CN106574628A - 离心式血泵叶轮及流路径 - Google Patents
离心式血泵叶轮及流路径 Download PDFInfo
- Publication number
- CN106574628A CN106574628A CN201580044472.XA CN201580044472A CN106574628A CN 106574628 A CN106574628 A CN 106574628A CN 201580044472 A CN201580044472 A CN 201580044472A CN 106574628 A CN106574628 A CN 106574628A
- Authority
- CN
- China
- Prior art keywords
- annular
- magnet rotor
- gap
- flow path
- rotor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004369 blood Anatomy 0.000 title claims description 31
- 239000008280 blood Substances 0.000 title claims description 31
- 230000002093 peripheral effect Effects 0.000 claims abstract description 4
- 239000000725 suspension Substances 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 9
- 230000005779 cell damage Effects 0.000 claims description 5
- 208000037887 cell injury Diseases 0.000 claims description 5
- 239000000411 inducer Substances 0.000 claims description 5
- 239000012530 fluid Substances 0.000 claims 1
- 206010018910 Haemolysis Diseases 0.000 description 6
- 208000007536 Thrombosis Diseases 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 238000009434 installation Methods 0.000 description 5
- 230000006698 induction Effects 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 206010019280 Heart failures Diseases 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000008588 hemolysis Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000000649 photocoagulation Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04D—NON-POSITIVE-DISPLACEMENT PUMPS
- F04D29/00—Details, component parts, or accessories
- F04D29/04—Shafts or bearings, or assemblies thereof
- F04D29/046—Bearings
- F04D29/048—Bearings magnetic; electromagnetic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/20—Type thereof
- A61M60/205—Non-positive displacement blood pumps
- A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
- A61M60/226—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having mainly radial components
- A61M60/232—Centrifugal pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
- A61M60/804—Impellers
- A61M60/806—Vanes or blades
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
- A61M60/81—Pump housings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
- A61M60/818—Bearings
- A61M60/82—Magnetic bearings
- A61M60/822—Magnetic bearings specially adapted for being actively controlled
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04D—NON-POSITIVE-DISPLACEMENT PUMPS
- F04D13/00—Pumping installations or systems
- F04D13/02—Units comprising pumps and their driving means
- F04D13/06—Units comprising pumps and their driving means the pump being electrically driven
- F04D13/0666—Units comprising pumps and their driving means the pump being electrically driven the motor being of the plane gap type
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04D—NON-POSITIVE-DISPLACEMENT PUMPS
- F04D29/00—Details, component parts, or accessories
- F04D29/18—Rotors
- F04D29/22—Rotors specially for centrifugal pumps
- F04D29/2205—Conventional flow pattern
- F04D29/2216—Shape, geometry
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04D—NON-POSITIVE-DISPLACEMENT PUMPS
- F04D7/00—Pumps adapted for handling specific fluids, e.g. by selection of specific materials for pumps or pump parts
- F04D7/02—Pumps adapted for handling specific fluids, e.g. by selection of specific materials for pumps or pump parts of centrifugal type
- F04D7/04—Pumps adapted for handling specific fluids, e.g. by selection of specific materials for pumps or pump parts of centrifugal type the fluids being viscous or non-homogenous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
- A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
- A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/40—Details relating to driving
- A61M60/403—Details relating to driving for non-positive displacement blood pumps
- A61M60/422—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being electromagnetic, e.g. using canned motor pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
- A61M60/818—Bearings
- A61M60/824—Hydrodynamic or fluid film bearings
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Mechanical Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Electromagnetism (AREA)
- Geometry (AREA)
- External Artificial Organs (AREA)
- Structures Of Non-Positive Displacement Pumps (AREA)
Abstract
Description
Claims (22)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462013204P | 2014-06-17 | 2014-06-17 | |
US62/013,204 | 2014-06-17 | ||
US14/449,616 | 2014-08-01 | ||
US14/449,616 US10030664B2 (en) | 2014-06-17 | 2014-08-01 | Centrifugal blood pump impeller and flow path |
PCT/US2015/030754 WO2015195233A1 (en) | 2014-06-17 | 2015-05-14 | Centrifugal blood pump impeller and flow path |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106574628A true CN106574628A (zh) | 2017-04-19 |
CN106574628B CN106574628B (zh) | 2019-12-10 |
Family
ID=54835782
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201580044472.XA Active CN106574628B (zh) | 2014-06-17 | 2015-05-14 | 离心式血泵叶轮及流路径 |
Country Status (5)
Country | Link |
---|---|
US (2) | US10030664B2 (zh) |
EP (2) | EP3158203B1 (zh) |
JP (3) | JP2017518159A (zh) |
CN (1) | CN106574628B (zh) |
WO (1) | WO2015195233A1 (zh) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107296988A (zh) * | 2017-06-19 | 2017-10-27 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | 无叶片血泵 |
CN107469168A (zh) * | 2017-09-30 | 2017-12-15 | 北京安生生物技术有限责任公司 | 一种减少血栓发生的单自由度磁悬浮离心式叶轮 |
CN107519549A (zh) * | 2017-09-30 | 2017-12-29 | 清华大学天津高端装备研究院 | 一种新型单自由度磁悬浮离心式叶轮 |
CN107693869A (zh) * | 2017-09-30 | 2018-02-16 | 北京安生生物技术有限责任公司 | 一种能减少溶血和血栓的五自由度磁悬浮离心式叶轮 |
CN108175884A (zh) * | 2018-01-11 | 2018-06-19 | 深圳核心医疗器械有限公司 | 心室辅助泵 |
CN108785770A (zh) * | 2018-04-18 | 2018-11-13 | 清华大学天津高端装备研究院 | 一种能够减少溶血的体外血泵 |
CN110714926A (zh) * | 2018-07-11 | 2020-01-21 | 同心医疗器械(美国)有限公司 | 具有磁悬浮叶轮的紧凑型离心泵 |
CN111491677A (zh) * | 2017-12-05 | 2020-08-04 | 心脏器械股份有限公司 | 具有叶轮洗涤操作的血泵 |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USD792911S1 (en) * | 2014-10-10 | 2017-07-25 | Earthway Products, Inc. | Impeller |
KR101905781B1 (ko) * | 2017-03-06 | 2018-10-08 | 서강대학교산학협력단 | 원심형 혈액 펌프 |
US10632239B2 (en) * | 2017-12-08 | 2020-04-28 | Jervik Heart, Inc. | Single inflow double suction centrifugal blood pump |
KR102153561B1 (ko) * | 2018-07-17 | 2020-09-08 | 서강대학교산학협력단 | 원심형 혈액 펌프 |
EP3899283A1 (en) * | 2018-12-19 | 2021-10-27 | Pentair Flow Technologies, LLC | Pump comprising an impeller body provided as an oblique cone |
CN111298222B (zh) * | 2018-12-26 | 2022-09-23 | 东莞科威医疗器械有限公司 | 一种医用离心泵 |
CN109876218A (zh) * | 2019-03-28 | 2019-06-14 | 哈尔滨理工大学 | 一种植入式心室辅助装置 |
CN110559496A (zh) * | 2019-09-25 | 2019-12-13 | 中国医学科学院阜外医院 | 一种具有中心磁极结构的体外磁悬浮离心血泵 |
WO2021094140A1 (en) | 2019-11-12 | 2021-05-20 | Fresenius Medical Care Deutschland Gmbh | Blood treatment systems |
EP4058088A1 (en) | 2019-11-12 | 2022-09-21 | Fresenius Medical Care Deutschland GmbH | Blood treatment systems |
EP4058094A1 (en) | 2019-11-12 | 2022-09-21 | Fresenius Medical Care Deutschland GmbH | Blood treatment systems |
CN114746129A (zh) | 2019-11-12 | 2022-07-12 | 费森尤斯医疗护理德国有限责任公司 | 血液治疗*** |
CN111337659B (zh) * | 2020-03-16 | 2021-06-18 | 中南大学 | 血液剪切损伤模拟装置 |
EP4225422A1 (en) | 2020-10-12 | 2023-08-16 | KOC Universitesi | Implantable centrifugal cardiac assist pump having permanent magnets embedded in impeller |
CN115887908A (zh) * | 2022-10-20 | 2023-04-04 | 北京航空航天大学 | 一种人工心脏、血泵 |
CN117627955B (zh) * | 2023-12-05 | 2024-06-11 | 吉林大学 | 一种防破乳的胶乳泵叶轮 |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3867655A (en) * | 1973-11-21 | 1975-02-18 | Entropy Ltd | Shaftless energy conversion device |
US4666373A (en) * | 1986-03-20 | 1987-05-19 | Eiichi Sugiura | Impeller for rotary fluid machine |
US20040047753A1 (en) * | 2000-03-27 | 2004-03-11 | David Horvath | Ventricular assist system secondary impeller |
US20080124231A1 (en) * | 2006-11-28 | 2008-05-29 | Terumo Kabushiki Kaisha | Sensorless Magnetic Bearing Type Blood Pump Apparatus |
CN101371041A (zh) * | 2006-01-13 | 2009-02-18 | 哈特威尔公司 | 旋转式血泵 |
CN102341600A (zh) * | 2009-03-06 | 2012-02-01 | Ntn株式会社 | 离心式泵装置 |
CN103216453A (zh) * | 2013-04-07 | 2013-07-24 | 清华大学 | 一种动压悬浮式双流动泵 |
JP2013213413A (ja) * | 2012-03-30 | 2013-10-17 | National Institute Of Advanced Industrial Science & Technology | 遠心血液ポンプ |
CN103591028A (zh) * | 2013-10-23 | 2014-02-19 | 北京航天控制仪器研究所 | 一种用于治疗心脏功能衰竭的心尖植入式离心泵 |
Family Cites Families (4)
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AU7360798A (en) * | 1997-09-24 | 1999-04-12 | Cleveland Clinic Foundation, The | Flow controlled blood pump system |
JP2003269378A (ja) * | 2002-03-14 | 2003-09-25 | San Medical Gijutsu Kenkyusho:Kk | 遠心ポンプ |
WO2005028872A2 (en) * | 2003-09-18 | 2005-03-31 | Myrakelle, Llc | Rotary blood pump |
EP2822614B1 (en) | 2012-03-05 | 2016-12-28 | Thoratec Corporation | Modular implantable medical pump |
-
2014
- 2014-08-01 US US14/449,616 patent/US10030664B2/en active Active
-
2015
- 2015-05-14 CN CN201580044472.XA patent/CN106574628B/zh active Active
- 2015-05-14 WO PCT/US2015/030754 patent/WO2015195233A1/en active Application Filing
- 2015-05-14 EP EP15810253.3A patent/EP3158203B1/en active Active
- 2015-05-14 EP EP19212970.8A patent/EP3636935B1/en active Active
- 2015-05-14 JP JP2017519207A patent/JP2017518159A/ja active Pending
-
2017
- 2017-10-25 US US15/793,421 patent/US10473105B2/en active Active - Reinstated
-
2018
- 2018-12-28 JP JP2018246360A patent/JP2019069225A/ja active Pending
-
2021
- 2021-02-24 JP JP2021027491A patent/JP7248723B2/ja active Active
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3867655A (en) * | 1973-11-21 | 1975-02-18 | Entropy Ltd | Shaftless energy conversion device |
US4666373A (en) * | 1986-03-20 | 1987-05-19 | Eiichi Sugiura | Impeller for rotary fluid machine |
US20040047753A1 (en) * | 2000-03-27 | 2004-03-11 | David Horvath | Ventricular assist system secondary impeller |
CN101371041A (zh) * | 2006-01-13 | 2009-02-18 | 哈特威尔公司 | 旋转式血泵 |
US20080124231A1 (en) * | 2006-11-28 | 2008-05-29 | Terumo Kabushiki Kaisha | Sensorless Magnetic Bearing Type Blood Pump Apparatus |
CN102341600A (zh) * | 2009-03-06 | 2012-02-01 | Ntn株式会社 | 离心式泵装置 |
JP2013213413A (ja) * | 2012-03-30 | 2013-10-17 | National Institute Of Advanced Industrial Science & Technology | 遠心血液ポンプ |
CN103216453A (zh) * | 2013-04-07 | 2013-07-24 | 清华大学 | 一种动压悬浮式双流动泵 |
CN103591028A (zh) * | 2013-10-23 | 2014-02-19 | 北京航天控制仪器研究所 | 一种用于治疗心脏功能衰竭的心尖植入式离心泵 |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107296988A (zh) * | 2017-06-19 | 2017-10-27 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | 无叶片血泵 |
CN107469168B (zh) * | 2017-09-30 | 2024-04-02 | 北京安生生物技术有限责任公司 | 一种减少血栓发生的单自由度磁悬浮离心式叶轮 |
CN107469168A (zh) * | 2017-09-30 | 2017-12-15 | 北京安生生物技术有限责任公司 | 一种减少血栓发生的单自由度磁悬浮离心式叶轮 |
CN107519549A (zh) * | 2017-09-30 | 2017-12-29 | 清华大学天津高端装备研究院 | 一种新型单自由度磁悬浮离心式叶轮 |
CN107693869A (zh) * | 2017-09-30 | 2018-02-16 | 北京安生生物技术有限责任公司 | 一种能减少溶血和血栓的五自由度磁悬浮离心式叶轮 |
CN107693869B (zh) * | 2017-09-30 | 2024-04-02 | 北京安生生物技术有限责任公司 | 一种能减少溶血和血栓的五自由度磁悬浮离心式叶轮 |
CN111491677A (zh) * | 2017-12-05 | 2020-08-04 | 心脏器械股份有限公司 | 具有叶轮洗涤操作的血泵 |
US11969588B2 (en) | 2017-12-05 | 2024-04-30 | Heartware, Inc. | Blood pump with impeller rinse operation |
CN111491677B (zh) * | 2017-12-05 | 2023-12-01 | 心脏器械股份有限公司 | 具有叶轮洗涤操作的血泵 |
CN108175884A (zh) * | 2018-01-11 | 2018-06-19 | 深圳核心医疗器械有限公司 | 心室辅助泵 |
CN108785770A (zh) * | 2018-04-18 | 2018-11-13 | 清华大学天津高端装备研究院 | 一种能够减少溶血的体外血泵 |
CN110714926A (zh) * | 2018-07-11 | 2020-01-21 | 同心医疗器械(美国)有限公司 | 具有磁悬浮叶轮的紧凑型离心泵 |
US11378090B2 (en) | 2018-07-11 | 2022-07-05 | Ch Biomedical (Usa) Inc. | Compact centrifugal pump with magnetically suspended impeller |
US10947986B2 (en) | 2018-07-11 | 2021-03-16 | Ch Biomedical (Usa) Inc. | Compact centrifugal pump with magnetically suspended impeller |
Also Published As
Publication number | Publication date |
---|---|
US20150361987A1 (en) | 2015-12-17 |
US10473105B2 (en) | 2019-11-12 |
JP7248723B2 (ja) | 2023-03-29 |
JP2019069225A (ja) | 2019-05-09 |
US20180045210A1 (en) | 2018-02-15 |
EP3636935A1 (en) | 2020-04-15 |
EP3158203A4 (en) | 2018-03-28 |
JP2021079181A (ja) | 2021-05-27 |
EP3158203B1 (en) | 2020-07-15 |
CN106574628B (zh) | 2019-12-10 |
US10030664B2 (en) | 2018-07-24 |
WO2015195233A1 (en) | 2015-12-23 |
EP3636935C0 (en) | 2024-04-24 |
JP2017518159A (ja) | 2017-07-06 |
EP3158203A1 (en) | 2017-04-26 |
EP3636935B1 (en) | 2024-04-24 |
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