CN106421155A - Drug for treating allergic rhinitis - Google Patents
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Abstract
The invention belongs to the technical field of medicine, and particularly relates to a drug for treating allergic rhinitis. The drug is prepared through fixing, frying, grinding, ethanol extracting, distillation extracting, decoction extracting, concentration, mixing, encapsulating and sterilizing of 10g of fresh leaves of aquilaria sinensis, 10g of fresh urena lobata herbs, 5g of cortex phellodendri, 5g of cortex moutan and 2g of trehalose. The obtained drug can be made into lipidosome liquid. A user can drip the drug into the nose, dips absorbent cotton in the drug and plugs the absorbent cotton into the nose, or guides the drug through atomization, so that anaphylactic reactions can be removed quickly, and curative effect can be achieved.
Description
Technical field
The invention belongs to pharmaceutical technology field, treat allergic rhinitises medicament particularly to one kind.
Background technology
Allergic rhinitises, i.e. allergic rhinitis, refer to the medium that atopic individuals are mainly mediated after contacting allergen by lgE
(mainly histamine) discharges, and has the nasal mucosa non-infectious inflammatory disease of the participations such as panimmunity competent cell and cytokine
Disease.Also has a kind of cacorhinia, modern medicine is referred to as vasomotor rhinitiies, and its symptom is also much like with allergic rhinitises, also has
Typical clear nasal discharge and sneeze, but its mechanism is vegetative nerve, endocrine adjusts not normal drawing to the blood vessel of nasal mucosa, Intervention
Rise.
Although modern medicine can explain the pathogeny of above-mentioned rhinitis in more detail, also can adopt for different pathological types
Obtain certain curative effect with the corresponding Drug therapy such as such as antihistamine, glucocorticoid, anticholinergic, but all cannot thoroughly control
Heal, and large side effects.
The traditional Chinese medical science just had discussion primary disease, referred to as allergic rhinitis, nasal sinusitis before thousand of years, in the successive dynasties doctor also develop many
Treatment prescription and method, the such as guizhi decoction of warming lung for dispelling cold and Ephedrae Decoction, the YUPINGFENG SAN of benefiting QI for strengthening the superficies, the benefit of replenishing QI to invigorate the spleen yang invigorating
Middle Qi-benefiting decoction, the Zhen Wu Tang, Decoction for strengthening the Spleen-Yang of warming YANG to promote diuresis, the Lonicerae and Forsythiae Powder of wind-dispelling heat-dissipating, and various external pulvis and drip, wash Chinese medicine, can not
Deny, it also can produce effects in terms of improving body constitution and mitigation symptoms, but anaphylactoid many symptoms of nose still cannot
Eradicate, be difficult to cure.
Content of the invention
The present inventor, by carrying out in-depth study to the rhinitis of similar allergic rhinitis symptoms, is closed in conjunction with to of all times
Analysis in the discussion of such disease finds, the immunocompetence of human body and primary disease are the relations having reciprocal causation, Wo Mentong
Often only emphasize due to the immunity of human body not strong, primary disease just can occur, but not pay attention to the symptom that primary disease long-term morbidity occurs
Itself, the immunity that also can make us body is constantly impaired, and yang-energy cannot be restrained rehabilitation, defines vicious cycle.Understand
This point, just should crucial focus on the local route repair of nasal mucosa, in the appearance that prevents from induce ill symptom, to patient
Obtain the time of rehabilitation, because human body is the self-rehabilitation ability with mystery in itself, as long as can give body good propping up
Hold and the time, need not be using excessive Drug therapy, the rehabilitation instinct of human body is can to realize fully recovering completely.However, making a general survey of
Treat the medication of above-mentioned rhinitis, the blocker of Western medicine, Claritin, hormone, or even the abuse of antibiotic at all times, all repeatedly
Disturb the ecological environment of nose.Even the traditional Chinese medical science, also commonly use such as Herba Pogostemoniss, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Xin Maihua, Borneolum Syntheticum, Herba Schizonepetae, fiber crops
The stimulating drug of the acidities such as Huang, Fructus Xanthii, Fructus Foeniculi, defends tenaciously the theory medication of wind dispelling cold expelling, and result is so that nasal mucosa is subject to
Stimulation repeatedly, not only can not effect a radical cure allergic rhinitises, so that the touching difficulty of the state of an illness is healed on the contrary, this kind of topical agent is in the patent literature
Also can be found everywhere, really regrettable.
Inventors believe that, no matter being the medium release that allergen causes, or nerve, endocrine to the blood vessel of nasal mucosa,
Intervention adjust not normal, all related to the stimulation that nasal mucosa cell is subject to, the present invention has screened substantial amounts of Chinese herbal medicine, with sweet,
Light, amara is drug choice, avoids dripping of irritant drugs first, then from the property of medicine, functionally test and screening, must reach suppression
With the resultant effect blocking atopic reaction, convergence, removing heat from blood, calmness, removing toxic substances, antiinflammatory.
It is an object of the invention to provide one kind treats allergic rhinitises medicament.
The object of the present invention is achieved like this.
A kind of preparation method treating allergic rhinitises medicament, is made up of following preparation process:
(1) fresh Aquilaria sinensis leaveves 10g and fresh Radix Urenae Lobatae herb 10g clear water are rinsed well, put into microwave-oven-heating so as to
Moisture rapid evaporation, reaches the effect completing, and during to water content 1~3%, takes out, is ground into middle powder;
(2) Cortex Phellodendri 5g is ground into coarse powder, with rice wine 5g infiltration, 150~155 DEG C of parch 3~5min;
(3) Cortex Moutan 5g boiling water is got express developed totally, 85 DEG C of drying, it is ground into coarse powder;
(4) by the whole raw material mixing obtained by above-mentioned steps (1), (2), (3), obtain mixed material, be placed with lid
In glass container, add 3 times of mixed material weight ethanol, concentration of alcohol be 70% (V/V), airtight, at room temperature dipping 3~
5 days, in dipping process, shaking 2 times daily, through 200 mesh centrifugal filtrations, obtained alcohol dipping liquid, obtain alcohol extraction after Distillation recovery ethanol
Taking liquid;
(5) by step (4) after 200 mesh centrifugal filtrations gained medicinal residues add 3 times of medicinal residues weight deionized water, plus
Heat is boiled, and collects distillate 30min with distilling apparatus, obtains distillation medicinal liquid, filters boiling medicinal liquid containing medicinal residues through 200 mesh centrifugations
After medicinal residues, obtain water extraction liquid, add trehalose 2g in water extraction liquid, stir to dissolving, heating evaporation is concentrated into 30g,
Obtain concentrated medicament;
(6) by the prepared alcohol extraction taking liquid of step (4), the distillation medicinal liquid being obtained and concentrated medicament mix with step (5), stir
Mix uniformly, with the glass ampule embedding of 20mL specification, 100 DEG C of 45min sterilizings, prepared one kind treats allergic rhinitises medicament.
The using method of above-mentioned prepared medicament, has following four using method:
(1) by direct for medicament collunarium;
(2) dip in suction medicament with absorbent cotton wool, alternately put in the nostril of left and right;
(3) will spray into after medicament aerosol apparatus or soniclizer atomization or import in nose;
(4) medicament being configured to liposome medicinal liquid successor meaning selects one of above-mentioned three kinds of usings method method to use.
Beneficial effects of the present invention are as follows:
(1) fresh Aquilaria sinensis leaveves, are the fresh leaveves that thymelaeceae Lignum Aquilariae Resinatum belongs to magaphanerophytes' Aquilaria sinensis.Fresh Radix Urenae Lobatae herb, in being
Medical herbs.By the quick heating to fresh Aquilaria sinensis leaveves and fresh Radix Urenae Lobatae for the microwave oven, because microwave heating can produce from the inside of raw material
Heat, therefore moisture energy rapid evaporation, simultaneously by the herbaceous taste in leaveves quickly with vapor evolution, add high heat effect, and complete effect
Fruit highly significant, also acts as sterilization functions.
(2) Cortex Phellodendri, is Chinese crude drug, and bitter in the mouth is cold in nature, by pulverizing, plus rice wine infiltrates and 150~155 DEG C of parches 3~
5min, can significantly reduce the cold of Cortex Phellodendri, reach modified purpose, create condition for cooperation prescription medicine.
(3) Cortex Moutan boiling water is got express developed, can greatly reduce antibacterial and impurity, dries both property of traditional Chineses without prejudice for 85 DEG C,
Can sterilize further again and be conducive to pulverize.
(4) raw material of above-mentioned preliminary treatment is passed through the alcohol dipping of 70% (V/V) concentration, by the alcohol in prescription raw material
Dissolubility functional activity material is leached out, and medicinal residues add water and boil distillation, extracts volatility functional mass, will boil simultaneously and carry medicinal liquid
Filter, concentrate, obtain water-solubility function active substance, by three kinds of different extracting modes, comprehensively fully extract raw material
All effective ingredient.
(5) add trehalose to mix concentration with water extraction liquid, then mix with distillation medicinal liquid and alcohol extraction taking liquid, embedding is gone out
Bacterium, can make the functional activity material in medicinal liquid be protected to greatest extent.
(6) each of prescription of the present invention raw material, tests prove that, nasal mucosa all not only will not be stimulated to produce allergic effect
Reaction, can effectively suppress allergic effect to react on the contrary, wherein, fresh Aquilaria sinensis leaf slightly warm in nature, can tranquillizing and allaying excitement suppression allergic effect reaction;Cortex Phellodendri wine
Cold nature after system, can dehumidify, invigorate blood circulation, antiinflammatory, repair damaged cell;Cortex Moutan energy removing heat from blood, promoting blood circulation, antiinflammatory, suppression allergic effect reaction;Fresh
Radix Urenae Lobatae herb sweet in the mouth, light, mild-natured, enter the heart, lung meridian, can expelling wind and removing dampness, heat-clearing and toxic substances removing, elimination edema.Above-mentioned four Chinese medicine thing is former
After material combination, no acidity penetrating odor, sweet in the mouth, hardship and gas perfume (or spice) is refined, create gentle wind-dispelling, antipruritic, dampness removing consumer edema, disappear
The resultant effect reacting except inflammatory symptoms, calm convergence, suppression allergic effect, prescription is simplified and effect highly significant.
(7) trehalose in playing protection medicinal liquid while functional activity material moreover it is possible to strengthen medicine and nasal mucosa cell
Affinity, also, because it defines one layer of micro- coating function to drug molecule, play the slow releasing function of regulating medicine, this
Effect creates following beneficial effect:1. make that medicine is a small amount of, constant, constantly absorbed by nasal mucosa cell, will not be because of mucosa
Cell instantaneous touch high concentration medicine and cause irritant reaction;2. make medication constant, persistently discharge, persistent is stable.
(8), after adding trehalose, when being fabricated to liposome medicinal liquid, envelop rate can be made to greatly improve, so that medicament is sent out
Wave more preferable curative effect.
(9) common such a phenomenon in clinic, if apply pungent to red, swollen, hot, pain the positive sore patient of trouble
Hot herbal mediciment, can the phenomenon that red, swollen, hot, pain symptoms substantially increase quickly in patient, if use bitter cold instead at once
Removing heat from blood, removing toxic substances, the Chinese herbal medicine of heat clearing away, patient's horse back has refrigerant comfortable sensation it is seen then that the affinity of the property of medicine of medicine, human body
And adaptability is extremely important and significant although current science remains difficult to make detailed explanation, but its mechanism must be
Exist.The prescription of the present invention, is to inspire by the theory of Chinese medicine, searches out and make nasal mucosa have good affinity, adaptability, phase
The medicine of melting property is combined, and its effect can shield resistance sensitinogen, suppression allergic effect reaction, restrains inflammatory reaction symptom, after use, meeting
Feel comfortable immediately, the red and swollen hyperemia prompt resolution of nasal mucosa.From this phenomenon, also disclose an important proposition for us:Right
The understanding of Chinese medicine mechanism and probing into still shoulders heavy responsibilities!But also it is inexhaustible medical science source.
(10) after using the medicament of the present invention, either allergic rhinitises or vasomotor rhinitiies, sneeze, stream are clear
Tears, nasal obstruction symptom can significantly improve, and reached the purpose of " stopping loss " first, thus allowing patient body slowly be recovered strong
Strong, healthy, endocrine recovers normal, and immunity improves, and the adaptability of body strengthens, then, along with benefiting of this medicament
Effect, nasal mucosa functional statuses can be repaired and fully recover, if coordinating Chinese medicine for oral administration conditioning and strengthening body kinematicses, BIYANKANG
Complex velocity is faster.Because continuous clear nasal discharge, it is substantially excessive secretion, that is, a kind of consumption, healthy energy, energy can be made continuous
Loss, therefore, as long as the allergic effect reaction of nose can be pacified, be restrained, can be only achieved the effect stopping loss, thus realizing the mesh of rehabilitation again
, if to be weight lifting light for the effect of the present invention, change numerous to simple.
Specific embodiment
Below by specific embodiment, the invention will be further described.
Embodiment.
A kind of preparation method treating allergic rhinitises medicament, is made up of following preparation process:
(1) fresh Aquilaria sinensis leaveves 10g and fresh Radix Urenae Lobatae herb 10g clear water are rinsed well, put into microwave-oven-heating so as to
Moisture rapid evaporation, reaches the effect completing, and during to water content 1~3%, takes out, is ground into middle powder;
(2) Cortex Phellodendri 5g is ground into coarse powder, with rice wine 5g infiltration, 150~155 DEG C of parch 3~5min;
(3) Cortex Moutan 5g boiling water is got express developed totally, 85 DEG C of drying, it is ground into coarse powder;
(4) by the whole raw material mixing obtained by above-mentioned steps (1), (2), (3), obtain mixed material, be placed with lid
In glass container, add 3 times of mixed material weight ethanol, concentration of alcohol be 70% (V/V), airtight, at room temperature dipping 3~
5 days, in dipping process, shaking 2 times daily, through 200 mesh centrifugal filtrations, obtained alcohol dipping liquid, obtain alcohol extraction after Distillation recovery ethanol
Taking liquid;
(5) by step (4) after 200 mesh centrifugal filtrations gained medicinal residues add 3 times of medicinal residues weight deionized water, plus
Heat is boiled, and collects distillate 30min with distilling apparatus, obtains distillation medicinal liquid, filters boiling medicinal liquid containing medicinal residues through 200 mesh centrifugations
After medicinal residues, obtain water extraction liquid, add trehalose 2g in water extraction liquid, stir to dissolving, heating evaporation is concentrated into 30g,
Obtain concentrated medicament;
(6) by the prepared alcohol extraction taking liquid of step (4), the distillation medicinal liquid being obtained and concentrated medicament mix with step (5), stir
Mix uniformly, with the glass ampule embedding of 20mL specification, 100 DEG C of 45min sterilizings, prepared one kind treats allergic rhinitises medicament.
Application examples 1:Zhang, female, 39 years old, have suffered from allergic rhinitises 6 years, when air quality is slightly worse, frequently play spray
Sneeze, clear nasal discharge, gradually lead to concha swelling, nasal obstruction symptom occurs, feeling of fullness in the head, attention can be caused when serious can not to concentrate, once used
Cross multiple Western medicine kimonos Chinese patent medicine YUPINGFENG SAN, though temporarily can alleviate, can not be restored always, product of the present invention on probation,
With direct collunarium method use, one day drip 4 times, each 3, each left and right nostril, drip after feel comfortable, rhinocnesmus occur without hence it is evident that
Few sneeze, after one month, the symptom of anaphylactic reaction disappears substantially, then adheres to fully recovering using after 2 months, does not have over the past half year
There is recurrence.
Application examples 2:Chen, man, 52 years old, after every morning gets up, the cold and Warm Changes in Northern of temperature, or the cold water washing one's face, washing one's hands
Stimulate, that is, cause sneeze constantly, nose stream clear water shape tears, lead to nasal obstruction, eyelid edema, use the Chinese and Western drug for treating rhinitis on market, also
It can not be restored.The medicament 50g taking above-described embodiment to be obtained, is added to the glass of the adipose membrane being obtained equipped with 80g by lecithin, cholesterol
In glass bottle, with agitator stirring, make liposome medicinal liquid, spray in nose with aerosol apparatus, once a day, after 6 days, symptom is big
Big improve, no flow clear water shape nasal mucus, be continuing with 12 days, and sentence guizhi decoction and close Yupingfeng prescription decoction, the next day take one,
Take 6 doses, after above-mentioned treatment, all diseases disappear, recovery from illness is paid a return visit after 3 months, no recurred.
Embodiment described above only have expressed the better embodiment of the present invention, and its description is more concrete and detailed, but simultaneously
Therefore the restriction to the scope of the claims of the present invention can not be interpreted as, the protection domain of patent of the present invention with claims is
Accurate.
Claims (3)
1. a kind of preparation method treating allergic rhinitises medicament is it is characterised in that be made up of following preparation process:
(1)Fresh Aquilaria sinensis leaveves 10g and fresh Radix Urenae Lobatae herb 10g clear water are rinsed well, puts into microwave-oven-heating so as to moisture
Rapid evaporation, reaches the effect completing, and during to water content 1~3%, takes out, is ground into middle powder;
(2)Cortex Phellodendri 5g is ground into coarse powder, with rice wine 5g infiltration, 150~155 DEG C of parch 3~5min;
(3)Cortex Moutan 5g boiling water is got express developed totally, 85 DEG C of drying, it is ground into coarse powder;
(4)By above-mentioned steps(1)、(2)、(3)Obtained whole raw material mixing, obtain mixed material, are placed with the glass of lid
In container, add the ethanol of 3 times of mixed material weight, concentration of alcohol is 70%(V/V), airtight, impregnate 3~5 days at room temperature,
In dipping process, shaking 2 times daily, through 200 mesh centrifugal filtrations, obtain alcohol dipping liquid, obtain alcohol extraction and get it filled after Distillation recovery ethanol
Liquid;
(5)By step(4)The medicinal residues of middle gained after 200 mesh centrifugal filtrations add the deionized water of 3 times of medicinal residues weight, and heating is boiled
Boiling, collects distillate 30min with distilling apparatus, obtains distillation medicinal liquid, filters medicinal residues by boiling medicinal liquid containing medicinal residues through 200 mesh centrifugations
Afterwards, obtain water extraction liquid, add trehalose 2g in water extraction liquid, stir to dissolving, heating evaporation is concentrated into 30g, obtain dense
Contracting medicinal liquid;
(6)By step(4)Prepared alcohol extraction taking liquid and step(5)Prepared distillation medicinal liquid and concentrated medicament mixing, stirring is all
Even, with the glass ampule embedding of 20mL specification, 100 DEG C of 45min sterilizings, prepared one kind treats allergic rhinitises medicament.
2. the treatment allergic rhinitises medicament that a kind of preparation method as claimed in claim 1 prepares.
3. the using method for the treatment of allergic rhinitises medicament according to claim 2, has following four using method:
(1)By direct for medicament collunarium;
(2)Dip in suction medicament with absorbent cotton wool, alternately put in the nostril of left and right;
(3)To spray into after medicament aerosol apparatus or soniclizer atomization or import in nose;
(4)Medicament is configured to liposome medicinal liquid successor meaning selects one of above-mentioned three kinds of usings method method to use.
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102872169A (en) * | 2012-10-19 | 2013-01-16 | 黄庆德 | Medicine composition for treating chronic rhinitis and preparation method of medicine composition |
CN104940727A (en) * | 2015-07-07 | 2015-09-30 | 王睿超 | Paste for treating rhinitis and preparation method thereof |
CN104957305A (en) * | 2015-07-13 | 2015-10-07 | 陈树杰 | Ficus hispida fruit compounded tea tablets capable of reducing blood glucose and preparation method for ficus hispida fruit compounded tea tablet |
-
2016
- 2016-12-22 CN CN201611195353.7A patent/CN106421155B/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102872169A (en) * | 2012-10-19 | 2013-01-16 | 黄庆德 | Medicine composition for treating chronic rhinitis and preparation method of medicine composition |
CN104940727A (en) * | 2015-07-07 | 2015-09-30 | 王睿超 | Paste for treating rhinitis and preparation method thereof |
CN104957305A (en) * | 2015-07-13 | 2015-10-07 | 陈树杰 | Ficus hispida fruit compounded tea tablets capable of reducing blood glucose and preparation method for ficus hispida fruit compounded tea tablet |
Non-Patent Citations (4)
Title |
---|
冯彬彬: "《中药药理与应用》", 30 November 2015, 中国中医药出版社 * |
周祯祥等: "《张仲景药物学》", 31 January 2012, 中国医药科技出版社 * |
杨懋勋等: ""野生白木香叶化学成分研究"", 《中草药》 * |
王岁楼: "《食品生物技术》", 30 September 1998, 海洋出版社 * |
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