CN106075605A - 一种心脑血管支架的制备方法 - Google Patents

一种心脑血管支架的制备方法 Download PDF

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CN106075605A
CN106075605A CN201610567892.2A CN201610567892A CN106075605A CN 106075605 A CN106075605 A CN 106075605A CN 201610567892 A CN201610567892 A CN 201610567892A CN 106075605 A CN106075605 A CN 106075605A
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rest body
cardiovascular
prepared
preparation
vessel support
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马英祥
姜晓筑
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Chengdu Jiabaoxiang Biological Technology Co Ltd
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Chengdu Jiabaoxiang Biological Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/022—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

本发明公开了一种心脑血管支架的制备方法，包括以下步骤：(1)配备原料：该心脑血管支架中的合金成分的重量百分比为锆2％～3％，钼1％～3％，铌4％～5％，其余为镁和钛，其中镁和钛的重量比为2∶1；（2）制备支架基体：注射成形机的模具中直接注射形成，制备得所述支架基体；（3）聚合物溶液的制备：将无水乙醇和氢氟酸混合，搅拌至均匀，再加入钛酸四丁酯混匀得溶液，其中氢氟酸浓度为0.2～0.3mol/L，钛酸四丁酯浓度为0.15～0.25mol/L；（4）将支架基体放入步骤(3)制备的聚合物溶液中，水热反应12～15h，取出支架基体，用去离子水冲洗干净，干燥，在支架基体表面形成涂层。

Description

一种心脑血管支架的制备方法
技术领域
本发明涉及血管支架技术领域，具体而言，涉及一种心脑血管支架的制备方法。
背景技术
血管类疾病严重危害人类身体健康，全球每年都有数以万计的人由于血管老化、损伤、病变等多方面原因患有血管类疾病。
目前，心脑血管常见的疾病主要有动脉狭窄、动脉瘤等，这些疾病若不及时治疗可能会导致血管堵塞、瘤体破裂，将严重危害人类的生命安全。目前支架介入术是治疗心血管疾病的主要手段之一，介入材料与人体组织相互作用研究，越来越引起人们的关注，所谓的人体组织是指血管、骨质、器官和体液等。临床上广泛使用的血管支架主要有金属裸支架和药物洗脱支架。
发明内容
本发明的目的在于提供一种心脑血管支架的制备方法，以解决现有技术中的不足。
为实现本发明目的，采用的技术方案为：
一种心脑血管支架的制备方法，其特征在于，包括以下步骤：
(1) 配备原料：该心脑血管支架中的合金成分的重量百分比为锆2％～3％，钼1％～3％，铌4％～5％，其余为镁和钛，其中镁和钛的重量比为2∶1；
（2） 制备支架基体：注射成形机的模具中直接注射形成，制备得所述支架基体；
（3） 聚合物溶液的制备：将无水乙醇和氢氟酸混合，搅拌至均匀，再加入钛酸四丁酯混匀得溶液，其中氢氟酸浓度为0.2～0.3mol/L，钛酸四丁酯浓度为0.15～0.25mol/L；向该溶液中加入其1/100～1/50体积的去离子水溶液，该去离子水溶液中溶有氟化盐，其浓度为0.2～0.3mol/L；
（4） 将支架基体放入步骤(3)制备的聚合物溶液中，水热反应12～15h，取出支架基体，用去离子水冲洗干净，干燥，在支架基体表面形成涂层。
本发明的有益效果是，
本发明大幅度提高了血管支架的抗腐蚀性能、屈服强度和塑性，而且满足了临床对血管支架消溶速度及时间要求，消除了血管硬化的问题，同时还具有较高的安全性和可靠性。
具体实施方式
下面通过具体的实施例子对本发明做进一步的详细描述。
一种心脑血管支架的制备方法，其特征在于，包括以下步骤：
(1) 配备原料：该心脑血管支架中的合金成分的重量百分比为锆2％～3％，钼1％～3％，铌4％～5％，其余为镁和钛，其中镁和钛的重量比为2∶1；
（2） 制备支架基体：注射成形机的模具中直接注射形成，制备得所述支架基体；
（3） 聚合物溶液的制备：将无水乙醇和氢氟酸混合，搅拌至均匀，再加入钛酸四丁酯混匀得溶液，其中氢氟酸浓度为0.2～0.3mol/L，钛酸四丁酯浓度为0.15～0.25mol/L；向该溶液中加入其1/100～1/50体积的去离子水溶液，该去离子水溶液中溶有氟化盐，其浓度为0.2～0.3mol/L；
（4） 将支架基体放入步骤(3)制备的聚合物溶液中，水热反应12～15h，取出支架基体，用去离子水冲洗干净，干燥，在支架基体表面形成涂层。
本发明大幅度提高了血管支架的抗腐蚀性能、屈服强度和塑性，而且满足了临床对血管支架消溶速度及时间要求，消除了血管硬化的问题，同时还具有较高的安全性和可靠性。
以上所述仅为本发明的优选实施例而已，并不用于限制本发明，对于本领域的技术人员来说，本发明可以有各种更改和变化。凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。

Claims (1)

1.一种心脑血管支架的制备方法，其特征在于，包括以下步骤：
(1) 配备原料：该心脑血管支架中的合金成分的重量百分比为锆2％～3％，钼1％～3％，铌4％～5％，其余为镁和钛，其中镁和钛的重量比为2∶1；
（2） 制备支架基体：注射成形机的模具中直接注射形成，制备得所述支架基体；
（3） 聚合物溶液的制备：将无水乙醇和氢氟酸混合，搅拌至均匀，再加入钛酸四丁酯混匀得溶液，其中氢氟酸浓度为0.2～0.3mol/L，钛酸四丁酯浓度为0.15～0.25mol/L；向该溶液中加入其1/100～1/50体积的去离子水溶液，该去离子水溶液中溶有氟化盐，其浓度为0.2～0.3mol/L；
（4） 将支架基体放入步骤(3)制备的聚合物溶液中，水热反应12～15h，取出支架基体，用去离子水冲洗干净，干燥，在支架基体表面形成涂层。
CN201610567892.2A 2016-07-19 2016-07-19 一种心脑血管支架的制备方法 Pending CN106075605A (zh)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101005812A (zh) * 2003-05-07 2007-07-25 先进生物假体表面有限公司 可植入性金属移植物及其制造方法
CN103334105A (zh) * 2013-07-22 2013-10-02 郑州大学 一种镁合金血管支架表面纳米氧化钛涂层的水热制备方法
CN105381508A (zh) * 2015-12-28 2016-03-09 青岛博泰美联化工技术有限公司 一种血管内支架及制备方法
CN105664264A (zh) * 2016-04-11 2016-06-15 刘国远 一种心脑血管支架的制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101005812A (zh) * 2003-05-07 2007-07-25 先进生物假体表面有限公司 可植入性金属移植物及其制造方法
CN103334105A (zh) * 2013-07-22 2013-10-02 郑州大学 一种镁合金血管支架表面纳米氧化钛涂层的水热制备方法
CN105381508A (zh) * 2015-12-28 2016-03-09 青岛博泰美联化工技术有限公司 一种血管内支架及制备方法
CN105664264A (zh) * 2016-04-11 2016-06-15 刘国远 一种心脑血管支架的制备方法

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