CN106421085A - Paulownia flower-containing pharmaceutical composition for treating animal viral infectious diseases - Google Patents
Paulownia flower-containing pharmaceutical composition for treating animal viral infectious diseases Download PDFInfo
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- CN106421085A CN106421085A CN201610955259.0A CN201610955259A CN106421085A CN 106421085 A CN106421085 A CN 106421085A CN 201610955259 A CN201610955259 A CN 201610955259A CN 106421085 A CN106421085 A CN 106421085A
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- pharmaceutical composition
- honeysuckle
- paulownia flower
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
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- Biotechnology (AREA)
- Botany (AREA)
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- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a paulownia flower-containing pharmaceutical composition for treating animal viral infectious diseases. The pharmaceutical composition is a preparation prepared by taking honeysuckle and paulownia flower as raw materials. The invention further discloses a preparation method and use of the pharmaceutical composition. By combining the honeysuckle with the paulownia flower for use, the pharmaceutical composition has a good effect for treating the animal viral infectious diseases as well as a pharmacodynamics activity obviously higher than the pharmacodynamics activities of the single honeysuckle and the single paulownia flower and plays a role of synergistic interaction; and meanwhile, medicines in a prescription are few, the cost is relatively low, and the clinical application prospect is excellent.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of animal virus sexually transmitted disease comprising fortune paulownia flower and its preparation side
Method and purposes.
Background technology
Animal virus sexually transmitted disease is the modal disease of plant, and including swine fever, pig epidemic diarrhea etc., poultry is infected
Property bronchitis, gumboro disease, chicken Marek's disease, newcastle disease and bird flu etc., this kind of disease has mostly
Very strong infectiousness, leads to the large-area infection of plant, morbidity or even death after morbidity, causes to plant huge
Loss.
Pig epidemic diarrhea (PED) is a kind of pig enteric infectious disease being caused by Porcine epidemic diarrhea virus (PEDV), pig
Transmissible gastroenteritis (TGE) is a kind of height being caused by coronaviridae coronavirus genus transmissible gastro-enteritis virus (TGEV)
The viral disease of degree contagiousness.Two viral diseases are all mainly characterized with vomiting, diarrhoea and dehydration, each age group
Pig all can occur, and the incidence of disease reaches as high as 100%, and suckling pig is aggrieved the most serious, and pig epidemic diarrhea was in 70 years 20th century
Find this disease for first Britain first, the state such as subsequently Belgian, Canadian, Japanese, German, French also occurs and reports PED's
Popular, China starts the report just having this disease from early 1980s.
Bursal Disease (Infectious bursal disease, IBD) is by infectious bursal disease virus
The inhibitive ability of immunity of a kind of serious harm chick that (Infectious bursal disease virus, IBDV) causes, highly
Contagious disease.This sick feature is that the incidence of disease is high, the course of disease is short, impact chicken house production performance and cause direct economic loss, with
When may result in immunosupress, make chicken that the immune response of multiple vaccines is declined, causes immuning failure, so that chicken group is to other diseases
The neurological susceptibility of substance increases.
At present using vaccine immunization, interferon, immunoglobulin (Ig), immune core more than the treatment of animal virus sexually transmitted disease
The biochemical drugs such as ribosomal ribonucleic acid are treated, and there is price costly, the shortcomings of curative effect is notable, a large amount of uses of antibiotic,
It is likely to result in livestock and poultry and produces drug resistance, be further exacerbated by scabies secondary infection.
Honeysuckle is dry flower or the first flower opened of band of caprifoliaceae plant honeysuckle Lonicera japonica Thunb..
The flowers are in blossom puts front harvesting for early summer, is dried.【Nature and flavor and return through】Sweet, tremble with fear.Return lung, the heart, stomach.【Function with cure mainly】Clearing heat and detoxicating, dredge
Dissipate wind-heat.For carbuncle swells furunculosis, larynx numbness, erysipelas, toxic-heat and blood stasis, anemopyretic cold, warm disease heating.
Fortune paulownia flower is goatweed Paulownia elongata (Paulownia elongata S.Y.Hu) or belongs to several plants together
Flower is dried.Harvesting when spring flower falls, removes impurity, is dried.It is born in hillside, Lin Zhong, mountain valley and wasteland, the wild or cultivation of low altitude area
Training.Paulownia are distributed in each province on the south the Changjiang river, the ground such as Shaanxi, Shandong, south of the River introducing and planting.Bitter, cold in nature.Have removing heat from the lung and relieving sorethroat,
The effects such as removing toxicity for detumescence.Cure mainly cough with lung heat, acute tonsillitis, bacillary dysentery, chordapsus, acute conjunctivitis, parotitis, furuncle
The diseases such as swollen, sore tinea.
At present, have no the report that honeysuckle and fortune paulownia flower are individually applied in combination.
Content of the invention
For solving the above problems, the invention provides a kind of medicine of the treatment animal virus sexually transmitted disease comprising fortune paulownia flower
Composition, it is the preparation being prepared from for bulk drug by honeysuckle and fortune paulownia flower.
Further, described honeysuckle and the weight ratio of fortune paulownia flower are 2:1～1:2.
Further, described honeysuckle and the weight ratio of fortune paulownia flower are 2:1.
Further, it be by the medicinal powder of bulk drug, the water of bulk drug or extractive with organic solvent be active component, add
The preparation that in medicine, conventional auxiliary material or complementary composition are prepared from.
Further, described preparation is superfine powder, granule or soluble powder.
Further, the particle diameter of described superfine powder is less than 50 μm.
Present invention also offers a kind of method preparing foregoing pharmaceutical composition, it comprises the steps：
(1) weigh each raw material by weight ratio；
(2) take the medicinal powder of bulk drug or the water of bulk drug or extractive with organic solvent, in dosing product conventional auxiliary material or
Complementary composition is prepared into preparation.
Present invention also offers purposes in the medicine of preparation treatment animal virus sexually transmitted disease for the foregoing pharmaceutical composition.
Further, described animal is poultry or domestic animals animal.
Further, described poultry is chicken, and domestic animals animal is pig.
Further, described animal virus sexually transmitted disease be swine fever, pig epidemic diarrhea, family's avian infectious bronchitis,
Bursal Disease, chicken Marek's disease, newcastle disease or bird flu.
Experiment results proved, the pharmaceutical composition that the present invention provides, honeysuckle and fortune paulownia flower are applied in combination, have good
Treatment animal virus sexually transmitted disease effect, its drug activity is substantially better than alone group of honeysuckle and fortune paulownia flower, serves association
With the effect of synergy, flavour of a drug are less simultaneously, and cost is relatively low, and potential applicability in clinical practice is excellent.
Obviously, the above according to the present invention, according to ordinary technical knowledge and the customary means of this area, without departing from
Under the premise of the present invention above-mentioned basic fundamental thought, modification, replacement or the change of other various ways can also be made.
The specific embodiment of form by the following examples, remakes further specifically to the above of the present invention
Bright.But this scope being interpreted as the above-mentioned theme of the present invention should not be only limitted to Examples below.All based on the above of the present invention
The technology realized belongs to the scope of the present invention.
Specific embodiment
The preparation of embodiment 1 pharmaceutical composition of the present invention
1st, prescription：Honeysuckle 500g, fortune paulownia flower 500g.
2nd, take prescription medicinal material, it is less than 5% that forced air drying makes water content, routine pulverized No. five sieves (80 mesh), obtained medicinal material
Fine powder mixture, mixture is put in micronizer, and under -20 DEG C of cryogenic conditions, ultramicro grinding more than 20 minutes, obtains grain
The Ultramicro-powder that footpath is less than 50 μm.
The preparation of embodiment 2 pharmaceutical composition of the present invention
1st, with honeysuckle：The weight of fortune paulownia flower compares 2:1 as prescription, is easy to operate, actual extracting honeysuckle 667g, paulownia
Flower 333g.
2nd, take prescription medicinal material, it is less than 5% that forced air drying makes water content, routine pulverized No. five sieves (80 mesh), obtained medicinal material
Fine powder mixture, mixture is put in micronizer, and under -20 DEG C of cryogenic conditions, ultramicro grinding more than 20 minutes, obtains grain
The Ultramicro-powder that footpath is less than 50 μm.
The preparation of embodiment 3 pharmaceutical composition of the present invention
1st, with honeysuckle：The weight of fortune paulownia flower compares 1:2 as prescription, is easy to operate, actual extracting honeysuckle 333g, paulownia
Flower 667g.
2nd, take prescription medicinal material, it is less than 5% that forced air drying makes water content, routine pulverized No. five sieves (80 mesh), obtained medicinal material
Fine powder mixture, mixture is put in micronizer, and under -20 DEG C of cryogenic conditions, ultramicro grinding more than 20 minutes, obtains grain
The Ultramicro-powder that footpath is less than 50 μm.
The preparation of embodiment 4 pharmaceutical composition of the present invention
1st, prescription：Honeysuckle 500g, fortune paulownia flower 500g.
2nd, take prescription medicinal material, plus 20 times amount water boiling and extraction be secondary, extract 1 hour every time, decocting liquid filters, filtrate merges,
Be concentrated into the medicinal extract that relative density is 1.15～1.20 (60 DEG C), plus ethanol make alcohol content reach 55%, stirring, standing 24 hours with
On, filtration, filtrate is concentrated into the medicinal extract that relative density is 1.32～1.35 (70 DEG C), plus sugarcane sugar and starch, mixes, and pelletizes, and does
Dry, make 1000g, obtain final product.
The preparation of embodiment 5 pharmaceutical composition of the present invention
1st, prescription：Honeysuckle 500g, fortune paulownia flower 500g.
2nd, take prescription medicinal material, plus 20 times amount water boiling and extraction be secondary, extract 1 hour every time, decocting liquid filters, filtrate merges,
It is concentrated into the medicinal extract that relative density is 1.10～1.12 (60 DEG C), medicinal extract is spray-dried and collects powder, plus dextrin is appropriate extremely
1000g, mixes, obtains final product.
Prove beneficial effects of the present invention below by way of specific experiment.
The therapeutic action to Bursal Disease of experimental example 1 pharmaceutical composition of the present invention
1st, test material
Honeysuckle micro powder sample：Extracting honeysuckle 1000g, prepares micropowder samples as described in Example 1, obtains final product.
Fortune paulownia flower micropowder samples：Take fortune paulownia flower 1000g, prepare micropowder samples as described in Example 1, obtain final product.
Honeysuckle micropowder samples 1：The pharmaceutical composition that embodiment 1 prepares.
Honeysuckle micropowder samples 2：The pharmaceutical composition that embodiment 2 prepares.
Honeysuckle micropowder samples 3：The pharmaceutical composition that embodiment 3 prepares.
Honeysuckle particle：The pharmaceutical composition that embodiment 4 prepares.
Honeysuckle soluble powder：The pharmaceutical composition that embodiment 5 prepares.
2nd, animal used as test selects and is grouped
Choose clinical 3-6 week old, performance spirit is depressed, loss of appetite, feather are fluffy, the white loose stool of row, or even collapse is dead
The symptom such as die, the chicken being diagnosed as gumboro disease, as clinical testing object, 240 altogether, is divided into 8 groups, every group 30.
Normal group is normally raised, and the daily spice of remaining each group gives corresponding drug therapy, and concrete medication is such as
Table 1 below.
Table 1 test packet and administration
3 test indexs and method
During administration and 7 days after the completion of administration, observe clinical symptoms and the Cure of each group illness chicken, system
The indexs such as meter analysis cure rate, the death rate.
4 result of the tests and analysis
The clinical test results to Bursal Disease therapeutic action for table 2 present composition
From clinical verification result of the test, the control group death rate is 60.00%, and the death rate of honeysuckle micro powder group is
43.33%, the death rate of paulownia flower micropowder group is 40.00%.Through Chi-square Test, each composition administration group is compared with control group,
Significant difference (P<0.01), each composition administration group is compared respectively with honeysuckle micro powder group, paulownia flower micropowder group, and difference is all notable
P<0.01), the death rate substantially reduces, and is held in less than 20%, has the significant curative effect treating Bursal Disease.
It can be seen that, after sharing with fortune paulownia flower medicinal material, by suitable prescription proportioning screening, curative effect increases traditional Chinese medicine honeysuckle
By force, better than honeysuckle and fortune paulownia flower single medicinal material, curative effect is administered alone group better than each medicinal material, with the curative effect of 2 groups of honeysuckle micro mist
Excellent, to the cure rate of Bursal Disease up to 93.33%.Therefore, honeysuckle and fortune paulownia flower medicinal material preferably prescription ratio
Example is 2:1.
The therapeutic action to pig epidemic diarrhea for experimental example 2 pharmaceutical composition of the present invention
1 trial drug
Honeysuckle micro powder sample sets：Extracting honeysuckle 1000g, prepares micropowder samples as described in Example 1, obtains final product.
Fortune paulownia flower micropowder samples group：Take fortune paulownia flower 1000g, prepare micropowder samples as described in Example 1, obtain final product.
Honeysuckle micropowder samples：The pharmaceutical composition that embodiment 2 prepares.
2 animals used as test select and are grouped
Choose analysed according to clinical symptoms, pathology, affected pig epidemic diarrhea piglet case that the method such as pathogen separation is made a definite diagnosis
Each 200, it is divided into 4 groups, every group 50, the normal raising of control group is not treated, and the daily spice of remaining each group gives corresponding medicine
Treatment, concrete medication such as table 3 below.
Table 3 test packet and administration
3 results
Result of the test shows, each group medicine is respectively provided with certain therapeutic effect to pig epidemic diarrhea, and clinical cure rate is high
Reach more than 75%.Through Chi-square Test, wherein honeysuckle micro mist group is compared with control group, the extremely notable (P of difference<0.01), honeysuckle micro mist
Group is compared with honeysuckle micro powder group, paulownia flower micropowder group, all notable (P of difference<0.01) it was demonstrated that honeysuckle micro mist group curative effect is best,
The effect using respectively better than honeysuckle and fortune paulownia flower, is also demonstrated further and is being shared with fortune paulownia flower medicinal material when traditional Chinese medicine honeysuckle
(especially honeysuckle afterwards：Fortune paulownia flower=2:When 1), curative effect greatly enhances, better than honeysuckle and fortune paulownia flower single medicinal material, test knot
Fruit see table 4.
The clinical test results to pig epidemic diarrhea for table 4 present composition
In sum, the pharmaceutical composition that the present invention provides, honeysuckle and fortune paulownia flower is applied in combination, has good controlling
Treat animal virus sexually transmitted disease effect, its drug activity is substantially better than alone group of honeysuckle and fortune paulownia flower, serve collaborative increasing
The effect of effect, flavour of a drug are less simultaneously, and cost is relatively low, and potential applicability in clinical practice is excellent.
Claims (10)
1. a kind of comprise fortune paulownia flower treatment animal virus sexually transmitted disease pharmaceutical composition it is characterised in that：It is by gold and silver
The preparation that flower and fortune paulownia flower are prepared from for bulk drug.
2. pharmaceutical composition according to claim 1 it is characterised in that：Described honeysuckle with the weight ratio of fortune paulownia flower is
2:1～1:2.
3. pharmaceutical composition according to claim 2 it is characterised in that：Described honeysuckle with the weight ratio of fortune paulownia flower is
2:1.
4. the pharmaceutical composition according to any one of claim 1-3 it is characterised in that：It is by the medicinal powder, former of bulk drug
The water of material medicine or extractive with organic solvent are active component, add that conventional auxiliary material in medicine or complementary composition are prepared from
Preparation.
5. pharmaceutical composition according to claim 4 it is characterised in that：Described preparation is superfine powder, granule or can
Soluble powder.
6. a kind of method preparing claim 1-5 any one described pharmaceutical composition, it comprises the steps：
(1) weigh each raw material by weight ratio；
(2) medicinal powder of bulk drug or the water of bulk drug or extractive with organic solvent are taken, conventional auxiliary material or auxiliary in dosing product
Property composition is prepared into preparation.
7. use in the medicine of preparation treatment animal virus sexually transmitted disease for any one of the claim 1-5 described pharmaceutical composition
On the way.
8. purposes according to claim 7 it is characterised in that：Described animal is poultry or domestic animals animal.
9. purposes according to claim 8 it is characterised in that：Described poultry is chicken, and domestic animals animal is pig.
10. purposes according to claim 8 it is characterised in that：Described animal virus sexually transmitted disease is swine fever, pig popularity
Diarrhoea, family's avian infectious bronchitis, Bursal Disease, chicken Marek's disease, newcastle disease or bird flu.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610955259.0A CN106421085A (en) | 2016-10-27 | 2016-10-27 | Paulownia flower-containing pharmaceutical composition for treating animal viral infectious diseases |
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| CN201610955259.0A CN106421085A (en) | 2016-10-27 | 2016-10-27 | Paulownia flower-containing pharmaceutical composition for treating animal viral infectious diseases |
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| CN201610955259.0A Pending CN106421085A (en) | 2016-10-27 | 2016-10-27 | Paulownia flower-containing pharmaceutical composition for treating animal viral infectious diseases |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115554347A (en) * | 2022-08-25 | 2023-01-03 | 河南农业大学 | Virus inhibitor and preparation method and application thereof |
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|---|---|---|---|---|
| CN1533784A (en) * | 2003-04-02 | 2004-10-06 | 陈世杰 | Chinese medicinal composition for treating animal virus zymosis |
| CN1907337A (en) * | 2006-08-22 | 2007-02-07 | 天津生机集团有限公司 | Shuanghuanglian oral liquor for fowl and its preparing method |
| CN102988490A (en) * | 2012-11-26 | 2013-03-27 | 河南新正好生物工程有限公司 | Application of Shuanghuanglian oral liquor in preparation of medicine for treating and preventing poultry virosis |
| CN104784327A (en) * | 2015-05-07 | 2015-07-22 | 成都乾坤动物药业有限公司 | Traditional Chinese veterinary medicine composition for treating respiratory diseases of chicken and preparation method thereof |
-
2016
- 2016-10-27 CN CN201610955259.0A patent/CN106421085A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1533784A (en) * | 2003-04-02 | 2004-10-06 | 陈世杰 | Chinese medicinal composition for treating animal virus zymosis |
| CN100384440C (en) * | 2003-04-02 | 2008-04-30 | 陈世杰 | Chinese medicinal composition for treating animal virus zymosis |
| CN1907337A (en) * | 2006-08-22 | 2007-02-07 | 天津生机集团有限公司 | Shuanghuanglian oral liquor for fowl and its preparing method |
| CN102988490A (en) * | 2012-11-26 | 2013-03-27 | 河南新正好生物工程有限公司 | Application of Shuanghuanglian oral liquor in preparation of medicine for treating and preventing poultry virosis |
| CN104784327A (en) * | 2015-05-07 | 2015-07-22 | 成都乾坤动物药业有限公司 | Traditional Chinese veterinary medicine composition for treating respiratory diseases of chicken and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 吴德峰等: "《中国动物本草》", 30 June 2014 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115554347A (en) * | 2022-08-25 | 2023-01-03 | 河南农业大学 | Virus inhibitor and preparation method and application thereof |
| CN115554347B (en) * | 2022-08-25 | 2023-09-19 | 河南农业大学 | Virus inhibitor and preparation method and application thereof |
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Application publication date: 20170222 |
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