CN106236922A - A kind of Chinese medicine composition treating tinea pedis or tinea pedis and preparation method thereof - Google Patents
A kind of Chinese medicine composition treating tinea pedis or tinea pedis and preparation method thereof Download PDFInfo
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- CN106236922A CN106236922A CN201610761663.4A CN201610761663A CN106236922A CN 106236922 A CN106236922 A CN 106236922A CN 201610761663 A CN201610761663 A CN 201610761663A CN 106236922 A CN106236922 A CN 106236922A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K36/13—Coniferophyta (gymnosperms)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The present invention relates to a kind of external medicine composition and preparation method thereof, particularly relate to a kind of Chinese medicine composition treating tinea pedis and preparation method thereof.The raw material preparing its active component includes Nicotiana tabacum L., Cortex Pseudolaricis, Fructus Cnidii, Radix Et Rhizoma Rhei etc..The preparation method of the Chinese medicine composition of described treatment tinea pedis includes: 1) extracted by solubilizer after the dry sterilizations such as Nicotiana tabacum L., Cortex Pseudolaricis, Fructus Cnidii, Radix Et Rhizoma Rhei；Add Borneolum Syntheticum to extract and obtain compositions finished product.The product prepared by the inventive method has horny layer softening, the effect of protection skin, makes pathomycete to go out, and tinea pedis must heal.
Description
Technical field
The present invention relates to a kind of external medicine composition and preparation method thereof, particularly relate to a kind of Chinese drug-treated group treating tinea pedis
Compound and preparation method thereof.
Background technology
Tinea pedis is the popular name of tinea pedis.Somebody lumps " tinea pedis " and " vitamin B1 deficiency " together, this be not to.Medically
" vitamin B1 deficiency " is because the systemic disease that Vitamin B deficiency causes, and " tinea pedis " is then that the one caused by fungal infection is normal
The dermatosis seen.Due to suffer from tinea pedis, tinea pedis people a lot, bundle disturbs the live and work of people always, brings non-to patient
The biggest inconvenience.At present, the medicine for the treatment of tinea pedis also has much, although have some curative effects to patients with mild, but effect is all paid no attention to
Think, moreover can not thoroughly cure, easily recur, there is a lot of shortcoming.Sell in the market and the most widely used control
Treating the external used medicine of tinea pedis, major part is the constituent of Chinese medicine, and bactericidal effect is poor, it is difficult to radical cure tinea pedis；Another part is by west
Medicine forms, and such as daktarin, Lan Meishu etc., these medicine for external use are all made up of different western medicine compositions, and component, proportioning are respectively arranged with not
With.They exist following not enough: 1, Quick itch stopping DeGrain；2, there is negative interaction in varying degrees, as life-time service can draw
Playing skin allergy, there is little red pimple in local；3, relapse rate is higher, it is impossible to eradicate tinea pedis etc..Tinea pedis patient just locates for a long time
In such a treatment, alleviate, drug withdrawal, recurrence, among the vicious cycle treated again.And the reason of tinea pedis morbidity is mainly by cause of disease
Bacterium is contaminated and causes, and other skin erosion, blister, keratinization, the phenomenons such as pain of feeling to itch are all the subsidiary diseases after Pathogen Infection
Shape.Therefore, it is possible to rapidly and efficiently kill pathogenic microorganism to be only the key factor having treated tinea pedis.
Summary of the invention
The problem to be solved in the present invention is aiming at above deficiency and provides one can rapidly and efficiently kill the micro-life of cause of disease
Thing, thoroughly eradicates the medicine of tinea pedis, tinea pedis.Its technical scheme is as follows:
A kind of Chinese medicine composition treating tinea pedis, its key technology is that the raw material preparing its active component includes following heavy
The raw material of amount part:
Nicotiana tabacum L. 10-30 part, Cortex Pseudolaricis 5-20 part, Fructus Cnidii 3-12 part, Radix Sophorae Flavescentis 3-12 part, Radix Et Rhizoma Rhei 2-9 part, Borneolum Syntheticum 2-6 part.
The raw material preferably preparing its active component includes the raw material of following weight portion:
20 parts of Nicotiana tabacum L., Cortex Pseudolaricis 10 parts, Fructus Cnidii 6 parts, Radix Sophorae Flavescentis 6 parts, Radix Et Rhizoma Rhei 4 parts, Borneolum Syntheticum 4 parts.
The preparation method of the Chinese medicine composition of described treatment tinea pedis, comprises the following steps:
1) Nicotiana tabacum L. 10-30 part, Cortex Pseudolaricis 5-20 part, Fructus Cnidii 3-12 part, Radix Sophorae Flavescentis 3-12 part, Radix Et Rhizoma Rhei 2-9 part are existed respectively
Pulverize after dry sterilization at a temperature of 60-80 DEG C, sieve stand-by；
2) Nicotiana tabacum L., Cortex Pseudolaricis, Fructus Cnidii, Radix Sophorae Flavescentis and Rhubarb are inserted in percolation filtration extraction pot, add 100-120 part white
The mixed liquid dipping of vinegar and 300-320 part 75% ethanol 48 hours；
3) with 3ml/ minute slowly percolation；
4) collect percolate 200 parts, add Borneolum Syntheticum 2-6 part and ethyl hydroxybenzoate obtains compositions finished product；
Spray is made in the compositions finished product fill that can above-mentioned steps be made in spray bottle, and every bottle of compositions becomes
Product 50ml.
The active component of medicine of the present invention can also add various customary adjuvant required when preparing different dosage form, such as anticorrosion
Agent, paste substrate etc. are prepared as any conventional exterior-applied formulation with conventional method of Chinese medicinal, such as liniment, ointment, coagulate
Colloid etc..
Compared with prior art, the invention have the advantages that:
1, the traditional Chinese medical science thinks that vitamin B1 deficiency mostly is damp and hot invasion and attack, and damp invasion of lower energizer is done；Modern medicine thinks mainly fungal infection
Cause, in conjunction with Chinese and western medicine theory, control and work as with heat clearing away by wet, for the purpose of killing parasites for relieving itching.The present invention goes out from the cause of disease of tinea pedis, pathology
Send out, select following plant and Chinese herbal medicine compatibility to reach to treat the purpose of tinea pedis: Nicotiana tabacum L. contains substantial amounts of alkaloid component, always gives birth to
Alkaloids content in the range of 1%～9%, Nicotiana tabacum L. possibly together with putrescine class (coffee amide, p-coumaric acyl putrescine etc.), Salanesol,
Multiple organic acid isoreactivity composition, anti-mycotic efficiency is notable, has effect of detumescence, removing toxic substances, parasite killing；Cortex Pseudolaricis has certain
Parasite killing, treating tinea, antipruritic effect, its chemical composition contains substantial amounts of organic acid (pseudolaric acid B) to be had fungus and stronger kills work
With；Fructus Cnidii has dampness, dispels the wind, effect of parasite killing, containing compositions such as Coumarins composition osthole, volatile oil, has relatively
Strong antifungic action；Radix Sophorae Flavescentis has heat clearing and damp drying, effect of parasite killing, and its alkaloid component matrine and oxymatrine have
Stronger antifungic action；Purge heat poison, clearing away heat and cooling blood, removing toxic substances of Radix Et Rhizoma Rhei, by silt, mainly contains the compositions such as substantial amounts of anthraquinone derivative,
Pharmacology shows there is antifungic action；Borneolum Syntheticum has effect of consciousness-restoring and orifice-opening, clearing away heat to alleviate pain, erosion prevention and muscle growing, and modern pharmacology shows tool
There is certain antifungic action, there is in preparation certain transdermal effect, can be used for profound fungus and kill.
2, using the combination of Nicotiana tabacum L. and Chinese medicine, the efficacy of a drug strengthening prescription is had beyond thought effect, all medicines share,
From the endogenous cause of ill cured the disease, removing dampness is dispeled the wind, sterilizing and itch-relieving, controls it at all, emphatically conditioning.Clinical test results shows: to treatment
Being had specially good effect by fungus-caused tinea pedis (tinea pedis), the cure rate of patients with mild is 100%, and the cure rate of moderate patient is 99%,
The cure rate of severe patient is 96%, invalid substantially zeroed, solves pure Chinese medicinal preparation poor effect in prior art, chemical drugs
The problem that product toxic and side effects is big.For suffering from the moist dermatosis of foot, interdigit is rotten to the corn, and pain of itching acutely, unbearably, walk by pruritus
For the patient of difficulty, especially suitable.
3, solvent for use acetic acid of the present invention and ethanol also have beyond thought therapeutical effect: acetic acid has to be killed very in a large number
Effect of bacterium, fungus mainly survives in alkaline environment, sterilizes for acidity by changing the PH of preparation, and acetic acid extraction is raw simultaneously
Alkaloids composition has certain hydrotropy effect；The ethanol of 75% has certain sterilization effect as solvent itself, and this is dense
The ethanol of degree can good effective component extracting.The product prepared with this solvent has horny layer softening, the effect of protection skin, makes
Pathomycete must be gone out, and tinea pedis must heal.
Drug regimen formula In Vitro Anti fungus contrast test, result is as follows:
1 test sample
Sample solvent white vinegar 100-120 part with 75% the mixed solution of ethanol 300-320 part；
Formula A: with preparation 0.125g/ml, 0.25g/ml, 0.50g/ml of independent Nicotiana tabacum L.；
The combination preparation of formula B: Nicotiana tabacum L. and Chinese medicine ingredients (Nicotiana tabacum L. 10-30 part, Cortex Pseudolaricis 5-20 part, Fructus Cnidii 3-12 part,
Radix Sophorae Flavescentis 3-12 part, Radix Et Rhizoma Rhei 2-9 part, Borneolum Syntheticum 2-6 part) 0.125g/ml, 0.25g/ml, 0.50g/ml；
Combination preparation (Cortex Pseudolaricis 5-20 part, Fructus Cnidii 3-12 part, Radix Sophorae Flavescentis 3-12 part, the Radix Et Rhizoma Rhei 2-9 of formula C: pure Chinese medicine
Part, Borneolum Syntheticum 2-6 part) 0.125g/ml, 0.25g/ml, 0.50g/ml；
2 for examination strain
Superficial mycosis: trichophyton (T1a)；Alpha fungus (T2a)；Acrothesium floccosum (E1c)；Deep fungal:
Candida albicans (C1c)；Cryptococcus histolyticus (D2a).
3 test methods and result
The method using In Vitro Anti mycologic test measures the bacteriostasis and sterilization effect of each formula concentration, measurement result such as table:
Conclusion: by In Vitro Anti mycologic test, uses the combination with Chinese medicine of the Nicotiana tabacum L. single folk prescription than single Nicotiana tabacum L. folk prescription
And the In Vitro Anti antifungal effect of Chinese medicine formula is more preferable, its medicinal liquid valid density 0.25g/ml just can reach to kill the purpose of fungus.
Drug regimen formula clinical comparison is tested, and result is as follows:
Experimental group: experimental subject: tinea pedis patient populations is 200, wherein patients with mild number is 50, moderate patient people
Number is 100, and severe patient numbers is 50.
Experimental technique: as a example by the combination of the treatment tinea pedis of formula offer, be used for treating tinea pedis.The consumption of medicine is every day
Twice, totally three weeks.
Matched group: experimental subject: tinea pedis patient populations is 200, wherein patients with mild number is 50, moderate patient people
Number is 100, and severe patient numbers is 50.
Experimental technique: the medicine of the treatment tinea pedis to sell on market, is used for treating tinea pedis.The consumption of medicine is every day two
Secondary, totally three weeks.
Test group is identical with M-F in the tinea pedis patient that matched group is selected, and age bracket is similar.
Efficacy assessment standard:
Recovery from illness: tinea pedis symptom is wholly absent, and does not continues to medication.
Effective: tinea pedis symptom has clear improvement, and needs continual cure.
Invalid: tinea pedis symptom, without improving, need to be treated with other medicines.
The experimental data of clinical trial
Conclusion: from data in table, uses the combination of Nicotiana tabacum L. and Chinese medicine, has a specially good effect to the treatment of tinea pedis, invalid substantially
It is zero.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is further described, and detailed description of the invention is to enter the principle of the invention
One step explanation, limits the present invention never in any form, and technology same or like with the present invention is protected without departing from the present invention
Scope.
Embodiment 1
1) medicinal material drying is pulverized: taking 20 parts of Nicotiana tabacum L., Cortex Pseudolaricis 10 parts, Fructus Cnidii 6 parts, Radix Sophorae Flavescentis 6 parts, Radix Et Rhizoma Rhei 4 parts, medical material is adopted
It is dried sterilizing, baking temperature 60-80 DEG C by dry sterilization mode, dried material is put in pulverizer and pulverize, cross 10
Mesh sieve is standby；
2) extract: by above-mentioned Nicotiana tabacum L., Cortex Pseudolaricis, Fructus Cnidii, Radix Sophorae Flavescentis and Rhubarb 100 parts of white vinegars and the ethanol of 75%
300 parts of mixed liquid dippings 48 hours；
3) percolation: percolation speed controlling, at 3ml/ minute, collects liquid 200 parts；
4) proportioning process: Borneolum Syntheticum 4 parts and preservative ethyl hydroxybenzoate (0.05%) are dissolved in percolation liquid by formula proportion
In, stir；
5) fill: every bottled 50ml.
6) inspection: test according to company standard.
Embodiment 2
Step each with embodiment 1 is identical, is not both each one-tenth and is grouped into and presses row parts by weight: 10 parts of Nicotiana tabacum L., Cortex Pseudolaricis 5
Part, Fructus Cnidii 3 parts, Radix Sophorae Flavescentis 3 parts, Radix Et Rhizoma Rhei 2 parts, Borneolum Syntheticum 2 parts, white vinegar 110 parts, the ethanol 310 parts of 75%.
Embodiment 3
Step each with embodiment 1 is identical, is not both each one-tenth and is grouped into and presses row parts by weight: 30 parts of Nicotiana tabacum L., Cortex Pseudolaricis 20
Part, Fructus Cnidii 12 parts, Radix Sophorae Flavescentis 12 parts, Radix Et Rhizoma Rhei 9 parts, Borneolum Syntheticum 6 parts, white vinegar 120 parts, the ethanol 320 parts of 75%.
Claims (3)
1. the Chinese medicine composition treating tinea pedis or tinea pedis, it is characterised in that the raw material preparing its active component includes following heavy
The raw material of amount part:
Nicotiana tabacum L. 10-30 part, Cortex Pseudolaricis 5-20 part, Fructus Cnidii 3-12 part, Radix Sophorae Flavescentis 3-12 part, Radix Et Rhizoma Rhei 2-9 part, Borneolum Syntheticum 2-6 part.
Treatment tinea pedis or the Chinese medicine composition of tinea pedis the most according to claim 1, it is characterised in that prepare its active component
Raw material includes the raw material of following weight portion:
20 parts of Nicotiana tabacum L., Cortex Pseudolaricis 10 parts, Fructus Cnidii 6 parts, Radix Sophorae Flavescentis 6 parts, Radix Et Rhizoma Rhei 4 parts, Borneolum Syntheticum 4 parts.
3. treat the preparation method of the Chinese medicine composition of tinea pedis or tinea pedis described in claim 1, it is characterised in that include following step
Rapid:
1) by Nicotiana tabacum L. 10-30 part, Cortex Pseudolaricis 5-20 part, Fructus Cnidii 3-12 part, Radix Sophorae Flavescentis 3-12 part, Radix Et Rhizoma Rhei 2-9 part respectively at 60-80
Pulverize after dry sterilization at a temperature of DEG C, sieve stand-by；
2) Nicotiana tabacum L., Cortex Pseudolaricis, Fructus Cnidii, Radix Sophorae Flavescentis and Rhubarb are inserted in percolation filtration extraction pot, add 100-120 part white vinegar and
The mixed liquid dipping of 300-320 part 75% ethanol 48 hours；
3) with 3ml/ minute slowly percolation；
4) collect percolate 200 parts, add Borneolum Syntheticum 2-6 part and ethyl hydroxybenzoate obtains compositions finished product；
5) compositions finished product is made spray, liniment, ointment or gel.
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| CN101366859A (en) * | 2007-08-19 | 2009-02-18 | 余国强 | Medicament for treating tinea manus and pedis, fester foot |
| CN101987151A (en) * | 2009-08-04 | 2011-03-23 | 梁慧珠 | Traditional Chinese medicinal ointment for treating psoriasis |
| CN102247564A (en) * | 2010-11-29 | 2011-11-23 | 吴克 | Liquid preparation for treating dermatitis, eczema and the like and preparation method thereof |
| CN103751491A (en) * | 2011-10-13 | 2014-04-30 | 何克诚 | Medicament for treating dermatophytosis, psoriasis, dermatitis and flat wart, and treating method |
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| CN105395668A (en) * | 2015-12-29 | 2016-03-16 | 孟潇奇 | Traditional Chinese medicine composition for treating skin disease and preparation method thereof |
| CN105395670A (en) * | 2015-12-28 | 2016-03-16 | 天津钧濡科技有限公司 | Liquid medicine for treating dermatophytosis |
| CN105561203A (en) * | 2016-02-17 | 2016-05-11 | 蒋玉群 | Drug for treating comprehensive beriberi |
| CN105617268A (en) * | 2016-02-17 | 2016-06-01 | 蒋玉群 | Medicine for treating scale keratinization type beriberi |
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2016
- 2016-08-30 CN CN201610761663.4A patent/CN106236922A/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1136448A (en) * | 1995-05-24 | 1996-11-27 | 杨正祥 | Plant medicinal liquid for curing dermatosis |
| CN101366859A (en) * | 2007-08-19 | 2009-02-18 | 余国强 | Medicament for treating tinea manus and pedis, fester foot |
| CN101987151A (en) * | 2009-08-04 | 2011-03-23 | 梁慧珠 | Traditional Chinese medicinal ointment for treating psoriasis |
| CN102247564A (en) * | 2010-11-29 | 2011-11-23 | 吴克 | Liquid preparation for treating dermatitis, eczema and the like and preparation method thereof |
| CN103751491A (en) * | 2011-10-13 | 2014-04-30 | 何克诚 | Medicament for treating dermatophytosis, psoriasis, dermatitis and flat wart, and treating method |
| CN104352834A (en) * | 2014-10-13 | 2015-02-18 | 陈付峰 | Traditional Chinese medicine composition for treating dermatophytosis |
| CN104666594A (en) * | 2015-02-02 | 2015-06-03 | 田元生 | Moxibustion stick for treating tinea pedis and preparation method thereof |
| CN105395670A (en) * | 2015-12-28 | 2016-03-16 | 天津钧濡科技有限公司 | Liquid medicine for treating dermatophytosis |
| CN105395668A (en) * | 2015-12-29 | 2016-03-16 | 孟潇奇 | Traditional Chinese medicine composition for treating skin disease and preparation method thereof |
| CN105561203A (en) * | 2016-02-17 | 2016-05-11 | 蒋玉群 | Drug for treating comprehensive beriberi |
| CN105617268A (en) * | 2016-02-17 | 2016-06-01 | 蒋玉群 | Medicine for treating scale keratinization type beriberi |
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Application publication date: 20161221 |