CN106174463A - A kind of ultra micro nutrition prescription and preparation processing method preventing and treating hypertensive heart disease based on collaborative absorption - Google Patents
A kind of ultra micro nutrition prescription and preparation processing method preventing and treating hypertensive heart disease based on collaborative absorption Download PDFInfo
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Abstract
The invention discloses a kind of ultra micro nutrition prescription preventing and treating hypertensive heart disease based on collaborative absorption of the present invention, be made up of the raw material of following weight portion: Herba Patriniae 15 parts, Caulis Sargentodoxae 15 parts, Semen Coicis 15 parts, 10 parts of Semen Persicae, Retinervus Luffae Fructus 5 parts, 10 parts of wide Radix Rubiae, Radix Arnebiae (Radix Lithospermi) 10 parts, Fructus Crataegi 14 parts, Stigma Croci 1 part, Fructus Momordicae charantiae powder 7 parts, Herba Apii graveolentis 30 parts, Periostracum Cicadae 7.5 parts, Rhizoma Alismatis 3 parts, Rhizoma Coptidis 7.5 parts, Radix Angelicae Sinensis 7 parts, Flos Chrysanthemi 5 parts, Radix Angelicae Pubescentis 8 parts, Radix Cirsii Japonici 9 parts, 10 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, Mel, water are appropriate.The invention have the advantage that inventive formulation clots absorbing leads to stagnant, the row water that purifies the blood, treatment hypertensive heart disease, supplement the nutrients, assist treatment, improve self and increase the wriggling of the intestines and stomach, advantage, the merit of resisting fatigue such as enhancing body immunity simultaneously of curing the disease.
Description
Technical field
The present invention relates to a kind of ultra micro nutrition prescription preventing and treating hypertensive heart disease based on collaborative absorption, in particular,
Relate to a kind of based on the collaborative absorption ultra micro nutrition prescription preventing and treating hypertensive heart disease and preparation method thereof technical field.
Background technology
Hypertensive heart disease is referred to as hypertension by the best change causing cardiac function and structure of hypertension long-term control
Property heart disease, including: in early days Diastole Function go down, left ventricular hypertrophy (LVH), progressively development occur that myocardium shrinkage function goes down
Finally there is heart failure, have the heart failure of research display 70% by caused by hypertension；It is likely to occur associated hat simultaneously
Cardiopathia, the heart complication such as atrial fibrillation.The traditional Chinese medical science is thought and can be led to stagnant, the row water that purifies the blood, treatment hypertensive heart disease by clots absorbing.In
Doctor thinks leads to stagnant, the row water that purifies the blood, treatment hypertensive heart disease by clots absorbing.
For threpsology's angle, hypertensive heart disease, in addition to taking regular Therapeutic Method and treating, also to be noted
Meaning Diet Therapy, the nutrient that supply is sufficient, reasonably combined dietary structure.The present invention combine just dietetic nutrition regulation and in
Medicine composition makes a kind of health food granule having and supplementing the nutrients and assist treatment dual-use function, improves human immunity simultaneously
Power, defying age, eliminating toxin and beautifying the skin, nourishing taste, drop three-hypers, prevent and treat diabetes and anti-cancer, the function of the aspect such as anticancer.
Summary of the invention
The present invention is directed to the deficiency of existing product, and provide one to have extra-nutrition, auxiliary treatment, improve self increase
The wriggling of the intestines and stomach, curing the disease strengthens a kind of of the advantage such as body immunity simultaneously and prevents and treats the super of hypertensive heart disease based on collaborative absorption
Micro-nutrition prescription.
A kind of ultra micro nutrition prescription preventing and treating hypertensive heart disease based on collaborative absorption, described ultra micro nutrition prescription is by following
Raw material: Rhizoma Dioscoreae, Fructus Colocasiae Esculentae, Auricularia, dried shrimps, Semen Fagopyri Esculenti, Semen Maydis, the concentrated liquid of tradition Chinese medicine, vitamin, aminoacid and water are processed in right amount；
Described ultra micro nutrition prescription raw material according to weight is: Rhizoma Dioscoreae 2-5 part, Fructus Colocasiae Esculentae 1-3 part, Auricularia 3-5 part, dried shrimps 3-
5 parts, Semen Fagopyri Esculenti 10-20 part, Semen Maydis 3-10 part, the concentrated liquid of tradition Chinese medicine 3-8 part, vitamin 0.1-0.5 part, aminoacid 0.01-0.05 part
And water is appropriate；
The prescription of described the concentrated liquid of tradition Chinese medicine according to weight is: Herba Patriniae 15 parts, Caulis Sargentodoxae 15 parts, Semen Coicis 15 parts, Semen Persicae 10
Part, Retinervus Luffae Fructus 5 parts, 10 parts of wide Radix Rubiae, Radix Arnebiae (Radix Lithospermi) 10 parts, Fructus Crataegi 14 parts, Stigma Croci 1 part, Fructus Momordicae charantiae powder 7 parts, Herba Apii graveolentis 30 parts, Periostracum Cicadae
7.5 parts, Rhizoma Alismatis 3 parts, Rhizoma Coptidis 7.5 parts, Radix Angelicae Sinensis 7 parts, Flos Chrysanthemi 5 parts, Radix Angelicae Pubescentis 8 parts, Radix Cirsii Japonici 9 parts, 10 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 15
Part, Fructus Vitis viniferae 15 parts, Mel, water are appropriate.
Further；Described amino acid whose raw material according to weight is: L-arginine 0.01-0.08 part, Pidolidone
0.01-0.07 part, ASPARTIC ACID 0.01-0.03 part, L-Leu 0.01-0.02 part, ILE 0.01-0.03
Part, Valine 0.01-0.02 part.
Further；Described vitamin is: vitamin B1, vitamin B6, vitamin B12, vitamin A, vitamin D, dimension are raw
Whole mixing of element C and weight portion are identical.
The preparation processing method of a kind of ultra micro nutrition prescription preventing and treating hypertensive heart disease based on collaborative absorption, including following
Step；
Step one, new fresh Herba Dendrobii and Fructus Vitis viniferae are cleaned up, the fresh bar of screening high-quality Herba Dendrobii and Fructus Vitis viniferae, dry standby；
Step 2, new fresh Herba Dendrobii is put into rotating centrifugal juice extractor and carry out Herba Dendrobii juice and separate with fiber stand-by；Again by Fructus Vitis viniferae
Putting into blowing continuous way quick-freezing plant, by temperature be-40～the air of-30 DEG C makes Fructus Vitis viniferae according to the speed of 3～6m/s
Surface freezes, then carries out Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae detached job；By Semen Vitis viniferae through vacuum outgas, then use CO2Super
Supercritical fluid extraction, CO2The condition of supercritical fluid extraction is: extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time
30min, isolated Oleum Vitis viniferae is standby；
Step 3, Herba Dendrobii juice and Fructus Vitis viniferae meat are put into mixing drum Matrix Solution I；
Step 4, in hermetically sealed can add be equivalent to dendrobium fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and 5-10 times of weight
Distilled water, stirring is smashed to 100 mesh, preserves 24h, sterilizing at 37.5 DEG C～38.9 DEG C lower seals of temperature, filters, put into unglazed
Hermetically sealed can, keeps the temperature in hermetically sealed can, add the α of the 0.2%-0.5% being equivalent to dendrobium fiber and Pericarpium Vitis viniferae gross weight-
Amylase and the mixing enzyme preparation of protease；Enzymolysis 60 minutes under the conditions of pH6.5；After feed liquid after enzymolysis filters, filtrate concentrates
After Deproteinization, alcohol is washed, filtering residue deionized water wash；Feed liquid after enzymolysis is homogenizing, centrifugation under the supertension of 80～140MPa
Remove insoluble matter, obtain Matrix Solution II；
Step 5, Radix Angelicae Sinensis, Radix Angelicae Pubescentis, Rhizoma Coptidis, Air Bladder pseudosciaenae seu Acipenser are placed in the distilled water of 40-50 DEG C, soak 20-30min minute, heating
To 100 DEG C, holding pressure is at the micro-15min that boils of 0.2MPa, then is filtered by above-mentioned solution；Filtering solution adds under the conditions of 0.05MPa
Heat concentrates；By filtering solution but to less than 50 DEG C, filtering solution is pumped into the Alcohol-settling tank containing the ethanol that mass content is 85%,
After 30 minutes, alcohol deposit fluid is filtered by 0.3um filter, alcohol deposit fluid obtained above is heated under the conditions of 0.04MPa receipts
Alcohol, obtains Chinese medicine extraction liquid a；
Semen Coicis, Semen Persicae mix and blend are put into super micron mill, and super micron mill heating keeps temperature 80 degree 5-6 minute, carries out
Micronizing obtains the ultra micro mixing fine powders of 300-400 mesh；
Take Herba Patriniae, Caulis Sargentodoxae, Retinervus Luffae Fructus, wide Radix Rubiae, Radix Arnebiae (Radix Lithospermi), Fructus Crataegi, Stigma Croci, Fructus Momordicae charantiae powder, Herba Apii graveolentis, Periostracum Cicadae, Rhizoma Alismatis, Flos Chrysanthemi,
Radix Cirsii Japonici, after mix homogeneously adds 30-60 DEG C of warm water soaking 10 minutes, puts into reach in freezer, and-10～-20 DEG C, freezing 10-20 divides
Clock, forms freezing medicine block, freezing medicine block and ultra micro mixing fine powders boiling is extracted 3 times, adds 2 times amount water, temperature for the first time
Keep 100-120 DEG C, carry out infusion 20 minutes；Second time adds 4 times amount water, and temperature keeps 80-100 DEG C, carries out infusion 10 minutes；
Third time adds 2 times amount water, and temperature keeps 120-150 DEG C, carries out infusion 30 minutes, filters, and insulation is concentrated into the 1/ of original volume
2, add Chinese medicine extraction liquid a, obtain Matrix Solution III standby；
Step 6, by Matrix Solution I, Matrix Solution II, Matrix Solution III hybrid filtering concentrate add Oleum Vitis viniferae obtain Chinese medicine
Concentrated solution；
Step 7, weigh described dried shrimps, Semen Fagopyri Esculenti and Semen Maydis according to quantity, eluriate with clear water clean, after air-drying, use high speed pulverization respectively
Machine grinds, crosses 50 mesh sieves, and dried shrimps, Semen Fagopyri Esculenti and Semen Maydis powder are standby；
Taking Rhizoma Dioscoreae clean water clean, cutting, then with the saline soak 1h that mass concentration is 5%, taking-up drains, and is placed in
Smash to pieces after steaming in 0.05MPa autoclave, be dried, grind, obtain Rhizoma Dioscoreae powder standby；Auricularia is removed foreign material afterwash, does
Dry, then pulverized 50 mesh sieves, prepare Auricularia powder；
Step 8, take according to weight；The concentrated liquid of tradition Chinese medicine, vitamin, aminoacid, dried shrimps, Semen Fagopyri Esculenti and Semen Maydis powder, Rhizoma Dioscoreae
Powder, Auricularia powder；First vitamin, aminoacid, dried shrimps, Semen Fagopyri Esculenti and Semen Maydis powder, Rhizoma Dioscoreae powder and Auricularia powder are joined the concentrated liquid of tradition Chinese medicine
In, stir, obtain mixed powder, add 40～55 DEG C of hot water of 3-5 times of weight of mixed powder, heat-insulation soaking 2 hours, add weight
Percentage ratio is the yeast of 1.5-2%, ferments 2 hours, obtains fermentation mixed powder, the fermentation mixed powder modulated is carried out extruding puffing
Process.
Further；Described extruding puffing processes: extrusion temperature is 120-140 DEG C, and the charging rate of extruding puffing is 40-45
Kg/h, screw speed is 300-400rpm；By the product after expanding treatment through high speed disintegrator grinds, cross 100-120 mesh sieve,
Make ultra micro nutrition prescription powder.
Further；Described ultra micro nutrition prescription powder is dried 30 minutes at 40-50 DEG C, moisture≤1.5%；Particle diameter 1-
1.5mm。
Rhizoma Dioscoreae can promote that brain secretes dehydroepiandrosterone.Take dehydroepiandrosterone, sleep improvement can be made, happy, fill
Full vigor, it appears young, makes people good appetite etc., it is thus achieved that body-building, the effect of slow down aging.Rhizoma Dioscoreae has nourishing cell, strong
Change the effect such as endocrine, strong, the enhancing body hemopoietic function of tonification, can inducement interferon, improve body's immunity, improve anti-
Condition of disease power etc., to slow down aging process important role.Rhizoma Dioscoreae, rich in the trace element useful to human body, has and nourishes blood, mends
Brain, kidney tonifying, anti-ageing function of waiting for a long time.Rhizoma Dioscoreae has several mineral materials, the various trace elements such as such as ferrum, copper, zinc, manganese, calcium.Therefore
The effect the most only replenished the calcium, the also effect of iron supplement, zinc supplement.
Sweet pungent, the property of Fructus Colocasiae Esculentae property is put down, and returns intestinal, stomach warp；There is stomach reinforcing, reducing swelling and alleviating pain, wide intestinal, removing toxic substances, invigorating middle warmer liver and kidney tonifying, dissipate
Gas in knot, regulation, reduce phlegm, relieving constipation, stomach reinforcing spleen invigorating, the effect such as sperm adding and marrow healthing.In Fructus Colocasiae Esculentae rich in calcium, phosphorus, vitamin B group, potassium,
The Multiple components such as magnesium, Vc, sodium, carotene, ferrum, nicotinic acid, saponin.Its abundant nutritive value, has and strengthens exempting from of human body
The effect of epidemic disease function.Can be as the conventional medicated diet staple food of preventing and treating carcinoma.Its abundant vitamin can activate cells in vivo, accelerates
Metabolism, thus reach the purpose of fat-reducing.Fructus Colocasiae Esculentae contains a kind of natural polysaccharide plant colloid, energy appetite stimulator, helps
Digestion, has the effect of antidiarrheal；There are again the function of dietary fiber, energy loosening bowel to relieve constipation simultaneously, prevent constipation；And body can be improved resist
Condition of disease power, helps rehabilitation after being ill.
Auricularia have QI invigorating keep fit, nourishing kidney nourishing the stomach, the function such as invigorate blood circulation, it can anticoagulant, antithrombotic, blood fat reducing, Auricularia
Effect reduce blood and glue, vessel softening, make blood flowing dynamic smooth, reduce cardiovascular diseases and occur.Auricularia also has stronger absorption
Effect, often eats and is beneficial to make the rubbish of internal generation excrete in time, containing anti-tumor active substance, can enhancing body exempt from
Epidemic disease power, often eating can cancer-resisting.
Dried shrimps is nutritious, containing protein be fish, egg, several times to tens times of milk;Possibly together with abundant potassium, iodine, magnesium, phosphorus
Deng mineral and the composition such as vitamin A, aminophylline, and its meat is soft, easy to digest, to physical weakness and need after being ill to take good care of
People be fabulous food；Containing abundant magnesium, magnesium has important regulation effect to cardiomotility, can well protect painstaking effort
Guard system, it can reduce blood cholesterol level, prevents arteriosclerosis, simultaneously can also coronary artery dilator, be conducive to prevention
Hypertension and myocardial infarction；Dried small shrimps has sedation, is commonly used to treat neurasthenia, all diseases of autonomic nervous dysfunction.
Semen Maydis containing protein, fat, starch, vitamin B1, vitamin B2, vitamin A, carotene, cellulose and
The mineral such as calcium, phosphorus, ferrum, the health-care good product in coarse grain.Lung benefiting mind calming, spleen benefiting and stimulating the appetite, clearing heat and freeing strangury, diuresis is stopped blooding.To anti-cancer,
Cholesterol reducing, brain-strengthening have certain effect.Scalable nervous function, makes skin delicacy smooth, suppresses and delays wrinkle to produce.
The nutritional labeling of Semen Fagopyri Esculenti is mainly rich in protein, vitamin B group, and rutin class strengthening angiogenic substance, mineral are sought
Support element, abundant plant cellulose etc..Research display: often edible buckwheat is difficult to cause obesity, because Semen Fagopyri Esculenti is containing nutritious
Being worth phytoprotein high, that balance is good, this protein is difficult to change into fat in vivo, so not being easily caused fertilizer
Fat.Additionally contained in Semen Fagopyri Esculenti dietary fiber is that people often eat more than the octuple of main meal products face and rice, has good prevention just
Secret effect is the most edible useful to prevention colorectal cancer and obesity.
Vitamin B1, vitamin B6, vitamin B12, vitamin A, vitamin D, ascorbic whole mixing and weight
Part is identical；Amino acid whose raw material according to weight is: L-arginine 0.01-0.08 part, Pidolidone 0.01-0.07 part,
ASPARTIC ACID 0.01-0.03 part, L-Leu 0.01-0.02 part, ILE 0.01-0.03 part, Valine
0.01-0.02 part；The trace element such as vitamin and aminoacid, maintains healthy institute required by adding to supplement.
Herba Patriniae, acrid in the mouth, hardship, for effects such as heat-clearing and toxic substances removing, removing blood stasis and expelling pus.
Caulis Sargentodoxae, bitter in the mouth, flat, nontoxic, return Liver Channel, large intestine channel, for promoting blood circulation to remove obstruction in the collateral, relieve internal heat dissipating blood stasis, wind dispelling insecticide.
Semen Coicis, spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal.
Semen Persicae, blood stasis removing and clots absorbing, moisturize laxation.
Retinervus Luffae Fructus, sweet in the mouth, cool in nature.Return lung, liver, stomach warp.Dredge the meridian passage, heat-clearing and toxic substances removing, inducing diuresis to remove edema, hemostasis.
Wide Radix Rubiae, bitter in the mouth, cold in nature, GUIXIN, Liver Channel, enter blood system, can dissipate and can hold back, can rise and can drop;There is cooling blood for hemostasis, live
Blood and dissolving stasis, effect of heat-clearing and toxic substances removing.
Radix Arnebiae (Radix Lithospermi), removing heat from blood, invigorate blood circulation, heat clearing away, removing toxic substances.
Fructus Crataegi: Fructus Crataegi has an effect such as blood fat reducing, blood pressure, heart tonifying, arrhythmia, meanwhile, Fructus Crataegi be also spleen benefiting and stimulating the appetite,
Relieving dyspepsia, the good medicine of phlegm reduction of blood circulation promoting.
Stigma Croci: sweet in the mouth, property is put down.There is the intracellular oxygen metabolism function of enhancing, improve the hypoxia-bearing capability of heart, invigorating blood circulation
The stasis of blood, effect of removing pathogenic heat from blood and toxic substance from the body, heart is had certain protective role, and has and significantly press down the effect that cancer is anticancer.
Fructus Momordicae charantiae powder bitter in the mouth cold in nature, has clearing away summer-heat and dispels the effects such as heat, improving eyesight removing toxic substances, nourishing blood and invigorating qi, to calentura excessive thirst, heatstroke,
Dysentery, conjunctival congestion, carbuncle erysipelas, malignant boil etc. have dietary function.
Herba Apii graveolentis: calming liver and clearing heat, expelling wind and removing dampness, relieving restlessness subsides a swelling, cooling blood for hemostasis, and detoxify lung qi dispersing, key stomach profit blood, bowel relieving be convenient,
Nourishing the lung to arrest cough, reduce blood pressure, effect that brain-strengthening is calm.
Periostracum Cicadae, sweet in the mouth, salty, cool in nature.There is antibacterial, cold relieving, relieving convulsion, diuresis, dispelling wind and heat pathogens, relieving sore throat to recover voice, rash, improving eyesight
Nebula removing, endogenous wind stopping relieving convulsion.
Rhizoma Alismatis, sweet, light, cold in nature.Return kidney, bladder warp.Promoting diuresis to eliminate damp pathogen, expels the heat-evil, and changes turbid blood fat reducing.
Rhizoma Coptidis, heat clearing and damp drying, eliminating fire and detoxication, for damp and hot feeling of fullness, vomit, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire,
Dysphoria and insomnia.
Radix Angelicae Sinensis, sweet, pungent, warm, return liver, the heart, spleen channel, enrich blood；Invigorate blood circulation；Menstruction regulating and pain relieving；Moisturize laxation.
Flos Chrysanthemi, bitter in the mouth, pungent, cool, heat-clearing and toxic substances removing, wind-dispelling heat-dissipating, dissipating blood stasis, improving eyesight, blood pressure lowering.
Radix Angelicae Pubescentis: bitter, tepor, pungent.Return kidney, bladder warp.Function cures mainly: expelling wind and dampness, dispersing cold for relieving pain.
Air Bladder pseudosciaenae seu Acipenser, sweet, flat, nontoxic.Sweet in the mouth, temperature.Enter kidney.The kidney invigorating and essence nourishing, nourishes muscle arteries and veins, hemostasis, dissipating blood stasis, detumescence, controls kidney
Empty spermatorrhea.
Radix Cirsii Japonici: sweet in the mouth, slightly cool in nature.There is hemostasis, blood pressure lowering, antibacterial, effect of clots absorbing detumescence, be used for spitting blood, spitting of blood, nosebleed
Blood, has blood in stool, hematuria, and skin infection swells and ache, nephritis, eczema etc..
Mel has He Yingwei, moistens internal organs, and logical three is burnt, adjusts effect of taste.
Fructus Vitis viniferae nutritive value is the highest, containing mineral calcium, potassium, phosphorus, ferrum and multivitamin B1, vitamin in Fructus Vitis viniferae
B2, vitamin B6, vitamin C and Citrin etc., possibly together with the aminoacid of multiple needed by human body, multiple fruit acid contributes to digestion,
Suitably eat a little Fructus Vitis viniferae more, can be good for Pi stomach function regulating, dry and cracked to tongue body, overfatigue is of great advantage and has.
Being share by the natural tradition medicinal and edible Chinese medicine above with multiple health care, clots absorbing leads to stagnant, the Hang Shui that purifies the blood, controls
Treat hypertensive heart disease.Improve body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, the merit of resisting fatigue.By a large amount of real
Test the proportioning screening each component, scientific and reasonable；And whole preparation technology is rationally and extract drugs rate efficiency is high, can protect well
Stay the effective ingredient in raw material, do not bring any impurity into, have no side effect.
The invention has the beneficial effects as follows:
1, the ultra micro nutrition prescription of the present invention, has promoting the production of body fluid to quench thirst, gastric acid secretion, helps digest, and health body-building alleviates tired
Labor, improves immunity of organisms, the effect of vitimin supplement, has the rehabilitative action of uniqueness.
2, the present invention is rich in anthocyanidin, it is possible to protection human body is from the damage of free radical, it is possible to strengthens blood vessel elasticity, relax
Blood vessel, increases systemic blood circulation, has certain blood pressure reduction effect；Immune system ability can be strengthened, there is strong anti-oxidation, resist
Suddenly change, alleviate the function such as hepatosis, protection cardiovascular；
3, add the concentrated liquid of tradition Chinese medicine there is clots absorbing to lead to stagnant, the row water that purifies the blood, treatment hypertensive heart disease, improve body immunity, anti-
The functions such as aging, eliminating toxin and beautifying the skin, nourishing taste, resisting fatigue.
4, the product that the production technology of the present invention and preparation method draw, rich in dendrobium polysaccharide, dendrobium polysaccharide composition has
Increase the remarkable effect of the immune cell functions such as T, bone-marrow-derived lymphocyte, macrophage and natural killer cell (NK), to cancer patient
Have dramatically increase T cell immunologic function effect (T cell participate in immunne response killing tumor cell, suppression tumor growth
In play an important role), the macrophage of activation can direct killing tumor cell, to immune system play many regulation make
With, there is the highest health care and medical value, improve self and increase the wriggling of the intestines and stomach, cure the disease and strengthen human immunity simultaneously
Power.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, in order to those skilled in the art knows more about
The present invention, but and it is not so limited the present invention.
Embodiment 1
A kind of ultra micro nutrition prescription preventing and treating hypertensive heart disease based on collaborative absorption, described ultra micro nutrition prescription is by following former
Material: Rhizoma Dioscoreae, Fructus Colocasiae Esculentae, Auricularia, dried shrimps, Semen Fagopyri Esculenti, Semen Maydis, the concentrated liquid of tradition Chinese medicine, vitamin, aminoacid and water are processed in right amount；
Described ultra micro nutrition prescription raw material according to weight is: Rhizoma Dioscoreae 5 parts, Fructus Colocasiae Esculentae 1 part, 5 parts of Auricularia, 5 parts of dried shrimps, Semen Fagopyri Esculenti
15 parts, Semen Maydis 10 parts, the concentrated liquid of tradition Chinese medicine 8 parts, vitamin 0.1 part, 0.01 part of aminoacid and water are appropriate；
The prescription of described the concentrated liquid of tradition Chinese medicine according to weight is: Herba Patriniae 15 parts, Caulis Sargentodoxae 15 parts, Semen Coicis 15 parts, Semen Persicae 10
Part, Retinervus Luffae Fructus 5 parts, 10 parts of wide Radix Rubiae, Radix Arnebiae (Radix Lithospermi) 10 parts, Fructus Crataegi 14 parts, Stigma Croci 1 part, Fructus Momordicae charantiae powder 7 parts, Herba Apii graveolentis 30 parts, Periostracum Cicadae
7.5 parts, Rhizoma Alismatis 3 parts, Rhizoma Coptidis 7.5 parts, Radix Angelicae Sinensis 7 parts, Flos Chrysanthemi 5 parts, Radix Angelicae Pubescentis 8 parts, Radix Cirsii Japonici 9 parts, 10 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 15
Part, Fructus Vitis viniferae 15 parts, Mel, water are appropriate.
Described amino acid whose raw material according to weight is: L-arginine 0.01 part, Pidolidone 0.02 part, L-Tianmen
Winter propylhomoserin 0.01 part, L-Leu 0.01 part, ILE 0.01 part, Valine 0.01 part.Described vitamin is: dimension is raw
Element B1, vitamin B6, vitamin B12, vitamin A, vitamin D, ascorbic whole mixing and weight portion are identical.
The preparation processing method of a kind of ultra micro nutrition prescription preventing and treating hypertensive heart disease based on collaborative absorption, including following
Step；
Step one, new fresh Herba Dendrobii and Fructus Vitis viniferae are cleaned up, the fresh bar of screening high-quality Herba Dendrobii and Fructus Vitis viniferae, dry standby；
Step 2, new fresh Herba Dendrobii is put into rotating centrifugal juice extractor and carry out Herba Dendrobii juice and separate with fiber stand-by；Again by Fructus Vitis viniferae
Putting into blowing continuous way quick-freezing plant, by temperature be-40～the air of-30 DEG C makes Fructus Vitis viniferae according to the speed of 3～6m/s
Surface freezes, then carries out Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae detached job；By Semen Vitis viniferae through vacuum outgas, then use CO2Super
Supercritical fluid extraction, CO2The condition of supercritical fluid extraction is: extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time
30min, isolated Oleum Vitis viniferae is standby；
Step 3, Herba Dendrobii juice and Fructus Vitis viniferae meat are put into mixing drum Matrix Solution I；
Step 4, in hermetically sealed can add be equivalent to dendrobium fiber and the Mel of Pericarpium Vitis viniferae gross weight 30% and the distillation of 8 times of weight
Water, stirring is smashed to 100 mesh, is preserved 24h, sterilizing at 37.5 DEG C～38.9 DEG C lower seals of temperature, filter, put into unglazed sealing
Tank, keeps the temperature in hermetically sealed can, at the α-amylase and the egg that add be equivalent to dendrobium fiber and Pericarpium Vitis viniferae gross weight 0.3%
The mixing enzyme preparation of white enzyme；Enzymolysis 60 minutes under the conditions of pH6.5；After feed liquid after enzymolysis filters, filtrate concentrates alcohol after Deproteinization
Wash, filtering residue deionized water wash；Feed liquid after enzymolysis is homogenizing under the supertension of 80MPa, and insoluble matter is removed in centrifugation, obtains base
Liquid solution II；
Step 5, Radix Angelicae Sinensis, Radix Angelicae Pubescentis, Rhizoma Coptidis, Air Bladder pseudosciaenae seu Acipenser are placed in the distilled water of 40-50 DEG C, soak 20-30min minute, heating
To 100 DEG C, holding pressure is at the micro-15min that boils of 0.2MPa, then is filtered by above-mentioned solution；Filtering solution adds under the conditions of 0.05MPa
Heat concentrates；By filtering solution but to less than 50 DEG C, filtering solution is pumped into the Alcohol-settling tank containing the ethanol that mass content is 85%,
After 30 minutes, alcohol deposit fluid is filtered by 0.3um filter, alcohol deposit fluid obtained above is heated under the conditions of 0.04MPa receipts
Alcohol, obtains Chinese medicine extraction liquid a；
Semen Coicis, Semen Persicae mix and blend are put into super micron mill, and super micron mill heating keeps temperature 80 degree 6 minutes, surpasses
Crushing of Ultrafine obtains the ultra micro mixing fine powders of 300 mesh；
Take Herba Patriniae, Caulis Sargentodoxae, Retinervus Luffae Fructus, wide Radix Rubiae, Radix Arnebiae (Radix Lithospermi), Fructus Crataegi, Stigma Croci, Fructus Momordicae charantiae powder, Herba Apii graveolentis, Periostracum Cicadae, Rhizoma Alismatis, Flos Chrysanthemi,
Radix Cirsii Japonici, mix homogeneously adds 45 DEG C of warm water soaking after 10 minutes, puts into reach in freezer ,-20 DEG C of freezings 10 minutes, forms freezing medicine
Block, extracts freezing medicine block and ultra micro mixing fine powders boiling 3 times, adds 2 times amount water for the first time, and temperature keeps 100 DEG C, carries out
Infusion 20 minutes；Second time adds 4 times amount water, and temperature keeps 80-100 DEG C, carries out infusion 10 minutes；Third time adds 2 times amount water, temperature
Degree keeps 135 DEG C, carries out infusion 30 minutes, filters, and insulation is concentrated into the 1/2 of original volume, adds Chinese medicine extraction liquid a, obtains base
Liquid solution III is standby；
Step 6, by Matrix Solution I, Matrix Solution II, Matrix Solution III hybrid filtering concentrate add Oleum Vitis viniferae obtain Chinese medicine
Concentrated solution；
Step 7, weigh described dried shrimps, Semen Fagopyri Esculenti and Semen Maydis according to quantity, eluriate with clear water clean, after air-drying, use high speed pulverization respectively
Machine grinds, crosses 50 mesh sieves, and dried shrimps, Semen Fagopyri Esculenti and Semen Maydis powder are standby；
Taking Rhizoma Dioscoreae clean water clean, cutting, then with the saline soak 1h that mass concentration is 5%, taking-up drains, and is placed in
Smash to pieces after steaming in 0.05MPa autoclave, be dried, grind, obtain Rhizoma Dioscoreae powder standby；Auricularia is removed foreign material afterwash, does
Dry, then pulverized 50 mesh sieves, prepare Auricularia powder；
Step 8, take according to weight；The concentrated liquid of tradition Chinese medicine, vitamin, aminoacid, dried shrimps, Semen Fagopyri Esculenti and Semen Maydis powder, Rhizoma Dioscoreae
Powder, Auricularia powder；First vitamin, aminoacid, dried shrimps, Semen Fagopyri Esculenti and Semen Maydis powder, Rhizoma Dioscoreae powder and Auricularia powder are joined the concentrated liquid of tradition Chinese medicine
In, stir, obtain mixed powder, add 45 DEG C of hot water of 3-5 times of weight of mixed powder, heat-insulation soaking 2 hours, add weight percent
Ratio is the yeast of 1.5%, ferments 2 hours, obtains fermentation mixed powder, the fermentation mixed powder modulated is carried out extruding puffing process.
Described extruding puffing processes: extrusion temperature is 120 DEG C, and the charging rate of extruding puffing is 45kg/h, screw speed
For 350rpm；By the product after expanding treatment through high speed disintegrator grinds, cross 110 mesh sieves, make ultra micro nutrition prescription powder.Institute
State ultra micro nutrition prescription powder to dry 30 minutes at 45 DEG C, moisture≤1.5%；Particle diameter 1-1.5mm.
Comparative example 2
A kind of ultra micro nutrition prescription preventing and treating hypertensive heart disease based on collaborative absorption, processing method and other nutritional labeling (mountains
Medicine, Fructus Colocasiae Esculentae, Auricularia, dried shrimps, Semen Fagopyri Esculenti, Semen Maydis, vitamin, aminoacid) with embodiment 1, the prescription of described the concentrated liquid of tradition Chinese medicine according to
Weight is: Herba Patriniae 15 parts, Caulis Sargentodoxae 15 parts, Semen Coicis 15 parts, 10 parts of Semen Persicae, Retinervus Luffae Fructus 5 parts, 10 parts of wide Radix Rubiae, Radix Arnebiae (Radix Lithospermi)
10 parts, Fructus Crataegi 14 parts, Stigma Croci 1 part, Fructus Momordicae charantiae powder 7 parts, Herba Apii graveolentis 30 parts, Periostracum Cicadae 7.5 parts, Rhizoma Alismatis 3 parts, Rhizoma Coptidis 7.5 parts, Radix Angelicae Sinensis 7
Part, Flos Chrysanthemi 5 parts, Radix Angelicae Pubescentis 8 parts, Radix Cirsii Japonici 9 parts, new fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, Mel, water are appropriate；Compare not with embodiment 1
Containing Air Bladder pseudosciaenae seu Acipenser composition.
Comparative example 3
A kind of ultra micro nutrition prescription preventing and treating hypertensive heart disease based on collaborative absorption, other nutritional labelings are with embodiment 1, Chinese medicine
The prescription of concentrated solution according to weight is: Herba Patriniae 15 parts, Caulis Sargentodoxae 15 parts, Semen Coicis 15 parts, 10 parts of Semen Persicae, Retinervus Luffae Fructus 5 parts,
Wide 10 parts of Radix Rubiae, Radix Arnebiae (Radix Lithospermi) 10 parts, Fructus Crataegi 14 parts, Stigma Croci 1 part, Fructus Momordicae charantiae powder 7 parts, Herba Apii graveolentis 30 parts, Periostracum Cicadae 7.5 parts, Rhizoma Alismatis 3 parts,
Rhizoma Coptidis 7.5 parts, Radix Angelicae Sinensis 7 parts, Flos Chrysanthemi 5 parts, Radix Angelicae Pubescentis 8 parts, Radix Cirsii Japonici 9 parts, 10 parts of Air Bladder pseudosciaenae seu Acipenser, water are appropriate.Compare with embodiment 1 without new
Fresh Herba Dendrobii, Fructus Vitis viniferae, honey component and the Matrix Solution I being processed into, Matrix Solution II.Preparation for processing is: embodiment 1 adds
Work step 5, step 7 and step 8.
Comparative example 4
A kind of ultra micro nutrition prescription preventing and treating hypertensive heart disease based on collaborative absorption, compares with embodiment 1 without (Rhizoma Dioscoreae, taro
Head, Auricularia, dried shrimps, Semen Fagopyri Esculenti, Semen Maydis) etc. nutritional labeling；Other are the most same as in Example 1.
Comparative example 5
A kind of ultra micro nutrition prescription preventing and treating hypertensive heart disease based on collaborative absorption, compares without aminoacid, dimension with embodiment 1
The trace element such as raw element；Other are the most same as in Example 1.
Comparative example 6
A kind of ultra micro nutrition prescription preventing and treating hypertensive heart disease based on collaborative absorption, compares with embodiment 1: without (Rhizoma Dioscoreae, taro
Head, Auricularia, dried shrimps, Semen Fagopyri Esculenti, Semen Maydis) etc. nutritional labeling and the trace element such as aminoacid, vitamin；Other all with embodiment 1 phase
With.
Comparative example 7
A kind of ultra micro nutrition prescription preventing and treating hypertensive heart disease based on collaborative absorption, compares with embodiment 1: except for the difference that, system
Take the concentrated liquid of tradition Chinese medicine, by medical material add water direct boiling method prepare.
Clinical experiment divides three parts:
(1) animal acute toxicity and chronic toxicity experiment:
1, animal acute toxicity test
Medicine: the embodiment of the present invention 1 and remaining comparative example's gained nutritive powder.
Experimental animal: regular grade NIH mice, body weight 18g ± 2g, male and female half and half.
Method and result:
By each for nutritional granular 50g, adding water, the nutritional granular powder made is stuck with paste.Experiment mice is randomly divided into 7 groups of male and female half and half,
7 kinds of nutritional granular powder of feeding are stuck with paste respectively, volume 1ml/10g body weight, and close observation 8 hours is also noted down, and continue to observe 7 days；7
In it, mice is without death, and behavior is active, and food ration is as usual, and hair color light is without loose dirt, without fainting from fear addicted to saliva, eye, mouth, nose, ear and
Crissum secretions without exception, without the rotten toe that docks.Respectively from 7 groups select 2 execution, finding of naked eye: the heart, liver, lung, gastric and
The important organs such as thymus, no abnormality seen changes, shows that two kinds of these nutritive powders are all without acute toxicity.
2, long-term toxicity test for animals
Medicine: the embodiment of the present invention 1 and remaining comparative example's gained nutritional granular nutritional granular powder made that adds water is stuck with paste.
Animal: regular grade SD rat, body weight 200g ± 10g, male and female half and half.
Method and result:
The configuration that 7 kinds of nutritional granular powder are stuck with paste: be divided into high, medium and low three dosage groups, respectively the 200 of edible for patients amount, 100,
50g；Experimental mouse is randomly divided into 7 groups, and the nutritional granular powder that feeding modulates continuously respectively is stuck with paste, and continuous feeding 40 days is observed dynamic
Thing general toxic reaction and the order of severity, place after death by rule of operation check each position, and carry out hematology, ALT, BUN and
The pathological examination of the main organs such as the heart, liver, spleen, lung, kidney, stomach；
Through long-term feeding, all there is not toxic reaction in two groups of rats.Growth promoter is good.Macroscopic appearance and main organs have no
Abnormal.Peripheral hemogram and Serum ALT, BUN compare with matched group without pathologic change.The pathological replacement heart, liver, spleen, lung, kidney, stomach
Deng the most significant change, it is understood that through proved by pathology, 7 kinds of nutritional granular powder are stuck with paste animal without chronic toxicity table
Existing.
By two above toxicity test, it was demonstrated that the nutritional granular that the present invention is made by embodiment 1 and comparative example is
Safety, have no side effect, can be used to clinical patients is carried out clinical trial.
3, embodiment of the present invention using effect investigation:
(1) investigation method:
1. crowd is used: general population
2. the time is used: 90 days
3. number of users: 100 people
4. using method: the most soaked 500 mL
5. index: the most tired, heart spleen blood stasis can not change water circulation of qi promoting, face foot edema, tongue dirty coating is dim, food stagnation does not disappears, do not think drink
The hypertensive heart disease clinical symptom disappearance such as food, middle gas not province are effective；Drink rear hypertensive heart disease clinical symptom remission note
For effectively.Drink rear hypertensive heart disease clinical symptoms not alleviate, and there do not have any comfort to be then designated as to be invalid.
(2) survey result: survey result is shown in Table 1.
Table 1 each embodiment using effect application form
Conclusion:
Be can be seen that by the data of comparative example 2, the ratio of invalid number is compared with embodiment 1, adds 8%, shows Air Bladder pseudosciaenae seu Acipenser
In Chinese medicine formula, serve priming return through, the function heightened the effect of a treatment, improve the human body assimilation effect to medicine；Bolus for invigorating kidney and improving,
Kidney has the function that Tibetan, main store essential substances, main growth promoter and reproduction are taken the photograph by main department, the liquefaction of main water is thanked.Normal renal function then vital essence fills,
The all dirty negative and positive of whole body disease the most prosperous, all disappears；Conversely, as the impact or worn with age of various paathogenic factors, renal function can be caused and lose
Often.Owing to Air Bladder pseudosciaenae seu Acipenser is a kind of rich sticking material, containing the nutritional labelings such as profuse protein, vitamin, mineral, institute
Have with, fish bubble that the kidney invigorating waist knee joint empty, strong, yin nourishing benefit be smart and the effect of moist skin care.For having a delicate constitution, Kidney-Yin loss, spirit
The personage overwork, overworked is the most suitable.
The data compared with embodiment 1 by comparative example 3 can be seen that, without new fresh Herba Dendrobii, Fructus Vitis viniferae, honey component and
Matrix Solution I, the Matrix Solution II being processed into；The ratio of invalid number is compared with embodiment 1, adds 7 times；And it is effective
The average time of rate, having compared many 5 days than embodiment 1, (i.e. feeling effective, the average time of clinical symptom disappearance is many 5
My god；This shows that the preparation for processing of the present invention makes the concentrated liquid of tradition Chinese medicine prescription and the composition such as water soluble dietary fiber and Oleum Vitis viniferae
Between create mutually collaborative pharmacological action, water soluble dietary fiber increases effect of the wriggling of the intestines and stomach and promotes that human body is to medicine
The absorption of composition, it is ensured that metabolic waste normally excretes, the anthocyanidin additionally contained in Pericarpium Vitis viniferae, resveratrol, have strong
Antioxidation, mutation, alleviate hepatosis, the protection function such as cardiovascular, strengthen immune system ability；Associate with raising with Chinese medicine
Assimilation effect, improves the mouthfeel of Chinese medicine simultaneously, meticulously configuring and the extraction of at utmost ingredient through the present invention, this
Bright traditional Chinese drug inspissation formula of liquid and preparation method occur in that beat all technique effect.
Compared with embodiment 1 by the data of comparative example 4 and can be seen that, without (Rhizoma Dioscoreae, Fructus Colocasiae Esculentae, Auricularia, dried shrimps, buckwheat
Wheat, Semen Maydis) etc. nutritional labeling, the ratio of invalid number and embodiment 1 compare, add 10 times, and the number of obvious effective rate also under
Drop, the drug effect of the nutritional labeling the concentrated liquid of tradition Chinese medicine such as (Rhizoma Dioscoreae, Fructus Colocasiae Esculentae, Auricularia, dried shrimps, Semen Fagopyri Esculenti, Semen Maydis) of showing the present invention it
Between create mutually collaborative pharmacological action, the nutrient that supply human body is sufficient, dietary structure is reasonably combined, nutritional labeling
Supplement the necessary energy of human body, reach balanced nutritious, promote the health absorption to medicine.
Being compared with embodiment 1 by comparative example 5, inefficiency number is 8 times of embodiment 1, aminoacid, vitamin
Deng trace element；Nutrient and trace element that supplementary needed by human body is wanted regulate physiological function, are catalyzed metabolic adsorption medicine
During have highly important effect.
The data compared with embodiment 1 by comparative example 6 can be seen that, without (Rhizoma Dioscoreae, Fructus Colocasiae Esculentae, Auricularia, dried shrimps, buckwheat
Wheat, Semen Maydis) etc. nutritional labeling and the trace element such as aminoacid, vitamin；Inefficiency number is 15 times of embodiment 1 and effectively
Rate number also declines nearly 20%；And the average time of obvious effective rate, compared many 7 days than embodiment 1 (i.e. feel effective people,
The average time of clinical symptom disappearance is many 7 days；Illustrate that nutritional labeling and trace element are sent out during human body medicine absorbs
Wave and important synergism, greatly promoted human body and medicine and the absorption of nutrition, quickening human body are recovered.
The data compared with embodiment 1 by comparative example 7 can be seen that, medical material adds water direct boiling method and the present invention
Chinese medicine preparation method compare, the preparation method of the present invention, the extraction of drug effect is far longer than traditional adding water and directly boils
Method, the extraction degree of active ingredient has had huge raising.
In sum, a kind of ultra micro nutrition prescription preventing and treating hypertensive heart disease based on collaborative absorption that the present invention provides
Preparation processing method, clots absorbing leads to stagnant, the row water that purifies the blood, mutually assists between treatment hypertensive heart disease and nutritional labeling and trace element
Same pharmacological action, the nutrient that supply human body is sufficient, dietary structure is reasonably combined, and it is necessary that nutritional labeling supplements human body
Energy, reaches balanced nutritious, promotes the health absorption to medicine, and all raw materials are all from medicine-food two-purpose natural plants, nontoxic pair
Effect.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For Yuan, under the premise without departing from the principles of the invention, it is also possible to make some improvements and modifications, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (6)
1. the ultra micro nutrition prescription preventing and treating hypertensive heart disease based on collaborative absorption, it is characterised in that described ultra micro nutrition
Prescription is by following raw material: Rhizoma Dioscoreae, Fructus Colocasiae Esculentae, Auricularia, dried shrimps, Semen Fagopyri Esculenti, Semen Maydis, the concentrated liquid of tradition Chinese medicine, vitamin, aminoacid and water are appropriate
It is processed into；
Described ultra micro nutrition prescription raw material according to weight is: Rhizoma Dioscoreae 2-5 part, Fructus Colocasiae Esculentae 1-3 part, Auricularia 3-5 part, dried shrimps 3-
5 parts, Semen Fagopyri Esculenti 10-20 part, Semen Maydis 3-10 part, the concentrated liquid of tradition Chinese medicine 3-8 part, vitamin 0.1-0.5 part, aminoacid 0.01-0.05 part
And water is appropriate；
The prescription of described the concentrated liquid of tradition Chinese medicine according to weight is: Herba Patriniae 15 parts, Caulis Sargentodoxae 15 parts, Semen Coicis 15 parts, Semen Persicae 10
Part, Retinervus Luffae Fructus 5 parts, 10 parts of wide Radix Rubiae, Radix Arnebiae (Radix Lithospermi) 10 parts, Fructus Crataegi 14 parts, Stigma Croci 1 part, Fructus Momordicae charantiae powder 7 parts, Herba Apii graveolentis 30 parts, Periostracum Cicadae
7.5 parts, Rhizoma Alismatis 3 parts, Rhizoma Coptidis 7.5 parts, Radix Angelicae Sinensis 7 parts, Flos Chrysanthemi 5 parts, Radix Angelicae Pubescentis 8 parts, Radix Cirsii Japonici 9 parts, 10 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 15
Part, Fructus Vitis viniferae 15 parts, Mel, water are appropriate.
A kind of ultra micro nutrition prescription preventing and treating hypertensive heart disease based on collaborative absorption the most according to claim 1, it is special
Levying and be, described amino acid whose raw material according to weight is: L-arginine 0.01-0.08 part, Pidolidone 0.01-0.07
Part, ASPARTIC ACID 0.01-0.03 part, L-Leu 0.01-0.02 part, ILE 0.01-0.03 part, Valine
0.01-0.02 part.
A kind of ultra micro nutrition prescription preventing and treating hypertensive heart disease based on collaborative absorption the most according to claim 1, it is special
Levying and be, described vitamin is: vitamin B1, vitamin B6, vitamin B12, vitamin A, vitamin D, ascorbic entirely
Portion's mixing and weight portion are identical.
4. prevent and treat a preparation processing method for the ultra micro nutrition prescription of hypertensive heart disease based on collaborative absorption, its feature exists
In, comprise the following steps；
Step one, new fresh Herba Dendrobii and Fructus Vitis viniferae are cleaned up, the fresh bar of screening high-quality Herba Dendrobii and Fructus Vitis viniferae, dry standby；
Step 2, new fresh Herba Dendrobii is put into rotating centrifugal juice extractor and carry out Herba Dendrobii juice and separate with fiber stand-by；Again by Fructus Vitis viniferae
Putting into blowing continuous way quick-freezing plant, by temperature be-40～the air of-30 DEG C makes Fructus Vitis viniferae according to the speed of 3～6m/s
Surface freezes, then carries out Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae detached job；By Semen Vitis viniferae through vacuum outgas, then use CO2Super
Supercritical fluid extraction, CO2The condition of supercritical fluid extraction is: extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time
30min, isolated Oleum Vitis viniferae is standby；
Step 3, Herba Dendrobii juice and Fructus Vitis viniferae meat are put into mixing drum Matrix Solution I；
Step 4, in hermetically sealed can add be equivalent to dendrobium fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and 5-10 times of weight
Distilled water, stirring is smashed to 100 mesh, preserves 24h, sterilizing at 37.5 DEG C～38.9 DEG C lower seals of temperature, filters, put into unglazed
Hermetically sealed can, keeps the temperature in hermetically sealed can, add the α of the 0.2%-0.5% being equivalent to dendrobium fiber and Pericarpium Vitis viniferae gross weight-
Amylase and the mixing enzyme preparation of protease；Enzymolysis 60 minutes under the conditions of pH6.5；After feed liquid after enzymolysis filters, filtrate concentrates
After Deproteinization, alcohol is washed, filtering residue deionized water wash；Feed liquid after enzymolysis is homogenizing, centrifugation under the supertension of 80～140MPa
Remove insoluble matter, obtain Matrix Solution II；
Step 5, Radix Angelicae Sinensis, Radix Angelicae Pubescentis, Rhizoma Coptidis, Air Bladder pseudosciaenae seu Acipenser are placed in the distilled water of 40-50 DEG C, soak 20-30min minute, heating
To 100 DEG C, holding pressure is at the micro-15min that boils of 0.2MPa, then is filtered by above-mentioned solution；Filtering solution adds under the conditions of 0.05MPa
Heat concentrates；By filtering solution but to less than 50 DEG C, filtering solution is pumped into the Alcohol-settling tank containing the ethanol that mass content is 85%,
After 30 minutes, alcohol deposit fluid is filtered by 0.3um filter, alcohol deposit fluid obtained above is heated under the conditions of 0.04MPa receipts
Alcohol, obtains Chinese medicine extraction liquid a；
Semen Coicis, Semen Persicae mix and blend are put into super micron mill, and super micron mill heating keeps temperature 80 degree 5-6 minute, carries out
Micronizing obtains the ultra micro mixing fine powders of 300-400 mesh；
Take Herba Patriniae, Caulis Sargentodoxae, Retinervus Luffae Fructus, wide Radix Rubiae, Radix Arnebiae (Radix Lithospermi), Fructus Crataegi, Stigma Croci, Fructus Momordicae charantiae powder, Herba Apii graveolentis, Periostracum Cicadae, Rhizoma Alismatis, Flos Chrysanthemi,
Radix Cirsii Japonici, after mix homogeneously adds 30-60 DEG C of warm water soaking 10 minutes, puts into reach in freezer, and-10～-20 DEG C, freezing 10-20 divides
Clock, forms freezing medicine block, freezing medicine block and ultra micro mixing fine powders boiling is extracted 3 times, adds 2 times amount water, temperature for the first time
Keep 100-120 DEG C, carry out infusion 20 minutes；Second time adds 4 times amount water, and temperature keeps 80-100 DEG C, carries out infusion 10 minutes；
Third time adds 2 times amount water, and temperature keeps 120-150 DEG C, carries out infusion 30 minutes, filters, and insulation is concentrated into the 1/ of original volume
2, add Chinese medicine extraction liquid a, obtain Matrix Solution III standby；
Step 6, by Matrix Solution I, Matrix Solution II, Matrix Solution III hybrid filtering concentrate add Oleum Vitis viniferae obtain Chinese medicine
Concentrated solution；
Step 7, weigh described dried shrimps, Semen Fagopyri Esculenti and Semen Maydis according to quantity, eluriate with clear water clean, after air-drying, use high speed pulverization respectively
Machine grinds, crosses 50 mesh sieves, and dried shrimps, Semen Fagopyri Esculenti and Semen Maydis powder are standby；
Taking Rhizoma Dioscoreae clean water clean, cutting, then with the saline soak 1h that mass concentration is 5%, taking-up drains, and is placed in
Smash to pieces after steaming in 0.05MPa autoclave, be dried, grind, obtain Rhizoma Dioscoreae powder standby；Auricularia is removed foreign material afterwash, does
Dry, then pulverized 50 mesh sieves, prepare Auricularia powder；
Step 8, take according to weight；The concentrated liquid of tradition Chinese medicine, vitamin, aminoacid, dried shrimps, Semen Fagopyri Esculenti and Semen Maydis powder, Rhizoma Dioscoreae
Powder, Auricularia powder；First vitamin, aminoacid, dried shrimps, Semen Fagopyri Esculenti and Semen Maydis powder, Rhizoma Dioscoreae powder and Auricularia powder are joined the concentrated liquid of tradition Chinese medicine
In, stir, obtain mixed powder, add 40～55 DEG C of hot water of 3-5 times of weight of mixed powder, heat-insulation soaking 2 hours, add weight
Percentage ratio is the yeast of 1.5-2%, ferments 2 hours, obtains fermentation mixed powder, the fermentation mixed powder modulated is carried out extruding puffing
Process；By the product after expanding treatment through high speed disintegrator grinds, cross 100-120 mesh sieve, make ultra micro nutrition prescription powder.
The preparation of a kind of ultra micro nutrition prescription preventing and treating hypertensive heart disease based on collaborative absorption the most according to claim 4
Processing method, it is characterised in that described extruding puffing processes: extrusion temperature is 120-140 DEG C, and the charging rate of extruding puffing is
40-45 kg/h, screw speed is 300-400rpm.
The preparation of a kind of ultra micro nutrition prescription preventing and treating hypertensive heart disease based on collaborative absorption the most according to claim 5
Processing method, it is characterised in that described ultra micro nutrition prescription powder is dried 30 minutes at 40-50 DEG C, moisture≤1.5%；Particle diameter 1-
1.5mm。
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| CN101138686A (en) * | 2007-07-23 | 2008-03-12 | 沈军 | Method for extracting active ingredient of natural product and uses thereof |
| CN103392758A (en) * | 2013-06-30 | 2013-11-20 | 安徽省凤宝粮油食品（集团）有限公司 | Flour for steamed buns for hypertension patients and preparing method thereof |
| CN103656345A (en) * | 2013-11-26 | 2014-03-26 | 韩必芝 | Tortoise plastron couch grass root granules and preparation method thereof |
| CN104171131A (en) * | 2014-08-04 | 2014-12-03 | 安徽新津铁皮石斛开发有限公司 | Dendrobium officinale and jasmine tea beverage and preparation method thereof |
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| CN109527372A (en) * | 2018-12-29 | 2019-03-29 | 朱仁民 | A kind of multidimensional paddy flour electuary and preparation method thereof that can nourish the vital organs of the human body |
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Application publication date: 20161207 |