CN1065435C - 一种治疗脂溢性脱发的高效低副作用的改进型外用药物 - Google Patents
一种治疗脂溢性脱发的高效低副作用的改进型外用药物 Download PDFInfo
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Abstract
本发明涉及一种治疗脂溢性脱发的高效低副作用的改进型外用药，它由何首乌，女贞子，桑椹子，生地，旱莲草，丹参，红花，蛇床子，苦参，白藓皮，地肤子与13-顺-维甲酸，加上适当的抗氧化剂和70%乙醇组成，对脂溢性脱发有很好的疗效且副作用低，可大范围普及推广应用。
Description
本发明涉及一种治疗脂溢性脱发的改进型高效低副作用药物，具体地说是一种以中草药和13-顺-维甲酸配合制成的外用药，具有高效低副作用，适宜于大范围推广应用。
脱发是一种常见多发的皮肤病，主要分为两种类型，即非脂溢性脱发(如斑脱)和脂溢性脱发。非脂溢性脱发的治疗比较容易些，已有许多有效成药。如由何首乌、桑椹子等中药制成的药物对斑秃等非脂溢性脱发就有较好的疗效。然而对于脂溢性脱发，这些药物可以说疗效甚微。脂溢性脱发的治疗可以说是皮肤医学界的一个难题，虽然人们做了许多努力，至今仍无真正有效的药物与治疗方法问世。
脂溢性脱发的本质病因目前尚不清楚，目前中医认为人体肾血亏虚西医认为雄性激素分泌过旺引起脂溢性脱发，但中医用养血补肾药物西医用抗雄性激素治疗脂溢性脱发都疗效不佳。本发明认为脂溢性脱发的直接原因是由于人体内分泌失调引起皮脂分泌过旺，而过多的皮脂中所含的某些物质如油酸、亚油酸、角鲨烯等对毛囊有毒性作用，导致毛发中毒、枯萎、脱落，即皮脂分泌过旺可能是脂溢性脱发的直接原因。因此，对脂溢性脱发真正有效的药物首先应当要能有效地抑制或降低头皮脂肪的过量分泌。
另从40年代起，就有人用维生素A来治疗痤疮，痤疮也是由于皮脂分泌过旺而此起的皮肤病，但维生素A抑制皮脂分泌的能力并不太强，且长期使用有较大的毒副作用，如头痛、骨痛、脱发等。近几十年来人们在维生素A的基础上先后合成了几百种维生素A类物质，寻找更安全有效的治疗痤疮药物。这些物质都有明显的抑制皮脂分泌的作用。然而，仅用维生素A类物质治疗脂溢性脱发也是不完整的，它不能使脱发再生。另外脂溢性脱发患者大多头皮毛囊受损严重，头皮毛细血管萎缩，导致毛发营养不良。本发明人在临床应用观察到的事实是，如果仅用维生素A类物质来治疗，许多患者的头发仍会持续出现不正常脱发，若与对毛发生长有促进作用的中药联合组方来治疗脂溢性脱发，效果会大大增强。
本发明人曾在95年申请了一种治疗脂溢性脱发的外用药配方，并已获专利(专利号为ZL95103687．4)。该配方采用13-顺-维甲酸和对毛发生长有促进作用的中药相结合来组方。本发明在于提出一种新的改进型配方，除了具有更好的去皮脂防脱发作用外，还具有更少的副作用，有利于患者接受。
本发明的药物配方组成为：
何首乌20-40克 女贞子10-20克 桑椹子10-20克 生地10-20克
旱莲草10-20克 丹参5-15克 红花5-15克 蛇床子10-30克
苦参5-15克 白藓皮5-15克 地肤子5-15克
2．6-二叔丁基对甲酚0．05-5克 13-顺-维甲酸0．05-5克 70％乙醇1000-1500毫升
制备方法是：
将上述配方中的何首乌、女贞子、桑椹子、生地、旱莲草、丹参、红花、蛇床子、苦参、白藓皮、地肤子粉碎后加70％乙醇浸泡一个星期，过滤去渣，在滤液中加入配方量的13-顺-维甲酸和抗氧化剂(2．6-二叔丁基对甲酚)，混合均匀即可制得本发明的外用药。
制备本发明的优选配方为：
何首乌30克 女贞子15克 桑椹子15克 生地15克
旱莲草15克 丹参10克 红花10克 蛇床子20克
苦参10克 白藓皮10克 地肤子10克
2．6-二叔丁基对甲酚1克 13-顺-维甲酸1克 70％醇1200毫升
制成药液1000毫升。
大量临床应用表明，本发明的外用药用于脂溢性脱发的治疗有很明确的效果，由于13-顺-维甲酸对皮脂有很强的抑制作用，患者使用几天即可感到头皮油脂明显减少，头发脱落程度大大降低，使用十几一二十天左右就可基本制止不正常脱发。同时中药何首乌、女贞子、桑椹子、生地、旱莲草中所含成份有很好的促进头发生长的作用。丹参、红花能起到活血，促进头皮血液循环，改善头皮营养输送作用。
另13-顺-维甲酸在外涂液中的浓度对控制脱发的效果有较大的影响，浓度越高去皮脂防脱发效果越强。但另一方面浓度较大时会使皮肤产生骚痒、皮疹与刺激作用，从而限制了浓度的提高。本发明者发现蛇床子、苦参、白藓皮、地肤子等中药对13-顺-维甲酸引起的皮肤骚痒、皮疹、刺激等症状有较好的抑制作用，故在外用药中加入这几种中药成份能有效地减少13-顺-维甲酸对头皮的不良副作用，从而可以大大提高外用药中13-顺-维甲酸的浓度，从而大大提高疗效。大量临床应用表明，本发明配方的疗效比本发明人95年申请的同类药物的疗效有一个较大的提高。95年申请的专利配方在夏天高温季节因13-顺-维甲酸的浓度不够，疗效明显降低(气温越高患者皮脂分泌越多)，而本发明的配方在高温季节仍能保持很好的疗效，同时有较低的副作用。因此可以说本发明的药物是一种治疗脂溢性脱发的更为理想药物，值得大规模推广应用。
维甲酸类药物的副作用主要体现在皮肤和粘膜上，在浓度较高时会引起皮肤发庠，刺激，干燥、脱屑，以及皮疹等。中药苦参，蛇床子，地肤子、白藓皮可以去庠，去皮屑、消炎、解毒，这是已知的。但苦参，蛇床子，地肤子对于由13-顺维甲酸引起的皮肤症状有消解作用，尤其是在药源副作用继续存在时有抑制消除作用，这是未见报道的。利用中药苦参，蛇床子，地肤子、白藓皮来消除13-顺维甲酸引起的皮肤症状，从而可大大提高13-顺维甲酸的浓度，使药物更为高效，这体现了本药物发明的新颖性和创造性之处。
以下给出实施例，进一步详细描述本发明：
取何首乌30克，女贞子15克，桑椹子15克，生地15克，旱莲草15克，丹参10克，红花10克，蛇床子20克，苦参10克，白藓皮10克，地肤子10克，将它们粉碎混合，加入70％乙醇1200毫升。浸泡一个星期，过滤去渣。精确量取1000毫升滤液，加入2．6-二叔丁基对甲酚1克，13-顺-维甲酸1克，溶解后混合均匀，制得本发明药液1000毫升。
Claims (3)
1．一种治疗脂溢性脱发的改进型外用药，其特征在于它由以下原料制成的外用药剂：
何首乌20-40克 女贞子10-20克 桑椹子10-20克 生地10-20克
旱莲草10-20克 丹参5-15克 红花5-15克 蛇床子10-30克
苦参5-15克 白藓皮5-15克 地肤子5-15克
2．6-二叔丁基对甲酚0．05-5克 13-顺-维甲酸0．05-5克 70％乙醇1000-1500毫升。
2．根据权利要求1所述的药物，其特征在于它是由以下原料制成的外用药剂：
何首乌30克 女贞子15克 桑椹子15克 生地15克
旱莲草15克 丹参10克 红花10克 蛇床子20克
苦参10克 白藓皮10克 地肤子10克
2．6-二叔丁基对甲酚1克 13-顺-维甲酸1克 70％乙醇1200毫升。
3．一种治疗脂溢性脱发的改进型外用药物的制备方法，其特征在于原料配比为：
何首乌20-40克 女贞子10-20克 桑椹子10-20克 生地10-20克
旱莲草10-20克 丹参5-15克 红花5-15克 蛇床子10-30克
苦参5-15克 白藓皮5-15克 地肤子5-15克
2．6-二叔丁基对甲酚0．05-5克 13-顺-维甲酸0．05-5克 70％乙醇1000-1500毫升
其加工工艺如下：将中药何首乌、女贞子、桑椹子、生地、旱莲草、丹参、红花、蛇床子、苦参、白藓皮、地肤子、按比例混合，粉碎，加入70％乙醇浸泡一个星期，过滤，取滤液，加入配方量的13-顺-维甲酸和2．6-二叔丁基对甲酚，搅拌均匀，装瓶即可制成本发明的外用药物。
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96109964A CN1065435C (zh) | 1996-08-09 | 1996-08-09 | 一种治疗脂溢性脱发的高效低副作用的改进型外用药物 |
| PCT/CN1997/000077 WO1998006412A1 (fr) | 1996-08-09 | 1997-08-01 | Medicament a usage externe destine au traitement de la seborrhee du cuir chevelu et possedant une grande efficacite et peu d'effets secondaires, et preparation de ce medicament |
| AU36914/97A AU3691497A (en) | 1996-08-09 | 1997-08-01 | A medicine of external use for treating seborrheic baldness with high efficacy and low side effect and preparation thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96109964A CN1065435C (zh) | 1996-08-09 | 1996-08-09 | 一种治疗脂溢性脱发的高效低副作用的改进型外用药物 |
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| Publication Number | Publication Date |
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| CN1150043A CN1150043A (zh) | 1997-05-21 |
| CN1065435C true CN1065435C (zh) | 2001-05-09 |
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| Country | Link |
|---|---|
| CN (1) | CN1065435C (zh) |
| AU (1) | AU3691497A (zh) |
| WO (1) | WO1998006412A1 (zh) |
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| US6261566B1 (en) * | 1999-10-22 | 2001-07-17 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Cosmetic compositions containing mulberry extract and retinoids |
| KR20030070686A (ko) * | 2002-02-26 | 2003-09-02 | 정성인 | 발모 촉진 및 탈모 예방용 외용제의 제조 방법 |
| KR100953278B1 (ko) * | 2008-02-25 | 2010-04-19 | 보령메디앙스 주식회사 | 항염 및 피부자극완화용 화장료 조성물 |
| CN111084726A (zh) * | 2020-01-08 | 2020-05-01 | 北京幸福益生再生医学科技有限公司 | 一种防脱生发组合物及其制备方法 |
| DE102022100053A1 (de) | 2022-01-03 | 2023-07-06 | Snejan Dimitrov Ivantchev | Topisches Mittel zur Behandlung von Alopecia areata (SNEZHALIN)) |
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| CN1097140A (zh) * | 1994-01-19 | 1995-01-11 | 柴瑞霞 | 主治白发及脱发的荣发丸 |
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| CN1087267A (zh) * | 1992-11-23 | 1994-06-01 | 梅晓春 | 一种治疗脂溢性脱发的配方 |
| CN1051464C (zh) * | 1994-04-14 | 2000-04-19 | 梅晓春 | 一种治疗脂溢性脱发的内服药物 |
| CN1133714A (zh) * | 1995-01-04 | 1996-10-23 | 马水旺 | 保健浴液 |
| CN1051465C (zh) * | 1995-04-11 | 2000-04-19 | 梅晓春 | 一种治疗脂溢性脱发的外用药物 |
| CN1051466C (zh) * | 1995-04-18 | 2000-04-19 | 梅晓春 | 一种治疗脂溢性脱发的外用药物 |
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| AU3691497A (en) | 1998-03-06 |
| CN1150043A (zh) | 1997-05-21 |
| WO1998006412A1 (fr) | 1998-02-19 |
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