CN106540229A - 一种治疗寒性痛病的外用药酒及其制备方法 - Google Patents
一种治疗寒性痛病的外用药酒及其制备方法 Download PDFInfo
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- CN106540229A CN106540229A CN201610975558.0A CN201610975558A CN106540229A CN 106540229 A CN106540229 A CN 106540229A CN 201610975558 A CN201610975558 A CN 201610975558A CN 106540229 A CN106540229 A CN 106540229A
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Abstract
本发明公开了一种治疗寒性痛病的外用药酒及其制备方法,本发明采用八十种中药配伍并经过浸泡、高温高压蒸、高温煮、三次发酵、过滤提纯后分批入药制成,使药材的有效成分充分融入到白酒中,该外用药酒具有暖骨、通经、理气、活血、散瘀、止痛、止痒、消肿、利湿等多种功效。本外用药酒配伍合理,针对性强,标本兼治,适用于寒性痛病的治疗,治愈率高,疗程短,疗效显著,愈后不复发,而且安全可靠,无毒副作用,治疗费用低,禁忌较少,适宜大部分人群使用等特点,使用时只需将产品涂抹在病痛处,使用方便,解决了各类寒性痛病带给人们的困扰,其市场前景广阔。
Description
技术领域
本发明属于药酒技术领域,具体涉及一种外用药酒及其制备方法,特别涉及一种治疗寒性痛病的外用药酒及其制备方法。
背景技术
据调查,世界上患有风湿痹症的病人已经超过十亿人,可见风湿痹症的发病率高、患病人群比较广泛,尤其在较寒冷地区的中老年人群中发病率更高。风寒湿是由外邪侵袭经络和气血闭阻不畅所致,主要表现症状是肢体、关节和肌肉感觉疼痛和麻木,关节屈伸不利且遇寒则痛、遇热则缓痛,肢体关节酸痛、游走不定、不拘上下左右,肢体关节沉重酸胀疼痛、关节肿胀、四肢活动不便等。现代医学将上述症状归类为:风湿病、风湿性关节炎、类风湿性关节炎、肩周炎、颈椎病、腰椎间盘突出、坐骨神经痛等。风寒湿的病因较复杂,一般多因脾虚、肝弱和肾亏所致,若脾肝肾虚弱、脾不统血、肝不养筋、肾不主骨,运化失常,则抗病能力减退,偶感风、寒、湿之邪,则滞留于肌肉经络之间,久之病变则出现。另外,现代人的不良社会习惯导致的脊柱疾病也越来越年轻化普遍化。
目前,治疗上述各类寒性疼痛脊柱骨关节疾病的常见方式多为内服抗生药、激素药和镇痛药。内服药物对肝肾和各脏器的损伤都比较大,越来越多的人已经认识到这个问题,因此人们都在寻求一种新的绿色治疗方式。外用药物即可以大大减轻药物对脏器的损伤,又可以增大药物的针对性,所以被越来越多的人所认可,外用药物分为涂含化学合成药物的药膏和贴用中药膏药二大类。涂抹合成药膏主要有抗菌制剂、皮质激素类制剂等,其疗效虽较快,但其治愈率低,费用高,停药后容易复发,且副作用大,禁忌比较多,适用人群有限;采用贴用中成膏药虽然能克服涂抹含化学合成药物的药膏带来副作用大的缺陷,但膏药贴的时间长会使皮肤透气性变差,从而导致皮肤瘙痒,另外还需要不断更换膏药,使用不方便。
发明内容
本发明的目的在于提供一种治疗寒性痛病的外用药酒,该药酒可具有暖骨、通经、理气、活血、散瘀、止痛、止痒、消肿、利湿等多种功效,使用方便,效果明显,彻底治疗后不会复发,无毒副作用,适用人群广泛。
本发明的另一目的在于提供一种上述外用药酒的制备方法,该方法可使药材中的有效成分能充分融入到白酒中,且方法简单,成本低,制作过程无污染。
为实现上述目的,本发明提供了一种治疗寒性痛病的外用药酒,由以下重量份的原料组成:附子20-30份、干姜20-30份、天南星10-20份、胡椒10-20份、川乌10-20份、草乌10-20份、花椒20-30份、小茴香20-30份、高良姜15-20份、公丁香10-20份、吴茱萸10-20份、山柰10-20份、姜黄10-20份、乳香10-20份、没药10-20份、苏木10-20份、大血藤10-20份、丝瓜络10-20份、骨碎补10-20份、延胡索20-30份、川芎20-30份、八角枫10-20份、自然铜5-10份、桃枝15-20份、五灵脂10-15份、血竭10-20份、土鳖虫10-20份、马钱子10-20份、刘寄奴10-15份、水红花子10-20份、莪术10-20份、三棱10-20份、斑蝥5-10份、鸡血藤10-20份、红花10-20份、益母草10-20份、泽兰10-20份、蚂蚁窝10-20份、马鞭草5-10份、桃仁5-10份、芥子20-30份、丹参10-20份、牛膝10-20份、川牛膝10-20份、山甲片10-15份、水蛭10-15份、麻黄10-15份、防己10-20份、徐长卿10-15份、桑白皮10-20份、路路通20-30份、细辛10-20份、樟脑10-15份、冰片5-10份、安息香10-20份、石菖蒲10-20份、麝香2-10份、蟾酥10-15份、杜仲20-30份、红景天10-20份、肉桂10-20份、蛇床子10-20份、韭菜子10-15份、胡芦巴10-20份、补骨脂10-20份、巴戟天10-15份、续断10-20份、当归10-20份、秦艽10-20份、羌活10-20份、独活10-20份、松节20-30份、乌梢蛇10-20份、雷公藤20-30份、伸筋草20-30份、寻骨风20-30份、丁公藤10-20份、狗脊20-30份、小驳骨10-20份、沉香5-10份、50°以上的白酒1000-2000份。
优选的,所述治疗寒性痛病的外用药酒由以下重量份的原料组成:附子22-28份、干姜22-28份、天南星12-18份、胡椒12-18份、川乌12-18份、草乌12-18份、花椒22-28份、小茴香22-28份、高良姜16-18份、公丁香12-18份、吴茱萸12-18份、山柰12-18份、姜黄12-18份、乳香12-18份、没药12-18份、苏木12-18份、大血藤12-18份、丝瓜络12-18份、骨碎补13-19份、延胡索22-28份、川芎24-28份、八角枫12-18份、自然铜6-8份、桃枝16-18份、五灵脂12-14份、血竭12-18份、土鳖虫12-18份、马钱子16-18份、刘寄奴12-14份、水红花子12-18份、莪术12-18份、三棱12-18份、斑蝥6-8份、鸡血藤13-19份、红花12-18份、益母草12-18份、泽兰12-18份、蚂蚁窝12-18份、马鞭草6-8份、桃仁6-8份、芥子23-27份、丹参12-18份、牛膝12-18份、川牛膝12-18份、山甲片12-14份、水蛭12-14份、麻黄12-14份、防己12-18份、徐长卿12-14份、桑白皮12-18份、路路通22-28份、细辛13-17份、樟脑12-14份、冰片6-8份、安息香12-18份、石菖蒲14-18份、麝香5-7份、蟾酥12-14份、杜仲22-28份、红景天12-18份、肉桂12-18份、蛇床子12-18份、韭菜子12-14份、胡芦巴12-18份、补骨脂12-18份、巴戟天12-14份、续断14-18份、当归15-19份、秦艽12-18份、羌活12-18份、独活14-18份、松节22-28份、乌梢蛇13-17份、雷公藤23-29份、伸筋草21-27份、寻骨风22-28份、丁公藤12-18份、狗脊23-29份、小驳骨12-18份、沉香6-8份、50°以上的白酒1400-1800份。
优选的,所述治疗寒性痛病的外用药酒由以下重量份的原料组成:附子25份、干姜25份、天南星15份、胡椒15份、川乌15份、草乌15份、花椒25份、小茴香25份、高良姜17份、公丁香15份、吴茱萸15份、山柰15份、姜黄15份、乳香15份、没药15份、苏木15份、大血藤15份、丝瓜络15份、骨碎补16份、延胡索25份、川芎26份、八角枫15份、自然铜7份、桃枝17份、五灵脂13份、血竭15份、土鳖虫15份、马钱子17份、刘寄奴13份、水红花子15份、莪术15份、三棱15份、斑蝥7份、鸡血藤16份、红花15份、益母草15份、泽兰15份、蚂蚁窝15份、马鞭草7份、桃仁7份、芥子25份、丹参15份、牛膝15份、川牛膝15份、山甲片13份、水蛭13份、麻黄13份、防己15份、徐长卿13份、桑白皮15份、路路通25份、细辛15份、樟脑13份、冰片7份、安息香15份、石菖蒲16份、麝香6份、蟾酥13份、杜仲25份、红景天15份、肉桂15份、蛇床子15份、韭菜子13份、胡芦巴15份、补骨脂15份、巴戟天13份、续断16份、当归17份、秦艽15份、羌活15份、独活16份、松节25份、乌梢蛇15份、雷公藤26份、伸筋草24份、寻骨风25份、丁公藤15份、狗脊26份、小驳骨15份、沉香7份、50°以上的白酒1600份。
一种治疗寒性痛病的外用药酒的制备方法,其特征在于,包括以下步骤:
(1)备料:将中药原料按重量份称重,洗净,晒干备用;
(2)浸泡:将外壳坚硬的中药原料放入水中浸泡23~25h,所述中药原料中油脂类、挥发类药物不参与浸泡;
(3)蒸:将经过步骤(2)浸泡后的中药原料在105~115℃和130~140kPa的高温高压下蒸1.5~2.5h;
(4)煮:将经过步骤(3)高温高压蒸后的原材料放到锅里用纯净水煮沸0.8~1.2h后放入外壳柔软的易煮中药原料,继续煮0.8~1.2h;
(5)发酵:将经过步骤(4)处理后的中药原料加蒸煮液体一起放入装有白酒的密封罐内进行第一次发酵,每隔5~7天搅拌一次,2个月后向密封罐内加入油脂类和挥发类药物并搅拌均匀密封后进行第二次发酵,再经过2个月后向密封罐内加入麝香和沉香并搅拌均匀密封后进行第三次发酵,再经过2个月后完成发酵过程;所述发酵环境为干燥、阴凉、通风;
(6)过滤提纯:将经过步骤(5)后的药物经过过滤去除固体药材,再将剩余的原液静置一周后进行提纯得到治疗寒性痛症病的外用药酒。
本发明原料的药理药性及功效如下:
附子:辛、大热;回阳补火、逐火寒湿;
干姜:辛、温;祛寒温中、回阳;
天南星:性温、味苦;燥湿化痰、祛风止痉、散结消肿;
胡椒:辛、热;除阴寒、暖肠胃止痛、下气消痰;
川乌:辛、苦、热;辛热苦燥、善于驱逐寒湿、温经止痛;
草乌:性热、味辛、苦;祛风除湿、温经止痛;
花椒:辛、温;散寒除湿发汗、通血脉、暖胃消食;
小茴香:辛、温;补阳散寒、理气开胃、止呕;
高良姜:辛、热;畏寒作痛、呕吐噫气;
公丁香:辛、温;温中壮阳、下气降逆;
吴茱萸:辛、苦、大热;疏肝下气、温中散寒、燥湿助阳;
山柰:辛、温;温中消食止痛;
姜黄:辛、苦、温;行气破瘀、通经;
乳香:苦、辛、温;活血止痛、消肿生肌;
没药:苦、辛、平;散血止痛,消肿生肌;
苏木:甘、咸、辛凉;行血祛瘀、消肿止痛;
大血藤:苦、平;败毒消痈、活血通络、祛风杀虫;
丝瓜络:甘、平;清热解毒、活血通络、利尿消肿;
骨碎补:苦、温;补肝肾、续筋骨、活血止痛;
延胡索:辛、苦、温;活血、理气、止痛;
川芎:辛、温;活血行气、祛风止痛;
八角枫:辛、温;祛风、通络散瘀、镇痛、麻醉及松弛肌肉;
自然铜:辛、平;散瘀止痛、续筋接骨;
桃枝:味苦、治心腹痛及匿疮;
五灵脂:甘、温;散瘀、行血、止痛;
血竭:甘、咸、平;活血止痛、散瘀生新;
土鳖虫:咸、寒;破瘀血、通经;
马钱子:苦、寒;祛风定痛、舒筋活络、散血热、消肿毒;
刘寄奴:苦、温;祛瘀通经、消化食积;
水红花子:咸、寒;消瘀破积、健脾利湿;
莪术:苦、辛、温;行气破血、消积止痛;
三棱:苦、平;破血行气、消积止痈;
斑蝥:辛、寒;攻毒、逐瘀;
鸡血藤:苦、温。补血行血、通经络、强筋骨;
红花:辛、温。破瘀、活血、通经;
益母草:辛、苦、微寒;祛瘀生新、活血调经、利尿;
泽兰:苦、微温;活血通经、行水;
蚂蚁窝:补肾、抗风湿、强筋骨、抗癌;所述蚂蚁窝是特种大蚂蚁的唾液粘合起来的;
马鞭草:性凉、味微苦;通经、散瘀、清热、解毒、止痒;
芥子:辛、热;温中散寒、利气豁痰、通经络、消肿毒;
桃仁:苦、甘、平;活血行瘀,润燥滑肠;
丹参:苦、微寒;活血通络、凉血消肿、除烦清心;
牛膝:苦、酸、平。补肝肾、强腰膝、破血行瘀;
川牛膝:平、甘、微苦;祛风、利湿、通经、活血;
山甲片:咸、微寒;消肿溃痈、通经下乳、通络散风;
水蛭:咸、苦、平;通经、破瘀、消肿;
麻黄:辛、苦、温;发汗、平喘、利尿;
防己:性寒、味苦;利水消肿、祛风止痛;
徐长卿:性温、味辛;祛风化湿、行气通络;
桑白皮:甘、寒;泻肺平喘、行水消肿;
路路通:苦、微涩、平;通经、利水、除湿热痹痛;
细辛:辛、温;散风祛寒、通窍止痛、下气祛痰;
樟脑:辛、热杀虫;止痒、消肿止痛、辟秽开窍;
冰片:辛、苦,微寒;开窍醒脑、清热消肿;
安息香:辛、苦、平;开窍、辟恶、散风、行血;
石菖蒲:辛、微温;开窍豁痰、理气活血、散风去湿;
麝香:辛、温;开窍、辟秽、通络、散瘀;
蟾酥:辛,温;解毒,止痛,开窍醒神;
杜仲:性温、味甘;补肝肾、强筋骨;
红景天:性平、味甘、苦;益气活血、通脉平喘;
肉桂:性大热、味辛、甘;补火助阳、引火归元、止痛通经;蛇床子:性温、味辛、苦;温肾壮阳、燥湿、祛风;
韭菜子:性温、味辛、甘;温补肝肾、壮阳固精;
胡芦巴:性温、味苦;温肾、祛寒、止痛;
补骨脂:性温、味辛、苦;温肾助阳、纳气、止泻;
巴戟天:性微温、味甘、辛;补肾阳、强筋骨、祛风湿;
续断:性微温、味苦、辛;补肝肾、强筋骨、续折伤;
当归:性温、味甘、辛;补血活血、调经止痛;
秦艽:性平、味苦、辛;祛风湿、退虚热、舒筋止疼;
羌活:性温、味辛、苦;解表散寒、祛风除湿、止痛;
独活:性微温、味辛、苦;祛风除湿、通痹止痛;
松节:苦、温;为祛风燥湿、止痛;
乌梢蛇:性平、味甘;祛风、通络、止痉;
雷公藤:性凉、味苦、辛;祛风除湿、活血通络、消肿止痛、消炎、解毒;
伸筋草:性温、味微苦、辛;祛风寒、除湿消肿、舒筋活络;
寻骨风:性平、味辛、苦;祛风通络、行气止痛;
丁公藤:性温、味辛;祛风除湿、消肿止痛;
狗脊:性温、味苦、甘;补肝肾、强腰膝、祛风湿;
小驳骨:性温、味辛;祛瘀止痛、续筋接骨;
沉香:辛、苦、温;降气温中,暖肾纳气;
白酒:50°以上,能够促进血液循环。
本发明采用八十种中药配伍并经过浸泡、高温高压蒸、高温煮、三次发酵、过滤提纯后分批入药制成,使药材的有效成分充分融入到白酒中,该外用药酒具有暖骨、通经、理气、活血、散瘀、止痛、止痒、消肿、利湿等多种功效。本外用药酒配伍合理,针对性强,标本兼治,适用于寒性痛病的治疗,治愈率高,疗程短,疗效显著,愈后不复发,而且安全可靠,无毒副作用,治疗费用低,禁忌较少,适宜大部分人群使用等特点,使用时只需将产品涂抹在病痛处,使用方便,解决了各类寒性痛病带给人们的困扰,其市场前景广阔。
具体实施方式
以下结合具体实施例对本发明作进一步详细说明。
实施例一
一种治疗寒性痛病的外用药酒,由以下重量份的原料组成:附子20份、干姜20份、天南星10份、胡椒10份、川乌10份、草乌10份、花椒20份、小茴香20份、高良姜15份、公丁香10份、吴茱萸10份、山柰10份、姜黄10份、乳香10份、没药10份、苏木10份、大血藤10份、丝瓜络10份、骨碎补10份、延胡索20份、川芎20份、八角枫10份、自然铜5份、桃枝15份、五灵脂10份、血竭10份、土鳖虫10份、马钱子10份、刘寄奴10份、水红花子10份、莪术10份、三棱10份、斑蝥5份、鸡血藤10份、红花10份、益母草10份、泽兰10份、蚂蚁窝10份、马鞭草5份、桃仁5份、芥子20份、丹参10份、牛膝10份、川牛膝10份、山甲片10份、水蛭10份、麻黄10份、防己10份、徐长卿10份、桑白皮10份、路路通20份、细辛10份、樟脑10份、冰片5份、安息香10份、石菖蒲10份、麝香2份、蟾酥10份、杜仲20份、红景天10份、肉桂10份、蛇床子10份、韭菜子10份、胡芦巴10份、补骨脂10份、巴戟天10份、续断10份、当归10份、秦艽10份、羌活10份、独活10份、松节20份、乌梢蛇10份、雷公藤20份、伸筋草20份、寻骨风20份、丁公藤10份、狗脊20份、小驳骨10份、沉香5份、50°以上的白酒1000份。
一种治疗寒性痛病的外用药酒的制备方法,包括以下步骤:
(1)备料:将中药原料按重量份称重,洗净,晒干备用;
(2)浸泡:将外壳坚硬的中药原料放入水中浸泡23~25h,所述中药原料中油脂类、挥发类药物不参与浸泡;
(3)蒸:将经过步骤(2)浸泡后的中药原料在105~115℃和130~140kPa的高温高压下蒸1.5~2.5h;
(4)煮:将经过步骤(3)高温高压蒸后的原材料放到锅里用纯净水煮沸0.8~1.2h后放入外壳柔软的易煮中药原料,继续煮0.8~1.2h;
(5)发酵:将经过步骤(4)处理后的中药原料加蒸煮液体一起放入装有白酒的密封罐内进行第一次发酵,每隔5~7天搅拌一次,2个月后向密封罐内加入油脂类和挥发类药物并搅拌均匀密封后进行第二次发酵,再经过2个月后向密封罐内加入麝香和沉香并搅拌均匀密封后进行第三次发酵,再经过2个月后完成发酵过程;所述发酵环境为干燥、阴凉、通风;
(6)过滤提纯:将经过步骤(5)后的药物经过过滤去除固体药材,再将剩余的原液静置一周后进行提纯得到治疗寒性痛症病的外用药酒。
实施例二
一种治疗寒性痛病的外用药酒,由以下重量份的原料组成:附子30份、干姜30份、天南星20份、胡椒20份、川乌20份、草乌20份、花椒30份、小茴香30份、高良姜20份、公丁香20份、吴茱萸20份、山柰20份、姜黄20份、乳香20份、没药20份、苏木20份、大血藤20份、丝瓜络20份、骨碎补20份、延胡索30份、川芎30份、八角枫20份、自然铜10份、桃枝20份、五灵脂15份、血竭20份、土鳖虫20份、马钱子20份、刘寄奴15份、水红花子20份、莪术20份、三棱20份、斑蝥10份、鸡血藤20份、红花20份、益母草20份、泽兰20份、蚂蚁窝20份、马鞭草10份、桃仁10份、芥子30份、丹参20份、牛膝20份、川牛膝20份、山甲片15份、水蛭15份、麻黄15份、防己20份、徐长卿15份、桑白皮20份、路路通30份、细辛20份、樟脑15份、冰片10份、安息香20份、石菖蒲20份、麝香10份、蟾酥15份、杜仲30份、红景天20份、肉桂20份、蛇床子20份、韭菜子15份、胡芦巴20份、补骨脂20份、巴戟天15份、续断20份、当归20份、秦艽20份、羌活20份、独活20份、松节30份、乌梢蛇20份、雷公藤30份、伸筋草30份、寻骨风30份、丁公藤20份、狗脊30份、小驳骨20份、沉香10份、50°以上的白酒2000份。
制备方法与实施例一相同。
实施例三
一种治疗寒性痛病的外用药酒,由以下重量份的原料组成:附子22份、干姜22份、天南星12份、胡椒12份、川乌12份、草乌12份、花椒22份、小茴香22份、高良姜16份、公丁香12份、吴茱萸12份、山柰12份、姜黄12份、乳香12份、没药12份、苏木12份、大血藤12份、丝瓜络12份、骨碎补13份、延胡索22份、川芎24份、八角枫12份、自然铜6份、桃枝16份、五灵脂12份、血竭12份、土鳖虫12份、马钱子16份、刘寄奴12份、水红花子12份、莪术12份、三棱12份、斑蝥6份、鸡血藤13份、红花12份、益母草12份、泽兰12份、蚂蚁窝12份、马鞭草6份、桃仁6份、芥子23份、丹参12份、牛膝12份、川牛膝12份、山甲片12份、水蛭12份、麻黄12份、防己12份、徐长卿12份、桑白皮12份、路路通22份、细辛13份、樟脑12份、冰片6份、安息香12份、石菖蒲14份、麝香5份、蟾酥12份、杜仲22份、红景天12份、肉桂12份、蛇床子12份、韭菜子12份、胡芦巴12份、补骨脂12份、巴戟天12份、续断14份、当归15份、秦艽12份、羌活12份、独活14份、松节22份、乌梢蛇13份、雷公藤23份、伸筋草21份、寻骨风22份、丁公藤12份、狗脊23份、小驳骨12份、沉香6份、50°以上的白酒1400份。
制备方法与实施例一相同。
实施例四
一种治疗寒性痛病的外用药酒,由以下重量份的原料组成:附子28份、干姜28份、天南星18份、胡椒18份、川乌18份、草乌18份、花椒28份、小茴香28份、高良姜18份、公丁香18份、吴茱萸18份、山柰18份、姜黄18份、乳香18份、没药18份、苏木18份、大血藤18份、丝瓜络18份、骨碎补19份、延胡索28份、川芎28份、八角枫18份、自然铜8份、桃枝18份、五灵脂14份、血竭18份、土鳖虫18份、马钱子18份、刘寄奴14份、水红花子18份、莪术18份、三棱18份、斑蝥8份、鸡血藤19份、红花18份、益母草18份、泽兰18份、蚂蚁窝18份、马鞭草8份、桃仁8份、芥子27份、丹参18份、牛膝18份、川牛膝18份、山甲片14份、水蛭14份、麻黄14份、防己18份、徐长卿14份、桑白皮18份、路路通28份、细辛17份、樟脑14份、冰片8份、安息香18份、石菖蒲18份、麝香7份、蟾酥14份、杜仲28份、红景天18份、肉桂18份、蛇床子18份、韭菜子14份、胡芦巴18份、补骨脂18份、巴戟天14份、续断18份、当归19份、秦艽18份、羌活18份、独活18份、松节28份、乌梢蛇17份、雷公藤29份、伸筋草27份、寻骨风28份、丁公藤18份、狗脊29份、小驳骨18份、沉香8份、50°以上的白酒1800份。
制备方法与实施例一相同。
实施例五
一种治疗寒性痛病的外用药酒,由以下重量份的原料组成:附子25份、干姜25份、天南星15份、胡椒15份、川乌15份、草乌15份、花椒25份、小茴香25份、高良姜17份、公丁香15份、吴茱萸15份、山柰15份、姜黄15份、乳香15份、没药15份、苏木15份、大血藤15份、丝瓜络15份、骨碎补16份、延胡索25份、川芎26份、八角枫15份、自然铜7份、桃枝17份、五灵脂13份、血竭15份、土鳖虫15份、马钱子17份、刘寄奴13份、水红花子15份、莪术15份、三棱15份、斑蝥7份、鸡血藤16份、红花15份、益母草15份、泽兰15份、蚂蚁窝15份、马鞭草7份、桃仁7份、芥子25份、丹参15份、牛膝15份、川牛膝15份、山甲片13份、水蛭13份、麻黄13份、防己15份、徐长卿13份、桑白皮15份、路路通25份、细辛15份、樟脑13份、冰片7份、安息香15份、石菖蒲16份、麝香6份、蟾酥13份、杜仲25份、红景天15份、肉桂15份、蛇床子15份、韭菜子13份、胡芦巴15份、补骨脂15份、巴戟天13份、续断16份、当归17份、秦艽15份、羌活15份、独活16份、松节25份、乌梢蛇15份、雷公藤26份、伸筋草24份、寻骨风25份、丁公藤15份、狗脊26份、小驳骨15份、沉香7份、50°以上的白酒1600份。
制备方法与实施例一相同。
临床报告
将患者分为治疗组和对照组,治疗组采用本发明实施例五中的药酒,对照组采用涂抹合成药膏,均为早晚各涂抹一次,治疗时间为两个月,治疗组与对照组都采用100例,其中男性患者64例,女性患者36例,按照年龄段,每个组又分为两个年龄段,中年组(36—50岁)42例,老年组(51—70岁)58例。两组病例的病程、症状轻重程度等,综合平均后无显著性差异,各组之间有可比性。两组病例均于用药后第1周、第2周、第1个月、第2个月观察主要症状和体征。
疗效的判断标准,采用Huskisson提出的百分计分法,即直观模拟疼痛标度尺(VAPS),即用100毫米直线,一端为无痛,另一端为最疼。病人定期在该日的同一时间在线上标出疼痛的程度。结合临床实际,疗效分基本治愈、显效、有效和无效。疗效具体标准如下:
基本治愈:疼痛症状消失,VAPS小于20;
显效:疼痛症状明显减轻,VAPS在20-50间;
有效:疼痛症状减轻,VAPS在51-80间;
无效:疼痛症状减轻小明显,VAPS在80以上。
疗效一览表如表1:
表1:疗效一览表
从上表可以看出,治疗组的总有效率为95%,对照组的总有效率为78%。治疗组的有效率与对照组相比有明显效果。治疗组的治愈率为71%,对照组的治愈率为53%。治疗组的治愈率与对照组相比有显著性效果。
治疗组中的治愈病例,半年、1年后分别作回访,均无复发。综上所述,木发明之药物的治疗效果明显优于对照组。
典型病例:
病例1:李某,男,现年59岁,长期从事海产品的加工工作,患有腰、颈椎骨质增生,2008年因病情加重而住院治疗,半月后因病情缓解而出院继续工作,2010年病情进一步加重。其主要症状为:面色萎黄,舌苔胖嫩有齿印,脉细弦,腰痛,左腿不能伸屈,形寒肢冷,天阴则剧,夜间痛甚,纳差腹胀,下肢微肿,生活不能完全自理,涂抹本发明的药酒一个月后,即有了明显的效果,继续涂抹了两个月,痊愈,随访至今没有复发。
病例2:张某,女,现年53岁。全身关节痛多年,手指屈伸不利,行走困难,阴天酸痛,曾吃过多西药及中药,只是暂时缓解,均没有根治,遇到不良天气就会复发。2011年6月涂抹本发明的药酒一个月后,病情即有较好的转变,又连续涂抹了两个月,痊愈,随访至今没有复发。
病例3:董某,女,现年62岁。患颈椎增生多年,腿关节及脚关节痛疼二十余年,期间经常贴膏药、吃西药、中药,均不见明显好转,2011年2月开始涂抹本发明的药酒,一个月后,即可见明显好转,又连续涂抹了两个月,痊愈,随访至今没有复发。
病例4:彭某,男,现年55岁。腰腿痛10余年,腿经常有麻木的感觉,腰、腿、脚均发凉,近二年来,颈肩痛,左侧手臂麻木,手臂及手均发凉,天气稍凉就感到很冷,其舌苔淡红,脉沉细,曾进行过理疗治疗,但没有痊愈,遇到雨天或气温下降时,又会复发。2011年8月开始涂抹本发明的药酒,一个月后,症状明显好转,又连续涂抹了两个月,痊愈,随访至今没有复发。
病例5:张某,女40岁。来诊时腰肩及右腿疼痛麻木发凉7年余,尤以有骼关节、髋关节痛甚,遇冷加剧,晨起时疼痛加重,肢体活动不灵活,活动量逐渐减轻。曾吃过多西药及中药,只是暂时缓解,均没有根治,遇到雨天或气温下降时,又会复发。2011年6月开始涂抹本发明的药酒,一个月后,症状明显好转,又连续涂抹了两个月,痊愈,随访至今没有复发。
Claims (4)
1.一种治疗寒性痛病的外用药酒,其特征在于,由以下重量份的原料组成:附子20-30份、干姜20-30份、天南星10-20份、胡椒10-20份、川乌10-20份、草乌10-20份、花椒20-30份、小茴香20-30份、高良姜15-20份、公丁香10-20份、吴茱萸10-20份、山柰10-20份、姜黄10-20份、乳香10-20份、没药10-20份、苏木10-20份、大血藤10-20份、丝瓜络10-20份、骨碎补10-20份、延胡索20-30份、川芎20-30份、八角枫10-20份、自然铜5-10份、桃枝15-20份、五灵脂10-15份、血竭10-20份、土鳖虫10-20份、马钱子10-20份、刘寄奴10-15份、水红花子10-20份、莪术10-20份、三棱10-20份、斑蝥5-10份、鸡血藤10-20份、红花10-20份、益母草10-20份、泽兰10-20份、蚂蚁窝10-20份、马鞭草5-10份、桃仁5-10份、芥子20-30份、丹参10-20份、牛膝10-20份、川牛膝10-20份、山甲片10-15份、水蛭10-15份、麻黄10-15份、防己10-20份、徐长卿10-15份、桑白皮10-20份、路路通20-30份、细辛10-20份、樟33脑10-15份、冰片5-10份、安息香10-20份、石菖蒲10-20份、麝香2-10份、蟾酥10-15份、杜仲20-30份、红景天10-20份、肉桂10-20份、蛇床子10-20份、韭菜子10-15份、胡芦巴10-20份、补骨脂10-20份、巴戟天10-15份、续断10-20份、当归10-20份、秦艽10-20份、羌活10-20份、独活10-20份、松节20-30份、乌梢蛇10-20份、雷公藤20-30份、伸筋草20-30份、寻骨风20-30份、丁公藤10-20份、狗脊20-30份、小驳骨10-20份、沉香5-10份、50°以上的白酒1000-2000份。
2.根据权利要求1所述的一种治疗寒性痛病的外用药酒,其特征在于,由以下重量份的原料组成:附子22-28份、干姜22-28份、天南星12-18份、胡椒12-18份、川乌12-18份、草乌12-18份、花椒22-28份、小茴香22-28份、高良姜16-18份、公丁香12-18份、吴茱萸12-18份、山柰12-18份、姜黄12-18份、乳香12-18份、没药12-18份、苏木12-18份、大血藤12-18份、丝瓜络12-18份、骨碎补13-19份、延胡索22-28份、川芎24-28份、八角枫12-18份、自然铜6-8份、桃枝16-18份、五灵脂12-14份、血竭12-18份、土鳖虫12-18份、马钱子16-18份、刘寄奴12-14份、水红花子12-18份、莪术12-18份、三棱12-18份、斑蝥6-8份、鸡血藤13-19份、红花12-18份、益母草12-18份、泽兰12-18份、蚂蚁窝12-18份、马鞭草6-8份、桃仁6-8份、芥子23-27份、丹参12-18份、牛膝12-18份、川牛膝12-18份、山甲片12-14份、水蛭12-14份、麻黄12-14份、防己12-18份、徐长卿12-14份、桑白皮12-18份、路路通22-28份、细辛13-17份、樟脑12-14份、冰片6-8份、安息香12-18份、石菖蒲14-18份、麝香5-7份、蟾酥12-14份、杜仲22-28份、红景天12-18份、肉桂12-18份、蛇床子12-18份、韭菜子12-14份、胡芦巴12-18份、补骨脂12-18份、巴戟天12-14份、续断14-18份、当归15-19份、秦艽12-18份、羌活12-18份、独活14-18份、松节22-28份、乌梢蛇13-17份、雷公藤23-29份、伸筋草21-27份、寻骨风22-28份、丁公藤12-18份、狗脊23-29份、小驳骨12-18份、沉香6-8份、50°以上的白酒1400-1800份。
3.根据权利要求1或2所述的一种治疗寒性痛病的外用药酒,其特征在于,由以下重量份的原料组成:附子25份、干姜25份、天南星15份、胡椒15份、川乌15份、草乌15份、花椒25份、小茴香25份、高良姜17份、公丁香15份、吴茱萸15份、山柰15份、姜黄15份、乳香15份、没药15份、苏木15份、大血藤15份、丝瓜络15份、骨碎补16份、延胡索25份、川芎26份、八角枫15份、自然铜7份、桃枝17份、五灵脂13份、血竭15份、土鳖虫15份、马钱子17份、刘寄奴13份、水红花子15份、莪术15份、三棱15份、斑蝥7份、鸡血藤16份、红花15份、益母草15份、泽兰15份、蚂蚁窝15份、马鞭草7份、桃仁7份、芥子25份、丹参15份、牛膝15份、川牛膝15份、山甲片13份、水蛭13份、麻黄13份、防己15份、徐长卿13份、桑白皮15份、路路通25份、细辛15份、樟脑13份、冰片7份、安息香15份、石菖蒲16份、麝香6份、蟾酥13份、杜仲25份、红景天15份、肉桂15份、蛇床子15份、韭菜子13份、胡芦巴15份、补骨脂15份、巴戟天13份、续断16份、当归17份、秦艽15份、羌活15份、独活16份、松节25份、乌梢蛇15份、雷公藤26份、伸筋草24份、寻骨风25份、丁公藤15份、狗脊26份、小驳骨15份、沉香7份、50°以上的白酒1600份。
4.根据权利要求1至3中任一项权利要求所述的一种治疗寒性痛病的外用药酒的制备方法,其特征在于,包括以下步骤:
(1)备料:将中药原料按重量份称重,洗净,晒干备用;
(2)浸泡:将外壳坚硬的中药原料放入水中浸泡23~25h,所述中药原料中油脂类、挥发类药物不参与浸泡;
(3)蒸:将经过步骤(2)浸泡后的中药原料在105~115℃和130~140kPa的高温高压下蒸1.5~2.5h;
(4)煮:将经过步骤(3)高温高压蒸后的原材料放到锅里用纯净水煮沸0.8~1.2h后放入外壳柔软的易煮中药原料,继续煮0.8~1.2h;
(5)发酵:将经过步骤(4)处理后的中药原料加蒸煮液体一起放入装有白酒的密封罐内进行第一次发酵,每隔5~7天搅拌一次,2个月后向密封罐内加入油脂类和挥发类药物并搅拌均匀密封后进行第二次发酵,再经过2个月后向密封罐内加入麝香和沉香并搅拌均匀密封后进行第三次发酵,再经过2个月后完成发酵过程;所述发酵环境为干燥、阴凉、通风;
(6)过滤提纯:将经过步骤(5)后的药物经过过滤去除固体药材,再将剩余的原液静置一周后进行提纯得到治疗寒性痛症病的外用药酒。
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