CN106135906A - Jilin Radix Ginseng oligopeptide purposes in the food or health food of preparation resisting fatigue - Google Patents
Jilin Radix Ginseng oligopeptide purposes in the food or health food of preparation resisting fatigue Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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Abstract
The invention discloses Jilin Radix Ginseng oligopeptide purposes in the food or health food of preparation resisting fatigue.Jilin Radix Ginseng oligopeptide is the mixture of the small molecule bioactive peptide utilizing biological enzymolysis technology to obtain from Jilin Radix Ginseng.Jilin Radix Ginseng oligopeptide easily absorbs, absorb fast and viscosity is low, directly can absorb without digestion at human body, bioavailability height.Present invention finds Jilin Radix Ginseng oligopeptide and can have significant antifatigue effect with the generation of delay fatigue and the elimination accelerated fatigue, can be used for preparing food or the health food of resisting fatigue, and provide a kind of new way for carrying out fatigue alleviating by diet.
Description
Technical field
The present invention relates to a kind of new application of Jilin Radix Ginseng oligopeptide, Jilin Radix Ginseng oligopeptide is at the food of preparation resisting fatigue specifically
Or the purposes in health food.
Background technology
Fatigue is that health is overworked, the most nervous, sleep insuffience time normal and important reaction, but be also a kind of heart
Reason or the non-specific performance of physiological barrier.Along with economic develops rapidly, rhythm of life accelerates, and working strength is big, diet is practised
The many reasons such as used bad, shortage motion exercise cause people's passive protective physical fitness to decline, it is easy to produce fatigue.Under prior art
Though the health product of some resisting fatigue have certain curative effect, but utilization rate is low, and adds chemicals more, and long-term taking may be right
Human body produces negative interaction, therefore prepares a kind of special diet containing safe and effective natural materials and prevents to show with fatigue alleviating
Obtain the most urgent.
Biologically active peptide refers to that the vital movement to living organism is useful or has the peptides of physiological action.Peptide is tied at molecule
It is in the centre position of amino acid and protein on structure, but it has the irreplaceable function of amino acid and protein.Oligopeptide,
It is also called active small molecular peptide, is typically made up of 10 or less than 10 aminoacid.Research finds that oligopeptide compares single amino acids
Absorption more effective, and can directly participate in the synthesis of protein, therefore improve the body utilization rate to protein.At aminoacid
In the case of obstacle occurs in transportation system, take in oligopeptide and but can obtain good assimilation effect.It addition, biological activity peptides tool
There is biological activity widely, such as immunomodulating, cholesterol reducing, blood pressure lowering, antithrombotic, anticancer, antiviral, antioxidation and clear
Except Free Radical, promote growth etc..The feature that biologically active peptide is efficient with it, safe at present is a dark horse, and gradually demonstrates
Its important function in clinical nutrition and be widely applied prospect.
Radix Ginseng is rare Chinese medicine, about the medicinal history having had more than 4,000 year of Radix Ginseng.Radix Ginseng the most in the world mainly has
Four kinds: i.e. " the west of " Jilin Radix Ginseng " of China, " Korean Ginseng " of Korea, " Fructus Arctii " of Japan and Canada, the U.S.
Radix Panacis Quinquefolii ".The Radix Ginseng of China is the dry root and rhizome of Araliaceae Radix Ginseng, mainly originates in Jilin Province.On JIUYUE 4th, 2012,
Ministry of Health of China approval Radix Ginseng become new resource food, Radix Ginseng application by by single Chinese crude drug and health promoting product be extended to food,
The fields such as beverage, scope significantly expands, and this is that the Radix Ginseng industry development of China provides new opportunity.Radix Ginseng have strongly invigorating primordial QI,
Promoting the production of body fluid to quench thirst, the effect such as calm the nerves.In recent years, a large amount of pharmacological researches, clinical observation and epidemiological investigation all confirm Radix Ginseng
Have and improve microcirculation, improve tissue anti-anoxia ability, suppression platelet aggregation, antitumor, defying age, radioprotective, anti-tired
The multiple biological activity such as labor.The chemical composition of Radix Ginseng is extremely complex, and the research to ginsenoside is the most at present, and therein low
Poly-peptides is studied less as composition important in Radix Ginseng relatively, has no about its application in resisting fatigue food or health food
Report.Radix Ginseng oligopeptide is not required to digestion at human body and can directly absorb, thus can avoid the waste of active substance, is greatly improved its medicine
Effect, can be as a kind of novel food with antifatigue effect or the formula of health product.
Summary of the invention
It is an object of the invention to provide a kind of low viscosity, easily absorb and absorb fast Jilin Radix Ginseng oligopeptide preparation resisting fatigue food
Purposes in product or health food, provides a kind of new way for carrying out fatigue alleviating by diet.
Wherein said food is powder, liquid beverage, milk powder and milk product or baking goods.
Wherein said health food is powder, tablet, soft/hard capsule or oral liquid.
Present invention finds existing material-Jilin Radix Ginseng oligopeptide and there is the function of resisting fatigue, it was found that it is in preparation resisting fatigue
Purposes in food or health food.Zoopery finds that supplementing Jilin Radix Ginseng oligopeptide can delay the generation of experiment mice fatigue
With the elimination accelerated fatigue, there is significant anti-fatigue effect.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention will be further described, and these examples should be understood to be merely illustrative of, rather than
Limit the scope of the present invention by any way.
Embodiment 1, research to experiment mice antifatigue effect
One, material and method
Sample: Jilin Radix Ginseng oligopeptide, is produced by Jilin Tai Gu biological engineering Co., Ltd, faint yellow solid powder, main
Wanting composition is the little molecule oligopeptide that molecular weight is less than 1000, and content is 93.45%, and free amino acid accounts for 3.94%.
Laboratory animal: healthy cleaning grade ICR male mice 336,6～8 week old, body weight 18～22g, is cured by Peking University
Department of the Chinese Academy of Sciences's Experimental Animal Center provides.Laboratory animal sub-cage rearing, 6, every cage, free diet, drinking-water.Animals fed experimental room
Meeting GB cleaning grade, temperature range 25 DEG C ± 1 DEG C, relative humidity 50%～60%, room lighting controls in 12h/12h brightness
Circadian rhythm.
Two, experimental technique
Dosage and packet: male ICR mouse 336, claim Mouse Weight, be randomly divided into 7 groups by body weight, often organize 48 before experiment
Only.Set up blank group, lactalbumin group (0.50g/kg bw) and 5 Jilin Radix Ginseng oligopeptide dosage group (0.125g/kg bw
0.25g/kg bw, 0.50g/kg bw, 1.00g/kg bw, 2.00g/kg bw, respectively with Jilin Radix Ginseng oligopeptide one, two, three,
Four, five groups represent), each treated animal is further divided into 4 subgroups, often group 12.Blank group mouse stomach distilled water, its
The lactalbumin of remaining each group gavage respective concentration and the aqueous solution of Jilin Radix Ginseng oligopeptide.Each group mice all gives normal diet, from
By taking food and drinking water.Every day, gavage 1 time, carried out every experiment after continuous gavage 30d.
1) swimming with a load attached to the body experiment
Take 12 mices of each group of the 1st subgroup, after last gives given the test agent 30min, at the lead of rat-tail root load 5% body weight
Skin, is then placed in swimming trunk went swimming (depth of water >=30cm, water temperature 25 DEG C ± 1.0 DEG C) by mice, and mice starts record from swimming
The time of death is exhausted, as the mice burden swimming time to power.
2) serum urea nitrogen and the mensuration of Ldh Activity
Take 12 mices of each group of the 2nd subgroup, after last gives tested material 30min, after last is to given the test agent 30min, in temperature
Degree is not swimming with a load attached to the body 90min in the water of 30 DEG C, pulls out eyeball blood sampling after rest 60min.Put 4 DEG C of refrigerator about 3h, 2000r/min
Centrifugal 15min separates serum, with Japanese Olympus Co., Ltd. full automatic biochemical apparatus AU400 measure serum urea nitrogen content and
Ldh Activity, reagent all uses Yingke Xinchuang's reagent.
3) hepatic glycogen measures
Taking 12 mices of each group of the 3rd subgroup, last puts to death animal after giving tested material 30min, takes fresh liver sample physiology
After saline rinse, filter paper blots, and accurately weighs liver, by specimen weight (mg): alkali liquor volume (μ g)=1: 3, adds examination together
Guan Zhong, boiling water bath 20min, measure test kit description by hepatic glycogen after flowing water cooling and carry out, and test kit builds up life purchased from Nanjing
Thing Graduate School of Engineering.
4) blood lactase acid measures
Taking 12 mices of each group of the 4th subgroup, last adopts tail blood 20 μ l after giving tested material 30min, then mice does not bear a heavy burden in temperature
Degree is the water went swimming 10min of 30 DEG C, and after swimming, 0min and 20min takes a blood sample 20 μ l the most respectively, the blood adopted 3 times
It is the most transparent that sample is separately added in 0.48ml 1%NaF solution fully mixing, is subsequently adding 1.5ml protein precipitant, and vibration mixes,
3000r/min is centrifuged 10min, takes supernatant and measures lactic acid content.Blood lactase acid area under curve=1/2 × (the front blood lactase acid value of swimming+
The blood lactase acid value of 0min after swimming) × 10+1/2 × (blood lactase acid of rest 20min after the blood lactase acid value+swimming of 0min after swimming
Value) × 20
Statistical method: all experimental datas all withRepresent.SPSS13.0 software is used to carry out one factor analysis of variance, p ＜ 0.05
Statistically significant.
Three, experimental result
1) the Jilin Radix Ginseng oligopeptide impact on the mice burden swimming time
As shown in table 1, blank group and lactalbumin group mice burden swimming time there was no significant difference (p ＞ 0.05)；With
Lactalbumin group is compared, and all there are a certain degree of prolongation, Qi Zhongji Jilin Radix Ginseng oligopeptide each dosage group mice burden swimming time
Woods Radix Ginseng oligopeptide two groups is the most notable (p ＜ 0.01).
2) Jilin Radix Ginseng oligopeptide is on mice serum blood urea nitrogen and the impact of lactic acid dehydrogenase activity
As shown in table 2, that there are no significant is poor for blank group and lactalbumin group mice serum blood urea nitrogen and lactic acid dehydrogenase activity
Different (p ＞ 0.05)；And compared with lactalbumin group, Jilin Radix Ginseng oligopeptide each dosage group serum urea nitrogen content all decreases,
Lactic acid dehydrogenase activity has strengthened, and wherein the difference of Jilin Radix Ginseng oligopeptide one group and Jilin Radix Ginseng oligopeptide two groups has statistics
Learn meaning (p ＜ 0.05 or p ＜ 0.01).
Table 1 Jilin Radix Ginseng oligopeptide on the impact of mice swimming time (N=12)
Note: * represents p ＜ 0.05 compared with lactalbumin group.
Table 2 Jilin Radix Ginseng oligopeptide on the impact of mice serum blood urea nitrogen and lactic acid dehydrogenase activity (N=12)
Note: * represents p ＜ 0.05 compared with lactalbumin group；* represents p ＜ 0.01 compared with lactalbumin group.
3) the Jilin Radix Ginseng oligopeptide impact on Mouse Liver glycogen content
Blank group and lactalbumin group Mouse Liver glycogen content no significant difference (p ＞ 0.05)；Jilin Radix Ginseng is oligomeric
Two groups and three groups Mouse Liver glycogen levels of peptide are significantly higher than lactalbumin group (p ＜ 0.01 and p ＜ 0.05), are shown in Table 3.
Table 3 Jilin Radix Ginseng oligopeptide on the impact of Mouse Liver glycogen content (N=12)
Note: * represents p ＜ 0.05 compared with lactalbumin group；* represents p ＜ 0.01 compared with lactalbumin group.
4) the Jilin Radix Ginseng oligopeptide impact on Mouse Blood lactic acid content
The equal no difference of science of statistics of Serum lactic acid content (p ＞ 0.05) of blank group and lactalbumin group mice each time period；Jilin
20min after 0min and one, two, three groups of mices of Jilin Radix Ginseng oligopeptide are swum after two groups and the three groups mice swimming of Radix Ginseng oligopeptide
Blood lactase acid level is substantially less than lactalbumin group (p ＜ 0.05 or p ＜ 0.01)；Jilin Radix Ginseng oligopeptide in addition to the 5th group of mice remaining
3 time point blood lactase acid area under curve of four groups of mices are respectively less than lactalbumin group, and difference statistically significant (p ＜ 0.05 or
P ＜ 0.01), it is shown in Table 4.
Table 4 Jilin Radix Ginseng oligopeptide on the impact of Mouse Blood lactic acid (N=12)
Note: * represents p ＜ 0.05 compared with lactalbumin group；* represents p ＜ 0.01 compared with lactalbumin group.
Four, experiment conclusion
This research is by setting up blank group and lactalbumin group as a control group, and the resisting fatigue inquiring into Jilin Radix Ginseng oligopeptide is made
With.Result shows, Jilin Radix Ginseng oligopeptide with the generation of delay fatigue and the elimination accelerated fatigue, thus can play resisting fatigue
Effect, possesses the potentiality as a kind of Novel anti-fatigue preparation, and its appropriate concentration range is bw every day 0.125～1g/kg.
Claims (3)
1. Jilin Radix Ginseng oligopeptide purposes in the food or health food of preparation resisting fatigue.
The Jilin Radix Ginseng oligopeptide the most according to claim 1 purposes in the food or health food of preparation resisting fatigue, it is special
Levy and be: the food of described resisting fatigue is powder, liquid beverage, milk powder and milk product and baking goods.
The Jilin Radix Ginseng oligopeptide the most according to claim 1 purposes in the food or health food of preparation resisting fatigue, it is special
Levy and be: the health food of described improvement and sexual function improving is powder, tablet, soft/hard capsule and oral liquid.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510105325.0A CN106135906A (en) | 2015-03-11 | 2015-03-11 | Jilin Radix Ginseng oligopeptide purposes in the food or health food of preparation resisting fatigue |
| PCT/CN2016/070591 WO2016141775A1 (en) | 2015-03-11 | 2016-01-11 | Uses of jilin ginseng oligopeptide in preparing food product or healthcare food product for combating fatigue |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510105325.0A CN106135906A (en) | 2015-03-11 | 2015-03-11 | Jilin Radix Ginseng oligopeptide purposes in the food or health food of preparation resisting fatigue |
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| WO (1) | WO2016141775A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110338430A (en) * | 2019-07-04 | 2019-10-18 | 山东薇薇朵生物科技有限公司 | Ginseng oligopeptide is preparing the purposes in antifatigue food or health food |
| CN113598363A (en) * | 2021-08-12 | 2021-11-05 | 海南天壮营养工程有限公司 | Special medical-purpose total-nutrient formula food for cancer-related fatigue |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113812554A (en) * | 2020-06-13 | 2021-12-21 | 刘伟杰 | A beverage containing Ginseng radix and its preparation method |
| CN114041605A (en) * | 2021-11-17 | 2022-02-15 | 浙江诺衍生物科技有限公司 | Composition for regulating male hormone and sexual function and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103005435A (en) * | 2012-12-13 | 2013-04-03 | 北京康比特体育科技股份有限公司 | Anti-fatigue composition capable of improving speed endurance and preparation containing anti-fatigue composition |
| CN103704830A (en) * | 2013-11-26 | 2014-04-09 | 天基神元生物科技（大连）有限公司 | Method for preparing low-molecule ginsenoside peptide by bacillus natto fermentation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020087298A (en) * | 2001-05-15 | 2002-11-22 | 김원규 | Tonic composition comprising wild ginseng as main ingredient |
| JP5271534B2 (en) * | 2006-12-25 | 2013-08-21 | ライオン株式会社 | Muscle atrophy inhibitor |
| CN102652829A (en) * | 2012-04-25 | 2012-09-05 | 宗树伟 | Extraction method of ginseng peptide |
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- 2015-03-11 CN CN201510105325.0A patent/CN106135906A/en active Pending
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- 2016-01-11 WO PCT/CN2016/070591 patent/WO2016141775A1/en active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103005435A (en) * | 2012-12-13 | 2013-04-03 | 北京康比特体育科技股份有限公司 | Anti-fatigue composition capable of improving speed endurance and preparation containing anti-fatigue composition |
| CN103704830A (en) * | 2013-11-26 | 2014-04-09 | 天基神元生物科技（大连）有限公司 | Method for preparing low-molecule ginsenoside peptide by bacillus natto fermentation |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110338430A (en) * | 2019-07-04 | 2019-10-18 | 山东薇薇朵生物科技有限公司 | Ginseng oligopeptide is preparing the purposes in antifatigue food or health food |
| CN113598363A (en) * | 2021-08-12 | 2021-11-05 | 海南天壮营养工程有限公司 | Special medical-purpose total-nutrient formula food for cancer-related fatigue |
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| WO2016141775A1 (en) | 2016-09-15 |
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Application publication date: 20161123 |