CN106421534A - Traditional Chinese medicinal composition for treating rheumatoid arthritis and preparation method thereof - Google Patents

Traditional Chinese medicinal composition for treating rheumatoid arthritis and preparation method thereof Download PDF

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CN106421534A
CN106421534A CN201611099796.6A CN201611099796A CN106421534A CN 106421534 A CN106421534 A CN 106421534A CN 201611099796 A CN201611099796 A CN 201611099796A CN 106421534 A CN106421534 A CN 106421534A
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parts
caulis
radix
herba
rhizoma
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郭文英
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Abstract

The invention discloses a traditional Chinese medicinal composition for treating rheumatoid arthritis and a preparation method thereof. The traditional Chinese medicinal composition comprises, by weight, the rootbark of Chinese hydrangeavine, celastrus aculeatus, monkshoodvine root-bark, ormosia henryi prain, rubus quinquefoliolatus, roots or stems of diversifolious creepers, allgrass of Chinese alangium, radix alangii, Tonkin pepper herbs, caulis phyllanthi reticulati, pterospermi heterophylli, artemisia sieversiana, Chinese juniper, rhododendron lutescens franch, sphallerocarpus gracilis, hollyhock, tamarisk chinensis, trona, parabarium micranthum, lycopodium clavatum, clerodendrum bungei, cortex acanthopanacis, Chinese fevervine herbs and roots, rhizoma acori graminei, stems of champion bauhinia, philippine flemingia roots, herba lycopodii complanati, gaultheria forrestii diels, campanumoea javanica, Chinese yams, medicated leaven, caulis spatholobi, kadsura pepper stems, cassia twigs, licorice roots, horse bones, eagle bones, rhizoma atractylodis macrocephalae, coix seeds, poria cocos and dried tangerine or orange peels. The traditional Chinese medicinal composition has the effect of promoting blood circulation, removing stasis, dredging collaterals and relieving pain, supports the healthy energy and inhibits toxic and side effects of some drugs, and accordingly, both root causes and symptoms are treated.

Description

A kind of treat Chinese medicine composition of rheumatoid arthritiss and preparation method thereof
Technical field
A kind of the present invention relates to pharmaceutical technology field, more particularly, it relates to Chinese medicine group for treating rheumatoid arthritiss Compound and preparation method thereof.
Background technology
American society of rheumatism in 1987 define rheumatoid arthritiss (rheumatoid arthritis, RA) be with tired And the autoimmune disease that the multisystem based on periarticular is struvite, invading the Minor articulus such as handss, foot, wrist primary disease, if not more Treat in time, the state of an illness gradually increases, can finally cause joint deformity, tetanic and function to lose, cause different degrees of deformity, sternly Health and the life quality of patient are endangered again.RA all has morbidity all over the world, and the northern area of China is the district occurred frequently of primary disease.
Western medicine explain RA may with the difference of endocrine, metabolism, nutrition, geography, occupation, psychology and social environment, The aspect such as antibacterial and virus infection and inherited genetic factorss has relation.Traditional Chinese medical science argument thinks to cause body because of pathogens such as wind, cold, wet, heat Interior " blood is logical not bitterly, blood stagnation of QI and blood may bring about pain ".Therefore " blood is obstructed " is this sick main cause.
But the untoward reaction such as gastrointestinal side effect that most of Western medicine are likely to occur, severe patient have digestive tract ulcer, Bleeding, perforation etc., a lot of these problems of patient Chang Yin are had to stopped treatment, directly affects curative effect.This causes patient to carry on a shoulder pole again Heart adverse effect or lack confidence to medicine practical function effect, so as to increase the psychological burden of patient again, reduces Difficulty is brought from doctor to clinical treatment.Therefore the light medicine of exploitation small toxicity and untoward reaction is asking for a urgent need solution Topic.
Content of the invention
The technical problem to be solved in the present invention is, for the drawbacks described above of prior art, provides one kind and treats rheumatoid Property arthritic Chinese medicine composition and preparation method thereof, be mainly used in treating rheumatoid arthritiss, with blood circulation promoting and blood stasis dispelling, dredging collateral Analgesic efficacy, goes back strengthening the body resistance, suppresses the toxic and side effects of some drugses, so as to reach the purpose for the treatment of both the principal and secondary aspects of a disease.
The technical solution adopted for the present invention to solve the technical problems is：A kind for the treatment of in rheumatoid arthritiss is provided Drug composition, is prepared from by the component of following weight portion：Cortex schizophragmatis integrifolii radiciss 0.2-5 part, Celastrus aceleatus Merr 0.2-5 part, Cortex Ampelopsis Aconitifoliae Radiciss 0.2-5 Part, 0rmosia henryi Prain 0.2-5 part, Herba Rubi blinii 0.2-5 part, Radix Parthenocissi Heterophyllae 0.2-5 part, Radix Alangii 0.2-5 part, Herba Piperris Tonkinensiss 0.2-5 part, snapper Eye 0.2-5 part, Pterospermi Heterophylli 0.2-5 part, Artemisia sieversiana Willd. 0.2-5 part, Juniperus oxycedruss 0.2-5 part, Hemerocallis citrina Baroni Cuculus polioephalus 0.2-5 part, Sphallerocarpus gracilis 0.2-5 Part, Althaea rosea (L.) Cavan. 0.2-5 part, Cacumen Tamariciss 0.2-5 part, Tronae 0.2-5 part, eucommia vine 0.2-5 part, Herba Lycopodii 0.2-5 part, Caulis et folium clerodendri bungei 0.2-5 part, five as skin 0.2-5 part, Herba Paederiae 0.2-5 part, Rhizoma Acori Graminei 0.2-5 part, Caulis Bauhihiae Championii 0.2-5 part, Radix Flemingiae Philippinensiss 0.2-5 Part, Caulis Entadae 0.2-5 part, Radix seu Folium Gaultheriae Forrestii 0.2-5 part, leopard 0.2-5 part, Rhizoma Dioscoreae 0.2-5 part, Massa Medicata Fermentata 0.2-5 part, Caulis Spatholobi 0.2-5 part, Caulis Piperis Kadsurae 0.2-5 part, Ramulus Cinnamomi 0.2-5 part, Radix Glycyrrhizae 0.2-5 part, Os Equi 5-7 part, bear bone 5-7 part, Rhizoma Atractylodis Macrocephalae 2-6 part, Semen Coiciss 2-6 part, Poria 2-6 part, Pericarpium Citri Reticulatae 2-6 part.
Preferably, the Chinese medicine composition of described treatment rheumatoid arthritiss, by the component preparation of following weight portion Become：Cortex schizophragmatis integrifolii radiciss 1.6-3 part, Celastrus aceleatus Merr 1.6-3 part, Cortex Ampelopsis Aconitifoliae Radiciss 1.6-3 part, 0rmosia henryi Prain 1.6-3 part, Herba Rubi blinii 1.6-3 part, triangle Wind 1.6-3 part, Radix Alangii 1.6-3 part, Herba Piperris Tonkinensiss 1.6-3 part, snapper eye 1.6-3 part, Pterospermi Heterophylli 1.6-3 part, Artemisia sieversiana Willd. 1.6-3 Part, Juniperus oxycedruss 1.6-3 part, Hemerocallis citrina Baroni Cuculus polioephalus 1.6-3 part, Sphallerocarpus gracilis 1.6-3 part, Althaea rosea (L.) Cavan. 1.6-3 part, Cacumen Tamariciss 1.6-3 part, Tronae 1.6-3 part, eucommia vine 1.6-3 part, Herba Lycopodii 1.6-3 part, Caulis et folium clerodendri bungei 1.6-3 part, five as skin 1.6-3 part, Herba Paederiae 1.6-3 Part, Rhizoma Acori Graminei 1.6-3 part, Caulis Bauhihiae Championii 1.6-3 part, Radix Flemingiae Philippinensiss 1.6-3 part, Caulis Entadae 1.6-3 part, Radix seu Folium Gaultheriae Forrestii 1.6-3 part, money Leopard 1.6-3 part, Rhizoma Dioscoreae 1.6-3 part, Massa Medicata Fermentata 1.6-3 part, Caulis Spatholobi 1.6-3 part, Caulis Piperis Kadsurae 1.6-3 part, Ramulus Cinnamomi 1.6-3 part, sweet Careless 1.6-3 part, Os Equi 5.6-6.3 part, breast bone 5.6-6.3 part, Rhizoma Atractylodis Macrocephalae 3.5-4.5 part, Semen Coiciss 3.5-4.5 part, Poria 3.5- 4.5 parts, Pericarpium Citri Reticulatae 3.5-4.5 part.
Preferably, the Chinese medicine composition of described treatment rheumatoid arthritiss, by the component preparation of following weight portion Become：3 parts of Cortex schizophragmatis integrifolii radiciss, 1.3 parts of Celastrus aceleatus Merr, 1.8 parts of Cortex Ampelopsis Aconitifoliae Radiciss, 2.1 parts of 0rmosia henryi Prain, 1.2 parts of Herba Rubi blinii, 0.5 part of Radix Parthenocissi Heterophyllae, anise 0.25 part of maple, 0.2 part of Herba Piperris Tonkinensiss, 0.8 part of snapper eye, 2.2 parts of Pterospermi Heterophylli, 4.5 parts of Artemisia sieversiana Willd., 2.6 parts of Juniperus oxycedruss, Hemerocallis citrina Baroni Cuculus polioephalus 0.8 part, 0.4 part of Sphallerocarpus gracilis, 0.2 part of Althaea rosea (L.) Cavan., 1.7 parts of Cacumen Tamariciss, 0.8 part of Tronae, 0.5 part of eucommia vine, 1.5 parts of Herba Lycopodii, smelly 1.2 parts of Paeonia suffruticosa, five as 1.8 parts of skin, 3.5 parts of Herba Paederiae, 0.6 part of Rhizoma Acori Graminei, 1.25 parts of Caulis Bauhihiae Championii, 1.3 parts of Radix Flemingiae Philippinensiss, Caulis Entadae 0.25 part, 5 parts of Radix seu Folium Gaultheriae Forrestii, 3.5 parts of leopard, 3.5 parts of Rhizoma Dioscoreae, 4.8 parts of Massa Medicata Fermentata, 1.3 parts of Caulis Spatholobi, 1.9 parts of Caulis Piperis Kadsurae, Ramulus Cinnamomi 0.2 part, 4.8 parts of Radix Glycyrrhizae, 6 parts of Os Equi, bear 6 parts of bone, 4.5 parts of the Rhizoma Atractylodis Macrocephalae, 3.4 parts of Semen Coiciss, 4 parts of Poria, 3.8 parts of Pericarpium Citri Reticulatae.
The present invention also provides a kind of preparation method of the Chinese medicine composition for the treatment of rheumatoid arthritiss as above, bag Include following steps：
（1）The Cortex schizophragmatis integrifolii radiciss of formula ratio are taken, is crushed to 50-100 mesh, add 8 times amount distilled water, heated and boiled 1-3 hour, let cool, Centrifuge 750-900r/min is centrifuged 5-8min, filtration, filtering residue heated and boiled 0.5-1 hour again, centrifuge 750-900r/ Min is centrifuged 3-6min, filtration, and filtering residue adds 4-6 times amount concentration for the ethanol of 70-85%, reflux, extract, 2-4 hour, centrifuge 450-700 r/min is centrifuged 5-8min, filters, 2-3 time repeatedly, merges all of above filtrate, and decompression recycling ethanol, through thin film steaming Sending out the liquid for relative density being concentrated into for 0.75-0.98, obtains Cortex schizophragmatis integrifolii radiciss extracting solution, stand-by；
（2）Take respectively the Celastrus aceleatus Merr of formula ratio, Cortex Ampelopsis Aconitifoliae Radiciss, 0rmosia henryi Prain, Herba Rubi blinii, Radix Parthenocissi Heterophyllae, Radix Alangii, Herba Piperris Tonkinensiss, snapper eye, Pterospermi Heterophylli, Artemisia sieversiana Willd., Juniperus oxycedruss, Hemerocallis citrina Baroni Cuculus polioephalus, Sphallerocarpus gracilis, Althaea rosea (L.) Cavan., Cacumen Tamariciss, Tronae, eucommia vine, Herba Lycopodii, Caulis et folium clerodendri bungei, five such as Skin, Herba Paederiae, Rhizoma Acori Graminei, Caulis Bauhihiae Championii, Radix Flemingiae Philippinensiss, Caulis Entadae, Radix seu Folium Gaultheriae Forrestii, leopard, Rhizoma Dioscoreae, Massa Medicata Fermentata, Caulis Spatholobi, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Radix Glycyrrhizae, respectively according to step（1）Extracting method, obtain the extracting solution of each raw material, stand-by；
（3）Take the Os Equi of formula ratio respectively, bear bone to chop block, add distilled water that 8-10 hour is boiled, bone juice is obtained, stand-by；
（4）Take the Rhizoma Atractylodis Macrocephalae of formula ratio, Semen Coiciss, Poria, Pericarpium Citri Reticulatae respectively, after drying, be crushed to micropowder respectively, then mix equal Even, obtain mixed powder；
（5）By step（1）-（3）The extracting solution for obtaining, bone juice mix, and are slowly at the uniform velocity stirred with stirring paddle, stir 40-45min After become oar material, a small amount of into slurry repeatedly add step（4）Mixed powder, continue stirring, until mix homogeneously, make ball Grain.
Preferably, the preparation method of the Chinese medicine composition of described treatment rheumatoid arthritiss, the Rhizoma Atractylodis Macrocephalae, Semen Coiciss Core, Poria, Pericarpium Citri Reticulatae are all ground into micropowder.
Preferably, the preparation method of the Chinese medicine composition of described treatment rheumatoid arthritiss, the Rhizoma Atractylodis Macrocephalae, Semen Coiciss Core, Poria, Pericarpium Citri Reticulatae mean diameter are all more than 300 mesh.
Implement Chinese medicine composition for the treatment of rheumatoid arthritiss of the present invention and preparation method thereof, with following beneficial effect Really：
The Chinese medicine composition of the present invention has functions that wind-damp dispelling, relaxing muscles and tendons to promote blood circulation, eliminating stasis to stop pain, bone and muscle strengthening, acute controlling The aspects such as lopsided, the tetanic symptom of outbreak symptom and the arthralgia that improves, local joint, have functions that unique；Additionally, logical The product from invigorating the spleen to clear away damp pathogen such as the Rhizoma Atractylodis Macrocephalae, Semen Coiciss, Poria, Pericarpium Citri Reticulataes are crossed, this compositions can also improve patient's gastrointestinal function, very big Avoid and inhibit the toxic and side effects of some drugses in degree, make medicine play maximum curative effect；It can be seen that, the present invention is treated The Chinese medicine composition of rheumatoid arthritiss has blood circulation promoting and blood stasis dispelling, outside removing obstruction in the collateral to relieve pain effect, goes back strengthening the body resistance, suppresses some drugses Toxic and side effects, so as to reach the purpose for the treatment of both the principal and secondary aspects of a disease.
The Rhizoma Atractylodis Macrocephalae of the present invention, Semen Coiciss, Poria, the fully absorbing using the more favourable Chinese medicine of ultrastructurepower technology of Pericarpium Citri Reticulatae, enter And shorten medicine using the course for the treatment of and reduce dosage, curative effect of medication is improve, reduces medicine of the medicine in food animal The risk that thing residual etc. is brought.
Specific embodiment
Below, in conjunction with specific embodiment, the present invention is described further：
In the present invention, if not refering in particular to, all of part, percentage ratio are unit of weight, the equipment for being adopted and raw material etc. Buy from market or commonly used in the art.Method in following embodiments, if no special instructions, is the routine side of this area Method.
The Chinese medicine composition of present invention treatment rheumatoid arthritiss, is prepared from by the component of following weight portion：Bore ground Wind 0.2-5 part, Celastrus aceleatus Merr 0.2-5 part, Cortex Ampelopsis Aconitifoliae Radiciss 0.2-5 part, 0rmosia henryi Prain 0.2-5 part, Herba Rubi blinii 0.2-5 part, Radix Parthenocissi Heterophyllae 0.2-5 Part, Radix Alangii 0.2-5 part, Herba Piperris Tonkinensiss 0.2-5 part, snapper eye 0.2-5 part, Pterospermi Heterophylli 0.2-5 part, Artemisia sieversiana Willd. 0.2-5 part, Juniperus oxycedruss 0.2-5 part, Hemerocallis citrina Baroni Cuculus polioephalus 0.2-5 part, Sphallerocarpus gracilis 0.2-5 part, Althaea rosea (L.) Cavan. 0.2-5 part, Cacumen Tamariciss 0.2-5 part, Tronae 0.2-5 part, Eucommia vine 0.2-5 part, Herba Lycopodii 0.2-5 part, Caulis et folium clerodendri bungei 0.2-5 part, five as skin 0.2-5 part, Herba Paederiae 0.2-5 part, Rhizoma Acori Graminei 0.2-5 part, Caulis Bauhihiae Championii 0.2-5 part, Radix Flemingiae Philippinensiss 0.2-5 part, Caulis Entadae 0.2-5 part, Radix seu Folium Gaultheriae Forrestii 0.2-5 part, leopard 0.2-5 Part, Rhizoma Dioscoreae 0.2-5 part, Massa Medicata Fermentata 0.2-5 part, Caulis Spatholobi 0.2-5 part, Caulis Piperis Kadsurae 0.2-5 part, Ramulus Cinnamomi 0.2-5 part, Radix Glycyrrhizae 0.2-5 Part, Os Equi 5-7 part, breast bone 5-7 part, Rhizoma Atractylodis Macrocephalae 2-6 part, Semen Coiciss 2-6 part, Poria 2-6 part, Pericarpium Citri Reticulatae 2-6 part.
Its preparation method, comprises the steps：
（1）The Cortex schizophragmatis integrifolii radiciss of formula ratio are taken, is crushed to 50-100 mesh, add 8 times amount distilled water, heated and boiled 1-3 hour, let cool, Centrifuge 750-900r/min is centrifuged 5-8min, filtration, filtering residue heated and boiled 0.5-1 hour again, centrifuge 750-900r/ Min is centrifuged 3-6min, filtration, and filtering residue adds 4-6 times amount concentration for the ethanol of 70-85%, reflux, extract, 2-4 hour, centrifuge 450-700 r/min is centrifuged 5-8min, filters, 2-3 time repeatedly, merges all of above filtrate, and decompression recycling ethanol, through thin film steaming Sending out the liquid for relative density being concentrated into for 0.75-0.98, obtains Cortex schizophragmatis integrifolii radiciss extracting solution, stand-by；
（2）Take respectively the Celastrus aceleatus Merr of formula ratio, Cortex Ampelopsis Aconitifoliae Radiciss, 0rmosia henryi Prain, Herba Rubi blinii, Radix Parthenocissi Heterophyllae, Radix Alangii, Herba Piperris Tonkinensiss, snapper eye, Pterospermi Heterophylli, Artemisia sieversiana Willd., Juniperus oxycedruss, Hemerocallis citrina Baroni Cuculus polioephalus, Sphallerocarpus gracilis, Althaea rosea (L.) Cavan., Cacumen Tamariciss, Tronae, eucommia vine, Herba Lycopodii, Caulis et folium clerodendri bungei, five such as Skin, Herba Paederiae, Rhizoma Acori Graminei, Caulis Bauhihiae Championii, Radix Flemingiae Philippinensiss, Caulis Entadae, Radix seu Folium Gaultheriae Forrestii, leopard, Rhizoma Dioscoreae, Massa Medicata Fermentata, Caulis Spatholobi, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Radix Glycyrrhizae, respectively according to step（1）Extracting method, obtain the extracting solution of each raw material, stand-by；
（3）Take the Os Equi of formula ratio respectively, bear bone to chop block, add distilled water that 8-10 hour is boiled, bone juice is obtained, stand-by；
（4）Take the Rhizoma Atractylodis Macrocephalae of formula ratio, Semen Coiciss, Poria, Pericarpium Citri Reticulatae respectively, after drying, be crushed to micropowder respectively, then mix equal Even, obtain mixed powder；The Rhizoma Atractylodis Macrocephalae, Semen Coiciss, Poria, Pericarpium Citri Reticulatae are all ground into micropowder, mean diameter all 300 mesh with On.
（5）By step（1）-（3）The extracting solution for obtaining, bone juice mix, and are slowly at the uniform velocity stirred with stirring paddle, stir 40- Become oar material after 45min, a small amount of repeatedly addition step into slurry（4）Mixed powder, continue stirring, until mix homogeneously, system Become pill.
The pharmacologically active of each medicine of the present invention is as follows：
Cortex schizophragmatis integrifolii radiciss, are the root of saxifragaceae plant Cortex schizophragmatis integrifolii radiciss Schizophragma integrifolium (Franch.) Oliv. And ratan.The effect of with relaxing muscles and tendons and activating QI and blood in the collateral, expelling wind and activating blood circulation.It is usually used in rheumatic arthralgia, extremities joint is ached.
Celastrus aceleatus Merr, is the root of Celastraceae plant Celastrus aceleatus Merr Celastrus aculeatus Merr..With heat-clearing and toxic substances removing, The effect of expelling wind and removing dampness.It is usually used in rheumatic arthralgia, gout, nephritis, cholecystitis, leukemia.
Cortex Ampelopsis Aconitifoliae Radiciss, are the root bark of vitaceae head of the horse leaf Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae).With promoting blood circulation to remove blood stasis, eliminating inflammation and expelling toxin, granulation promoting long bone, The effect of eliminate wind and clear damp.Traumatic injury is controlled, fracture, furuncle swells and ache.
0rmosia henryi Prain, is pulse family Ormosia plant Lignum pterocarpi indici, is used as medicine with root, root bark, stem and leaf.With blood circulation promoting and blood stasis dispelling, dispel The effect of emaciation due to emotional upset swells.For traumatic injury, lumbar muscle strain, rheumatic arthritis, puerperal blood stasis pain, leucorrhea, mumps, Filaricide；Fracture is controlled in root bark external；Burn and scald is controlled in leaf external.
Herba Rubi blinii, is the herb of five leaf Fructus Rubi corchorifolii Immaturuss Rubus quinquefoliolatus Y ü et Lu of Rosaceae.Have The effect of promoting blood circulation to remove blood stasis.Cure mainly traumatic injury, curled paralysis, lumbago.
Radix Parthenocissi Heterophyllae, is vitaceae great Ye parthenocissuss Parthenocissus Heterophylla (Bl.) Merr. Root or stem.With the effect of expelling wind and removing dampness, removing toxic substances synthetism.It is usually used in rheumatic arthralgia, migraine, rheumatism sore, fracture.
Radix Alangii, is the root bark of Alangiaceae Radix Alangii Alangium chinense (Lour.) Harms.Remove with wind-dispelling The effect of wet, relaxing muscles and tendons and activating QI and blood in the collateral, eliminating stasis to stop pain, for rheumatic arthralgia, numb limbs and tense tendons, traumatic injury.
Herba Piperris Tonkinensiss, Piperaceae Piper plant optical axis ramie leaf Piperboehmeriaefolium Wall. var. Tonkinense C. DC., is used as medicine with root or Herb.The effect of with expelling wind and cold, eliminating stasis to stop pain.For catching a cold, rheumatism muscle Osteodynia, treating swelling and pain by traumatic injury, dysmenorrhea, amenorrhea, cold syndrome of the stomach pain.
Snapper eye, is euphorbia plant no hair Arillus Longan eyeball Phyllanthus reticulatus Poir. var. GlaberMuell.-Age. stem.With expelling wind and activating blood circulation, effect of dissipating blood stasis for subsidence of swelling；Cure mainly rheumatic arthritis pain, traumatic injury etc. Arthromyodynia.
Pterospermi Heterophylli, is root or the stem branch of Sterculiaceae plant pterospermum heterophyllum Hance.The effect of with wind-damp dispelling, relaxing muscles and tendons to promote blood circulation.With In rheumatic arthritis, rheumatoid arthritis, lumbar muscle strain, chronic lambago and skelalgia, hemiplegia, traumatic injury, bruise；External Control bleeding on knife.
Artemisia sieversiana Willd., is the herb of Compositae artemisia Artemisia sieversiana Willd. plant Artemisia sieversiana.With heat-clearing and toxic substances removing, The work(of anti-inflammatory analgetic.For carbuncle furunculosis, impetigo, skin eczema, cervical erosion.
Juniperus oxycedruss, are the leaf of Cupressaceae Juniperus oxycedruss Juniperus formosana Hayata.With heat-clearing and toxic substances removing, dampness removing to stop itchin it Effect.Cure mainly measles hyperpyrexia；Eczema；Tinea skin ulcer.
Hemerocallis citrina Baroni Cuculus polioephalus, are the rhizome of Ericaceae Hemerocallis citrina Baroni Cuculus polioephalus Rhododendron lutescens Franch..Have Tonifying the lung void, relieving cough and expelling phlegm, the effect that relievings asthma, for chronic tracheitiss.
Sphallerocarpus gracilis, are root and rhizome that Umbelliferae Sphallerocarpus gracilis belong to Sphallerocarpus gracilis plant Sphallerocarpus gracilis. There is renal cold of dispelling, effect of yellow fluid is held back, cures mainly menoxenia, sore waist and aching in the waist and the back in puerperal, gonorrhea, arthralgia, orchitiss.
Althaea rosea (L.) Cavan., is the root of Malvaceae Radix Malvae sylvestriss Althaea rosea (Linn.) Cavan..With heat clearing away, detoxify, evacuation of pus, The effect of diuresis.For enteritis, dysentery, urinary tract infection, urine swelling pain, cervicitis, leucorrhea.
Cacumen Tamariciss, are the delicate branch and leaf of Tamaricaceae Ramulus et Folium Tamariciss Tamarix chinensis Lour..Have and dissipate wind, solution The effect of table, rash.With controlling measles without adequate eruption, rheumatic arthralgia etc..
Tronae, be salt water lakeside generate a kind of master containing sodium carbonate branched crystallization, can be used for indigestion disease, gastric acid, Acid regurgitation, is hard and dry, placental retention, the disease such as amenorrhea.
Os Equi, is the skeleton of equine speciess horse Equus caballus orientalis Noack.With refreshment, detoxify Effect of sore.Cure mainly drowsiness, head sore, inflammation of external auditory meatus, ecthyma, the erosion of vulva, panaris.
Bear bone, be the skeleton of Accipitridae animal goshawk Accipiter gentilis (Linnaeus).With wind-damp dispelling, continue The effect of muscles and bones.It is usually used in bones and muscles pain, damages fracture.
Eucommia vine, is Apocynaceae Parabarium plant parabarium huaitingii Chun et Tsiang Parabarium huaiting Chun et Tsiang, is used as medicine with old stem and root.With wind-damp dispelling；The effect of bone and muscle strengthening.Main air pain of dampness syndrome；Soreness of the waist and knees；Traumatic injury.
Herba Lycopodii, be lycopsid Lycopodium clavatum Lycopodium jaPonicum Thunb. dry herb.With wind-dispelling Cold expelling. the effect of dehumidification swelling, relaxing muscles and tendons and activating QI and blood in the collateral.For anemofrigid-damp arthralgia, muscle arteries and veins contraction aches carbuncle.External is controlled osteopatia sprain and is swollen and ache.
Caulis et folium clerodendri bungei, is root, the leaf of Verenaceae Clerodendron Caulis et folium clerodendri bungei Clerodendrum bungei Steud. Caulis et folium clerodendri bungei. Detoxify with wind-dispelling, the effect of reducing swelling and alleviating pain.Control carbuncle, furuncle, mastitis, arthritis, eczema, toothache, hemorrhoid, proctoptosis.
Five such as skin, it is the root bark of Asclepiadaceae plant P. sepium Bunge.With the effects such as wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening.Dispelling the wind and dampness pathogens are closed Arthralgia, eczema scrotum, traumatic injury, edema, dysuria.
Herba Paederiae, is the herb of Maguireothamnus speciosus fevervine.Its sweet in the mouth, slight bitter, mild-natured.With expelling wind and removing dampness, pain relieving solution Poison, promoting digestion and removing stagnation, the effect of promoting blood circulation and detumescence.For bones and muscles pain due to rheumatism, traumatic injury, traumatic pain, liver and gall and stomach intestinal colic, Dyspepsia, infantile malnutrition, bronchitis；It is used for outward dermatitis, eczema and sore swollen toxin.
Rhizoma Acori Graminei, is the dry rhizome of acorus gramineus araceae plant Acorus tatarinowii Schott.Removing dampness Appetizing, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.For gastral cavity ruffian is not hungry, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.
Caulis Bauhihiae Championii, is root or the stem of leguminous plant Caulis Bauhiniae Championii.The effect of with expelling wind and removing dampness, promoting flow of QI and blood.Cure mainly rheumatism Arthralgia pain, traumatic injury, hemiplegia, gastric abscess, infantile malnutrition, dysentery.
Radix Flemingiae Philippinensiss, are the root of leguminous plant Flemingia philippinensis.Stop with expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, bone and muscle strengthening, antiinflammatory The effect of pain.Cure mainly rheumatic ostalgia, lumbar muscle strain, hemiplegia, and chronic tracheitiss, mastitis, poliomyelitis sequela, poisonous snake stings Wound.
Caulis Entadae, is the herb of lycopsid Spora Lycopodii Lycopodium clavatum.With expelling wind and dampness, relaxing muscles and tendons and activating QI and blood in the collateral, eliminating stasis to stop pain, profit The effect of urine.Cure mainly arthralgia chiefly caused by damp pathogen apathy, bones and muscles pain, tetany, gonorrhea, traumatic injury, dysuria.
Radix seu Folium Gaultheriae Forrestii, is root or the leaf of ericad Gaultheria forrestii.With the effect of wind-dispelling, dehumidifying.Dispelling the wind and dampness pathogens are paralysed, and freeze Skin ulcer.
Leopard, is the root of campanulaceae money Panthera leopard.With heat clearing away, calm, spleen invigorating QI invigorating, the work(of expelling phlegm for arresting cough Effect.For treatment deficiency of vital energy weak, have loose bowels, cough due to deficiency of the lung, kidney deficiency, infantile malnutrition, milk rareness.
Rhizoma Dioscoreae, is Dioscoreaceae plant Rhizoma Dioscoreae dry rhizome.Have nourish strong, aid digestion, the effect of hold back sweating due to debility, antidiarrheal, Cure mainly insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, diabetes quench one's thirst, oliguria frequency, seminal emission, women's leukorrhagia and dyspeptic chronic enteritiss.
Massa Medicata Fermentata, is the song of Herba polygoni hydropiperis, Herba Artemisiae Annuae, Semen Armeniacae Amarum mud, Semen Phaseoli, fresh Fructus Xanthii addition flour or wheat bran after fermentation Agent.With invigorating the spleen and regulating the stomach, effect of promoting digestion and removing stagnation.For retention of food and drink, dyspepsia, distension and fullness in the abdomen, inappetence, vomiting is rushed down Dysentery.
Caulis Spatholobi, the rattan of leguminous plant spatholobus suberectuss.With relaxing muscles and tendons to promote blood circulation, effect of nourishing blood for regulating menstruation;Cure mainly rheumatic arthralgia, Numb hand and foot, quadriplegia, menoxenia, blockage of menstruation, dysmenorrhea, amenorrhea, leukopenia.
Caulis Piperis Kadsurae, be Piperaceae plant Radix seu Caulis fici Martinii Piper kadsura (Choisy) 0hwi dry rattan.With wind-dispelling Wet, the meridian dredging, effect of stopping numbness pain.For anemofrigid-damp arthralgia, arthrodynia of extremities, muscle arteries and veins contraction, joint stuffiness.
Ramulus Cinnamomi, is the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.With complement sun, lead to blood The effect of arteries and veins, warming the spleen and stomach, treatment insufficiency of kidney-YANG, decline of the fire from the gate of life, cold weak pulse of limb.
Radix Glycyrrhizae, is glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or the dry root of Glycyrrhiza glabra L. Glycyrrhiza glabra L..With invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, Expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity Abdomen, four limbs contraction, carbuncle sore tumefacting virus, alleviate drug toxicity, strong.
The Rhizoma Atractylodis Macrocephalae, is feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz., is used as medicine with rhizome.With dry Effect of wet spleen invigorating, for spleen eating less, dyspepsia, chronic diarrhea, edema, hidroschesis, antiabortive.
Semen Coiciss, are grass Semen Coiciss Coix lacryma-jobi L.var.mayuen (Roman.) Stapf Dry mature kernal.With spleen invigorating eliminating dampness by diuresis, effect of remove numbness antidiarrheal.Semen Coicis can be used to treat edema, tinea pedis, dysuria.
Poria, is the dry sclerotia of On Polyporaceae Poria.With eliminating dampness and diuresises, invigorating the spleen and regulating the stomach, the work(of mind tranquilizing and the heart calming Effect.Control dysuria, oedema turgor, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, have loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful waits disease.
Pericarpium Citri Reticulatae is rutaceae orange Citrus reticulata Blanco and its drying and ripening of variety fruit Skin.With regulating qi-flowing for strengthening spleen, effect of drying dampness to eliminate phlegm.For distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.
Embodiment 1A kind of Chinese medicine composition for treating rheumatoid arthritis
Which is prepared from by the component of following parts by weight：
3 parts of Cortex schizophragmatis integrifolii radiciss, 1.3 parts of Celastrus aceleatus Merr, 1.8 parts of Cortex Ampelopsis Aconitifoliae Radiciss, 2.1 parts of 0rmosia henryi Prain, 1.2 parts of Herba Rubi blinii, 0.5 part of Radix Parthenocissi Heterophyllae, eight 0.25 part of angle maple, 0.2 part of Herba Piperris Tonkinensiss, 0.8 part of snapper eye, 2.2 parts of Pterospermi Heterophylli, 4.5 parts of Artemisia sieversiana Willd., 2.6 parts of Juniperus oxycedruss, Hemerocallis citrina Baroni Cuculus polioephalus 0.8 part, 0.4 part of Sphallerocarpus gracilis, 0.2 part of Althaea rosea (L.) Cavan., 1.7 parts of Cacumen Tamariciss, 0.8 part of Tronae, 0.5 part of eucommia vine, 1.5 parts of Herba Lycopodii, smelly 1.2 parts of Paeonia suffruticosa, five as 1.8 parts of skin, 3.5 parts of Herba Paederiae, 0.6 part of Rhizoma Acori Graminei, 1.25 parts of Caulis Bauhihiae Championii, 1.3 parts of Radix Flemingiae Philippinensiss, Caulis Entadae 0.25 part, 5 parts of Radix seu Folium Gaultheriae Forrestii, 3.5 parts of leopard, 3.5 parts of Rhizoma Dioscoreae, 4.8 parts of Massa Medicata Fermentata, 1.3 parts of Caulis Spatholobi, 1.9 parts of Caulis Piperis Kadsurae, Ramulus Cinnamomi 0.2 part, 4.8 parts of Radix Glycyrrhizae, 6 parts of Os Equi, bear 6 parts of bone, 4.5 parts of the Rhizoma Atractylodis Macrocephalae, 3.4 parts of Semen Coiciss, 4 parts of Poria, 3.8 parts of Pericarpium Citri Reticulatae.
Preparation method, comprises the steps：
（1）The Cortex schizophragmatis integrifolii radiciss of formula ratio are taken, is crushed to 50-100 mesh, add 8 times amount distilled water, heated and boiled 1-3 hour, let cool, Centrifuge 750-900r/min is centrifuged 5-8min, filtration, filtering residue heated and boiled 0.5-1 hour again, centrifuge 750-900r/ Min is centrifuged 3-6min, filtration, and filtering residue adds 4-6 times amount concentration for the ethanol of 70-85%, reflux, extract, 2-4 hour, centrifuge 450-700 r/min is centrifuged 5-8min, filters, 2-3 time repeatedly, merges all of above filtrate, and decompression recycling ethanol, through thin film steaming Sending out the liquid for relative density being concentrated into for 0.75-0.98, obtains Cortex schizophragmatis integrifolii radiciss extracting solution, stand-by；
（2）Take respectively the Celastrus aceleatus Merr of formula ratio, Cortex Ampelopsis Aconitifoliae Radiciss, 0rmosia henryi Prain, Herba Rubi blinii, Radix Parthenocissi Heterophyllae, Radix Alangii, Herba Piperris Tonkinensiss, snapper eye, Pterospermi Heterophylli, Artemisia sieversiana Willd., Juniperus oxycedruss, Hemerocallis citrina Baroni Cuculus polioephalus, Sphallerocarpus gracilis, Althaea rosea (L.) Cavan., Cacumen Tamariciss, Tronae, eucommia vine, Herba Lycopodii, Caulis et folium clerodendri bungei, five such as Skin, Herba Paederiae, Rhizoma Acori Graminei, Caulis Bauhihiae Championii, Radix Flemingiae Philippinensiss, Caulis Entadae, Radix seu Folium Gaultheriae Forrestii, leopard, Rhizoma Dioscoreae, Massa Medicata Fermentata, Caulis Spatholobi, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Radix Glycyrrhizae, respectively according to step（1）Extracting method, obtain the extracting solution of each raw material, stand-by；
（3）Take the Os Equi of formula ratio respectively, bear bone to chop block, add distilled water that 8-10 hour is boiled, bone juice is obtained, stand-by；
（4）Take the Rhizoma Atractylodis Macrocephalae of formula ratio, Semen Coiciss, Poria, Pericarpium Citri Reticulatae respectively, after drying, be crushed to micropowder respectively, then mix equal Even, obtain mixed powder；
（5）By step（1）-（3）The extracting solution for obtaining, bone juice mix, and are slowly at the uniform velocity stirred with stirring paddle, stir 40-45min After become oar material, a small amount of into slurry repeatedly add step（4）Mixed powder, continue stirring, until mix homogeneously, make ball Grain.
Embodiment 2A kind of Chinese medicine composition for treating rheumatoid arthritis
Raw material is weighed by following proportionings respectively, be prepared according to the step in embodiment 1, difference is to be added Proportioning raw materials difference, prepares product：
The proportioning raw materials of embodiment 2：
0.2 part of Cortex schizophragmatis integrifolii radiciss, 0.2 part of Celastrus aceleatus Merr, 0.2 part of Cortex Ampelopsis Aconitifoliae Radiciss, 0.2 part of 0rmosia henryi Prain, 0.2 part of Herba Rubi blinii, 0.2 part of Radix Parthenocissi Heterophyllae, 0.2 part of Radix Alangii, 0.2 part of Herba Piperris Tonkinensiss, 0.2 part of snapper eye, 0.2 part of Pterospermi Heterophylli, 0.2 part of Artemisia sieversiana Willd., 0.2 part of Juniperus oxycedruss, Hemerocallis citrina Baroni Du 0.2 part of cuckoo, 0.2 part of Sphallerocarpus gracilis, 0.2 part of Althaea rosea (L.) Cavan., 0.2 part of Cacumen Tamariciss, 0.2 part of Tronae, 0.2 part of eucommia vine, 0.2 part of Herba Lycopodii, 0.2 part of Caulis et folium clerodendri bungei, five as 0.2 part of skin, 0.2 part of Herba Paederiae, 0.2 part of Rhizoma Acori Graminei, 0.2 part of Caulis Bauhihiae Championii, 0.2 part of Radix Flemingiae Philippinensiss, cross river Dragon 0.2 part, 0.2 part of Radix seu Folium Gaultheriae Forrestii, 0.2 part of leopard, 0.2 part of Rhizoma Dioscoreae, 0.2 part of Massa Medicata Fermentata, 0.2 part of Caulis Spatholobi, 0.2 part of Caulis Piperis Kadsurae, 0.2 part of Ramulus Cinnamomi, 0.2 part of Radix Glycyrrhizae, 5 parts of Os Equi, 5 parts of bone of breast, 2 parts of the Rhizoma Atractylodis Macrocephalae, 2 parts of Semen Coiciss, 2 parts of Poria, 2 parts of Pericarpium Citri Reticulatae.
Embodiment 3A kind of Chinese medicine composition for treating rheumatoid arthritis
Raw material is weighed by following proportionings respectively, be prepared according to the step in embodiment 1, difference is to be added Proportioning raw materials difference, prepares product：
The proportioning raw materials of embodiment 3：
5 parts of Cortex schizophragmatis integrifolii radiciss, 5 parts of Celastrus aceleatus Merr, 5 parts of Cortex Ampelopsis Aconitifoliae Radiciss, 5 parts of 0rmosia henryi Prain, 5 parts of Herba Rubi blinii, 5 parts of Radix Parthenocissi Heterophyllae, 5 parts of Radix Alangii, ten Eight 5 parts of diseases, 5 parts of snapper eye, 5 parts of Pterospermi Heterophylli, 5 parts of Artemisia sieversiana Willd., 5 parts of Juniperus oxycedruss, 5 parts of Hemerocallis citrina Baroni Cuculus polioephalus, 5 parts of Sphallerocarpus gracilis, 5 parts of Althaea rosea (L.) Cavan., 5 parts of Cacumen Tamariciss, 5 parts of Tronae, 5 parts of eucommia vine, 5 parts of Herba Lycopodii, 5 parts of Caulis et folium clerodendri bungei, five as 5 parts of skin, 5 parts of Herba Paederiae, Rhizoma Acori Graminei 5 Part, 5 parts of Caulis Bauhihiae Championii, 5 parts of Radix Flemingiae Philippinensiss, 5 parts of Caulis Entadae, 5 parts of Radix seu Folium Gaultheriae Forrestii, 5 parts of leopard, 5 parts of Rhizoma Dioscoreae, 5 parts of Massa Medicata Fermentata, Caulis Spatholobi 5 Part, 5 parts of Caulis Piperis Kadsurae, 5 parts of Ramulus Cinnamomi, 5 parts of Radix Glycyrrhizae, 7 parts of Os Equi, 7 parts of bone of breast, 6 parts of the Rhizoma Atractylodis Macrocephalae, 6 parts of Semen Coiciss, 6 parts of Poria, Pericarpium Citri Reticulatae 6 Part.
Comparative example 1The Chinese medicine composition for the treatment of rheumatoid arthritiss（Lack the Rhizoma Atractylodis Macrocephalae, Semen Coiciss, Poria, old Skin)
Which is prepared from by the component of following parts by weight：
3 parts of Cortex schizophragmatis integrifolii radiciss, 1.3 parts of Celastrus aceleatus Merr, 1.8 parts of Cortex Ampelopsis Aconitifoliae Radiciss, 2.1 parts of 0rmosia henryi Prain, 1.2 parts of Herba Rubi blinii, 0.5 part of Radix Parthenocissi Heterophyllae, eight 0.25 part of angle maple, 0.2 part of Herba Piperris Tonkinensiss, 0.8 part of snapper eye, 2.2 parts of Pterospermi Heterophylli, 4.5 parts of Artemisia sieversiana Willd., 2.6 parts of Juniperus oxycedruss, Hemerocallis citrina Baroni Cuculus polioephalus 0.8 part, 0.4 part of Sphallerocarpus gracilis, 0.2 part of Althaea rosea (L.) Cavan., 1.7 parts of Cacumen Tamariciss, 0.8 part of Tronae, 0.5 part of eucommia vine, 1.5 parts of Herba Lycopodii, smelly 1.2 parts of Paeonia suffruticosa, five as 1.8 parts of skin, 3.5 parts of Herba Paederiae, 0.6 part of Rhizoma Acori Graminei, 1.25 parts of Caulis Bauhihiae Championii, 1.3 parts of Radix Flemingiae Philippinensiss, Caulis Entadae 0.25 part, 5 parts of Radix seu Folium Gaultheriae Forrestii, 3.5 parts of leopard, 3.5 parts of Rhizoma Dioscoreae, 4.8 parts of Massa Medicata Fermentata, 1.3 parts of Caulis Spatholobi, 1.9 parts of Caulis Piperis Kadsurae, Ramulus Cinnamomi 0.2 part, 4.8 parts of Radix Glycyrrhizae, 6 parts of Os Equi, bear 6 parts of bone.
Preparation method, with embodiment 1.
Comparative example 2Clinical treatment rheumatoid arthritiss common medicine, ibuprofen modified release capsule, sending out for Shanghai love is made Medicine company limited produces.
Below, Example 1-3, the Chinese medicine composition of the obtained treatment rheumatoid arthritiss of comparative example 1 and Comparative example 2 carries out compliance test result, the results are shown in Table 1.
250 patient with rheumatoid arthritis are randomly divided into five groups, per 50 people are organized, then by embodiment 1-3 and right Than the treatment Chinese medicine composition of rheumatoid arthritiss and the ibuprofen modified release capsule of comparative example 2 obtained in embodiment 1 It is respectively issued to five groups of patient with rheumatoid arthritis to use, patient with rheumatoid arthritis patient medication is taken in the same manner With taking 3 times daily, continuously take two courses for the treatment of, each course for the treatment of one month.
Patient diagnosis standard：
Check routine blood test, erythrocyte sedimentation rate, ASO, RF, C reactive protein（CRP）、ANA（Antinuclear antibody）、HLA-B27（Human tissue is compatible Property antigen）
More than checking after seven indexs, diagnosed according to following standard：
（1）More than morning stiffness at least one hour（Continue more than 6 weeks）
（2）3 or more than 3 arthroncuss（Continue more than 6 weeks）
(3) wrist, palm or phalanx joint or proximal interphalangeal joint swelling（Continue more than 6 weeks）
（4）Symmetry arthroncuss（Continue more than 6 weeks）
（5）Subcutaneous nodule
（6）Handss bone X-ray changes
（7）Rheumatoid factor positive（Titre is more than 1：32, there is increase erythrocyte sedimentation rate more）
Possessing in above seven rheumatoid arthritiss is diagnosed as by any four.
Criterion of therapeutical effect：
Implement with reference to State Administration of Traditional Chinese Medicine《In cure the desease Standardization of diagnosis and curative effect》Draft as follows：
Clinical recovery：Tcm clinical practice symptom, sign disappear or basic disappearance；
Effective：Tcm clinical practice symptom, sign substantially change；
Effectively：Tcm clinical practice symptom, sign all take a favorable turn；
Invalid：Tcm clinical practice symptom, sign are all not improved.
Therapeutic outcome such as following table：
Table embodiment 1-3 and the therapeutic outcome of comparative example 1-2
Group Recovery from illness Effective Effectively Invalid Total effective rate
Embodiment 1 13 26 10 1 98%
Embodiment 2 6 19 15 10 80%
Embodiment 3 7 20 14 9 82%
Comparative example 1 4 25 9 12 76%
Comparative example 2 5 23 8 14 72%
Can be seen that, by data in upper table, the Chinese medicine group that patient takes the treatment rheumatoid arthritiss of embodiment of the present invention 1-3 After compound, therapeutic effect shows, the total effective rate of the treatment rheumatoid arthritiss of the present invention reaches more than 80%, wherein embodiment 1 In total effective rate up to 98%.And therapeutic effect is better than clinical common medicine ibuprofen modified release capsule.In addition, the controlling of embodiment 1-3 Therapeutic effect is said than not adding the therapeutic effect of the comparative example 1 of the invigorating the spleen to clear away damp pathogen medicine such as the Rhizoma Atractylodis Macrocephalae, Semen Coiciss, Poria, Pericarpium Citri Reticulatae good Bright Chinese medicine composition of the present invention can also improve patient's gastrointestinal function, be largely avoided and inhibit the poison of some drugses secondary Effect, makes medicine play maximum curative effect, so as to reach the purpose for the treatment of both the principal and secondary aspects of a disease.
It will be apparent to those skilled in the art that technical scheme that can be as described above and design, make other various Corresponding change and deformation, and all these change and deformation should all belong to the protection domain of the claims in the present invention Within.

Claims (6)

1. a kind of Chinese medicine composition for treating rheumatoid arthritiss, it is characterised in that prepared by the component of following weight portion and Become：Cortex schizophragmatis integrifolii radiciss 0.2-5 part, Celastrus aceleatus Merr 0.2-5 part, Cortex Ampelopsis Aconitifoliae Radiciss 0.2-5 part, 0rmosia henryi Prain 0.2-5 part, Herba Rubi blinii 0.2-5 part, triangle Wind 0.2-5 part, Radix Alangii 0.2-5 part, Herba Piperris Tonkinensiss 0.2-5 part, snapper eye 0.2-5 part, Pterospermi Heterophylli 0.2-5 part, Artemisia sieversiana Willd. 0.2-5 Part, Juniperus oxycedruss 0.2-5 part, Hemerocallis citrina Baroni Cuculus polioephalus 0.2-5 part, Sphallerocarpus gracilis 0.2-5 part, Althaea rosea (L.) Cavan. 0.2-5 part, Cacumen Tamariciss 0.2-5 part, Tronae 0.2-5 part, eucommia vine 0.2-5 part, Herba Lycopodii 0.2-5 part, Caulis et folium clerodendri bungei 0.2-5 part, five as skin 0.2-5 part, Herba Paederiae 0.2-5 Part, Rhizoma Acori Graminei 0.2-5 part, Caulis Bauhihiae Championii 0.2-5 part, Radix Flemingiae Philippinensiss 0.2-5 part, Caulis Entadae 0.2-5 part, Radix seu Folium Gaultheriae Forrestii 0.2-5 part, money Leopard 0.2-5 part, Rhizoma Dioscoreae 0.2-5 part, Massa Medicata Fermentata 0.2-5 part, Caulis Spatholobi 0.2-5 part, Caulis Piperis Kadsurae 0.2-5 part, Ramulus Cinnamomi 0.2-5 part, sweet Careless 0.2-5 part, Os Equi 5-7 part, breast bone 5-7 part, Rhizoma Atractylodis Macrocephalae 2-6 part, Semen Coiciss 2-6 part, Poria 2-6 part, Pericarpium Citri Reticulatae 2-6 part.
2. according to claim 1 treatment rheumatoid arthritiss Chinese medicine composition, it is characterised in that by following weight The component of part is prepared from：Cortex schizophragmatis integrifolii radiciss 1.6-3 part, Celastrus aceleatus Merr 1.6-3 part, Cortex Ampelopsis Aconitifoliae Radiciss 1.6-3 part, 0rmosia henryi Prain 1.6-3 part, five pawls Wind 1.6-3 part, Radix Parthenocissi Heterophyllae 1.6-3 part, Radix Alangii 1.6-3 part, Herba Piperris Tonkinensiss 1.6-3 part, snapper eye 1.6-3 part, Pterospermi Heterophylli 1.6-3 Part, Artemisia sieversiana Willd. 1.6-3 part, Juniperus oxycedruss 1.6-3 part, Hemerocallis citrina Baroni Cuculus polioephalus 1.6-3 part, Sphallerocarpus gracilis 1.6-3 part, Althaea rosea (L.) Cavan. 1.6-3 part, Cacumen Tamariciss 1.6-3 part, Tronae 1.6-3 part, eucommia vine 1.6-3 part, Herba Lycopodii 1.6-3 part, Caulis et folium clerodendri bungei 1.6-3 part, five as skin 1.6-3 part, Herba Paederiae 1.6-3 part, Rhizoma Acori Graminei 1.6-3 part, Caulis Bauhihiae Championii 1.6-3 part, Radix Flemingiae Philippinensiss 1.6-3 part, Caulis Entadae 1.6-3 part, Radix seu Folium Gaultheriae Forrestii 1.6-3 part, leopard 1.6-3 part, Rhizoma Dioscoreae 1.6-3 part, Massa Medicata Fermentata 1.6-3 part, Caulis Spatholobi 1.6-3 part, Caulis Piperis Kadsurae 1.6-3 part, osmanthus Branch 1.6-3 part, Radix Glycyrrhizae 1.6-3 part, Os Equi 5.6-6.3 part, breast bone 5.6-6.3 part, Rhizoma Atractylodis Macrocephalae 3.5-4.5 part, Semen Coiciss 3.5-4.5 Part, Poria 3.5-4.5 part, Pericarpium Citri Reticulatae 3.5-4.5 part.
3. according to claim 1 treatment rheumatoid arthritiss Chinese medicine composition, it is characterised in that by following weight The component of part is prepared from：3 parts of Cortex schizophragmatis integrifolii radiciss, 1.3 parts of Celastrus aceleatus Merr, 1.8 parts of Cortex Ampelopsis Aconitifoliae Radiciss, 2.1 parts of 0rmosia henryi Prain, 1.2 parts of Herba Rubi blinii, three 0.5 part of angle wind, 0.25 part of Radix Alangii, 0.2 part of Herba Piperris Tonkinensiss, 0.8 part of snapper eye, 2.2 parts of Pterospermi Heterophylli, 4.5 parts of Artemisia sieversiana Willd., Juniperus oxycedruss 2.6 parts, 0.8 part of Hemerocallis citrina Baroni Cuculus polioephalus, 0.4 part of Sphallerocarpus gracilis, 0.2 part of Althaea rosea (L.) Cavan., 1.7 parts of Cacumen Tamariciss, 0.8 part of Tronae, 0.5 part of eucommia vine, 1.5 parts of Herba Lycopodii, 1.2 parts of Caulis et folium clerodendri bungei, five such as 1.8 parts of skin, 3.5 parts of Herba Paederiae, 0.6 part of Rhizoma Acori Graminei, 1.25 parts of Caulis Bauhihiae Championii, very heavy Pull out 1.3 parts, 0.25 part of Caulis Entadae, 5 parts of Radix seu Folium Gaultheriae Forrestii, 3.5 parts of leopard, 3.5 parts of Rhizoma Dioscoreae, 4.8 parts of Massa Medicata Fermentata, 1.3 parts of Caulis Spatholobi, sea 1.9 parts of Radix seu Caulis fici Martinii, 0.2 part of Ramulus Cinnamomi, 4.8 parts of Radix Glycyrrhizae, 6 parts of Os Equi, bear 6 parts of bone, 4.5 parts of the Rhizoma Atractylodis Macrocephalae, 3.4 parts of Semen Coiciss, 4 parts of Poria, 3.8 parts of Pericarpium Citri Reticulatae.
4. a kind of preparation method of the Chinese medicine composition of the treatment rheumatoid arthritiss as described in any one of claim 1-3, Characterized in that, comprising the steps：
（1）The Cortex schizophragmatis integrifolii radiciss of formula ratio are taken, is crushed to 50-100 mesh, add 8 times amount distilled water, heated and boiled 1-3 hour, let cool, Centrifuge 750-900r/min is centrifuged 5-8min, filtration, filtering residue heated and boiled 0.5-1 hour again, centrifuge 750-900r/ Min is centrifuged 3-6min, filtration, and filtering residue adds 4-6 times amount concentration for the ethanol of 70-85%, reflux, extract, 2-4 hour, centrifuge 450-700 r/min is centrifuged 5-8min, filters, 2-3 time repeatedly, merges all of above filtrate, and decompression recycling ethanol, through thin film steaming Sending out the liquid for relative density being concentrated into for 0.75-0.98, obtains Cortex schizophragmatis integrifolii radiciss extracting solution, stand-by；
（2）Take respectively the Celastrus aceleatus Merr of formula ratio, Cortex Ampelopsis Aconitifoliae Radiciss, 0rmosia henryi Prain, Herba Rubi blinii, Radix Parthenocissi Heterophyllae, Radix Alangii, Herba Piperris Tonkinensiss, snapper eye, Pterospermi Heterophylli, Artemisia sieversiana Willd., Juniperus oxycedruss, Hemerocallis citrina Baroni Cuculus polioephalus, Sphallerocarpus gracilis, Althaea rosea (L.) Cavan., Cacumen Tamariciss, Tronae, eucommia vine, Herba Lycopodii, Caulis et folium clerodendri bungei, five such as Skin, Herba Paederiae, Rhizoma Acori Graminei, Caulis Bauhihiae Championii, Radix Flemingiae Philippinensiss, Caulis Entadae, Radix seu Folium Gaultheriae Forrestii, leopard, Rhizoma Dioscoreae, Massa Medicata Fermentata, Caulis Spatholobi, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Radix Glycyrrhizae, respectively according to step（1）Extracting method, obtain the extracting solution of each raw material, stand-by；
（3）Take the Os Equi of formula ratio respectively, bear bone to chop block, add distilled water that 8-10 hour is boiled, bone juice is obtained, stand-by；
（4）Take the Rhizoma Atractylodis Macrocephalae of formula ratio, Semen Coiciss, Poria, Pericarpium Citri Reticulatae respectively, after drying, be crushed to micropowder respectively, then mix equal Even, obtain mixed powder；
（5）By step（1）-（3）The extracting solution for obtaining, bone juice mix, and are slowly at the uniform velocity stirred with stirring paddle, stir 40-45min After become oar material, a small amount of into slurry repeatedly add step（4）Mixed powder, continue stirring, until mix homogeneously, make ball Grain.
5. according to claim 4 treatment rheumatoid arthritiss Chinese medicine composition preparation method, it is characterised in that The Rhizoma Atractylodis Macrocephalae, Semen Coiciss, Poria, Pericarpium Citri Reticulatae are all ground into micropowder.
6. according to claim 4 treatment rheumatoid arthritiss Chinese medicine composition preparation method, it is characterised in that The Rhizoma Atractylodis Macrocephalae, Semen Coiciss, Poria, Pericarpium Citri Reticulatae mean diameter are all more than 300 mesh.
CN201611099796.6A 2016-12-05 2016-12-05 Traditional Chinese medicinal composition for treating rheumatoid arthritis and preparation method thereof Pending CN106421534A (en)

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Application publication date: 20170222