CN106421155A - Drug for treating allergic rhinitis - Google Patents

Drug for treating allergic rhinitis Download PDF

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CN106421155A
CN106421155A CN201611195353.7A CN201611195353A CN106421155A CN 106421155 A CN106421155 A CN 106421155A CN 201611195353 A CN201611195353 A CN 201611195353A CN 106421155 A CN106421155 A CN 106421155A
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water
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CN106421155B (en
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陈树杰
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Suzhou Zhishi Biotechnology Co ltd
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Dongguan Mengchuang Health-Care Technology Co Ltd
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
    • A61K36/835—Aquilaria
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to a drug for treating allergic rhinitis. The drug is prepared through fixing, frying, grinding, ethanol extracting, distillation extracting, decoction extracting, concentration, mixing, encapsulating and sterilizing of 10g of fresh leaves of aquilaria sinensis, 10g of fresh urena lobata herbs, 5g of cortex phellodendri, 5g of cortex moutan and 2g of trehalose. The obtained drug can be made into lipidosome liquid. A user can drip the drug into the nose, dips absorbent cotton in the drug and plugs the absorbent cotton into the nose, or guides the drug through atomization, so that anaphylactic reactions can be removed quickly, and curative effect can be achieved.

Description

One kind treats allergic rhinitises medicament
Technical field
The invention belongs to pharmaceutical technology field, treat allergic rhinitises medicament particularly to one kind.
Background technology
Allergic rhinitises, i.e. allergic rhinitis, refer to the medium that atopic individuals are mainly mediated after contacting allergen by lgE (mainly histamine) discharges, and has the nasal mucosa non-infectious inflammatory disease of the participations such as panimmunity competent cell and cytokine Disease.Also has a kind of cacorhinia, modern medicine is referred to as vasomotor rhinitiies, and its symptom is also much like with allergic rhinitises, also has Typical clear nasal discharge and sneeze, but its mechanism is vegetative nerve, endocrine adjusts not normal drawing to the blood vessel of nasal mucosa, Intervention Rise.
Although modern medicine can explain the pathogeny of above-mentioned rhinitis in more detail, also can adopt for different pathological types Obtain certain curative effect with the corresponding Drug therapy such as such as antihistamine, glucocorticoid, anticholinergic, but all cannot thoroughly control Heal, and large side effects.
The traditional Chinese medical science just had discussion primary disease, referred to as allergic rhinitis, nasal sinusitis before thousand of years, in the successive dynasties doctor also develop many Treatment prescription and method, the such as guizhi decoction of warming lung for dispelling cold and Ephedrae Decoction, the YUPINGFENG SAN of benefiting QI for strengthening the superficies, the benefit of replenishing QI to invigorate the spleen yang invigorating Middle Qi-benefiting decoction, the Zhen Wu Tang, Decoction for strengthening the Spleen-Yang of warming YANG to promote diuresis, the Lonicerae and Forsythiae Powder of wind-dispelling heat-dissipating, and various external pulvis and drip, wash Chinese medicine, can not Deny, it also can produce effects in terms of improving body constitution and mitigation symptoms, but anaphylactoid many symptoms of nose still cannot Eradicate, be difficult to cure.
Content of the invention
The present inventor, by carrying out in-depth study to the rhinitis of similar allergic rhinitis symptoms, is closed in conjunction with to of all times Analysis in the discussion of such disease finds, the immunocompetence of human body and primary disease are the relations having reciprocal causation, Wo Mentong Often only emphasize due to the immunity of human body not strong, primary disease just can occur, but not pay attention to the symptom that primary disease long-term morbidity occurs Itself, the immunity that also can make us body is constantly impaired, and yang-energy cannot be restrained rehabilitation, defines vicious cycle.Understand This point, just should crucial focus on the local route repair of nasal mucosa, in the appearance that prevents from induce ill symptom, to patient Obtain the time of rehabilitation, because human body is the self-rehabilitation ability with mystery in itself, as long as can give body good propping up Hold and the time, need not be using excessive Drug therapy, the rehabilitation instinct of human body is can to realize fully recovering completely.However, making a general survey of Treat the medication of above-mentioned rhinitis, the blocker of Western medicine, Claritin, hormone, or even the abuse of antibiotic at all times, all repeatedly Disturb the ecological environment of nose.Even the traditional Chinese medical science, also commonly use such as Herba Pogostemoniss, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Xin Maihua, Borneolum Syntheticum, Herba Schizonepetae, fiber crops The stimulating drug of the acidities such as Huang, Fructus Xanthii, Fructus Foeniculi, defends tenaciously the theory medication of wind dispelling cold expelling, and result is so that nasal mucosa is subject to Stimulation repeatedly, not only can not effect a radical cure allergic rhinitises, so that the touching difficulty of the state of an illness is healed on the contrary, this kind of topical agent is in the patent literature Also can be found everywhere, really regrettable.
Inventors believe that, no matter being the medium release that allergen causes, or nerve, endocrine to the blood vessel of nasal mucosa, Intervention adjust not normal, all related to the stimulation that nasal mucosa cell is subject to, the present invention has screened substantial amounts of Chinese herbal medicine, with sweet, Light, amara is drug choice, avoids dripping of irritant drugs first, then from the property of medicine, functionally test and screening, must reach suppression With the resultant effect blocking atopic reaction, convergence, removing heat from blood, calmness, removing toxic substances, antiinflammatory.
It is an object of the invention to provide one kind treats allergic rhinitises medicament.
The object of the present invention is achieved like this.
A kind of preparation method treating allergic rhinitises medicament, is made up of following preparation process：
(1) fresh Aquilaria sinensis leaveves 10g and fresh Radix Urenae Lobatae herb 10g clear water are rinsed well, put into microwave-oven-heating so as to Moisture rapid evaporation, reaches the effect completing, and during to water content 1～3%, takes out, is ground into middle powder；
(2) Cortex Phellodendri 5g is ground into coarse powder, with rice wine 5g infiltration, 150～155 DEG C of parch 3～5min；
(3) Cortex Moutan 5g boiling water is got express developed totally, 85 DEG C of drying, it is ground into coarse powder；
(4) by the whole raw material mixing obtained by above-mentioned steps (1), (2), (3), obtain mixed material, be placed with lid In glass container, add 3 times of mixed material weight ethanol, concentration of alcohol be 70% (V/V), airtight, at room temperature dipping 3～ 5 days, in dipping process, shaking 2 times daily, through 200 mesh centrifugal filtrations, obtained alcohol dipping liquid, obtain alcohol extraction after Distillation recovery ethanol Taking liquid；
(5) by step (4) after 200 mesh centrifugal filtrations gained medicinal residues add 3 times of medicinal residues weight deionized water, plus Heat is boiled, and collects distillate 30min with distilling apparatus, obtains distillation medicinal liquid, filters boiling medicinal liquid containing medicinal residues through 200 mesh centrifugations After medicinal residues, obtain water extraction liquid, add trehalose 2g in water extraction liquid, stir to dissolving, heating evaporation is concentrated into 30g, Obtain concentrated medicament；
(6) by the prepared alcohol extraction taking liquid of step (4), the distillation medicinal liquid being obtained and concentrated medicament mix with step (5), stir Mix uniformly, with the glass ampule embedding of 20mL specification, 100 DEG C of 45min sterilizings, prepared one kind treats allergic rhinitises medicament.
The using method of above-mentioned prepared medicament, has following four using method：
(1) by direct for medicament collunarium；
(2) dip in suction medicament with absorbent cotton wool, alternately put in the nostril of left and right；
(3) will spray into after medicament aerosol apparatus or soniclizer atomization or import in nose；
(4) medicament being configured to liposome medicinal liquid successor meaning selects one of above-mentioned three kinds of usings method method to use.
Beneficial effects of the present invention are as follows：
(1) fresh Aquilaria sinensis leaveves, are the fresh leaveves that thymelaeceae Lignum Aquilariae Resinatum belongs to magaphanerophytes' Aquilaria sinensis.Fresh Radix Urenae Lobatae herb, in being Medical herbs.By the quick heating to fresh Aquilaria sinensis leaveves and fresh Radix Urenae Lobatae for the microwave oven, because microwave heating can produce from the inside of raw material Heat, therefore moisture energy rapid evaporation, simultaneously by the herbaceous taste in leaveves quickly with vapor evolution, add high heat effect, and complete effect Fruit highly significant, also acts as sterilization functions.
(2) Cortex Phellodendri, is Chinese crude drug, and bitter in the mouth is cold in nature, by pulverizing, plus rice wine infiltrates and 150～155 DEG C of parches 3～ 5min, can significantly reduce the cold of Cortex Phellodendri, reach modified purpose, create condition for cooperation prescription medicine.
(3) Cortex Moutan boiling water is got express developed, can greatly reduce antibacterial and impurity, dries both property of traditional Chineses without prejudice for 85 DEG C, Can sterilize further again and be conducive to pulverize.
(4) raw material of above-mentioned preliminary treatment is passed through the alcohol dipping of 70% (V/V) concentration, by the alcohol in prescription raw material Dissolubility functional activity material is leached out, and medicinal residues add water and boil distillation, extracts volatility functional mass, will boil simultaneously and carry medicinal liquid Filter, concentrate, obtain water-solubility function active substance, by three kinds of different extracting modes, comprehensively fully extract raw material All effective ingredient.
(5) add trehalose to mix concentration with water extraction liquid, then mix with distillation medicinal liquid and alcohol extraction taking liquid, embedding is gone out Bacterium, can make the functional activity material in medicinal liquid be protected to greatest extent.
(6) each of prescription of the present invention raw material, tests prove that, nasal mucosa all not only will not be stimulated to produce allergic effect Reaction, can effectively suppress allergic effect to react on the contrary, wherein, fresh Aquilaria sinensis leaf slightly warm in nature, can tranquillizing and allaying excitement suppression allergic effect reaction；Cortex Phellodendri wine Cold nature after system, can dehumidify, invigorate blood circulation, antiinflammatory, repair damaged cell；Cortex Moutan energy removing heat from blood, promoting blood circulation, antiinflammatory, suppression allergic effect reaction；Fresh Radix Urenae Lobatae herb sweet in the mouth, light, mild-natured, enter the heart, lung meridian, can expelling wind and removing dampness, heat-clearing and toxic substances removing, elimination edema.Above-mentioned four Chinese medicine thing is former After material combination, no acidity penetrating odor, sweet in the mouth, hardship and gas perfume (or spice) is refined, create gentle wind-dispelling, antipruritic, dampness removing consumer edema, disappear The resultant effect reacting except inflammatory symptoms, calm convergence, suppression allergic effect, prescription is simplified and effect highly significant.
(7) trehalose in playing protection medicinal liquid while functional activity material moreover it is possible to strengthen medicine and nasal mucosa cell Affinity, also, because it defines one layer of micro- coating function to drug molecule, play the slow releasing function of regulating medicine, this Effect creates following beneficial effect：1. make that medicine is a small amount of, constant, constantly absorbed by nasal mucosa cell, will not be because of mucosa Cell instantaneous touch high concentration medicine and cause irritant reaction；2. make medication constant, persistently discharge, persistent is stable.
(8), after adding trehalose, when being fabricated to liposome medicinal liquid, envelop rate can be made to greatly improve, so that medicament is sent out Wave more preferable curative effect.
(9) common such a phenomenon in clinic, if apply pungent to red, swollen, hot, pain the positive sore patient of trouble Hot herbal mediciment, can the phenomenon that red, swollen, hot, pain symptoms substantially increase quickly in patient, if use bitter cold instead at once Removing heat from blood, removing toxic substances, the Chinese herbal medicine of heat clearing away, patient's horse back has refrigerant comfortable sensation it is seen then that the affinity of the property of medicine of medicine, human body And adaptability is extremely important and significant although current science remains difficult to make detailed explanation, but its mechanism must be Exist.The prescription of the present invention, is to inspire by the theory of Chinese medicine, searches out and make nasal mucosa have good affinity, adaptability, phase The medicine of melting property is combined, and its effect can shield resistance sensitinogen, suppression allergic effect reaction, restrains inflammatory reaction symptom, after use, meeting Feel comfortable immediately, the red and swollen hyperemia prompt resolution of nasal mucosa.From this phenomenon, also disclose an important proposition for us：Right The understanding of Chinese medicine mechanism and probing into still shoulders heavy responsibilities！But also it is inexhaustible medical science source.
(10) after using the medicament of the present invention, either allergic rhinitises or vasomotor rhinitiies, sneeze, stream are clear Tears, nasal obstruction symptom can significantly improve, and reached the purpose of " stopping loss " first, thus allowing patient body slowly be recovered strong Strong, healthy, endocrine recovers normal, and immunity improves, and the adaptability of body strengthens, then, along with benefiting of this medicament Effect, nasal mucosa functional statuses can be repaired and fully recover, if coordinating Chinese medicine for oral administration conditioning and strengthening body kinematicses, BIYANKANG Complex velocity is faster.Because continuous clear nasal discharge, it is substantially excessive secretion, that is, a kind of consumption, healthy energy, energy can be made continuous Loss, therefore, as long as the allergic effect reaction of nose can be pacified, be restrained, can be only achieved the effect stopping loss, thus realizing the mesh of rehabilitation again , if to be weight lifting light for the effect of the present invention, change numerous to simple.
Specific embodiment
Below by specific embodiment, the invention will be further described.
Embodiment.
A kind of preparation method treating allergic rhinitises medicament, is made up of following preparation process：
(1) fresh Aquilaria sinensis leaveves 10g and fresh Radix Urenae Lobatae herb 10g clear water are rinsed well, put into microwave-oven-heating so as to Moisture rapid evaporation, reaches the effect completing, and during to water content 1～3%, takes out, is ground into middle powder；
(2) Cortex Phellodendri 5g is ground into coarse powder, with rice wine 5g infiltration, 150～155 DEG C of parch 3～5min；
(3) Cortex Moutan 5g boiling water is got express developed totally, 85 DEG C of drying, it is ground into coarse powder；
(4) by the whole raw material mixing obtained by above-mentioned steps (1), (2), (3), obtain mixed material, be placed with lid In glass container, add 3 times of mixed material weight ethanol, concentration of alcohol be 70% (V/V), airtight, at room temperature dipping 3～ 5 days, in dipping process, shaking 2 times daily, through 200 mesh centrifugal filtrations, obtained alcohol dipping liquid, obtain alcohol extraction after Distillation recovery ethanol Taking liquid；
(5) by step (4) after 200 mesh centrifugal filtrations gained medicinal residues add 3 times of medicinal residues weight deionized water, plus Heat is boiled, and collects distillate 30min with distilling apparatus, obtains distillation medicinal liquid, filters boiling medicinal liquid containing medicinal residues through 200 mesh centrifugations After medicinal residues, obtain water extraction liquid, add trehalose 2g in water extraction liquid, stir to dissolving, heating evaporation is concentrated into 30g, Obtain concentrated medicament；
(6) by the prepared alcohol extraction taking liquid of step (4), the distillation medicinal liquid being obtained and concentrated medicament mix with step (5), stir Mix uniformly, with the glass ampule embedding of 20mL specification, 100 DEG C of 45min sterilizings, prepared one kind treats allergic rhinitises medicament.
Application examples 1：Zhang, female, 39 years old, have suffered from allergic rhinitises 6 years, when air quality is slightly worse, frequently play spray Sneeze, clear nasal discharge, gradually lead to concha swelling, nasal obstruction symptom occurs, feeling of fullness in the head, attention can be caused when serious can not to concentrate, once used Cross multiple Western medicine kimonos Chinese patent medicine YUPINGFENG SAN, though temporarily can alleviate, can not be restored always, product of the present invention on probation, With direct collunarium method use, one day drip 4 times, each 3, each left and right nostril, drip after feel comfortable, rhinocnesmus occur without hence it is evident that Few sneeze, after one month, the symptom of anaphylactic reaction disappears substantially, then adheres to fully recovering using after 2 months, does not have over the past half year There is recurrence.
Application examples 2：Chen, man, 52 years old, after every morning gets up, the cold and Warm Changes in Northern of temperature, or the cold water washing one's face, washing one's hands Stimulate, that is, cause sneeze constantly, nose stream clear water shape tears, lead to nasal obstruction, eyelid edema, use the Chinese and Western drug for treating rhinitis on market, also It can not be restored.The medicament 50g taking above-described embodiment to be obtained, is added to the glass of the adipose membrane being obtained equipped with 80g by lecithin, cholesterol In glass bottle, with agitator stirring, make liposome medicinal liquid, spray in nose with aerosol apparatus, once a day, after 6 days, symptom is big Big improve, no flow clear water shape nasal mucus, be continuing with 12 days, and sentence guizhi decoction and close Yupingfeng prescription decoction, the next day take one, Take 6 doses, after above-mentioned treatment, all diseases disappear, recovery from illness is paid a return visit after 3 months, no recurred.
Embodiment described above only have expressed the better embodiment of the present invention, and its description is more concrete and detailed, but simultaneously Therefore the restriction to the scope of the claims of the present invention can not be interpreted as, the protection domain of patent of the present invention with claims is Accurate.

Claims (3)

1. a kind of preparation method treating allergic rhinitises medicament is it is characterised in that be made up of following preparation process：
（1）Fresh Aquilaria sinensis leaveves 10g and fresh Radix Urenae Lobatae herb 10g clear water are rinsed well, puts into microwave-oven-heating so as to moisture Rapid evaporation, reaches the effect completing, and during to water content 1～3%, takes out, is ground into middle powder；
（2）Cortex Phellodendri 5g is ground into coarse powder, with rice wine 5g infiltration, 150～155 DEG C of parch 3～5min；
（3）Cortex Moutan 5g boiling water is got express developed totally, 85 DEG C of drying, it is ground into coarse powder；
（4）By above-mentioned steps（1）、（2）、（3）Obtained whole raw material mixing, obtain mixed material, are placed with the glass of lid In container, add the ethanol of 3 times of mixed material weight, concentration of alcohol is 70%（V/V）, airtight, impregnate 3～5 days at room temperature, In dipping process, shaking 2 times daily, through 200 mesh centrifugal filtrations, obtain alcohol dipping liquid, obtain alcohol extraction and get it filled after Distillation recovery ethanol Liquid；
（5）By step（4）The medicinal residues of middle gained after 200 mesh centrifugal filtrations add the deionized water of 3 times of medicinal residues weight, and heating is boiled Boiling, collects distillate 30min with distilling apparatus, obtains distillation medicinal liquid, filters medicinal residues by boiling medicinal liquid containing medicinal residues through 200 mesh centrifugations Afterwards, obtain water extraction liquid, add trehalose 2g in water extraction liquid, stir to dissolving, heating evaporation is concentrated into 30g, obtain dense Contracting medicinal liquid；
（6）By step（4）Prepared alcohol extraction taking liquid and step（5）Prepared distillation medicinal liquid and concentrated medicament mixing, stirring is all Even, with the glass ampule embedding of 20mL specification, 100 DEG C of 45min sterilizings, prepared one kind treats allergic rhinitises medicament.
2. the treatment allergic rhinitises medicament that a kind of preparation method as claimed in claim 1 prepares.
3. the using method for the treatment of allergic rhinitises medicament according to claim 2, has following four using method：
（1）By direct for medicament collunarium；
（2）Dip in suction medicament with absorbent cotton wool, alternately put in the nostril of left and right；
（3）To spray into after medicament aerosol apparatus or soniclizer atomization or import in nose；
（4）Medicament is configured to liposome medicinal liquid successor meaning selects one of above-mentioned three kinds of usings method method to use.
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102872169A (en) * 2012-10-19 2013-01-16 黄庆德 Medicine composition for treating chronic rhinitis and preparation method of medicine composition
CN104940727A (en) * 2015-07-07 2015-09-30 王睿超 Paste for treating rhinitis and preparation method thereof
CN104957305A (en) * 2015-07-13 2015-10-07 陈树杰 Ficus hispida fruit compounded tea tablets capable of reducing blood glucose and preparation method for ficus hispida fruit compounded tea tablet

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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