CN106132401B - 用于增强酸性有益剂的局部施用的组合物及方法 - Google Patents
用于增强酸性有益剂的局部施用的组合物及方法 Download PDFInfo
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- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/65—Characterized by the composition of the particulate/core
- A61K2800/652—The particulate/core comprising organic material
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Abstract
Description
治疗持续时间 | 未治疗 | 基准(5%溶液) | 5%粉末-霜膏(实施例1) |
第1天 | 休止期 | 休止期 | 休止期 |
第2天 | 休止期 | 休止期 | 生长期 |
第3天 | 休止期 | 休止期 | 生长期 |
第6天 | 休止期 | 生长期 | 生长期 |
第2周 | 休止期 | 生长期 | 生长期 |
第3周 | 休止期 | 生长期 | 生长期 |
第4周 | 休止期 | 生长期 | 生长期 |
第5周 | 休止期 | 生长期 | 生长期 |
第6周 | 休止期 | 生长期 | 生长期 |
化学名 | 配方A | 配方B |
布洛芬 | 5 | 5 |
甘油 | 72 | 76 |
二甲基异山梨醇(DMI) | 5 | 0 |
四羟基丙基乙二胺(NEUTROL TE) | 10 | 11 |
热解法疏水性二氧化硅(AEROSIL R812S) | 8 | 8 |
总计: | 100 | 100 |
化学名 | 配方C | 配方D |
布洛芬 | 5 | 5 |
甘油 | 90 | 83 |
氢氧化钠(50重量%水溶液) | 2 | 2 |
水 | 3 | 10 |
热解法疏水性二氧化硅(AEROSIL R812S) | 7.5 | 7.5 |
总计: | 107.5 | 107.5 |
Claims (11)
Applications Claiming Priority (3)
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US14/230,535 US9468606B2 (en) | 2014-03-31 | 2014-03-31 | Compostions and methods for enhancing the topical application of an acidic benefit agent |
US14/230,535 | 2014-03-31 | ||
PCT/US2015/019588 WO2015153073A1 (en) | 2014-03-31 | 2015-03-10 | Compositions and methods for enhancing the topical application of an acidic benefit agent |
Publications (2)
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CN106132401A CN106132401A (zh) | 2016-11-16 |
CN106132401B true CN106132401B (zh) | 2020-06-09 |
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CN201580017197.2A Active CN106132401B (zh) | 2014-03-31 | 2015-03-10 | 用于增强酸性有益剂的局部施用的组合物及方法 |
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US (1) | US9468606B2 (zh) |
EP (1) | EP3125858B1 (zh) |
CN (1) | CN106132401B (zh) |
BR (1) | BR112016022159B8 (zh) |
CA (1) | CA2943179C (zh) |
ES (1) | ES2760262T3 (zh) |
RU (1) | RU2683779C2 (zh) |
WO (1) | WO2015153073A1 (zh) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9475709B2 (en) | 2010-08-25 | 2016-10-25 | Lockheed Martin Corporation | Perforated graphene deionization or desalination |
US9834809B2 (en) | 2014-02-28 | 2017-12-05 | Lockheed Martin Corporation | Syringe for obtaining nano-sized materials for selective assays and related methods of use |
US9744617B2 (en) | 2014-01-31 | 2017-08-29 | Lockheed Martin Corporation | Methods for perforating multi-layer graphene through ion bombardment |
US9610546B2 (en) | 2014-03-12 | 2017-04-04 | Lockheed Martin Corporation | Separation membranes formed from perforated graphene and methods for use thereof |
US10653824B2 (en) | 2012-05-25 | 2020-05-19 | Lockheed Martin Corporation | Two-dimensional materials and uses thereof |
US10980919B2 (en) | 2016-04-14 | 2021-04-20 | Lockheed Martin Corporation | Methods for in vivo and in vitro use of graphene and other two-dimensional materials |
US10005038B2 (en) | 2014-09-02 | 2018-06-26 | Lockheed Martin Corporation | Hemodialysis and hemofiltration membranes based upon a two-dimensional membrane material and methods employing same |
US10376845B2 (en) | 2016-04-14 | 2019-08-13 | Lockheed Martin Corporation | Membranes with tunable selectivity |
TW201504140A (zh) | 2013-03-12 | 2015-02-01 | Lockheed Corp | 形成具有均勻孔尺寸之多孔石墨烯之方法 |
US9572918B2 (en) | 2013-06-21 | 2017-02-21 | Lockheed Martin Corporation | Graphene-based filter for isolating a substance from blood |
EP3099645A4 (en) | 2014-01-31 | 2017-09-27 | Lockheed Martin Corporation | Processes for forming composite structures with a two-dimensional material using a porous, non-sacrificial supporting layer |
CA2938273A1 (en) | 2014-01-31 | 2015-08-06 | Peter V. Bedworth | Perforating two-dimensional materials using broad ion field |
JP2017512129A (ja) | 2014-03-12 | 2017-05-18 | ロッキード・マーチン・コーポレーション | 有孔グラフェンから形成された分離膜 |
WO2017023376A1 (en) | 2015-08-05 | 2017-02-09 | Lockheed Martin Corporation | Perforatable sheets of graphene-based material |
AU2016303049A1 (en) | 2015-08-06 | 2018-03-01 | Lockheed Martin Corporation | Nanoparticle modification and perforation of graphene |
WO2017180137A1 (en) | 2016-04-14 | 2017-10-19 | Lockheed Martin Corporation | Method for treating graphene sheets for large-scale transfer using free-float method |
JP2019519756A (ja) | 2016-04-14 | 2019-07-11 | ロッキード・マーチン・コーポレーション | 欠陥形成または欠陥修復をその場で監視して制御する方法 |
CA3020874A1 (en) | 2016-04-14 | 2017-10-19 | Lockheed Martin Corporation | Two-dimensional membrane structures having flow passages |
CA3020880A1 (en) | 2016-04-14 | 2017-10-19 | Lockheed Martin Corporation | Selective interfacial mitigation of graphene defects |
RU2019119089A (ru) | 2016-11-28 | 2020-12-21 | Целликс Био Прайвет Лимитед | Композиции и способы лечения грибковых инфекций |
WO2018118635A1 (en) * | 2016-12-23 | 2018-06-28 | Avon Products, Inc. | Stabilized topical compositions |
CN106727682A (zh) * | 2017-01-20 | 2017-05-31 | 李玉红 | 一种用于治疗脱发的制剂 |
JP2023509784A (ja) * | 2020-01-10 | 2023-03-09 | トピックス ファーマシューティカルズ,インコーポレイテッド | 活性薬剤の経皮送達のための皮膚処置方法および組成物 |
FR3115200B1 (fr) * | 2020-10-21 | 2023-11-03 | Oreal | Composition cosmetique contenant des capsules de type cœur/enveloppe |
RU2765838C1 (ru) * | 2021-02-16 | 2022-02-03 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Донской государственный аграрный университет" | Средство для лечения послеродового мастита и эндометрита у коров |
WO2023250369A2 (en) * | 2022-06-21 | 2023-12-28 | Taro Pharmaceutical Industries Ltd. | Topical naftifine compositions |
US11951082B2 (en) | 2022-08-22 | 2024-04-09 | Ford Therapeutics, Llc | Composition of chlorhexidine |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011076518A1 (en) * | 2009-12-26 | 2011-06-30 | Evonik Degussa Gmbh | Water containing powder composition |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1467023A1 (de) | 1964-02-28 | 1969-01-23 | Degussa | Verfahren zur Inkorporierung von Wasser in feinst verteilter Kieselsaeure |
DE2844052A1 (de) | 1978-10-10 | 1980-04-30 | Degussa | Waessrige dispersion einer hydrophoben kieselsaeure |
IL105553A (en) * | 1992-05-06 | 1998-01-04 | Janssen Pharmaceutica Inc | Solid dosage forms consisting of a porous network of matrix that releases a substance that dissipates rapidly in water |
US5229076A (en) * | 1992-05-08 | 1993-07-20 | Fagher Richard H | Method for reducing polymer build-up in a polymerization reactor |
US6174533B1 (en) | 1997-05-23 | 2001-01-16 | The Procter & Gamble Company | Skin care compositions and method of improving skin appearance |
AUPP310798A0 (en) | 1998-04-22 | 1998-05-14 | Soltec Research Pty Ltd | Vehicle system for a composition comprising a piperidinopyrimidine derivative |
EP0964054A1 (en) | 1998-06-11 | 1999-12-15 | Tiense Suikerraffinaderij N.V. (Raffinerie Tirlemontoise S.A.) | Surface-active alkylurethanes of fructans |
US6284234B1 (en) | 1998-08-04 | 2001-09-04 | Johnson & Johnson Consumer Companies, Inc. | Topical delivery systems for active agents |
US20020006418A1 (en) | 1998-10-13 | 2002-01-17 | John Kung | Composition to enhance permeation of topical skin agents |
JP2000309505A (ja) | 1999-02-26 | 2000-11-07 | Shiseido Co Ltd | 粉末化粧料 |
US6290941B1 (en) | 1999-11-23 | 2001-09-18 | Color Access, Inc. | Powder to liquid compositions |
EP1269972B1 (en) | 2000-04-07 | 2005-10-19 | Taisho Pharmaceutical Co., Ltd | Hair growth stimulant compositions with sustained action |
US6413548B1 (en) | 2000-05-10 | 2002-07-02 | Aveka, Inc. | Particulate encapsulation of liquid beads |
CN100398085C (zh) | 2001-01-18 | 2008-07-02 | 株式会社资生堂 | 干式水的制备方法 |
US7914811B2 (en) * | 2001-06-29 | 2011-03-29 | Mcneil-Ppc, Inc. | Brittle-coating, soft core dosage form |
US20050220860A1 (en) | 2002-04-15 | 2005-10-06 | Kim Dong Y | Stabilized pure vitamin-C in powder to liquid form using multi-encapsulation method |
US7477939B2 (en) | 2003-06-30 | 2009-01-13 | Johnson & Johnson Consumer Companies, Inc. | Methods of treating a wound with galvanic generated electricity |
US8734421B2 (en) | 2003-06-30 | 2014-05-27 | Johnson & Johnson Consumer Companies, Inc. | Methods of treating pores on the skin with electricity |
US7476222B2 (en) | 2003-06-30 | 2009-01-13 | Johnson & Johnson Consumer Companies, Inc. | Methods of reducing the appearance of pigmentation with galvanic generated electricity |
US7477940B2 (en) | 2003-06-30 | 2009-01-13 | J&J Consumer Companies, Inc. | Methods of administering an active agent to a human barrier membrane with galvanic generated electricity |
US20050084510A1 (en) | 2003-10-20 | 2005-04-21 | Carson John C. | Water in oil formulations, method to prepare same, and personal care products formed using same |
WO2005058256A1 (de) | 2003-12-01 | 2005-06-30 | Degussa Ag | Verstreichbare kosmetische zubereitung mit hohem wassergehalt |
US20050163811A1 (en) | 2004-01-23 | 2005-07-28 | Richard Lee | Topical solutions comprising high concentrations of piperidinopyrimidine derivatives and methods of use thereof |
US20080138390A1 (en) * | 2004-04-07 | 2008-06-12 | Tsung-Min Hsu | Transdermal Delivery System For Use With Basic Permeation Enhancers |
US20060008485A1 (en) | 2004-07-12 | 2006-01-12 | Ferone James J | Packaged cosmetic compositions and related methods |
DE102004056862A1 (de) | 2004-11-25 | 2006-06-14 | Degussa Ag | Pulverförmige, kosmetische Zubereitung mit hohem Wassergehalt |
DE102005055226A1 (de) | 2004-12-24 | 2006-07-13 | Degussa Ag | Lagerung pulverförmiger Stoffe mit hohem Wassergehalt |
US20070154426A1 (en) | 2006-01-05 | 2007-07-05 | Hansen Angela M | Powdered water cosmetic compositions and related methods |
US7417020B2 (en) | 2006-05-05 | 2008-08-26 | Johnson & Johnson Consumer Companies, Inc. | Compositions comprising low-DP polymerized surfactants and methods of use thereof |
US20080038557A1 (en) | 2006-08-08 | 2008-02-14 | The Procter & Gamble Company | Process for making collapsible water-containing capsules |
US7704533B2 (en) | 2006-12-13 | 2010-04-27 | J&J Consumer Companies, Inc. | Compositions and methods of inducing hair growth utilizing Continus coggygria |
TWI411448B (zh) | 2007-12-27 | 2013-10-11 | Avon Prod Inc | 適合用於化妝品之光學模糊色素組合物 |
JP5519706B2 (ja) | 2009-02-06 | 2014-06-11 | ザ プロクター アンド ギャンブル カンパニー | 崩壊性水含有カプセル |
US20100268335A1 (en) | 2009-03-27 | 2010-10-21 | Chunlin Yang | Medical devices with galvanic particulates |
US8399590B2 (en) | 2009-10-07 | 2013-03-19 | Akzo Nobel Chemicals International B.V. | Superhydrophilic amphiphilic copolymers and processes for making the same |
US8258250B2 (en) | 2009-10-07 | 2012-09-04 | Johnson & Johnson Consumer Companies, Inc. | Compositions comprising superhydrophilic amphiphilic copolymers and methods of use thereof |
US8545821B2 (en) | 2009-11-05 | 2013-10-01 | Avon Products, Inc. | Cosmetic use of water-redispersible powders |
US9793199B2 (en) | 2009-12-18 | 2017-10-17 | Ati Technologies Ulc | Circuit board with via trace connection and method of making the same |
KR20110091461A (ko) | 2010-02-05 | 2011-08-11 | 존슨 앤드 존슨 컨수머 캄파니즈, 인코포레이티드 | 갈바니 미립자를 포함하는 립 조성물 |
WO2012012509A1 (en) | 2010-07-23 | 2012-01-26 | Johnson & Johnson Consumer Companies, Inc. | Corrosion current-generating metal particulates and use thereof |
DE102011077298A1 (de) | 2011-06-09 | 2012-12-13 | Evonik Degussa Gmbh | Kern-Hülle-Partikel mit einem hohen Gehalt an Glycerin, ihre Herstellung und Verwendung |
DE102011088840A1 (de) | 2011-12-16 | 2013-06-20 | Henkel Ag & Co. Kgaa | Pulverförmige Haarkosmetika |
WO2014099946A1 (en) | 2012-12-19 | 2014-06-26 | Johnson & Johnson Consumer Companies, Inc. | Anhydrous powder-to-liquid particles |
-
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- 2014-03-31 US US14/230,535 patent/US9468606B2/en active Active
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- 2015-03-10 RU RU2016142398A patent/RU2683779C2/ru active
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011076518A1 (en) * | 2009-12-26 | 2011-06-30 | Evonik Degussa Gmbh | Water containing powder composition |
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EP3125858B1 (en) | 2019-09-25 |
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CN106132401A (zh) | 2016-11-16 |
EP3125858A1 (en) | 2017-02-08 |
CA2943179A1 (en) | 2015-10-08 |
RU2016142398A (ru) | 2018-05-03 |
CA2943179C (en) | 2022-05-31 |
US9468606B2 (en) | 2016-10-18 |
WO2015153073A1 (en) | 2015-10-08 |
BR112016022159B1 (pt) | 2020-11-17 |
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