CN106008618A - 一种红景天苷的制备方法 - Google Patents
一种红景天苷的制备方法 Download PDFInfo
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- CN106008618A CN106008618A CN201610462599.XA CN201610462599A CN106008618A CN 106008618 A CN106008618 A CN 106008618A CN 201610462599 A CN201610462599 A CN 201610462599A CN 106008618 A CN106008618 A CN 106008618A
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- rhodioside
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- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- ILRCGYURZSFMEG-UHFFFAOYSA-N Salidroside Natural products OC1C(O)C(O)C(CO)OC1OCCC1=CC=C(O)C=C1 ILRCGYURZSFMEG-UHFFFAOYSA-N 0.000 title abstract description 5
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- 239000000706 filtrate Substances 0.000 claims abstract description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000002244 precipitate Substances 0.000 claims abstract description 13
- 238000001556 precipitation Methods 0.000 claims abstract description 10
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 10
- 238000001291 vacuum drying Methods 0.000 claims abstract description 8
- 238000005406 washing Methods 0.000 claims abstract description 8
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 69
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 21
- 239000000463 material Substances 0.000 claims description 14
- 238000002137 ultrasound extraction Methods 0.000 claims description 10
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- 229930182470 glycoside Natural products 0.000 claims description 3
- 150000002338 glycosides Chemical class 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 9
- 238000000605 extraction Methods 0.000 abstract description 4
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- YCCILVSKPBXVIP-UHFFFAOYSA-N 2-(4-hydroxyphenyl)ethanol Chemical compound OCCC1=CC=C(O)C=C1 YCCILVSKPBXVIP-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
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- KZJWDPNRJALLNS-VPUBHVLGSA-N (-)-beta-Sitosterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@@H](C(C)C)CC)C)CC4)CC3)CC=2)CC1 KZJWDPNRJALLNS-VPUBHVLGSA-N 0.000 description 1
- CSVWWLUMXNHWSU-UHFFFAOYSA-N (22E)-(24xi)-24-ethyl-5alpha-cholest-22-en-3beta-ol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(CC)C(C)C)C1(C)CC2 CSVWWLUMXNHWSU-UHFFFAOYSA-N 0.000 description 1
- ZTOJFFHGPLIVKC-YAFCTCPESA-N (2e)-3-ethyl-2-[(z)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound S\1C2=CC(S(O)(=O)=O)=CC=C2N(CC)C/1=N/N=C1/SC2=CC(S(O)(=O)=O)=CC=C2N1CC ZTOJFFHGPLIVKC-YAFCTCPESA-N 0.000 description 1
- KLEXDBGYSOIREE-UHFFFAOYSA-N 24xi-n-propylcholesterol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CCC)C(C)C)C1(C)CC2 KLEXDBGYSOIREE-UHFFFAOYSA-N 0.000 description 1
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- LPZCCMIISIBREI-MTFRKTCUSA-N Citrostadienol Natural products CC=C(CC[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4[C@H](C)[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C LPZCCMIISIBREI-MTFRKTCUSA-N 0.000 description 1
- 241000220284 Crassulaceae Species 0.000 description 1
- ARVGMISWLZPBCH-UHFFFAOYSA-N Dehydro-beta-sitosterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)CCC(CC)C(C)C)CCC33)C)C3=CC=C21 ARVGMISWLZPBCH-UHFFFAOYSA-N 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- DBLDQZASZZMNSL-QMMMGPOBSA-N L-tyrosinol Natural products OC[C@@H](N)CC1=CC=C(O)C=C1 DBLDQZASZZMNSL-QMMMGPOBSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 241001529246 Platymiscium Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
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- 230000000259 anti-tumor effect Effects 0.000 description 1
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- MJVXAPPOFPTTCA-UHFFFAOYSA-N beta-Sistosterol Natural products CCC(CCC(C)C1CCC2C3CC=C4C(C)C(O)CCC4(C)C3CCC12C)C(C)C MJVXAPPOFPTTCA-UHFFFAOYSA-N 0.000 description 1
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 1
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000003305 oral gavage Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000004223 radioprotective effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
- 229950005143 sitosterol Drugs 0.000 description 1
- NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 description 1
- 235000015500 sitosterol Nutrition 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 235000004330 tyrosol Nutrition 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
- C07H1/08—Separation; Purification from natural products
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201610462599.XA CN106008618B (zh) | 2016-06-22 | 2016-06-22 | 一种红景天苷的制备方法 |
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CN201610462599.XA CN106008618B (zh) | 2016-06-22 | 2016-06-22 | 一种红景天苷的制备方法 |
Publications (2)
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CN106008618A true CN106008618A (zh) | 2016-10-12 |
CN106008618B CN106008618B (zh) | 2019-01-04 |
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CN201610462599.XA Active CN106008618B (zh) | 2016-06-22 | 2016-06-22 | 一种红景天苷的制备方法 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107602635A (zh) * | 2017-10-19 | 2018-01-19 | 阜康市天鼎生物科技有限公司 | 一种红景天中红景天苷的高效提取分离工艺 |
CN107857784A (zh) * | 2017-12-18 | 2018-03-30 | 四川合盛生物科技有限公司 | 一种从红景天中提取红景天苷的方法 |
CN108271984A (zh) * | 2018-01-02 | 2018-07-13 | 中国农业科学院农产品加工研究所 | 红景天固体饮料及其制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103923132A (zh) * | 2014-04-16 | 2014-07-16 | 安徽博格生物科技有限公司 | 天然红景天中红景天甙的超声提取工艺 |
-
2016
- 2016-06-22 CN CN201610462599.XA patent/CN106008618B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103923132A (zh) * | 2014-04-16 | 2014-07-16 | 安徽博格生物科技有限公司 | 天然红景天中红景天甙的超声提取工艺 |
Non-Patent Citations (6)
Title |
---|
张利娟 等: "高山红景天浸提液超滤过程中温度的影响", 《河南大学学报(自然科学版)》 * |
王丹: "红景天苷的提取与纯化", 《中国优秀硕士学位论文全文数据库(电子期刊)》 * |
程子毓 等: "高压提取红景天根中红景天苷工艺研究", 《安徽农业科学》 * |
郭娜 等: "红景天苷提取工艺研究进展", 《北方园艺》 * |
陈健: "红景天苷的超高压提取及其药理活性的初步研究", 《中国优秀硕士学位论文全文数据库(电子期刊)》 * |
雷富平 等: "红景天中红景天苷的提取及其应用前景", 《饮料工业》 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107602635A (zh) * | 2017-10-19 | 2018-01-19 | 阜康市天鼎生物科技有限公司 | 一种红景天中红景天苷的高效提取分离工艺 |
CN107857784A (zh) * | 2017-12-18 | 2018-03-30 | 四川合盛生物科技有限公司 | 一种从红景天中提取红景天苷的方法 |
CN108271984A (zh) * | 2018-01-02 | 2018-07-13 | 中国农业科学院农产品加工研究所 | 红景天固体饮料及其制备方法 |
CN108271984B (zh) * | 2018-01-02 | 2021-05-11 | 中国农业科学院农产品加工研究所 | 红景天固体饮料及其制备方法 |
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CN106008618B (zh) | 2019-01-04 |
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Effective date of registration: 20181115 Address after: 541004 pavement 1-4 and 2-4, 1 Tung ring new village, Putuo Road, East Ring Road, Qixing District, Guilin, the Guangxi Zhuang Autonomous Region Applicant after: GUILIN RONGTONG TECHNOLOGY CO., LTD. Address before: 541002 No. 1 Jing Ping Road, Xiangshan District, Guilin, the Guangxi Zhuang Autonomous Region. Applicant before: Gao Feng |
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Effective date of registration: 20211213 Address after: 264205 No. 68, Qilu Avenue, economic and Technological Development Zone, Weihai City, Shandong Province Patentee after: WEIHAI ZIGUANG BIOLOGICAL TECHNOLOGY DEVELOPMENT CO.,LTD. Address before: 541004 pavement 1-4 and 2-4, 1 Tung ring new village, Putuo Road, East Ring Road, Qixing District, Guilin, the Guangxi Zhuang Autonomous Region Patentee before: GUILIN RONGTONG TECHNOLOGY Co.,Ltd. |
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