CN106237377A - Antibacterial ability and the preferable biomedical metallic material of decay resistance - Google Patents
Antibacterial ability and the preferable biomedical metallic material of decay resistance Download PDFInfo
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- CN106237377A CN106237377A CN201610725174.3A CN201610725174A CN106237377A CN 106237377 A CN106237377 A CN 106237377A CN 201610725174 A CN201610725174 A CN 201610725174A CN 106237377 A CN106237377 A CN 106237377A
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- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
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- C22C47/00—Making alloys containing metallic or non-metallic fibres or filaments
- C22C47/14—Making alloys containing metallic or non-metallic fibres or filaments by powder metallurgy, i.e. by processing mixtures of metal powder and fibres or filaments
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- A—HUMAN NECESSITIES
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
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- A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
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- A—HUMAN NECESSITIES
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A—HUMAN NECESSITIES
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/028—Other inorganic materials not covered by A61L31/022 - A61L31/026
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C49/00—Alloys containing metallic or non-metallic fibres or filaments
- C22C49/02—Alloys containing metallic or non-metallic fibres or filaments characterised by the matrix material
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- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C49/00—Alloys containing metallic or non-metallic fibres or filaments
- C22C49/14—Alloys containing metallic or non-metallic fibres or filaments characterised by the fibres or filaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Abstract
The invention provides a kind of antibacterial ability and the preferable biomedical metallic material of decay resistance, described metal material raw material includes niobium powder, platinum powder, titanium valve, molybdenum powder, cellulose nitrate, triphenyl phosphate, antioxidant, auxiliary antioxidant, wollastonite fibre, dibutyl tin mercaptides, dibutyl phthalate, triphenyl phosphite, Hyaluronic Acid, starch, calcium silicates and 2 ethyl 4 Methylimidazole .s.Its preparation method is for first to add in mixing and blending machine by each component, it is uniformly mixed, gained mixed material is joined in reactor, heated and stirred reaction in nitrogen atmosphere, by extruded in gained reactant feeding double screw extruder, water-cooled, air-dried, pelletizing, obtain biomedical metallic material.Gained biomedical metallic material not only hardness of the present invention and corrosion resistant performance have raising in various degree, and escherichia coli and staphylococcus aureus are respectively provided with good antibacterial ability, and its antibiotic rate respectively reaches 99.5% and 98.45%.
Description
Technical field
The invention belongs to biology medical material technical field, be specifically related to a kind of biomedical metallic material and preparation side thereof
Method.
Background technology
Bio-medical material refers to for medically implanting organism or the material combined with biological tissue, available
In diagnosis, treatment, and replace tissue, the organ in living organism or promote its function.It is currently used for the bio-medical of clinic
Material mainly includes biomedical metallic material, bio-medical organic material (referring mainly to high-molecular organic material), bio-medical
Inorganic Non-metallic Materials (referring mainly to bioceramic), bio-vitric and carbon materials and bio-medical composition etc..With life
Thing pottery and bioabsorbable polymer material are compared, biomedical metallic material, such as rustless steel, cobalt-base alloys, titanium and titanium alloy and
Noble metals etc. have the many such as high intensity, good toughness and counter-bending fatigue strength, excellent processing characteristics, and other are medical
The irreplaceable premium properties of material.
The subject matter that biomedical metallic material faces in the application, is the gold caused due to the corrosion of physiological environment
Belonging to ion to spread and the regression of embedded material self property to surrounding tissue, the former may cause toxic and side effects, and the latter may
Cause graft failure.Medical metal material as a class of biomaterial, its research and development strictly to meet as follows from life
Thing require: good histocompatibility, including avirulence, without heat source response, not teratogenesis, the most carcinogenic, do not cause allergic reaction
Or the immune mechanism of interference body, do not destroy adjacent tissue, the most the calcification on generating material surface is calm etc.;Good physics,
Chemical stability, including intensity, elasticity, dimensional stability, corrosion resistance, wearability and interface stability etc.;It is prone to processing
Molding, material is easily fabricated;Price is suitable.
Therefore, research and development performance is more excellent, and biocompatibility more preferable new bio medical metal material is material supplier
Author and the problem of medical personnel's common concern.
Summary of the invention
It is an object of the invention to overcome the deficiencies in the prior art to provide a kind of biomedical metallic material and preparation side thereof
Method, this material has good antibiotic property, mechanical property and decay resistance.
A kind of biomedical metallic material, raw material includes in parts by weight: niobium powder 3~9 parts, platinum powder 2~8 parts, titanium valve 1~
7 parts, molybdenum powder 2~7 parts, cellulose nitrate 1~6 parts, triphenyl phosphate 3~8 parts, antioxidant 1~7 parts, auxiliary antioxidant 2~
8 parts, wollastonite fibre 1~5 parts, dibutyl tin mercaptides 2~7 parts, dibutyl phthalate 3~9 parts, triphenyl phosphite 3
~8 parts, Hyaluronic Acid 2~7 parts, starch 1~8 parts, calcium silicates 2~9 parts, 2-ethyl-4-methylimidazole 1~6 parts.
As the further improvement of foregoing invention, the granularity of described niobium powder, platinum powder, titanium valve and molybdenum powder is 100~200 mesh.
As the further improvement of foregoing invention, described antioxidant is the mixture of antioxidant 1010 and antioxidant 1076,
Wherein, the weight ratio of antioxidant 1010 and antioxidant 1076 is 3:2.
As the further improvement of foregoing invention, described auxiliary antioxidant is the double lauryl of thio-2 acid.
The preparation method of above-mentioned biomedical metallic material, comprises the following steps:
Step 1, adds to, in mixing and blending machine, be uniformly mixed by each component, obtains mixed material;
Step 2, joins in reactor by step 1 gained mixed material, is heated to 65~80 DEG C in nitrogen atmosphere, and stirring is anti-
Answer 30~40min, obtain reactant;
Step 3, by extruded in step 2 gained reactant feeding double screw extruder, water-cooled, air-dried, pelletizing, obtains biological doctor
Use metal material.
As the further improvement of foregoing invention, the mixing speed being uniformly mixed in step 1 is 300~400rpm,
Mixing time is 20~40min.
As the further improvement of foregoing invention, in step 3, the extrusion condition of double screw extruder is: district's temperature 180
~200 DEG C, two district's temperature 200~220 DEG C, three district's temperature 210~230 DEG C, four district's temperature 230~250 DEG C, screw speed is
160~180rpm.
The biomedical metallic material of the present invention not only hardness and corrosion resistant performance have raising in various degree, and to greatly
Enterobacteria and staphylococcus aureus are respectively provided with good antibacterial ability, and its antibiotic rate respectively reaches 99.5% and 98.45%,
The requirement of the antibiotic property needed for biomedical metallic material, mechanical property and decay resistance can be met.
Detailed description of the invention
Embodiment 1
A kind of biomedical metallic material, raw material includes in parts by weight: 3 parts of niobium powder, platinum powder 2 parts, titanium valve 1 part, molybdenum powder 2 parts,
Cellulose nitrate 1 part, triphenyl phosphate 3 parts, 1 part of antioxidant, auxiliary antioxidant 2 parts, wollastonite fibre 1 part, dibutyl sulfide
2 parts of alcohol stannum, dibutyl phthalate 3 parts, triphenyl phosphite 3 parts, Hyaluronic Acid 2 parts, starch 1 part, calcium silicates 2 parts, 2-second
Base-4-methylimidazole 1 part.
The granularity of above-mentioned niobium powder, platinum powder, titanium valve and molybdenum powder is 100 mesh.
Above-mentioned antioxidant is the mixture of antioxidant 1010 and antioxidant 1076, wherein, and antioxidant 1010 and antioxidant
The weight ratio of 1076 is 3:2.
Above-mentioned auxiliary antioxidant is the double lauryl of thio-2 acid.
The preparation method of above-mentioned biomedical metallic material, comprises the following steps:
Step 1, adds to, in mixing and blending machine, be uniformly mixed by each component, and mixing speed is 300rpm, and mixing time is
40min, obtains mixed material;
Step 2, joins in reactor by step 1 gained mixed material, is heated to 65 DEG C in nitrogen atmosphere, stirring reaction
40min, obtains reactant;
Step 3, by extruded in step 2 gained reactant feeding double screw extruder, water-cooled, air-dried, pelletizing, obtains biological doctor
With metal material, wherein the extrusion condition of double screw extruder is: district's temperature 180 DEG C, two district's temperature 200 DEG C, three district's temperature
210 DEG C, four district's temperature 230 DEG C, screw speed is 160rpm.
Embodiment 2
A kind of biomedical metallic material, raw material includes in parts by weight: 4 parts of niobium powder, platinum powder 6 parts, titanium valve 2 parts, molybdenum powder 3 parts,
Cellulose nitrate 5 parts, triphenyl phosphate 6 parts, 2 parts of antioxidant, auxiliary antioxidant 5 parts, wollastonite fibre 4 parts, dibutyl sulfide
5 parts of alcohol stannum, dibutyl phthalate 8 parts, triphenyl phosphite 7 parts, Hyaluronic Acid 5 parts, starch 3 parts, calcium silicates 5 parts, 2-second
Base-4-methylimidazole 3 parts.
The granularity of above-mentioned niobium powder, platinum powder, titanium valve and molybdenum powder is 140 mesh.
Above-mentioned antioxidant is the mixture of antioxidant 1010 and antioxidant 1076, wherein, and antioxidant 1010 and antioxidant
The weight ratio of 1076 is 3:2.
Above-mentioned auxiliary antioxidant is the double lauryl of thio-2 acid.
The preparation method of above-mentioned biomedical metallic material, comprises the following steps:
Step 1, adds to, in mixing and blending machine, be uniformly mixed by each component, and mixing speed is 350rpm, and mixing time is
30min, obtains mixed material;
Step 2, joins in reactor by step 1 gained mixed material, is heated to 75 DEG C in nitrogen atmosphere, stirring reaction
35min, obtains reactant;
Step 3, by extruded in step 2 gained reactant feeding double screw extruder, water-cooled, air-dried, pelletizing, obtains biological doctor
With metal material, wherein the extrusion condition of double screw extruder is: district's temperature 190 DEG C, two district's temperature 210 DEG C, three district's temperature
220 DEG C, four district's temperature 240 DEG C, screw speed is 170rpm.
Embodiment 3
A kind of biomedical metallic material, raw material includes in parts by weight: 7 parts of niobium powder, platinum powder 3 parts, titanium valve 2 parts, molybdenum powder 3 parts,
Cellulose nitrate 5 parts, triphenyl phosphate 6 parts, 2 parts of antioxidant, auxiliary antioxidant 3 parts, wollastonite fibre 4 parts, dibutyl sulfide
6 parts of alcohol stannum, dibutyl phthalate 8 parts, triphenyl phosphite 5 parts, Hyaluronic Acid 4 parts, starch 3 parts, calcium silicates 7 parts, 2-second
Base-4-methylimidazole 2 parts.
The granularity of above-mentioned niobium powder, platinum powder, titanium valve and molybdenum powder is 160 mesh.
Above-mentioned antioxidant is the mixture of antioxidant 1010 and antioxidant 1076, wherein, and antioxidant 1010 and antioxidant
The weight ratio of 1076 is 3:2.
Above-mentioned auxiliary antioxidant is the double lauryl of thio-2 acid.
The preparation method of above-mentioned biomedical metallic material, comprises the following steps:
Step 1, adds to, in mixing and blending machine, be uniformly mixed by each component, and mixing speed is 400rpm, and mixing time is
20min, obtains mixed material;
Step 2, joins in reactor by step 1 gained mixed material, is heated to 80 DEG C in nitrogen atmosphere, stirring reaction
30min, obtains reactant;
Step 3, by extruded in step 2 gained reactant feeding double screw extruder, water-cooled, air-dried, pelletizing, obtains biological doctor
With metal material, wherein the extrusion condition of double screw extruder is: district's temperature 200 DEG C, two district's temperature 220 DEG C, three district's temperature
230 DEG C, four district's temperature 250 DEG C, screw speed is 180rpm.
Embodiment 4
A kind of biomedical metallic material, raw material includes in parts by weight: 5 parts of niobium powder, platinum powder 3 parts, titanium valve 6 parts, molybdenum powder 4 parts,
Cellulose nitrate 2 parts, triphenyl phosphate 6 parts, 4 parts of antioxidant, auxiliary antioxidant 7 parts, wollastonite fibre 3 parts, dibutyl sulfide
5 parts of alcohol stannum, dibutyl phthalate 8 parts, triphenyl phosphite 4 parts, Hyaluronic Acid 3 parts, starch 6 parts, calcium silicates 7 parts, 2-second
Base-4-methylimidazole 5 parts.
The granularity of above-mentioned niobium powder, platinum powder, titanium valve and molybdenum powder is 120 mesh.
Above-mentioned antioxidant is the mixture of antioxidant 1010 and antioxidant 1076, wherein, and antioxidant 1010 and antioxidant
The weight ratio of 1076 is 3:2.
Above-mentioned auxiliary antioxidant is the double lauryl of thio-2 acid.
The preparation method of above-mentioned biomedical metallic material, comprises the following steps:
Step 1, adds to, in mixing and blending machine, be uniformly mixed by each component, and mixing speed is 300rpm, and mixing time is
40min, obtains mixed material;
Step 2, joins in reactor by step 1 gained mixed material, is heated to 65 DEG C in nitrogen atmosphere, stirring reaction
40min, obtains reactant;
Step 3, by extruded in step 2 gained reactant feeding double screw extruder, water-cooled, air-dried, pelletizing, obtains biological doctor
With metal material, wherein the extrusion condition of double screw extruder is: district's temperature 180 DEG C, two district's temperature 200 DEG C, three district's temperature
210 DEG C, four district's temperature 230 DEG C, screw speed is 160rpm.
Embodiment 5
A kind of biomedical metallic material, raw material includes in parts by weight: 9 parts of niobium powder, platinum powder 8 parts, titanium valve 7 parts, molybdenum powder 7 parts,
Cellulose nitrate 6 parts, triphenyl phosphate 8 parts, 7 parts of antioxidant, auxiliary antioxidant 8 parts, wollastonite fibre 5 parts, dibutyl sulfide
7 parts of alcohol stannum, dibutyl phthalate 9 parts, triphenyl phosphite 8 parts, Hyaluronic Acid 7 parts, starch 8 parts, calcium silicates 9 parts, 2-second
Base-4-methylimidazole 6 parts.
The granularity of above-mentioned niobium powder, platinum powder, titanium valve and molybdenum powder is 200 mesh.
Above-mentioned antioxidant is the mixture of antioxidant 1010 and antioxidant 1076, wherein, and antioxidant 1010 and antioxidant
The weight ratio of 1076 is 3:2.
Above-mentioned auxiliary antioxidant is the double lauryl of thio-2 acid.
The preparation method of above-mentioned biomedical metallic material, comprises the following steps:
Step 1, adds to, in mixing and blending machine, be uniformly mixed by each component, and mixing speed is 400rpm, and mixing time is
20min, obtains mixed material;
Step 2, joins in reactor by step 1 gained mixed material, is heated to 80 DEG C in nitrogen atmosphere, stirring reaction
30min, obtains reactant;
Step 3, by extruded in step 2 gained reactant feeding double screw extruder, water-cooled, air-dried, pelletizing, obtains biological doctor
With metal material, wherein the extrusion condition of double screw extruder is: district's temperature 200 DEG C, two district's temperature 220 DEG C, three district's temperature
230 DEG C, four district's temperature 250 DEG C, screw speed is 180rpm.
Test example 1
Embodiment 1 to 5 resulting materials is carried out corrosion resistant performance test: test sample is that working electrode, graphite rod are for electrode, sweet
Mercury electrode is reference electrode, utilizes the corrosion resistant performance of electrochemical workstation (Shanghai occasion China CHI760C) test material, test voltage
For-2V~2V.
Result shows, the material of the present invention is for pure titanium, and corrosion potential all offsets to positive direction, shows the present invention
Material corrosion resistant ability strengthened, this existence being probably cellulose nitrate makes its corrosion resistant ability be improved.
Test example 2
Embodiment 1 to 5 resulting materials is carried out nano hardness test: (U.S.'s Mei Tesi process system has to utilize nano-hardness tester
Limit company), with continuous hardness test, material is carried out nano hardness test, triangle Buddha's warrior attendant cone pressure head is 1mN's at load force
Being 70nm at material surface compression distance under promotion, computer software records corresponding data simultaneously.The hardness number of sample is by surveying
Amount five zoness of different of sample obtain.
Result shows, the material of the present invention is for pure titanium, and nano-hardness value all improves more than 15%.
Test example 3
Embodiment 1 to 5 resulting materials is carried out antibacterial experiment: concentration, at 121 DEG C of autoclaving 40min, is by all samples
The bacterium solution of 107CFU/mL drops in the sample surfaces (0.06mL/cm of sterilizing2), then there is the sample of bacterium solution to put into 37 DEG C by dripping
Constant incubator cultivates 24h.Take out the sample that 24h cultivates, be seeded in the agar plate containing culture medium by after bacterium solution doubling dilution
On.Postvaccinal agar plate is put into 37 DEG C of constant incubators and is cultivated 24h, takes out what agar plate calculating was lived after the cultivation of 24h
Bacterial population (with reference to standard GB/T/T4789.2).
Result shows, the material of the present invention has obvious antibacterial ability to escherichia coli, and its antibiotic rate reaches 99.5%;
Also have obvious antibacterial ability to staphylococcus aureus, antibiotic rate reaches 98.45%.
Claims (1)
1. a biomedical metallic material, it is characterised in that: raw material includes in parts by weight: 5 parts of niobium powder, platinum powder 3 parts, titanium valve
6 parts, molybdenum powder 4 parts, cellulose nitrate 2 parts, triphenyl phosphate 6 parts, 4 parts of antioxidant, auxiliary antioxidant 7 parts, wollastonite fibre 3
Part, dibutyl tin mercaptides 5 parts, dibutyl phthalate 8 parts, triphenyl phosphite 4 parts, Hyaluronic Acid 3 parts, starch 6 parts, silicic acid
Calcium 7 parts, 2-ethyl-4-methylimidazole 5 parts;
The granularity of above-mentioned niobium powder, platinum powder, titanium valve and molybdenum powder is 120 mesh;
Above-mentioned antioxidant is the mixture of antioxidant 1010 and antioxidant 1076, wherein, and antioxidant 1010 and antioxidant 1076
Weight ratio is 3:2;
Above-mentioned auxiliary antioxidant is the double lauryl of thio-2 acid;
The preparation method of above-mentioned biomedical metallic material, comprises the following steps:
Step 1, adds to, in mixing and blending machine, be uniformly mixed by each component, and mixing speed is 300rpm, and mixing time is
40min, obtains mixed material;
Step 2, joins in reactor by step 1 gained mixed material, is heated to 65 DEG C in nitrogen atmosphere, stirring reaction
40min, obtains reactant;
Step 3, by extruded in step 2 gained reactant feeding double screw extruder, water-cooled, air-dried, pelletizing, obtains biological doctor
With metal material, wherein the extrusion condition of double screw extruder is: district's temperature 180 DEG C, two district's temperature 200 DEG C, three district's temperature
210 DEG C, four district's temperature 230 DEG C, screw speed is 160rpm.
Priority Applications (1)
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CN201610725174.3A CN106237377A (en) | 2014-11-07 | 2014-11-07 | Antibacterial ability and the preferable biomedical metallic material of decay resistance |
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CN201410623911.XA CN104436310B (en) | 2014-11-07 | 2014-11-07 | A kind of biomedical metallic material and preparation method thereof |
CN201610725174.3A CN106237377A (en) | 2014-11-07 | 2014-11-07 | Antibacterial ability and the preferable biomedical metallic material of decay resistance |
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CN201410623911.XA Division CN104436310B (en) | 2014-11-07 | 2014-11-07 | A kind of biomedical metallic material and preparation method thereof |
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CN201610725898.8A Pending CN106267372A (en) | 2014-11-07 | 2014-11-07 | A kind of biomedical metallic material |
CN201610725174.3A Withdrawn CN106237377A (en) | 2014-11-07 | 2014-11-07 | Antibacterial ability and the preferable biomedical metallic material of decay resistance |
CN201610741939.2A Expired - Fee Related CN106337155B (en) | 2014-11-07 | 2014-11-07 | The preferable biomedical metallic material of antibacterial ability |
CN201610730219.6A Withdrawn CN106267333A (en) | 2014-11-07 | 2014-11-07 | A kind of antibacterial ability and the preferable biomedical metallic material of decay resistance |
CN201410623911.XA Active CN104436310B (en) | 2014-11-07 | 2014-11-07 | A kind of biomedical metallic material and preparation method thereof |
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CN201610730219.6A Withdrawn CN106267333A (en) | 2014-11-07 | 2014-11-07 | A kind of antibacterial ability and the preferable biomedical metallic material of decay resistance |
CN201410623911.XA Active CN104436310B (en) | 2014-11-07 | 2014-11-07 | A kind of biomedical metallic material and preparation method thereof |
CN201610723368.XA Pending CN106178097A (en) | 2014-11-07 | 2014-11-07 | Preferable biomedical metallic material of antibacterial ability and preparation method thereof |
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CN101107067A (en) * | 2005-01-24 | 2008-01-16 | 金文申有限公司 | Metal-containing composite materials |
CN102046214A (en) * | 2008-01-04 | 2011-05-04 | 史密夫和内修有限公司 | Surface alloyed medical implant |
US20120070650A1 (en) * | 2010-09-16 | 2012-03-22 | Korea Institute Of Science And Technology | Biomedical implants comprising surface-modified metal particles and biodegradable polymers, its use for suppressing inflammation, and preparation method thereof |
CN103028146A (en) * | 2011-09-29 | 2013-04-10 | 深圳兰度生物材料有限公司 | Reinforcement medical composite material and method for preparing same |
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TWI287559B (en) * | 2002-08-22 | 2007-10-01 | Konica Corp | Organic-inorganic hybrid film, its manufacturing method, optical film, and polarizing film |
CN1735562A (en) * | 2003-01-17 | 2006-02-15 | 西巴特殊化学品控股有限公司 | A process for the production of porous inorganic materials or a matrix material containing nanoparticles |
CN100544776C (en) * | 2006-05-18 | 2009-09-30 | 上海交通大学 | Method for making foam biological titanium alloy artificial skelecton with hollow structure |
CN101165087B (en) * | 2006-10-17 | 2010-12-01 | 路德石油化工(北京)有限公司 | Nano composite biological degradation plastic and preparing method thereof |
CN101724764B (en) * | 2009-12-10 | 2011-07-20 | 中南大学 | Process for preparing biomedical beta-titanium alloy |
CN102964790A (en) * | 2012-11-19 | 2013-03-13 | 贵州鸿顺发建材科技有限公司 | Man-made stone basin and preparation method thereof |
CN103113129A (en) * | 2013-01-31 | 2013-05-22 | 华南理工大学 | Preparation method and application of hierarchical porous bioactive ceramic |
CN103788581B (en) * | 2014-02-08 | 2015-10-28 | 常州华森三维打印研究院有限公司 | 3D prints people's bone model medical material and preparation method thereof |
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CN101107067A (en) * | 2005-01-24 | 2008-01-16 | 金文申有限公司 | Metal-containing composite materials |
CN102046214A (en) * | 2008-01-04 | 2011-05-04 | 史密夫和内修有限公司 | Surface alloyed medical implant |
US20120070650A1 (en) * | 2010-09-16 | 2012-03-22 | Korea Institute Of Science And Technology | Biomedical implants comprising surface-modified metal particles and biodegradable polymers, its use for suppressing inflammation, and preparation method thereof |
CN103028146A (en) * | 2011-09-29 | 2013-04-10 | 深圳兰度生物材料有限公司 | Reinforcement medical composite material and method for preparing same |
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CN106178097A (en) | 2016-12-07 |
CN104436310B (en) | 2016-11-16 |
CN106267372A (en) | 2017-01-04 |
CN104436310A (en) | 2015-03-25 |
CN106267333A (en) | 2017-01-04 |
CN106337155A (en) | 2017-01-18 |
CN106337155B (en) | 2018-12-14 |
CN106334216A (en) | 2017-01-18 |
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