CN106474414A - A kind of Chinese herbal granules of invigorating the spleen Tongluo Jiedu - Google Patents

A kind of Chinese herbal granules of invigorating the spleen Tongluo Jiedu Download PDF

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CN106474414A
CN106474414A CN201611012061.5A CN201611012061A CN106474414A CN 106474414 A CN106474414 A CN 106474414A CN 201611012061 A CN201611012061 A CN 201611012061A CN 106474414 A CN106474414 A CN 106474414A
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chinese herbal
radix
herbal granules
root
chinese
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谢海青
杨安平
冯志刚
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Foshan University
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Foshan University
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Priority to CN201611012061.5A priority Critical patent/CN106474414A/en
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Priority to PCT/CN2017/109618 priority patent/WO2018090848A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K35/63—Arthropods
    • A61K35/648—Myriapods, e.g. centipedes or millipedes
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/88—Liliopsida (monocotyledons)
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Abstract

The invention discloses a kind of Chinese herbal granules of invigorating the spleen Tongluo Jiedu, filling a prescription is：20 40g of the Radix Astragali, 10 25g of Radix Codonopsis, 10 20g of the bighead atractylodes rhizome, 1 10g of licorice, drought 5 15g of the tuber of pinellia, 5 15g of dried orange peel, 5 15g of fructus amomi, 7 18g of rhizoma cyperi processed, 20 40g of Polygonum multiflower knotweed, centipede 13,10 20g of earthworm, 10 20g of the root of Chinese clematis, 5 15g of profound Hu, 20 40g of the red sage root, 5 15g of radix bupleuri, 20 40g of Radix Isatidis, 20 40g of adlay, 5 15g of indigo naturalis；The Chinese herbal granules are obtained by following methods：Each raw material is weighed by formula, make bead dosage form.Medicine composition of the present invention is simple, and treatment method is simple, instant effect, can be while effectively treatment herpes zoster and its post herpetic neuralgia, bedsore and ulcer on the shank, mitigate patient's pain significantly.

Description

A kind of Chinese herbal granules of invigorating the spleen Tongluo Jiedu
Technical field
The present invention relates to field of medicaments, more particularly to a kind of Chinese herbal granules of invigorating the spleen Tongluo Jiedu.
Background technology
Herpes zoster is the acute infection dermatoses caused by varicella virus.After some patientss are infected Become carrier and symptom does not occur.As virus has neurotropism, root after the spinal nerve of can hiding for a long time after infection In ganglionic neuron, when lower for the resistance or tired, infection, flu, virus can regrow breeding, and fine along nerve Dimension moves to skin, makes the nerve that is invaded and skin produce strong inflammation.Fash typically has Unilateral and divides by nerve segment The feature of cloth, is made up of the bleb of cluster, and with pain.Patient is often difficult in treatment stand the side reaction of doctor trained in Western medicine. And, suffer from this sick people during diagnosis and treatment, while some is found with other diseases, such as malignant tumour or glycosuria Disease, this can allow the treatment of this disease increasingly difficult.
Bedsore also known as pressure ulcer, pressure sore, be due to local organization pressurized for a long time, occur continuous ischemia, anoxic, nutrition Bad and cause tissue fester necrosis.Skin bedsore is the problem of a universality, mostly long-term bed in rehabilitation, nursing The patient not risen, is caused due to weight and the friction of body, with limitation superficial skin injury, based on the open sore part does not recover for a long time Chronic sore class disease to be showed.According to relevant document report, there are about 60,000 people every year and die from pressure sore concomitant symptoms.Existing treatment cotton-padded mattress The method of sore mainly includes：（1）Sterile package hypodesmus：Carry out disinfection cleaning to the sore face of patient, is uniformly covered using ointment after cleaning The lid surface of a wound, is wrapped up with aseptic dressing, promotes the quick hyperplasia of patient wound, so as to accelerate the healing of the surface of a wound.（2）Hyperbaric oxygentherapy Bedsore：The surface of a wound is covered with polybag, pure oxygen, the effect that sore face can be promoted in such a case to heal is sent into into bag.（3）Red Outside line irradiation treatment bedsore：By infrared radiation sore face 20 minutes, daily 3 to 4 times, sore face can be promoted quickly to scab. （4）Chinese Traditional Medicine is treated：The clear soak treatment bedsore of bedsore, daily soak 3 to 4 times, 30 minutes every time.Held back by hygroscopic Sore, promoting blood circulation and removing blood stasis, menstruation regulating dredging collateral, remove necrosis and promote granulation, quick, safety, comprehensively treat bedsore.
Ulcer on the shank refers to the chronic ulcer for occurring in shank bottom：Also known as leg opening poison, ecthyma, slow equivalent to the shank of doctor trained in Western medicine Property ulcer.Being secondary to evil arteries and veins this disease more（Varix of lower limb）With diseases such as erysipelas.Its clinical characters is to be mainly in shank lower 1/3 Outside in before intersection, ulcer occur before affected part chronic skin ecchymosis, coarse, though after festering, the open sore part does not recover for a long time or has received Mouthful, often easily recur because of local damage.Ulcer on the shank is many to be stood or heavy burden long journey because long, overworked, wasting QI-blood, the sinking of qi of middle-jiao, with Causing lower limb QI-blood circulation not smooth, or evil arteries and veins stagnation of QI-blood being formed in skin, failure of skin and muscle to be nourished, again because damaging（Bite by mosquitos, wet sore, Damage）, damp and hot heresy takes advantage of a weak point in opponent's defence and people, sends out as sore, and skin festers, do not recover for a long time.The method of existing treatment ulcer on the shank is mainly wrapped Include：（1）Traditional operates on method, is commonly called as " pulling out a tendon and skin ", and it is time-consuming to process lesion vesselses complexity, operates on that otch is many, wound weight, bitterly Bitter big, length of patient stay's length, recover slow, postoperative have scar, and unsightly, complication is many；（2）Minimally Invasive Surgery method：Main generation Table method such as microwave Endovascular Therapy art, by closing the big of pathology（Little）It is quiet that saphena, the category of varicose prop up vein, traffic Arteries and veins, reaching improves veins of lower extremity backflow, releases lower limb hemostasis, treats this sick purpose；While postoperative cooperation clearing heat and promoting diuresis, corruption of dispelling The oral medicinal herb of myogenic, external application, can comparatively fast promote skin ulcer to heal, obtain the effect of disease cured.
Content of the invention
The technical problem to be solved is, provides a kind of Chinese herbal granules of invigorating the spleen Tongluo Jiedu, medicine group Become simple, treatment method is simple, instant effect, can while effectively treatment herpes zoster and its post herpetic neuralgia, bedsore and ulcer on the shank, Mitigate significantly patient's pain.
For reaching above-mentioned technique effect, the invention provides a kind of Chinese herbal granules of invigorating the spleen Tongluo Jiedu, the Chinese medicine The formula of granule is：
Radix Astragali 20-40g, Radix Codonopsis 10-25g, bighead atractylodes rhizome 10-20g, licorice 1-10g, drought tuber of pinellia 5-15g, dried orange peel 5-15g, sand Benevolence 5-15g, rhizoma cyperi 7-18g processed, Polygonum multiflower knotweed 20-40g, centipede 1-3 bar, earthworm 10-20g, root of Chinese clematis 10-20g, profound Hu 5- 15g, red sage root 20-40g, radix bupleuri 5-15g, Radix Isatidis 20-40g, adlay 20-40g, indigo naturalis 5-15g；
The Chinese herbal granules are obtained by following methods：Each raw material is weighed by formula, crush and mix；Add water to submerge medicinal material Heating is decocted afterwards, the fried liquid of separation, after filtration, water decoction is evaporated, cold rear addition 1-2 times amount ethanol, is placed precipitation, is taken which Supernatant, sediment are cleaned with ethanol again, and washing lotion merges with filtrate, after decompression recycling ethanol, filtration, and filtrate low-temperature evaporation is to thick Paste, obtains medicinal extract；After medicinal extract and auxiliary materials and mixing, plus softwood made by wetting agent；Softwood is made bead dosage form with granulator, Pack.
Used as the improvement of such scheme, the formula of the Chinese herbal granules is：
Radix Astragali 25-35g, Radix Codonopsis 15-20g, bighead atractylodes rhizome 12-18g, licorice 3-8g, drought tuber of pinellia 7-12g, dried orange peel 8-12g, sand Benevolence 8-12g, rhizoma cyperi 10-15g processed, Polygonum multiflower knotweed 25-35g, centipede 2-3 bar, earthworm 12-18g, root of Chinese clematis 12-18g, profound Hu 7-12g, red sage root 25-35g, radix bupleuri 8-12g, Radix Isatidis 25-35g, adlay 25-35g, indigo naturalis 8-12g.
Used as the improvement of such scheme, the formula of the Chinese herbal granules is：
Radix Astragali 30g, Radix Codonopsis 18g, bighead atractylodes rhizome 15g, licorice 6g, drought tuber of pinellia 10g, dried orange peel 10g, fructus amomi 10g, rhizoma cyperi processed 12g, Polygonum multiflower knotweed 30g, centipede 2, earthworm 15g, root of Chinese clematis 15g, profound Hu 10g, red sage root 30g, radix bupleuri 10g, Radix Isatidis 30g, Adlay 30g, indigo naturalis 10g.
Used as the improvement of such scheme, described water decoction is evaporated to concentration proportion for 1：1.05.
Used as the improvement of such scheme, the auxiliary material is starch, dextrin and/or sucrose.
Used as the improvement of such scheme, the temperature of the low-temperature evaporation is 60-70 DEG C.
Used as the improvement of such scheme, the wetting agent is 75-85% ethanol.
As the improvement of such scheme, include the step of softwood is made bead dosage form with granulator：
Softwood is made wet grain with granulator, the water content of wet grain is 7-10%；
Wet grain is dried to bead dosage form by drying machine, the drying temperature of drying machine is 70-80 DEG C.
Implement the present invention to have the advantages that：
The main pathogenesis of herpes zoster are asthenia in origin and asthenia in superficiality, mixture of asthenia and sthenia, are embodied in insufficiency of the spleen blood stasis poison knot.Radix Codonopsis of the present invention, The bighead atractylodes rhizome, licorice, fructus amomi, rhizoma cyperi processed, adlay, dried orange peel, the non-irrigated tuber of pinellia add the Radix Astragali, Polygonum multiflower knotweed, it is intended to strengthening the spleen and replenishing qi and stomach, nourishing heart Calm the nerves；The removing toxic substances promoting blood circulation and removing obstruction in channels of centipede, earthworm, the root of Chinese clematis, profound Hu, the red sage root, radix bupleuri, Radix Isatidis, indigo naturalis relieves the pain.The present invention plays invigorating the spleen The effect of removing toxic substances promoting blood circulation and removing obstruction in channels, puts righting in the first place, otherwise, clearing heat and detoxicating simply, most easy damaged middle-jiao yang, function of the spleen and stomach and occur abdominal distention and pain, Vomiting, spiritlessness and sparing of words, the discomfort such as limbs fatigue, cause patient more painful and treatment cannot be adhered to.The present invention is only by above-mentioned medicine Thing constitutes, and constitutes simply, and medicament sources are enriched, cheap；Treatment method is simple, it is only necessary to for oral administration, mitigates patient and bears Load.And, patient only needs to take 1 dose of decoction of medicinal ingredients daily, takes and just substantially mitigates pain in 3 days or so, fullys recover from an illness by taking 7 days or so More, instant effect.Additionally, the present invention single pair of Patients with Herpes Zoster is not effective in cure, and, if Patients with Herpes Zoster is while also suffer from which When his disease, such as malignant tumour or diabetes, the present invention can also effectively treatment, and toxic and side effect is little, hence it is evident that mitigate patient's pain Bitter.
Further, single pair of Patients with Herpes Zoster is not effective in cure for the present invention, while can be controlled with effectively treatment bedsore and ulcer on the shank When bedsore and ulcer on the shank is treated, also take 1 dose of decoction of medicinal ingredients daily, take 2-3 days or so, the state of an illness is clearly better, take 5-7 days left sides Recovery from illness, instant effect by right, and toxic and side effect is little, hence it is evident that mitigate patient suffering.
Specific embodiment
For making the object, technical solutions and advantages of the present invention clearer, the present invention will be made below further detailed Description.
The invention provides a kind of Chinese herbal granules of invigorating the spleen Tongluo Jiedu, the formula of the Chinese herbal granules is：
Radix Astragali 20-40g, Radix Codonopsis 10-25g, bighead atractylodes rhizome 10-20g, licorice 1-10g, drought tuber of pinellia 5-15g, dried orange peel 5-15g, sand Benevolence 5-15g, rhizoma cyperi 7-18g processed, Polygonum multiflower knotweed 20-40g, centipede 1-3 bar, earthworm 10-20g, root of Chinese clematis 10-20g, profound Hu 5- 15g, red sage root 20-40g, radix bupleuri 5-15g, Radix Isatidis 20-40g, adlay 20-40g, indigo naturalis 5-15g.
The Chinese herbal granules are obtained by following methods：Each raw material is weighed by formula, crush and mix；Add water to submerge After medicinal material, heating is decocted, the fried liquid of separation, after filtration, water decoction is evaporated, cold rear addition 1-2 times amount ethanol, places precipitation, Its supernatant is taken, sediment is cleaned with ethanol again, and washing lotion is merged with filtrate, after decompression recycling ethanol, filter, filtrate low-temperature evaporation To paste, medicinal extract is obtained；After medicinal extract and auxiliary materials and mixing, plus softwood made by wetting agent；Softwood is made particle with granulator Formulation, packs.
The formula of the Chinese herbal granules is preferably：
Radix Astragali 25-35g, Radix Codonopsis 15-20g, bighead atractylodes rhizome 12-18g, licorice 3-8g, drought tuber of pinellia 7-12g, dried orange peel 8-12g, sand Benevolence 8-12g, rhizoma cyperi 10-15g processed, Polygonum multiflower knotweed 25-35g, centipede 2-3 bar, earthworm 12-18g, root of Chinese clematis 12-18g, profound Hu 7-12g, red sage root 25-35g, radix bupleuri 8-12g, Radix Isatidis 25-35g, adlay 25-35g, indigo naturalis 8-12g.
More preferably, the formula of the Chinese herbal granules is：
Radix Astragali 30g, Radix Codonopsis 18g, bighead atractylodes rhizome 15g, licorice 6g, drought tuber of pinellia 10g, dried orange peel 10g, fructus amomi 10g, rhizoma cyperi processed 12g, Polygonum multiflower knotweed 30g, centipede 2, earthworm 15g, root of Chinese clematis 15g, profound Hu 10g, red sage root 30g, radix bupleuri 10g, Radix Isatidis 30g, Adlay 30g, indigo naturalis 10g.
Wherein, the Radix Astragali, also known as continuous stilbene, which has enhancing body's immunity, liver protection, diuresis, anti-aging, resisting stress, step-down With wide antibacterial action.But table is real evil to be contained, and retention of dampness due to stagnation of QI, dyspepsia are stagnated, ulcer from the beginning of or the real example such as heat toxin Shang Sheng after bursting, And hyperactivity of yang due to yin deficiency person, clothes must be prohibited.
Radix Codonopsis, the effect of with tonifying middle-Jiao and Qi, strengthening spleen and tonifying lung, can with strengthen immunity, expansion of blood vessels, step-down, improve micro- Circulation, enhancing hematopoiesis function.In addition the leucocyte for chemotherapy radiotherapy being caused declines castering action.
The bighead atractylodes rhizome, with strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, antiabortive effect, for spleen eating less, abdominal distention diarrhea, phlegm and retained fluid Feel dizzy and heart palpitations, oedema, spontaneous perspiration, fetal irritability.《Medicine origin》Record：" dehumidifying benefit is dry, and middle beneficial gas, middle benefit gas, goes wet in taste, removes Stomach energy, strong taste, enter diet, antiabortive.”
Licorice, another name lantern, close sweet（Honey is sweet）, close grass, state is old, powder is careless, Herba Hedyotis cantonensis, sweet root, rod grass, medicinal part be root and Rhizome, plays the role of tonifying middle-Jiao and Qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, mediation property of medicine.
The non-irrigated tuber of pinellia, another name corbie eye, water is beautiful, literary, three steps jump, numb semen myristicae etc., stem tuber is used as medicine, can be eliminating dampness and eliminating phlegm, and drop is inverse Preventing or arresting vomiting, raw with the furuncle that disappears；Cure mainly coughing with a lot of sputum, n and V；Acute mastitis, acute-chronic purulent tympanitis are controlled in external application.
Dried orange peel, regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm, for abdominal fullness and distention, deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.
Fructus amomi, another name：Fructus Amomi, Changtai fructus（Fujian）, also known as cardamom, the taste stagnation of the circulation of vital energy is cured mainly, place food does not disappear, Stomachache ruffian is swollen, dysphagic vomiting, tremble with fear and rush down cold dysentery.
Rhizoma cyperi processed, taste is pungent, slight bitter, sweet, mild-natured, with dispersing stagnated hepatoqi, the effect of menstruction regulating and pain relieving.Irritability stasis is cured mainly, uncomfortable in chest Hypochondriac pain, stomach trouble, stomachache；And irregular menstruation, the illness such as dysmenorrhoea.
Polygonum multiflower knotweed, the effect of with mental-tranquilization, wind-dispelling, dredging collateral.For having a sleepless night, dreaminess, deficiency of blood bodily pain, numbness, Arthralgia due to wind-dampness, rubella itch.
Centipede, with wind-dispelling, calms the frightened, attacks poison, the effect of dissipating bind.Control apoplexy, frightened epilepsy, lockjaw, pertussis, scrofula, tuberculosis, Buildup block, sore swollen toxin, wind tinea, bald in vain, anal fistula, scald.
Earthworm, acts on clearing and activating the channels and collaterals, promoting blood circulation and removing blood stasis, prophylactic treatment cardiovascular and cerebrovascular disease.Cure mainly pyreticosis shy mad, children Infantile convulsion, cough and asthma, hot eyes of having a headache, abscess of throat, urinary obstruction, Fengshi Guanjie pain, hemiplegia, high fever frightened epilepsy, move wind and twitch, Lung heat productive cough is panted, and hot numbness section swells red pain.
The root of Chinese clematis, root and stem are used as medicine, the effect of stalk with wines used as antirheumatic, degrading the channel, the bone that disappears.
Profound Hu, also known as corydalis tuber, corydalis tuber, with promoting blood circulation to remove blood stasis, the effect of promoting qi circulation and relieving pain.
The red sage root, with promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness that clears away heart-fire, the effect of cool blood to disappear carbuncle.For chest impediment and cardialgia, gastral cavity abdomen Hypochondriac pain, lump in the abdomen lump in the abdomen are gathered, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhoea Amenorrhea, sore swell and ache curative.
Radix bupleuri, another name ground is smoked, mountain dish, mushroom are careless, faggot.In having and inducing sweat, soothing the liver rise sun the effect of.For cold, fever, Fevers and chills alternate, malaria, stagnation of QI due to depression of the liver, sternal rib pain, prolapse of the anus, the prolapse of uterus, irregular menstruation.
Radix Isatidis, another name：Indigo-blue, indigo root, manyflower glorybower root, with clearing heat and detoxicating, the effect of cool blood profit pharynx.It is usually used in temperature Poison during epidemic disease, pharyngalgia of generating heat, febrile virulent maculae, mumps, scarlet fever, major part pestilence, erysipelas, carbuncle swells.
Adlay, property slightly sweet flavor are slightly cold, and have inducing diuresis for removing edema, invigorating spleen to remove dampness, relaxing muscles and tendons except the effects such as numbness, clearing away heat and eliminating pus, are conventional Damp-clearing drug.
Indigo naturalis, the clearing heat and detoxicating, blood cooling and ecchymoses removing of tool, the effect such as purging intense heat arresting convulsion, contain for warm disease heat, macula, haematemesis, spitting of blood, Pharyngalgia aphtha, pediatric epilepsy scared, sore swells, erysipelas, snake bite and insect sting etc..
The main pathogenesis of herpes zoster are asthenia in origin and asthenia in superficiality, mixture of asthenia and sthenia, are embodied in insufficiency of the spleen blood stasis poison knot.Party of the present invention Ginseng, the bighead atractylodes rhizome, licorice, fructus amomi, rhizoma cyperi processed, adlay, dried orange peel, the non-irrigated tuber of pinellia add the Radix Astragali, Polygonum multiflower knotweed, it is intended to strengthening the spleen and replenishing qi and stomach, support Heart and tranquilizing mind；The removing toxic substances promoting blood circulation and removing obstruction in channels of centipede, earthworm, the root of Chinese clematis, profound Hu, the red sage root, radix bupleuri, Radix Isatidis, indigo naturalis relieves the pain.The present invention rises strong The effect of spleen removing toxic substances promoting blood circulation and removing obstruction in channels, puts righting in the first place, otherwise, clearing heat and detoxicating simply, most easy damaged middle-jiao yang, function of the spleen and stomach and there is abdominal distension Bitterly, vomiting, spiritlessness and sparing of words, the discomfort such as limbs fatigue, cause patient more painful and cannot adhere to treatment.
The present invention is only made up of said medicine, is constituted simply, and medicament sources are enriched, cheap；Treatment method is simple, only Need for oral administration, mitigation patient burden.And, patient only needs to take 1 dose of decoction of medicinal ingredients daily, takes and just substantially subtracts for 3 days or so Light pain, fully recovers by taking 7 days or so, instant effect.Additionally, the present invention single pair of Patients with Herpes Zoster is not effective in cure, and, if Patients with Herpes Zoster also suffers from other diseases simultaneously, such as malignant tumour or during diabetes, the present invention can also effectively treatment, and poison Small side effects, hence it is evident that mitigate patient suffering.
Further, single pair of Patients with Herpes Zoster is not effective in cure for the present invention, while can be controlled with effectively treatment bedsore and ulcer on the shank When bedsore and ulcer on the shank is treated, also take 1 dose of decoction of medicinal ingredients daily, take 2-3 days or so, the state of an illness is clearly better, take 5-7 days left sides Recovery from illness, instant effect by right, and toxic and side effect is little, hence it is evident that mitigate patient suffering.
With regard to above-mentioned preparation method, the water decoction is evaporated to concentration proportion for 1：1.05, be conducive to keeping drug effect, Ensure therapeutic effect.
The auxiliary material is starch, dextrin and/or sucrose, but not limited to this.It should be noted that the auxiliary material can also be joined Select according to prior art, its practical range is not limited to illustrated embodiment of the present invention.
The temperature of the low-temperature evaporation is 60-70 DEG C, and the wetting agent is 75-85% ethanol, is conducive to improving Chinese medicine Utilization rate, keeps drug effect, it is easy to absorb.
Wherein, the step of softwood being made bead dosage form with granulator includes：
Softwood is made wet grain with granulator, the water content of wet grain is 7-10%；
Wet grain is dried to bead dosage form by drying machine, the drying temperature of drying machine is 70-80 DEG C.
Using the preparation method of the Chinese herbal granules of the present invention, the utilization rate of Chinese medicine can be improved, make product dosage accurate Really, it is easy to absorb, rapid-action.
Below the present invention is produced further with specific embodiment
Embodiment 1
（One）Formula：Radix Astragali 30g, Radix Codonopsis 18g, bighead atractylodes rhizome 15g, licorice 6g, drought tuber of pinellia 10g, dried orange peel 10g, fructus amomi 10g, rhizoma cyperi 12g processed, Polygonum multiflower knotweed 30g, centipede 2, earthworm 15g, root of Chinese clematis 15g, profound Hu 10g, red sage root 30g, radix bupleuri 10g, Radix Isatidis 30g, adlay 30g, indigo naturalis 10g.
（Two）Preparation method：
The each raw material in addition to fructus amomi is weighed by formula, crush and mix；Medicinal material is added water to submerge, soaks 20-40min, heating 10-20min is decocted, then fructus amomi 5-15g is included, be fried boiling 5～10 min, the fried liquid of separation, after filtration, water decoction is steamed Send out, the water decoction is evaporated to concentration proportion for 1：1.05,1 times amount ethanol of cold rear addition, precipitation is placed, its supernatant is taken, Sediment is cleaned with 50%-60% ethanol again, and washing lotion is merged with filtrate, after decompression recycling ethanol, is filtered, and filtrate low-temperature evaporation is extremely Paste, the temperature of low-temperature evaporation is 60 DEG C, and it is 1.30-1.40 that the proportion typically heat of thick paste surveys (80-90 DEG C), is soaked Cream；After medicinal extract and auxiliary materials and mixing, plus softwood made by wetting agent；Softwood is made wet grain with granulator, the water content of wet grain is 7%；Wet grain is dried to bead dosage form by drying machine, the drying temperature of drying machine is 70 DEG C, packs.
Embodiment 2
（One）Formula：Radix Astragali 30g, Radix Codonopsis 20g, bighead atractylodes rhizome 18g, licorice 8g, drought tuber of pinellia 12g, dried orange peel 10g, fructus amomi 10g, rhizoma cyperi 12g processed, Polygonum multiflower knotweed 30g, centipede 2, earthworm 15g, root of Chinese clematis 15g, profound Hu 10g, red sage root 30g, radix bupleuri 10g, Radix Isatidis 30g, adlay 35g, indigo naturalis 12g.
（Two）Preparation method：
The each raw material in addition to fructus amomi is weighed by formula, crush and mix；Medicinal material is added water to submerge, soaks 20-40min, heating 10-20min is decocted, then fructus amomi 5-15g is included, be fried boiling 5～10 min, the fried liquid of separation, after filtration, water decoction is steamed Send out, the water decoction is evaporated to concentration proportion for 1：1.05,2 times amount ethanol of cold rear addition, precipitation is placed, its supernatant is taken, Sediment is cleaned with 50%-60% ethanol again, and washing lotion is merged with filtrate, after decompression recycling ethanol, is filtered, and filtrate low-temperature evaporation is extremely Paste, the temperature of low-temperature evaporation is 65 DEG C, and it is 1.30-1.40 that the proportion typically heat of thick paste surveys (80-90 DEG C), is soaked Cream；After medicinal extract and auxiliary materials and mixing, plus softwood made by wetting agent；Softwood is made wet grain with granulator, the water content of wet grain is 8%；Wet grain is dried to bead dosage form by drying machine, the drying temperature of drying machine is 72 DEG C, packs.
Embodiment 3
（One）Formula：Radix Astragali 20g, Radix Codonopsis 10g, bighead atractylodes rhizome 10g, licorice 1g, drought tuber of pinellia 5g, dried orange peel 5g, fructus amomi 5g, system Rhizoma cyperi 7g, Polygonum multiflower knotweed 20g, centipede 1, earthworm 10g, root of Chinese clematis 10g, profound Hu 5g, red sage root 20g, radix bupleuri 5g, Radix Isatidis 20g, adlay 20g, indigo naturalis 5g.
（Two）Preparation method：
The each raw material in addition to fructus amomi is weighed by formula, crush and mix；Medicinal material is added water to submerge, soaks 20-40min, heating 10-20min is decocted, then fructus amomi 5-15g is included, be fried boiling 5～10 min, the fried liquid of separation, after filtration, water decoction is steamed Send out, the water decoction is evaporated to concentration proportion for 1：1.05,1 times amount ethanol of cold rear addition, precipitation is placed, its supernatant is taken, Sediment is cleaned with 50%-60% ethanol again, and washing lotion is merged with filtrate, after decompression recycling ethanol, is filtered, and filtrate low-temperature evaporation is extremely Paste, the temperature of low-temperature evaporation is 60 DEG C, and it is 1.30-1.40 that the proportion typically heat of thick paste surveys (80-90 DEG C), is soaked Cream；After medicinal extract and auxiliary materials and mixing, plus softwood made by wetting agent；Softwood is made wet grain with granulator, the water content of wet grain is 9%；Wet grain is dried to bead dosage form by drying machine, the drying temperature of drying machine is 75 DEG C, packs.
Embodiment 4
（One）Formula：Radix Astragali 40g, Radix Codonopsis 25g, bighead atractylodes rhizome 20g, licorice 10g, drought tuber of pinellia 15g, dried orange peel 15g, fructus amomi 15g, Rhizoma cyperi 18g processed, Polygonum multiflower knotweed 40g, centipede 3, earthworm 20g, root of Chinese clematis 20g, profound Hu 15g, red sage root 40g, radix bupleuri 15g, plate are blue Root 40g, adlay 40g, indigo naturalis 15g.
（Two）Preparation method：
The each raw material in addition to fructus amomi is weighed by formula, crush and mix；Medicinal material is added water to submerge, soaks 20-40min, heating 10-20min is decocted, then fructus amomi 5-15g is included, be fried boiling 5～10 min, the fried liquid of separation, after filtration, water decoction is steamed Send out, the water decoction is evaporated to concentration proportion for 1：1.05,2 times amount ethanol of cold rear addition, precipitation is placed, its supernatant is taken, Sediment is cleaned with 50%-60% ethanol again, and washing lotion is merged with filtrate, after decompression recycling ethanol, is filtered, and filtrate low-temperature evaporation is extremely Paste, the temperature of low-temperature evaporation is 70 DEG C, and it is 1.30-1.40 that the proportion typically heat of thick paste surveys (80-90 DEG C), is soaked Cream；After medicinal extract and auxiliary materials and mixing, plus softwood made by wetting agent；Softwood is made wet grain with granulator, the water content of wet grain is 10%；Wet grain is dried to bead dosage form by drying machine, the drying temperature of drying machine is 80 DEG C, packs.
Patient is treated with embodiment 1-4, specific as follows：
Patient A：Female, 45 years old, there is the papulo-vesicle of the soya bean size of cluster and blister in the violent shouting pain of left lumbar region, next day patient, really Examine as herpes zoster.Through ACV, vitamin B12, C16H25NO2 etc. is treated 10 days, and patient's still hurt like hell, left lumbar region are still acute Strong pain, it is impossible to ortho, an urgent demand pain relieving, need to be assisted in by other people could walking reluctantly（Premorbid is walked freely）, companion Spiritlessness and weakness, spontaneous perspiration, nausea, receive difference, nothing stool on the 5th.Have a medical check-up：Cardiopulmonary are normal, and left lumbar region fash is in zonal distribution, blister part Break, tongue nature is light, corpulent tongue, pale greasy, deeptensepulse is powerless.B ultrasonic shows：Double kidneys, ureter, bladder no abnormality seen.Patient A is simultaneously Also suffer from bedsore, ulcer on the shank.
Patient B：Female, 39 years old, there is the mound blister of the soya bean size of cluster in violent shouting pain around neck and face, next day patient Rash and blister, are diagnosed as herpes zoster.Through ACV, vitamin B12, C16H25NO2 etc. is treated 10 days, patient's still hurt like hell, Still have an intense pain around neck and face, it is impossible to ortho, an urgent demand pain relieving, need to be assisted in by other people could walking reluctantly （Premorbid is walked freely）, with spiritlessness and weakness, spontaneous perspiration, nausea, receive difference, nothing stool on the 3rd.Have a medical check-up：Cardiopulmonary are normal, neck and face Surrounding fash is in zonal distribution, and blister part is broken, and tongue nature is light, corpulent tongue, and pale greasy, deeptensepulse is powerless.B ultrasonic shows：Double kidneys, defeated Urinary catheter, bladder no abnormality seen.Patient B also suffers from tumor of breast, ulcer on the shank simultaneously.
Patient C：Man, 41 years old, violent shouting pain around waist and belly, next day patient occur the soya bean size of cluster papulo-vesicle and Blister, is diagnosed as herpes zoster.Through ACV, vitamin B12, C16H25NO2 etc. is treated 10 days, patient's still hurt like hell, waist abdomen Portion still has an intense pain, it is impossible to ortho, an urgent demand pain relieving, and need to be assisted in by other people could walking reluctantly（Premorbid walking is certainly Such as）, with spiritlessness and weakness, spontaneous perspiration, nausea, receive difference, nothing stool on the 7th.Have a medical check-up：Cardiopulmonary are normal, and waist and belly fash is in zonal distribution, water Blister part is broken, and tongue nature is light, corpulent tongue, and pale greasy, deeptensepulse is powerless.B ultrasonic shows：Double kidneys, ureter, bladder no abnormality seen.Disease People C also suffers from bedsore simultaneously.
Patient D：Man, 56 years old, violent shouting pain around right lumbar region, next day patient occur the soya bean size of cluster papulo-vesicle and Blister, is diagnosed as herpes zoster.Through ACV, vitamin B12, C16H25NO2 etc. is treated 10 days, patient's still hurt like hell, right waist Portion still has an intense pain, it is impossible to ortho, an urgent demand pain relieving, and need to be assisted in by other people could walking reluctantly（Premorbid walking is certainly Such as）, with spiritlessness and weakness, spontaneous perspiration, nausea, receive difference, nothing stool on the 4th.Have a medical check-up：Cardiopulmonary are normal, and right lumbar region fash is in zonal distribution, water Blister part is broken, and tongue nature is light, corpulent tongue, and pale greasy, deeptensepulse is powerless.B ultrasonic shows：Double kidneys, ureter, bladder no abnormality seen.Disease People D also suffers from diabetes simultaneously.
The medicine of embodiment 1-4 is treated to patient A, B, C, D respectively, as a result as follows：
.
From the foregoing, it will be observed that the present invention single pair of Patients with Herpes Zoster is not effective in cure, toxic and side effect is little, hence it is evident that mitigate patient suffering. And, if Patients with Herpes Zoster is while also suffer from other diseases, such as malignant tumour or during diabetes, the present invention effectively can also be controlled Treat, and toxic and side effect is little, hence it is evident that mitigate patient suffering.It is also possible to effectively treatment bedsore and ulcer on the shank, instant effect, Fully recover by taking 5-7 days or so, instant effect, and toxic and side effect is little, hence it is evident that mitigate patient suffering.Should finally illustrate It is that above example is only in order to illustrate technical scheme rather than limiting the scope of the invention, although reference is relatively Good embodiment is explained in detail to the present invention, it will be understood by those within the art that, can be to the technology of the present invention Scheme is modified or equivalent, without deviating from the spirit and scope of technical solution of the present invention.

Claims (8)

1. a kind of Chinese herbal granules of invigorating the spleen Tongluo Jiedu, it is characterised in that the formula of the Chinese herbal granules is：
Radix Astragali 20-40g, Radix Codonopsis 10-25g, bighead atractylodes rhizome 10-20g, licorice 1-10g, drought tuber of pinellia 5-15g, dried orange peel 5-15g, sand Benevolence 5-15g, rhizoma cyperi 7-18g processed, Polygonum multiflower knotweed 20-40g, centipede 1-3 bar, earthworm 10-20g, root of Chinese clematis 10-20g, profound Hu 5- 15g, red sage root 20-40g, radix bupleuri 5-15g, Radix Isatidis 20-40g, adlay 20-40g, indigo naturalis 5-15g；
The Chinese herbal granules are obtained by following methods：Each raw material is weighed by formula, crush and mix；Add water to submerge medicinal material Heating is decocted afterwards, the fried liquid of separation, after filtration, water decoction is evaporated, cold rear addition 1-2 times amount ethanol, is placed precipitation, is taken which Supernatant, sediment are cleaned with ethanol again, and washing lotion merges with filtrate, after decompression recycling ethanol, filtration, and filtrate low-temperature evaporation is to thick Paste, obtains medicinal extract；After medicinal extract and auxiliary materials and mixing, plus softwood made by wetting agent；Softwood is made bead dosage form with granulator, Pack.
2. Chinese herbal granules as claimed in claim 1, it is characterised in that the formula of the Chinese herbal granules is：
Radix Astragali 25-35g, Radix Codonopsis 15-20g, bighead atractylodes rhizome 12-18g, licorice 3-8g, drought tuber of pinellia 7-12g, dried orange peel 8-12g, sand Benevolence 8-12g, rhizoma cyperi 10-15g processed, Polygonum multiflower knotweed 25-35g, centipede 2-3 bar, earthworm 12-18g, root of Chinese clematis 12-18g, profound Hu 7-12g, red sage root 25-35g, radix bupleuri 8-12g, Radix Isatidis 25-35g, adlay 25-35g, indigo naturalis 8-12g.
3. Chinese herbal granules as claimed in claim 2, it is characterised in that the formula of the Chinese herbal granules is：
Radix Astragali 30g, Radix Codonopsis 18g, bighead atractylodes rhizome 15g, licorice 6g, drought tuber of pinellia 10g, dried orange peel 10g, fructus amomi 10g, rhizoma cyperi processed 12g, Polygonum multiflower knotweed 30g, centipede 2, earthworm 15g, root of Chinese clematis 15g, profound Hu 10g, red sage root 30g, radix bupleuri 10g, Radix Isatidis 30g, Adlay 30g, indigo naturalis 10g.
4. Chinese herbal granules as claimed in claim 1, it is characterised in that described water decoction is evaporated to concentration proportion for 1 ：1.05.
5. Chinese herbal granules as claimed in claim 1, it is characterised in that the auxiliary material is starch, dextrin and/or sucrose.
6. Chinese herbal granules as claimed in claim 1, it is characterised in that the temperature of the low-temperature evaporation is 60-70 DEG C.
7. Chinese herbal granules as claimed in claim 1, it is characterised in that the wetting agent is 75-85% ethanol.
8. Chinese herbal granules as claimed in claim 1, it is characterised in that the step of softwood is made bead dosage form with granulator Including：
Softwood is made wet grain with granulator, the water content of wet grain is 7-10%；
Wet grain is dried to bead dosage form by drying machine, the drying temperature of drying machine is 70-80 DEG C.
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CN106421614A (en) * 2016-11-17 2017-02-22 佛山科学技术学院 Spleen-invigorating, collateral-dredging and detoxifying traditional Chinese medicinal capsule
CN106421613A (en) * 2016-11-17 2017-02-22 佛山科学技术学院 Spleen-invigorating, collateral-dredging and detoxifying traditional Chinese medicinal composition and preparation method and traditional Chinese medicinal preparation thereof
CN106474415A (en) * 2016-11-17 2017-03-08 佛山科学技术学院 A kind of medicine pill of invigorating the spleen Tongluo Jiedu
CN106474414A (en) * 2016-11-17 2017-03-08 佛山科学技术学院 A kind of Chinese herbal granules of invigorating the spleen Tongluo Jiedu

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谢海清 等: "健脾通络解毒法治疗老年带状疱疹后遗神经痛30例临床体会", 《四川中医》 *

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018090848A1 (en) * 2016-11-17 2018-05-24 佛山科学技术学院 Chinese medicine granule for invigorating spleen, removing obstruction in collaterals and detoxification

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