CN106474230A - Chinese medicine composition of preventing and treating Rana grylia torticollis disease and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of Chinese medicine composition of preventing and treating Rana grylia torticollis disease, it is made up of the crude drug of following masses part proportioning：170 210 parts of Radix Et Rhizoma Rhei, 50 80 parts of Concha Haliotidis, 190 220 parts of toothed burclover, 180 215 parts of the Radix Astragali, 180 210 parts of Myrrha, 80 110 parts of Folium Artemisiae Argyi, 130 165 parts of Herba Salviae Chinensiss, 185 215 parts of Fructus Gardeniae, 105 135 parts of Herba Asari, 210 245 parts of Fructus Aurantii, 105 140 parts of Fructus Gleditsiae Abnormalis, 135 160 parts of the Radix Paeoniae Alba, 120 150 parts of Herba Paederiae.In this medicine there is not incompatibility in each material combination, can substantially reduce the incidence rate of Rana grylia torticollis disease, have good preventive and therapeutic action to Rana grylia torticollis disease, and have no toxic side effect, using safety, no hazardous drugs residual.

Description

Chinese medicine composition of preventing and treating Rana grylia torticollis disease and preparation method thereof

Technical field

The invention belongs to Rana nigromaculata cultural technique field and in particular to a kind of preventing and treating Rana grylia torticollis disease Chinese medicine composition And preparation method thereof.

Background technology

Rana grylia also known as the river frog, Hylarana guentheri.Originate in the U.S., the later stage eighties 20th century introduces China, its fine and tender taste, Delicious flavour, is first-class Rana esculenta, has promoted cultivation throughout the country.Rana grylia has that individual big, growth is fast, taste Delicious, protein content is high, is a kind of high-quality and efficient economic cultivation batrachia.Fierce, some old raisers with industry competition Cultural technique old stuff, leads to produce effect lowly, some can't regain one's original capital, and some cultivation are not stinted using some forbidden drugs, lead to Rana nigromaculata Internal harmful substance accumulation, thus leading to mortality, also makes cultivation water suffer severe contamination, also ecological around collateral damage Environment.

In breeding process, large-scale cultivation is susceptible to disease to Rana grylia, and is very easy to spread, mainly There is following disease：Tadpole period Common Diseases：Torticollis disease, septicemia, enteritis, fish moldss, ascites, trichodinasis, gas bubble disease；Become the frog normal See disease：Enteritis, red leg disease, infectious liver disease, white-eyes-sickness, bark rot etc., by putting into practice, exploring, Experimental comparison, take with pre- Based on anti-.

Wherein Rana grylia torticollis disease is that this bacterium directly destroys the cranial nerve of the frog caused by meningitiss deteriorated blood Flavobacterium, Cause mentally deranged generation torticollis.The ill frog is ceaselessly spinned in water, askew turn to the left or to the right of its head.Sick frog food ration subtracts Few, mortality rate is high, if processing the sick frog not in time, it will so that frog group is infected.Main infection mode has two kinds, and one is directly from parent To filial generation, two is mutual infection.

Preventing and treating Rana grylia torticollis disease with the following method is typically adopted in prior art, 1) tadpole period is monthly or first quarter moon furan 0.1-l gram of oxazolone is mixed l kilogram of material and is fed, and the young frog feeds with becoming frog sulfonamides mix fodder, such as sulfadiazine（SD）Per kilogram With 0.2 gram, halves the frog for 2-7 days within 1st day.These medicines are Western medicine, easily cause drug dependence, or impact Rana nigromaculata meat Matter prevents and treats the sick Chinese medicine composition of Rana grylia torticollis it is therefore necessary to exploitation is a kind of.

Content of the invention

It is an object of the invention to overcoming the deficiencies in the prior art, provide a kind of Chinese medicine group of preventing and treating Rana grylia torticollis disease Compound, in medicine there is not incompatibility in each material combination, can substantially reduce the incidence rate of Rana grylia torticollis disease, blue or green to the U.S. Frog torticollis disease has good preventive and therapeutic action, and has no toxic side effect, using safety, no hazardous drugs residual.

The technical solution adopted for the present invention to solve the technical problems is：

The technical scheme is that：A kind of Chinese medicine composition of preventing and treating Rana grylia torticollis disease, it is to be joined by following masses part The crude drug of ratio is made：Radix Et Rhizoma Rhei 170-210 part, Concha Haliotidis 50-80 part, toothed burclover 190-220 part, Radix Astragali 180-215 part, Myrrha 180-210 part, Folium Artemisiae Argyi 80-110 part, Herba Salviae Chinensiss 130-165 part, Fructus Gardeniae 185-215 part, Herba Asari 105-135 part, Fructus Aurantii 210-245 Part, Fructus Gleditsiae Abnormalis 105-140 part, Radix Paeoniae Alba 135-160 part, Herba Paederiae 120-150 part.

Its further preferred mass part proportioning is：Radix Et Rhizoma Rhei 170-205 part, Concha Haliotidis 50-75 part, toothed burclover 190-215 part, the Radix Astragali 190-215 part, Myrrha 185-210 part, Folium Artemisiae Argyi 80-105 part, Herba Salviae Chinensiss 130-160 part, Fructus Gardeniae 185-210 part, Herba Asari 105-130 Part, Fructus Aurantii 210-240 part, Fructus Gleditsiae Abnormalis 110-140 part, Radix Paeoniae Alba 140-160 part, Herba Paederiae 125-150 part.

Its further preferred mass part proportioning is：Radix Et Rhizoma Rhei 180-205 part, Concha Haliotidis 50-70 part, toothed burclover 190-210 part, the Radix Astragali 190-210 part, Myrrha 190-210 part, Folium Artemisiae Argyi 90-105 part, Herba Salviae Chinensiss 140-160 part, Fructus Gardeniae 190-210 part, Herba Asari 110-130 Part, Fructus Aurantii 220-240 part, Fructus Gleditsiae Abnormalis 120-140 part, Radix Paeoniae Alba 145-160 part, Herba Paederiae 130-150 part.

Its further preferred mass part proportioning is：Radix Et Rhizoma Rhei 190-205 part, Concha Haliotidis 55-70 part, toothed burclover 190-205 part, Radix Astragali 195-210 part, Myrrha 190-205 part, Folium Artemisiae Argyi 95-105 part, Herba Salviae Chinensiss 140-155 part, Fructus Gardeniae 190-205 part, Herba Asari 110- 125 parts, Fructus Aurantii 220-235 part, Fructus Gleditsiae Abnormalis 120-135 part, Radix Paeoniae Alba 145-155 part, Herba Paederiae 135-150 part.

Its further preferred mass part proportioning is：Radix Et Rhizoma Rhei 190-200 part, Concha Haliotidis 60-70 part, toothed burclover 190-200 part, Radix Astragali 200-210 part, Myrrha 190-200 part, Folium Artemisiae Argyi 100-105 part, Herba Salviae Chinensiss 150-155 part, Fructus Gardeniae 200-205 part, Herba Asari 110-120 part, Fructus Aurantii 220-230 part, Fructus Gleditsiae Abnormalis 130-135 part, Radix Paeoniae Alba 145-150 part, Herba Paederiae 140-150 part.

Its further preferred mass part proportioning is：200 parts of Radix Et Rhizoma Rhei, 60 parts of Concha Haliotidis, 200 parts of toothed burclover, 200 parts of the Radix Astragali, 200 parts of Myrrha, 100 parts of Folium Artemisiae Argyi, 150 parts of Herba Salviae Chinensiss, 200 parts of Fructus Gardeniae, 120 parts of Herba Asari, 230 parts of Fructus Aurantii, 130 parts of Fructus Gleditsiae Abnormalis, the Radix Paeoniae Alba 150 Part, 140 parts of Herba Paederiae.

The primary raw material medicine that the present invention uses is described as follows：

Radix Et Rhizoma Rhei:Radix Et Rhizoma Rhei is being collectively referred to as of the perennial plant of multiple Polygonaceae Rheums, is also the title of Chinese crude drug.Radix Et Rhizoma Rhei of the present invention Refer to todaiwo,rhizoma.Excavation before autumn Mo stem and leaf is withered or secondary spring is germinateed.Remove radicula, scrape off crust, valve cutting or section, rope is worn into String is dried or convection drying, and Chinese herb rhubarb has attacks the effects such as stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, removing toxic substances.

Concha Haliotidis：Shell for Bao Ke animal Haliotis diversicolor, haliotis discus hannai Ino, ear Bao, sheep Bao etc..Also known as natural pearls are female（《Thunder God big gun Process opinion》）, Carnis Haliotidiss first（《Collective Notes to Canon of Materia Medica》）, nine hole spiral shells（《Japan hanako materia medica》）, Herba Senecionis Scandentiss（《Detailed outline》）, very sea certainly, Hai Jue Bright, CONCHA HALIOTIDI, abalone shells, nine hole Concha Haliotidis（《Pharmacognosy》）, Carnis Haliotidiss skin（《Shandong Chinese medicine handbook》）, golden Carnis Mactrae skin（《In Shandong Medical herbs》）.There are calming liver and clearing heat, effect of improving eyesight removing nebula.This product is conventional Chinese medicine, and " Mingyi Bielu " is classified as top grade.Modern commercially available product is divided Determine for light bottom sea, certainly determine three kinds with sea in hair bottom sea.Former animal is determined for haliotis diversicolor Reeve in light bottom sea, and certainly former animal is that disk is big in hair bottom sea Bao, sea former animal certainly is sheep Bao.Other title natural pearls are female, Carnis Haliotidiss first, nine hole spiral shells, Herba Senecionis Scandentiss, Carnis Haliotidiss skin, golden Carnis Mactrae skin.

Toothed burclover:It is the address to Herba Loti Tenuis for the people on the ground such as Shanghai, granary, Changshu.Herba Loti Tenuis, original name south lucerne vegetables MedicagohispidaGaertn has Ye Sanchi, such as reversed cardioid, and sawtooth is arranged at tip slightly circle or recessed top, and the surface of leaf is in dense Green, stalk is extremely short, and main root is long, multi-branched.Stem is generally vertical, closely no hair, high 30-100 centimetre.Compound leaf has 3 lobules, lobule Obovate or lanceolar, long 1-2 centimetre, wide about 0.5 centimetre, nose-circle, middle rib slightly protrudes, and first half leaf has sawtooth, base portion Narrow wedge shape；Stipule narrow lanceolar, full edge.Raceme axil is given birth to, flower 8-25.Pod spiral type, stingless, top has point to expose nozzle；? Jiangsu and Zhejiang Provinces two province produces special many.Toothed burclover be leguminous plant, often eat toothed burclover element can balanced human pH-value.

The Radix Astragali：Also known as silk floss stilbene.Perennial herb is high 50-100 centimetre.Main root is plump, wooden, normal branch, canescence.Stem Uprightly, top multi-branched, has thin rib, by white pubescence.Perennial herb is high 50-100 centimetre.Originate in Inner Mongol, Shanxi, sweet The ground such as respectful, Heilungkiang.The medicinal history having more than 2000 year so far of the Radix Astragali, it has enhancing human body immunity function, liver protection, profit Urine, defying age, anti-stress, blood pressure lowering and wide antibacterial action.But table excess pathogen contain, retention of dampness due to stagnation of QI, food stagnation stagnate, carbuncle from the beginning of Or the excess syndrome such as pyretic toxicity Shang Sheng after bursting, and hyperactivity of YANG due to deficiency of YIN person, clothes must be prohibited.

Myrrha：Chinese medicine name, is olive subject plant Herba Violae tree Commiphora myrrha Engl. or Ha Didingshu The dry resin of Commiphora molmol Engl..It is divided into natural Myrrha and gum opoponax.It is distributed in Somalia, Ethiopia Russia Than Asia and Arabia Peninsula south and other places.There is the effect of scattered stasis pain, detumescence and promoting granulation.It is usually used in obstruction of qi in the chest and cardialgia, gastralgia, Dysmenorrhea amenorrhea, postpartum stagnation, abdominal mass is suffered from abdominal pain, rheumatic arthralgia, traumatic injury, the treatment of the disease such as carbuncle swells sore.

Folium Artemisiae Argyi：Perennial herb or slightly one-tenth suffruticose, plant has enhanced aroma.The life of stem list or minority, brown or sallow Brown, base portion slightly lignifying, top Bi matter, and have the short branch of minority, leaf ground paper matter, above by canescence pubescence, base portion Usual no pseudostipule or minimum pseudostipule；Upper leaf and bract leaf pinniform are partly split, head inflorescence ellipse, corolla tubulose or height Foot cup-shaped, there is gland point outside, and flower pesticide is narrow linear, and style and corolla be closely isometric or slightly longer than corolla.Achene long avette or Long Circle. The flowering fruit bearing stage 9-10 month.All herbal medicine, have warming the meridian, dry, cold expelling, hemostasis, antiinflammatory, relieving asthma, cough-relieving, the effect such as antiabortive, antiallergic. Folium Artemisiae Argyi is dried and smashs to pieces " Folium Artemisiae Argyi ", and moxa roll processed, for moxa-moxibustion, can make the raw material of " ink paste " again.

Herba Salviae Chinensiss：Also known as：Dali Radix Rubiae, Rubiayunnanensis (Franch.) Dlels, Arisaema balansae Engl., dice piece etc., genus rubia mesh, Rubiaceae draft；Indication： Heat-clearing and toxic substances removing, blood circulation promoting regulates qi pain relieving.Swell for acute, chronic hepatitis, gastral cavity side of body distending pain, damp-heat vaginal discharge, mastitis, furuncle.

Fructus Gardeniae：Another name Yellow Fructus Gardeniae, Fructus Gardeniae, white toad, Flos Gardeniae, are the fruits of Maguireothamnus speciosus Fructus Gardeniae.Genus rubia section, Fructus Gardeniae Belong to, evergreen shrubss；Root, leaf, fruit all can be used as medicine, and have the effect of purging intense heat relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body；Effect：Clearly Lung cough-relieving, cooling blood for hemostasis, pathogenic fire purging, cure mainly cough due to lung-heat, cough up phlegm, toxic swelling, control calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quench one's thirst, mesh Red, pharyngalgia, spit blood, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprain and swell and ache.《Dictionary of medicinal plant》Described in：Fructus Gardeniae, different name：Wood Red (《This warp》), fresh (《Upper woods is assigned》), ancient wine vessel (《Chinese book》Meng Kang note), more Fructus Persicae (《Do not record》), stand (《Collective Notes to Canon of Materia Medica》), SHANZHIZI (《Haigoushen》), Fructus Gardeniae (《Newly Revised Canon of Materia Medica》), little danger son (《Book on Chinese herbal medicine is original》), Huang sprout (《Fujian east book on Chinese herbal medicine》), yellow Cape jasmine Son (《Jiangsu medical material will》), yellow Cape jasmine, gardenia jasminoides ellis, Fructus Gardeniae (《Zhejiang medicinal plants will》)；For Rubiaceae Fructus Gardeniae platymiscium Fructus Gardeniae Fruit.

Herba Asari；Another name：Asarum sieboldii, basin grass Herba Asari, Aristolochiaceae, asarum perennial herb；Herba Asari as medicinal plants, Shi Zai Qin Han《Sheng Nong's herbal classic》,《Sheng Nong's herbal classic》It is classified as top grade.Herba Asari root is thin, color sallow, leaf color are green, and acrid in the mouth is peppery Numb tongue.Warm in nature, slightly poisonous.GUIXIN, lung, kidney channel.There are wind-dispelling, cold expelling, warming the lung, Hang Shui, the effect having one's ideas straightened out.Control headche due to wind-cold, nose Deep pool, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.Additionally, Herba Asari also has anti inflammatory immunity, Herba Asari local anesthesia, improves newly old generation Thank, antibacterial action, also can be used for the leukopenia of Chemotherapy of Tumor Patients and caused by radiation.

Fructus Aurantii:Medicinal originate as rutaceae Citrus aurantium Linn. and its variety immature fruit is dried.July peel is still Harvest when green, from middle part crosscutting for two halves, dry or cold drying.Fructus Aurantii property is bitter, pungent, sour, warm, have regulating the flow of QI to ease the stomach, row stagnant Effect of relieving distension, cures mainly the chest side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention;Gastroptosis, proctoptosis, the disease such as sub-official prolapses Disease.

Fructus Gleditsiae Abnormalis：Also known as：Fructus Gleditsiae Abnormalis.It is the injured rear small-sized fruit tied of leguminous plant Fructus Gleditsia plant, bend to crescent. The flat elder of shape, referred to as big Fructus Gleditsia（I.e. Fructus Gleditsia）.Containing triterpenoid saponin, tannin, ceryl alcohol, nonacosane, stigmasterol etc..There is eliminating the phlegm, urge Tell, the effect such as diarrhea inducing.

The Radix Paeoniae Alba：Also referred to as Paeonia sterniana Fletcher in Journ., is Ranunculaceae Radix Paeoniae platymiscium.In the existing long cultivation history of China, in being renown far and wide Outward, it claims Paeonia sterniana Fletcher in Journ..Its root can be used as medicine.Smooth liver and relieve pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating.For dizziness of having a headache, hypochondriac pain, suffer from abdominal pain, Limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.

Herba Paederiae：Herba Paederiae refers generally to fevervine, is the herb of Maguireothamnus speciosus fevervine, and summer harvests herb, dries. Its sweet in the mouth, slight bitter, mild-natured.There is the effect of expelling wind and removing dampness, analgesic antidotal, promoting digestion and removing stagnation, promoting blood circulation and detumescence.For rheumatism muscles and bones Bitterly, traumatic injury, traumatic pain, liver and gall and stomach intestinal colic, dyspepsia, infantile malnutrition, bronchitis；It is used for dermatitis outward, Eczema and sore swollen toxin.

In the medicine of the present invention there is not incompatibility in each material combination, can substantially reduce the generation of Rana grylia torticollis disease Rate, has good preventive and therapeutic action to Rana grylia torticollis disease, and has no toxic side effect, using safety, no hazardous drugs Residual.

It is a further object of the present invention to provide a kind of preparation method of said medicine, its process is simple, its crude drug is common, Cheaply.

The preparation method of medicine of the present invention is as follows：

The first step:Calculate the raw material weight of batch production by formula proportion；

Second step:The raw material calculating batch production is positioned in stirring container, be soaked in water 3-5 hour, wherein the use of water Measure 30 times for Chinese medicine gross weight, warm fire heats burning to seething with excitement, and endures 15-20 minute, then after insulation 3 hours, then warm fire is heated burning To seething with excitement, endure 25-30 minute；

3rd step:Carry out centrifugal filtration, filtrate through 2-3 hour precipitation after, second centrifugal filtration；Filtrate is this The medicine of bright preventing and treating Rana grylia torticollis disease.

The medicine using method of the present invention：Become the frog phase, when feeding every time, every 10 kg diet, weigh 1000 grams of preventing and treatings beautiful The Chinese medicine composition filtrate of state's Rana nigromaculata torticollis disease, adds 50 grams of brown sugar in Chinese medicine composition filtrate, is subsequently adding feedstuff In, mix all, feed immediately, the daily morning and evening respectively feeds once, free choice feeding, be within 10 days a course for the treatment of, can feed every 10 days One course for the treatment of of this medicine, froglet phase medicine halves.

In order to be illustrated more clearly that the present invention, enumerate following examples, but it is without any restrictions to the scope of invention.

Specific embodiment

Embodiment 1

Weigh Radix Et Rhizoma Rhei 200g, Concha Haliotidis 60g, toothed burclover 200g, Radix Astragali 200g, Myrrha 200g, Folium Artemisiae Argyi 100g, Herba Salviae Chinensiss 150g, Fructus Gardeniae 200g, Herba Asari 120g, Fructus Aurantii 230g, Fructus Gleditsiae Abnormalis 130g, Radix Paeoniae Alba 150g, Herba Paederiae 140g, these material compositions are through drying Quality afterwards；

The first step:Calculate the raw material weight of batch production by formula proportion；

Second step:The raw material calculating batch production is positioned in stirring container, is soaked in water 4 hours, wherein the consumption of water For Chinese medicine gross weight 30 times；Warm fire is heated and is burnt to seething with excitement, and endures 20 minutes, and after being then incubated 3 hours, then warm fire is heated to burn and extremely boiled Rise, endure 30 minutes；

3rd step:Carry out centrifugal filtration, filtrate through 2 hours precipitation after, second centrifugal filtration；Filtrate is the present invention The medicine of preventing and treating Rana grylia torticollis disease.

Embodiment 2-14

Embodiment 2-12 in addition to raw material mass mixture ratio is different from embodiment 1, its raw material type and step of preparation process and use Method is identical with embodiment 1, and comparative example 1 is to eliminate Myrrha on the basis of embodiment 1, and comparative example 2 is in embodiment 1 On the basis of eliminate Herba Salviae Chinensiss, the raw material that embodiment 1-12, comparative example 1-2 are used and quality as shown in Table 1 below, below Table 1 shows the raw material and quality that embodiment 1-12, comparative example 1-2 used.

Table 1

Clinical trial one：

(1) laboratory animal

Select 300 Rana grylia suffering from torticollis disease to become the frog, loss of appetite, be reluctant activity；

(2) experimental technique

Random packet, is divided into 15 groups, every group 20, wherein 14 groups is experimental group, respectively feeding embodiment 1-12, comparative example The feedstuff that medicine described in 1-2 is made into, daily 2 times, free choice feeding, continuous 10 days；Another group is matched group, using prior art Sulfadiazine therapy, feeds according still further to normal feed mode.Treatment is observed and is made a record for 10 days afterwards.Specifically it is shown in Table 2；

(3) treatment standard and observational technique

Cure：Torticollis disease recovery from illness；

Effectively：Torticollis disease is effectively alleviated, and has very big alleviation；

Invalid：Torticollis disease is not effectively alleviated.

Table 2

	Cure number	Significant figure	Invalid number
				Embodiment 1	20	0	0
Embodiment 2	19	1	0
				Embodiment 3	18	1	1
Embodiment 4	20	0	0
				Embodiment 5	19	1	0
Embodiment 6	18	1	1
				Embodiment 7	19	1	0
Embodiment 8	18	1	1
				Embodiment 9	20	0	0
Embodiment 10	19	1	0
				Embodiment 11	18	1	1
Embodiment 12	17	1	2
				Comparative example 1	13	2	5
Comparative example 2	12	4	4
				Matched group	10	2	8

It follows that in the case of equal consumption, it is right that the therapeutic effect that is mixed into using medicine of the present invention in feedstuff is substantially better than Ratio and matched group.And after 1 month, experimental group is 0 recurrence, and contrast groups have 4 recurrences.

Clinical trial two：

In order to prove the feeding effect to Rana grylia for the present invention, repeatedly tried feeding experiment, choose large-scale Rana grylia and support Grow the Rana grylia that field 3000 is only in into the frog phase, body weight size, health status are basically identical, be randomly divided into 15 groups, every group 200 Only.Wherein 14 groups is experimental group, the feedstuff that feeding embodiment 1-12, medicine described in comparative example 1-2 are made into respectively, twice daily, Free choice feeding, continuous 10 days；Feed one course for the treatment of of this medicine every 10 days.Another group is matched group, and feeding is not added with the identical of medicine Feedstuff, the nursing number of times of 15 groups of Rana nigromaculatas, feeding volume, nursing time all same.Contrast the various performance indications of 15 groups of Rana nigromaculatas, averagely Value such as table 3.

After 1 month, 15 groups of Rana nigromaculata situation such as tables 3：

Table 3

	Suffer from torticollis disease number	Moon weightening (g)/only
			Embodiment 1	0	129
Embodiment 2	3	120
			Embodiment 3	2	125
Embodiment 4	0	126
			Embodiment 5	0	131
Embodiment 6	0	132
			Embodiment 7	0	126
Embodiment 8	0	127
			Embodiment 9	0	125
Embodiment 10	0	128
			Embodiment 11	0	127
Embodiment 12	0	129
			Comparative example 1	20	110
Comparative example 2	30	100
			Matched group	70	95

Can be evident that from table, after the medicine that the continuous feeding present invention provides, daily gain is more right for experimental group Rana nigromaculata Increase substantially according to group, and experimental group relatively matched group honey stomach, energetic, state is good, and no any other disease occurs.

So the present invention be not limited to as preventing and treating Rana grylia torticollis disease Chinese medicine composition, as long as composition of raw materials with The identical or equivalent medicine of the present invention just falls within the scope and spirit of the invention.Will be askew with the preventing and treating Rana grylia of the present invention The raw material of the Chinese medicine composition same recipe of head disease is made any Chinese medicine preparation and is also fallen within the scope and spirit of the invention, As long as i.e. composition of raw materials and identical medicine of the present invention just fall within the scope and spirit of the invention.

Claims (7)

1. a kind of Chinese medicine composition of preventing and treating Rana grylia torticollis disease is it is characterised in that crude drug by following masses part proportioning Make：Radix Et Rhizoma Rhei 170-210 part, Concha Haliotidis 50-80 part, toothed burclover 190-220 part, Radix Astragali 180-215 part, Myrrha 180-210 part, Chinese mugwort Careless 80-110 part, Herba Salviae Chinensiss 130-165 part, Fructus Gardeniae 185-215 part, Herba Asari 105-135 part, Fructus Aurantii 210-245 part, Fructus Gleditsiae Abnormalis 105- 140 parts, Radix Paeoniae Alba 135-160 part, Herba Paederiae 120-150 part.

2. according to claim 1 preventing and treating Rana grylia torticollis disease Chinese medicine composition it is characterised in that：Radix Et Rhizoma Rhei 170- 205 parts, Concha Haliotidis 50-75 part, toothed burclover 190-215 part, Radix Astragali 190-215 part, Myrrha 185-210 part, Folium Artemisiae Argyi 80-105 part, purple Ginseng 130-160 part, Fructus Gardeniae 185-210 part, Herba Asari 105-130 part, Fructus Aurantii 210-240 part, Fructus Gleditsiae Abnormalis 110-140 part, Radix Paeoniae Alba 140- 160 parts, Herba Paederiae 125-150 part.

3. according to claim 1 preventing and treating Rana grylia torticollis disease Chinese medicine composition it is characterised in that：Radix Et Rhizoma Rhei 180- 205 parts, Concha Haliotidis 50-70 part, toothed burclover 190-210 part, Radix Astragali 190-210 part, Myrrha 190-210 part, Folium Artemisiae Argyi 90-105 part, purple Ginseng 140-160 part, Fructus Gardeniae 190-210 part, Herba Asari 110-130 part, Fructus Aurantii 220-240 part, Fructus Gleditsiae Abnormalis 120-140 part, Radix Paeoniae Alba 145- 160 parts, Herba Paederiae 130-150 part.

4. according to claim 1 preventing and treating Rana grylia torticollis disease Chinese medicine composition it is characterised in that：Radix Et Rhizoma Rhei 190- 205 parts, Concha Haliotidis 55-70 part, toothed burclover 190-205 part, Radix Astragali 195-210 part, Myrrha 190-205 part, Folium Artemisiae Argyi 95-105 part, purple Ginseng 140-155 part, Fructus Gardeniae 190-205 part, Herba Asari 110-125 part, Fructus Aurantii 220-235 part, Fructus Gleditsiae Abnormalis 120-135 part, Radix Paeoniae Alba 145- 155 parts, Herba Paederiae 135-150 part.

5. according to claim 1 preventing and treating Rana grylia torticollis disease Chinese medicine composition it is characterised in that:Radix Et Rhizoma Rhei 190- 200 parts, Concha Haliotidis 60-70 part, toothed burclover 190-200 part, Radix Astragali 200-210 part, Myrrha 190-200 part, Folium Artemisiae Argyi 100-105 part, Herba Salviae Chinensiss 150-155 part, Fructus Gardeniae 200-205 part, Herba Asari 110-120 part, Fructus Aurantii 220-230 part, Fructus Gleditsiae Abnormalis 130-135 part, the Radix Paeoniae Alba 145-150 part, Herba Paederiae 140-150 part.

6. according to claim 1 preventing and treating Rana grylia torticollis disease Chinese medicine composition it is characterised in that:200 parts of Radix Et Rhizoma Rhei, 60 parts of Concha Haliotidis, 200 parts of toothed burclover, 200 parts of the Radix Astragali, 200 parts of Myrrha, 100 parts of Folium Artemisiae Argyi, 150 parts of Herba Salviae Chinensiss, 200 parts of Fructus Gardeniae, Herba Asari 120 parts, 230 parts of Fructus Aurantii, 130 parts of Fructus Gleditsiae Abnormalis, 150 parts of the Radix Paeoniae Alba, 140 parts of Herba Paederiae.

7. prevent and treat the preparation method of the Chinese medicine composition of Rana grylia torticollis disease according to claim 1 it is characterised in that wrapping Include following steps:

The first step:Calculate the raw material weight of batch production by formula proportion；

Second step:The raw material calculating batch production is positioned in stirring container, be soaked in water 3-5 hour, wherein the use of water Measure 30 times for Chinese medicine gross weight, warm fire heats burning to seething with excitement, and endures 15-20 minute, then after insulation 3 hours, then warm fire is heated burning To seething with excitement, endure 25-30 minute；

3rd step:Carry out centrifugal filtration, filtrate through 2-3 hour precipitation after, second centrifugal filtration；Filtrate is treats The medicine of Rana grylia torticollis disease.