CN106591126A - Small-size cell culture tank group apparatus - Google Patents
Small-size cell culture tank group apparatus Download PDFInfo
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- CN106591126A CN106591126A CN201710064139.6A CN201710064139A CN106591126A CN 106591126 A CN106591126 A CN 106591126A CN 201710064139 A CN201710064139 A CN 201710064139A CN 106591126 A CN106591126 A CN 106591126A
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- 238000004113 cell culture Methods 0.000 title claims abstract description 14
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000001301 oxygen Substances 0.000 claims abstract description 28
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 28
- 239000000463 material Substances 0.000 claims abstract description 18
- 230000002572 peristaltic effect Effects 0.000 claims abstract description 16
- 238000003756 stirring Methods 0.000 claims abstract description 11
- 239000003513 alkali Substances 0.000 claims abstract description 10
- 239000002253 acid Substances 0.000 claims abstract description 9
- 238000005057 refrigeration Methods 0.000 claims abstract description 8
- 239000004065 semiconductor Substances 0.000 claims abstract description 8
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 7
- 238000001816 cooling Methods 0.000 claims abstract description 4
- 238000010438 heat treatment Methods 0.000 claims abstract description 4
- 229910000838 Al alloy Inorganic materials 0.000 claims abstract description 3
- 239000006260 foam Substances 0.000 claims description 10
- 239000013530 defoamer Substances 0.000 claims description 9
- 239000006052 feed supplement Substances 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 3
- 239000002196 Pyroceram Substances 0.000 claims description 2
- 229910000831 Steel Inorganic materials 0.000 claims description 2
- 239000000956 alloy Substances 0.000 claims description 2
- 238000009833 condensation Methods 0.000 claims description 2
- 230000005494 condensation Effects 0.000 claims description 2
- 238000003913 materials processing Methods 0.000 claims description 2
- 239000010959 steel Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 1
- 239000007789 gas Substances 0.000 abstract description 2
- 239000002518 antifoaming agent Substances 0.000 abstract 1
- 238000005485 electric heating Methods 0.000 abstract 1
- 238000009434 installation Methods 0.000 abstract 1
- 239000010935 stainless steel Substances 0.000 abstract 1
- 229910001220 stainless steel Inorganic materials 0.000 abstract 1
- 230000001502 supplementing effect Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 description 5
- 230000004151 fermentation Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000012531 culture fluid Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000013139 quantization Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000012549 training Methods 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/58—Reaction vessels connected in series or in parallel
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/20—Degassing; Venting; Bubble traps
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/26—Conditioning fluids entering or exiting the reaction vessel
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/02—Means for regulation, monitoring, measurement or control, e.g. flow regulation of foam
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
- C12M41/22—Heat exchange systems, e.g. heat jackets or outer envelopes in contact with the bioreactor walls
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/42—Means for regulation, monitoring, measurement or control, e.g. flow regulation of agitation speed
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
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- Genetics & Genomics (AREA)
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- Biotechnology (AREA)
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- General Engineering & Computer Science (AREA)
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- Analytical Chemistry (AREA)
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The present invention relates to a small-size cell culture tank group apparatus, which comprises four cell culture tanks having a volume of 1 L and sequentially connected in series through 5 pipelines, wherein the lower half portions of the four cell culture tanks are respectively provided with an aluminum alloy bush, the bottom portions of the bushes are respectively provided with a semiconductor refrigeration chip for cooling the tank, the side surfaces of the bushes are respectively wrapped with an electric heating plate for heating the tank, the top portions of each culture tank are respectively provided with a stainless steel cover plate, the periphery of the cover plate is provided with four sensor installation holes, a material feeding inlet, an oxygen inlet and a tail gas outlet, the centers of the cover plates are respectively provided with a stirring motor and drive the stirring paddles in the tanks through stirring shafts, the material feeding inlets on the cover plates are connected to the outlets of four peristaltic pumps through soft pipes, the inlets of the four peristaltic pumps are respectively connected to the defoaming agent inlet, the material supplementing agent inlet, the alkali material inlet and the acid material inlet of the pipeline, and the oxygen inlets on the cover plates are connected to electromagnetic valves and rotor flow meters through soft pipes, and then are connected to the oxygen inlet of the pipeline. With the small-size cell culture tank group apparatus of the present invention, the biological cell culture process can be efficiently performed.
Description
Technical field
The present invention relates to new be related to biological culture equipment, and in particular to a kind of minicell culture tank group device, belong to
Production process apparatus field.
Background technology
Bioreactor is equipment indispensable in biology laboratory.With the progress that present Technology is at full speed, it is
Meet the requirement of laboratory multiple spot contrast experiment, many quantizations of culture tank and miniaturization more become the trend of current development.
In recent years, China's biological medicine industry obtained development at full speed, and biological fermentation field product variety also increases sharply.But while band
Series of problems, including the unreasonable products structure that blind expansion brings are come, product quality is not high, production cost is improved constantly
A series of problems, such as with foreign technology is depended on unduly.
At present biology laboratory generally carrys out to be carried out with fermentation method cell culture, and Bian small incubation tanks are (as using single
5L fermentation tanks are used as experimental facilitiess) to be tested, biology laboratory is in the urgent need to a kind of smallerization, parallelization, automatization's journey
The high small-sized biological bioreactor group device of degree.Bioreactor group device is by multiple laboratory scale minicell cultures
Tank and its regulator control system are constituted, and the cell culture condition of early stage are groped, process optimization provides good platform, are greatly reduced into
Originally with the research and development time.
The content of the invention
For the problems referred to above, in order to improve the level of biological cell culture equipment, patent of the present invention provides a kind of small-sized thin
Born of the same parents' culture tank group device.
The technical solution adopted in the present invention is：Including the cell training of four 1L volumes for passing sequentially through 5 road pipeline concatenations
Foster tank, 5 road pipelines are provided with oxygen intake, defoamer entrance, feed supplement agent entrance, alkali material entrance and acid material entrance；Four cells
The tank body of culture tank be with pyroceram materials processing into upper opening hollow cylinder, its outside lower half is equipped with
The sleeve of aluminum alloy material, sleeve bottom is enclosed with for tank equipped with the semiconductor refrigeration chip for tank cooling, cartridges sides
The electric boiling plate of heating；Each cell culture tank top is equipped with rustless steel cover plate, and cover plate surrounding has 4 sensor mounting hole, adds
Expect entrance, enter oxygen intake and offgas outlet；Cover plate central authorities are equipped with stirring motor, and by shaft stirring paddle in tank is driven；4
Sensor mounting hole is respectively mounted temperature sensor, pH sensors, dissolved oxygen sensor, foam sensor, and sensor is connected to control
Device processed；Charging entrance on cover plate is connected to the outlet of 4 peristaltic pumps in top by flexible pipe, and the entrance of 4 peristaltic pumps passes through
Flexible pipe is respectively coupled to the defoamer entrance of pipeline, feed supplement agent entrance, alkali material entrance and acid material entrance；The oxygen that enters on cover plate enters
Mouth couples electromagnetic valve by flexible pipe and spinner flowmeter is followed by the oxygen intake of pipeline；Offgas outlet on cover plate passes through flexible pipe
It is connected to the semiconductor refrigeration chip for condensation.
Control device includes PLC, touch screen, sensor, peristaltic pump and the electromagnetic valve of electrical connection, sensor peace
Fermentation tank top is mounted in, electromagnetic valve is arranged on oxygen pipeline, and 4 peristaltic pumps are separately mounted to defoamer, feed supplement agent, alkali
On material and sour expects pipe road.
The Advantageous Effects of patent of the present invention are：There is provided a kind of miniaturization, the small-sized biological cell culture of parallelization
Tank group device, control device is automatically controlled to the overall process of cell culture, and control cell cultivation process is entered with basis
OK.Control device gathers and monitors speed of agitator, oxygen flow, pot temperature, pH, dissolved oxygen, the foam of four bioreactors.
Description of the drawings
Fig. 1 is the structural representation of minicell culture tank group device.
Fig. 2 is the assembling schematic diagram of minicell culture tank group device.
Numbering 1,7,13,19 is temperature sensor in accompanying drawing 2, and 2,8,14,20 is pH sensors, and 3,9,15,21 is dissolved oxygen
Sensor, 4,10,16,22 is foam electrode, and 5,11,17,23 is sleeve electric boiling plate, and 6,12,18,24 is stirring motor, 54,
55th, 56,57 is shaft, and 58,59,60,61 is stirring paddle, and 25,27,29,31 is tail gas condensing semiconductor refrigeration chip,
26th, 28,30,32 is the cooling semiconductor refrigeration chip of tank, and 33,34,35,36 is culture tank, and 37,38,39,40 is top
Oxygen intake, 41,42,43,44 is top offgas outlet, and 50,51,52,53 is top-feed entrance, and 45 is that oxygen channel enters
Mouthful, 46 is defoamer entrance, and 47 is feed supplement agent entrance, and 48 is alkali pipe material entrance, and 49 is sour pipe material entrance,
P1-1, P2-1, P3-1, P4-1 are acid adding peristaltic pumps, and P1-2, P2-2, P3-2, P4-2 are to add alkali peristaltic pump, P1-3, P2-3, P3-
3rd, P4-3 is feed supplement peristaltic pump, and P1-4, P2-4, P3-4, P4-4 are defoamer peristaltic pumps, and V1, V2, V3, V4 are oxygen electromagnetic valves,
V5 is oxygen pipeline main valve, and R1, R2, R3, R4 are spinner flowmeters.
Specific embodiment
Below in conjunction with the accompanying drawings the specific embodiment of 2 pairs of patents of the present invention is described further：
Embodiment 1：
As shown in Fig. 2 connecting culture tank 33,34,35,36 by 5 road pipelines.Need oxygen electromagnetic valve before experiment
V1, V2, V3, V4 are closed, and the folder of offgas outlet 41,42,43,44 is dead, and to culture tank 33,34,35,36 vapor sterilization process is carried out.
Operation principle：(mode of operation of culture tank 33,34,35,36 is consistent, hereby only by taking the mode of operation of culture tank 33 as an example,
Description whole operation process.)
1) temperature in culture tank 33 is measured by temperature sensor 1, when measured temperature is less than setting value, starts set
Cylinder electrical heating 5 is heated up；When measured temperature is higher than setting value, starts semiconductor refrigeration chip 26 and lowered the temperature；
2) pH in culture tank 33 is measured by pH sensors 2, when pH measured values are higher than acid adding setting value, starts acid adding
Peristaltic pump P1-1, to culture fluid acid material is added；When pH measured values are less than alkali setting value is added, start plus alkali peristaltic pump P1-
2, add alkaline material to culture fluid；
3) stirring is coupled control with dissolved oxygen, and when dissolved oxygen is less than setting value, the rotating speed of stirring motor 6 increases；When dissolved oxygen is higher than to set
Definite value, the rotating speed of stirring motor 6 is reduced.
4) foam in culture tank 33 is measured by foam electrode 4, when foam increases the foam output report of foam electrode 4 is touched
Alert signal, subsequent start-up defoamer peristaltic pump P1-4 adds defoamer to fermentation liquid；When foam alarm signal disappears, closing disappears
Infusion peristaltic pump P1-4 stops froth breaking.
5) Oxygen control, by oxygen electromagnetic valve V1 oxygen turn-on and turn-off are controlled.
It is more than presently preferred embodiments of the present invention, any pro forma restriction, every foundation is not made to the present invention
The technical spirit of the present invention belongs to invention skill to any simple modification made for any of the above embodiments, equivalent variations and modification
In the range of art scheme.
Claims (1)
1. a kind of minicell culture tank group device, it is characterised in that including four 1L volumes for passing sequentially through 5 road pipelines concatenations
Bioreactor, 5 road pipelines be provided with oxygen intake, defoamer entrance, feed supplement agent entrance, alkali material entrance and acid material entrance；
The tank body of four bioreactors be with pyroceram materials processing into upper opening hollow cylinder, under it is outside
Sleeve of the half portion equipped with aluminum alloy material, sleeve bottom is equipped with the semiconductor refrigeration chip for tank cooling, cartridges sides parcel
There is the electric boiling plate for tank heating；Each cell culture tank top is equipped with rustless steel cover plate, and cover plate surrounding has 4 sensor peaces
Fill hole, the entrance that feeds, enter oxygen intake and offgas outlet；Cover plate central authorities are equipped with stirring motor, are driven in tank by shaft and are stirred
Mix oar；4 sensor mounting hole are respectively mounted temperature sensor, pH sensors, dissolved oxygen sensor, foam sensor, sensor
It is connected to control device；Charging entrance on cover plate is connected to the outlet of 4 peristaltic pumps in top by flexible pipe, 4 peristaltic pumps
Entrance is respectively coupled to the defoamer entrance of pipeline, feed supplement agent entrance, alkali material entrance and acid material entrance by flexible pipe；On cover plate
Enter the oxygen intake that oxygen intake is followed by pipeline by flexible pipe connection electromagnetic valve and spinner flowmeter；Offgas outlet on cover plate
Semiconductor refrigeration chip for condensation is connected to by flexible pipe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710064139.6A CN106591126B (en) | 2017-02-04 | 2017-02-04 | Small-size cell culture tank group device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710064139.6A CN106591126B (en) | 2017-02-04 | 2017-02-04 | Small-size cell culture tank group device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106591126A true CN106591126A (en) | 2017-04-26 |
| CN106591126B CN106591126B (en) | 2023-10-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710064139.6A Active CN106591126B (en) | 2017-02-04 | 2017-02-04 | Small-size cell culture tank group device |
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| Country | Link |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109401950A (en) * | 2018-11-09 | 2019-03-01 | 上海主元生物科技有限公司 | Magnetic stirring apparatus and heating refrigeration system for micromation installation for fermenting |
| CN109401951A (en) * | 2018-11-09 | 2019-03-01 | 上海主元生物科技有限公司 | A kind of micromation high throughput installation for fermenting |
| CN109443904A (en) * | 2019-01-02 | 2019-03-08 | 扬州工业职业技术学院 | A kind of materials chemistry prepares sampling analysis device |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204569936U (en) * | 2015-04-24 | 2015-08-19 | 江南大学 | A kind of small-sized fermentation tank group system |
-
2017
- 2017-02-04 CN CN201710064139.6A patent/CN106591126B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204569936U (en) * | 2015-04-24 | 2015-08-19 | 江南大学 | A kind of small-sized fermentation tank group system |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109401950A (en) * | 2018-11-09 | 2019-03-01 | 上海主元生物科技有限公司 | Magnetic stirring apparatus and heating refrigeration system for micromation installation for fermenting |
| CN109401951A (en) * | 2018-11-09 | 2019-03-01 | 上海主元生物科技有限公司 | A kind of micromation high throughput installation for fermenting |
| CN109443904A (en) * | 2019-01-02 | 2019-03-08 | 扬州工业职业技术学院 | A kind of materials chemistry prepares sampling analysis device |
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| Publication number | Publication date |
|---|---|
| CN106591126B (en) | 2023-10-13 |
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Effective date of registration: 20240531 Address after: 230000 B-1015, wo Yuan Garden, 81 Ganquan Road, Shushan District, Hefei, Anhui. Patentee after: HEFEI MINGLONG ELECTRONIC TECHNOLOGY Co.,Ltd. Country or region after: China Address before: No. 1800 road 214122 Jiangsu Lihu Binhu District City of Wuxi Province Patentee before: Jiangnan University Country or region before: China |
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