CN106492151A - A kind of Chinese medicine composition for treating colitis - Google Patents

A kind of Chinese medicine composition for treating colitis Download PDF

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CN106492151A
CN106492151A CN201610934562.2A CN201610934562A CN106492151A CN 106492151 A CN106492151 A CN 106492151A CN 201610934562 A CN201610934562 A CN 201610934562A CN 106492151 A CN106492151 A CN 106492151A
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radix
parts
colitis
chinese medicine
medicine composition
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张志明
雍文兴
李娟�
王鑫
刘颖
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9068Zingiber, e.g. garden ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285Aucklandia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714Aconitum (monkshood)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/889Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
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Abstract

It is an object of the invention to provide a kind of Chinese medicine composition for treating colitis.Chinese medicine composition is made up of Radix Aconiti Lateralis Preparata, Rhizoma Zingiberiss, Radix Ginseng Rubra, Radix et Rhizoma Rhei (stir-fried with wine), Semen Arecae, the Radix Aucklandiae, the Radix Pulsatillae and Radix Glycyrrhizae.It is contemplated that blocking colitis reaction, by " Wen Qing develops simultaneously, Wen Yun does not forget Qinghua, Qinghua is when must logical drop " Therapeutic Principle, spleen kidney is preferably mended, damp and hot preferably clear, damp and hot in intestinal, giving treatment in accordance with the tendency of pathological change, palpus treating incontinent symptoms (pseudomorph) by dredging method, asthenia of both the spleen and kidney, palpus the kidney invigorating cold expelling, spleen invigorating dehumidifies, propose the Chinese medicine composition for the treatment of colitis, all medicine phases 5, Wen Qing develops simultaneously, cold and heat mutually help, mend and do not help heat, clear not impairment of YANG, the clinic that uses, produce effects rather good, its clinical effectiveness is better than existing medicine, easy, effectively, have no toxic side effect, without drug dependence, clinical treatment to colitis is significant.

Description

A kind of Chinese medicine composition for treating colitis
Technical field
The invention belongs to the field of Chinese medicines, and in particular to a kind of Chinese medicine composition for treating colitis.
Background technology
Colitis refer to that the colitis that a variety of causes causes become, main clinical manifestation is diarrhoea, stomachache, abdominal distension and Bloody purulent stool, tenesmus.This sick many recurrent exerbation, does not recover for a long time.In recent years, this sick sickness rate is gone up year by year in developing country Rise, be also commonly encountered diseases in China.Doctor trained in Western medicine adjusts the methods such as immunologic function and treats this disease, clinical efficacy by blocking inflammatory reaction Not good enough.
Content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for treating colitis.
The technical scheme is that:A kind of Chinese medicine composition for treating colitis, its original by following weight Material is made:Radix Aconiti Lateralis Preparata 3-9 parts, Rhizoma Zingiberiss 3-9 parts, Radix Ginseng Rubra 5-10 parts, Radix et Rhizoma Rhei (stir-fried with wine) 3-9 parts, Semen Arecae 9-12 parts, Radix Aucklandiae 9-15 parts, white Head father-in-law 6-12 parts and Radix Glycyrrhizae 3-9 parts.
In order to further realize that the present invention, the weight of each raw material be:6 parts of Radix Aconiti Lateralis Preparata, 6 parts of Rhizoma Zingiberiss, 5 parts of Radix Ginseng Rubra, 6 parts of 6 parts of Radix et Rhizoma Rhei (stir-fried with wine), 9 parts of Semen Arecae, 10 parts of the Radix Aucklandiae, 9 parts of the Radix Pulsatillae and Radix Glycyrrhizae.
In order to further realize the present invention, water decoction, pill is made from it(Including the watered pill, honeyed pill, dragee, soft gelatin capsule, intestinal Molten ball or drop pill), medicinal tea, oral liquid, tablet, capsule, granule, unguentum or powder preparation formulation.
The Chinese medicine composition of the treatment colitis that the present invention is provided has advantages below:
1st, composition principle and cure mechanism:
Colitis refer to that the colitis that a variety of causes causes become, and main clinical manifestation is diarrhoea, stomachache, abdominal distension and pus and blood Just, tenesmus.This sick many recurrent exerbation, does not recover for a long time.Doctor trained in Western medicine adjusts the methods such as immunologic function and controls by blocking inflammatory reaction This disease is treated, clinical efficacy is not good enough.By determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, multipotency receives effective the traditional Chinese medical science.According to colitis clinical feature, Chinese medicine will Which belongs to " having loose bowels " category.《Jing Yue's complete work》Cloud:" having loose bowels originally, invariably due to taste ".The spleen and stomach provide the material basis of the acquired, mechanism of qi liter The pivot of drop, master receive digesting and absorbing the essence of foodstuff, if taste virtual loss, clear sun is difficult to inspire, and ascending or descending movement of vital Qi is unfavorable, and whether the liter or not, should go up anti-under so that Received dereliction of duty, failure of the spleen to transport and transform, water instead for wet, paddy instead for stagnant, humidity hysteresis internal resistance and life is had loose bowels.With the passing of time humidity hysteresis, is stranded and holds back spleen sun, damages spleen Gas, clear sun more fall into, and humidity hysteresis is more contained.
Radix Aconiti Lateralis Preparata:Pungent, sweet, extremely hot in nature;Poisonous.GUIXIN, kidney, spleen channel.There is recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang is wet by wind and cold Evil effect.Collapse for YANG-depletion, cold weak pulse of limb, sexual impotence, cold womb, trusted subordinate's crymodynia, cold of insufficiency type vomiting and diarrhea, cold sensation of the genitalia oedema, deficiency of yang diseases caused by external factors, Arthralgia due to cold-dampnes.
Rhizoma Zingiberiss:Pungent, property heat.Returns spleen, stomach, kidney, the heart, lung meridian.There is warming spleen and stomach for dispelling cold, Back to Yang Tongmai, warming the lung to resolve fluid-retention. For suffering from abdominal pain, vomiting is had loose bowels;Yang depletion syndrome;Cold fluid-retention is breathed with cough.
Radix Ginseng Rubra:Sweet, slight bitter, warm in nature.Returns spleen, lung, heart channel.There is strongly invigorating primordial QI, veins takes off admittedly, effect of nourishing qi to stop. For weak body and prostration, cold weak pulse of limb, QI failing to control blood, metrostaxiss;Heart failure, cardiogenic shock.
Radix et Rhizoma Rhei (stir-fried with wine):Hardship, cold in nature.Returns spleen, stomach, large intestine, liver, pericardium channel.Have heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, Effect of eliminating blood stasis and inducing menstruation.For the constipation that stagnates;Hygropyretic dysentery, jaundice, stranguria;Blood-head tells nosebleed, conjunctival congestion pharyngeal swelling;Pathopyretic ulcer;The stasis of blood Blood disorder.
Semen Arecae:Bitter, pungent, warm in nature.Return stomach, large intestine channel.There is parasite killing, removing food stagnancy, circulation of qi promoting, diuretic, preventing the attack (or recurrence) of malaria.For many Plant intestinal parasitical diseases;Stagnation of QI due to dyspepsia, weight after rush down dysentery;Edema, tinea pedis swell and ache;Malaria.
The Radix Aucklandiae:Pungent, bitter, warm in nature.Returns spleen, stomach, large intestine, gallbladder, tri-jiao channel.There is promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.With Demonstrate,prove in stagnation of QI in spleen and stomach;Dysentery tenesmus;Stomachache hypochondriac pain, jaundice, hernia pain;The thoracic obstruction of qi depression to blood stasis;Dyspepsia.
The Radix Pulsatillae:Hardship, cold in nature.Return stomach, large intestine channel.There is heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.For sore and toxic; Pudendal pruritus leukorrhagia;Tropical dysentery;Heat in blood bleeding and pyrexial malaria fever and irritability.
Radix Glycyrrhizae:Sweet, mild-natured.GUIXIN, lung, spleen, stomach.Have invigorating the spleen and replenishing QI, expelling phlegm for arresting cough, relieving spasm to stop pain, heat-clearing and toxic substances removing, Effect of coordinating the actions of various ingredients in a prescription.For deficiency of heart-QI, irregularly intermittent and regularly intermittent pulse, severe palpitation;Syndrome of deficiency of spleen qi;Cough with asthma;Gastral cavity abdomen, four limbs contraction;Heat Skin infection infectionss, laryngopharynx swelling and pain and medicine, alimentary toxicosis;Mediation property of medicine.
The Chinese medicine composition of the present invention analyzes humidity hysteresis and insufficiency of the spleen reciprocal causation according to theory of Chinese medical science, is that colitis cause and have loose bowels The key factor of formation.Insufficiency of the spleen with the passing of time must damage kidney yang, humidity hysteresis is not changed, unavoidable heat, if now alone warming therapy, help humidogene heat, disease Must not remove, if alone therapy for clearing away heat, damaging the spleen and stomach damages sun, also difficult recovery from illness, Zhi Dangwen is developed simultaneously clearly, Wen Yun does not forget Qinghua, Qinghua again must logical drop.Therefore Fang Zhongyong Radix Ginseng Rubra " strongly invigorating primordial QI, adjust Rong Yangwei ", with being monarch drug with invigorating the spleen and benefiting QI.Insufficiency of the spleen with the passing of time kidney yang is also damaged, Radix Aconiti Lateralis Preparata, Xin Gan Big heat, work(can warming the kidney to activate YANG, mend the warm soil of fire,《Book on Chinese herbal medicine is played》" which is removed internal organs heavy cold, is subsidized YANG QI deficiency with having three load Two, the non-Radix Aconiti Lateralis Preparata of warm taste three ... can not mend the yang deficiency of lower Jiao ";Rhizoma Zingiberiss are hot, and warming middle-JIAO is supporing yang, with Radix Aconiti Lateralis Preparata mutual reinforcement between are With, warming and recuperating the spleen and kidney, dispelling cold and removing dampness is ministerial drug altogether.The Radix Aucklandiae, Semen Arecae regulating qi-flowing for activating stagnancy;Radix Et Rhizoma Rhei bitter cold, processed with wine can cathartic purgation work(, deposit The property of its logical drop, because of the pungent perfume (or spice) of its abnormal smells from the patient, again can promoting the circulation of QI to relieve pain,《Records of Tradition Chinese and Western Medicine in Combination》Carry:" its gas is fragrant, thus simultaneous enter edema caused by disorder of QI, few The stagnation of QI can also be recuperated under medical treatment with it to make to ache ";Radix Pulsatillae clearing up internal heat by using drugs of bitter in taste and cold in nature, removing pathogenic heat from blood and toxic substance from the body, are apt to control the damp and hot disease of gastrointestinal, and this is assistant altogether Medicine, treating incontinent symptoms (pseudomorph) by dredging method.In making with the sweet mitigation of Radix Glycyrrhizae, coordinating the actions of various ingredients in a prescription.
2 react it is contemplated that blocking colitis, by " Wen Qing develops simultaneously, and Wen Yun does not forget Qinghua, and Qinghua is dropped when palpus is logical " Therapeutic Principle, spleen kidney preferably mends, damp and hot preferably clear, damp and hot in intestinal, giving treatment in accordance with the tendency of pathological change, must treating incontinent symptoms (pseudomorph) by dredging method, asthenia of both the spleen and kidney must kidney reinforcing medicine powder Cold, spleen invigorating dehumidifying, the Chinese medicine composition of proposition treatment colitis, all medicine phases 5, Wen Qing develops simultaneously, and cold and heat mutually help, and mends and does not help heat, clearly Impairment of YANG, the clinic that uses, do not produce effects rather good, and its effect is better than existing medicine, easy, effectively, have no toxic side effect, without drug dependence Property, the clinical treatment to colitis is significant.
Specific embodiment
With reference to embodiments the present invention is described in further details.
Embodiment 1:
Radix Aconiti Lateralis Preparata 9g, Rhizoma Zingiberiss 9g, Radix Ginseng Rubra 10g, Radix et Rhizoma Rhei (stir-fried with wine) 9g, Semen Arecae 12g, Radix Aucklandiae 15g, Radix Pulsatillae 12g and Radix Glycyrrhizae 9g.This enforcement Example is applied to serious symptom.
Embodiment 2:
Radix Aconiti Lateralis Preparata 3g, Rhizoma Zingiberiss 3g, Radix Ginseng Rubra 5g, Radix et Rhizoma Rhei (stir-fried with wine) 3g, Semen Arecae 9g, Radix Aucklandiae 9g, Radix Pulsatillae 6g and Radix Glycyrrhizae 3g.The present embodiment is fitted For mild.
Embodiment 3:
Radix Aconiti Lateralis Preparata 6g, Rhizoma Zingiberiss 6g, Radix Ginseng Rubra 5g, Radix et Rhizoma Rhei (stir-fried with wine) 6g, Semen Arecae 9g, Radix Aucklandiae 10g, Radix Pulsatillae 9g and Radix Glycyrrhizae 6g.The present embodiment For most preferred embodiment.
Above-described embodiment makes water decoction, pill(Including the watered pill, honeyed pill, dragee, soft gelatin capsule, enteric coated pill or drop pill), tea Agent, oral liquid, tablet, capsule, granule, unguentum or powder preparation formulation.
Instructions of taking:Daily 1 dose, divide 2 times and take, each 200ml.
Clinical trial example:
First, ordinary circumstance:
During selecting the August of 2016 June in 2015, the complete colitis disease 56 of applicant's Follow-up Data is all sick The enteral mirror of example is made a definite diagnosis.Wherein male 27, female 29, age 22-65 year;All patient's courses of disease are all higher than 1 month.Include patient Clinical manifestation is diarrhoea, stomachache, mucus bloody purulent stool.Colon mirror:Colorectal mucosa is congested, and rotten to the corn, pathological changes intestinal segment is with away from anus 60 Based on below centimetre.
2nd, curative effect determinate standard:
Effectively:Clinical symptoms disappear substantially, colonoscopy mucosa mild inflammation;
Temporarily cure:Clinical symptom disappearance, colonoscope check mucosa are substantially normal, are discontinued 6 months without recurrence;
Invalid:It is not improved through treating clinical symptoms and colonoscopy.
3rd, Therapeutic Method:
All patients give the water decoction of Chinese medicine composition of the present invention, daily 1 dose, divide 2 times and take, each 200ml, and the course for the treatment of is 4 weeks, follow-up half a year.
4th, result statistics:
After Chinese medicine composition of the present invention is to 56 colitis disease's treatments, clinical effective 21, temporarily cure 30, invalid 5, Total effective rate is 91.07%, and curative effect is obvious.
5th, conclusion:
Chinese medicine composition of the present invention can substantially mitigate colitis change, improve its clinical symptoms.
6th, model case:
Thunder, man, 26 years old, patient's recurrent diarrhea more than 3 years was once looked into intestinal mirror and was diagnosed as colitis, through in, doctor trained in Western medicine multi-treatment not More, existing disease stomachache is intended to just, and just matter is dilute half congealed, when have and do not digest food debriss, gently then day row two, three times, seven, eight times during weight, edible oil Greasy, increase, usually poor appetite lack of appetite, lean body mass, the micro- Huang of light red tongue, greasy fur, deep-thready pulse and cunning.It is diagnosed as having loose bowels, dialectical category is insufficiency of the spleen Damp and hot, 7 doses of the Chinese medicine composition of the present invention is given, is decocted in water for oral dose, daily 1 dose, divided 2 times and take, each 200ml defecates after medication Number of times is significantly reduced, and stomachache mitigates, and after pausing to add and subtract with front, more than the conditioning moon, all diseases are all lost.Phone is visited and is learnt, so far 1 year, diarrhoea was not shown effect.

Claims (3)

1. a kind of Chinese medicine composition for treating colitis, it is characterised in that:It is made up of the raw material of following weight:System is attached Piece 3-9 parts, Rhizoma Zingiberiss 3-9 parts, Radix Ginseng Rubra 5-10 parts, Radix et Rhizoma Rhei (stir-fried with wine) 3-9 parts, Semen Arecae 9-12 parts, Radix Aucklandiae 9-15 parts, Radix Pulsatillae 6-12 parts and Radix Glycyrrhizae 3-9 parts.
2. the Chinese medicine composition of colitis is treated according to claim 1, it is characterised in that:The weight portion of each raw material is matched somebody with somebody Than for:6 parts of 6 parts of Radix Aconiti Lateralis Preparata, 6 parts of Rhizoma Zingiberiss, 5 parts of Radix Ginseng Rubra, 6 parts of Radix et Rhizoma Rhei (stir-fried with wine), 9 parts of Semen Arecae, 10 parts of the Radix Aucklandiae, 9 parts of the Radix Pulsatillae and Radix Glycyrrhizae.
3. according to claim 1 or claim 2 treatment colitis Chinese medicine composition, it is characterised in that:It is made from it water decoction, ball Agent, medicinal tea, oral liquid, tablet, capsule, granule, unguentum or powder preparation formulation.
CN201610934562.2A 2016-11-01 2016-11-01 A kind of Chinese medicine composition for treating colitis Pending CN106492151A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107412655A (en) * 2017-03-28 2017-12-01 广西南岜仔科技有限公司 A kind of Chinese medicine preparation for treating damp-heat type chronic colitis and preparation method thereof
CN108042780A (en) * 2018-01-04 2018-05-18 薛晓春 A kind of Chinese medicine preparation for being used to treat colitis
JP2023003756A (en) * 2021-06-24 2023-01-17 広東省中医院 Herbal composition for improving gastrointestinal nutrient absorption, method for manufacturing the same and use thereof

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CN1449780A (en) * 2002-04-08 2003-10-22 胡庆武 Medicine for treating colitis and preparation process thereof
CN1520860A (en) * 2003-01-28 2004-08-18 山东中医药大学 Pharmaceutical composition for colitis
CN1559471A (en) * 2004-03-01 2005-01-05 肖振球 Chinese medicine/preparation

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CN1520860A (en) * 2003-01-28 2004-08-18 山东中医药大学 Pharmaceutical composition for colitis
CN1205981C (en) * 2003-01-28 2005-06-15 山东中医药大学 Pharmaceutical composition for colitis
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107412655A (en) * 2017-03-28 2017-12-01 广西南岜仔科技有限公司 A kind of Chinese medicine preparation for treating damp-heat type chronic colitis and preparation method thereof
CN108042780A (en) * 2018-01-04 2018-05-18 薛晓春 A kind of Chinese medicine preparation for being used to treat colitis
JP2023003756A (en) * 2021-06-24 2023-01-17 広東省中医院 Herbal composition for improving gastrointestinal nutrient absorption, method for manufacturing the same and use thereof
JP7394811B2 (en) 2021-06-24 2023-12-08 広東省中医院 Chinese herbal medicine composition for improving nutrient absorption in the gastrointestinal tract, its production method and use

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Application publication date: 20170315