CN106482418B - Gas/liquid nitrogen refrigerating system for freeze dryer - Google Patents

Gas/liquid nitrogen refrigerating system for freeze dryer Download PDF

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CN106482418B
CN106482418B CN201510538608.4A CN201510538608A CN106482418B CN 106482418 B CN106482418 B CN 106482418B CN 201510538608 A CN201510538608 A CN 201510538608A CN 106482418 B CN106482418 B CN 106482418B
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gas
liquid nitrogen
pipeline
heat
heat exchange
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CN106482418A (en
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谭亮
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Truking Technology Ltd
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Truking Technology Ltd
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Abstract

The invention discloses a gas/liquid nitrogen refrigerating system for a freeze dryer, which comprises a heat exchange device, a gas/liquid nitrogen mixing device, a liquid inlet pipeline, a gas inlet pipeline, a heat exchange pipeline and a heat preservation device, wherein the heat exchange device and the gas/liquid nitrogen mixing device are arranged in an inner cavity of the heat preservation device, the heat exchange device and the gas/liquid nitrogen mixing device are connected with equipment outside the heat preservation device through the liquid inlet pipeline and the heat exchange pipeline, and the gas inlet pipeline is communicated with the inner cavity of the heat preservation device. The system has the advantages of low operation cost, low energy loss and high utilization rate of liquid nitrogen.

Description

Gas/liquid nitrogen refrigerating system for freeze dryer
Technical Field
The invention mainly relates to the field of food and medicine packaging machinery, in particular to a gas/liquid nitrogen refrigerating system for a freeze dryer.
Background
The freeze dryer is a device for drying by utilizing the sublimation principle, and a refrigeration system is a core device of the freeze dryer. Freeze-drying machines adopted by pharmaceutical enterprises at present are all mechanical refrigeration systems: the refrigerant is compressed by a compressor in a closed system, is converted into high-pressure liquid under the action of a condensing heat exchanger, forms a mist shape through a throttling device, absorbs heat through evaporation of an evaporator, and exchanges heat in a continuous circulation process. The refrigeration system of the freeze dryer generally needs to adopt a high-cost double-stage compressor to form the refrigeration system because the refrigeration system requires low temperature and long operation time. The existing refrigeration mode has low energy efficiency and high operation cost due to the limitation of the compression ratio of the compressor and the loss of cold and heat in the circulation process.
Disclosure of Invention
The invention aims to solve the technical problem of overcoming the defects of the prior art and provides the gas/liquid nitrogen refrigerating system for the freeze dryer, which has low operation cost, small energy loss and high utilization rate of liquid nitrogen.
In order to solve the technical problems, the invention adopts the following technical scheme:
the gas/liquid nitrogen refrigerating system for the freeze dryer comprises a heat exchange device, a gas/liquid nitrogen mixing device, a liquid inlet pipeline, a gas inlet pipeline, a heat exchange pipeline and a heat preservation device, wherein the heat exchange device and the gas/liquid nitrogen mixing device are arranged in an inner cavity of the heat preservation device, the heat exchange device and the gas/liquid nitrogen mixing device are connected with equipment outside the heat preservation device through the liquid inlet pipeline and the heat exchange pipeline, and the gas inlet pipeline is communicated with the inner cavity of the heat preservation device.
As a further improvement of the above technical solution:
the heat exchange device comprises a first heat exchanger and a second heat exchanger, the gas/liquid nitrogen mixing device is arranged between the first heat exchanger and the second heat exchanger, the liquid inlet pipeline is connected between the gas/liquid nitrogen mixing device and the first heat exchanger, and the heat exchange pipeline is connected between the gas/liquid nitrogen mixing device and the second heat exchanger.
The gas/liquid nitrogen mixing device further comprises a precooling pipeline, one end of the precooling pipeline is connected to the heat exchange pipeline between the gas/liquid nitrogen mixing device and the second heat exchanger, and the other end of the precooling pipeline is connected to the liquid inlet pipeline between the first heat exchanger and the box body.
And gas return pipelines are connected between the second heat exchanger and the first heat exchanger and between the first heat exchanger and the gas/liquid nitrogen mixing device.
The box body is communicated with a pressure control pipeline extending to the outside, and a safety valve is arranged on the pressure control pipeline.
The liquid inlet pipeline is provided with a first adjusting valve, and the precooling pipeline is provided with a second adjusting valve.
And a temperature monitoring element and a third regulating valve are arranged on the heat exchange pipeline.
And the heat exchange pipeline is provided with a pressure monitoring element, and the liquid inlet pipeline and the gas inlet pipeline are both provided with pressure regulating valves.
The heat preservation device comprises a box body and a heat insulation layer, the heat insulation layer is coated on the periphery of the box body, the heat exchange device and the gas/liquid nitrogen mixing device are arranged in an inner cavity of the box body, and the air inlet pipeline is communicated with the inner cavity of the box body.
The inlet ends of the liquid inlet pipeline and the gas inlet pipeline are connected with a gas/liquid nitrogen supplement source, and the heat exchange pipeline is connected with the freeze dryer.
Compared with the prior art, the invention has the advantages that:
according to the gas/liquid nitrogen refrigerating system for the freeze dryer, the heat exchange device and the gas/liquid nitrogen mixing device are arranged in the inner cavity of the heat preservation device, the heat exchange device and the gas/liquid nitrogen mixing device are connected with equipment outside the heat preservation device through the liquid inlet pipeline and the heat exchange pipeline, and the gas inlet pipeline is communicated with the inner cavity of the heat preservation device. The system utilizes the gas/liquid nitrogen mixing device to mix and atomize the liquid nitrogen entering from the liquid inlet pipeline and the nitrogen generated after the heat exchange of the liquid nitrogen, and then realizes the heat exchange with the freeze dryer through the heat exchange device and the heat exchange pipeline, thereby achieving the purpose of refrigeration and having low operation cost; and the heat exchange device and the gas/liquid nitrogen mixing device are arranged in the inner cavity of the heat preservation device, dry nitrogen introduced through the air inlet pipeline is used for preserving heat, and the frosting and freezing of the heat exchange device and the gas/liquid nitrogen mixing device in the heat preservation device can be prevented, so that a frost prevention technology is formed, the energy loss is greatly reduced, the energy is fully utilized, and the utilization rate of liquid nitrogen is improved.
Drawings
Fig. 1 is a schematic view showing the structure of an air/liquid nitrogen refrigerating system for a freeze dryer according to the present invention.
Fig. 2 is a diagram showing the state of use of the air/liquid nitrogen refrigerating system for the freeze dryer of the present invention.
The reference numerals in the figures denote:
1. a heat exchange device; 11. a first heat exchanger; 12. a second heat exchanger; 2. a gas/liquid nitrogen mixing device; 3. a liquid inlet pipeline; 31. a first regulating valve; 4. an air intake line; 5. a heat exchange line; 51. a temperature monitoring element; 52. a third regulating valve; 53. a pressure monitoring element; 6. a heat preservation device; 61. a box body; 62. a thermal insulation layer; 7. a pre-cooling pipeline; 71. a second regulating valve; 8. a gas return line; 9. a pressure control pipeline; 91. a safety valve; 10. a pressure regulating valve; 13. a gas/liquid nitrogen make-up source; 14. a freeze dryer.
Detailed Description
The invention will be described in further detail below with reference to the drawings and specific examples.
As shown in fig. 1, the system of the present invention for refrigerating gas/liquid nitrogen for a freeze dryer comprises a heat exchange device 1, a gas/liquid nitrogen mixing device 2, a liquid inlet pipeline 3, a gas inlet pipeline 4, a heat exchange pipeline 5 and a heat preservation device 6, wherein the heat exchange device 1 and the gas/liquid nitrogen mixing device 2 are installed in an inner cavity of the heat preservation device 6, the heat exchange device 1 and the gas/liquid nitrogen mixing device 2 are connected with equipment outside the heat preservation device 6 through the liquid inlet pipeline 3 and the heat exchange pipeline 5, and the gas inlet pipeline 4 is communicated with the inner cavity of the heat preservation device 6. Compared with the traditional compressor compression refrigeration, the system utilizes the gas/liquid nitrogen mixing device 2 to mix and atomize the liquid nitrogen entering from the liquid inlet pipeline 3 and the nitrogen generated after the heat exchange of the liquid nitrogen, and then realizes the heat exchange with the freeze dryer through the heat exchange device 1 and the heat exchange pipeline 5, thereby achieving the purpose of refrigeration and having low operation cost; moreover, the heat exchange device 1 and the gas/liquid nitrogen mixing device 2 are arranged in the inner cavity of the heat preservation device 6, dry nitrogen introduced through the air inlet pipeline 4 is used for preserving heat, frosting and freezing of the heat exchange device 1 and the gas/liquid nitrogen mixing device 2 in the heat preservation device 6 can be prevented, namely, a frost prevention technology is formed, energy loss is greatly reduced, energy is fully utilized, and the utilization rate of liquid nitrogen is improved.
In this embodiment, the heat exchange device 1 includes a first heat exchanger 11 and a second heat exchanger 12, the gas/liquid nitrogen mixing device 2 is disposed between the first heat exchanger 11 and the second heat exchanger 12, the liquid inlet pipeline 3 is connected between the gas/liquid nitrogen mixing device 2 and the first heat exchanger 11, and the heat exchange pipeline 5 is connected between the gas/liquid nitrogen mixing device 2 and the second heat exchanger 12. In this structure, liquid nitrogen and nitrogen gas that get into from feed liquor pipeline 3 and return gas pipeline 8 tentatively exchange heat in first heat exchanger 11, then go into gas/liquid nitrogen mixing arrangement 2 (mixing ejector) and mix the atomizing, reentrant second heat exchanger 12 and carry out the heat transfer through heat transfer pipeline 5 and freeze dryer, in order to reach cryogenic purpose, its simple structure, through multistage heat transfer, the utilization ratio of liquid nitrogen has been improved greatly, the utilization ratio of its liquid nitrogen is 30% higher than conventional liquid nitrogen heat transfer device.
In this embodiment, the system further includes a pre-cooling pipeline 7, one end of the pre-cooling pipeline 7 is connected to the heat exchange pipeline 5 between the gas/liquid nitrogen mixing device 2 and the second heat exchanger 12, and the other end of the pre-cooling pipeline 7 is connected to the liquid inlet pipeline 3 between the first heat exchanger 11 and the box body 61. In this structure, after freeze dryer automatic cycle starts, and when sending the order of starting refrigerating system, the liquid nitrogen gets into precooling pipeline 7 and evaporates through second heat exchanger 12 by liquid inlet pipe way 3 earlier, when the exhaust gas temperature of second heat exchanger 12 reached and the temperature of freeze dryer interface differs within 10 degrees, then carry out foretell multistage heat transfer refrigeration again, set up like this, can guarantee that the export temperature of second heat exchanger 12 differs within 10 degrees with the temperature of freeze dryer interface, make the liquid nitrogen can gasify completely, the utilization ratio of liquid nitrogen has been improved, reduce the use amount of liquid nitrogen, make freeze-drying cost reduce.
In this embodiment, the return gas line 8 is connected between the second heat exchanger 12 and the first heat exchanger 11, and between the first heat exchanger 11 and the gas/liquid nitrogen mixing device 2. In this structure, partly through the 5 discharges of heat transfer pipeline of nitrogen gas behind second heat exchanger 12, another part then can flow back to and carry out the heat transfer in first heat exchanger 11 through return air pipeline 8, nitrogen gas after the heat transfer will enter into gas/liquid nitrogen mixing arrangement 2, mix with the liquid nitrogen, reentrant second heat exchanger 12 exhaust system again after absorbing the heat, this return air pipeline 8 set up the utilization ratio that has improved nitrogen gas, the freeze-drying cost has further been reduced, and use environmental protection more.
In this embodiment, the box body 61 is communicated with a pressure control pipeline 9 extending to the outside, and the pressure control pipeline 9 is provided with a safety valve 91. In this structure, can control the pressure of box body 61 inner chamber through accuse pressure pipeline 9 and relief valve 91, ensure to fill nitrogen volume and control at a reasonable within range all the time, guaranteed the security of the stability and the use of box body 61 inner chamber.
In this embodiment, the first adjusting valve 31 is disposed on the liquid inlet pipeline 3, and the second adjusting valve 71 is disposed on the pre-cooling pipeline 7. In this structure, after the freeze dryer automatic cycle starts, and when sending the order of starting refrigerating system, first governing valve 31 is closed, second governing valve 71 is opened, liquid nitrogen gets into precooling pipeline 7 and evaporates through second heat exchanger 12 by liquid inlet pipeline 3 earlier, when the exhaust gas temperature of second heat exchanger 12 reaches and the temperature difference of freeze dryer interface is within 10 degrees, second governing valve 71 is closed, first governing valve 31 is opened, liquid nitrogen carries out multistage heat transfer refrigeration through first heat exchanger 11, gas/liquid nitrogen mixing arrangement 2 and second heat exchanger 12 by feed liquor pipeline 3 in proper order, its simple structure, convenient to use.
In this embodiment, the heat exchange pipeline 5 is provided with a temperature monitoring element 51 and a third regulating valve 52. In this structure, the outlet temperature and pressure of the nitrogen gas are kept within a reasonable range by monitoring of the temperature monitoring element 51 and the opening degree of the third regulating valve 52, and the use is more environment-friendly.
In this embodiment, the heat exchange pipeline 5 is provided with a pressure monitoring element 53, and the liquid inlet pipeline 3 and the gas inlet pipeline 4 are both provided with a pressure regulating valve 10. In this structure, the pressure in the inner cavity of the box body 61 can be further controlled by controlling the monitoring pressure regulating valve 10 of the pressure monitoring element 53, and the stability and the use safety of the inner cavity of the box body 61 are further improved.
In this embodiment, the heat preservation device 6 includes a box 61 and a heat insulation layer 62, the heat insulation layer 62 is wrapped around the box 61, the heat exchange device 1 and the gas/liquid nitrogen mixing device 2 are installed in the inner cavity of the box 61, and the air inlet pipeline 4 is communicated with the inner cavity of the box 61. In this structure, insulating layer 62 keeps apart box body 61 with the external world well to guarantee the cryogenic continuation of gas/liquid nitrogen of box body 61 inner chamber, prevented the loss of cold volume, ensured the full utilization of energy.
In this embodiment, the inlet ends of the liquid inlet pipeline 3 and the gas inlet pipeline 4 are connected to a gas/liquid nitrogen supplement source 13, and the heat exchange pipeline 5 is connected to a freeze dryer 14. In this structure, gas/liquid nitrogen is constantly supplyed gas/liquid nitrogen in the heat preservation device 6 through liquid inlet pipeline 3 and air inlet pipeline 4 to gas/liquid nitrogen supply source 13, and heat exchange is realized with freeze dryer 14 butt joint to heat transfer pipeline 5, has formed stable freeze dryer refrigerating system, and in addition, its area is little for the factory building utilization ratio of pharmaceutical factory improves, easy to maintain and maintenance.
Although the present invention has been described with reference to the preferred embodiments, it is not intended to be limited thereto. Those skilled in the art can make numerous possible variations and modifications to the present invention, or modify equivalent embodiments to equivalent variations, without departing from the scope of the invention, using the teachings disclosed above. Therefore, any simple modification, equivalent change and modification made to the above embodiments according to the technical spirit of the present invention should fall within the protection scope of the technical scheme of the present invention, unless the technical spirit of the present invention departs from the content of the technical scheme of the present invention.

Claims (8)

1. The utility model provides a gas/liquid nitrogen refrigerating system for freeze dryer which characterized in that: the heat-preservation device comprises a heat exchange device (1), a gas/liquid nitrogen mixing device (2), a liquid inlet pipeline (3), an air inlet pipeline (4), a heat exchange pipeline (5) and a heat preservation device (6), wherein the heat exchange device (1) and the gas/liquid nitrogen mixing device (2) are arranged in an inner cavity of the heat preservation device (6), the heat exchange device (1) and the gas/liquid nitrogen mixing device (2) are connected with equipment outside the heat preservation device (6) through the liquid inlet pipeline (3) and the heat exchange pipeline (5), the air inlet pipeline (4) is communicated with the inner cavity of the heat preservation device (6), the heat exchange device (1) comprises a first heat exchanger (11) and a second heat exchanger (12), the gas/liquid nitrogen mixing device (2) is arranged between the first heat exchanger (11) and the second heat exchanger (12), the liquid inlet pipeline (3) is connected between the gas/liquid nitrogen mixing device (2) and the first heat exchanger (11), the gas/liquid nitrogen mixing device (2) is connected with the second heat exchanger (12) through the heat exchange pipeline (5), the second heat exchanger (12) is connected with the first heat exchanger (11), the liquid nitrogen mixing device (11) and the first heat exchanger (8), and the heat exchanger (8) are connected with the heat exchange pipeline (8), and the heat exchange pipeline (8) And (3) exchanging heat, then entering a gas/liquid nitrogen mixing device (2) for mixing and atomizing, then entering a second heat exchanger (12) and exchanging heat with the freeze dryer through a heat exchange pipeline (5).
2. The gas/liquid nitrogen refrigerating system for a freeze dryer according to claim 1, wherein: the heat exchanger is characterized by further comprising a precooling pipeline (7), wherein one end of the precooling pipeline (7) is connected to the heat exchange pipeline (5) between the gas/liquid nitrogen mixing device (2) and the second heat exchanger (12), and the other end of the precooling pipeline (7) is connected to the liquid inlet pipeline (3) between the first heat exchanger (11) and the box body (61).
3. The gas/liquid nitrogen refrigerating system for a freeze dryer according to claim 2, wherein: the box body (61) is communicated with a pressure control pipeline (9) extending to the outside, and a safety valve (91) is arranged on the pressure control pipeline (9).
4. The gas/liquid nitrogen refrigeration system for a freeze dryer according to any one of claims 2 to 3, wherein: and a first regulating valve (31) is arranged on the liquid inlet pipeline (3), and a second regulating valve (71) is arranged on the precooling pipeline (7).
5. The gas/liquid nitrogen refrigeration system for a freeze dryer according to claim 4, wherein: and a temperature monitoring element (51) and a third regulating valve (52) are arranged on the heat exchange pipeline (5).
6. The gas/liquid nitrogen refrigeration system for a freeze dryer according to any one of claims 1 to 3, wherein: and a pressure monitoring element (53) is arranged on the heat exchange pipeline (5), and pressure regulating valves (10) are arranged on the liquid inlet pipeline (3) and the air inlet pipeline (4).
7. The gas/liquid nitrogen refrigeration system for a freeze dryer according to any one of claims 1 to 3, wherein: the heat preservation device (6) comprises a box body (61) and a heat insulation layer (62), wherein the heat insulation layer (62) is coated on the periphery of the box body (61), the heat exchange device (1) and the gas/liquid nitrogen mixing device (2) are arranged in an inner cavity of the box body (61), and the gas inlet pipeline (4) is communicated with the inner cavity of the box body (61).
8. The gas/liquid nitrogen refrigeration system for lyophilizer according to any one of claims 1 to 3, characterized in that: the inlet ends of the liquid inlet pipeline (3) and the gas inlet pipeline (4) are connected with a gas/liquid nitrogen supplement source (13), and the heat exchange pipeline (5) is connected with the freeze dryer (14).
CN201510538608.4A 2015-08-28 2015-08-28 Gas/liquid nitrogen refrigerating system for freeze dryer Active CN106482418B (en)

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CN107345730B (en) * 2017-07-21 2022-09-20 中国科学院理化技术研究所 Cryogenic treatment device

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