CN106174461A - A kind of nutrient formulation nano-particle preventing and treating Sheehan syndrome and preparation processing method - Google Patents
A kind of nutrient formulation nano-particle preventing and treating Sheehan syndrome and preparation processing method Download PDFInfo
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- CN106174461A CN106174461A CN201610234253.4A CN201610234253A CN106174461A CN 106174461 A CN106174461 A CN 106174461A CN 201610234253 A CN201610234253 A CN 201610234253A CN 106174461 A CN106174461 A CN 106174461A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of nutrient formulation nano-particle preventing and treating Sheehan syndrome, be made up of the raw material of following weight portion: Herba Cistanches 8 parts, Fructus Lycii 12 parts, 12 parts of Radix Glycyrrhizae, Fructus Ligustri Lucidi 12 parts, the Cortex Eucommiae 12 parts, Herba Cynomorii 8 parts, Semen Cuscutae 10 parts, Rhizoma Chuanxiong 10 parts, the Radix Astragali 15 parts, Carapax Trionycis 15 parts, Herba Epimedii 15 parts, 10 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 10 20 parts, Fructus Vitis viniferae 10 20 parts, Mel, water is appropriate and related nutritional composition.The invention have the advantage that inventive formulation kidney warming and yang invigorating, lower warm uterus, invigorating qi and benefiting blood, Sheehan syndrome can be treated, improve body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, the merit of resisting fatigue.
Description
Technical field
The present invention relates to a kind of nutrient formulation nano-particle preventing and treating Sheehan syndrome, in particular, relate to one
The nutrient formulation nano-particle planting preventing and treating Sheehan syndrome and preparation method thereof technical field.
Background technology
Sheehan syndrome is adenohypophysial hormone hyposecretion caused by Different types of etiopathogenises, secondary gonad, thyroid, adrenal gland's skin
The clinical syndrome that matter hypofunction is presented.Typical performance is: puerperal after postpartum hemorrhage is suffered a shock, long-term weak weak,
It is without galactopoiesis the earliest, then secondary amenorrhea, even if menstruation recovery, the most rare, infertility.Hyposexuality, vagina is done
Dry, dyspareunia.Pubes, axillary trichomadesis, hair, eyebrow are sparse, breast, aedoeatrophia, and spirit is indifferent, drowsiness, do not like work
Dynamic, bradykinesia, fear of cold, lossless, xerosis cutis is coarse, poor appetite lack of appetite, constipation, body temperature is on the low side, pulse is slow, blood pressure reduction,
Pale complexion, anemia.Majority has edema, weight loss, and minority is become thin cachexia.
The traditional Chinese medical science thinks that Sheehan syndrome is by kidney yang virtual loss, lower unit deficiency, trauma punching times, QI and blood deficiency, kidney qi loss, born of the same parents
Merit is poor, causes long-term weak weak, is without galactopoiesis the earliest, and even if then secondary amenorrhea is menstruation recovery, the most rare,
The symptoms such as infertility；By kidney warming and yang invigorating, lower warm uterus, invigorating qi and benefiting blood, Sheehan syndrome can be treated.
For threpsology's angle, treatment Sheehan syndrome is in addition to taking regular Therapeutic Method and treating, also
It is noted that Diet Therapy, the nutrient that supply is sufficient, reasonably combined dietary structure.The present invention combines dietetic nutrition regulation just
Make a kind of health food granule having and supplementing the nutrients and assist treatment dual-use function with Chinese medicine formula, improve human body simultaneously and exempt from
Epidemic disease power, defying age, eliminating toxin and beautifying the skin, nourishing taste, drop three-hypers, prevent and treat diabetes and anti-cancer, the function of the aspect such as anticancer.
Summary of the invention
The present invention is directed to the deficiency of existing product, and provide one to have extra-nutrition, auxiliary treatment, improve self increase
The wriggling of the intestines and stomach, anti-curing the disease strengthens a kind of nutrient formulation nanometer preventing and treating Sheehan syndrome of the advantages such as body immunity simultaneously
Granule.
A kind of nutrient formulation nano-particle preventing and treating Sheehan syndrome, described nutrient formulation nano-particle is by following former
Material: Rhizoma Steudnerae Henryanae, rice, Semen setariae, corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum, aminoacid, the concentrated liquid of tradition Chinese medicine, vitamin are processed into；
Described nutrient formulation nanoparticle raw materials according to weight is: Rhizoma Steudnerae Henryanae 5-10 part, rice 1-5 part, Semen setariae 1-15 part,
Corn starch 5-10 part, fructus zizaniae caduciflorae 1-10 part, Semen Sesami Nigrum 1-10 part, aminoacid 0.1-0.5 part, the concentrated liquid of tradition Chinese medicine 2-5 part, vitamin
0.1-0.5 part；
The prescription of the concentrated liquid of tradition Chinese medicine in described nutrient formulation nano-particle according to weight is: Herba Cistanches 5-10 part, Chinese holly
Fructus Lycii 10-15 part, Radix Glycyrrhizae 10-15 part, Fructus Ligustri Lucidi 10-15 part, Cortex Eucommiae 6-15 part, Herba Cynomorii 5-10 part, Semen Cuscutae 5-10 part, Rhizoma Chuanxiong
10-15 part, Radix Astragali 10-16 part, Carapax Trionycis 10-16 part, Herba Epimedii 10-16 part, Air Bladder pseudosciaenae seu Acipenser 1-10 part, new fresh Herba Dendrobii 10-20 part, Fructus Vitis viniferae
10-20 part, Mel, water are appropriate.
Described amino acid whose raw material according to weight is: isoleucine 0.01-0.08 part, tyrosine 0.01-0.05
Part, phenylalanine 0.01-0.04 part, lysine 0.01-0.03 part, arginine 0.01-0.05 part, histidine 0.01-0.07 part,
Tryptophan 0.01-0.06 part, citrulline 0.01-0.05 part, ornithine 0.01-0.05 part, L-Leu 0.01 part, the different bright ammonia of L-
Acid 0.01 part, Valine 0.01 part；
Vitamin is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, vitamin
B2, vitamin B6, vitamin B12, vitamin B e, vitamin B u, nicotinic acid, folic acid, pantothenic acid, choline, biotin one therein,
Several or all mix；Maintain healthy institute required by adding to supplement.
The invention also discloses a kind of nutrient formulation nano-particle preventing and treating Sheehan syndrome and preparation processing method, bag
Include following steps；
A, new fresh Herba Dendrobii and Fructus Vitis viniferae are cleaned up, the fresh bar of screening high-quality Herba Dendrobii and Fructus Vitis viniferae, dry standby；
B, new fresh Herba Dendrobii is put into rotating centrifugal juice extractor and carry out Herba Dendrobii juice and separate with fiber stand-by；Again Fructus Vitis viniferae is put into and blow
In wind continuous way quick-freezing plant, by temperature be-40～the air of-30 DEG C makes the surface of Fructus Vitis viniferae tie according to the speed of 3～6m/s
Ice, then carry out Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae detached job；By Semen Vitis viniferae through vacuum outgas, then use CO2 shooting flow
Body extracts, and the condition of CO2 supercritical fluid extraction is: extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min,
Isolated Oleum Vitis viniferae is standby；
C, Herba Dendrobii juice and Fructus Vitis viniferae meat are put into mixing drum Matrix Solution I；
D, in hermetically sealed can add be equivalent to dendrobium fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the steaming of 5-10 times of weight
Distilled water, stirring is smashed to 100 mesh, is preserved 24h, sterilizing at 37.5 DEG C～38.9 DEG C lower seals of temperature, filter, put into unglazed sealing
Tank, keeps the temperature in hermetically sealed can, at the alphalise starch adding the 0.2%-0.5% being equivalent to dendrobium fiber and Pericarpium Vitis viniferae gross weight
Enzyme and the mixing enzyme preparation of protease；Enzymolysis 60 minutes under the conditions of pH6.5；After feed liquid after enzymolysis filters, filtrate concentrates and removes egg
After white, alcohol is washed, filtering residue deionized water wash；Feed liquid after enzymolysis is homogenizing under the supertension of 80～140MPa, and centrifugation is removed
Insoluble matter, obtains Matrix Solution II；
E, Fructus Ligustri Lucidi, the Cortex Eucommiae, Semen Cuscutae are placed in the distilled water of 40-50 DEG C, soak 20-30min minute, be heated to 100
DEG C, holding pressure is at the micro-15min that boils of 0.2MPa, then is filtered by above-mentioned solution；Filtering solution heats dense under the conditions of 0.05MPa
Contracting；By filtering solution but to less than 50 DEG C, filtering solution is pumped into the Alcohol-settling tank containing the ethanol that mass content is 85%, 30 points
Zhong Hou, is filtered alcohol deposit fluid by 0.3um filter, and alcohol deposit fluid obtained above heats under the conditions of 0.04MPa receipts alcohol,
Chinese medicine extraction liquid a；
The Radix Astragali, Carapax Trionycis, Herba Cynomorii mix and blend are put into super micron mill, and super micron mill heating keeps temperature 80 degree 5-6 minute,
Carry out micronizing and obtain the ultra micro mixing fine powders of 300-400 mesh；
Take Herba Cistanches, Fructus Lycii, Radix Glycyrrhizae, Rhizoma Chuanxiong, Herba Epimedii, Air Bladder pseudosciaenae seu Acipenser, after mix homogeneously adds 30-60 DEG C of warm water soaking 10 minutes,
Put into reach in freezer ,-10～-20 DEG C freezing 10-20 minute, form freezing medicine block, by freezing medicine block and ultra micro mixing fine powders
Boiling is extracted 3 times, adds 2 times amount water for the first time, and temperature keeps 100-120 DEG C, carries out infusion 20 minutes；Second time adds 4 times
Amount water, temperature keeps 80-100 DEG C, carries out infusion 10 minutes；Third time adds 2 times amount water, and temperature keeps 120-150 DEG C, endures
Boiling 30 minutes, filter, insulation is concentrated into the 1/2 of original volume, adds Chinese medicine extraction liquid a, obtains Matrix Solution III standby；
F, by Matrix Solution I, Matrix Solution II, Matrix Solution III hybrid filtering concentrate add Oleum Vitis viniferae obtain traditional Chinese drug inspissation
Liquid；
G, the nutritional labelings such as Rhizoma Steudnerae Henryanae, rice, Semen setariae, corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum are put into super micron mill, obtain granule thick
Powder, and within 15 minutes, carry out sterilizing by 100 DEG C of microwave heatings, again granule coarse powder is put into nanometered disposal equipment and carry out pure physics
Pulverization process is crushed to 1-100nm；Granule coarse powder adds aminoacid, vitamin, the concentrated liquid of tradition Chinese medicine and adjuvant and stirs and carry out
Wet granulation or one-step palletizing preparing granular.
Further: described adjuvant is selected from dextrin, beta-schardinger dextrin-, soluble starch, microcrystalline Cellulose, magnesium carbonate or calcium carbonate
In any one.
Further: the step of the wet granulation in described step G is as follows: in mixer-granulator, to add binding agent system
Wet granular, paddle rotating speed 70～150 revs/min, fly cutter rotating speed 200～800 revs/min, run 10～30 minutes, by wet
Grain is placed in boiling drier, inlet temperature 45～85 DEG C, is dried 5～30 minutes, obtains granule, control pellet moisture 4.0%～
9.0%；
Further: the step of the one-step palletizing in described step G is as follows: control particle temperature, at 50 ± 5 DEG C, is dried, moisture control
System is 4.0%～9.0%.
Rhizoma Steudnerae Henryanae: its rich in proteins, starch, pectin, cellulose, aminoacid, vitamin and several mineral materials, simultaneously the richest
Containing selenium element and anthocyanidin, the special health care of the nutritious tool of Rhizoma Steudnerae Henryanae, gal4 amino acid therein is all easily by human body
Digest and absorb；Wherein rich in vitamin A can improve the mucomembranous epithelial cell of vision and skin, vitamin C can
Making collagen protein normally synthesize, prevent and treat scorbutic generation, anthocyanidin is natural potent free radical scavenger, has common Radix Ipomoeae
Nutritional labeling outside, also rich in selenium element, ferrum element and anthocyanidin.
Semen setariae: Semen setariae is also known as Semen setariae, is standing grain ancient times, is the product after millet is shelled.In addition to abundant irony, Semen setariae
Also there is protein, compound vitamin B, calcareous, potassium, cellulose etc..Semen setariae is contained within the multiple functional factor useful to property, energy
Tonifying YANG, YIN nourishing, aristogenesis.
The rice traditional Chinese medical science thinks that nature and flavor are sweet flat, has invigorating the spleen and replenishing QI, strengthening the spleen and nourishing the stomach, the strong will of benefit essence and the five internal organs, promoting blood circulation, audition improvement
Improving eyesight, be only tired of, quench the thirst, effect of antidiarrheal, it is believed that polyphagia can make us " kept fit color ".
Corn starch is universally acknowledged " gold crop ", and its fat, P elements, the content of vitamin B2 occupy cereal
First of；Containing linoleic acid and vitamin E in Semen Maydis flour, cholesterol in human body level can be made to reduce, thus reduce arteriosclerosis
Occur；Calcic in Semen Maydis flour, irony are more, can prevent hypertension, coronary heart disease；Modern medicine study shows, has rich in Semen Maydis flour
Rich glutathion, this is a kind of anticancer factor, can combine with multiple external chemical carcinogen so that it is lose in human body
Go toxicity, then excreted by digestive tract.Containing substantial amounts of lysine in the Semen Maydis flour of corase grind, tumor growth can be suppressed.
Fructus zizaniae caduciflorae is a kind of medicine, the rice of food dual-purpose, belongs to Oryza glutinosa class.Fructus zizaniae caduciflorae .5% Han protein 12, crude fat 2.7-3.8%,
Carbohydrate 75-84%, coarse ash 1.7-2%.The vitamin C that lacked containing rice, chlorophyll, anthocyanidin, carotene
And the special composition such as cardiotonic glycoside, nutritious, there is good tonic effect.
Semen Sesami Nigrum medicine-food two-purpose, has effects such as " invigorating the liver and kidney, grow the five internal organs, benefiting essence-blood, and intestine moistening is dry ", on the one hand is because containing
There are high quality protein and abundant mineral, are on the other hand because containing abundant unsaturated fatty acid, vitamin E and preciousness
Sesamin and melanin.
Vitamin is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, dimension
Raw element B2, vitamin B6, vitamin B12, vitamin B e, vitamin B u, nicotinic acid, folic acid, pantothenic acid, choline, biotin are therein
A kind of, several or all mix；Maintain healthy institute required by adding to supplement.
Amino acid whose raw material according to weight is: isoleucine 0.01-0.08 part, tyrosine 0.01-0.05 part, benzene
Alanine 0.01-0.04 part, lysine 0.01-0.03 part, arginine 0.01-0.05 part, histidine 0.01-0.07 part, color ammonia
Acid 0.01-0.06 part, citrulline 0.01-0.05 part, ornithine 0.01-0.05 part, L-Leu 0.01 part, ILE
0.01 part, Valine 0.01 part；
Herba Cistanches, for impotence due to deficiency of the kidney, seminal emission premature ejaculation and chills and pain of the waist and kness, muscles and bones convulsion is weak.
Fructus Lycii, sweet, flat, for syndrome of yin deficiency of liver and kidney, sweet flat matter is moistened, flat invigorating the liver and kidney, has strengthening by means of tonics effect, and all Liver and kidney are cloudy
Empty all cards all can be applied.
Radix Glycyrrhizae, and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.
Fructus Ligustri Lucidi, sweet, bitter, cold.Returning liver, kidney channel, liver and kidney tonifying, improving eyesight, by the main lung of kidney, clearind deficient heat.
The Cortex Eucommiae, invigorating the liver and kidney, bone and muscle strengthening
Herba Cynomorii can treat sexual impotence, hematuria, blood depletion, constipation and soreness of the waist and knees with the kidney invigorating intestine moistening.
Semen Cuscutae, property is sweet, warm, returns kidney, liver, warp, has nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, effect of antidiarrheal.
Rhizoma Chuanxiong, acrid in the mouth, temperature, enter liver, spleen, three burnt three warps, activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.
The Radix Astragali, returns lung, spleen, liver, kidney channel.Enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and
Wide antibacterial action.
Carapax Trionycis, salty, flat.Enter liver,spleen,kidney warp.Nourishing YIN for suppressing the hyperactive YANG, eliminating stagnation disappears painful abdominal mass.For deficiency of kidney yin.
Herba Epimedii, abnormal smells from the patient is pungent, warm, nontoxic.Warm in nature do not tremble with fear, can benefit vital essence.
Air Bladder pseudosciaenae seu Acipenser, sweet, flat, nontoxic.Sweet in the mouth, temperature.Enter kidney.The kidney invigorating and essence nourishing, nourishes muscle arteries and veins, hemostasis, dissipating blood stasis, detumescence, controls kidney
Empty spermatorrhea.
Fructus Vitis viniferae nutritive value is the highest, containing mineral calcium, potassium, phosphorus, ferrum and multivitamin B1, vitamin in Fructus Vitis viniferae
B2, vitamin B6, vitamin C and Citrin etc., possibly together with the aminoacid of multiple needed by human body, multiple fruit acid contributes to digestion,
Suitably eating a little Fructus Vitis viniferae more, can be good for Pi stomach function regulating, to neurasthenia, overfatigue is of great advantage and has.
The natural tradition medicinal and edible Chinese medicine above with multiple health care is share, kidney warming and yang invigorating, lower warm uterus, benefit
Gas benefit blood, can treat Sheehan syndrome, improves body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, the merit of resisting fatigue.
The proportioning of each component is screened by great many of experiments, scientific and reasonable；And whole preparation technology is rationally and extract drugs rate efficiency is high,
The effective ingredient in raw material can be retained well, do not bring any impurity, and sweet mouthfeel into, have no side effect.
The invention has the beneficial effects as follows:
1, the nutrient formulation nano-particle of the present invention, has promoting the production of body fluid to quench thirst, gastric acid secretion, helps digest, and health body-building has
Calm nerves is weak, lessens fatigue, containing various trace elements such as calcium, ferrum, zinc, selenium, sodium etc., to improving body immunity, resisting
Aging, eliminating toxin and beautifying the skin, nourishing taste, three-hypers drops, to prevent and treat diabetes and anti-cancer, the aspect such as anticancer the most powerful, regulation human body is raw
Reason function.
2, the present invention is rich in anthocyanidin, it is possible to protection human body is from the damage of free radical, it is possible to strengthens blood vessel elasticity, relax
Blood vessel, increases systemic blood circulation, has certain blood pressure reduction effect；Immune system ability can be strengthened, there is strong anti-oxidation, resist
Suddenly change, alleviate the function such as hepatosis, protection cardiovascular；
3, add Chinese herbal medicine and there is kidney warming and yang invigorating, lower warm uterus, invigorating qi and benefiting blood, Sheehan syndrome can be treated, improve human body and exempt from
The functions such as epidemic disease power, defying age, eliminating toxin and beautifying the skin, nourishing taste, resisting fatigue.
4, the products taste that the production technology of the present invention and preparation method draw is sour-sweet tasty and refreshing, rich in dendrobium polysaccharide, has
The highest health care and medical value, life-time service can with YIN nourishing skin care, change skin colour, defying age, life lengthening, and
Carry easy to use, improve self and increase the wriggling of the intestines and stomach, cure the disease and strengthen body immunity simultaneously.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, in order to those skilled in the art knows more about
The present invention, but and it is not so limited the present invention.
Embodiment 1
A kind of nutrient formulation nano-particle preventing and treating Sheehan syndrome, described nutrient formulation nano-particle is by following raw material: purple
Potato, rice, Semen setariae, corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum, aminoacid, the concentrated liquid of tradition Chinese medicine, vitamin and water are processed in right amount；
Described nutrient formulation nanoparticle raw materials according to weight is: Rhizoma Steudnerae Henryanae 8 parts, 2 parts of rice, Semen setariae 5 parts, corn starch
8 parts, fructus zizaniae caduciflorae 8 parts, Semen Sesami Nigrum 8 parts, 0.1 part of aminoacid, the concentrated liquid of tradition Chinese medicine 5 parts, vitamin 0.1 part；
The prescription of described the concentrated liquid of tradition Chinese medicine according to weight is: Herba Cistanches 8 parts, Fructus Lycii 12 parts, 12 parts of Radix Glycyrrhizae, Fructus Ligustri Lucidi
12 parts, the Cortex Eucommiae 12 parts, Herba Cynomorii 8 parts, Semen Cuscutae 10 parts, Rhizoma Chuanxiong 10 parts, the Radix Astragali 15 parts, Carapax Trionycis 15 parts, Herba Epimedii 15 parts, Air Bladder pseudosciaenae seu Acipenser 10
Part, new fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, Mel, water are appropriate.
Described amino acid whose raw material according to weight is: isoleucine 0.02 part, 0.03 part of tyrosine, phenylalanine
0.01 part, lysine 0.01 part, arginine 0.01 part, histidine 0.01 part, tryptophan 0.01 part, citrulline 0.01 part, bird ammonia
Acid 0.01 part, L-Leu 0.01 part, ILE 0.01 part, Valine 0.01 part；
Vitamin is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, vitamin
B2, vitamin B6, vitamin B12, vitamin B e, vitamin B u, nicotinic acid, folic acid, pantothenic acid, choline, whole mixing of biotin
And weight portion is identical.
The preparation processing method of a kind of nutrient formulation nano-particle preventing and treating Sheehan syndrome, comprises the following steps；
A, new fresh Herba Dendrobii and Fructus Vitis viniferae are cleaned up, the fresh bar of screening high-quality Herba Dendrobii and Fructus Vitis viniferae, dry standby；
B, new fresh Herba Dendrobii is put into rotating centrifugal juice extractor and carry out Herba Dendrobii juice and separate with fiber stand-by；Again Fructus Vitis viniferae is put into and blow
In wind continuous way quick-freezing plant, by temperature be-40～the air of-30 DEG C makes the surface of Fructus Vitis viniferae tie according to the speed of 3～6m/s
Ice, then carry out Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae detached job；By Semen Vitis viniferae through vacuum outgas, then use CO2 shooting flow
Body extracts, and the condition of CO2 supercritical fluid extraction is: extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min,
Isolated Oleum Vitis viniferae is standby；
C, Herba Dendrobii juice and Fructus Vitis viniferae meat are put into mixing drum Matrix Solution I；
D, in hermetically sealed can add be equivalent to dendrobium fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the steaming of 5-10 times of weight
Distilled water, stirring is smashed to 100 mesh, is preserved 24h, sterilizing at 37.5 DEG C～38.9 DEG C lower seals of temperature, filter, put into unglazed sealing
Tank, keeps the temperature in hermetically sealed can, at the alphalise starch adding the 0.2%-0.5% being equivalent to dendrobium fiber and Pericarpium Vitis viniferae gross weight
Enzyme and the mixing enzyme preparation of protease；Enzymolysis 60 minutes under the conditions of pH6.5；After feed liquid after enzymolysis filters, filtrate concentrates and removes egg
After white, alcohol is washed, filtering residue deionized water wash；Feed liquid after enzymolysis is homogenizing under the supertension of 80～140MPa, and centrifugation is removed
Insoluble matter, obtains Matrix Solution II；Rich in anthocyanidin in Pericarpium Vitis viniferae, it is possible to protection human body is from the damage of free radical, it is possible to strengthen
Blood vessel elasticity, lax blood vessel, increase systemic blood circulation, have certain blood pressure reduction effect；Immune system ability can be strengthened, tool
Have strong anti-oxidation, mutation, alleviate hepatosis, protection function, Pericarpium Vitis viniferae and the Herba Dendrobii fresh bar fiber such as cardiovascular together with stir
Mix to smash and mention anthocyanidin through hydromel, while farthest extracting anthocyanidin, can protect the quality of anthocyanidin.Will
Water soluble dietary fiber adds Matrix Solution and obtains Matrix Solution II, can increase effect of the wriggling of the intestines and stomach, it is ensured that metabolic waste
Normally excrete；Adsorbing various metabolic waste, be allowed to normally excrete, the comprehensive utilization value improving Herba Dendrobii improves simultaneously
The human body absorption to Chinese medicine ingredients.
E, Fructus Ligustri Lucidi, the Cortex Eucommiae, Semen Cuscutae are placed in the distilled water of 40-50 DEG C, soak 20-30min minute, be heated to
100 DEG C, holding pressure is at the micro-15min that boils of 0.2MPa, then is filtered by above-mentioned solution；Filtering solution heats under the conditions of 0.05MPa
Concentrate；By filtering solution but to less than 50 DEG C, filtering solution is pumped into the Alcohol-settling tank containing the ethanol that mass content is 85%, 30
After minute, alcohol deposit fluid is filtered by 0.3um filter, alcohol deposit fluid obtained above is heated under the conditions of 0.04MPa receipts alcohol,
Obtain Chinese medicine extraction liquid a；
The Radix Astragali, Carapax Trionycis, Herba Cynomorii mix and blend are put into super micron mill, and super micron mill heating keeps temperature 80 degree 5-6 minute,
Carry out micronizing and obtain the ultra micro mixing fine powders of 300-400 mesh；
Take Herba Cistanches, Fructus Lycii, Radix Glycyrrhizae, Rhizoma Chuanxiong, Herba Epimedii, Air Bladder pseudosciaenae seu Acipenser, after mix homogeneously adds 30-60 DEG C of warm water soaking 10 minutes,
Put into reach in freezer ,-10～-20 DEG C freezing 10-20 minute, form freezing medicine block, by freezing medicine block and ultra micro mixing fine powders
Boiling is extracted 3 times, adds 2 times amount water for the first time, and temperature keeps 100-120 DEG C, carries out infusion 20 minutes；Second time adds 4 times
Amount water, temperature keeps 80-100 DEG C, carries out infusion 10 minutes；Third time adds 2 times amount water, and temperature keeps 120-150 DEG C, endures
Boiling 30 minutes, filter, insulation is concentrated into the 1/2 of original volume, adds Chinese medicine extraction liquid a, obtains Matrix Solution III standby；
F, by Matrix Solution I, Matrix Solution II, Matrix Solution III hybrid filtering concentrate add Oleum Vitis viniferae obtain traditional Chinese drug inspissation
Liquid；
G, Rhizoma Steudnerae Henryanae, rice, Semen setariae, corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum are put into super micron mill, obtain granule coarse powder, and pass through
100 DEG C of microwave heatings carry out sterilizing for 15 minutes, granule coarse powder is put into nanometered disposal equipment again and carries out pure physical pulverization process
It is crushed to 1-100nm；Granule coarse powder adds aminoacid, vitamin, the concentrated liquid of tradition Chinese medicine and adjuvant and stirs and carry out wet method system
Grain, paddle rotating speed 70～150 revs/min, fly cutter rotating speed 200～800 revs/min, run 10～30 minutes, put by wet granular
In boiling drier, inlet temperature 45～85 DEG C, it is dried 5～30 minutes, obtains granule, control pellet moisture 4.0%～9.0%.
Comparative example 2
A kind of nutrient formulation nano-particle preventing and treating Sheehan syndrome, processing method and other nutritional labelings are with embodiment 1, institute
The prescription stating the concentrated liquid of tradition Chinese medicine according to weight is: Herba Cistanches 8 parts, Fructus Lycii 12 parts, 12 parts of Radix Glycyrrhizae, Fructus Ligustri Lucidi 12 parts,
The Cortex Eucommiae 12 parts, Herba Cynomorii 8 parts, Semen Cuscutae 10 parts, Rhizoma Chuanxiong 10 parts, the Radix Astragali 15 parts, Carapax Trionycis 15 parts, Herba Epimedii 15 parts, new fresh Herba Dendrobii 15
Part, Fructus Vitis viniferae 15 parts, Mel, water are appropriate.Compare without Air Bladder pseudosciaenae seu Acipenser composition with embodiment 1.
Comparative example 3
A kind of nutrient formulation nano-particle preventing and treating Sheehan syndrome, other nutritional labelings with embodiment 1, the concentrated liquid of tradition Chinese medicine
Prescription according to weight is: Herba Cistanches 8 parts, Fructus Lycii 12 parts, 12 parts of Radix Glycyrrhizae, Fructus Ligustri Lucidi 12 parts, the Cortex Eucommiae 12 parts, Herba Cynomorii 8
Part, Semen Cuscutae 10 parts, Rhizoma Chuanxiong 10 parts, the Radix Astragali 15 parts, Carapax Trionycis 15 parts, Herba Epimedii 15 parts, 10 parts of Air Bladder pseudosciaenae seu Acipenser..Compare not with embodiment 1
Containing new fresh Herba Dendrobii, Fructus Vitis viniferae, honey component and the Matrix Solution I being processed into, Matrix Solution II.Preparation for processing is: implement
E and G of example 1 procedure of processing.
Comparative example 4
A kind of nutrient formulation nano-particle preventing and treating Sheehan syndrome, compares without Rhizoma Steudnerae Henryanae, rice, Semen setariae, jade with embodiment 1
The nutritional labelings such as rice starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum；Other are the most same as in Example 1.
Comparative example 5
A kind of nutrient formulation nano-particle preventing and treating Sheehan syndrome, compares without aminoacid, vitamin etc. micro-with embodiment 1
Secondary element；Other are the most same as in Example 1.
Comparative example 6
A kind of nutrient formulation nano-particle preventing and treating Sheehan syndrome, compares with embodiment 1: without Rhizoma Steudnerae Henryanae, rice, Semen setariae,
Nutritional labeling and the trace element such as aminoacid, vitamin such as corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum；Other are the most same as in Example 1.
Comparative example 7
A kind of nutrient formulation nano-particle preventing and treating Sheehan syndrome, compares with embodiment 1: except for the difference that, produces Chinese medicine dense
Contracting liquid, by medical material add water direct boiling method prepare.
Clinical experiment divides three parts:
(1) animal acute toxicity and chronic toxicity experiment:
1, animal acute toxicity test
Medicine: the embodiment of the present invention 1 and remaining comparative example's gained nutritive powder.
Experimental animal: regular grade NIH mice, body weight 18g ± 2g, male and female half and half.
Method and result:
By each for nutritional granular 50g, adding water, the nutritional granular powder made is stuck with paste.Experiment mice is randomly divided into 7 groups of male and female half and half,
7 kinds of nutritional granular powder of feeding are stuck with paste respectively, volume 1ml/10g body weight, and close observation 8 hours is also noted down, and continue to observe 7 days；7
In it, mice is without death, and behavior is active, and food ration is as usual, and hair color light is without loose dirt, without fainting from fear addicted to saliva, eye, mouth, nose, ear and
Crissum secretions without exception, without the rotten toe that docks.Respectively from 7 groups select 2 execution, finding of naked eye: the heart, liver, lung, gastric and
The important organs such as thymus, no abnormality seen changes, shows that two kinds of these nutritive powders are all without acute toxicity.
2, long-term toxicity test for animals
Medicine: the embodiment of the present invention 1 and remaining comparative example's gained nutritional granular nutritional granular powder made that adds water is stuck with paste.
Animal: regular grade SD rat, body weight 200g ± 10g, male and female half and half.
Method and result:
The configuration that 7 kinds of nutritional granular powder are stuck with paste: be divided into high, medium and low three dosage groups, respectively the 200 of edible for patients amount, 100,
50g；Experimental mouse is randomly divided into 7 groups, and the nutritional granular powder that feeding modulates continuously respectively is stuck with paste, and continuous feeding 40 days is observed dynamic
Thing general toxic reaction and the order of severity, place after death by rule of operation check each position, and carry out hematology, ALT, BUN and
The pathological examination of the main organs such as the heart, liver, spleen, lung, kidney, stomach；
Through long-term feeding, all there is not toxic reaction in two groups of rats.Growth promoter is good.Macroscopic appearance and main organs have no
Abnormal.Peripheral hemogram and Serum ALT, BUN compare with matched group without pathologic change.The pathological replacement heart, liver, spleen, lung, kidney, stomach
Deng the most significant change, it is understood that through proved by pathology, 7 kinds of nutritional granular powder are stuck with paste animal without chronic toxicity table
Existing.
By two above toxicity test, it was demonstrated that the nutritional granular that the present invention is made by embodiment 1 and comparative example is
Safety, have no side effect, can be used to clinical patients is carried out clinical trial.
3, embodiment of the present invention using effect investigation:
(1) investigation method:
1. crowd is used: general population
2. the time is used: 90 days
3. number of users: 100 people
4. using method: the most soaked 500 mL
5. index: nape pain, upper myasthenia of limbs, finger is numb, lower limb are weak, difficulty in walking, dizziness, Nausea and vomiting, even
Blurred vision, tachycardia and dysphagia, the transference cure such as tired, and mouthfeel is the most sour-sweet for effective；Above-mentioned clinic after drinking
Remission, and mouthfeel is the most sour-sweet, is designated as effectively.It is invalid to be then designated as without obvious comfort after drinking.
(2) survey result
Survey result is shown in Table 1.
Table 1 each embodiment using effect application form
Conclusion
Be can be seen that by the data of comparative example 2, the ratio of invalid number is compared with embodiment 1, adds 8%, shows Air Bladder pseudosciaenae seu Acipenser
In Chinese medicine formula, serve priming return through, the function heightened the effect of a treatment, improve the human body assimilation effect to medicine；Bolus for invigorating kidney and improving,
Kidney has the function that Tibetan, main store essential substances, main growth promoter and reproduction are taken the photograph by main department, the liquefaction of main water is thanked.Normal renal function then vital essence fills,
The all dirty negative and positive of whole body are the most prosperous；Conversely, as the impact or worn with age of various paathogenic factors, renal function can be caused not normal.Due to fish
Fish glue is a kind of rich sticking material, containing nutritional labelings such as profuse protein, vitamin, mineral, so, fish bubble tool
There are the kidney invigorating waist knee joint empty, strong, yin nourishing benefit smart and the effect of moist skin care.For having a delicate constitution, Kidney-Yin loss, psychentonia, fatigue
Excessive personage is the most suitable.
The data compared with embodiment 1 by comparative example 3 can be seen that, without new fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, honeybee
Honey composition and the Matrix Solution I being processed into, Matrix Solution II；The ratio of invalid number is compared with embodiment 1, adds 7
Times；And the average time of obvious effective rate, compare many 3 days than embodiment 1 and (i.e. felt effective, the average sky of clinical symptom disappearance
How count 3 days；This shows that the preparation for processing of the present invention makes the concentrated liquid of tradition Chinese medicine prescription and water soluble dietary fiber and Semen Vitis viniferae
Creating the most collaborative pharmacological action between the compositions such as oil, water soluble dietary fiber increases effect of the wriggling of the intestines and stomach and promotes people
The body absorption to ingredient, it is ensured that metabolic waste normally excretes, the anthocyanidin additionally contained in Pericarpium Vitis viniferae, white hellebore
Alcohol, has strong anti-oxidation, mutation, alleviates the function such as hepatosis, protection cardiovascular, strengthen immune system ability；In with
Medicine is associated with raising assimilation effect, improves the mouthfeel of Chinese medicine simultaneously, through the configuration and at utmost ingredient meticulously of the present invention
Extraction, traditional Chinese drug inspissation formula of liquid of the present invention and preparation method occur in that beat all technique effect.
Compared with embodiment 1 by the data of comparative example 4 and can be seen that, without Rhizoma Steudnerae Henryanae, rice, Semen setariae, corn starch,
The nutritional labeling such as fructus zizaniae caduciflorae, Semen Sesami Nigrum, the ratio of invalid number is compared with embodiment 1, adds 10 times, and the number of obvious effective rate
Also reduced, show the nutritional labeling the concentrated liquid of tradition Chinese medicines such as the Rhizoma Steudnerae Henryanae of the present invention, rice, Semen setariae, corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum
Drug effect between create mutually collaborative pharmacological action, the nutrient that supply human body is sufficient, dietary structure is reasonably combined,
Nutritional labeling supplements the necessary energy of human body, reaches balanced nutritious, promotes the health absorption to medicine.
Compared with embodiment 1 by comparative example 5, the trace element such as aminoacid, vitamin；Supplementary needed by human body is wanted
Highly important effect is had during nutrient and trace element regulation physiological function, catalysis metabolic adsorption medicine.
The data compared with embodiment 1 by comparative example 6 can be seen that, without Rhizoma Steudnerae Henryanae, rice, Semen setariae, corn starch,
The nutritional labeling such as fructus zizaniae caduciflorae, Semen Sesami Nigrum and the trace element such as aminoacid, vitamin；Inefficiency number nearly 15 times and effective percentage number
Also nearly 20% is declined；And the average time of obvious effective rate, compare many 10 days than embodiment 1 and (i.e. felt effective people, clinical condition
The average time that shape disappears is many 10 days；Illustrate nutritional labeling and trace element human body medicine absorb during played and
Its important synergism, greatly promotes human body and recovers medicine and the absorption of nutrition, quickening human body.
The data compared with embodiment 1 by comparative example 7 can be seen that, medical material adds water direct boiling method and the present invention
Chinese medicine preparation method compare, the preparation method of the present invention, the extraction of drug effect is far longer than traditional adding water and directly boils
Method, the extraction degree of active ingredient has had huge raising.
In sum, the preparation processing of a kind of nutrient formulation nano-particle preventing and treating Sheehan syndrome that the present invention provides
Method, the pharmacological action that nutritional labeling is mutually worked in coordination with, the nutrient that supply human body is sufficient, dietary structure is reasonably combined, nutrition
Composition supplements the necessary energy of human body, reaches balanced nutritious, promotes the health absorption to medicine, and all raw materials are all from medicine food two
With natural plants, have no side effect.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For Yuan, under the premise without departing from the principles of the invention, it is also possible to make some improvements and modifications, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (6)
1. the nutrient formulation nano-particle preventing and treating Sheehan syndrome, it is characterised in that described nutrient formulation nano-particle
By following raw material: Rhizoma Steudnerae Henryanae, rice, Semen setariae, corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum, aminoacid, the concentrated liquid of tradition Chinese medicine, vitamin and water are suitable
Amount is processed into；
Described nutrient formulation nanoparticle raw materials according to weight is: Rhizoma Steudnerae Henryanae 5-10 part, rice 1-5 part, Semen setariae 1-15 part,
Corn starch 5-10 part, fructus zizaniae caduciflorae 1-10 part, Semen Sesami Nigrum 1-10 part, aminoacid 0.1-0.5 part, the concentrated liquid of tradition Chinese medicine 2-5 part, vitamin
0.1-0.5 part；
The prescription of described the concentrated liquid of tradition Chinese medicine according to weight is: Herba Cistanches 5-10 part, Fructus Lycii 10-15 part, Radix Glycyrrhizae 10-15
Part, Fructus Ligustri Lucidi 10-15 part, Cortex Eucommiae 6-15 part, Herba Cynomorii 5-10 part, Semen Cuscutae 5-10 part, Rhizoma Chuanxiong 10-15 part, Radix Astragali 10-16 part,
Carapax Trionycis 10-16 part, Herba Epimedii 10-16 part, Air Bladder pseudosciaenae seu Acipenser 1-10 part, new fresh Herba Dendrobii 10-20 part, Fructus Vitis viniferae 10-20 part, Mel, water are appropriate.
A kind of nutrient formulation nano-particle preventing and treating Sheehan syndrome the most according to claim 1, it is characterised in that institute
Stating amino acid whose raw material according to weight is: isoleucine 0.01-0.08 part, tyrosine 0.01-0.05 part, phenylalanine
0.01-0.04 part, lysine 0.01-0.03 part, arginine 0.01-0.05 part, histidine 0.01-0.07 part, tryptophan 0.01-
0.06 part, citrulline 0.01-0.05 part, ornithine 0.01-0.05 part, L-Leu 0.01 part, ILE 0.01 part, L-
Valine 0.01 part.
3. the preparation processing method of the nutrient formulation nano-particle preventing and treating Sheehan syndrome, it is characterised in that include with
Lower step；
A, new fresh Herba Dendrobii and Fructus Vitis viniferae are cleaned up, the fresh bar of screening high-quality Herba Dendrobii and Fructus Vitis viniferae, dry standby；
B, new fresh Herba Dendrobii is put into rotating centrifugal juice extractor and carry out Herba Dendrobii juice and separate with fiber stand-by；Again Fructus Vitis viniferae is put into and blow
In wind continuous way quick-freezing plant, by temperature be-40～the air of-30 DEG C makes the surface of Fructus Vitis viniferae tie according to the speed of 3～6m/s
Ice, then carry out Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae detached job；By Semen Vitis viniferae through vacuum outgas, then use CO2 shooting flow
Body extracts, and the condition of CO2 supercritical fluid extraction is: extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min,
Isolated Oleum Vitis viniferae is standby；
C, Herba Dendrobii juice and Fructus Vitis viniferae meat are put into mixing drum Matrix Solution I；
D, in hermetically sealed can add be equivalent to dendrobium fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the steaming of 5-10 times of weight
Distilled water, stirring is smashed to 100 mesh, is preserved 24h, sterilizing at 37.5 DEG C～38.9 DEG C lower seals of temperature, filter, put into unglazed sealing
Tank, keeps the temperature in hermetically sealed can, at the alphalise starch adding the 0.2%-0.5% being equivalent to dendrobium fiber and Pericarpium Vitis viniferae gross weight
Enzyme and the mixing enzyme preparation of protease；Enzymolysis 60 minutes under the conditions of pH6.5；After feed liquid after enzymolysis filters, filtrate concentrates and removes egg
After white, alcohol is washed, filtering residue deionized water wash；Feed liquid after enzymolysis is homogenizing under the supertension of 80～140MPa, and centrifugation is removed
Insoluble matter, obtains Matrix Solution II；
E, Fructus Ligustri Lucidi, the Cortex Eucommiae, Semen Cuscutae are placed in the distilled water of 40-50 DEG C, soak 20-30min minute, be heated to 100
DEG C, holding pressure is at the micro-15min that boils of 0.2MPa, then is filtered by above-mentioned solution；Filtering solution heats dense under the conditions of 0.05MPa
Contracting；By filtering solution but to less than 50 DEG C, filtering solution is pumped into the Alcohol-settling tank containing the ethanol that mass content is 85%, 30 points
Zhong Hou, is filtered alcohol deposit fluid by 0.3um filter, and alcohol deposit fluid obtained above heats under the conditions of 0.04MPa receipts alcohol,
Chinese medicine extraction liquid a；
The Radix Astragali, Carapax Trionycis, Herba Cynomorii mix and blend are put into super micron mill, and super micron mill heating keeps temperature 80 degree 5-6 minute,
Carry out micronizing and obtain the ultra micro mixing fine powders of 300-400 mesh；
Taking Herba Cistanches, Fructus Lycii, Rhizoma Curculiginis, Radix Glycyrrhizae, Rhizoma Chuanxiong, Herba Epimedii, Air Bladder pseudosciaenae seu Acipenser, mix homogeneously adds 30-60 DEG C of warm water soaking 10 points
Zhong Hou, puts into reach in freezer ,-10～-20 DEG C freezing 10-20 minute, forms freezing medicine block, by freezing medicine block and ultra micro mixing
Fine powder boiling is extracted 3 times, adds 2 times amount water for the first time, and temperature keeps 100-120 DEG C, carries out infusion 20 minutes；Second time adds
4 times amount water, temperature keeps 80-100 DEG C, carries out infusion 10 minutes；Third time adds 2 times amount water, and temperature keeps 120-150 DEG C, enters
Row infusion 30 minutes, filters, and insulation is concentrated into the 1/2 of original volume, adds Chinese medicine extraction liquid a, obtains Matrix Solution III standby；
F, by Matrix Solution I, Matrix Solution II, Matrix Solution III hybrid filtering concentrate add Oleum Vitis viniferae obtain traditional Chinese drug inspissation
Liquid；
G, the nutritional labelings such as Rhizoma Steudnerae Henryanae, rice, Semen setariae, corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum are put into super micron mill, obtain granule thick
Powder, and within 15 minutes, carry out sterilizing by 100 DEG C of microwave heatings, again granule coarse powder is put into nanometered disposal equipment and carry out pure physics
Pulverization process is crushed to 1-100nm；Granule coarse powder adds aminoacid, vitamin, the concentrated liquid of tradition Chinese medicine and adjuvant and stirs and carry out
Wet granulation or one-step palletizing preparing granular.
The preparation processing side of a kind of nutrient formulation nano-particle preventing and treating Sheehan syndrome the most according to claim 3
Method, it is characterised in that described adjuvant is selected from dextrin, beta-schardinger dextrin-, soluble starch, microcrystalline Cellulose, magnesium carbonate or calcium carbonate
In any one.
The preparation processing side of a kind of nutrient formulation nano-particle preventing and treating Sheehan syndrome the most according to claim 3
Method, it is characterised in that the step of the wet granulation in described step G is as follows: add binding agent system in mixer-granulator
Wet granular, paddle rotating speed 70～150 revs/min, fly cutter rotating speed 200～800 revs/min, run 10～30 minutes, by wet
Grain is placed in boiling drier, inlet temperature 45～85 DEG C, is dried 5～30 minutes, obtains granule, control pellet moisture 4.0%～
9.0%。
The preparation processing side of a kind of nutrient formulation nano-particle preventing and treating Sheehan syndrome the most according to claim 3
Method, it is characterised in that the step of the one-step palletizing in described step G is as follows: control particle temperature, at 50 ± 5 DEG C, is dried, moisture
Control 4.0%～9.0%.
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