CN106266830A - A kind of Chinese medicine composition treating eczema - Google Patents
A kind of Chinese medicine composition treating eczema Download PDFInfo
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention discloses a kind of Chinese medicine composition treating eczema, it is that the raw material containing following weight proportioning is prepared from: Rhizoma Atractylodis 20 25 parts, Cortex Phellodendri 20 25 parts, Radix Sophorae Flavescentis 30 35 parts, Cortex Dictamni 30 35 parts, Rhizoma Smilacis Glabrae 30 35 parts, the Fructus Kochiae 30 35 parts, Fructus Cnidii 30 35 parts, Galla Chinensis 20 25 parts.Clinical trial certificate, pharmaceutical composition of the present invention is to eczema patients, and the especially anal eczema patient state of an illness is evident in efficacy, and toxic and side effects is little, has the advantage of uniqueness and preferable potential applicability in clinical practice.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition treating eczema.
Background technology
Eczema (eczema) is the high dermis and epidermal inflammation caused by multiple internal and external factor, and skin lesion is symmetrical, many
Weakened and emaciated body evil, violent pruritus, have and ooze out tendency, recurrent exerbation easily becomes chronic.
The pathogenesis of eczema is unclear.Internal factor can be by chronic infection focus, endocrine and metabolism change, blood
Circulatory disturbance, psychoneural factor, inherited genetic factors etc..Wherein inherited genetic factors is relevant with private medical service.External factor can be by losing
Mistake, inhalation (inhalatio), living environment, animal skin, various chemistry are induced or are increased the weight of.Some patient may be by delayed hypersensitivity
Mediation.
Western medical treatment eczema is with injection calcium preparation, vitamin C, sodium thiosulfate or procaine block, and secondary infection person adds
Use antibiotic.Local topical glucocorticoid boric acid solution etc., but all there is different side reactions, unsuitable life-time service, drug withdrawal
Rear easily recurrence.
Therefore, for eczema, need the most clinically more effectively, medicine that side effect is less.
Summary of the invention
For solving the problems referred to above, the invention provides a kind of Chinese medicine composition treating eczema, it is containing following weight
The raw material of proportioning is prepared from:
Rhizoma Atractylodis 20-25 part, Cortex Phellodendri 20-25 part, Radix Sophorae Flavescentis 30-35 part, Cortex Dictamni 30-35 part, Rhizoma Smilacis Glabrae 30-35 part, Fructus Kochiae
Sub-30-35 part, Fructus Cnidii 30-35 part, Galla Chinensis 20-25 part.
Further, it is the preparation being prepared from by the crude drug of following weight proportion:
Rhizoma Atractylodis 20-25 part, Cortex Phellodendri 20-25 part, Radix Sophorae Flavescentis 30-35 part, Cortex Dictamni 30-35 part, Rhizoma Smilacis Glabrae 30-35 part, Fructus Kochiae
Sub-30-35 part, Fructus Cnidii 30-35 part, Galla Chinensis 20-25 part.
Further, it is the preparation being prepared from by the crude drug of following weight proportion:
Rhizoma Atractylodis 20 parts, Cortex Phellodendri 20 parts, Radix Sophorae Flavescentis 30 parts, Cortex Dictamni 30 parts, Rhizoma Smilacis Glabrae 30 parts, the Fructus Kochiae 30 parts, Fructus Cnidii 30
Part, Galla Chinensis 20 parts.
Further, it is to be active component by the medicated powder of crude drug, the water of crude drug or extractive with organic solvent, adds
The preparation that adjuvant conventional in medicine or complementary composition are prepared from.
Further, described preparation is external preparation；Preferably, described external preparation is decoction, tincture, unguentum, gel
Agent, powder, liniment, paste or lotion.
The method that present invention also offers aforementioned Chinese medicine composition, it comprises the steps:
(1) each raw material is weighed by weight ratio；
(2) by described raw material extracting in water, extract of fetching water.
Further, in step (2), described extracting method is selected from decocting.
Present invention also offers aforementioned Chinese medicine composition purposes in the medicine of preparation treatment eczema.
Further, described eczema is anal eczema.
Further, described eczema is retention of damp-heat in the interior type eczema.
Clinical experiment shows, pharmaceutical composition of the present invention to eczema patients, especially anal eczema patient state of an illness curative effect
Significantly, toxic and side effects is little, has the advantage of uniqueness and preferable potential applicability in clinical practice.
Obviously, according to the foregoing of the present invention, according to ordinary technical knowledge and the customary means of this area, without departing from
Under the present invention above-mentioned basic fundamental thought premise, it is also possible to make the amendment of other various ways, replace or change.
The detailed description of the invention of form by the following examples, remakes the most specifically the foregoing of the present invention
Bright.But this should not being interpreted as, the scope of the above-mentioned theme of the present invention is only limitted to Examples below.All based on foregoing of the present invention
The technology realized belongs to the scope of the present invention.
Detailed description of the invention
The preparation of embodiment 1 medicine of the present invention
1, prescription: Rhizoma Atractylodis 20g, Cortex Phellodendri 20g, Radix Sophorae Flavescentis 30g, Cortex Dictamni 30g, Rhizoma Smilacis Glabrae 30g, Fructus Kochiae 30g, Fructus Cnidii
30g, Galla Chinensis 20g.
2, take each raw material of recipe quantity, soak about 30 minutes after first adding clear water 1000mL stirring before decoction, decoct 2 times,
First boiling rear slow fire (slow fire) with intense fire (very hot oven) and keep boil condition, start timing and decoct 30 minutes when boiling, second decocts
20 minutes, extracting juice about 300mL.
Using method: add clear water and boil, first smokes affected part, soak again after water temperature is suitable, immersion affected part, the most each 1 time.
The preparation of embodiment 2 medicine of the present invention
1, prescription: Rhizoma Atractylodis 20g, Cortex Phellodendri 20g, Radix Sophorae Flavescentis 30g, Cortex Dictamni 30g, Rhizoma Smilacis Glabrae 30g, Fructus Kochiae 30g, Fructus Cnidii
30g, Galla Chinensis 20g.
2, take each raw material of recipe quantity, soak about 30 minutes after first adding clear water 1000mL stirring before decoction, decoct 2 times,
First boiling rear slow fire (slow fire) with intense fire (very hot oven) and keep boil condition, start timing and decoct 30 minutes when boiling, second decocts
20 minutes, extracting juice about 300mL.
Using method: add clear water and boil, first smokes affected part, soak again after water temperature is suitable, immersion affected part, the most each 1 time.
Beneficial effects of the present invention is proved below by way of concrete test example.
Test example 1 clinical case is added up
(1) patient criteria's (or diagnostic criteria) is accepted for medical treatment
Gender and the range of age: patient 90 example, in age 18-65 year, women 39 example, male 51 example, total course of disease is the shortest by 2
Month, the longest 2 years, treatment time in the shortest January, the longest half a year.
Diagnostic criteria:
Acute pruritus, pleomorphism, symmetry skin lesion, acute stage has oozes out tendency, chronic phase lichenification skin lesion.General point
For acute eczema, subacute eczema, chronic eczema.
Acute eczema is apt to occur in the exposure portion such as face, ear, hands, foot, forearm, shank, and severe patient can fill the air whole body, often symmetrical
Distribution.Skin lesion pleomorphism, often shows as the syringe needle on the basis of erythema and may occur in which little to foxtail millet grain size pimple, papulovesicle, severe patient
Vesicle, permelting answer print, indefinite border Chu, skin lesion periphery papulovesicle is the most sparse, and Chang Yin scratches and forms point-like erosion face, has bright
Aobvious serosity is oozed out.Conscious acute pruritus, scratch, hot water laundering time can increase the weight of skin lesion.
Subacute eczema is to alleviate because of acute eczema inflammation or after inappropriate process, the course of disease develops more for a long time.Show as red
Swelling and ooze out and alleviate, but still can have pimple and a small amount of papulovesicle, skin lesion becomes kermesinus, can have a little squama and mild infiltration.Still
Conscious have violent pruritus.It is again exposed to sensitinogen, new stimulation or deals with improperly and may result in acute attack, not healing as prolonged,
Then can develop into chronic eczema.
Chronic eczema is to be delayed by acute eczema or subacute eczema, it is possible to owing to stimulation is slight, lasting, one opens
Begin to will appear as chronicity.It is apt to occur in brothers' shank fossa cubitalis thigh breast, pudendum, anus etc., symmetry is fallen ill.Show as suffering from
Having pimple, scratch and squama on the dark red speckle of portion's skin infiltration, local skin is plump, rough surface, has lichen sample in various degree
Become, pigmentation obtains hypopigmentation.Conscious have obvious pruritus, often in paroxysmal.During the state of an illness light time weight, continue the several months or more long.
(2) treatment standard
(1) the improvement EASI point system of proposition is distinguished with reference to Zhao, with regard to erythema, hard swollen (edema)/pimple, exfoliation, lichen
Change, ooze out/form a scab the curative effect before and after five comparison of items are tested.Concrete grammar is as follows:
E: erythema one redness or the struvite speckle of kermesinus, fading of pressure；
I: hard swollen (edema)/pimple one skin lesion is for having pinhead-sized pimple or mound big gun rash, or the red speckle of protuberance；
The epidermis injury that Ex: exfoliation one is scratched, is included on keratinization skin lesion the wire erosion chapped and on skin lesion；
L: lichenization one skin lesion is infiltration plumpness, hyperkeratosis.
Ef: ooze out/form a scab a skin lesion surface wettability, is crazy about including the dried knot of sepage.
The order of severity of every clinical manifestation with 0～3 point of score, 0=without, 1=is light, in 2=, 3=weight.Various symptoms are divided
Half fraction can be remembered between value, i.e. 0.5 0.
Clinical surface area size scoring: it is 1% estimation that skin lesion size calculates with patient's palm.Skin lesion area accounts for face, each position
Long-pending ratio score value is 0～6, and i.e. 0 is without erythra, 1 be < 10%, 2 is 10%～19%, and 3 is 20～49%, 4 be 50～
69%, it is 70～89%, 6 is 90～100%.Due to more than 8 years old human body, upper limb accounted for human body 20% respectively with the surface area of lower limb
And 40%, therefore in comparing upper limb and lower limb during outside, upper limb is outer, score x0.1 of inner side respectively, lower limb are outer, the score of inner side
X0.2, compares to facilitate.
Therapeutic evaluation: according to the change of EASI scoring before and after treatment, by " curative effect=(comment after scoring one treatment before treatment
Point)/treatment front scoring x 100% " calculate.Recovery from illness: curative effect >=90%；Effective: 90% > curative effect >=50%；Effective: 50% ＞ treats
Effect >=30%；Invalid: curative effect < 30%.
(2) degree of scratching where it itches is marked with following scale:
0 point: without any pruritus；
1 point: pruritus once in a while, it is not necessary to medication, do not affect learning life；
2 points: paroxysmal pruritus, time light time weight, affect sleep learning live；
3 points: acutely pruritus, have a strong impact on work and study life.
Between various symptom score can one note half fraction, i.e. 0.5.
(3) ((DLQI) assessment treatment is to patients ' life quality to use dermatology life quality index application form.
(3) Therapeutic Method
1, medication: after clarifying a diagnosis, 90 example patients all use following medicine: Rhizoma Atractylodis 20g, Cortex Phellodendri 20g, Radix Sophorae Flavescentis 30g,
Cortex Dictamni 30g, Rhizoma Smilacis Glabrae 30g, Fructus Kochiae 30g, Fructus Cnidii 30g, Galla Chinensis 20g.
Every day 1 dose, decocting 3 times, early, each 1 smoked affected part in evening, soak again after water temperature is suitable, soaks affected part, is used in conjunction 2 weeks.Control
During treatment, it be not furnished with other Western medicine and other therapies.
During treatment, diet is light, avoids delicious food savoury, avoids sweet food, seafood food and hot fruit, advises polyphagia vegetable.Avoid heat
Having one's hair waved is washed, and avoids these disease things such as soap and washes affected part.Avoid scratching, to prevent from infecting.
2, without obvious medication taboo, insensitivity skin person.
(4) therapeutic outcome
Treatment time: 2 weeks
Efficacy determination: result is as shown in table 1 below.
Table 1 90 example patient curative effect after treatment in 2 weeks
| Therapeutic outcome | Case load (example) | Effective percentage (%) |
| Recovery from illness | 22 | 24.4% |
| Effective | 30 | 33.3% |
| Effectively | 31 | 34.5% |
| Invalid | 7 | 7.8% |
| Amount to | 90 | 92.2% |
Visible, the medicine effective percentage of the present invention is high, can effectively treat eczema.
Untoward reaction: having no untoward reaction during medication, after the treatment of accidental some patients, skin is micro-red, advises patient to note water
Condition improved after temperature.Some patients is had a blood test as, hepatic and renal function is without exception.
Rhizoma Atractylodis, Cortex Phellodendri, Radix Sophorae Flavescentis in side, be the medicine that bitter cold is dried, and to drive away primary disease chief culprit's damp, damp must be gone then
The most touching difficulty of disease is more.Cortex Dictamni dispel the wind solution noxious dampness and antipruritic.Rhizoma Smilacis Glabrae, the Fructus Kochiae, Fructus Cnidii removing dampness to relieve itching, Galla Chinensis is received
Puckery is main, the skin lesion of astringent therapy ulceration, promotes healing.Full side focuses on dehumidifying, then with wind medicine dispelling wind for relieving itching, wet go to itch only the state of an illness to
More.
(5) model case
Patient Lee, male, 67 years old.Patient is with before 2 years, and pruritis occurs in podex, occurs that flushing is rotten to the corn after scratching
Face and sepage, give being coated with outside PIYANPING can respite, but often recur after a few days, touching difficulty is more.Quarter examines: crissum skin of buttock
Ulceration, wound surface flushing, there are crack, incrustation, a little sepage, red tongue, thick fur is greasy, rapid pulse.It is retention of damp-heat in the interior type after diagnosing.Control preferably
Heat clearing and damp drying.Using the specific implementation method of the present invention, and advise that patient keeps affected part to be dried, diet is light, avoids delicious food savoury,
Avoid sweet food, seafood food and hot fruit.By above-mentioned treatment 1 course for the treatment of, skin lesion reduces, and pruritus alleviates, and ulceration wound surface almost heals；
Again after medication 1 course for the treatment of, skin lesion, pruritus disappear.
Above-mentioned experiment shows, pharmaceutical composition of the present invention to eczema patients, especially anal eczema patient state of an illness curative effect
Significantly, toxic and side effects is little, has the advantage of uniqueness and preferable potential applicability in clinical practice.
Claims (10)
1. the Chinese medicine composition treating eczema, it is characterised in that: it is that the raw material containing following weight proportioning is prepared from:
Rhizoma Atractylodis 20-25 part, Cortex Phellodendri 20-25 part, Radix Sophorae Flavescentis 30-35 part, Cortex Dictamni 30-35 part, Rhizoma Smilacis Glabrae 30-35 part, Fructus Kochiae 30-
35 parts, Fructus Cnidii 30-35 part, Galla Chinensis 20-25 part.
Chinese medicine composition the most according to claim 1, it is characterised in that: it is to be prepared by the crude drug of following weight proportion
Preparation:
Rhizoma Atractylodis 20-25 part, Cortex Phellodendri 20-25 part, Radix Sophorae Flavescentis 30-35 part, Cortex Dictamni 30-35 part, Rhizoma Smilacis Glabrae 30-35 part, Fructus Kochiae 30-
35 parts, Fructus Cnidii 30-35 part, Galla Chinensis 20-25 part.
Chinese medicine composition the most according to claim 1, it is characterised in that: it is to be prepared by the crude drug of following weight proportion
Preparation:
Rhizoma Atractylodis 20 parts, Cortex Phellodendri 20 parts, Radix Sophorae Flavescentis 30 parts, Cortex Dictamni 30 parts, Rhizoma Smilacis Glabrae 30 parts, the Fructus Kochiae 30 parts, Fructus Cnidii 30 parts, five
Gall nut 20 parts.
4. according to the Chinese medicine composition described in claims 1 to 3 any one, it is characterised in that: it be by the medicated powder of crude drug,
The water of crude drug or extractive with organic solvent are active component, add in medicine conventional adjuvant or the preparation of complementary composition and
The preparation become.
5. according to the Chinese medicine composition described in Claims 1 to 4 any one, it is characterised in that: described preparation is external preparation；
Preferably, described external preparation is decoction, tincture, unguentum, gel, powder, liniment, paste or lotion.
6. prepare the method for Chinese medicine composition described in Claims 1 to 5 any one for one kind, it is characterised in that: it includes as follows
Step:
(1) each raw material is weighed by weight ratio；
(2) by described raw material extracting in water, extract of fetching water.
Method the most according to claim 6: in step (2), described extracting method is selected from decocting.
8. the purposes in the medicine of preparation treatment eczema of the Chinese medicine composition described in Claims 1 to 5 any one.
Purposes the most according to claim 9, it is characterised in that: described eczema is anal eczema.
Purposes the most according to claim 8 or claim 9, it is characterised in that: described eczema is retention of damp-heat in the interior type eczema.
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| CN106692817A (en) * | 2017-02-17 | 2017-05-24 | 成都风靡生物科技有限公司 | Ointment medicine for treating eczematous dermatitis and preparation method thereof |
| CN107184703A (en) * | 2017-06-06 | 2017-09-22 | 上海市中医医院 | A kind of three sub- anti-itching lotions and its preparation technology and application |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106692817A (en) * | 2017-02-17 | 2017-05-24 | 成都风靡生物科技有限公司 | Ointment medicine for treating eczematous dermatitis and preparation method thereof |
| CN107184703A (en) * | 2017-06-06 | 2017-09-22 | 上海市中医医院 | A kind of three sub- anti-itching lotions and its preparation technology and application |
| CN108283620A (en) * | 2018-03-13 | 2018-07-17 | 兆科药业（广州）有限公司 | A kind of local medicine composition of inhibitors of phosphodiesterase-4 and preparation method thereof |
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Application publication date: 20170104 |