CN106472547B - A kind of composition pesticide containing chlorobenzene ether amide and Prochloraz - Google Patents
A kind of composition pesticide containing chlorobenzene ether amide and Prochloraz Download PDFInfo
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- CN106472547B CN106472547B CN201610881041.5A CN201610881041A CN106472547B CN 106472547 B CN106472547 B CN 106472547B CN 201610881041 A CN201610881041 A CN 201610881041A CN 106472547 B CN106472547 B CN 106472547B
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- prochloraz
- ether amide
- chlorobenzene ether
- composition pesticide
- chlorobenzene
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
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- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to one kind to contain composition pesticide and its application, and effective component is chlorobenzene ether amide, Prochloraz, and the weight fraction ratio of chlorobenzene ether amide and Prochloraz is 20: 1~1: 20.Two kinds of effective component compound synergic effects of the present invention are significant, have excellent control efficiency to the various fungal diseases on the crops such as fruits and vegetables and cereal crops；The present invention not only increases the control efficiency to gray mold, controls effect with preferably simultaneous to diseases such as anthracnose, leaf spots, expands fungicidal spectrum, also reduce Pesticide use amount, reduce residual quantity of the pesticide on crops, alleviate the pollution to environment, delays the generation of disease drug resistance.
Description
Technical field
The present invention is a kind of agricultural bacteriocide, in particular to a kind of using chlorobenzene ether amide and Prochloraz as the agriculture of effective component
Drug composition, for preventing and treating fruits and vegetables gray mold.
Background technique
Chlorobenzene ether amide is Formulas I disclosed in CN104557709A, chemical name: N- (2- (2,4- dichlorophenoxy) benzene
Base -3- (difluoromethyl) -1- methyl-1 H- pyrazoles -4- amide, molecular formula: C18H13Cl2F2N3O2, structural formula are as follows:
Chlorobenzene ether amide acts on pathogen succinate dehydrogenase (SDHI) and inhibits its respiration, and effect is special, medicine
Strong, persistent, obvious effect of increasing production are imitated, the gray mold common to cucumber, tomato, strawberry has extraordinary effect.
Prochloraz (prochloraz) chemical name: N- propyl-N- [2- (2,4,6- Trichlorophenoxy) ethyl] -1H- miaow
Azoles -1- formamide, molecular formula: C15H16Cl3N3O2, this product are efficient, wide spectrum, low-toxicity fungicide, are controlled with prevention & protection
The multiple actions such as treatment, including Prochloraz is imidazoles.It is conventional to use prevention and treatment gourd, fruit and vegetable anthracnose, leaf spot, it can also prevent harnessing the river
Rice rice blast, bakanae disease of rice, rape anthracnose and sclerotiniose.
It is serious and relatively conventional that the pathogen of Botrytis cinerea (Botrytis cinerea) causes gray mold to endanger fruits and vegetables.Common
There are gray mold of cucumber, graw mold of tomato, grey mould fruit rot of strawberry etc..The disease optimum onset temperature is 20 DEG C -25 DEG C, fruits and vegetables florescence
It is easy to happen, is mostly infected since flower, endanger fruit.
In agricultural production, the scientifical use pesticide due to long-term continuous administration single variety fungicide or not, leads to disease
Drug resistance get worse；Simultaneously as excessive result in environmental pollution and the increase of peasant's drug cost etc. using pesticide
Problem is unfavorable for the sustainable development of agricultural.Therefore, the compound drug for developing efficient, low toxicity, low-residual, not only facilitates and prolongs
The drug resistance of slow disease, but also dosage can be reduced, save the cost reduces the pollution to environment.
Inventor has made intensive studies the compounded formula screening of chlorobenzene ether amide and Prochloraz, finds chlorobenzene ether amide
It is compounded with Prochloraz, within the scope of certain compound proportion, is had significant synergies to prevention and treatment fruits and vegetables gray mold,
In actual use, there is preferable control efficiency to gray mold of cucumber, grey mould fruit rot of strawberry, Botrytis cinerea etc., pass through
Further research, completes the present invention.
Summary of the invention
The purpose of the present invention is to provide one kind efficiently, low toxicity and lasting period are long, can reduce dosage in use, drop
The generation of low disease drug resistance is conducive to the composition pesticide of gray mold comprehensive treatment.
The technical solution that the present invention realizes that purpose uses is: a kind of pesticide combination containing chlorobenzene ether amide and Prochloraz
Object, effective component are chlorobenzene ether amide and Prochloraz, and the weight fraction ratio of chlorobenzene ether amide and Prochloraz is 20: 1~1: 20,
Chlorobenzene ether amide and weight percent of the Prochloraz weight summation in composition pesticide are 5%~80%, remaining is in pesticide
Allow using with acceptable auxiliary element.
Composition pesticide of the present invention is prepared into any one dosage form used in suitable agricultural production by known method, than
Preferable dosage form has aqueous emulsion, wettable powder, water dispersible granules or missible oil etc..
Auxiliary component used in the present composition includes solvent, emulsifier, wetting agent, disintegrating agent, stabilizer, dispersion
Agent, defoaming agent, antifreezing agent, cosolvent, carrier etc. be beneficial to effective component it is stable in the formulation and play drug effect known substance,
It is all that various composition commonly used or allowed to use in pesticidal preparations, specific ingredient and dosage are true by test according to recipe requirements
It is fixed.
Chlorobenzene ether amide is compounded with Prochloraz, to gray mold, is had within the scope of certain compound proportion significant
Synergistic effect, in actual use, the diseases such as gray mold of cucumber, graw mold of tomato, Botrytis cinerea, grey mould fruit rot of strawberry are equal
There is preferable control efficiency.
The frequency of administration and amount of application of the present composition change with crops, disease, weather condition and have small variations,
It can achieve the purpose that effectively prevent by using dosage appropriate.
Compared with the prior art, the advantages of the present invention are as follows.
1, chlorobenzene ether amide is compounded with Prochloraz has significant synergistic effect, has to the fruits and vegetables gray mold such as cucumber, tomato
Higher prevention and treatment activity.
2, chlorobenzene ether amide is different from the Prochloraz mechanism of action, expands fungicidal spectrum, can delay the generation of disease drug resistance.
3, two kinds of effective component compoundings of chlorobenzene ether amide and Prochloraz, reduce Pesticide use amount, reduce pesticide and making
Residual on object reduces the pollution to environment.
Specific embodiment
To better understand the essence of the present invention, below with reference to embodiment, the content of the present invention will be further explained,
But limitation of the present invention cannot be considered as.
(1) dosage form and formulation Example.
Effective constituents A uses 95% chlorobenzene ether amide raw medicine in following examples, and effective component B uses 97% Prochloraz
Raw medicine, each component percentage composition are weight percentage.
1 30% chlorobenzene ether amide Prochloraz suspending agent of embodiment
Chlorobenzene ether amide 15%, Prochloraz 15%, alkyl phenol polyoxyethylene ether 3-5%, sodium lignin sulfonate 1-1.5%,
Ethylene glycol 3-5%, defoaming agent 0.5-1%, aluminium-magnesium silicate 3-5%, deionized water add to 100%.
2 45% chlorobenzene ether amide prochloraz aqueous emulsion of embodiment
Chlorobenzene ether amide 20%, Prochloraz 25%, calcium dodecyl benzene sulfonate 2-3%, phenethyl phenol polyethenoxy ether 2-
3%, phosphoric acid ester polyoxyethylene ether 2-3%, ethylene glycol 3-5%, defoaming agent 0.5-1%, aluminium-magnesium silicate 2-3%, solvent naphtha 10-
12%, deionized water complements to 100%.
3 45% chlorobenzene ether amide Prochloraz wettable powder of embodiment
Chlorobenzene ether amide 15%, Prochloraz 30%, lauryl sodium sulfate 2-3%, alkylnaphthalene sulfonate 2-3%, hard charcoal
Black 30%, kaolin complements to 100%.
4 40% chlorobenzene ether amide Prochloraz water dispersible granules of embodiment
Chlorobenzene ether amide 25%, Prochloraz 15%, lauryl sodium sulfate 2-3%, alkylnaphthalene sulfonate 3-4%, poly- carboxylic
Hydrochlorate 4-6%, white carbon black 12-15%, kaolin complement to 100%.
5 30% chlorobenzene ether amide Prochloraz missible oil of embodiment
Chlorobenzene ether amide 25%, Prochloraz 5%, calcium dodecyl benzene sulfonate 1-2%, phenethyl phenol polyethenoxy ether 2-
3%, alkyl phenol formaldehyde resin polyoxyethylene ether 2-3%, solvent naphtha complements to 100%.
(2) indoor biological activity assay of the present composition and field efficacy verifying.
1, the indoor joint toxicity measuring of chlorobenzene ether amide and Prochloraz and its complex composition to gray mold of cucumber.
The test method of indoor biometrics: reference standard NY/T1156.6-2006, using growth rate method measurement medicament to Huang
The inhibiting effect of melon grey mold pathogen mycelia growth.On the basis of preliminary experiment, from each medicament to germ mycelia growth inhibition
Rate is up to 5 concentration of design in 10%~90% range, first by 95% chlorobenzene ether amide raw medicine and 97% Prochloraz raw medicine with acetone
The medical fluid for being made into series of concentrations for solvent is spare, is then added to medical fluid in 1% ratio and has melted and be cooled to 35 DEG C or so
PDA culture medium in, after sufficiently shaking up, pour into the culture dish (diameter 90mm) of sterilizing be made band medicine plate, it is every processing four times
It repeats, the processing of sterile water is added as blank control；With punch (diameter 5mm) picking botrytis cinerea pers bacterium of sterilizing
Cake, the face-down aseptic inoculation of mycelia are inverted in culture in 25 DEG C of constant incubator, adopt after cultivating 5d in the center with medicine plate
Colony diameter is measured with crossing method, calculates each medicament to the EC of pathogen50, and calculate virulence according to the following equation and refer to
Number, compares the virulence and bacteriostasis of different agents.
It is for statistical analysis with DPS statistical analysis software, calculate the EC of each medicament50, and mixture is calculated according to Sun Yunpei's Method
Co-toxicity coefficient (CTC value).
Survey toxicity index (ATI)=(standard agent EC50/ reagent agent EC50)×100。
Percentage composition+B the medicament toxicity index of A in theoretical toxicity index (TTI)=A medicament toxicity index × mixture × mixed
The percentage composition of B in agent.
Co-toxicity coefficient (CTC)=[mixture surveys toxicity index (ATI)/mixtures theoretical toxicity index (TTI)] × 100.
Act on the criteria for classifying according to NY/T11547.7-2006 insecticide combination: co-toxicity coefficient (CTC) >=120 shows as increasing
Effect effect；Co-toxicity coefficient (CTC)≤80 shows as antagonism；80 < co-toxicity coefficient (CTC) < 120 shows as summation action.
The indoor joint toxicity measuring of table 1, chlorobenzene ether amide and Prochloraz and its complex composition to gray mold of cucumber
As it can be seen from table 1 chlorobenzene ether amide and Prochloraz are used in compounding in 20: 1-1: 20 (by weight) ranges
When, coefficient (CTC) is spent together greater than 120, shows that it acts synergistically to the prevention and treatment of gray mold of cucumber with synergy, especially 10
: in 1-1: 5 ranges, synergistic effect is the most obvious, spends coefficient (CTC) together greater than 140, it is seen that chlorobenzene ether amide and Prochloraz
There are reasonability and feasibility for compounding.
2, chlorobenzene ether amide and Prochloraz and its effect test of built composition for preventing and controlling cucumber field medicine gray mold
Selection above example 1~5 carry out prevention and treatment gray mold of cucumber field trial, by with chlorobenzene ether amide and Prochloraz
The Contrast on effect of single dose, the synergistic effect after verifying compounding, 50% Boscalid WG are compareed.Test site is Shandong Shouguang vegetable
Dish greenhouse base, time are on December 13rd, 2015, test three repetitions of each processing, cell random alignment, each cell face
Product is 30m2, using back-pack electric compression sprayer, application same day fine day, the cucumber of all cells is all in fruiting of blooming
Phase, 10 DEG C~28 DEG C of temperature, are suitable for gray mold during test.
Investigation method every 2-3 plants of investigation, is investigated referring to GB/T 17980.28-2000, every cell using 5 points of samplings
Every plant of whole fruits, and disease index is calculated according to following stage division.
0 grade: disease-free spot；
1 grade: residual flower morbidity；
3 grades: the morbidity of areola portion；
5 grades: scab length accounts for 10% or less fruit；
7 grades: scab length accounts for the 11%-25% of fruit；
9 grades: scab length accounts for 26% of fruit or more.
It carries out second within 7 days after being administered for the first time to be administered, be investigated within 7 days after being administered within 7 days and second after being administered for the first time respectively.
Calculation formula is as follows:
Disease index=[Σ (the number of sick fruits at different levels × opposite value of series)/(investigation the total number of fruits × highest level number)] × 100
Control efficiency %=(1-CK0 × Pt1/CK1 × Pt0) × 100
Wherein: CK0 represents disease index before blank district is administered；CK1 represents disease index after blank district application；
Pt0 represents disease index before chemicals treatment district is administered；Pt1 represents disease index after chemicals treatment district application.
Table 2, chlorobenzene ether amide and Prochloraz built composition for preventing and controlling gray mold of cucumber field control effectiveness test
Above-mentioned data are analyzed to obtain, chlorobenzene ether amide and Prochloraz compounding after, after medicine 7 days preventive effects more than 70%, and
Chlorobenzene ether amide single dose 7 days preventive effects after medicine for the first time are 58.30%, and the preventive effect of Prochloraz single dose is 41.91%, it is seen that two kinds have
There is good synergistic effect after imitating ingredient compounding.And 7 days after secondary medicine, preventive effect of all compound preparations to gray mold of cucumber
It has been more than 80%, it is seen that preparation extends the lasting period that gray mold of cucumber is prevented and treated after compounding, and control efficiency is more longlasting.
Claims (5)
1. a kind of composition pesticide containing chlorobenzene ether amide and Prochloraz, it is characterised in that: effective component is chlorobenzene ether amide
And Prochloraz, the two weight fraction ratio are 10: 1~1: 5.
2. a kind of composition pesticide containing chlorobenzene ether amide and Prochloraz according to claim 1, it is characterised in that: institute
The weight for stating chlorobenzene ether amide and Prochloraz accounts for the 5%~80% of total weight, remaining is the auxiliary agent allowed on pesticide.
3. a kind of composition pesticide containing chlorobenzene ether amide and Prochloraz according to claim 1, which is characterized in that institute
It states composition pesticide and is configured to any one dosage form using chlorobenzene ether amide and Prochloraz as active constituent and auxiliary agent.
4. a kind of composition pesticide containing chlorobenzene ether amide and Prochloraz according to claim 3, it is characterised in that: institute
Stating dosage form is suspending agent, aqueous emulsion, wettable powder, water dispersible granules or missible oil.
5. the composition pesticide of chlorobenzene ether amide and Prochloraz according to claim 1, it is characterised in that: be applied to fruits and vegetables
Upper prevention and treatment gray mold.
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| CN201610881041.5A CN106472547B (en) | 2016-10-09 | 2016-10-09 | A kind of composition pesticide containing chlorobenzene ether amide and Prochloraz |
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| CN102246791A (en) * | 2011-07-09 | 2011-11-23 | 海利尔药业集团股份有限公司 | Compounded pesticide sterilizing composition |
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| CN104206388A (en) * | 2013-05-30 | 2014-12-17 | 陕西美邦农药有限公司 | Pesticide composition containing penflufen |
| CN104719328A (en) * | 2013-12-20 | 2015-06-24 | 陕西美邦农药有限公司 | Sedaxane-containing pesticide composition |
| CN105557729A (en) * | 2014-10-14 | 2016-05-11 | 陕西美邦农药有限公司 | Sterilization composition containing benzovindiflupyr |
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- 2016-10-09 CN CN201610881041.5A patent/CN106472547B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102246791A (en) * | 2011-07-09 | 2011-11-23 | 海利尔药业集团股份有限公司 | Compounded pesticide sterilizing composition |
| CN103385250A (en) * | 2012-05-09 | 2013-11-13 | 陕西韦尔奇作物保护有限公司 | Bactericidal composition containing fluxapyroxad |
| CN104206388A (en) * | 2013-05-30 | 2014-12-17 | 陕西美邦农药有限公司 | Pesticide composition containing penflufen |
| CN104719328A (en) * | 2013-12-20 | 2015-06-24 | 陕西美邦农药有限公司 | Sedaxane-containing pesticide composition |
| CN105557729A (en) * | 2014-10-14 | 2016-05-11 | 陕西美邦农药有限公司 | Sterilization composition containing benzovindiflupyr |
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