CN105919557B - Multi-mode imaging system and the multi-modality imaging method for applying it - Google Patents
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- 238000010521 absorption reaction Methods 0.000 description 2
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- 238000001727 in vivo Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
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Abstract
The present invention provides a kind of multi-mode imaging system and using its multi-modality imaging method.The multi-mode imaging system includes: CT imaging device, even number PET imaging device, SPECT imaging device, opto-acoustic imaging devices, rotating device and control device, rotating device forms the accommodation space for placing biological sample to be imaged, rotating device can be rotated relative to biological sample to be imaged, CT imaging device, even number PET imaging device, SPECT imaging device and opto-acoustic imaging devices around accommodation space and are spaced apart and arranged on rotating device, and it is electrically connected respectively with control device, wherein, even number PET imaging device is symmetrical arranged relative to biological sample to be imaged.It applies the technical scheme of the present invention, which solves the problems, such as that multiple single mode imaging techniques can not be combined to form over time and space to the medical imaging techniques of mutual supplement with each other's advantages in the prior art.
Description
Technical field
The present invention relates to medical imaging technology fields, and in particular, to its more of a kind of multi-mode imaging system and application
Modality method.
Background technique
Modern medicine imaging technique belongs to a kind of detection method of non-intrusion type, by providing the knot of tissue, organ
To be used for medical diagnosis, medical imaging technology plays more and more important angle in human lives for structure and function image
Color.
Medical imaging technology is generally divided into structure imaging technology and functional imaging technology two major classes.Common structure imaging skill
Art includes CT imaging technique, MRI imaging technique and ultrasonic imaging technique, and functional imaging technology includes functional MRI imaging skill
Art, SPECT imaging technique, PET imaging technique and OCT image technology.
CT imaging technique is a kind of medical imaging technology based on X-ray, can scan target and specify region and generate disconnected
Tomographic image, and there is high-resolution.PET imaging technique is usually imaged using the radioactive nucleus being injected in vivo, Ke Yidong
Reflect to state the physiology and Biochemical Information of organism.SPECT imaging technique prepares nucleic medicine without expensive cyclotron
Object, but its spatial resolution sum number wants far short of what is expected it is believed that making an uproar and comparing PET imaging technique.Photoacoustic imaging technology refers to: when wide beam is short
When pulse laser irradiation biological tissue, it is located at the intracorporal absorber of tissue (such as tumour) and absorbs pulsed light energy, so that it is swollen to heat up
It is swollen, generate ultrasonic wave；At this moment, it can receive the ultrasonic wave of these unofficial biography positioned at the supersonic sounding device on organizer surface, and
The image that energy absorption is distributed in tissue is rebuild according to the photoacoustic signal detected.Photoacoustic imaging technology detection is ultrasound
Signal, reflection be energy absorption difference, the advantages of which combines optics and ultrasonic two kinds of imaging techniques well.
But it in the prior art still can not be by CT imaging technique, PET imaging technique, SPECT imaging technique and photoacoustic imaging
Technology combines to form the medical imaging techniques of mutual supplement with each other's advantages over time and space.
Summary of the invention
The purpose of the present invention is to provide a kind of multi-mode imaging system and using its multi-modality imaging method, it is intended to solve
Multiple single mode imaging techniques can not certainly be combined to form over time and space to the medical treatment of mutual supplement with each other's advantages in the prior art
The problem of imaging technique.
In order to solve the above technical problems, the technical scheme is that providing a kind of multi-mode imaging system, comprising: CT
Imaging device, even number PET imaging device, SPECT imaging device, opto-acoustic imaging devices, rotating device and control device, rotation
Device forms the accommodation space for placing biological sample to be imaged, and rotating device can be rotated relative to biological sample to be imaged,
CT imaging device, even number PET imaging device, SPECT imaging device and opto-acoustic imaging devices surround accommodation space and interval
Ground is arranged on the spinning device, CT imaging device, even number PET imaging device, SPECT imaging device and opto-acoustic imaging devices
It is electrically connected respectively with control device, wherein even number PET imaging device is symmetrical arranged relative to biological sample to be imaged.
Optionally, CT imaging device includes CT bulb and CT detector, and CT bulb and CT detector are installed in rotating dress
It sets, and CT bulb and CT detector are symmetrical arranged relative to biological sample to be imaged, wherein CT detector and control device electricity
Connection.
Optionally, opto-acoustic imaging devices include ultrasonic transducer and laser, and ultrasonic transducer is installed on the spinning device,
Laser is fixedly installed relative to biological sample to be imaged, wherein ultrasonic transducer is electrically connected with the controller.
Optionally, the line between biological sample and laser to be imaged be horizontal axis, rotating device relative to at
As biological sample rotates in the perpendicular perpendicular to horizontal axis.
Optionally, the line between biological sample and laser to be imaged be vertical axis, rotating device relative to at
As biological sample rotates in the horizontal plane perpendicular to vertical axis.
Optionally, multi-mode imaging system further includes biological sample bearing seat to be imaged, the biological sample carrying to be imaged
The direction of line of the seat between biological sample to be imaged and laser is movably disposed, and in carrying out imaging operation
In accommodation space.
Optionally, multi-mode imaging system further includes radiation-resistance mask, and rotating device is mounted in radiation-resistance mask,
Control device is located at outside radiation-resistance mask.
Another party according to the present invention is graceful, provides a kind of multi-modality imaging method, before which uses
The multi-mode imaging system stated carries out imaging operation, and multi-modality imaging method includes following operating procedure:
Step S10: the rotating device for placing biological sample to be imaged and being placed in multi-mode imaging system is formed by appearance
It receives in space；
Step S20: the CT imaging device, PET imaging device, SPECT imaging device, optoacoustic of multi-mode imaging system are opened
At least two in imaging device, be then turned on rotating device make CT imaging device, PET imaging device, SPECT imaging device and
Opto-acoustic imaging devices are rotated around biological sample to be imaged to acquire the data information of biological sample to be imaged；
Step S30: the control device of multi-mode imaging system is analyzed according to data information and rebuilds biology to be imaged
The three-dimensional multimode state image of sample.
Optionally, in the imaging operation of step S20, when PET imaging device and SPECT imaging device are opened simultaneously
When, preset energy threshold values is arranged simultaneously to PET imaging device and SPECT imaging device, PET imaging device is made to detect energy value
Greater than the gamma-rays of preset energy threshold values, SPECT imaging device is made to detect the gamma-rays that energy value is less than preset energy threshold values.
Optionally, in the imaging operation of step S20, when opening CT imaging device, rotating device relative to
Imaging biological samples close CT imaging device after turning over a circumference to terminate the acquisition operation of CT data information；Alternatively, first protecting
It is motionless to hold rotating device, and rotates biological sample to be imaged in accommodation space, then in the same of Imaging biological samples rotation
When make rotating device rotate an angle step, rotating device rotate an angle step during close CT imaging device
To terminate the acquisition operation of CT data information.
In the present invention, rotated by CT imaging device, PET imaging device, SPECT imaging device and opto-acoustic imaging devices
The respective imaging data information of Imaging biological samples progress is treated in same time, the same space position on device to be acquired,
Then the three-dimensional multimode state image of biological sample to be imaged is rebuild after being uniformly analyzed and processed in control device.Therefore,
The application of the multi-mode imaging system, being able to solve in the prior art can not be by multiple single mode imaging technique in time and space
On the problem of combining to form the medical imaging techniques of mutual supplement with each other's advantages.
Detailed description of the invention
Fig. 1 is the schematic view of the front view of the embodiment of multi-mode imaging system of the invention；
Fig. 2 is the right side structural representation of Fig. 1.
In the accompanying drawings:
11, CT bulb；12, CT detector；20, PET imaging device；
30, SPECT imaging device；41, ultrasonic transducer；42, laser；
50, rotating device；60, biological sample to be imaged.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to the accompanying drawings and embodiments, right
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.
It should be noted that it can be directly another when element is referred to as " being fixed on " or " being set to " another element
On one element or indirectly on another element.When an element referred to as " is connected to " another element, it can be with
It is directly to another element or is indirectly connected on another element.
It should also be noted that, the positional terms such as left and right, upper and lower in the present embodiment, be only each other relative concept or
It is reference with the normal operating condition of product, and should not be regarded as restrictive.
As depicted in figs. 1 and 2, the multi-mode imaging system of the present embodiment includes CT imaging device, even number PET imaging dress
Set 20, SPECT imaging device 30, opto-acoustic imaging devices, rotating device 50 and control device.The rotation of the multi-mode imaging system
Device 50 forms the accommodation space for placing biological sample 60 to be imaged, and rotating device 50 is relative to biological sample 60 to be imaged
It can be rotated, CT imaging device, even number PET imaging device 20, SPECT imaging device 30 and opto-acoustic imaging devices are around receiving
It space and is spaced apart and arranged on rotating device 50, CT imaging device, even number PET imaging device 20, SPECT imaging device 30
And opto-acoustic imaging devices are electrically connected with control device respectively, wherein even number PET imaging device 20 is relative to biology to be imaged
Sample 60 is symmetrical arranged.
By CT imaging device, PET imaging device 20, SPECT imaging device 30 and opto-acoustic imaging devices in rotating device
It treats Imaging biological samples 60 in same time, the same space position on 50 and carries out respective imaging data information and be acquired,
Then the three-dimensional multimode state image of biological sample 60 to be imaged is rebuild after being uniformly analyzed and processed in control device.Cause
This, the application of the multi-mode imaging system, be able to solve in the prior art can not by multiple single mode imaging techniques in the time and
The problem of spatially combining to form the medical imaging techniques of mutual supplement with each other's advantages will by the strong point of fusion different modalities imaging
The tissue morphology and function/molecular information of acquisition complement one another, available more fully information, facilitate disease early diagnosis
And the determination and dynamic evaluation of therapeutic scheme.
In the present embodiment, CT imaging device includes CT bulb 11 and CT detector 12, and CT bulb 11 is penetrated for generating X
Line is treated Imaging biological samples 60 by X-ray and is irradiated, and CT detector 12 passes through biological sample to be imaged for collecting
X-ray signal after 60.CT bulb 11 and CT detector 12 are respectively mounted on the spinning device, and CT bulb 11 and CT detector 12
It is symmetrical arranged relative to biological sample 60 to be imaged, to make X-ray can be after irradiating biological sample 60 to be imaged at once
It is received by CT detector 12 and carries out data information collection, without reaching CT detector 12 after being converted X-ray again
And lead to the decrease of X-ray energy.Wherein, CT detector 12 is electrically connected with control device, and CT detector 12 penetrates collected X
Line signal is sent to the analysis processing that control device carries out data information.
As shown in Fig. 2, the opto-acoustic imaging devices of the present embodiment include ultrasonic transducer 41 and laser 42.Laser 42 is used
Imaging biological samples 60 are treated issuing short-pulse laser to be irradiated, to generate corresponding ultrasound data information；Ultrasound
Energy converter is used to acquire short-pulse laser and biological sample 60 to be imaged acts on issued ultrasonic wave, so that ultrasonic wave be converted
Data information for energy information as photoacoustic imaging.Ultrasonic transducer 41 is mounted on rotating device 50, and laser 42 is opposite
It is fixedly installed in biological sample 60 to be imaged, wherein ultrasonic transducer 41 is electrically connected with the controller.
Specifically, the line between the biological sample to be imaged 60 and laser 42 of the present embodiment is horizontal axis, rotation
Device 50 rotates in the perpendicular perpendicular to horizontal axis relative to biological sample 60 to be imaged, i.e., rotating device 50 is perpendicular
It is rotated in a counter-clockwise direction in facing directly around biological sample 60 to be imaged.As shown in Fig. 2, being that origin establishes space with laser 42
Rectangular coordinate system xyz, coordinate system x-axis are trunnion axis, and coordinate system y-axis is vertical axes, and coordinate system z-axis is biological sample to be imaged
Line between product 60 and laser 42 is horizontal axis, and the perpendicular that rotating device 50 rotates is parallel to what x-axis y-axis determined
Plane, rotating device 50 are rotated around z-axis.
In the present embodiment, in order to it is more convenient, steadily place biological sample 60 to be imaged, therefore multi-modality imaging system
System further includes biological sample bearing seat to be imaged, and the biological sample bearing seat to be imaged is in biological sample 60 to be imaged and laser
The direction of line between 42 is movably disposed, before placing biological sample 60 to be imaged, biological sample carrying to be imaged
Seat is moved along the z-axis direction out of accommodation space, after placing completion biological sample 60 to be imaged, biological sample to be imaged
Bearing seat moves into accommodation space along the z-axis direction together with biological sample 60 to be imaged, and is carrying out imaging operation
In always situated in accommodation space.
Preferably due in the process for carrying out operation acquisition information to the multi-mode imaging system, some radioactive rays
Meeting generates damage to the personal safety of staff, and therefore, multi-mode imaging system further includes radiation-resistance mask, the radiation protection
Shielding case be it is horizontally disposed, rotating device 50 is mounted in radiation-resistance mask, and control device is located at outside radiation-resistance mask,
To protect staff not by the radiation damage of radioactive ray, it is ensured that the health of human body of staff.
In another feasible embodiment, compared with above-described embodiment, there is following difference.Biology to be imaged
Line between sample 60 and laser 42 is vertical axis, rotating device 50 relative to biological sample 60 to be imaged perpendicular to
Rotation in the horizontal plane of vertical axis.At this point, the z-axis of rectangular coordinate system in space xyz is vertical axes, x-axis y-axis determines one jointly
Horizontal plane, the plane that rotating device 50 rotates counterclockwise is parallel with the horizontal plane that x-axis y-axis determines, biological sample carrying to be imaged
Seat is is vertically arranged and z-axis direction is moved up and down along z-axis.In addition to above-mentioned difference, remaining structure is all the same, no longer superfluous herein
It states.
According to another aspect of the present invention, a kind of multi-modality imaging method is provided.Before the multi-modality imaging method uses
The multi-mode imaging system stated carries out imaging operation, and multi-modality imaging method includes following operating procedure:
Step S10: the rotating device 50 for placing biological sample 60 to be imaged and being placed in multi-mode imaging system is formed
Accommodation space in, when needing the object that is imaged is Disease, patient can be lain low or be stood in biological sample to be imaged
On bearing seat, then biological sample bearing seat to be imaged is moved together together with patient as in accommodation space；
Step S20: open the CT imaging device of multi-mode imaging system, PET imaging device 20, SPECT imaging device 30,
At least two (can open two, three, four therein) in opto-acoustic imaging devices, being then turned on rotating device 50 makes CT
Imaging device, PET imaging device 20, SPECT imaging device 30 and opto-acoustic imaging devices are rotated around biological sample 60 to be imaged
To acquire the data information of biological sample to be imaged, rotating device 50 rotate during, when rotating device 50 to complete it is more
The data information acquisition of a mode, then needing relatively to turn over n between rotating device 50 and biological sample to be imaged 60, (n is greater than 0
Integer) a circumference；
Step S30: the control device of multi-mode imaging system is analyzed according to data information and rebuilds biology to be imaged
The three-dimensional multimode state image of sample.
Wherein, in the imaging operation of the step S20 of this method, when PET imaging device 20 and SPECT imaging device 30
When opening simultaneously, preset energy threshold values is arranged simultaneously to PET imaging device 20 and SPECT imaging device 30, makes PET imaging device
20 detect the gamma-rays that energy value is greater than preset energy threshold values, and SPECT imaging device 30 is made to detect energy value less than default
The gamma-rays of energy threshold.
In addition, in the imaging operation of step S20, when opening CT imaging device, rotating device relative to at
CT imaging device is closed to terminate the acquisition operation of CT data information after turning over a circumference as biological sample, closes CT imaging dress
Set is to reduce CT dose of radiation.
Alternatively, when opening CT imaging device, first keeping rotating device 50 not in the imaging operation of step S20
It is dynamic, and rotate biological sample 60 to be imaged in accommodation space, then make to rotate while Imaging biological samples 60 rotate
Device 50, which rotates the angle step angle step, can be the random angle angle value between 1 °~180 °, at 50 turns of rotating device
CT imaging device is closed during a dynamic angle step to terminate the acquisition operation of CT data information.It is complete in rotating device 50
After an angle step, rotating device 50 is remain stationary a period of time (being greater than 1s), is adopted completing CT data information
CT imaging device can be closed, can also be closed ahead of time, to reduce CT dose of radiation after collection.Then rotating device 50 to
Imaging biological samples 60 continue to rotate angle step while rotation, and stop 1s or more the time later.
The above is merely preferred embodiments of the present invention, be not intended to limit the invention, it is all in spirit of the invention and
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within principle.
Claims (7)
1. a kind of multi-mode imaging system characterized by comprising CT imaging device, even number PET imaging device, SPECT at
As device, opto-acoustic imaging devices, rotating device and control device, the rotating device is formed for placing biological sample to be imaged
Accommodation space, the rotating device relative to the biological sample to be imaged can be rotated, the CT imaging device, even number institute
PET imaging device and the SPECT imaging device are stated around the accommodation space and is spaced apart and arranged in the rotating device
On, PET imaging device described in the CT imaging device, even number, the SPECT imaging device and the opto-acoustic imaging devices
It is electrically connected with the control device respectively, wherein PET imaging device described in even number is relative to the biological sample pair to be imaged
Claim setting, the opto-acoustic imaging devices include ultrasonic transducer and laser, and the ultrasonic transducer is mounted on the rotating dress
It sets, the laser is fixedly installed relative to the biological sample to be imaged, the biological sample to be imaged and the laser
Line between device is horizontal axis, and the rotating device is relative to the biological sample to be imaged perpendicular to the trunnion axis
Rotation or the line between the biological sample to be imaged and the laser are vertical axis, institute in the perpendicular of line
It states rotating device and is rotated in the horizontal plane perpendicular to the vertical axis relative to the biological sample to be imaged.
2. multi-mode imaging system as described in claim 1, which is characterized in that the CT imaging device includes CT bulb and CT
Detector, the CT bulb and the CT detector are installed on the rotating device, and the CT bulb and the CT are visited
It surveys device to be symmetrical arranged relative to the biological sample to be imaged, wherein the CT detector is electrically connected with the control device.
3. multi-mode imaging system as described in claim 1, which is characterized in that the multi-mode imaging system further include at
As biological sample bearing seat, the biological sample bearing seat to be imaged is between the biological sample to be imaged and the laser
The direction of line is movably disposed, and is located in the accommodation space in carrying out imaging operation.
4. multi-mode imaging system as claimed in claim 3, which is characterized in that the multi-mode imaging system further includes anti-spoke
Shielding case is penetrated, the rotating device is mounted in the radiation-resistance mask, and the control device is located at the radiation-resistant glass
Cover is outer.
5. a kind of multi-modality imaging method, which is characterized in that the multi-modality imaging method uses any one of claims 1 to 4
The multi-mode imaging system carries out imaging operation, and the multi-modality imaging method includes following operating procedure:
Step S10: the rotating device for placing biological sample to be imaged and being placed in the multi-mode imaging system is formed by appearance
It receives in space；
Step S20: the CT imaging device, PET imaging device, SPECT imaging device, optoacoustic of the multi-mode imaging system are opened
At least two in imaging device, being then turned on the rotating device makes the CT imaging device, the PET imaging device, institute
SPECT imaging device and the ultrasonic transducer are stated around the biological sample rotation to be imaged to acquire the biology to be imaged
The data information of sample；
Step S30: the control device of the multi-mode imaging system analyzed according to the data information and rebuild it is described to
The three-dimensional multimode state image of Imaging biological samples.
6. multi-modality imaging method as claimed in claim 5, which is characterized in that in the imaging operation of the step S20
In, when the PET imaging device and the SPECT imaging device are opened simultaneously, to the PET imaging device and described
Preset energy threshold values is arranged simultaneously in SPECT imaging device, and the PET imaging device is made to detect energy value greater than the default energy
The gamma-rays for measuring threshold values makes the SPECT imaging device detect the gamma-rays that energy value is less than the preset energy threshold values.
7. multi-modality imaging method as claimed in claim 5, which is characterized in that in the imaging operation of the step S20
In, when opening the CT imaging device,
The rotating device closes the CT imaging device after turning over a circumference relative to the biological sample to be imaged to tie
The acquisition of beam CT data information operates；
Alternatively, first keeping the rotating device motionless, and rotate the biological sample to be imaged in the accommodation space, so
So that the rotating device is rotated an angle step while Imaging biological samples rotate afterwards, turns in the rotating device
The CT imaging device is closed during a dynamic angle step to terminate the acquisition of CT data information operation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610348138.XA CN105919557B (en) | 2016-05-24 | 2016-05-24 | Multi-mode imaging system and the multi-modality imaging method for applying it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610348138.XA CN105919557B (en) | 2016-05-24 | 2016-05-24 | Multi-mode imaging system and the multi-modality imaging method for applying it |
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| Publication Number | Publication Date |
|---|---|
| CN105919557A CN105919557A (en) | 2016-09-07 |
| CN105919557B true CN105919557B (en) | 2019-09-17 |
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