CN106264855B - A kind of device for treating cornea tissue disease - Google Patents
A kind of device for treating cornea tissue disease Download PDFInfo
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- CN106264855B CN106264855B CN201610895446.4A CN201610895446A CN106264855B CN 106264855 B CN106264855 B CN 106264855B CN 201610895446 A CN201610895446 A CN 201610895446A CN 106264855 B CN106264855 B CN 106264855B
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
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- A61N5/067—Radiation therapy using light using laser light
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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- A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
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- A61M2230/00—Measuring parameters of the user
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Abstract
A kind of device for treating cornea tissue disease, including：Central processing unit；Light-source system in pairs is arranged in laser group, including ultraviolet laser and green (light) laser, the two parallel；Tunable optical component group according to set patterns by the light source of laser group makes the desired effect for reaching cross-linking reaction on irradiation surface；Closed chamber is internally provided with for adsorbing ocular tissue's surrounding skin to fix the suction ring of art eye；Oxygen feedway, for conveying oxygen into closed chamber；Solution instills absorption plant, and for importing the drug containing photosensitizer to art eye surface, photosensitizer is using riboflavin and the red component mixed in proportion of tiger；Observed result for being observed in real time cornea therapy situation, and is transmitted to central processing unit and handled by measuring system.The device can greatly improve the efficiency of the effect and treatment for the treatment of cornea tissue disease.
Description
Technical field
The present invention relates to the Medical Devices for the treatment of eye disease, especially a kind of dresses for treating cornea tissue disease
It sets.
Background technology
Keratoconus is one kind with kerectasis, a kind of central thinning ophthalmology disease for protruding forward, being characterized in cone
Disease.Can be unilateral side can also bilateral, usual puberty is high disease stage, can generally stop developing between 30 years old to 40 years old.
Its incidence is 0.05% or so.It, which can give, causes that patient's is ametropia, the damage of severe patient's eyesight.From the nineties in last century,
By ultraviolet light emulsion such as riboflavin, tissue can be promoted to be crosslinked this technology and be applied to the treatment of keratoconus and worked as
In, it has been extremely improved the effect for treating this disease.
But traditional therapeutic equipments and therapy, which is all unable to system, comprehensively refines this therapeutic process, is primarily present
Following problem：
1, excessively single for the control of laser, unconverted irradiation for a long time cannot reach crosslinked desired effect.
2, the light source selection of laser is excessively single, cannot introduce other visible lights and treat, to reduce in treatment to suffering from
The injury of person and doctor.
3, corneal thickness can not be treated directly less than 400 μm, direct irradiation can damage ocular tissue.
4, in terms of the importing of drug, in such a way that traditional syringe instills, the assimilation effect to drug is not
Very well, lack to ambient enviroment oxygen concentration, the controls such as temperature.
5, for cornea therapy situation cannot there are one the real-time observation methods of simple possible.
6, the system and data established are not complete enough, lack to be directed to different patients over the course for the treatment of and design and implement personalization
Therapeutic scheme.
Invention content
It is a kind of for treating cornea tissue disease it is a primary object of the present invention to overcome the deficiencies of the prior art and provide
Device greatly improves the effect for the treatment of and the efficiency for the treatment of.
To achieve the above object, the present invention uses following technical scheme：
A kind of device for treating cornea tissue disease, including：
Central processing unit；
Laser group, including ultraviolet laser and green (light) laser, the two are arranged light-source system in pairs parallel, when work
The central processing unit, which first controls, opens the green (light) laser, controls unlatching again when the mechanics parameter of measurement does not change
The ultraviolet laser continues to irradiate；
Tunable optical component group, for the light source of laser group being sent to art eye surface according to the light pattern of setting and can be by
The central processing unit control, is adjusted the irradiation of laser, so as to reach the desired effect of cross-linking reaction on irradiation surface；
Closed chamber is internally provided with for adsorbing ocular tissue's surrounding skin to fix the suction ring of art eye；
Oxygen feedway is supplied oxygen for conveying oxygen into the closed chamber for cross-linking reaction；
Solution instills absorption plant, and for importing the drug containing photosensitizer to art eye surface, photosensitizer uses riboflavin
With the red component mixed in proportion of tiger, to generate cross-linking reaction in oxygen under ultraviolet light and green light irradiation；
Observed result for being observed in real time cornea therapy situation, and is transmitted to the centre by measuring system
Reason device is handled.
Further：
Make the indoor suction of the closing chamber for carrying out forvacuum processing to the closed chamber including vacuum plant
Ring adsorbs the skin around ocular tissue, while also promoting the indoor air discharge of the closing chamber to improve in the closed chamber
Oxygen shared by ratio.
The wavelength for the green light that the green (light) laser is sent out irradiates the energy density model on surface within the scope of 532 ± 10nm
It encloses for 0-0.50W/cm2, the diaphragm diameter for irradiating surface is 8-15mm at a distance from 1-1.5cm, with irradiation surface；It is described ultraviolet
The ultraviolet wavelength that light laser is sent out irradiates the energy density ranging from 0-100mW/ on surface within the scope of 365 ± 10nm
cm2, irradiation surface diaphragm diameter is in 7-13mm, with irradiation surface distance 8-15mm, it is preferable that the ultraviolet laser fortune
The row time reaches the predetermined time and automatically powers off, and when more preferable 10min automatically powers off.
Ultraviolet laser is corresponded in the tunable optical component group and green (light) laser respectively includes that driver can be passed through
First optical element of adjusting, the second optical element, laser amplitude device, the first beam-splitter, the second beam-splitter, reflecting plate, third
Beam-splitter, first optical element, second optical element, the reflecting plate, the third beam-splitter, the laser tune
Width device can be translated and rotated in light path by driver control；The light that the ultraviolet laser comes out is by first optics member
Part, second optical element, to form the aperture that energy density and diameter are suitble to；By first optics member
Part, second optical element a light part reflected by first beam-splitter, another part pass through first beam-splitter
Afterwards, the speculum is partly reflected by second beam-splitter, passes through the third beam-splitter again through speculum reflection
Reflection finally meets at main optical path with the light by first beam-splitter reflection, and two-way light is overlapped mutually, when the phase of two-way light
Strip interference fringe is formed on irradiation surface when position differs the integral multiple of some fixed numbers, by adjusting first light splitting
The movement and rotation of plate, second beam-splitter, the reflecting plate, the third beam-splitter, are formed by strip interference fringe
It can be moved in irradiation area；The laser amplitude device makes the energy density on irradiation surface exist for regulating and controlling the energy on irradiation surface
In the required range for the treatment of.
The tunable optical component group further includes being placed in where first optical element and second optical element
Light path on Darman raster element, with irradiation surface formed laser dot-matrix pattern, or using irradiation surface generate ring
The optical diffraction device of shape pattern.
The measuring system includes pressure sensor and oxygen atom detector, and the pressure sensor and the oxygen atom are visited
Device is surveyed to be used to send the numerical value of the indoor pressure value of the closing chamber and concentration of oxygen atoms to central processing unit, the centre
Reason device adjusts the oxygen output of the oxygen feedway by controlling solenoid valve.
The solution instills absorption plant and includes electro-ionic osmosis device, photosensitizer injection device, infrared heater and surpass
Sound drug introducing apparatus；The electro-ionic osmosis device includes the netted or spiral helicine electro-ionic osmosis electrode for being attached to eyeball surface
Piece；The photosensitizer injection device includes by the atomizer on liquid ultrasonic atomized spray to cornea, it is preferable that described photosensitive
The heating rod or resistance wire for heating photosensitizer are set in agent injection device, more preferably control temperature at 35 DEG C -40 DEG C；
The ultrasonic medicinal introducing apparatus applies ul-trasonic irradiation to increase absorption of the eyes to photosensitizer to photosensitizer；The infrared ray adds
Hot device irradiates cornea over the course for the treatment of, to form the temperature field of anterior corneal surface.
The measuring system includes optical measurer, ultrasonic meter, charge coupled cell, temperature sensor；It is described
The light that optical measurer detection is returned from irradiation surface reflection, so that central processing unit calculates dress according to detection optical signal prosessing
Set the distance and angle and corneal thickness of anterior corneal surface, it is preferable that the optical measurer is furnished with independent illumination unit
Independently to measure the thickness of cornea；The ultrasonic meter sends out ultrasonic wave to irradiation surface, receives the ultrasound of return
Signal is simultaneously transmitted to the central processing unit, to calculate the variation of the parameters such as anterior corneal surface regionality elasticity modulus；The electricity
Optical signal and processing in lotus coupling element light path are converted into electric signal and are transmitted to the central processing unit, to calculate light extraction
According to intensity；The temperature sensor detects anterior corneal surface temperature and is transmitted to central processing unit.
The measuring system includes visual pursuit measuring instrument, and the visual pursuit measuring instrument observes non-art eye, to non-art eye
Surface carries out the capture of corneal center, and the central processing unit is according to described in the adjusting of the observed case of the visual pursuit measuring instrument
Tunable optical component group is to control irradiating angle and distance of the treatment light path for art eye.
Further include the film that thickens with biocompatibility for being attached to anterior corneal surface, the film that thickens is the preferred sheep of natural membranes
Film or the preferred electrostatic spinning biofilm of artificial bio-membrane's film, drug, light, oxygen can penetrate described thicken needed for film arrival
Surface to be treated.
The inner surface for thickening film lays the microsensor of light transmission, for measure include ocular surface pressure,
One or more parameters in photosensitizer concentration, oxygen concentration, cornea mechanical property, and it is transmitted to central processing unit, it is preferable that institute
It states and thickens the inner surface of film and be also equipped with micro radio circuit, central processing unit is transferred data to by wireless transmission.
Beneficial effects of the present invention have：
In the embodiment of the present invention, ultraviolet light and green light irradiation are penetrated into the anterior corneal surface of photosensitizer, production by laser group
Biochemical cross-linking reaction, to enhance the mechanical property of cornea.The present invention is improved the radiation modality of light source and light, will be single
One replacing light source is ultraviolet light and green light, preferably adopts the radiation modality for the dot matrix for gathering around raster pattern.Using oxygen as protection gas, with
Enhance the concentration of the oxygen of chemical crosslinking.And using the method for chemical spray and ultrasonic delivery drug.Not for corneal thickness
Microsensor is preferably attached to preferably by film is thickened with auxiliary treatment and thickens film by the situation in direct therapeutic domain
On measuring the variation of the parameters such as cornea mechanical property.The embodiment of the present invention cornea can be carried out it is accurate, personalized, can
The treatment of adjustment.The device of embodiment can greatly improve the efficiency of the effect and treatment for the treatment of cornea tissue disease.
The advantages of specific embodiment of the invention, is embodied in：
1. using double light-source systems, green light (such as 532nm wavelength) is combined with ultraviolet light (such as 365nm wavelength) to be crosslinked,
Wherein green light is small to the damage of eyes, can suitably reduce the irradiation time of ultraviolet light, to reduce ultraviolet light to patient and doctor
Injury.
2. dot matrix laser is introduced, the variable illuminating method of figure laser, grating, the position tune that can be irradiated as needed
The shape of whole laser optimizes cross-linking reaction.
3. having used oxygen as protection gas and providing vacuum plant auxiliary adjustment concentration.
4. using ultrasonic delivery drug, the infiltration capacity of drug is improved.
5. using the irradiation of infrared ray to the heating for the treatment of surface in therapeutic process, while with electrically heated rod or resistance wire pair
It needs the drug injected to be heated, accelerates the progress for the treatment of.
6. the patient for cornea patient especially thickness less than 400 μm uses a kind of good biology of biocompatibility
Film is fitted in eyeball surface auxiliary treatment, and has microsensor that can transfer data in server inside it and carry out directly
The data transmission connect.
7. the photosensitizer for the treatment of is using riboflavin and the red drug mixed in proportion of tiger, solution can be in lower progress of not sharing the same light
Cross-linking reaction.
8. being heated to treatment surface using infrared ray, the temperature field on control treatment surface.
9. the comparative analysis strategy of big data can be used, analogy, simulation are carried out to the patient data treated by this method
Go out corresponding treatment strategy, treated, over the course for the treatment of, constantly generates correction data, it is right in the range of safety allows
The dosage for the treatment of is adjusted.And database can be constantly updated, the details that patient treats in archives will be transmitted to total clothes
It is analyzed in business device, keeps the information of successive treatment more comprehensive.
The embodiment of the present invention, which compares the prior art, has following clear superiority：
1. in such a way that double light-source systems are combined, therapeutic effect can be enhanced by increasing green light, and can be corresponding
The irradiation time of ultraviolet light is reduced, reduces and patient and doctor is injured, reduces Operative risk.
2. the variable radiation modality of dot matrix laser, figure laser, grating can effectively comply with crosslinked mechanical periodicity, make
Time that each reactant concentration reacts is chemically reacted by chance in the best time.
3. oxygen can be adjusted as the amount of reactant by the way that purity oxygen is added, while use a small-sized pumping
Vacuum carries out forvacuum processing to closed chamber, makes on the skin that the suction ring of closed chamber is adsorbed on around ocular tissue, together
When the indoor air of chamber can be discharged, improve the ratio shared by chamber indoor oxygen, oxygen forms work under the irradiation of ultraviolet light
Property oxygen atom, accelerates the progress of chemical crosslink reaction.
4. ultrasonic wave promotes drug to penetrate into cornea, it is rapidly achieved affected part.
5. a pair affected part is heated with mid-infrared light, this laser is comparatively safe to eyes, can improve therapentic part
Temperature accelerates the reaction for the treatment of to carry out.
6. good using a kind of biocompatibility less than 400 μm of patient for cornea patient especially corneal thickness
Biomembrane be fitted in eyeball surface, the effective injury for controlling ultraviolet light to the other tissues of eye.Biomembrane can be natural
Amnion, can also be the artificial electrostatic spinning biofilm of tailored thicknesses.The sensor on its surface can pass many kinds of parameters
It is sent to central processing unit, forms direct data transmission.
7. the indoor pressure of closing chamber can be adjusted by the supply amount of solenoid valve control oxygen, when needing measurement one
When the mechanics parameter of a little corneas, the indoor pressure of chamber can change, and by obtaining feedback signal of the ultrasonic wave to ocular tissue, count
Calculate the parameters such as the elasticity modulus of cornea.
8. use infrared ray carries out Temperature Field Control to treatment surface, accelerate the progress of cross-linking reaction.
9. the related data of the initial data before patient's treatment, real-time measuring data and hospital in therapeutic process is one
The database of continuous renewal, the data such as the thickness of cornea, the mechanical property of cornea, ultraviolet irradiation amount, riboflavin usage amount
The Active treatment algorithm for constituting a various dimensions, to automatically adjust dosage and intensity of illumination according to treatment stage, this can
Being completed under the control of doctor, provide it is a kind of based on the therapeutic scheme of real data for doctor select.This safety
Control can be established according to the clinical case of big data and improve medical data base, and being multiplied by related coefficient with safest data obtains
The most reasonable approach for the treatment of.
Description of the drawings
Fig. 1 is the system diagram for the device that the embodiment of the present invention is suitable for treating cornea tissue disease.
Fig. 2 is the variation structure for the crosslinking apparatus illumination system that the embodiment of the present invention is suitable for personalized treatment cornea tissue
Figure.
Fig. 3 is the variation structure chart that the embodiment of the present invention calibrates irradiation system.
Fig. 4 is the variation structure chart of cornea heating device of the embodiment of the present invention.
Fig. 5 is the schematic diagram of the double light source laser therapies of the embodiment of the present invention.
Fig. 6 is the schematic diagram that laser irradiation of the embodiment of the present invention forms grating.
Fig. 7 is the schematic diagram that laser of the embodiment of the present invention forms dot matrix.
Fig. 8 is the schematic diagram of ul-trasonic irradiation drug of the embodiment of the present invention.
Fig. 9 is schematic diagram of the embodiment of the present invention by voltage difference electro-ionic osmosis.
Figure 10 is that the embodiment of the present invention passes through the schematic diagram of ultrasonic measurement cornea mechanical property under gas pressure.
Figure 11 is that cornea of the embodiment of the present invention thickens the schematic diagram that film is combined with microsensor.
Figure 12 is the flow chart of Individualized computer of embodiment of the present invention treatment.
Reference sign：
0- eyes (art eye), 0 '-non-art eye, 1- central processing units, 2- closed chambers, 3- optical measurers, 4- operations are flat
Platform, 5- ultraviolet lasers, 6- vacuum plants, 7- ultrasonic meters, 8- electro-ionic osmosis device, 9- oxygen storage tank, 10- electricity
Lotus coupling element, the first optical elements of 11-, the second optical elements of 12-, 13- laser amplitudes device, the first beam-splitters of 14-, 15-
Two beam-splitters, 16- reflecting plates, 17- thirds beam-splitter, 18- temperature sensors, 19- pressure sensors, 20- oxygen atoms detector,
21- photosensitizers injection device, 22- normal saline flushings device, 23- Darman rasters element, 24- drivers, 25- visual pursuits are surveyed
Amount instrument, 26- infrared heaters, 27- electro-ionic osmosis electrode slice, 28- thicken film, 29- microsensors, 30- green (light) lasers,
31- ultrasounds import medicinal therapy instrument, 41- irradiation lights, 42- strips interference fringe, 43- laser dot-matrixes pattern, 44- ultrasonic signals, 45-
Oxygen.
Specific implementation mode
It elaborates below to embodiments of the present invention.It is emphasized that following the description is only exemplary,
The range being not intended to be limiting of the invention and its application.
Refering to fig. 1 to Figure 10, in one embodiment, a kind of device for treating the cornea tissue disease of eyes 0 is fitted
For personalized treatment cornea tissue disease, the device mainly includes：Laser group, tunable optical component group, central processing unit
1, closed chamber 2, oxygen feedway, solution instill absorption plant, measuring system, vacuum plant 6 etc..The device can pass through spy
Fixed closed-loop control system measures the real-time parameter of cornea, to be directed to different phase, cornea of different nature, imposes different
Photosensitizer doses, illumination type, intensity of illumination etc. are crosslinked purpose to reach expected.
Laser group preferably includes ultraviolet laser 5 and green (light) laser 30, can be adjusted by driver 24 adjustable
Ultraviolet laser is corresponded in optical element group and green (light) laser respectively includes the first optical element 11, the second optical element
12, laser amplitude device 13, the first beam-splitter 14, the second beam-splitter 15, reflecting plate 16, third beam-splitter 17, oxygen feedway
Including oxygen storage tank 9, it includes electro-ionic osmosis device 8, photosensitizer injection device 21, physiological saline punching that solution, which instills absorption plant,
Cleaning device 22, infrared heater 26 thicken film 28, ultrasonic medicinal introducing apparatus 31, and measuring system includes optical measurer 3, surpasses
Acoustic measurement instrument 7, charge coupled cell 10, temperature sensor 18, pressure sensor 19, oxygen atom detector 20, visual pursuit
Measuring instrument 25, microsensor 29.Vacuum plant 6, closed chamber 2.In one embodiment, ultraviolet laser and green light swash
The light path of light device shares a laser amplitude device.
The ultraviolet wavelength that ultraviolet laser 5 is sent out irradiates the energy density range on surface within the scope of 365 ± 10nm
For 0-100mW/cm2, irradiation surface diaphragm diameter is in 7-13mm, with irradiation surface distance 8-15mm.It possesses independent current source,
Inside possesses independent counter, and run time is automatically powered off more than 10min.
The wavelength for the green light that green (light) laser 30 is sent out irradiates the energy density range on surface within the scope of 532 ± 10nm
For 0-0.50W/cm2, the diaphragm diameter for irradiating surface is 8-15mm at a distance from 1-1.5cm, with irradiation surface.It possesses independence
Power supply.
In tunable optical component group, the first optical element 11, the second optical element 12 can be in light paths by driver 24
Control moves freely, and the first beam-splitter 14, the second beam-splitter 15, third beam-splitter 17 and reflecting plate 16 are controlled simultaneously by driver 24
And can planar rotate, laser amplitude device 13 can be moved in light path and can be revolved in the plane perpendicular to light path
Turn.
Preferably, one is placed in the horizontal optical path of the first optical element 11 and the second optical element 12 horizontal to move
Dynamic Darman raster element 23 is a kind of optical diffraction device, can predetermined region formed required dot pattern with
And various patterns of different shapes.
Central processing unit 1 can carry out all data transmissions, it can be achieved that closed-loop control with operating platform 4.
Operating platform 4 is gathered around there are one complete operation interface, can be preserved with real-time observed data and the book of final entry, in
Central processor 1 carries out mandatory control to each component, and possesses independent power supply.
Oxygen feedway is supplied oxygen by oxygen storage tank 9, and by oxygen atom detector 20 to the feedback of oxygen concentration, in
Central processor 1 can control the amount of oxygen and pressure in closed chamber 2 by controlling the opening and closing of solenoid valve.
The electro-ionic osmosis device 8 that solution instills in absorption plant includes electro-ionic osmosis electrode slice 27, and electro-ionic osmosis device 8 is gathered around
There are independent DC power supply, current control to be led using cricoid light-permeable in 0.5-2.5mA, the cathode of electro-ionic osmosis electrode slice 27
Electric material is attached to ocular surface or thickens 28 surface of film.
The film 28 that thickens that solution instills in absorption plant is a kind of good biofilm of biocompatibility, is attached to cornea
Surface avoids cornea by the excessive radiation in ultraviolet light.According to clinical different needs, the film of different-thickness, day are chosen
The preferred amnion of right film, the preferred electrostatic spinning biofilm of artificial bio-membrane's film of tailored thicknesses.Drug and light can be penetrated smoothly
Amnion or artificial bio-membrane's film reach required surface to be treated, and gas permeability, translucency are good, oxygen by it with it is extraneous into
Row exchanges.
The multiple sensors such as lambda sensor, sensitizer concentration sensor, pressure sensor can be installed thickening film inner surface,
The material requirements of these sensors is light-permeable, there is independent micro power and circuit.
Solution instills the photosensitizer injection device 21 of absorption plant, its drug use the principle that is atomized liquid ultrasonic into
Row spray, inside can install an electrically heated rod and temperature sensor additional, be convenient for photosensitizer absorption, temperature can be controlled
At 35 DEG C -40 DEG C.Selected photosensitizer can generate cross-linking reaction under the irradiation of ultraviolet light or green light with oxygen, be
One kind transportable solion under the action of voltage.The preferred riboflavin solution of photosensitizer of ultraviolet light, green light it is photosensitive
The preferred tiger of agent is red, can also mix both solution in proportion.
It can also include a kind of variation that solution, which instills device, be exactly to smear surface in drug, install an infrared heating additional
Device 26, infrared wave-length coverage (not damaged to ocular tissue), i.e., 1.5-3.0 μm in, spot diameter 5-15mm.
Solution instills the ultrasonic medicinal introducing apparatus 31 in device, its strength range is 0-1.5W/cm2, the frequency of ultrasonic wave
Rate is 10-30kHz.
Measuring system includes an optical measurer 3, measures the distance between anterior corneal surface and equipment and angle, and will count
According to being transported in central processing unit 1.
Measuring system may include an independent visual pursuit measuring instrument 25, it is the non-art eye 0 ' of observation, this equipment will
Related with treated eyes (art eye) 0 other equipment generates linkage, to control need to treat light path irradiating angle and away from
From.
Ultrasonic meter 7 sends out ultrasonic wave to irradiation surface, receives ultrasonic signal and is transmitted to central processing unit 1, with
Calculate the variation of the parameters such as anterior corneal surface regionality elasticity modulus.
Charge coupled cell 10 is converted into electric signal by processing to optical signal and is transmitted to central processing unit.
18 surface temperature of temperature sensor is detected and is transmitted to central processing unit 1.
Pressure sensor 19 is detected the pressure value in closed chamber 2 and is transmitted to central processing unit 1.
Microsensor 29 in measuring system is fitted in the inner surface that auxiliary thickens film, can be taken with many places a little, surface
The material of circlewise light-permeable can be designed, and microcircuit can be installed, centre is transferred data to by electromagnetic wave
Manage device 1.
Closed chamber 2, there are one ring is inhaled, negative pressure is formed when vacuum plant 6 works with eyes junction in chamber,
Firmly it is adsorbed on the skin of ocular surface.
The operation principle and the course of work of embodiment set forth further below.
As shown in Figure 1, the light come out through ultraviolet laser 5 is by the first optical element 11, the second optical element 12, it can be with
Using two parallel moveable lens groups, user sends out signal to central processing unit 1 by operating platform and automatically adjusts,
Can also be mechanical hand adjustment, principle is identical as the flexible principle of camera lens, it is therefore an objective to form energy density and diameter is big
Small suitable aperture.As shown in figure 5, including also a green (light) laser 30, it is arranged in parallel with ultraviolet laser 5 and light path, work
Green (light) laser 30 is first opened when making, and ultraviolet laser 5 is then turned on when the mechanics parameter of measurement does not change and continues to shine
It penetrates.The mixed solution that photosensitizer selects riboflavin red with tiger is configured.
As shown in Figure 1, by the first optical element 11, the second optical element 12 light via beam-splitter 14, part warp
It crosses beam-splitter 15 and reaches charge coupled cell 10, being converted into electric signal by processing is transmitted to central processing unit 1, passes through specific journey
Sequence calculates the intensity of illumination.
It is reflected into speculum 16, by beam-splitter 17 by a light part for beam-splitter 15, main optical path is eventually passed back to, with warp
The light for crossing the reflection of beam-splitter 14 converges.Beam-splitter 14, beam-splitter 15, beam-splitter 17, speculum 16 can rotate freely, wherein
Beam-splitter 17, speculum 16 can be moved in vertical direction, and all processes are controlled by central processing unit 1.The light of main optical path
Irradiation light 41 is converged into after being overlapped mutually with light through reflection, when the phase of two-way light differs the integral multiple of some fixed numbers,
Strip interference fringe 42 can be formed on irradiation surface.By adjusting beam-splitter 14, beam-splitter 15, beam-splitter 17, speculum 16
Movement and rotation, being formed by strip interference fringe can move in irradiation area.
As shown in Fig. 2, a Darman raster element 23 is placed in where the first optical element 11, the second optical element 12
Light path on, in this way irradiation surface just form laser dot-matrix pattern 43 as shown in FIG. 6, can also use other patterns light
Learn diffractive optical element, such as annular.This pattern forms periodic fluctuation on treatment surface.
As shown in Figure 1, laser amplitude device 13 can be mobile in vertical direction and be rotated, it can by adjusting laser amplitude device 13
With control irradiation surface energy, this process also by central processing unit 1 control, it is therefore an objective to allow irradiation surface energy density
Reach in the required range for the treatment of.
As shown in Figure 1, optical measurer 3 receives the light returned from irradiation surface reflection, pass through the signal of central processing unit
Processing calculates equipment to the distance of anterior corneal surface, can also calculate corneal thickness.Optical measurer 3 can install one additional solely
Vertical illumination unit, such as independent laser range finder can independently measure the thickness of cornea, without others at any time
Light source is supported.
As shown in figure 3, by visual pursuit measuring instrument 25, the capture of corneal center can be carried out to non-art eye surface, then
The position that beam-splitter 14, beam-splitter 15, beam-splitter 17 and speculum 16 are adjusted by central processing unit 1, allows laser irradiation to exist
Treatment region.What visual pursuit measuring instrument 25 was in alignment with is that non-art eye passes through fixation because the characteristics of motion of human eye is the same
Equipment place and calibrate for error, allow the movement that equipment follows non-art eye that can voluntarily adjust light path, allow light path according to wanting
Ask the surface for being radiated at art eye.
As shown in Figure 1, pressure sensor 19 and oxygen atom detector 20 by closed chamber 2 pressure value and oxygen atom it is dense
The numerical value of degree sends central processing unit 1 to, and central processing unit 1 adjusts oxygen by simulating the amount of oxygen control solenoid valve of needs
The oxygen output of gas storage tank 9.
As shown in Figure 1, vacuum plant 6 starts with to be responsible for, by the air discharge in closed chamber 2, being formed negative in equipment
Pressure, such closed chamber 2 can be fixed on by inhaling ring on the skin around eyes, after oxygen 45 is passed through, ensure internal oxygen
Gas concentration can improve.Vacuum plant 6 ensures that initial pressure is negative value in closed chamber, when hypertonia in closed chamber 2 or
Person reduces the concentration of medium of heat transfer, can according to circumstances work at any time.Closed chamber 2 can also install one additional visually in side
The case where transparent window, doctor can observe the inside by the window.Complete equipment can pass through elastic band or similar cap
The device of shape is fixed on the head of people.
By adjusting pressure in closed chamber 2, elastic deformation can occur for cornea.Ultrasonic meter 7 is sent out to irradiation surface
Go out ultrasonic wave and received, the ultrasonic signal 44 of reception can also change, by receiving ultrasonic signal and being transmitted to
Central processor 1 calculates the variation of the parameters such as anterior corneal surface regionality elasticity modulus, and cornea table can also be simulated by software
The case where face, can observe the mechanical property comparison of different location on the cornea contours figure of simulation in operating platform 4.
As shown in figure 11, it is that the patient according to particular patients ' such as corneal thickness less than 400 μm wears to thicken film 28, is selected
Natural biological film or the relatively good artificial bio-membrane's film of biocompatibility, natural biological film such as amnion, tailored thicknesses it is artificial
The preferred electrostatic spinning biofilm of biofilm.Microsensor 29, this sensing can be placed in the inner surface for thickening film 28
Device has good translucency, can place minicell, and the pressure of the ocular surface of measurement is transmitted to central processing unit 1.?
Different sensor measurement other parameters, such as the photosensitizer concentration on surface, oxygen concentration etc. can be installed.
Atomizer is installed on photosensitizer injection device 21 as shown in Figure 1, is injected in the center of cornea,
Internal there are one the heating rods or resistance wire that can be heated to photosensitizer, are heated to it before photosensitizer needs to inject.Lead to again
It crosses ultrasonic medicinal introducing apparatus 31 and ul-trasonic irradiation is carried out to photosensitizer, increase absorption of the eyes to photosensitizer.As Fig. 4 can
The irradiation surface of cornea adds an infrared heater 26, this illuminator is directed at cornea and is irradiated over the course for the treatment of,
The temperature field gone into anterior corneal surface, 18 surface temperature of temperature sensor are fed back.
As shown in Fig. 1 and Fig. 9, an electro-ionic osmosis device 8 with independent DC power supply is installed additional in anterior corneal surface, it can be with
Design reticulates or spiral helicine electro-ionic osmosis electrode slice is attached to eyeball surface, and material has the property of light transmission.It can be with
Electro-ionic osmosis device 8 is installed to the inner surface for thickening film, it is integrated with microsensor.
Illumination and the drug for the treatment of can be adjusted according to measurement parameter using suitable software based on this set therapeutic equipment
Supply amount personalized therapeutic scheme is simulated according to the analysis of big data, accurate treatment is implemented to affected part.This is one
The control system of closed loop, measurement parameter include corneal tension, temperature, oxygen concentration etc., and the parameter of input includes age, gender, disease
History, corneal thickness, corneal topography etc..Related data and the process for the treatment of can be stored in electronic databank, form one completely
Electronic record is convenient for postoperative tracking.And analyze the process for the treatment of comprehensively according to big data, it is formed and constantly tends to be rationally perfect
Information bank is treated, the treatment for follow-up other patients is provided based on clinical comparison information.
As shown in the flow in Figure 12, the basic parameter of acquisition includes the age of patient, gender, medical history, corneal thickness, angle
The essential informations such as film topographic map.Data control group includes data of some basic parameters with reference to value, computer can according to
Past therapeutic process, therapeutic effect to treatment carry out analysis mode, the parameter measured in real time include the temperature of cornea, cornea bullet
The data such as property modulus, concentration of oxygen atoms.These real-time measured parameters can be compareed according to the safety value that a database generates,
If without in zone of reasonableness, equipment can stop, and doctor can according to circumstances be adjusted.Such as in the reasonable scope, these parameters
It can be carried out with the computer simulation desired amount generated to illumination group for being treated to cornea, the treatment intermittent phase will continue to survey
Amount, reaches effect, and treatment can stop, if not up to effect can also return to be compareed with safety value, repeatedly, until
Treatment stops.
The information that patient treats in archives can upload to other servers being connected with network, and server is by directly obtaining
It obtains relevant data and carries out analyzing processing, improve existing database, more accurate guidance is provided to therapeutic process.This is a set of
Method for updating system based on big data can gradual systematization, the treatment of other ophthalmology diseases can also be served data to.
The above content is specific/preferred embodiment further description made for the present invention is combined, cannot recognize
The specific implementation of the fixed present invention is confined to these explanations.For those of ordinary skill in the art to which the present invention belongs,
Without departing from the inventive concept of the premise, some replacements or modification can also be made to the embodiment that these have been described,
And these are substituted or variant all shall be regarded as belonging to protection scope of the present invention.
Claims (20)
1. a kind of device for treating cornea tissue disease, which is characterized in that including：
Central processing unit；
Laser group, including ultraviolet laser and green (light) laser, the two are arranged light-source system in pairs parallel, when work described in
Central processing unit, which first controls, opens the green (light) laser, is controlled again described in unlatching when the mechanics parameter of measurement does not change
Ultraviolet laser continues to irradiate；
Tunable optical component group, for the light source of laser group being sent to art eye surface according to the light pattern of setting and can be by described
Central processing unit controls, and the irradiation of laser is adjusted, so as to reach the desired effect of cross-linking reaction on irradiation surface；
Closed chamber is internally provided with for adsorbing ocular tissue's surrounding skin to fix the suction ring of art eye；
Oxygen feedway is supplied oxygen for conveying oxygen into the closed chamber for cross-linking reaction；
Solution instills absorption plant, and for importing the drug containing photosensitizer to art eye surface, photosensitizer is using riboflavin and tiger
The red component mixed in proportion, to generate cross-linking reaction in oxygen under ultraviolet light and green light irradiation；
Observed result for being observed in real time cornea therapy situation, and is transmitted to the central processing unit by measuring system
It is handled.
2. the device as described in claim 1 for treating cornea tissue disease, which is characterized in that further include vacuum plant,
For carrying out forvacuum processing to the closed chamber, make the indoor skin inhaled around ring absorption ocular tissue of the closing chamber
Skin, while also promoting the indoor air discharge of the closing chamber to improve the ratio shared by the indoor oxygen of the closing chamber.
3. the device as described in claim 1 for treating cornea tissue disease, which is characterized in that the green (light) laser hair
The wavelength of the green light gone out irradiates the energy density ranging from 0-0.50W/cm on surface within the scope of 532 ± 10nm2, irradiate surface
Diaphragm diameter in 1-1.5cm, be 8-15mm at a distance from irradiation surface；The ultraviolet wavelength that the ultraviolet laser is sent out
Within the scope of 365 ± 10nm, the energy density ranging from 0-100mW/cm on surface is irradiated2, irradiation surface diaphragm diameter is in 7-
13mm, with irradiation surface distance 8-15mm.
4. the device as claimed in claim 3 for treating cornea tissue disease, which is characterized in that the ultraviolet laser
Run time reaches the predetermined time and automatically powers off.
5. the device as claimed in claim 4 for treating cornea tissue disease, which is characterized in that the ultraviolet laser
Run time automatically powers off when reaching 10min.
6. the device as described in claim 1 for treating cornea tissue disease, which is characterized in that the tunable optical component
Correspond to ultraviolet laser in group and green (light) laser respectively include can be by the first optical element that driver is adjusted, the second light
Learn element, laser amplitude device, the first beam-splitter, the second beam-splitter, reflecting plate, third beam-splitter, first optical element, institute
Stating the second optical element, the reflecting plate, the third beam-splitter, the laser amplitude device can be in light path by driver control
Translation and rotation；The light that the ultraviolet laser comes out is by first optical element, second optical element, so as to shape
At the aperture that energy density and diameter are suitable；By first optical element, the light one of second optical element
Divide and reflected by first beam-splitter, another part is partly reflected by second beam-splitter after first beam-splitter
To the speculum, is reflected by the third beam-splitter through speculum reflection, be finally divided with by described first again
The light of plate reflection meets at main optical path, and two-way light is overlapped mutually, when the phase of two-way light differs the integral multiple of some fixed numbers
When on irradiation surface form strip interference fringe, pass through and adjust first beam-splitter, second beam-splitter, the reflection
The movement and rotation of plate, the third beam-splitter, being formed by strip interference fringe can move in irradiation area；The laser
Modulator makes the energy density on irradiation surface in the required range for the treatment of for regulating and controlling the energy on irradiation surface.
7. the device as claimed in claim 6 for treating cornea tissue disease, which is characterized in that the tunable optical component
Group further includes the Darman raster element in the light path where being placed in first optical element and second optical element, with
Laser dot-matrix pattern is formed on irradiation surface, or using the optical diffraction device for generating circular pattern on irradiation surface.
8. the device for treating cornea tissue disease as described in claim 1, which is characterized in that the measuring system includes
Pressure sensor and oxygen atom detector, the pressure sensor and the oxygen atom detector are used for will be in the closed chamber
Pressure value and the numerical value of concentration of oxygen atoms send central processing unit to, the central processing unit is adjusted by controlling solenoid valve
The oxygen output of the oxygen feedway.
9. the device as described in claim 1 for treating cornea tissue disease, which is characterized in that the solution, which instills, to be absorbed
Device includes electro-ionic osmosis device, photosensitizer injection device, infrared heater and ultrasonic medicinal introducing apparatus；The electro-ionic osmosis
Device includes the netted or spiral helicine electro-ionic osmosis electrode slice for being attached to eyeball surface；The photosensitizer injection device includes
By the atomizer on liquid ultrasonic atomized spray to cornea；The ultrasonic medicinal introducing apparatus applies ul-trasonic irradiation to photosensitizer
To increase absorption of the eyes to photosensitizer；The infrared heater irradiates cornea over the course for the treatment of, to form anterior corneal surface
Temperature field.
10. the device as claimed in claim 9 for treating cornea tissue disease, which is characterized in that the photosensitizer injection
The heating rod or resistance wire for heating photosensitizer are set in device.
11. the device as claimed in claim 10 for treating cornea tissue disease, which is characterized in that the photosensitizer injection
Heating rod or resistance wire in device control temperature at 35 DEG C -40 DEG C.
12. the device as described in any one of claim 1 to 11 for treating cornea tissue disease, which is characterized in that described
Measuring system includes optical measurer, ultrasonic meter, charge coupled cell, temperature sensor；The optical measurer inspection
The light returned from irradiation surface reflection is surveyed, so that central processing unit calculates device to anterior corneal surface according to detection optical signal prosessing
Distance and angle and corneal thickness；The ultrasonic meter sends out ultrasonic wave to irradiation surface, receives the ultrasound of return
Signal is simultaneously transmitted to the central processing unit, to calculate the variation of the parameters such as anterior corneal surface regionality elasticity modulus；The electricity
Optical signal and processing in lotus coupling element light path are converted into electric signal and are transmitted to the central processing unit, to calculate light extraction
According to intensity；The temperature sensor detects anterior corneal surface temperature and is transmitted to central processing unit.
13. the device as claimed in claim 12 for treating cornea tissue disease, which is characterized in that the optical measurer
Equipped with independent illumination unit independently to measure the thickness of cornea.
14. the device as described in any one of claim 1 to 11 for treating cornea tissue disease, which is characterized in that described
Measuring system includes visual pursuit measuring instrument, and the visual pursuit measuring instrument observes non-art eye, and cornea is carried out to non-art eye surface
The capture at center, the central processing unit adjust the tunable optical component according to the observed case of the visual pursuit measuring instrument
Group is to control irradiating angle and distance of the treatment light path for art eye.
15. the device as described in any one of claim 1 to 11 for treating cornea tissue disease, which is characterized in that also wrap
The film that thickens with biocompatibility for being attached to anterior corneal surface is included, drug, light, oxygen can penetrate the film that thicken and reach institute
Surface in need for the treatment of.
16. the device as claimed in claim 15 for treating cornea tissue disease, which is characterized in that the film that thickens is day
Right film or artificial bio-membrane's film.
17. the device as claimed in claim 16 for treating cornea tissue disease, which is characterized in that the natural membranes is sheep
Film.
18. the device as claimed in claim 16 for treating cornea tissue disease, which is characterized in that the artificial bio-membrane is thin
Film is electrostatic spinning biofilm.
19. the device as claimed in claim 15 for treating cornea tissue disease, which is characterized in that described to thicken the interior of film
Surface mount has the microsensor of light transmission, includes the pressure of ocular surface, photosensitizer concentration, oxygen concentration, cornea for measuring
One or more parameters in mechanical property, and it is transmitted to central processing unit.
20. the device as claimed in claim 19 for treating cornea tissue disease, which is characterized in that described to thicken the interior of film
Surface is also equipped with micro radio circuit, and central processing unit is transferred data to by wireless transmission.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810988183.0A CN109199689B (en) | 2016-10-13 | 2016-10-13 | Cornea treatment device based on adjustable optical element group and solution dripping absorption device |
| CN201810990301.1A CN109248022B (en) | 2016-10-13 | 2016-10-13 | Corneal treatment device based on improved adjustable optical element set |
| CN201810988212.3A CN108992243B (en) | 2016-10-13 | 2016-10-13 | Cornea treatment device based on improved solution dripping absorption device |
| CN201610895446.4A CN106264855B (en) | 2016-10-13 | 2016-10-13 | A kind of device for treating cornea tissue disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610895446.4A CN106264855B (en) | 2016-10-13 | 2016-10-13 | A kind of device for treating cornea tissue disease |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810988212.3A Division CN108992243B (en) | 2016-10-13 | 2016-10-13 | Cornea treatment device based on improved solution dripping absorption device |
| CN201810990301.1A Division CN109248022B (en) | 2016-10-13 | 2016-10-13 | Corneal treatment device based on improved adjustable optical element set |
| CN201810988183.0A Division CN109199689B (en) | 2016-10-13 | 2016-10-13 | Cornea treatment device based on adjustable optical element group and solution dripping absorption device |
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| Publication Number | Publication Date |
|---|---|
| CN106264855A CN106264855A (en) | 2017-01-04 |
| CN106264855B true CN106264855B (en) | 2018-11-06 |
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| CN201610895446.4A Active CN106264855B (en) | 2016-10-13 | 2016-10-13 | A kind of device for treating cornea tissue disease |
| CN201810988212.3A Active CN108992243B (en) | 2016-10-13 | 2016-10-13 | Cornea treatment device based on improved solution dripping absorption device |
| CN201810990301.1A Active CN109248022B (en) | 2016-10-13 | 2016-10-13 | Corneal treatment device based on improved adjustable optical element set |
| CN201810988183.0A Active CN109199689B (en) | 2016-10-13 | 2016-10-13 | Cornea treatment device based on adjustable optical element group and solution dripping absorption device |
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| CN201810988212.3A Active CN108992243B (en) | 2016-10-13 | 2016-10-13 | Cornea treatment device based on improved solution dripping absorption device |
| CN201810990301.1A Active CN109248022B (en) | 2016-10-13 | 2016-10-13 | Corneal treatment device based on improved adjustable optical element set |
| CN201810988183.0A Active CN109199689B (en) | 2016-10-13 | 2016-10-13 | Cornea treatment device based on adjustable optical element group and solution dripping absorption device |
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Also Published As
| Publication number | Publication date |
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| CN108992243A (en) | 2018-12-14 |
| CN109199689A (en) | 2019-01-15 |
| CN106264855A (en) | 2017-01-04 |
| CN108992243B (en) | 2020-05-22 |
| CN109199689B (en) | 2020-05-22 |
| CN109248022A (en) | 2019-01-22 |
| CN109248022B (en) | 2020-06-02 |
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