jing video lines are connected with an input of two inputs and three ways of calculating subimage capture card of the blood oxygen image pick-up card in blood oxygen and three ways of calculating subsignal collecting unit respectively, and three outfans of blood oxygen and three ways of calculating subsignal collecting unit are connected with computer and mammary gland information analysiss processing system respectively.The utility model provides a kind of pair of light source dual probe mammary gland blood-oxygen functional imaging system, provides a kind of efficient and convenient, practical, efficient breast image diagnostic device for diagnosis.
But system above is the new diagnostic equipment of rapid screening early-stage breast cancer and various mastopathy, without the function of reaching treatment.
The content of the invention
Present invention aim to overcome that the deficiencies in the prior art, there is provided one kind makes Multifunctional galactophore blood-oxygen functional imaging system and near infrared light, nano target Imaging enhanced combine with optical dynamic therapy, comprehensively better than it is existing for breast examination and treatment system, effectively improve the early diagnosiss accuracy rate and therapeutic effect of breast tumor, improve and protect newborn rate, and the effect that Clinics and Practices technology combines can be reached.
To achieve these goals, present invention employs technical scheme below：
A kind of breast tumor blood oxygen nanometer strengthens functional image Clinics and Practices system and its application, including main control computer, device controller, infrared imaging module, infrared ray occur module and optical dynamic therapy module；The main control computer is connected by universal serial bus with device controller；There is module with optical dynamic therapy module, infrared ray respectively and be connected in the device controller；The infrared imaging module is connected with main control computer by bus.
The main control computer provide user interface, the input of information, result output display and printing, galactophore image analysis and process, and the communication of device controller and the data analysiss of system with process.
The device controller plays a part of a kind of gateway between main control computer and modules, equipment control is connected with computer by RS232 buses, it is responsible for receiving the control command and data from computer, and according to the order for being received, modules are controlled, the state and data of modules are read simultaneously, are then transferred to main control computer.Avoid modules to be directly directly connected to main control computer and cause line complicated and increase the burden of main control computer.
Further, the infrared imaging module is provided with image pick-up card, the infrared CCD photographic head being sequentially connected.The function of infrared imaging module is to gather the blood flow blood oxygen of lesion and be colored tumor tissues image, is then passed to main control computer and is analyzed and processes.
Further, the infrared CCD photographic head is provided with infrared fileter so that acquired image is not disturbed by extraneous visible ray, reduces background noise.
Further, the infrared ray generation module is provided with the infrared line drive circuit and infrared emitting probe being sequentially connected.The function of infrared line drive circuit and infrared emitting probe is under the control of device controller, produce the infrared drive signal of characteristic frequency and pulsewidth, infrared emitting probe is driven to produce the infrared light of certain power and wavelength, and treatment target corresponding site is irradiated to, infrared image acquisition being carried out for infrared CCD photographic head, necessary light source is provided.
Further, the photodynamic therapy system is provided with the drive circuit and optical dynamic therapy probe being sequentially connected.Popped one's head in by optical dynamic therapy and produce the HONGGUANG or near infrared light of specific wavelength and certain power, irradiation is targeted nanometer liposome and dyes glaucous tumor tissues or tumor cell, and photodynamic reaction can be produced after the light energy of the sensitiser absorption in tumor tissues or tumor cell to the wavelength（Photochemical reaction）Generate the very strong singlet oxygen of activity and（Or）There is oxidation reaction in free radical, singlet oxygen and various biomacromolecules, and be brought rapidly up to certain temperature killing tumor cell, and normal histiocyte be had no toxic side effect and noinvasive damage.
Described targeted nano tumor staining agent is the nanoparticle that a kind of micromolecule polypeptide for having targeting to breast carcinoma is targeting agent; oxygenation agent, photosensitizer are carried simultaneously; internal targeting breast tissues are entered by local injection or the approach such as oral; targeted nano granule can automatic tracking of knub tissue or tumor cell; and combine with its surface receptor, tumor tissues or tumor cell are coloured to into the aeruginouss tissue of Glassless（And normal structure does not absorb stain）Increase the blood oxygen concentration of focus local simultaneously, photosensitizer is enriched with lesion region, obtain the high-resolution imaging of lesion, and while the wavelength HONGGUANG that sent using photodynamic therapy system or near infrared light, irradiation tumor tissues or tumor cell, can produce photodynamic reaction after the light energy of the sensitiser absorption in tumor tissues or tumor cell to the wavelength（Photochemical reaction）Generate the very strong singlet oxygen of activity and（Or）There is oxidation reaction in free radical, singlet oxygen and various biomacromolecules, and be brought rapidly up killing tumor cell to certain temperature, realize AT optical dynamic therapy.
Further, the diagnosis and therapy system also includes infrared temperature detecting module, and the infrared temperature detecting module is connected with device controller.The function of infrared temperature detecting module is that the temperature to target area carries out real-time monitoring, and feed back to device controller and main control computer, reference data is provided for optical dynamic therapy module output, is made to better control over the output of optical dynamic therapy module, is improved therapeutic effect.
The breast tumor blood oxygen nanometer strengthens functional image Clinics and Practices system, is applied to the Clinics and Practices of breast tumor.
Operation principle of the present invention：
Targeted nano tumor staining agent local injection or the approach such as oral are entered internal targeting breast tissues, simultaneously, there is module under the control of device controller in infrared ray, by arranging the infrared drive signal for producing characteristic frequency and pulsewidth, drive infrared emitting probe to produce the infrared light of certain power and specific wavelength, and be irradiated to treatment target corresponding site；Then, the blood flow of infrared imaging module collection treatment target specific region, blood oxygen and the tumor tissues image being colored, then feed back to main control computer and are analyzed and process；Further according to the analyzing and diagnosing result of main control computer, the HONGGUANG or near infrared light that optical dynamic therapy module produces specific wavelength and power is controlled by device controller, the HONGGUANG sent by light dynamical system or near infrared light tumor tissues or tumor cell, can produce photodynamic reaction after the light energy of the sensitiser absorption in tumor tissues or tumor cell to the wavelength（Photochemical reaction）Generate the very strong singlet oxygen of activity and（Or）There is oxidation reaction in free radical, singlet oxygen and various biomacromolecules, and be brought rapidly up to certain temperature, and kill tumor cell, reach therapeutic purposes；Simultaneously, infrared temperature detecting module carries out real-time monitoring to the temperature of target area, and feeds back to device controller and main control computer, provides reference data for optical dynamic therapy module output, make to better control over optical dynamic therapy module output, improve therapeutic effect.
Beneficial effects of the present invention：
（1）The present invention adopts visual nano target technology, using the automatic targeting tumor tissues of nanoparticle, blood-oxygen functional Enhanced Imaging is capable of achieving, optical dynamic therapy can be produced again under infrared ray action and killed tumor tissues and removed remaining zero tumor cell, reduce omitting probability, improve Clinics and Practices effect.
（2）The present invention is acquired process to the tumor image of tracer radiography, clearly displays wheel hub and region and the border of tumor, and the operation treatment for healthcare givers provides effectively guiding.
Description of the drawings
Fig. 1 is the structural representation of the present invention.
Specific embodiment
The present invention is further described with reference to the accompanying drawings and examples, but protection scope of the present invention is not limited solely to following examples.
Embodiment 1
A kind of breast tumor blood oxygen nanometer strengthens functional image Clinics and Practices system, including main control computer, device controller, infrared imaging module, infrared ray occur module and optical dynamic therapy module；The main control computer is connected by universal serial bus with device controller；There is module with optical dynamic therapy module, infrared ray respectively and be connected in the device controller；The infrared imaging module is connected with main control computer by bus.
The infrared imaging module is provided with image pick-up card, the infrared CCD photographic head being sequentially connected.The infrared line drive circuit and infrared emitting probe being sequentially connected be provided with and module in the infrared ray there is.The optical dynamic therapy module is provided with the drive circuit and optical dynamic therapy probe being sequentially connected.
The breast tumor blood oxygen nanometer strengthens functional image Clinics and Practices system, is applied to the Clinics and Practices of breast tumor.
The operation principle of the present embodiment：
Targeted nano tumor staining agent local injection or the approach such as oral are entered internal targeting breast tissues, simultaneously, there is module under the control of device controller in infrared ray, produce the infrared drive signal of characteristic frequency and pulsewidth, drive infrared emitting probe to produce the infrared light of certain power and specific wavelength, and be irradiated to treatment target corresponding site；Then, the blood flow of infrared imaging module collection treatment target specific region, blood oxygen and the tumor tissues image being colored, then feed back to main control computer and are analyzed and process；Further according to the analyzing and diagnosing result of main control computer, the HONGGUANG or near infrared light that optical dynamic therapy module produces specific wavelength and power is controlled by device controller, the red wavelength range that the optical dynamic therapy module sends is 620-700nm or near-infrared wavelength scope is 700-800nm, sensitiser absorption in irradiated lesion position, tumor tissues or tumor cell can produce photodynamic reaction to after the light energy of the wavelength（Photochemical reaction）Generate the very strong singlet oxygen of activity and（Or）There is oxidation reaction in free radical, singlet oxygen and various biomacromolecules, and be brought rapidly up killing tumor cell to certain temperature, realize AT optical dynamic therapy.
Embodiment 2
The present embodiment difference from Example 1 is：The infrared CCD photographic head is provided with infrared fileter.So that acquired image is not disturbed by extraneous visible ray, background noise is reduced.
Embodiment 3
The present embodiment difference from Example 2 is：The diagnosis and therapy system also includes infrared temperature detecting module, and the infrared temperature detecting module is connected with device controller.The function of infrared temperature detecting module is that the temperature to target area carries out real-time monitoring, and feed back to device controller and main control computer, reference data is provided for optical dynamic therapy module output, is made to better control over the output of optical dynamic therapy module, is improved therapeutic effect.
Embodiment 4：
A kind of breast tumor blood oxygen nanometer strengthens functional image Clinics and Practices system, including main control computer, device controller, infrared imaging module, infrared ray occur module and optical dynamic therapy module；The main control computer is connected by universal serial bus with device controller；There is module with optical dynamic therapy module, infrared ray respectively and be connected in the device controller；The infrared imaging module is connected with main control computer by bus.
The infrared imaging module is provided with image pick-up card, the infrared CCD photographic head being sequentially connected.The infrared line drive circuit and infrared emitting probe being sequentially connected be provided with and module in the infrared ray there is.The optical dynamic therapy module is provided with the drive circuit and optical dynamic therapy probe being sequentially connected.
The operation principle of the present embodiment：
Targeted nano tumor staining agent local injection or the approach such as oral are entered internal targeting breast tissues, simultaneously, there is module under the control of device controller in infrared ray, produce the infrared drive signal of characteristic frequency and pulsewidth, drive infrared emitting probe to produce the infrared light of certain power and specific wavelength, and be irradiated to treatment target corresponding site；Then, the blood flow of infrared imaging module collection treatment target specific region, blood oxygen and the tumor tissues image being colored, then feed back to main control computer and are analyzed and process；Further according to the analyzing and diagnosing result of main control computer, the HONGGUANG or near infrared light that optical dynamic therapy module produces specific wavelength and power is controlled by device controller, the optical dynamic therapy module sends red wavelength range for the 620-670nm or a length of 740-760nm of near-infrared light waves, sensitiser absorption in irradiated lesion position, tumor tissues or tumor cell can produce photodynamic reaction to after the light energy of the wavelength（Photochemical reaction）Generate the very strong singlet oxygen of activity and（Or）There is oxidation reaction in free radical, singlet oxygen and various biomacromolecules, and be brought rapidly up killing tumor cell to certain temperature, realize AT optical dynamic therapy.
Claims (6)
1. a kind of breast tumor blood oxygen nanometer strengthens functional image Clinics and Practices system and its application, it is characterised in that：There is module and optical dynamic therapy module in main control computer, device controller, infrared imaging module, infrared ray；The main control computer is connected by universal serial bus with device controller；There is module with optical dynamic therapy module, infrared ray respectively and be connected in the device controller；The infrared imaging module is connected with main control computer by bus；The optical dynamic therapy module is provided with the drive circuit and optical dynamic therapy probe being sequentially connected.
2. breast tumor blood oxygen nanometer according to claim 1 strengthens functional image Clinics and Practices system and its application, it is characterised in that：The infrared imaging module is provided with image pick-up card, the infrared CCD photographic head being sequentially connected.
3. breast tumor blood oxygen nanometer according to claim 2 strengthens functional image Clinics and Practices system and its application, it is characterised in that：The infrared CCD photographic head is provided with infrared fileter.
4. breast tumor blood oxygen nanometer according to claim 1 strengthens functional image Clinics and Practices system and its application, it is characterised in that：The infrared line drive circuit and infrared emitting probe being sequentially connected be provided with and module in the infrared ray there is.
5. functional image Clinics and Practices system and its application are strengthened according to the arbitrary described breast tumor blood oxygen nanometer of claim 1-4, it is characterised in that：The diagnosis and therapy system also includes infrared temperature detecting module, and the infrared temperature detecting module is connected with device controller.
6. breast tumor blood oxygen nanometer according to claim 1 strengthens its application of functional image Clinics and Practices system, it is characterised in that：It is applied to the Clinics and Practices of breast tumor.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108185989A (en) * | 2017-12-28 | 2018-06-22 | 中国人民解放军陆军军医大学第附属医院 | Early stage mammary gland disease Multifunction diagnosing therapeutic equipment and control method |
| CN109171029A (en) * | 2018-08-12 | 2019-01-11 | 华东交通大学 | It is a kind of for detecting the underwear of tumor of breast |
| CN110367999A (en) * | 2019-07-17 | 2019-10-25 | 李宏杰 | A kind of imaging of mammary gland blood-oxygen functional is aided with thermotherapy early-stage breast cancer detection system |
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| CN1810210A (en) * | 2005-09-02 | 2006-08-02 | 深圳市国基科技有限公司 | Mammary gland blood oxygen function imaging method and system |
| CN102166182A (en) * | 2011-01-24 | 2011-08-31 | 上海交通大学 | Nanometer probe and application thereof in tumor diagnosis composition and photodynamic therapy |
| CN103768728A (en) * | 2014-01-10 | 2014-05-07 | 玉林师范学院 | Tumor photodynamic/photo-thermal therapy instrument based on 3D-LED array cold light source |
| CN205163039U (en) * | 2015-11-11 | 2016-04-20 | 南宁科伦新技术有限公司 | Diagnosis of tumor of breast blood oxygen nanometer enhance function image and treatment system |
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2015
- 2015-11-11 CN CN201510764927.7A patent/CN106667430A/en active Pending
Patent Citations (4)
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| CN1810210A (en) * | 2005-09-02 | 2006-08-02 | 深圳市国基科技有限公司 | Mammary gland blood oxygen function imaging method and system |
| CN102166182A (en) * | 2011-01-24 | 2011-08-31 | 上海交通大学 | Nanometer probe and application thereof in tumor diagnosis composition and photodynamic therapy |
| CN103768728A (en) * | 2014-01-10 | 2014-05-07 | 玉林师范学院 | Tumor photodynamic/photo-thermal therapy instrument based on 3D-LED array cold light source |
| CN205163039U (en) * | 2015-11-11 | 2016-04-20 | 南宁科伦新技术有限公司 | Diagnosis of tumor of breast blood oxygen nanometer enhance function image and treatment system |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108185989A (en) * | 2017-12-28 | 2018-06-22 | 中国人民解放军陆军军医大学第附属医院 | Early stage mammary gland disease Multifunction diagnosing therapeutic equipment and control method |
| CN109171029A (en) * | 2018-08-12 | 2019-01-11 | 华东交通大学 | It is a kind of for detecting the underwear of tumor of breast |
| CN110367999A (en) * | 2019-07-17 | 2019-10-25 | 李宏杰 | A kind of imaging of mammary gland blood-oxygen functional is aided with thermotherapy early-stage breast cancer detection system |
| CN110367999B (en) * | 2019-07-17 | 2021-07-09 | 李宏杰 | Breast blood oxygen function imaging assisted with thermal therapy early-stage breast cancer detection system |
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