CN106267333A - A kind of antibacterial ability and the preferable biomedical metallic material of decay resistance - Google Patents

A kind of antibacterial ability and the preferable biomedical metallic material of decay resistance Download PDF

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CN106267333A
CN106267333A CN201610730219.6A CN201610730219A CN106267333A CN 106267333 A CN106267333 A CN 106267333A CN 201610730219 A CN201610730219 A CN 201610730219A CN 106267333 A CN106267333 A CN 106267333A
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antioxidant
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不公告发明人
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    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C47/00—Making alloys containing metallic or non-metallic fibres or filaments
    • C22C47/14—Making alloys containing metallic or non-metallic fibres or filaments by powder metallurgy, i.e. by processing mixtures of metal powder and fibres or filaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/022—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/028—Other inorganic materials not covered by A61L31/022 - A61L31/026
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C49/00—Alloys containing metallic or non-metallic fibres or filaments
    • C22C49/02—Alloys containing metallic or non-metallic fibres or filaments characterised by the matrix material
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C49/00—Alloys containing metallic or non-metallic fibres or filaments
    • C22C49/14—Alloys containing metallic or non-metallic fibres or filaments characterised by the fibres or filaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Abstract

The invention provides a kind of antibacterial ability and the preferable biomedical metallic material of decay resistance, described metal material raw material includes niobium powder, platinum powder, titanium valve, molybdenum powder, cellulose nitrate, triphenyl phosphate, antioxidant, auxiliary antioxidant, wollastonite fibre, dibutyl tin mercaptides, dibutyl phthalate, triphenyl phosphite, Hyaluronic Acid, starch, calcium silicates and 2 ethyl 4 Methylimidazole .s.Its preparation method is for first to add in mixing and blending machine by each component, it is uniformly mixed, gained mixed material is joined in reactor, heated and stirred reaction in nitrogen atmosphere, by extruded in gained reactant feeding double screw extruder, water-cooled, air-dried, pelletizing, obtain biomedical metallic material.Gained biomedical metallic material not only hardness of the present invention and corrosion resistant performance have raising in various degree, and escherichia coli and staphylococcus aureus are respectively provided with good antibacterial ability, and its antibiotic rate respectively reaches 99.5% and 98.45%.

Description

A kind of antibacterial ability and the preferable biomedical metallic material of decay resistance
Technical field
The invention belongs to biology medical material technical field, be specifically related to a kind of biomedical metallic material and preparation side thereof Method.
Background technology
Bio-medical material refers to for medically implanting organism or the material combined with biological tissue, available In diagnosis, treatment, and replace tissue, the organ in living organism or promote its function.It is currently used for the bio-medical of clinic Material mainly includes biomedical metallic material, bio-medical organic material (referring mainly to high-molecular organic material), bio-medical Inorganic Non-metallic Materials (referring mainly to bioceramic), bio-vitric and carbon materials and bio-medical composition etc..With life Thing pottery and bioabsorbable polymer material are compared, biomedical metallic material, such as rustless steel, cobalt-base alloys, titanium and titanium alloy and Noble metals etc. have the many such as high intensity, good toughness and counter-bending fatigue strength, excellent processing characteristics, and other are medical The irreplaceable premium properties of material.
The subject matter that biomedical metallic material faces in the application, is the gold caused due to the corrosion of physiological environment Belonging to ion to spread and the regression of embedded material self property to surrounding tissue, the former may cause toxic and side effects, and the latter may Cause graft failure.Medical metal material as a class of biomaterial, its research and development strictly to meet as follows from life Thing require: good histocompatibility, including avirulence, without heat source response, not teratogenesis, the most carcinogenic, do not cause allergic reaction Or the immune mechanism of interference body, do not destroy adjacent tissue, the most the calcification on generating material surface is calm etc.；Good physics, Chemical stability, including intensity, elasticity, dimensional stability, corrosion resistance, wearability and interface stability etc.；It is prone to processing Molding, material is easily fabricated；Price is suitable.
Therefore, research and development performance is more excellent, and biocompatibility more preferable new bio medical metal material is material supplier Author and the problem of medical personnel's common concern.
Summary of the invention
It is an object of the invention to overcome the deficiencies in the prior art to provide a kind of biomedical metallic material and preparation side thereof Method, this material has good antibiotic property, mechanical property and decay resistance.
A kind of biomedical metallic material, raw material includes in parts by weight: niobium powder 3～9 parts, platinum powder 2～8 parts, titanium valve 1～ 7 parts, molybdenum powder 2～7 parts, cellulose nitrate 1～6 parts, triphenyl phosphate 3～8 parts, antioxidant 1～7 parts, auxiliary antioxidant 2～ 8 parts, wollastonite fibre 1～5 parts, dibutyl tin mercaptides 2～7 parts, dibutyl phthalate 3～9 parts, triphenyl phosphite 3 ～8 parts, Hyaluronic Acid 2～7 parts, starch 1～8 parts, calcium silicates 2～9 parts, 2-ethyl-4-methylimidazole 1～6 parts.
As the further improvement of foregoing invention, the granularity of described niobium powder, platinum powder, titanium valve and molybdenum powder is 100～200 mesh.
As the further improvement of foregoing invention, described antioxidant is the mixture of antioxidant 1010 and antioxidant 1076, Wherein, the weight ratio of antioxidant 1010 and antioxidant 1076 is 3:2.
As the further improvement of foregoing invention, described auxiliary antioxidant is the double lauryl of thio-2 acid.
The preparation method of above-mentioned biomedical metallic material, comprises the following steps:
Step 1, adds to, in mixing and blending machine, be uniformly mixed by each component, obtains mixed material；
Step 2, joins in reactor by step 1 gained mixed material, is heated to 65～80 DEG C in nitrogen atmosphere, and stirring is anti- Answer 30～40min, obtain reactant；
Step 3, by extruded in step 2 gained reactant feeding double screw extruder, water-cooled, air-dried, pelletizing, obtains biological doctor Use metal material.
As the further improvement of foregoing invention, the mixing speed being uniformly mixed in step 1 is 300～400rpm, Mixing time is 20～40min.
As the further improvement of foregoing invention, in step 3, the extrusion condition of double screw extruder is: district's temperature 180 ～200 DEG C, two district's temperature 200～220 DEG C, three district's temperature 210～230 DEG C, four district's temperature 230～250 DEG C, screw speed is 160～180rpm.
The biomedical metallic material of the present invention not only hardness and corrosion resistant performance have raising in various degree, and to greatly Enterobacteria and staphylococcus aureus are respectively provided with good antibacterial ability, and its antibiotic rate respectively reaches 99.5% and 98.45%, The requirement of the antibiotic property needed for biomedical metallic material, mechanical property and decay resistance can be met.
Detailed description of the invention
Embodiment 1
A kind of biomedical metallic material, raw material includes in parts by weight: 3 parts of niobium powder, platinum powder 2 parts, titanium valve 1 part, molybdenum powder 2 parts, Cellulose nitrate 1 part, triphenyl phosphate 3 parts, 1 part of antioxidant, auxiliary antioxidant 2 parts, wollastonite fibre 1 part, dibutyl sulfide 2 parts of alcohol stannum, dibutyl phthalate 3 parts, triphenyl phosphite 3 parts, Hyaluronic Acid 2 parts, starch 1 part, calcium silicates 2 parts, 2-second Base-4-methylimidazole 1 part.
The granularity of above-mentioned niobium powder, platinum powder, titanium valve and molybdenum powder is 100 mesh.
Above-mentioned antioxidant is the mixture of antioxidant 1010 and antioxidant 1076, wherein, and antioxidant 1010 and antioxidant The weight ratio of 1076 is 3:2.
Above-mentioned auxiliary antioxidant is the double lauryl of thio-2 acid.
The preparation method of above-mentioned biomedical metallic material, comprises the following steps:
Step 1, adds to, in mixing and blending machine, be uniformly mixed by each component, and mixing speed is 300rpm, and mixing time is 40min, obtains mixed material；
Step 2, joins in reactor by step 1 gained mixed material, is heated to 65 DEG C in nitrogen atmosphere, stirring reaction 40min, obtains reactant；
Step 3, by extruded in step 2 gained reactant feeding double screw extruder, water-cooled, air-dried, pelletizing, obtains biological doctor With metal material, wherein the extrusion condition of double screw extruder is: district's temperature 180 DEG C, two district's temperature 200 DEG C, three district's temperature 210 DEG C, four district's temperature 230 DEG C, screw speed is 160rpm.
Embodiment 2
A kind of biomedical metallic material, raw material includes in parts by weight: 4 parts of niobium powder, platinum powder 6 parts, titanium valve 2 parts, molybdenum powder 3 parts, Cellulose nitrate 5 parts, triphenyl phosphate 6 parts, 2 parts of antioxidant, auxiliary antioxidant 5 parts, wollastonite fibre 4 parts, dibutyl sulfide 5 parts of alcohol stannum, dibutyl phthalate 8 parts, triphenyl phosphite 7 parts, Hyaluronic Acid 5 parts, starch 3 parts, calcium silicates 5 parts, 2-second Base-4-methylimidazole 3 parts.
The granularity of above-mentioned niobium powder, platinum powder, titanium valve and molybdenum powder is 140 mesh.
Above-mentioned antioxidant is the mixture of antioxidant 1010 and antioxidant 1076, wherein, and antioxidant 1010 and antioxidant The weight ratio of 1076 is 3:2.
Above-mentioned auxiliary antioxidant is the double lauryl of thio-2 acid.
The preparation method of above-mentioned biomedical metallic material, comprises the following steps:
Step 1, adds to, in mixing and blending machine, be uniformly mixed by each component, and mixing speed is 350rpm, and mixing time is 30min, obtains mixed material；
Step 2, joins in reactor by step 1 gained mixed material, is heated to 75 DEG C in nitrogen atmosphere, stirring reaction 35min, obtains reactant；
Step 3, by extruded in step 2 gained reactant feeding double screw extruder, water-cooled, air-dried, pelletizing, obtains biological doctor With metal material, wherein the extrusion condition of double screw extruder is: district's temperature 190 DEG C, two district's temperature 210 DEG C, three district's temperature 220 DEG C, four district's temperature 240 DEG C, screw speed is 170rpm.
Embodiment 3
A kind of biomedical metallic material, raw material includes in parts by weight: 7 parts of niobium powder, platinum powder 3 parts, titanium valve 2 parts, molybdenum powder 3 parts, Cellulose nitrate 5 parts, triphenyl phosphate 6 parts, 2 parts of antioxidant, auxiliary antioxidant 3 parts, wollastonite fibre 4 parts, dibutyl sulfide 6 parts of alcohol stannum, dibutyl phthalate 8 parts, triphenyl phosphite 5 parts, Hyaluronic Acid 4 parts, starch 3 parts, calcium silicates 7 parts, 2-second Base-4-methylimidazole 2 parts.
The granularity of above-mentioned niobium powder, platinum powder, titanium valve and molybdenum powder is 160 mesh.
Above-mentioned antioxidant is the mixture of antioxidant 1010 and antioxidant 1076, wherein, and antioxidant 1010 and antioxidant The weight ratio of 1076 is 3:2.
Above-mentioned auxiliary antioxidant is the double lauryl of thio-2 acid.
The preparation method of above-mentioned biomedical metallic material, comprises the following steps:
Step 1, adds to, in mixing and blending machine, be uniformly mixed by each component, and mixing speed is 400rpm, and mixing time is 20min, obtains mixed material；
Step 2, joins in reactor by step 1 gained mixed material, is heated to 80 DEG C in nitrogen atmosphere, stirring reaction 30min, obtains reactant；
Step 3, by extruded in step 2 gained reactant feeding double screw extruder, water-cooled, air-dried, pelletizing, obtains biological doctor With metal material, wherein the extrusion condition of double screw extruder is: district's temperature 200 DEG C, two district's temperature 220 DEG C, three district's temperature 230 DEG C, four district's temperature 250 DEG C, screw speed is 180rpm.
Embodiment 4
A kind of biomedical metallic material, raw material includes in parts by weight: 5 parts of niobium powder, platinum powder 3 parts, titanium valve 6 parts, molybdenum powder 4 parts, Cellulose nitrate 2 parts, triphenyl phosphate 6 parts, 4 parts of antioxidant, auxiliary antioxidant 7 parts, wollastonite fibre 3 parts, dibutyl sulfide 5 parts of alcohol stannum, dibutyl phthalate 8 parts, triphenyl phosphite 4 parts, Hyaluronic Acid 3 parts, starch 6 parts, calcium silicates 7 parts, 2-second Base-4-methylimidazole 5 parts.
The granularity of above-mentioned niobium powder, platinum powder, titanium valve and molybdenum powder is 120 mesh.
Above-mentioned antioxidant is the mixture of antioxidant 1010 and antioxidant 1076, wherein, and antioxidant 1010 and antioxidant The weight ratio of 1076 is 3:2.
Above-mentioned auxiliary antioxidant is the double lauryl of thio-2 acid.
The preparation method of above-mentioned biomedical metallic material, comprises the following steps:
Step 1, adds to, in mixing and blending machine, be uniformly mixed by each component, and mixing speed is 300rpm, and mixing time is 40min, obtains mixed material；
Step 2, joins in reactor by step 1 gained mixed material, is heated to 65 DEG C in nitrogen atmosphere, stirring reaction 40min, obtains reactant；
Step 3, by extruded in step 2 gained reactant feeding double screw extruder, water-cooled, air-dried, pelletizing, obtains biological doctor With metal material, wherein the extrusion condition of double screw extruder is: district's temperature 180 DEG C, two district's temperature 200 DEG C, three district's temperature 210 DEG C, four district's temperature 230 DEG C, screw speed is 160rpm.
Embodiment 5
A kind of biomedical metallic material, raw material includes in parts by weight: 9 parts of niobium powder, platinum powder 8 parts, titanium valve 7 parts, molybdenum powder 7 parts, Cellulose nitrate 6 parts, triphenyl phosphate 8 parts, 7 parts of antioxidant, auxiliary antioxidant 8 parts, wollastonite fibre 5 parts, dibutyl sulfide 7 parts of alcohol stannum, dibutyl phthalate 9 parts, triphenyl phosphite 8 parts, Hyaluronic Acid 7 parts, starch 8 parts, calcium silicates 9 parts, 2-second Base-4-methylimidazole 6 parts.
The granularity of above-mentioned niobium powder, platinum powder, titanium valve and molybdenum powder is 200 mesh.
Above-mentioned antioxidant is the mixture of antioxidant 1010 and antioxidant 1076, wherein, and antioxidant 1010 and antioxidant The weight ratio of 1076 is 3:2.
Above-mentioned auxiliary antioxidant is the double lauryl of thio-2 acid.
The preparation method of above-mentioned biomedical metallic material, comprises the following steps:
Step 1, adds to, in mixing and blending machine, be uniformly mixed by each component, and mixing speed is 400rpm, and mixing time is 20min, obtains mixed material；
Step 2, joins in reactor by step 1 gained mixed material, is heated to 80 DEG C in nitrogen atmosphere, stirring reaction 30min, obtains reactant；
Step 3, by extruded in step 2 gained reactant feeding double screw extruder, water-cooled, air-dried, pelletizing, obtains biological doctor With metal material, wherein the extrusion condition of double screw extruder is: district's temperature 200 DEG C, two district's temperature 220 DEG C, three district's temperature 230 DEG C, four district's temperature 250 DEG C, screw speed is 180rpm.
Test example 1
Embodiment 1 to 5 resulting materials is carried out corrosion resistant performance test: test sample is that working electrode, graphite rod are for electrode, sweet Mercury electrode is reference electrode, utilizes the corrosion resistant performance of electrochemical workstation (Shanghai occasion China CHI760C) test material, test voltage For-2V～2V.
Result shows, the material of the present invention is for pure titanium, and corrosion potential all offsets to positive direction, shows the present invention Material corrosion resistant ability strengthened, this existence being probably cellulose nitrate makes its corrosion resistant ability be improved.
Test example 2
Embodiment 1 to 5 resulting materials is carried out nano hardness test: (U.S.'s Mei Tesi process system has to utilize nano-hardness tester Limit company), with continuous hardness test, material is carried out nano hardness test, triangle Buddha's warrior attendant cone pressure head is 1mN's at load force Being 70nm at material surface compression distance under promotion, computer software records corresponding data simultaneously.The hardness number of sample is by surveying Amount five zoness of different of sample obtain.
Result shows, the material of the present invention is for pure titanium, and nano-hardness value all improves more than 15%.
Test example 3
Embodiment 1 to 5 resulting materials is carried out antibacterial experiment: concentration, at 121 DEG C of autoclaving 40min, is by all samples The bacterium solution of 107CFU/mL drops in the sample surfaces (0.06mL/cm of sterilizing2), then there is the sample of bacterium solution to put into 37 DEG C by dripping Constant incubator cultivates 24h.Take out the sample that 24h cultivates, be seeded in the agar plate containing culture medium by after bacterium solution doubling dilution On.Postvaccinal agar plate is put into 37 DEG C of constant incubators and is cultivated 24h, takes out what agar plate calculating was lived after the cultivation of 24h Bacterial population (with reference to standard GB/T/T4789.2).
Result shows, the material of the present invention has obvious antibacterial ability to escherichia coli, and its antibiotic rate reaches 99.5%； Also have obvious antibacterial ability to staphylococcus aureus, antibiotic rate reaches 98.45%.

Claims (1)

1. a biomedical metallic material, it is characterised in that: raw material includes in parts by weight: 9 parts of niobium powder, platinum powder 8 parts, titanium valve 7 parts, molybdenum powder 7 parts, cellulose nitrate 6 parts, triphenyl phosphate 8 parts, 7 parts of antioxidant, auxiliary antioxidant 8 parts, wollastonite fibre 5 Part, dibutyl tin mercaptides 7 parts, dibutyl phthalate 9 parts, triphenyl phosphite 8 parts, Hyaluronic Acid 7 parts, starch 8 parts, silicon Acid calcium 9 parts, 2-ethyl-4-methylimidazole 6 parts；The granularity of above-mentioned niobium powder, platinum powder, titanium valve and molybdenum powder is 200 mesh；
Above-mentioned antioxidant is the mixture of antioxidant 1010 and antioxidant 1076, wherein, and antioxidant 1010 and antioxidant 1076 Weight ratio is 3:2；
Above-mentioned auxiliary antioxidant is the double lauryl of thio-2 acid；
The preparation method of above-mentioned biomedical metallic material, comprises the following steps:
Step 1, adds to, in mixing and blending machine, be uniformly mixed by each component, and mixing speed is 400rpm, and mixing time is 20min, obtains mixed material；
Step 2, joins in reactor by step 1 gained mixed material, is heated to 80 DEG C in nitrogen atmosphere, stirring reaction 30min, obtains reactant；
Step 3, by extruded in step 2 gained reactant feeding double screw extruder, water-cooled, air-dried, pelletizing, obtains biological doctor With metal material, wherein the extrusion condition of double screw extruder is: district's temperature 200 DEG C, two district's temperature 220 DEG C, three district's temperature 230 DEG C, four district's temperature 250 DEG C, screw speed is 180rpm.
CN201610730219.6A 2014-11-07 2014-11-07 A kind of antibacterial ability and the preferable biomedical metallic material of decay resistance Withdrawn CN106267333A (en)

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