CN106421494A - Application of asparagus extract in preparation of health-care products or health-care drugs for promoting and improving memory - Google Patents
Application of asparagus extract in preparation of health-care products or health-care drugs for promoting and improving memory Download PDFInfo
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- 230000001737 promoting effect Effects 0.000 title abstract 5
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides new purposes of an asparagus extract. The asparagus extract can be eaten by serving as a substance with the memory promoting and improving effects separately or be used for preparing food or health-care food or health-care drugs with the memory promoting and improving effects. The asparagus extract can effectively promote and improve the memory ability of people, and therefore the asparagus extract can be eaten separately by serving as the food or prepared into the corresponding food or health-care food or drugs which are used for promoting and improving the memory of people and can achieve the good memory promoting and improving health care or medical treatment effects.
Description
Technical field
The present invention relates to plant extract field, it is used for being lifted in particular to Germinatus Phragmitis extract and improves memory
New application.
Background technology
Cognitive and memory is the basic activity of the mankind.By sides such as life stress increase, aged tendency of population and living environments
The phenomenon that the impact in face, people's cognition and memory function decline is more and more universal, and this is to people, and normal life also result in
Increasing puzzlement.
The cognitive and more prevalent concrete reason of hypomnesis phenomenon mainly has following two aspects.On the one hand, be by
In development, the aggravation competing of social economy, the subhealth state that body is in a kind of asthenia, energy is inadequate or the whole body is tired can be led to
State, body occurs different degrees of physiology, mental maladjustment.Sub-health state, not only can cause tissue fatigue for a long time,
Nervus centraliss fatigue more can be caused.By the development of the technology such as Electrophysiology in recent years, biological microdialysiss, find subhealth state shape
Central fatigue under state can lead to remember the decline with cognitive competence, the acetylcholine (Ach) in central nervous system, dopamine
(DA), 5-hydroxy tryptamine (5-HT), γ-aminobutyric acid equal size all can change, and then affect the memory of human body and cognitive work(
Energy.On the other hand, under the promotion of natality minimizing and life, in world wide, aging population appearance is not seen before
Increase.For China, by the end of the year 2013,60 one full year of life and above population about 200,000,000, account for the 14.9% of total population, 65 one full year of life and
Above population about 1.3 hundred million, accounts for the 9.7% of total population, and China steps into aging society already.Under this trend, except normal
Amnesia outside, age related Memory and Cognition obstacle number also dramatically increases, modal i.e. Alzheimer
(Alzheimer disease, AD).The U.S. has 5,300,000 patients with Alzheimer disease in 2003, and number significantly increases year by year
Plus.According to estimates, China's patients with Alzheimer disease nearly 6,000,000 in 2011, is up to 20,000,000 to the middle of this century.Also promising number
More Patients with Mild Cognitive Impairments, this stage is eventually changed into Alzheimer.Additionally, infirmities of age such as parkinson,
Vascular conditions etc. equally can cause the cognitive decline with memory function.So, exploitation has lifting and the work(improving memory
Can product not still market demand, be also the demand in epoch.
Germinatus Phragmitiss are a kind of food with good health care.China's Asparagus Industry was started to walk from the seventies in last century, at present
1,700,000 mu of cultivated area, cultivated area, total output and processing trade volume all row the first in the world, are China's fruits and vegetables product trades
Easily middle outlet amount maximum kind.But Germinatus Phragmitiss comprehensive utilization technique is in and compares the lag phase, is mainly manifested in the wasting of resources tight
Weight, process technology fall behind, Germinatus Phragmitiss functional component research and using being still in theoretical research stage.Germinatus Phragmitiss functional component is opened both at home and abroad
Send out and purposes research field much all in blank, effective ingredient exploitation and using also needing to substantial amounts of scientific research in Germinatus Phragmitiss
Explored with test and developed.
In view of this, the special proposition present invention.
Content of the invention
The first object of the present invention is to provide a kind of new application of Germinatus Phragmitis extract, and in the present invention, Germinatus Phragmitis extract can
Effectively lift and improve the memory ability of human body it is thus possible to as lifting and improve the wholefood of human body memory, individually
Edible, or be used for preparing corresponding food, health food or medicine as raw material, and good lifting can be reached and change
The health care of kind memory or medical effect.
In order to realize the above-mentioned purpose of the present invention, spy employs the following technical solutions：
The invention provides a kind of new application of Germinatus Phragmitis extract is it is characterised in that described Germinatus Phragmitis extract can conduct
Lifting and the food improving memory, and individually eat；Or described Germinatus Phragmitis extract can be as raw material and for preparation tool
There are lifting and the food or the medicine that improve memory.
Optionally, in the present invention, described medicine can be the OTC (over-the-counter) with stable therapeutical effect Small side effects；
And/or described medicine can be the ethical goods with definite therapeutic effect.
Optionally, in the present invention, described food is to have the health food adjusting function of human body, having specific function；With/
Or described food is common meal replacing food.
Optionally, in the present invention, described extract is asparagus extract or Germinatus Phragmitiss dry powder.
Optionally, in the present invention, in described asparagus extract, the content of Germinatus Phragmitiss saponin is >=0.3g/100ml, Germinatus Phragmitiss dry powder
The content of middle Germinatus Phragmitiss saponin is >=1.2g/100g
Optionally, in the present invention, the preparation method of described Germinatus Phragmitis extract comprises the steps：After raw material Germinatus Phragmitiss are pulverized
Soak, and after boiling extraction filtration, obtain extracting solution；Then, by extracting solution after activated carbon adsorption, electrode membrane filtration, obtain
To asparagus extract；Then, by after asparagus extract concentrate drying, obtain Germinatus Phragmitiss dry powder.
In the present invention, extracted by pulverizing Germinatus Phragmitiss, and be filtered to remove heavy metal through activated carbon adsorption, electrode film further
With prepare Germinatus Phragmitis extract after pesticide residue such that it is able to harmful substance residual less Germinatus Phragmitis extract is obtained, and have
Easy and simple to handle, extraction efficiency is high, the advantages of obtained Germinatus Phragmitis extract purity is good.
In the present invention, described raw material Germinatus Phragmitiss are new fresh asparagus, be dried after Germinatus Phragmitiss, old stalk of asparagus or asparagus straws.
Optionally, in the present invention, described boiling is extracted as heating water used to the Germinatus Phragmitiss after soaking and immersion together
To boiling water, and extracted.
Optionally, in the present invention, the described normal pressure that is extracted as extracts, is extracted under high pressure extract or ultrasound condition.
Optionally, in the present invention, described immersion is to soak 20～120min with the water of 2～10 times of volumes of Germinatus Phragmitiss raw material；Example
As 20 can be soaked with the water of Germinatus Phragmitiss raw material 3,4,5,6,7,8,9 volume, 40,60,80,105,120min etc..
Optionally, in the present invention, the time of described extraction is 30～90min；The time of such as extraction can be but not limit
In 35,40,45,50,55,60,65,70,75,80,85min etc..
Optionally, in the present invention, the activated carbon addition of described activated carbon adsorption is the 3-8% of extracting solution weight, for example
Activated carbon addition can be for but is not limited to 3%, 4%, 5%, 6%, 7%, 8% of extracting solution weight etc..
Optionally, in the present invention, the time of contact of described activated carbon adsorption is 15-120min, such as activated carbon adsorption
Time of contact can be but be not limited to 15min, 20min, 45min, 80min, 105min, 110min, 120min etc..
Optionally, in the present invention, the thickness of electrode film is 0.15～1.0mm；The thickness of such as electrode film can for but not
It is limited to 0.20mm, 0.25mm, 0.30mm, 0.40mm, 0.50mm, 0.60mm, 0.70mm, 0.75mm, 0.80mm, 0.95mm etc..
Optionally, in the present invention, described electrode film is by hydroaropic substance, adsorbent, conductive material and bonding
Overstock after agent mixing, roll the electrode film preparing, and removing heavy-metal residual is adsorbed by energising.Further, institute
Stating hydroaropic substance is silica gel or hydrophilic cellulose；Described adsorbent be activated carbon, sintering, porous volcanic rock granule or
Person's graphite；Described conductive material is graphite or white carbon black；Described adhesive is polyurethane, silicone, PCTFE or PFA.
Optionally, in the present invention, described concentration as the content being concentrated into solid matter in asparagus extract is 20～40%；
For example can be concentrated into solid matter in asparagus extract content be 22%, 25%, 27%, 29%, 32%, 35%, 37%,
39% etc..
Optionally, in the present invention, described drying is to be spray-dried or lyophilizing.
Optionally, in the present invention, described spray drying is to be dried under the conditions of 130～200 DEG C using spray drying tower；Example
As done under the conditions of 135 DEG C, 140 DEG C, 145 DEG C, 150 DEG C, 160 DEG C, 165 DEG C, 170 DEG C, 180 DEG C, 190 DEG C, 195 DEG C
Dry.
Optionally, in the present invention, described lyophilizing is that the water content in the extract to after concentrate for the lyophilizing is less than 5%.
Compared with prior art, beneficial effects of the present invention are：
Germinatus Phragmitis extract of the present invention can effectively be lifted and improve human body memory, and is further prepared into eating accordingly
Product, health food or medicine, can also play good health care or medical effect simultaneously；Meanwhile, Germinatus Phragmitis extract of the present invention
Middle heavy metal and pesticide remnant amount is few, and edible safety is high.
Specific embodiment
Below in conjunction with embodiment, embodiment of the present invention is described in detail, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and be not construed as limiting the scope of the present invention.Unreceipted concrete in embodiment
Condition person, the condition according to normal condition or manufacturer's suggestion is carried out.Agents useful for same or the unreceipted production firm person of instrument, are
Can be by the commercially available conventional products bought and obtain.
Embodiment 1
After taking proper amount of fresh Germinatus Phragmitiss to pulverize, soak 40min with the water of 2 times of volumes；Then, under elevated pressure conditions, will soak
After having pulverizing, 50min is extracted in the decocting in water boiling of Germinatus Phragmitiss, and filters, and obtains extracting solution；Then, by the ratio in extracting solution weight 4%
60min is contacted after adding activated carbon, then the electrode film energising adsorption filtration for 0.15mm through thickness, obtain asparagus extract, that is,
Asparagus extract for embodiment 1；
Then, content asparagus extract being concentrated into solid matter in asparagus extract is 40%, then in 150 DEG C of bars
It is spray-dried under part, obtain Germinatus Phragmitiss dry powder, as the Germinatus Phragmitiss dry powder of embodiment 1.
Embodiment 2
After taking proper amount of fresh Germinatus Phragmitiss to pulverize, soak 20min with the water of 10 times of volumes；Then, under elevated pressure conditions, will soak
After having pulverizing, 50min is extracted in the decocting in water boiling of Germinatus Phragmitiss, and filters, and obtains extracting solution；Then will add in the ratio of extracting solution weight 6%
After contacting 15min after entering activated carbon, then the electrode film energising adsorption filtration for 0.35mm through thickness, obtain asparagus extract, that is,
Asparagus extract for embodiment 2；
Then, content asparagus extract being concentrated into solid matter in asparagus extract is 35%, then in 150 DEG C of bars
It is spray-dried under part, obtain Germinatus Phragmitiss dry powder, as the Germinatus Phragmitiss dry powder of embodiment 2.
Embodiment 3
By obtained asparagus extract in embodiment 1 through high-temperature instantaneous sterilization, canned, sealing, coding, cooling, inspection,
Packaging and other steps make asparagus juice, as the no added food of pure natural, can individually eat, and reach lifting and improve memory effect
Really.
Embodiment 4
Germinatus Phragmitiss dry powder 2000g in Example 1, adds starch 800g, through sieving, mixing, pelletize, be dried, granulate, dress
The steps such as capsule, prepared Germinatus Phragmitis extract capsule, as health food, in order to be lifted and to improve memory.
Test example 1 water maze laboratory (Maze test)
Maze test is the most test of research animal learning memory ability application both at home and abroad, and Morris water maze laboratory is
One kind forces laboratory animal to swim, and a kind of experiment being hidden in underwater platform is found in study, is mainly used in test experiments animal pair
The ability of learning and memory with direction sensation (space orientation) is felt in locus.More classical Morris water maze testing experiment is main
Test (Localization navigation test) including orientation navigation or be hiding platform test (Hidden
Platform test) and space exploration test (Spatial probe test) two parts.Wherein orientation navigation test is passed through
Record animal searches out in test time (escape latency, escape latency), the swimming being hidden in water surface lower platform
The indexs such as total path, swimming rate carry out the learning capacity difference of analyzing animal.Space exploration test is after orientation navigation test
Remove platform, then total by recording its swimming track within a certain period of time, the number of times through original platform region for the mice, swimming
Path, in the land regions total path swimming index such as total path, the memory ability of animal is investigated with this.
66 4 week old (20-25g) SPF level male ICR mouses are chosen, the daily cycle is maintained at 8 in experiment：00/20:00,
23 ± 2 DEG C of room temperature, humidity 60%, mice starts normal experiment after raising in advance 1 week.
By mice according to randomly assigne, be divided into blank control group, model group, hydrochloric acid to donepezil group (positive controls),
Low dosage asparagus extract group, middle dosage asparagus extract group, high dose asparagus extract group, totally 6 groups, wherein blank control group
For 6, remaining is 10.With 0.9% normal saline gavage, positive controls are with 35mg/kg potato for blank control group and model group
Chinese yam saponin aqueous solution gavage, then with 4mg/kg donepezil hydrochloride aqueous solution gavage, low dosage asparagus extract group, middle dosage
Asparagus extract group, high dose asparagus extract group gavage asparagus extract (100ml/kg, 500ml/kg, 1000ml/ respectively
Kg), continuous gavage 4 weeks.
Experiment starts front 30min and carries out lumbar injection to mice, in addition to the normal saline of blank group lumbar injection 0.9%,
Remaining each group equal lumbar injection hyoscine hydrobromate (1mg/kg) manufactures dysmnesia model.
Normal Mice water maze experimental result be see table：
Table 1 Germinatus Phragmitis extract tests the impact (X ± SD) of Memory acquisition to normal Mice water maze
Compare * p with blank group>0.05,**p<0.05,***p<0.01
Table 2 Germinatus Phragmitis extract tests the impact (X ± SD) of memory consolidation to normal Mice water maze
Compare * p with blank group>0.05,**p<0.05,***p<0.01
The impact (X ± SD) that table 3 Germinatus Phragmitis extract reproduces to the experiment memory of normal Mice water maze
Compare * p with blank group>0.05,**p<0.05,***p<0.01
Obstacle Mice water maze experimental result be see table.
Table 4 Germinatus Phragmitis extract tests the impact (X ± SD) of Memory acquisition to obstacle Mice water maze
Obstacle group compares #p with blank group>0.05,##p<0.05,###p<0.01
Compare * p with blank group>0.05,**p<0.05,***p<0.01
Table 5 Germinatus Phragmitis extract tests the impact (X ± SD) of memory consolidation to obstacle Mice water maze
Obstacle group compares #p with blank group>0.05,##p<0.05,###p<0.01
Compare * p with blank group>0.05,**p<0.05,***p<0.01
The impact (X ± SD) that table 6 Germinatus Phragmitis extract reproduces to the experiment memory of obstacle Mice water maze
Obstacle group compares #p with blank group>0.05,##p<0.05,###p<0.01
Compare * p with blank group>0.05,**p<0.05,***p<0.01
Result of the test shows：Germinatus Phragmitis extract is consolidated to normal mouse memory, Memory acquisition and memory reproduce index and all have
The effect significantly improving；To drug-induced memory acquisition disturbance group, memory consolidation obstacle group, reproducibility dysmnesia group mice
Memory consolidation, Memory acquisition and memory reproduce index and are all significantly improved effect, illustrates that Germinatus Phragmitis extract has to be lifted and remember energy
The function of power.
Test example 2 Jumping test (Step-down test)
Research is main to apply the number of times (errors number) that in step down test, animal is shocked by electricity, jumps off the latent of platform for the first time
The indexs such as the wrong sum in volt phase and certain time are analyzing the learning capacity difference of mice.
Taking male ICR mouse to be divided at random by body weight size is divided into blank control group, hydrochloric acid (positive right to donepezil group
According to group), low dosage asparagus extract group, middle dosage asparagus extract group, five groups of high dose asparagus extract group, blank control group
With 0.9% normal saline gavage, hydrochloric acid to donepezil group with 35mg/kg dioscin aqueous solution gavage, then with 4mg/kg salt
Sour donepezil aqueous solution gavage, low dosage asparagus extract group, middle dosage asparagus extract group, high dose asparagus extract group
Gavage asparagus extract (100ml/kg, 500ml/kg, 1000ml/kg), continuously gives sample 35 days respectively.
Dysmnesia model manufacture method is that experiment starts front 30min and carries out lumbar injection to mice, except blank group abdominal cavity
Outside the normal saline of injection 0.9%, remaining each group equal lumbar injection hyoscine hydrobromate (1mg/kg).
Next day after last dose, (or 1h after once giving sample) started to train.Animal is put into (on platform, under platform) in reaction chamber
Adapt to environment 3min, then by the copper grid in animal placing response case, pass to the alternating current of 36v immediately.Animal is shocked by electricity,
Its normal reaction is rebound platform (insulator), to hide noxious stimulation.Most animals may skip to copper grid again or repeatedly
On, snapped back on platform by electric shock again.After training once, animal is placed on the platform in reaction chamber, in record 5min
Each Mus jump off the errors number of platform and the incubation period jumping off platform for the first time, in this, as school grade (Memory acquisition).24
Or carry out resurveying after 48h testing, mice is placed on platform, recording each Mus first time jumps off the incubation period of platform, in each Mus 3min
Number of shocks and the number of animals sum being shocked by electricity, calculate the percentage rate (animal shocked by electricity of animal wrong reaction simultaneously
Number accounts for the percentage rate of this group animal number) (memory consolidation).Deconditioning (included the 5th day) after 5 days can be in the different time
Once remembered experiment of disappearing (memory reproduces).
Result see table：
The impact (X ± SD) to normal mouse Jumping test for table 7 Germinatus Phragmitis extract
Compare * p with normal blank group>0.05,**p<0.05,***p<0.01
The impact (X ± SD) to obstacle mice Jumping test for table 8 Germinatus Phragmitis extract
Obstacle group compares #p with blank group>0.05,##p<0.05,###p<0.01
Compare * p with normal blank group>0.05,**p<0.05,***p<0.01
Result of the test shows：In Jumping test, Germinatus Phragmitis extract is to the acquisition of normal group mouse memory, memory consolidation and memory
Reproduce index to be all significantly improved effect, to drug-induced memory acquisition disturbance group, memory consolidation obstacle group, memory reproduction
Obstacle group mouse memory obtains, memory consolidation and memory reproduce index and be all significantly improved effect.This Germinatus Phragmitis extract has and changes
The effect of kind memory function.
Human feeding trial
The improvement result to human body memory ability for test example 3 Germinatus Phragmitis extract
According to《Health food inspection and assessment technique specification》The human body examination of auxiliary improving memory function in (version in 2003)
Food testing regulationss are carried out, and press, using Clinical Memory Test, the memory quotient that test request measures experimenter.Test-meal group takes Germinatus Phragmitiss
Extract 100ml/d, matched group takes the placebo of same dose, continuously takes 1 month.Test-meal is in accordance with double blinding principle.
Two groups of each subtests scale score situation (X ± SD) before and after table 9 test-meal
Memory quotient situation (X ± SD) before and after table 10 liang of groups test-meal
Result of the test shows：After edible Germinatus Phragmitis extract, exclude the impact of other factors by matched group, find to point to and learn
Habit, learning by association, random shape are re-recognized, image is freed recall and the contact of portrait feature recall test-meal after table divide and be above test-meal
Before.Test-meal group memory quotient is significantly higher than matched group, before after test-meal group test-meal simultaneously, memory quotient is significantly higher than test-meal.Show reed
Radix Crotalariae szemoensis extract has the function of lifting memory to experimenter.
As can be seen here, Germinatus Phragmitis extract of the present invention has good health properties, and can effectively be lifted and improve memory
Power.Meanwhile, extracted in the Germinatus Phragmitis extract obtaining with heretofore described method, effectively eliminate heavy metal and pesticide remnant,
Safety is good.
Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that without departing substantially from the present invention's
Many other changes can be made in the case of spirit and scope and change.It is, therefore, intended that in the following claims
Including all such changes and modifications belonging in the scope of the invention.
Claims (10)
1. the purposes of Germinatus Phragmitis extract is it is characterised in that described Germinatus Phragmitis extract can be used as lifting and the food improving memory
Product, and individually eat；Or described Germinatus Phragmitis extract can have lifting as raw material and for preparation and improve memory
Food or medicine.
2. purposes according to claim 1 is it is characterised in that described extract is asparagus extract or Germinatus Phragmitiss dry powder.
3. purposes according to claim 1 it is characterised in that in described asparagus extract Germinatus Phragmitiss saponin content be >=
0.3g/100ml, in Germinatus Phragmitiss dry powder, the content of Germinatus Phragmitiss saponin is >=1.2g/100g.
4. purposes according to claim 1 is it is characterised in that the preparation method of described Germinatus Phragmitis extract is as follows：By raw material
Germinatus Phragmitiss are soaked after pulverizing, and after boiling extraction filtration, obtain extracting solution；Then, by extracting solution through activated carbon adsorption, electrode film
After filtering purification, obtain asparagus extract；Then, by after asparagus extract concentrate drying, obtain Germinatus Phragmitiss dry powder.
5. purposes according to claim 4 is it is characterised in that described immersion is with the water of 2～10 times of volumes of Germinatus Phragmitiss raw material
Soak 20～50min.
6. purposes according to claim 4 is it is characterised in that the time of described extraction is 30～90min.
7. purposes according to claim 4 is it is characterised in that the activated carbon addition of described activated carbon adsorption is extracting solution
The 3-8% of weight, the time of contact of described activated carbon adsorption is 15-120min.
8. purposes according to claim 4 is it is characterised in that the thickness of described electrode film is 0.15～1.0mm.
9. purposes according to claim 4 is it is characterised in that described concentration is to be concentrated into solid matter in asparagus extract
Content be 10～40%.
10. purposes according to claim 4 is it is characterised in that described drying is to be spray-dried or lyophilizing.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106963897A (en) * | 2017-04-12 | 2017-07-21 | 广州市天河华南发展有限公司 | A kind of Germinatus Phragmitis extract and its preparation method and application |
| CN107252021A (en) * | 2017-07-10 | 2017-10-17 | 秦皇岛长胜营养健康科技有限公司 | Reduce asparagus drink of Intima-medial thickness effect and its preparation method and application |
| CN107348276A (en) * | 2017-07-24 | 2017-11-17 | 秦皇岛长胜营养健康科技有限公司 | A kind of method for improving concentration asparagus juice bioavilability and asparagus drink and application |
| CN108714192A (en) * | 2018-06-22 | 2018-10-30 | 秦皇岛长胜营养健康科技有限公司 | Composition for improving cerebral nerve trophic function and its application |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101031337A (en) * | 2004-09-22 | 2007-09-05 | 普兰提纳开发有限责任公司 | Extracts from roots and/or shoots of asparagus officinalis l., their preparation and their use |
| CN101919970A (en) * | 2009-06-09 | 2010-12-22 | 张凤文 | Asparagus based preparation for improving human immunity and preventing and treating cardiovascular and cerebrovascular diseases |
| CN102293381A (en) * | 2011-09-20 | 2011-12-28 | 秦皇岛长胜农业科技发展有限公司 | Instant asparagus powder |
| CN103444963A (en) * | 2013-09-29 | 2013-12-18 | 吴茂萱 | Asparagus tea |
| CN103519167A (en) * | 2013-10-08 | 2014-01-22 | 秦皇岛长胜农业科技发展有限公司 | Instant asparagus powder food with new applications of relieving pressure and improving memory |
| CN104743644A (en) * | 2013-12-27 | 2015-07-01 | 日本华尔卡工业株式会社 | Electrode film for water treatment and its preparation method and use |
| CN105617867A (en) * | 2016-01-11 | 2016-06-01 | 合肥科佳高分子材料科技有限公司 | Method for removing heavy metal ions from asparagus saponin extraction liquid |
-
2016
- 2016-12-01 CN CN201611088143.8A patent/CN106421494A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101031337A (en) * | 2004-09-22 | 2007-09-05 | 普兰提纳开发有限责任公司 | Extracts from roots and/or shoots of asparagus officinalis l., their preparation and their use |
| CN101919970A (en) * | 2009-06-09 | 2010-12-22 | 张凤文 | Asparagus based preparation for improving human immunity and preventing and treating cardiovascular and cerebrovascular diseases |
| CN102293381A (en) * | 2011-09-20 | 2011-12-28 | 秦皇岛长胜农业科技发展有限公司 | Instant asparagus powder |
| CN103444963A (en) * | 2013-09-29 | 2013-12-18 | 吴茂萱 | Asparagus tea |
| CN103519167A (en) * | 2013-10-08 | 2014-01-22 | 秦皇岛长胜农业科技发展有限公司 | Instant asparagus powder food with new applications of relieving pressure and improving memory |
| CN104743644A (en) * | 2013-12-27 | 2015-07-01 | 日本华尔卡工业株式会社 | Electrode film for water treatment and its preparation method and use |
| CN105617867A (en) * | 2016-01-11 | 2016-06-01 | 合肥科佳高分子材料科技有限公司 | Method for removing heavy metal ions from asparagus saponin extraction liquid |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106963897A (en) * | 2017-04-12 | 2017-07-21 | 广州市天河华南发展有限公司 | A kind of Germinatus Phragmitis extract and its preparation method and application |
| CN107252021A (en) * | 2017-07-10 | 2017-10-17 | 秦皇岛长胜营养健康科技有限公司 | Reduce asparagus drink of Intima-medial thickness effect and its preparation method and application |
| CN107348276A (en) * | 2017-07-24 | 2017-11-17 | 秦皇岛长胜营养健康科技有限公司 | A kind of method for improving concentration asparagus juice bioavilability and asparagus drink and application |
| CN107348276B (en) * | 2017-07-24 | 2021-05-18 | 秦皇岛长胜营养健康科技有限公司 | Method for improving bioavailability of concentrated asparagus juice, asparagus drink and application |
| CN108714192A (en) * | 2018-06-22 | 2018-10-30 | 秦皇岛长胜营养健康科技有限公司 | Composition for improving cerebral nerve trophic function and its application |
| CN108714192B (en) * | 2018-06-22 | 2021-04-27 | 黄云祥 | Composition for improving brain neurotrophic function and application thereof |
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