CN106362007A - Traditional Chinese medicine composition containing dendrobium huoshanense and achieving glucose lowering effect and preparation method thereof - Google Patents
Traditional Chinese medicine composition containing dendrobium huoshanense and achieving glucose lowering effect and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition containing dendrobium huoshanense and achieving a glucose lowering effect and a preparation method thereof. According to the traditional Chinese medicine composition containing dendrobium huoshanense and achieving the glucose lowering effect, Chinese herbal medicine dendrobium huoshanense, ginseng, fructus lycii and momordica grosvenori fruits are mixed together according to a determined weight part ratio. The preparation method of the traditional Chinese medicine composition containing dendrobium huoshanense and achieving the glucose lowering effect includes the steps that the Chinese herbal medicine dendrobium huoshanense, ginseng, fructus lycii and momordica grosvenori fruits are selected according to the determined weight part ratio; the selected Chinese herbal medicine dendrobium huoshanense, ginseng, fructus lycii and momordica grosvenori fruits are mixed together, a solvent ethyl alcohol is added, mixed liquid is prepared, an extracting solution, with pharmaceutical value, in the mixed liquor is obtained through a reflux extraction mode, medicine residues are filtered out, the extracting solution is treated, and the traditional Chinese medicine composition containing dendrobium huoshanense and achieving the glucose lowering effect is obtained. Medicinal auxiliary materials are added into the traditional Chinese medicine composition, so that a traditional Chinese medicine preparation with the glucose lowering effect is prepared.
Description
Technical field
The invention belongs to medicine and health treatment technical field are and in particular to the Chinese medicine with blood sugar reducing function containing Herba Dendrobii
Compositionss and preparation method thereof, have Chinese medicine composition of blood sugar reducing function and preparation method thereof particularly containing Herba Dendrobii.
Background technology
It is known that diabetes are moderns through being commonly encountered and being difficult the disease cured.Scientific research confirms, diabetes
It is a kind of disease being detrimental to health being caused by heredity and environmental factorss.Diabetes can cause the complication of multiple diseases.
For example, diabetes can lead to sugar, the endocrine metabolism of protein, insecondary water-electrolyte metabolism disorder and acid base imbalance
Disorder, can cause chronic vascular and the neural complication of patient when serious, so that patient is disabled or dead.
In diabeticss body, lasting hyperglycemia can lead to the generation of many acute and chronic complication, for example, retina, kidney
Dirty, nervous system lesion and vascular complication.Vascular complication is the lethal main cause disabling of diabeticss.
The acute complicationses that diabetes cause common are: ketoacidosiss, hyperosmolar nonketotic diabetic coma and breast
Acid acidosis；The chronic complicating diseases that diabetes cause common are: big blood vessel, microvascular complication, sensory nerve, motion god
Warp, vegetative nerve complication etc..
Additionally, diabetes also can cause concurrent infection, including gingival infection, respiratory tract infection (as pulmonary tuberculosis), urinary system
Togetherness dye and skin infection etc..
According to relevant information introduction, diabetes have become the third-largest lethal disease being only second to cardiovascular diseasess, Cancerous disease
Disease.Raising with living standards of the people and the improvement of trophic structure, diabetes are being in multiple trend.At present, the whole world is about
There are 1.5 hundred million diabeticss, the onset diabetes rate of developed country is 3%～5%.The data of 1996 shows, at that time China's sugar
The sick prevalence of urine is 3.2%, annual rate of growth 0.1% about it is estimated that, diabeticss sum may reach 4000 at present for China
Ten thousand.
Applicant is found by research, and the diabeticss of China have the reason sharply increase: 1) inherited genetic factorss: China
The Susceptible population of diabetes is more；2) socio-economic factor: living standards of the people improve, popular to diabetes provides material
Basis；3) life style: calorie intake is excessive, physical exertion reduces, and mental pressure increases, and rhythm of life is accelerated, and leads to the modern times
The life style of people is unhealthy, not science.
Chinese patent literature cn1323625 disclose a kind of " there is the Chinese medicine composition of blood sugar reducing function " (application number:
01115415.2), it is made up of Gymnema P.E, green tea extract and the acceptable adjuvant of solid preparation, wherein described
Compositionss in for extract Radix Gymnematis Sylvestriss and the Radix Gymnematis Sylvestriss of green tea extract and the weight of green tea materials than 20: 1 to 2: 1 it
Between.Animal experiment shows that the Chinese medicine composition of the present invention has obvious hypoglycemic activity, can be used for preventing diabetes.
At present, the antidiabetic medicine clinically using can be divided into exogenous insulin, Drugs Promoting Insulin Secretion (sulfonylurea
Class, meglitinide), biguanideses, Study of Thiazolidinedione derivatives as Insulin Sensitizer, alpha-glucosidase inhibitor, diyl peptidase-vi (dpp-
Vi) inhibitor etc..Above-mentioned diabetes medicine has good curative effect, but there is also some deficiencies, particularly in prevention sugar
The sick complication aspect of urine is just less desirable.Some potential diabetic complication loyalty persons need more effective in cure more preferably medicine badly
Thing.
Content of the invention
The purpose of the present invention is, for the deficiencies in the prior art, improves, and proposes and studies containing Huoshan stone
Dry measure used in former times there is Chinese medicine composition of blood sugar reducing function and preparation method thereof.
The technical solution of the present invention is:
The Chinese medicine composition with blood sugar reducing function containing Herba Dendrobii, using Chinese crude drug it is characterised in that Chinese crude drug is using suddenly
Mountain Herba Dendrobii, Radix Ginseng, Fructus Lycii, Fructus Momordicae；By the ratio of weight and number determining, Herba Dendrobii, Radix Ginseng, Fructus Lycii, Fructus Momordicae combination
Together.
It is characterized in that, the Herba Dendrobii combined, Radix Ginseng, Fructus Lycii, the respective parts by weight of Fructus Momordicae are:
1～5 part of Herba Dendrobii, 2～6 parts of Radix Ginseng, 3～6 parts of Fructus Lycii, 2～4 parts of Fructus Momordicae.
It is characterized in that, the Herba Dendrobii combined, Radix Ginseng, Fructus Lycii, the respective parts by weight of Fructus Momordicae are:
3 parts of Herba Dendrobii, 4 parts of Radix Ginseng, 4 parts of Fructus Lycii, 3 parts of Fructus Momordicae.
The preparation method of the Chinese medicine composition with blood sugar reducing function containing Herba Dendrobii, by the ratio of weight and number choosing determining
Selecting Chinese crude drug, to the Chinese crude drug preparation selecting, obtaining Chinese medicine composition it is characterised in that selecting by the ratio of weight and number determining
Chinese crude drug be Herba Dendrobii, Radix Ginseng, Fructus Lycii, Fructus Momordicae；To the method for the Chinese crude drug preparation selecting it is, in choosing
Medical material Herba Dendrobii, Radix Ginseng, Fructus Lycii, Fructus Momordicae mix, and add etoh solvent to make mixed liquor, using reflux, extract,
Method, obtaining in mixed liquor has the extracting solution of medical value, filters off medicinal residues, extracting solution is processed, obtains containing Huoshan
Herba Dendrobii, the Chinese medicine composition of Radix Ginseng, Fructus Lycii and Fructus Momordicae pharmaceutical compositions；Step includes:
Step 1, selects Chinese crude drug: weigh Herba Dendrobii, Radix Ginseng, Fructus Lycii and Fructus Momordicae by ratio of weight and the number of copies；
Step 2, produces mixed liquor: add ethanol to make mixing after weighing Herba Dendrobii, Radix Ginseng, Fructus Lycii and Fructus Momordicae mixing
Liquid, fully stirs companion to medicine in mixed liquor, improves the liquor strength of drug-eluting in mixed liquor；
Step 3, reflux, extract: using the method for reflux, extract, the mixed liquor that step 2 is produced carries out reflux, extract, mixed liquor
Reflux, extract, 2 times, 2～3 hours every time, obtains extracting solution, filters off medicinal residues.
Step 4, is processed to extracting solution: the extracting solution of 2 extractions in combining step 3, extracting solution is carried out reduce pressure dense
Contract spray-dried, obtain dried powder, sieve, obtain containing Herba Dendrobii, Radix Ginseng, Fructus Lycii and Fructus Momordicae pharmaceutical compositions
Chinese medicine composition.
It is characterized in that, the concentration of the ethanol adding in step 2 is 60%
A kind of Chinese medicine preparation being made up of the Chinese medicine composition with blood sugar reducing function containing Herba Dendrobii, including pharmaceutical auxiliary
Material is it is characterised in that using the Chinese medicine composition with blood sugar reducing function containing Herba Dendrobii, according to preparation needs, containing
Having in the Chinese medicine composition of blood sugar reducing function of Herba Dendrobii is equipped with a certain amount of pharmaceutical adjuvant in the ratio determining, in making
Medicine preparation.
It is characterized in that, the Chinese medicine preparation made is slow releasing agent in medical common formulations, granule, capsule, capsule, piece
Agent, oral liquid.
Herba Dendrobii, Radix Ginseng, Fructus Lycii, the Ji Yuan of Fructus Momordicae and medical value, health care that the present invention adopts are as follows:
Herba Dendrobii: Herba Dendrobii be orchid family Dendrobium (dendrobium) herbaceos perennial, it is China's tradition rare Chinese medicine,
All on the books in many allusions medical book such as Shennong's Herbal, " Taoist Scriptures ", Compendium of Material Medica, " preemergency a thousand pieces of gold prescription ", and will
It is classified as " top grade ".Record according to history tree, Herba Dendrobii has nourishing YIN and clearing away heat, the stomach reinforcing that promotes the production of body fluid, the improving eyesight that wets one's whistle, life lengthening ground, mends
The five internal organs asthenia sea is thin, reinforcing YIN-essence and the effect of except deficiency-heat etc..
Herba Dendrobii (scientific name: dendrobium huoshanense) is commonly called as a meter dry measure used in former times, is the herbaceous plant of orchid family Dendrobium.
China national geography famous special product.Main product in Huoshan County of Anhui Province of Da Bie Mountain area, is grown in the steep cliff that cloud and mist curls up high and steep mostly
Between wall cliffstone gap and on old trees that reach into the skies.Herba Dendrobii can increase substantially the main matter of sod(slow down aging in human body) water
Flat, to often staying up late, using, brain, tobacco and wine are excessive, and the weak crowd of body void often drinks and is particularly suitable for.Herba Dendrobii has improving eyesight to make
With, also can YIN and YANG balance regulating, strengthening yang and invigorating kidney, skin care stay hold, thus reaching effect of health-care.
Modern study shows, the active component of Herba Dendrobii mainly has the chemical compositions such as alkaloid, aminoacid and polysaccharide.Pharmacology
Research shows, Herba Dendrobii is improving human body immunity, defying age, antitumor, improving diabetic symptom, treatment atrophic gastritis etc.
Aspect has a significant curative effect, is particularly in recent years used for eliminating cancer radiation, the side effect after chemotherapy and recovers function aspects, effect ten
Clearly show.Applicant thinks: in all Herba Dendrobii products, the Herba Dendrobii that is produced from Huoshan includes Herba Dendrobii (also known as rice dry measure used in former times), iron sheet stone
The property of medicine of dry measure used in former times and Dendrobium Moniliforme is good, is the good merchantable brand in Herba Dendrobii.Shennong's Herbal is recorded, " on the other stone of the raw six peace mountain valley water of Herba Dendrobii,
Adopt stem August in July to dry in the shade ", this is the earliest record in history tree to the Herba Dendrobii place of production and habitat.Main three kinds producing in Huoshan
In Herba Dendrobii kind, Herba Dendrobii (dendrobium huoshanense, rice dry measure used in former times) and the most rare precious, just praised highly by doctor from ancient times
For the treasure being used as medicine in Herba Dendrobii, it is referred to as " help Herba mesonae chinensis ", " soft gold ", " plant gold ".Compendium of Material Medica, " middle Hua Da medicine
Allusion quotation " etc. medical science ancient books and records rice dry measure used in former times has been carried out detailed record and describe.
Radix Ginseng: Araliaceae, panax speciespanax ginsengC. the root of a. mey, another name SHANSHEN, Park Ginseng, people
Rank, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.), wooden club, Rhizoma Panacis Japonici, SHENCAO etc.., Radix Ginseng is herbaceos perennial, and happiness is shady and cool, moistening weather, is grown on round the clock more
In the theropencedrymion of the little height above sea level of the temperature difference 500～1100 meters of mountain regions gentle slope or slope land or shaw.Because root is loose, shape
If spindle, often there is bifurcated, overall picture is quite like the head of people, handss, foot and extremity, so referred to as Radix Ginseng.The refined referred to as Rhizoma Polygonati of ancient times Radix Ginseng,
Herba Stellariae Saxatilis, SHENCAO.The Radix Polygoni Multiflori, the dried root of polygonum multiflorum thunb polygonum multiflorum thunb., its rattan claims
" Caulis Polygoni Multiflori ".Excavation when autumn, two season of winter leaf are withered, two ends of pruning, clean, individual big be cut into block, be dried.Radix Ginseng have " tonifying five ZANG-organses,
Soothe the nerves, determine soul, stop palpitate with fear, remove pathogenic factor, the happy Fructus Alpiniae Oxyphyllae of improving eyesight " effect, " long term usage make light of one's life by commiting suicide macrobiosis ".Li Shizhen (1518-1593 A.D.) is in " book on Chinese herbal medicine
Detailed outline " in also Radix Ginseng is extremely praised highly it is believed that it " can control all deficient syndromes of male woman ".For thousands of years, in Chinese herbal medicine, Radix Ginseng is all arranged
For " top grade ".
Fructus Lycii: plant of Solanaceae lycium barbarumlycium barbarumL. dry mature fruit.Fructus Lycii sweet in the mouth,
Mild-natured, enter liver, kidney, lung meridian.Cure mainly caused by liver and kidney deficiency, have a dizzy spell, visually unclear, soreness of the waist and knees, impotence and seminal emission, cough due to consumptive disease,
Quench one's thirst taking fluids profusely.Compendium of Material Medica is recorded, and " long term usage heavily fortified point muscles and bones, makes light of one's life by commiting suicide not old Fructus Lycii, resistance to cold and summer-heat." traditional Chinese medical science commonly uses it to treat liver
Kidney yin lose, soreness of the waist and knees, dizziness, forgetful, dizzy, the many tear of blurred vision, the disease such as quench one's thirst, pass out semen.Modern pharmacology research confirms Chinese holly
Fructus Lycii scalable body's immunity, can effectively suppress tumour growth and cell mutation, there is slow down aging, anti-fatty liver, tune
The effect such as section blood fat and blood glucose, promotion hemopoietic function.
Fructus Momordicae: cucurbitaceous plant Fructus Momordicaesiraitia grosvenorii(swingle) c. jeffrey ex
The dry fruit of lu et z. y. zhang.Fructus Momordicae is described as " angle fruit ", cool in nature, sweet in the mouth by people.Return lung, large intestine channel.Tool
There are clearing heat and moistening lung, cough-relieving, sore-throat relieving, the effect of laxation relieving constipation.Clinically it is mainly used in lung-fire cough caused by dryness, pharyngalgia aphonia, dry constipation of intestines.
There is the Chinese medicine composition of blood sugar reducing function containing Herba Dendrobii: there is reduction blood glucose effect, diabetes are risen
Phase beginning, mid-term, late period all have blood sugar lowering definite, stable, especially to preventing and treating diabetic cardiovascular disease, diabetic cerebrovascular disease, glycosuria
Sick nephropathy, diabetes acral angiopathy, diabetic ophthalmopathy and early treatment can make early lesion reverse, in, late period can obviously improve
Symptom, prevention and control complication.
Pharmacological research shows, the Chinese medicine composition that there is blood sugar reducing function containing Herba Dendrobii can significantly reduce alloxan and
The concentration of blood glucose in streptozotocin inducing experimental diabetes rat model, action intensity and dosage are in good dependency.
Said composition can obviously improve weight loss during being administered for the diabetic model rats hence it is evident that suppressing its food ration and amount of drinking water
Increase, can obviously reduce type 2 diabetes mellitus rat model blood glucose and its saccharification hemoglobin content, improve its impaired glucose tolerance journey
Degree;The notable hyperinsulinemia alleviating type 2 diabetes mellitus rat model, improves its insulin resistance degree.Significantly reduce 2 type sugar
Urine disease model rat plasma triglyceride, T-CHOL and free fatty acid content, reduce its serum mda content, improve its blood
Clear no content.Weaken the number of ways such as the damage of lipid peroxidation and improve carbohydrate metabolism disturbance, control diabetic vascular, nerveous system
The generation of the complication such as system, kidney and development, alleviate and reduce the generation of diabetic complication.
The innovative point of the present invention is, 1, a kind of Chinese medicine composition containing Herba Dendrobii with blood sugar reducing function proposed by the present invention
Thing is to develop under instruction of Chinese Medicine theory, and it is a kind of Chinese medicine compound with blood sugar reducing function.2nd, proposed by the present invention one
Initial phase, mid-term, the symptom in late period all have blood sugar lowering true to diabetes kind to have the Chinese medicine composition of blood sugar reducing function containing Herba Dendrobii
Cut, stable curative effect, especially to preventing and treating diabetic cardiovascular disease, diabetic cerebrovascular disease, diabetic nephropathy, diabetes acral
Angiopathy, diabetic ophthalmopathy and early treatment have curative effect very, can make early lesion reverse, in, late period can obviously improve symptom, in advance
Complication that is anti-and controlling diabetes to cause.3rd, the Chinese medicine composition containing Herba Dendrobii with blood sugar reducing function proposed by the present invention
Preparation method is applied to large-scale industrial production.4th, the present invention is based on theory of Chinese medical science, according to traditional tcm health preserving and
Health care theory, selected rare Chinese medicine and general Chinese medicine, carry out prescription by its weight ratio, with rational preparation method, extract it
In elite, make Chinese medicine composition, to provide preferable hypoglycemic effect good for the medicine of producing prevention diabetic complication
Medicinal raw material.
It is an advantage of the invention that the component containing Herba Dendrobii with the Chinese medicine composition of blood sugar reducing function is appropriate, reasonable mixture ratio,
There is the fine blood glucose that reduces act on, to diabetes, initial phase, mid-term, the disease in late period have significant curative effect, and hypoglycemic effect is preferable,
Prevention and control diabetic complication are very helpful.The preparation method of the present invention is simple, convenient to carry out it is adaptable to big advise
Mould industrialized production.
Specific embodiment
Below, technology according to the present invention solution, describes embodiments of the invention in detail.
The Chinese medicine composition with blood sugar reducing function containing Herba Dendrobii proposed by the present invention, using Chinese crude drug, Chinese crude drug
Using Herba Dendrobii, Radix Ginseng, Fructus Lycii, Fructus Momordicae；By the ratio of weight and number determining, Herba Dendrobii, Radix Ginseng, Fructus Lycii, arhat
Fruit is combined.The Herba Dendrobii combined, Radix Ginseng, Fructus Lycii, the respective parts by weight of Fructus Momordicae are: Huoshan stone
1～5 part of dry measure used in former times, 2～6 parts of Radix Ginseng, 3～6 parts of Fructus Lycii, 2～4 parts of Fructus Momordicae.
Optimal selection is: the Herba Dendrobii combined, Radix Ginseng, Fructus Lycii, the respective parts by weight of Fructus Momordicae
It is: 3 parts of Herba Dendrobii, 4 parts of Radix Ginseng, 4 parts of Fructus Lycii, 3 parts of Fructus Momordicae.
The preparation method of the Chinese medicine composition with blood sugar reducing function containing Herba Dendrobii proposed by the present invention, by determine
Ratio of weight and number selects Chinese crude drug, to the Chinese crude drug preparation selecting, obtains Chinese medicine composition, selects by the ratio of weight and number determining
Chinese crude drug be Herba Dendrobii, Radix Ginseng, Fructus Lycii, Fructus Momordicae；To the method for the Chinese crude drug preparation selecting it is, in choosing
Medical material Herba Dendrobii, Radix Ginseng, Fructus Lycii, Fructus Momordicae mix, and add etoh solvent to make mixed liquor, using reflux, extract,
Method, obtain the extracting solution having medical value that has in mixed liquor, filter off medicinal residues, extracting solution is processed, is contained
Herba Dendrobii, the Chinese medicine composition of Radix Ginseng, Fructus Lycii and Fructus Momordicae pharmaceutical compositions；Step includes:
Step 1, selects Chinese crude drug: weigh Herba Dendrobii, Radix Ginseng, Fructus Lycii and Fructus Momordicae by ratio of weight and the number of copies；
Step 2, produces mixed liquor: add etoh solvent to make after weighing Herba Dendrobii, Radix Ginseng, Fructus Lycii and Fructus Momordicae mixing
Mixed liquor, fully stirs companion to medicine in mixed liquor, improves the liquor strength of drug-eluting in mixed liquor；
Step 3, reflux, extract: using the method for reflux, extract, the mixed liquor that step 2 is produced carries out reflux, extract, mixed liquor
Reflux, extract, 2 times, 2～3 hours every time, obtains extracting solution, filters off medicinal residues.
Step 4, is processed to extracting solution: the extracting solution of 2 extractions in combining step 3, extracting solution is carried out reduce pressure dense
Contract spray-dried, obtain dried powder, sieve, obtain containing Herba Dendrobii, Radix Ginseng, Fructus Lycii and Fructus Momordicae pharmaceutical compositions
Chinese medicine composition.
The concentration of the etoh solvent adding in step 2 is 60%
A kind of Chinese medicine preparation being made up of the Chinese medicine composition with blood sugar reducing function containing Herba Dendrobii, including pharmaceutical auxiliary
Material is it is characterised in that using the Chinese medicine composition with blood sugar reducing function containing Herba Dendrobii, according to preparation needs, containing
Having in the Chinese medicine composition of blood sugar reducing function of Herba Dendrobii is equipped with a certain amount of pharmaceutical adjuvant in the ratio determining, in making
Medicine preparation.
The Chinese medicine preparation made is slow releasing agent in medical common formulations, granule, capsule, capsule, tablet, oral liquid.
The Radix Ginseng that the Chinese medicine composition having blood sugar reducing function containing Herba Dendrobii proposed by the present invention adopts includes
Raw material, the decoction pieces being obtained through different concocting methods, such as Radix Ginseng Rubra, Radix Ginseng, Radix Ginseng (processed with sugar) etc..
Example 1: the application present invention makes the capsule containing Herba Dendrobii with blood sugar reducing function.
Using 60 grams of Herba Dendrobii, 80 grams of Radix Ginseng (or Radix Ginseng Rubra), 80 grams of Fructus Lycii, 60 grams of Fructus Momordicae, after mixing plus
Enter the alcohol reflux that 10 times amount concentration are 60% 2 times, 3 hours every time, filter off medicinal residues, united extraction liquid, extracting solution is carried out
Concentrating under reduced pressure, and spray-dried, obtain dried powder, sieve, obtain containing Herba Dendrobii, Radix Ginseng, Fructus Lycii and Fructus Momordicae
The Chinese medicine composition of pharmaceutical compositions.Herba Dendrobii, Radix Ginseng Rubra, Fructus Lycii, Fructus Momordicae ratio of weight and number are 4:6:6:4.
Using obtain containing Herba Dendrobii, Radix Ginseng, Fructus Lycii and Fructus Momordicae pharmaceutical compositions Chinese medicine composition as system with containing
Herba Dendrobii has the medicinal raw material of the capsule of blood sugar reducing function, containing Herba Dendrobii, Radix Ginseng, Fructus Lycii and Fructus Momordicae medicine
A certain amount of pharmaceutical adjuvant is added, the pharmaceutical adjuvant of addition is magnesium stearate in the Chinese medicine composition of composition.Addition is
Make the magnesium stearate of the raw material gross weight 3% of capsule, cross 200 mesh sieves, loading capsule is fabricated to be had containing Herba Dendrobii
The capsule of blood sugar reducing function.This capsule has reduction blood glucose effect, and to diabetes, initial phase, mid-term, late period all have blood sugar lowering true
Cut, stable, especially to preventing and treating diabetic cardiovascular disease, diabetic cerebrovascular disease, diabetic nephropathy, diabetes acral angiopathy,
Diabetic ophthalmopathy and early treatment can make early lesion reverse, in, late period can obviously improve symptom, prevention and control complication.
Example 2: the application present invention makes the tablet containing Herba Dendrobii with blood sugar reducing function.
Using 30 grams of Herba Dendrobii, 40 grams of Radix Ginseng (or Radix Ginseng Rubra), 40 grams of Fructus Lycii, 30 grams of Fructus Momordicae, add after mixing
15 times amount, 60% alcohol reflux 2 times, 3 hours every time, filters off medicinal residues, united extraction liquid, carries out concentrating under reduced pressure to extracting solution,
And spray-dried, obtain dried powder, sieve, obtain containing Herba Dendrobii, Radix Ginseng, Fructus Lycii and Fructus Momordicae pharmaceutical compositions
Chinese medicine composition.Herba Dendrobii, Radix Ginseng Rubra, Fructus Lycii, Fructus Momordicae ratio of weight and number are: 3:4:4:3.To obtain containing Huoshan stone
Dry measure used in former times, the Chinese medicine composition of Radix Ginseng, Fructus Lycii and Fructus Momordicae pharmaceutical compositions are as system with having the piece of blood sugar reducing function containing Herba Dendrobii
The medicinal raw material of agent.Medicine is added in containing Herba Dendrobii, the Chinese medicine composition of Radix Ginseng, Fructus Lycii and Fructus Momordicae pharmaceutical compositions
With adjuvant, the pharmaceutical adjuvant of addition is Microcrystalline Cellulose, Microcrystalline Cellulose addition by the tablet processed it needs to be determined that, mistake
200 mesh sieves, pelletize, are pressed into the tablet containing Herba Dendrobii with blood sugar reducing function.This tablet has reduction blood glucose effect, to sugar
Urine disease initial phase, mid-term, late period all has blood sugar lowering definite, stable, especially to preventing and treating diabetic cardiovascular disease, diabetes cerebrovascular
Disease, diabetic nephropathy, diabetes acral angiopathy, diabetic ophthalmopathy and early treatment can make early lesion reverse, in, late period can be bright
Show and improve symptom, prevent and control complication.
Example 3: the application present invention makes the granule containing Herba Dendrobii with blood sugar reducing function.
Using 90 grams of Herba Dendrobii, 110 grams of Radix Ginseng (or Radix Ginseng Rubra), 110 grams of Fructus Lycii, 90 grams of Fructus Momordicae, after mixing plus
Enter the alcohol reflux that 10 times amount concentration are 60% 2 times, 3 hours every time, filter off medicinal residues, united extraction liquid, extracting solution is carried out
Concentrating under reduced pressure, and spray-dried, obtain dried powder, sieve, obtain containing Herba Dendrobii, Radix Ginseng, Fructus Lycii and arhat
The Chinese medicine composition of fruit pharmaceutical compositions.Herba Dendrobii, Radix Ginseng, Fructus Lycii, Fructus Momordicae ratio of weight and number are 4.5:5.5:5.5:
4.5.Herba Dendrobii, Radix Ginseng Rubra, Fructus Lycii, Fructus Momordicae ratio of weight and number are 4:6:6:4.By obtain containing Herba Dendrobii, Radix Ginseng,
The Chinese medicine composition of Fructus Lycii and Fructus Momordicae pharmaceutical compositions is as system with having the medicine of the granule of blood sugar reducing function containing Herba Dendrobii
Use raw material.Add a certain amount of doctor in containing Herba Dendrobii, the Chinese medicine composition of Radix Ginseng, Fructus Lycii and Fructus Momordicae pharmaceutical compositions
Pharmaceutic adjuvant, a certain amount of pharmaceutical adjuvant of addition is sucrose, crosses 200 mesh sieves, then pelletizes, that is, is fabricated to containing Herba Dendrobii
There is the granule of blood sugar reducing function.The addition of sucrose is pressed the technical requirements pelletized and is determined.Containing Herba Dendrobii, there is blood sugar reducing function
Granule there is reduction blood glucose effect, diabetes are initiateed with phase, mid-term, late period all has blood sugar lowering definite, stable, especially to preventing and treating
Diabetic cardiovascular disease, diabetic cerebrovascular disease, diabetic nephropathy, diabetes acral angiopathy, diabetic ophthalmopathy and early treatment
Early lesion can be made to reverse, in, late period can obviously improve symptom, prevention and control complication.
The above embodiment of the present invention only technology design to illustrate the invention and bare bones realizing the present invention, its mesh
Be to allow and understand that those skilled in the art of the technology of the present invention solution will appreciate that the present invention covers technology contents, and
Implement according to this, the protection domain that technical solution proposed by the present invention covers can not be limited with this.All according to the present invention
The equivalent transformation that the substantial technological content proposing is done becomes to modify, and all should be included within the scope of the present invention.
Claims (4)
1. the Chinese medicine composition with blood sugar reducing function containing Herba Dendrobii, using Chinese crude drug it is characterised in that Chinese crude drug adopts
Herba Dendrobii, Radix Ginseng, Fructus Lycii, Fructus Momordicae；By the ratio of weight and number determining, by Herba Dendrobii, Radix Ginseng, Fructus Lycii, Fructus Momordicae
Combine；To the Chinese crude drug preparation selecting, obtain Chinese medicine composition, to the method for the Chinese medicine former material preparation selecting be, will
The raw material of Chinese medicine Herba Dendrobii that chooses, Radix Ginseng, Fructus Lycii, Fructus Momordicae mix, and add etoh solvent to make mixed liquor,
Using the method for reflux, extract, obtain the extracting solution having medical value having in mixed liquor, filter off medicinal residues, at extracting solution
Reason, obtains the Chinese medicine composition containing Herba Dendrobii, Radix Ginseng, Fructus Lycii and Fructus Momordicae pharmaceutical compositions.
2. the Chinese medicine composition with blood sugar reducing function containing Herba Dendrobii according to claim 1 is it is characterised in that group
The Herba Dendrobii that is combined, Radix Ginseng, Fructus Lycii, the respective parts by weight of Fructus Momordicae are: 1～5 part of Herba Dendrobii, Radix Ginseng 2
～6 parts, 3～6 parts of Fructus Lycii, 2～4 parts of Fructus Momordicae.
3. the Chinese medicine composition with blood sugar reducing function containing Herba Dendrobii according to claim 1 is it is characterised in that group
The Herba Dendrobii that is combined, Radix Ginseng, Fructus Lycii, the respective parts by weight of Fructus Momordicae are: 3 parts of Herba Dendrobii, 4 parts of Radix Ginseng,
4 parts of Fructus Lycii, 3 parts of Fructus Momordicae.
4. the preparation method of the Chinese medicine composition with blood sugar reducing function containing Herba Dendrobii, is selected by the ratio of weight and number determining
Chinese crude drug, to the Chinese crude drug preparation selecting, obtains Chinese medicine composition it is characterised in that the Chinese crude drug selecting is Herba Dendrobii, people
Ginseng, Fructus Lycii, Fructus Momordicae；To the method for the Chinese medicine former material preparation selecting it is, by the raw material of Chinese medicine choosing Herba Dendrobii, people
Ginseng, Fructus Lycii, Fructus Momordicae mix, and add etoh solvent to make mixed liquor, using the method for reflux, extract, obtain mixing
The extracting solution having medical value having in liquid, filters off medicinal residues, extracting solution is processed, obtains containing Herba Dendrobii, Radix Ginseng, Chinese holly
Fructus Lycii and the Chinese medicine composition of Fructus Momordicae pharmaceutical compositions；Step includes:
Step 1, selects Chinese crude drug: weigh Herba Dendrobii, Radix Ginseng, Fructus Lycii and Fructus Momordicae by ratio of weight and the number of copies；
Step 2, produces mixed liquor: add ethanol to make mixing after weighing Herba Dendrobii, Radix Ginseng, Fructus Lycii and Fructus Momordicae mixing
Liquid, fully stirs companion to medicine in mixed liquor, improves the liquor strength of drug-eluting in mixed liquor；
Step 3, reflux, extract: using the method for reflux, extract, the mixed liquor that step 2 is produced carries out reflux, extract, mixed liquor
Reflux, extract, 2 times, 2～3 hours every time, obtains extracting solution, filters off medicinal residues；
Step 4, is processed to extracting solution: the extracting solution of 2 extractions in combining step 3, carries out concentrating under reduced pressure simultaneously to extracting solution
Spray-dried, obtain dried powder, sieve, obtain containing in Herba Dendrobii, Radix Ginseng, Fructus Lycii and Fructus Momordicae pharmaceutical compositions
Drug composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611053455.5A CN106362007A (en) | 2016-11-25 | 2016-11-25 | Traditional Chinese medicine composition containing dendrobium huoshanense and achieving glucose lowering effect and preparation method thereof |
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| CN201611053455.5A CN106362007A (en) | 2016-11-25 | 2016-11-25 | Traditional Chinese medicine composition containing dendrobium huoshanense and achieving glucose lowering effect and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108514111A (en) * | 2018-03-05 | 2018-09-11 | 安徽省霍山县福康石斛开发有限公司 | A kind of preparation method of nourishing blood and liver stem of noble dendrobium cake |
| CN109370852A (en) * | 2018-11-26 | 2019-02-22 | 邵武市南武夷中药材种植专业合作社 | A kind of sealwort wine and preparation method thereof |
| CN113080454A (en) * | 2021-05-10 | 2021-07-09 | 皖西学院 | Dendrobium huoshanense ginseng oral liquid and preparation process and application thereof |
-
2016
- 2016-11-25 CN CN201611053455.5A patent/CN106362007A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108514111A (en) * | 2018-03-05 | 2018-09-11 | 安徽省霍山县福康石斛开发有限公司 | A kind of preparation method of nourishing blood and liver stem of noble dendrobium cake |
| CN109370852A (en) * | 2018-11-26 | 2019-02-22 | 邵武市南武夷中药材种植专业合作社 | A kind of sealwort wine and preparation method thereof |
| CN113080454A (en) * | 2021-05-10 | 2021-07-09 | 皖西学院 | Dendrobium huoshanense ginseng oral liquid and preparation process and application thereof |
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Application publication date: 20170201 |